Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 351
• Symbol: APP
• Description: amyloid beta precursor protein

DataSource: http://genomecrispr.dkfz.de/#!/results/APP

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
26089931	26089954	21	+	26472758	Jiyoye	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	-0.07056616240139024	[336]	[241]	0	hSpCas9	negative selection	8630
25911770	25911793	21	+	26472758	Jiyoye	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	-0.43445902282553717	[361]	[201]	-3	hSpCas9	negative selection	8631
25911740	25911763	21	-	26472758	Jiyoye	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	-0.7532892906873727	[37]	[16]	-5	hSpCas9	negative selection	8632
26053284	26053307	21	-	26472758	Jiyoye	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	-0.35791958584412953	[327]	[192]	-3	hSpCas9	negative selection	8633
26022014	26022037	21	-	26472758	Jiyoye	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	0.7592354477343903	[198]	[253]	5	hSpCas9	negative selection	8634
25975056	25975079	21	+	26472758	Jiyoye	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-1.3201400426266132	[148]	[44]	-7	hSpCas9	negative selection	8635
25954656	25954679	21	+	26472758	Jiyoye	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	-0.6252460961865043	[44]	[21]	-4	hSpCas9	negative selection	8636
25954614	25954637	21	-	26472758	Jiyoye	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	-1.7341804677396682	[74]	[16]	-8	hSpCas9	negative selection	8637
25911837	25911860	21	-	26472758	Jiyoye	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	4.655102894949458	[0]	[18]	9	hSpCas9	negative selection	8638
25911823	25911846	21	+	26472758	Jiyoye	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	0.928007544807314	[45]	[65]	6	hSpCas9	negative selection	8639
26089931	26089954	21	+	26472758	KBM7	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.2573970089742946	[857,890]	[431,550]	2	hSpCas9	negative selection	199748
25911770	25911793	21	+	26472758	KBM7	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	0.14558492184543426	[775,765]	[417,388]	1	hSpCas9	negative selection	199749
25911740	25911763	21	-	26472758	KBM7	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	0.7981076079041429	[6,50]	[31,19]	8	hSpCas9	negative selection	199750
26053284	26053307	21	-	26472758	KBM7	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	0.19737131462611313	[782,857]	[416,472]	2	hSpCas9	negative selection	199751
26022014	26022037	21	-	26472758	KBM7	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	-0.17484934514181538	[1260,763]	[503,331]	-2	hSpCas9	negative selection	199752
25975056	25975079	21	+	26472758	KBM7	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-0.500745347096692	[429,398]	[158,118]	-4	hSpCas9	negative selection	199753
25954656	25954679	21	+	26472758	KBM7	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	0.5767317969933254	[144,99]	[42,121]	6	hSpCas9	negative selection	199754
25954614	25954637	21	-	26472758	KBM7	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	0.2162773637856481	[157,159]	[99,75]	2	hSpCas9	negative selection	199755
25911837	25911860	21	-	26472758	KBM7	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	0.5000201310690384	[68,46]	[18,54]	5	hSpCas9	negative selection	199756
25911823	25911846	21	+	26472758	KBM7	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	0.25405017992661993	[206,199]	[67,155]	2	hSpCas9	negative selection	199757
26089931	26089954	21	+	26472758	Raji	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.659924558402378	[359]	[131]	6	hSpCas9	negative selection	390866
25911770	25911793	21	+	26472758	Raji	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	0.48877064521052627	[346]	[112]	4	hSpCas9	negative selection	390867
25911740	25911763	21	-	26472758	Raji	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	5.429311630260962	[0]	[9]	9	hSpCas9	negative selection	390868
26053284	26053307	21	-	26472758	Raji	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	0.7982415954420805	[336]	[135]	7	hSpCas9	negative selection	390869
26022014	26022037	21	-	26472758	Raji	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	0.7894685029928605	[358]	[143]	7	hSpCas9	negative selection	390870
25975056	25975079	21	+	26472758	Raji	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	0.18681800286800432	[105]	[27]	1	hSpCas9	negative selection	390871
25954656	25954679	21	+	26472758	Raji	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	0.22767776909131143	[91]	[24]	2	hSpCas9	negative selection	390872
25954614	25954637	21	-	26472758	Raji	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	0.7663466175385323	[37]	[14]	7	hSpCas9	negative selection	390873
25911837	25911860	21	-	26472758	Raji	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	1.2773085368159118	[15]	[8]	9	hSpCas9	negative selection	390874
25911823	25911846	21	+	26472758	Raji	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	-0.5479682932389546	[125]	[19]	-4	hSpCas9	negative selection	390875
26089931	26089954	21	+	26472758	K562	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.6074665206452183	[670]	[862]	5	hSpCas9	negative selection	581984
25911770	25911793	21	+	26472758	K562	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	0.6789422743796232	[477]	[645]	5	hSpCas9	negative selection	581985
25911740	25911763	21	-	26472758	K562	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	-0.5440771671398412	[18]	[10]	-3	hSpCas9	negative selection	581986
26053284	26053307	21	-	26472758	K562	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	-0.3599961357208816	[671]	[441]	-2	hSpCas9	negative selection	581987
26022014	26022037	21	-	26472758	K562	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	-0.11698080801032362	[879]	[684]	-1	hSpCas9	negative selection	581988
25975056	25975079	21	+	26472758	K562	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-1.0850169038898567	[288]	[114]	-5	hSpCas9	negative selection	581989
25954656	25954679	21	+	26472758	K562	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	0.8951832867833491	[99]	[156]	7	hSpCas9	negative selection	581990
25954614	25954637	21	-	26472758	K562	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	0.3803963971854216	[171]	[188]	3	hSpCas9	negative selection	581991
25911837	25911860	21	-	26472758	K562	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	-2.988242029123828	[46]	[4]	-8	hSpCas9	negative selection	581992
25911823	25911846	21	+	26472758	K562	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	-1.9067453456672037	[190]	[42]	-7	hSpCas9	negative selection	581993
25982420	25982443	21	-	26627737	DLD1	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.44327111231884503	[311]	[84,187,127]	4	hSpCas9	negative selection	815865
26000064	26000087	21	-	26627737	DLD1	viability	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	0.13762953408706635	[927]	[280,427,261]	1	hSpCas9	negative selection	815866
26051119	26051142	21	-	26627737	DLD1	viability	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	1.0915133813699456	[194]	[98,114,168]	8	hSpCas9	negative selection	815867
26053305	26053328	21	+	26627737	DLD1	viability	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.694760295098638	[397]	[197,243,168]	7	hSpCas9	negative selection	815868
26089996	26090019	21	-	26627737	DLD1	viability	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	0.45986273022627455	[858]	[389,527,219]	5	hSpCas9	negative selection	815869
25982420	25982443	21	-	26627737	GBM cells	viability after 5 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.37262728149213675	[264]	[163,203]	6	hSpCas9	negative selection	898180
26000064	26000087	21	-	26627737	GBM cells	viability after 5 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	0.6291925739246487	[172]	[126,159]	8	hSpCas9	negative selection	898181
26051119	26051142	21	-	26627737	GBM cells	viability after 5 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	1.9925729820999307	[40]	[99,74]	9	hSpCas9	negative selection	898182
26053305	26053328	21	+	26627737	GBM cells	viability after 5 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.4508475752193711	[323]	[203,270]	6	hSpCas9	negative selection	898183
26089996	26090019	21	-	26627737	GBM cells	viability after 5 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.01290059936211807	[586]	[307,315]	0	hSpCas9	negative selection	898184
25982420	25982443	21	-	26627737	GBM cells	viability after 13 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.5269197228244924	[264]	[274,151]	6	hSpCas9	negative selection	980495
26000064	26000087	21	-	26627737	GBM cells	viability after 13 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	0.4025264408316139	[172]	[133,115]	5	hSpCas9	negative selection	980496
26051119	26051142	21	-	26627737	GBM cells	viability after 13 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	1.7633773087117972	[40]	[85,66]	9	hSpCas9	negative selection	980497
26053305	26053328	21	+	26627737	GBM cells	viability after 13 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.7379871778704399	[323]	[274,307]	8	hSpCas9	negative selection	980498
26089996	26090019	21	-	26627737	GBM cells	viability after 13 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.19808168248873637	[586]	[302,256]	-2	hSpCas9	negative selection	980499
25982420	25982443	21	-	26627737	GBM cells	viability after 21 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.015920970336833304	[264]	[143,146]	0	hSpCas9	negative selection	1062810
26000064	26000087	21	-	26627737	GBM cells	viability after 21 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	0.9436786062091489	[172]	[185,175]	8	hSpCas9	negative selection	1062811
26051119	26051142	21	-	26627737	GBM cells	viability after 21 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	1.3366049675777112	[40]	[61,50]	9	hSpCas9	negative selection	1062812
26053305	26053328	21	+	26627737	GBM cells	viability after 21 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.8810246847374714	[323]	[366,284]	8	hSpCas9	negative selection	1062813
26089996	26090019	21	-	26627737	GBM cells	viability after 21 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	0.5363261619092807	[586]	[485,440]	5	hSpCas9	negative selection	1062814
25982420	25982443	21	-	26627737	RPE1	viability after 9 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.1919534577046821	[799]	[34,456]	-1	hSpCas9	negative selection	1145125
26000064	26000087	21	-	26627737	RPE1	viability after 9 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	-0.44464544943923445	[2873]	[623,708]	-3	hSpCas9	negative selection	1145126
26051119	26051142	21	-	26627737	RPE1	viability after 9 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	2.495688671310756	[73]	[86,186]	9	hSpCas9	negative selection	1145127
26053305	26053328	21	+	26627737	RPE1	viability after 9 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.25850770156500125	[1211]	[373,556]	1	hSpCas9	negative selection	1145128
26089996	26090019	21	-	26627737	RPE1	viability after 9 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.3447806959549149	[2087]	[505,525]	-2	hSpCas9	negative selection	1145129
25982420	25982443	21	-	26627737	RPE1	viability after 12 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.07815102691325387	[799]	[36,379]	0	hSpCas9	negative selection	1227440
26000064	26000087	21	-	26627737	RPE1	viability after 12 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	-0.36014069667270876	[2873]	[518,688]	-2	hSpCas9	negative selection	1227441
26051119	26051142	21	-	26627737	RPE1	viability after 12 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	3.10860263269751	[73]	[136,207]	9	hSpCas9	negative selection	1227442
26053305	26053328	21	+	26627737	RPE1	viability after 12 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.39498214738922743	[1211]	[416,439]	2	hSpCas9	negative selection	1227443
26089996	26090019	21	-	26627737	RPE1	viability after 12 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.30134728702773184	[2087]	[479,428]	-2	hSpCas9	negative selection	1227444
25982420	25982443	21	-	26627737	RPE1	viability after 15 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.43174551553810564	[799]	[37,562]	2	hSpCas9	negative selection	1309755
26000064	26000087	21	-	26627737	RPE1	viability after 15 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	-0.2166912645855681	[2873]	[805,596]	-1	hSpCas9	negative selection	1309756
26051119	26051142	21	-	26627737	RPE1	viability after 15 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	3.3567032108045862	[73]	[217,210]	9	hSpCas9	negative selection	1309757
26053305	26053328	21	+	26627737	RPE1	viability after 15 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.30963277651590215	[1211]	[372,474]	2	hSpCas9	negative selection	1309758
26089996	26090019	21	-	26627737	RPE1	viability after 15 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.1457301612145112	[2087]	[651,419]	-1	hSpCas9	negative selection	1309759
25982420	25982443	21	-	26627737	RPE1	viability after 18 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.986703832204404	[799]	[43,837]	6	hSpCas9	negative selection	1392070
26000064	26000087	21	-	26627737	RPE1	viability after 18 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	-0.44938081682968334	[2873]	[451,691]	-3	hSpCas9	negative selection	1392071
26051119	26051142	21	-	26627737	RPE1	viability after 18 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	2.461512448318686	[73]	[36,187]	9	hSpCas9	negative selection	1392072
26053305	26053328	21	+	26627737	RPE1	viability after 18 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.5938369159736043	[1211]	[395,597]	4	hSpCas9	negative selection	1392073
26089996	26090019	21	-	26627737	RPE1	viability after 18 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.29423484681601386	[2087]	[503,411]	-2	hSpCas9	negative selection	1392074
25982420	25982443	21	-	26627737	HeLa	viability after 8 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.18349893807382073	[470]	[202,304,186]	1	hSpCas9	negative selection	1474385
26000064	26000087	21	-	26627737	HeLa	viability after 8 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	0.4556844515982543	[823]	[950,262,370]	4	hSpCas9	negative selection	1474386
26051119	26051142	21	-	26627737	HeLa	viability after 8 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	0.333761187906482	[349]	[219,184,177]	3	hSpCas9	negative selection	1474387
26053305	26053328	21	+	26627737	HeLa	viability after 8 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.06409779781731945	[526]	[276,100,341]	0	hSpCas9	negative selection	1474388
26089996	26090019	21	-	26627737	HeLa	viability after 8 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.48885533868611086	[1094]	[468,429,160]	-5	hSpCas9	negative selection	1474389
25982420	25982443	21	-	26627737	HeLa	viability after 12 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.48776920207897434	[470]	[176,124,116]	-4	hSpCas9	negative selection	1556700
26000064	26000087	21	-	26627737	HeLa	viability after 12 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	0.3375043151961823	[823]	[480,338,481]	3	hSpCas9	negative selection	1556701
26051119	26051142	21	-	26627737	HeLa	viability after 12 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	-0.107174059241256	[349]	[83,222,84]	-1	hSpCas9	negative selection	1556702
26053305	26053328	21	+	26627737	HeLa	viability after 12 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.24068659009569277	[526]	[227,286,252]	2	hSpCas9	negative selection	1556703
26089996	26090019	21	-	26627737	HeLa	viability after 12 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.5199775863169914	[1094]	[185,456,284]	-5	hSpCas9	negative selection	1556704
25982420	25982443	21	-	26627737	HeLa	viability after 15 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.22491103281643834	[470]	[144,224,118]	-2	hSpCas9	negative selection	1639015
26000064	26000087	21	-	26627737	HeLa	viability after 15 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	0.9285208590142067	[823]	[800,501,607]	7	hSpCas9	negative selection	1639016
26051119	26051142	21	-	26627737	HeLa	viability after 15 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	0.14195256806637224	[349]	[85,187,201]	1	hSpCas9	negative selection	1639017
26053305	26053328	21	+	26627737	HeLa	viability after 15 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	-0.09344693851719554	[526]	[131,127,355]	-1	hSpCas9	negative selection	1639018
26089996	26090019	21	-	26627737	HeLa	viability after 15 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.06754066477283982	[1094]	[401,333,549]	0	hSpCas9	negative selection	1639019
25982420	25982443	21	-	26627737	HeLa	viability after 18 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.16615707713567307	[470]	[101,196,118]	-1	hSpCas9	negative selection	1721330
26000064	26000087	21	-	26627737	HeLa	viability after 18 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	0.9217906076475164	[823]	[524,423,607]	7	hSpCas9	negative selection	1721331
26051119	26051142	21	-	26627737	HeLa	viability after 18 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	0.17350386108625246	[349]	[60,159,201]	1	hSpCas9	negative selection	1721332
26053305	26053328	21	+	26627737	HeLa	viability after 18 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	-0.08226864205619894	[526]	[85,112,355]	0	hSpCas9	negative selection	1721333
26089996	26090019	21	-	26627737	HeLa	viability after 18 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.04363945719731732	[1094]	[279,280,549]	0	hSpCas9	negative selection	1721334
25982420	25982443	21	-	26627737	HCT116	viability after 6 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	2.171780852301944	[138]	[140,74]	9	hSpCas9	negative selection	1803645
26000064	26000087	21	-	26627737	HCT116	viability after 6 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	-0.5918994905422517	[1161]	[126,117]	-3	hSpCas9	negative selection	1803646
26051119	26051142	21	-	26627737	HCT116	viability after 6 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	-2.408978047090261	[463]	[5,17]	-8	hSpCas9	negative selection	1803647
26053305	26053328	21	+	26627737	HCT116	viability after 6 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	1.3397246595258854	[432]	[34,247]	7	hSpCas9	negative selection	1803648
26089996	26090019	21	-	26627737	HCT116	viability after 6 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	0.6176776749255032	[1138]	[587,101]	3	hSpCas9	negative selection	1803649
25982420	25982443	21	-	26627737	HCT116	viability after 8 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.37214875662739916	[221]	[149,97,225]	4	hSpCas9	negative selection	1885960
26000064	26000087	21	-	26627737	HCT116	viability after 8 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	0.7095526094173308	[411]	[447,285,380]	6	hSpCas9	negative selection	1885961
26051119	26051142	21	-	26627737	HCT116	viability after 8 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	1.5032705556727703	[84]	[119,136,140]	9	hSpCas9	negative selection	1885962
26053305	26053328	21	+	26627737	HCT116	viability after 8 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.19483835949474254	[331]	[207,197,221]	2	hSpCas9	negative selection	1885963
26089996	26090019	21	-	26627737	HCT116	viability after 8 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	0.02645562445183469	[566]	[322,335,295]	0	hSpCas9	negative selection	1885964
25982420	25982443	21	-	26627737	HCT116	viability after 9 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	2.6348690208076695	[138]	[172,275]	9	hSpCas9	negative selection	1968275
26000064	26000087	21	-	26627737	HCT116	viability after 9 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	-0.1453854144991873	[1161]	[222,325]	-1	hSpCas9	negative selection	1968276
26051119	26051142	21	-	26627737	HCT116	viability after 9 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	-0.8074605976655229	[463]	[67,72]	-5	hSpCas9	negative selection	1968277
26053305	26053328	21	+	26627737	HCT116	viability after 9 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	1.0103948114106283	[432]	[228,235]	7	hSpCas9	negative selection	1968278
26089996	26090019	21	-	26627737	HCT116	viability after 9 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	1.5179368434978224	[1138]	[460,1194]	8	hSpCas9	negative selection	1968279
25982420	25982443	21	-	26627737	HCT116	viability after 12 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.22937451107711615	[221]	[95,63,137]	-2	hSpCas9	negative selection	2050590
26000064	26000087	21	-	26627737	HCT116	viability after 12 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	0.830421327518583	[411]	[505,326,309]	7	hSpCas9	negative selection	2050591
26051119	26051142	21	-	26627737	HCT116	viability after 12 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	0.5080808112758055	[84]	[49,72,68]	5	hSpCas9	negative selection	2050592
26053305	26053328	21	+	26627737	HCT116	viability after 12 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.7590979775555706	[331]	[235,374,281]	6	hSpCas9	negative selection	2050593
26089996	26090019	21	-	26627737	HCT116	viability after 12 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	0.29460638085224844	[566]	[316,542,244]	3	hSpCas9	negative selection	2050594
25982420	25982443	21	-	26627737	HCT116	viability after 15 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.07811338379754879	[221]	[89,145,161]	0	hSpCas9	negative selection	2132905
26000064	26000087	21	-	26627737	HCT116	viability after 15 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	1.1518198340566093	[411]	[594,495,494]	8	hSpCas9	negative selection	2132906
26051119	26051142	21	-	26627737	HCT116	viability after 15 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	0.4512378441911373	[84]	[90,30,80]	4	hSpCas9	negative selection	2132907
26053305	26053328	21	+	26627737	HCT116	viability after 15 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.2703146591570375	[331]	[309,191,197]	2	hSpCas9	negative selection	2132908
26089996	26090019	21	-	26627737	HCT116	viability after 15 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	0.2577404974767522	[566]	[274,568,310]	2	hSpCas9	negative selection	2132909
25982420	25982443	21	-	26627737	HCT116	viability after 18 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.23761113776356427	[221]	[148,96,135]	2	hSpCas9	negative selection	2215220
26000064	26000087	21	-	26627737	HCT116	viability after 18 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	0.8747235933553148	[411]	[318,295,490]	7	hSpCas9	negative selection	2215221
26051119	26051142	21	-	26627737	HCT116	viability after 18 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	0.4224061895899116	[84]	[42,78,40]	3	hSpCas9	negative selection	2215222
26053305	26053328	21	+	26627737	HCT116	viability after 18 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.41716642494557515	[331]	[209,232,197]	3	hSpCas9	negative selection	2215223
26089996	26090019	21	-	26627737	HCT116	viability after 18 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.008591358078341327	[566]	[265,321,223]	0	hSpCas9	negative selection	2215224
26089936	26089959	21	+	24336569	HL60	viability	GGCTCACCTAAGCAGCGGTAGGG	APP	ENSG00000142192	0.954503621719941	[306]	[1258]	7	hSpCas9	negative selection	2248258
26089942	26089965	21	-	24336569	HL60	viability	GTGATTCCCTACCGCTGCTTAGG	APP	ENSG00000142192	0.12727816011043402	[712]	[1647]	1	hSpCas9	negative selection	2248259
26089949	26089972	21	+	24336569	HL60	viability	AGCGGTAGGGAATCACAAAGTGG	APP	ENSG00000142192	1.6484467360033592	[204]	[1359]	9	hSpCas9	negative selection	2248260
26089973	26089996	21	+	24336569	HL60	viability	GATGGGTCTTGCACTGCTTGCGG	APP	ENSG00000142192	0.6013457234904046	[246]	[792]	5	hSpCas9	negative selection	2248261
26089997	26090020	21	-	24336569	HL60	viability	CATCCAGAACTGGTGCAAGCGGG	APP	ENSG00000142192	0.13834168614483056	[318]	[742]	1	hSpCas9	negative selection	2248262
26090005	26090028	21	+	24336569	HL60	viability	CACCAGTTCTGGATGGTCACTGG	APP	ENSG00000142192	0.04793437348398333	[713]	[1561]	0	hSpCas9	negative selection	2248263
26090013	26090036	21	+	24336569	HL60	viability	CTGGATGGTCACTGGTTGGTTGG	APP	ENSG00000142192	-0.8786203725459694	[880]	[1013]	-7	hSpCas9	negative selection	2248264
26090028	26090051	21	+	24336569	HL60	viability	TTGGTTGGCTTCTACCACATTGG	APP	ENSG00000142192	2.876307663981806	[38]	[605]	9	hSpCas9	negative selection	2248265
26090042	26090065	21	-	24336569	HL60	viability	TGAACTGCAGATCACCAATGTGG	APP	ENSG00000142192	-0.2252998732025478	[547]	[991]	-2	hSpCas9	negative selection	2248266
26090054	26090077	21	+	24336569	HL60	viability	TCTGCAGTTCAGGGTAGACCTGG	APP	ENSG00000142192	1.1136209747118162	[479]	[2197]	8	hSpCas9	negative selection	2248267
26089936	26089959	21	+	24336569	KBM7	viability	GGCTCACCTAAGCAGCGGTAGGG	APP	ENSG00000142192	0.28296853653111925	[382]	[1270]	2	hSpCas9	negative selection	2315435
26089942	26089965	21	-	24336569	KBM7	viability	GTGATTCCCTACCGCTGCTTAGG	APP	ENSG00000142192	0.35900935362303016	[537]	[1881]	3	hSpCas9	negative selection	2315436
26089949	26089972	21	+	24336569	KBM7	viability	AGCGGTAGGGAATCACAAAGTGG	APP	ENSG00000142192	0.11611468741862244	[409]	[1211]	1	hSpCas9	negative selection	2315437
26089973	26089996	21	+	24336569	KBM7	viability	GATGGGTCTTGCACTGCTTGCGG	APP	ENSG00000142192	0.8367893509637874	[357]	[1743]	7	hSpCas9	negative selection	2315438
26089997	26090020	21	-	24336569	KBM7	viability	CATCCAGAACTGGTGCAAGCGGG	APP	ENSG00000142192	0.4483351708169397	[430]	[1603]	4	hSpCas9	negative selection	2315439
26090005	26090028	21	+	24336569	KBM7	viability	CACCAGTTCTGGATGGTCACTGG	APP	ENSG00000142192	-0.04975625262223829	[410]	[1082]	0	hSpCas9	negative selection	2315440
26090013	26090036	21	+	24336569	KBM7	viability	CTGGATGGTCACTGGTTGGTTGG	APP	ENSG00000142192	1.8267062090615738	[156]	[1518]	9	hSpCas9	negative selection	2315441
26090028	26090051	21	+	24336569	KBM7	viability	TTGGTTGGCTTCTACCACATTGG	APP	ENSG00000142192	0.5366534875928008	[183]	[727]	5	hSpCas9	negative selection	2315442
26090042	26090065	21	-	24336569	KBM7	viability	TGAACTGCAGATCACCAATGTGG	APP	ENSG00000142192	0.1880093772422416	[307]	[956]	1	hSpCas9	negative selection	2315443
26090054	26090077	21	+	24336569	KBM7	viability	TCTGCAGTTCAGGGTAGACCTGG	APP	ENSG00000142192	0.6518712088179067	[563]	[2416]	6	hSpCas9	negative selection	2315444
26140504	26140527	21	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGCACAAAGCCAAGTGTCAGGGG	APP	ENSG00000142192	0.2370886015876293	[91,21]	[9,18]	1	dCas9-VP64	positive selection	2399620
26140525	26140548	21	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGCTGTGGAGAAGGAACTGCTGG	APP	ENSG00000142192	1.0224183962744713	[68,21]	[6,33]	4	dCas9-VP64	positive selection	2399621
26140548	26140571	21	-	25494202	A375	resistance to PLX-4720 (puromycin)	GTCAACCTTGGATGGAATTTGGG	APP	ENSG00000142192	-0.4469283325863789	[204,385]	[9,87]	-2	dCas9-VP64	positive selection	2399622
26082191	26082214	21	-	25494202	A375	resistance to PLX-4720 (puromycin)	GAGTTTCACTCTTGTTGCCCCGG	APP	ENSG00000142192	1.0342323942437988	[48,24]	[15,15]	4	dCas9-VP64	positive selection	2423100
25890461	25890484	21	-	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCGTGAGCCACCGCGTCTGG	APP	ENSG00000142192	-0.7423063429264437	[17,121]	[9,7]	-4	dCas9-VP64	positive selection	2425743
26139642	26139665	21	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCCAGCACTTTAGGAGGCCGAGG	APP	ENSG00000142192	-1.9053815531021414	[9,238]	[3,9]	-9	dCas9-VP64	positive selection	2432842
25971321	25971344	21	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCGTGAGCCACCACACCTGG	APP	ENSG00000142192	0.08350517940301261	[638,11]	[141,1]	0	dCas9-VP64	positive selection	2447574
26084378	26084401	21	+	25494202	A375	resistance to PLX-4720 (puromycin)	ACAGGCGCCCGCACCACGCCTGG	APP	ENSG00000142192	1.6828631382082904	[88,96]	[105,22]	6	dCas9-VP64	positive selection	2453007
26084497	26084520	21	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGCCTGTAATCCCAGAACTTCGG	APP	ENSG00000142192	-2.543268417376507	[115,242]	[7,4]	-9	dCas9-VP64	positive selection	2456199
25973898	25973921	21	-	25494202	A375	resistance to PLX-4720 (puromycin)	TCACCCAGGCTGGAGTGCAGTGG	APP	ENSG00000142192	-0.014347572194705283	[459,63]	[82,26]	0	dCas9-VP64	positive selection	2457977
26118590	26118613	21	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCGCCCAGGCTGGAGTGCAGCGG	APP	ENSG00000142192	0.5070772209909733	[97,61]	[39,7]	2	dCas9-VP64	positive selection	2477677
26140504	26140527	21	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGCACAAAGCCAAGTGTCAGGGG	APP	ENSG00000142192	-0.7735996315038631	[77,87]	[17,12]	-7	dCas9-VP64	positive selection	2494875
26140525	26140548	21	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGCTGTGGAGAAGGAACTGCTGG	APP	ENSG00000142192	-0.2983874421907562	[300,383]	[43,133]	-3	dCas9-VP64	positive selection	2494876
26140548	26140571	21	-	25494202	A375	resistance to PLX-4720 (zeocin)	GTCAACCTTGGATGGAATTTGGG	APP	ENSG00000142192	-0.28355863538712855	[197,121]	[68,18]	-3	dCas9-VP64	positive selection	2494877
26082191	26082214	21	-	25494202	A375	resistance to PLX-4720 (zeocin)	GAGTTTCACTCTTGTTGCCCCGG	APP	ENSG00000142192	1.1207783393058013	[70,52]	[75,13]	7	dCas9-VP64	positive selection	2518355
25890461	25890484	21	-	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCGTGAGCCACCGCGTCTGG	APP	ENSG00000142192	0.04080549521603816	[105,72]	[24,33]	0	dCas9-VP64	positive selection	2520998
26139642	26139665	21	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCCAGCACTTTAGGAGGCCGAGG	APP	ENSG00000142192	-0.09783295340008746	[47,55]	[20,9]	-1	dCas9-VP64	positive selection	2528097
25971321	25971344	21	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCGTGAGCCACCACACCTGG	APP	ENSG00000142192	-0.14914508695783546	[201,22]	[49,17]	-1	dCas9-VP64	positive selection	2542829
26084378	26084401	21	+	25494202	A375	resistance to PLX-4720 (zeocin)	ACAGGCGCCCGCACCACGCCTGG	APP	ENSG00000142192	-0.04995581093037604	[128,181]	[37,58]	0	dCas9-VP64	positive selection	2548262
26084497	26084520	21	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGCCTGTAATCCCAGAACTTCGG	APP	ENSG00000142192	-0.5948923258591747	[103,174]	[39,19]	-6	dCas9-VP64	positive selection	2551454
25973898	25973921	21	-	25494202	A375	resistance to PLX-4720 (zeocin)	TCACCCAGGCTGGAGTGCAGTGG	APP	ENSG00000142192	-0.8839666549432982	[334,175]	[40,48]	-8	dCas9-VP64	positive selection	2553232
26118590	26118613	21	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCGCCCAGGCTGGAGTGCAGCGG	APP	ENSG00000142192	-0.06949214303462026	[365,454]	[80,170]	0	dCas9-VP64	positive selection	2572932
26051124	26051147	21	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CGGAACTTGTCAATTCCGCAGGG	APP	ENSG00000142192	-0.9963765320264435	[2,2]	[1,0]	-9	hSpCas9	positive selection	2971061
26051118	26051141	21	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CGGAATTGACAAGTTCCGAGGGG	APP	ENSG00000142192	0.42924304707433153	[2,2]	[4,2]	8	hSpCas9	positive selection	2971062
26089932	26089955	21	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.0279139981459752	[3,2]	[4,0]	0	hSpCas9	positive selection	2971063
26053306	26053329	21	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.6672547650817229	[2,2]	[3,3]	9	hSpCas9	positive selection	2971064
26051124	26051147	21	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CGGAACTTGTCAATTCCGCAGGG	APP	ENSG00000142192	0.2108638769637161	[2,2]	[2,1]	4	hSpCas9	positive selection	3038919
26051118	26051141	21	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CGGAATTGACAAGTTCCGAGGGG	APP	ENSG00000142192	-0.8712044923623312	[2,2]	[1,0]	-9	hSpCas9	positive selection	3038920
26089932	26089955	21	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.381943873294452	[3,3]	[1,3]	6	hSpCas9	positive selection	3038921
26053306	26053329	21	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.3528451419884041	[2,2]	[2,1]	6	hSpCas9	positive selection	3038922
25975961	25975984		+	24336571	A375	resistance to PLX after 7 days	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	-0.07803886925902548	[202,208]	[192,194]	-2	hSpCas9	positive selection	3124528
25975965	25975988		-	24336571	A375	resistance to PLX after 7 days	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.10039386529433614	[31,33]	[34,34]	3	hSpCas9	positive selection	3124539
25982420	25982443		-	24336571	A375	resistance to PLX after 7 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.02071492520034246	[94,90]	[90,95]	0	hSpCas9	positive selection	3124550
25982425	25982448		+	24336571	A375	resistance to PLX after 7 days	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.134104151778784	[112,108]	[121,119]	4	hSpCas9	positive selection	3124561
25975961	25975984		+	24336571	A375	resistance to PLX after 14 days	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	-0.2575491449758829	[188,197]	[75,73]	-3	hSpCas9	positive selection	3182321
25975965	25975988		-	24336571	A375	resistance to PLX after 14 days	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.543591662214963	[31,30]	[18,22]	5	hSpCas9	positive selection	3182332
25982420	25982443		-	24336571	A375	resistance to PLX after 14 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.32441428376251347	[95,86]	[32,34]	-4	hSpCas9	positive selection	3182343
25982425	25982448		+	24336571	A375	resistance to PLX after 14 days	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.807678690705786	[102,104]	[95,73]	6	hSpCas9	positive selection	3182354
25975961	25975984		+	24336571	A375	viability after 7 days	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.6039577625666879	[141]	[202,208]	8	hSpCas9	negative selection	3240114
25975965	25975988		-	24336571	A375	viability after 7 days	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.5141324991965772	[48]	[31,33]	-6	hSpCas9	negative selection	3240125
25982420	25982443		-	24336571	A375	viability after 7 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	1.4151057234731395	[35]	[94,90]	9	hSpCas9	negative selection	3240136
25982425	25982448		+	24336571	A375	viability after 7 days	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	1.9151244071241718	[30]	[112,108]	9	hSpCas9	negative selection	3240147
25975961	25975984		+	24336571	A375	viability after 14 days	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.5273819908243471	[141]	[188,197]	6	hSpCas9	negative selection	3297907
25975965	25975988		-	24336571	A375	viability after 14 days	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.5595600211606635	[48]	[31,30]	-6	hSpCas9	negative selection	3297918
25982420	25982443		-	24336571	A375	viability after 14 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	1.4146455972937988	[35]	[95,86]	9	hSpCas9	negative selection	3297929
25982425	25982448		+	24336571	A375	viability after 14 days	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	1.8427266768648893	[30]	[102,104]	9	hSpCas9	negative selection	3297940
25975084	25975107	21	-	27383988	293T	resistance to West Nile virus (flavivirus)	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	-1.42972349543221	[435,387]	[0,0]	-8	hSpCas9	positive selection	3337109
25982420	25982443	21	-	27383988	293T	resistance to West Nile virus (flavivirus)	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.21829966670256493	[132,129]	[0,0]	1	hSpCas9	positive selection	3337110
25982425	25982448	21	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	-0.4068479845156569	[177,227]	[0,0]	-3	hSpCas9	positive selection	3337111
25975114	25975137	21	-	27383988	293T	resistance to West Nile virus (flavivirus)	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	1.399345216318263	[57,57]	[0,0]	6	hSpCas9	positive selection	3356355
25975965	25975988	21	-	27383988	293T	resistance to West Nile virus (flavivirus)	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	2.3031299010589596	[30,30]	[0,0]	8	hSpCas9	positive selection	3356356
25975961	25975984	21	+	27383988	293T	resistance to West Nile virus (flavivirus)	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	1.291541926783748	[124,124]	[1,1]	5	hSpCas9	positive selection	3356357
26051123	26051146	21	+	26780180	HT29	viability (Avana library 4 designs)	CGGAACTTGTCAATTCCGCAGGG	APP	ENSG00000142192	1.90258534687113	[]	[]	7	hSpCas9	negative selection	3407169
26051118	26051141	21	-	26780180	HT29	viability (Avana library 4 designs)	CGGAATTGACAAGTTCCGAGGGG	APP	ENSG00000142192	1.79499336063183	[]	[]	6	hSpCas9	negative selection	3407170
26089931	26089954	21	+	26780180	HT29	viability (Avana library 4 designs)	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	2.44545222720746	[]	[]	8	hSpCas9	negative selection	3407171
26053305	26053328	21	+	26780180	HT29	viability (Avana library 4 designs)	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	2.20617027517687	[]	[]	7	hSpCas9	negative selection	3407172
26051123	26051146	21	+	26780180	A375	viability (Avana lentiCRISPRv2)	CGGAACTTGTCAATTCCGCAGGG	APP	ENSG00000142192	5.73143287623949	[]	[]	9	hSpCas9	negative selection	3480085
26051118	26051141	21	-	26780180	A375	viability (Avana lentiCRISPRv2)	CGGAATTGACAAGTTCCGAGGGG	APP	ENSG00000142192	3.9300626584437	[]	[]	6	hSpCas9	negative selection	3480086
26053305	26053328	21	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	-1.52252878987201	[]	[]	-2	hSpCas9	negative selection	3480087
26089931	26089954	21	+	26780180	A375	viability (Avana lentiCRISPRv2)	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	2.2875362206517	[]	[]	3	hSpCas9	negative selection	3480088
26050999	26051022	21	-	26780180	A375	viability (Avana lentiCRISPRv2)	ACACAGACTATGCAGATGGGAGG	APP	ENSG00000142192	6.40444542526577	[]	[]	9	hSpCas9	negative selection	3480089
26051003	26051026	21	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGACACAGACTATGCAGATGG	APP	ENSG00000142192	3.67648757878683	[]	[]	6	hSpCas9	negative selection	3480090
26051123	26051146	21	+	26780180	A375	viability (Avana lentiGuide)	CGGAACTTGTCAATTCCGCAGGG	APP	ENSG00000142192	0.756763782571987	[]	[]	0	hSpCas9	negative selection	3588744
26051118	26051141	21	-	26780180	A375	viability (Avana lentiGuide)	CGGAATTGACAAGTTCCGAGGGG	APP	ENSG00000142192	-3.80511398228232	[]	[]	-6	hSpCas9	negative selection	3588745
26053305	26053328	21	+	26780180	A375	viability (Avana lentiGuide)	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	4.33615551396626	[]	[]	4	hSpCas9	negative selection	3588746
26089931	26089954	21	+	26780180	A375	viability (Avana lentiGuide)	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	-1.51346970019804	[]	[]	-2	hSpCas9	negative selection	3588747
26050999	26051022	21	-	26780180	A375	viability (Avana lentiGuide)	ACACAGACTATGCAGATGGGAGG	APP	ENSG00000142192	-5.80520940857215	[]	[]	-8	hSpCas9	negative selection	3588748
26051003	26051026	21	-	26780180	A375	viability (Avana lentiGuide)	GCAGACACAGACTATGCAGATGG	APP	ENSG00000142192	-4.59539968802195	[]	[]	-7	hSpCas9	negative selection	3588749
26051123	26051146	21	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CGGAACTTGTCAATTCCGCAGGG	APP	ENSG00000142192	-0.08217340043206414	[4]	[4,3]	-1	hSpCas9	positive selection	3697403
26051118	26051141	21	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CGGAATTGACAAGTTCCGAGGGG	APP	ENSG00000142192	-0.04815180465088327	[4]	[5,3]	-1	hSpCas9	positive selection	3697404
26053305	26053328	21	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	-0.6998828399145179	[4]	[2,1]	-7	hSpCas9	positive selection	3697405
26089931	26089954	21	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.3275232226610175	[4]	[4,5]	8	hSpCas9	positive selection	3697406
26050999	26051022	21	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ACACAGACTATGCAGATGGGAGG	APP	ENSG00000142192	0.36566608971457387	[5]	[6,6]	9	hSpCas9	positive selection	3697407
26051003	26051026	21	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGACACAGACTATGCAGATGG	APP	ENSG00000142192	0.07509131912112364	[4]	[5,4]	2	hSpCas9	positive selection	3697408
26051123	26051146	21	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CGGAACTTGTCAATTCCGCAGGG	APP	ENSG00000142192	0.045543698785716694	[4]	[4,3]	1	hSpCas9	positive selection	3806010
26051118	26051141	21	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CGGAATTGACAAGTTCCGAGGGG	APP	ENSG00000142192	-1.2372482983504502	[4]	[0,1]	-9	hSpCas9	positive selection	3806011
26053305	26053328	21	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	-0.2593000075954341	[4]	[4,0]	-4	hSpCas9	positive selection	3806012
26089931	26089954	21	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.21744005301721156	[4]	[4,4]	5	hSpCas9	positive selection	3806013
26050999	26051022	21	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ACACAGACTATGCAGATGGGAGG	APP	ENSG00000142192	0.06740277542872028	[5]	[4,4]	1	hSpCas9	positive selection	3806014
26051003	26051026	21	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGACACAGACTATGCAGATGG	APP	ENSG00000142192	0.3129907841560816	[4]	[5,4]	8	hSpCas9	positive selection	3806015
25975961	25975984	21	+	26780180	A375	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.444007170459641	[]	[]	1	hSpCas9	negative selection	3914277
25975965	25975988	21	-	26780180	A375	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.731704199277633	[]	[]	2	hSpCas9	negative selection	3914278
25975084	25975107	21	-	26780180	A375	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.742032110677849	[]	[]	2	hSpCas9	negative selection	3914279
25982420	25982443	21	-	26780180	A375	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	1.14515692566399	[]	[]	6	hSpCas9	negative selection	3914280
25975114	25975137	21	-	26780180	A375	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.244687266775944	[]	[]	0	hSpCas9	negative selection	3914281
25982425	25982448	21	+	26780180	A375	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	1.13029211693834	[]	[]	5	hSpCas9	negative selection	3914282
25975961	25975984	21	+	26780180	HT29	viability (GeCKOv2 library)	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	1.37811440221948	[]	[]	7	hSpCas9	negative selection	4022243
25975965	25975988	21	-	26780180	HT29	viability (GeCKOv2 library)	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	1.68568559805815	[]	[]	8	hSpCas9	negative selection	4022244
25975084	25975107	21	-	26780180	HT29	viability (GeCKOv2 library)	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.151175809080262	[]	[]	0	hSpCas9	negative selection	4022245
25982420	25982443	21	-	26780180	HT29	viability (GeCKOv2 library)	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	2.09482819792325	[]	[]	9	hSpCas9	negative selection	4022246
25975114	25975137	21	-	26780180	HT29	viability (GeCKOv2 library)	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	1.042944102696	[]	[]	5	hSpCas9	negative selection	4022247
25982425	25982448	21	+	26780180	HT29	viability (GeCKOv2 library)	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.685490727932601	[]	[]	2	hSpCas9	negative selection	4022248
25975961	25975984	21	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.3141852232307767	[7]	[6,6]	7	hSpCas9	positive selection	4148590
25975965	25975988	21	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.2985561647234272	[4]	[3,4]	7	hSpCas9	positive selection	4148601
25982420	25982443	21	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.3113520084930993	[6]	[6,5]	7	hSpCas9	positive selection	4148612
25982425	25982448	21	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.2977610975072966	[6]	[5,6]	7	hSpCas9	positive selection	4148623
25975961	25975984	21	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	1.1150883943433194	[7]	[7,6,5,7]	8	hSpCas9	positive selection	4212612
25975965	25975988	21	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.06399131475093389	[6]	[4,5,3,0]	0	hSpCas9	positive selection	4212623
25982420	25982443	21	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	1.1307065949395436	[6]	[5,4,6,5]	8	hSpCas9	positive selection	4212634
25982425	25982448	21	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	1.219382972206525	[6]	[5,5,8,5]	8	hSpCas9	positive selection	4212645
25975084	25975107	21	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.28971905234435547	[4]	[5,3]	6	hSpCas9	positive selection	4256261
25982420	25982443	21	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.18534301878251208	[2]	[2,2]	4	hSpCas9	positive selection	4256262
25982425	25982448	21	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.44159567020583446	[3]	[3,3]	8	hSpCas9	positive selection	4256263
25975114	25975137	21	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.17413927537510032	[1]	[2,0]	3	hSpCas9	positive selection	4320545
25975965	25975988	21	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.9246682136853516	[1]	[0,0]	-9	hSpCas9	positive selection	4320546
25975961	25975984	21	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.41260902727984733	[1]	[2,1]	8	hSpCas9	positive selection	4320547
26051123	26051145	21	+	27760321	OCIAML3	viability	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	0.39271483438499905	[418,414]	[352,528]	5	hSpCas9	negative selection	4378835
26051153	26051175	21	+	27760321	OCIAML3	viability	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	0.07629129645397752	[449,390]	[344,346]	0	hSpCas9	negative selection	4378836
26053235	26053257	21	-	27760321	OCIAML3	viability	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	0.0773892546464302	[489,382]	[365,346]	0	hSpCas9	negative selection	4378837
26089936	26089958	21	+	27760321	OCIAML3	viability	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	0.5891230895680745	[558,469]	[635,559]	7	hSpCas9	negative selection	4378838
25982426	25982448	21	+	27760321	OCIAML3	viability	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.019152526936975	[159,143]	[115,125]	0	hSpCas9	negative selection	4378839
26051123	26051145	21	+	27760321	OCIAML2	viability	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	0.4080521923441469	[418,414]	[441,457]	5	hSpCas9	negative selection	4462298
26051153	26051175	21	+	27760321	OCIAML2	viability	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	0.22968584667660036	[449,390]	[330,485]	3	hSpCas9	negative selection	4462299
26053235	26053257	21	-	27760321	OCIAML2	viability	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	-0.4772254198689293	[489,382]	[197,322]	-5	hSpCas9	negative selection	4462300
26089936	26089958	21	+	27760321	OCIAML2	viability	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	-0.06314443900181785	[558,469]	[332,480]	-1	hSpCas9	negative selection	4462301
25982426	25982448	21	+	27760321	OCIAML2	viability	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	1.034230305566693	[159,143]	[251,250]	9	hSpCas9	negative selection	4462302
26051123	26051145	21	+	27760321	MV411	viability	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	1.0947095506818676	[418,414]	[345,954]	7	hSpCas9	negative selection	4545761
26051153	26051175	21	+	27760321	MV411	viability	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	0.8104734253424585	[449,390]	[305,754]	6	hSpCas9	negative selection	4545762
26053235	26053257	21	-	27760321	MV411	viability	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	-0.49345798720532963	[489,382]	[225,168]	-3	hSpCas9	negative selection	4545763
26089936	26089958	21	+	27760321	MV411	viability	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	0.38235680817561624	[558,469]	[517,324]	2	hSpCas9	negative selection	4545764
25982426	25982448	21	+	27760321	MV411	viability	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	1.5722629335072815	[159,143]	[259,354]	9	hSpCas9	negative selection	4545765
26051123	26051145	21	+	27760321	HL60	viability	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	0.4816750472662901	[418,414]	[477,475]	6	hSpCas9	negative selection	4629224
26051153	26051175	21	+	27760321	HL60	viability	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	0.21004242723209227	[449,390]	[324,471]	2	hSpCas9	negative selection	4629225
26053235	26053257	21	-	27760321	HL60	viability	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	0.5880162724074566	[489,382]	[543,519]	7	hSpCas9	negative selection	4629226
26089936	26089958	21	+	27760321	HL60	viability	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	0.39544913221819966	[558,469]	[507,595]	5	hSpCas9	negative selection	4629227
25982426	25982448	21	+	27760321	HL60	viability	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	2.127637212514223	[159,143]	[559,522]	9	hSpCas9	negative selection	4629228
26051123	26051145	21	+	27760321	HT1080	viability	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	-0.5291685453413063	[414,323]	[80,124]	-2	hSpCas9	negative selection	4712687
26051153	26051175	21	+	27760321	HT1080	viability	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	1.7232791743868567	[390,304]	[430,486]	8	hSpCas9	negative selection	4712688
26053235	26053257	21	-	27760321	HT1080	viability	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	1.1148281817365977	[382,298]	[308,277]	6	hSpCas9	negative selection	4712689
26089936	26089958	21	+	27760321	HT1080	viability	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	-0.32542404828648996	[469,366]	[207,50]	-1	hSpCas9	negative selection	4712690
25982426	25982448	21	+	27760321	HT1080	viability	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	1.7280189243028508	[143,112]	[161,177]	8	hSpCas9	negative selection	4712691
26051123	26051145	21	+	27760321	HT29	viability after 7 days	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	-0.4584589423845774	[414,323]	[366,397,276]	-6	hSpCas9	negative selection	4796150
26051153	26051175	21	+	27760321	HT29	viability after 7 days	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	0.009602566059236567	[390,304]	[522,485,354]	0	hSpCas9	negative selection	4796151
26053235	26053257	21	-	27760321	HT29	viability after 7 days	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	0.15457871685939384	[382,298]	[472,556,432]	2	hSpCas9	negative selection	4796152
26089936	26089958	21	+	27760321	HT29	viability after 7 days	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	0.2855222091918812	[469,366]	[724,612,638]	4	hSpCas9	negative selection	4796153
25982426	25982448	21	+	27760321	HT29	viability after 7 days	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.3428705466182487	[143,112]	[367,101,181]	5	hSpCas9	negative selection	4796154
26051123	26051145	21	+	27760321	HT29	viability after 25 days	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	-0.01533907932192384	[414,323]	[316,430,521]	0	hSpCas9	negative selection	4879613
26051153	26051175	21	+	27760321	HT29	viability after 25 days	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	0.7322456037557983	[390,304]	[526,735,733]	8	hSpCas9	negative selection	4879614
26053235	26053257	21	-	27760321	HT29	viability after 25 days	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	0.5130719094248248	[382,298]	[468,665,535]	5	hSpCas9	negative selection	4879615
26089936	26089958	21	+	27760321	HT29	viability after 25 days	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	0.24659738407568024	[469,366]	[536,472,707]	2	hSpCas9	negative selection	4879616
25982426	25982448	21	+	27760321	HT29	viability after 25 days	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.2800437950943613	[143,112]	[157,243,128]	3	hSpCas9	negative selection	4879617
26051123	26051145	21	+	27760321	HT29	viability after 22 days	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	-0.09751395160050647	[414,323]	[368,278,551]	-1	hSpCas9	negative selection	4963076
26051153	26051175	21	+	27760321	HT29	viability after 22 days	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	0.6215969276986065	[390,304]	[589,609,657]	7	hSpCas9	negative selection	4963077
26053235	26053257	21	-	27760321	HT29	viability after 22 days	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	0.48644159859829633	[382,298]	[411,764,482]	5	hSpCas9	negative selection	4963078
26089936	26089958	21	+	27760321	HT29	viability after 22 days	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	0.22910840034323052	[469,366]	[573,566,559]	2	hSpCas9	negative selection	4963079
25982426	25982448	21	+	27760321	HT29	viability after 22 days	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.08971915089451099	[143,112]	[194,162,114]	0	hSpCas9	negative selection	4963080
26051123	26051145	21	+	27760321	HT29	viability after 19 days	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	0.26291269026413094	[414,323]	[553,523,449]	2	hSpCas9	negative selection	5046539
26051153	26051175	21	+	27760321	HT29	viability after 19 days	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	0.9063637011333796	[390,304]	[673,653,895]	8	hSpCas9	negative selection	5046540
26053235	26053257	21	-	27760321	HT29	viability after 19 days	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	-0.06098894312704288	[382,298]	[526,387,227]	0	hSpCas9	negative selection	5046541
26089936	26089958	21	+	27760321	HT29	viability after 19 days	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	-0.0737454611256819	[469,366]	[569,481,328]	0	hSpCas9	negative selection	5046542
25982426	25982448	21	+	27760321	HT29	viability after 19 days	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.7722396362454123	[143,112]	[278,332,147]	7	hSpCas9	negative selection	5046543
26051123	26051145	21	+	27760321	HT29	viability after 16 days	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	0.09545788062868552	[414,323]	[507,412,410]	1	hSpCas9	negative selection	5130002
26051153	26051175	21	+	27760321	HT29	viability after 16 days	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	0.547415856557769	[390,304]	[438,668,583]	6	hSpCas9	negative selection	5130003
26053235	26053257	21	-	27760321	HT29	viability after 16 days	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	0.5381733830722165	[382,298]	[525,565,566]	6	hSpCas9	negative selection	5130004
26089936	26089958	21	+	27760321	HT29	viability after 16 days	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	0.08488788537787509	[469,366]	[532,503,455]	0	hSpCas9	negative selection	5130005
25982426	25982448	21	+	27760321	HT29	viability after 16 days	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.7094055315400826	[143,112]	[274,165,269]	8	hSpCas9	negative selection	5130006
26051123	26051145	21	+	27760321	HT29	viability after 13 days	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	0.01035544234585925	[414,323]	[395,496,403]	0	hSpCas9	negative selection	5213465
26051153	26051175	21	+	27760321	HT29	viability after 13 days	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	0.5528661901459371	[390,304]	[396,752,624]	7	hSpCas9	negative selection	5213466
26053235	26053257	21	-	27760321	HT29	viability after 13 days	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	0.45391859256590683	[382,298]	[626,552,450]	6	hSpCas9	negative selection	5213467
26089936	26089958	21	+	27760321	HT29	viability after 13 days	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	0.027641206712304772	[469,366]	[600,449,436]	0	hSpCas9	negative selection	5213468
25982426	25982448	21	+	27760321	HT29	viability after 13 days	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.6274055774169393	[143,112]	[283,228,180]	7	hSpCas9	negative selection	5213469
26051123	26051145	21	+	27760321	HT29	viability after 10 days	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	-0.14386663468329122	[414,323]	[553,323,372]	-2	hSpCas9	negative selection	5296928
26051153	26051175	21	+	27760321	HT29	viability after 10 days	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	0.1635549776789289	[390,304]	[514,396,543]	2	hSpCas9	negative selection	5296929
26053235	26053257	21	-	27760321	HT29	viability after 10 days	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	0.4817865397764348	[382,298]	[894,447,439]	6	hSpCas9	negative selection	5296930
26089936	26089958	21	+	27760321	HT29	viability after 10 days	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	0.09532135806066858	[469,366]	[518,583,571]	1	hSpCas9	negative selection	5296931
25982426	25982448	21	+	27760321	HT29	viability after 10 days	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.8243196117480137	[143,112]	[411,316,127]	9	hSpCas9	negative selection	5296932
26051123	26051145	21	+	27760321	MOLM13	viability	CGGAACTTGTCAATTCCGCAGG	APP	ENSG00000142192	1.0755392395600087	[418,414]	[412,568]	7	hSpCas9	negative selection	5380391
26051153	26051175	21	+	27760321	MOLM13	viability	ATGCCGTAGTCATGCAAGTTGG	APP	ENSG00000142192	0.645019264403266	[449,390]	[590,181]	4	hSpCas9	negative selection	5380392
26053235	26053257	21	-	27760321	MOLM13	viability	TGGCACACCGTCGCCAAAGAGG	APP	ENSG00000142192	0.7254890336600073	[489,382]	[337,460]	5	hSpCas9	negative selection	5380393
26089936	26089958	21	+	27760321	MOLM13	viability	GGCTCACCTAAGCAGCGGTAGG	APP	ENSG00000142192	0.2346622934571533	[558,469]	[383,302]	1	hSpCas9	negative selection	5380394
25982426	25982448	21	+	27760321	MOLM13	viability	GTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	1.1972174303463543	[159,143]	[277,126]	8	hSpCas9	negative selection	5380395
25975084	25975107	21	-	27260156	BXPC3	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.04563218424229487	[1456]	[1468,1408,1724,1716]	1	hSpCas9	negative selection	5528721
25982420	25982443	21	-	27260156	BXPC3	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.06400893932071863	[442]	[423,483,516,519]	1	hSpCas9	negative selection	5528722
25982425	25982448	21	+	27260156	BXPC3	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.1872930536909908	[551]	[499,696,639,821]	4	hSpCas9	negative selection	5528723
25975114	25975137	21	-	27260156	BXPC3	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.6830511685098071	[139]	[197,221,158,380]	9	hSpCas9	negative selection	5593005
25975965	25975988	21	-	27260156	BXPC3	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.23441586057519692	[164]	[82,155,141,219]	-5	hSpCas9	negative selection	5593006
25975961	25975984	21	+	27260156	BXPC3	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.4003982797643253	[158]	[200,206,222,251]	8	hSpCas9	negative selection	5593007
25975084	25975107	21	-	27260156	A673	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.17801832022111364	[1456]	[2012,1932,2136,1824]	4	hSpCas9	negative selection	5649972
25982420	25982443	21	-	27260156	A673	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.012808444083253753	[442]	[647,504,429,540]	0	hSpCas9	negative selection	5649973
25982425	25982448	21	+	27260156	A673	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.27806417549713314	[551]	[874,756,768,822]	6	hSpCas9	negative selection	5649974
25975114	25975137	21	-	27260156	A673	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.28913151902097933	[139]	[232,181,160,251]	6	hSpCas9	negative selection	5714256
25975965	25975988	21	-	27260156	A673	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.027777161330054145	[164]	[166,191,185,230]	0	hSpCas9	negative selection	5714257
25975961	25975984	21	+	27260156	A673	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.16855820054811854	[158]	[269,151,225,217]	4	hSpCas9	negative selection	5714258
25975084	25975107	21	-	27260156	A375	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.2561387829760724	[1456]	[2047,1695,2243,2080]	4	hSpCas9	negative selection	5771223
25982420	25982443	21	-	27260156	A375	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.015554957971625552	[442]	[338,728,522,525]	0	hSpCas9	negative selection	5771224
25982425	25982448	21	+	27260156	A375	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.17848245997801687	[551]	[514,877,915,636]	2	hSpCas9	negative selection	5771225
25975114	25975137	21	-	27260156	A375	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.8282860856794891	[139]	[166,271,447,271]	9	hSpCas9	negative selection	5835507
25975965	25975988	21	-	27260156	A375	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.3588977737165626	[164]	[178,143,127,148]	-5	hSpCas9	negative selection	5835508
25975961	25975984	21	+	27260156	A375	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.8109559325551906	[158]	[279,308,501,220]	9	hSpCas9	negative selection	5835509
25975084	25975107	21	-	27260156	COLO741	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.28404499962992413	[1456]	[2334,2244,2223]	6	hSpCas9	negative selection	5892474
25982420	25982443	21	-	27260156	COLO741	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.0420460868212308	[442]	[470,640,530]	-1	hSpCas9	negative selection	5892475
25982425	25982448	21	+	27260156	COLO741	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.335448679606525	[551]	[886,966,818]	7	hSpCas9	negative selection	5892476
25975114	25975137	21	-	27260156	COLO741	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.4236831484485333	[139]	[304,281,144]	8	hSpCas9	negative selection	5956758
25975965	25975988	21	-	27260156	COLO741	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.4829901475365672	[164]	[80,180,181]	-8	hSpCas9	negative selection	5956759
25975961	25975984	21	+	27260156	COLO741	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.5155449529601093	[158]	[211,178,459]	8	hSpCas9	negative selection	5956760
25975084	25975107	21	-	27260156	CAL120	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.32697044188465996	[1456]	[3301,1874,1807]	5	hSpCas9	negative selection	6013725
25982420	25982443	21	-	27260156	CAL120	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.30090414448085145	[442]	[513,598,242]	-4	hSpCas9	negative selection	6013726
25982425	25982448	21	+	27260156	CAL120	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.3444573498453136	[551]	[975,856,799]	5	hSpCas9	negative selection	6013727
25975114	25975137	21	-	27260156	CAL120	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.4534814538255838	[139]	[217,172,319]	6	hSpCas9	negative selection	6078009
25975965	25975988	21	-	27260156	CAL120	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.11684266829496659	[164]	[227,69,367]	1	hSpCas9	negative selection	6078010
25975961	25975984	21	+	27260156	CAL120	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.7172125628397822	[158]	[439,173,377]	9	hSpCas9	negative selection	6078011
25975084	25975107	21	-	27260156	CADOES1	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.14641104635338364	[1456]	[1630,1752,1258,1350]	2	hSpCas9	negative selection	6134976
25982420	25982443	21	-	27260156	CADOES1	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.11916545689323861	[442]	[543,425,389,428]	2	hSpCas9	negative selection	6134977
25982425	25982448	21	+	27260156	CADOES1	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.12227471817705599	[551]	[556,397,665,615]	2	hSpCas9	negative selection	6134978
25975114	25975137	21	-	27260156	CADOES1	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.44417985513592506	[139]	[147,210,140,209]	7	hSpCas9	negative selection	6199260
25975965	25975988	21	-	27260156	CADOES1	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.45298005791140916	[164]	[122,94,152,75]	-7	hSpCas9	negative selection	6199261
25975961	25975984	21	+	27260156	CADOES1	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.15378655636277627	[158]	[148,158,212,135]	2	hSpCas9	negative selection	6199262
25975084	25975107	21	-	27260156	EWS502	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.2918732899959151	[1456]	[1692,1584,2158,2172]	5	hSpCas9	negative selection	6256227
25982420	25982443	21	-	27260156	EWS502	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.37459925825091417	[442]	[742,481,769,412]	6	hSpCas9	negative selection	6256228
25982425	25982448	21	+	27260156	EWS502	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.3168293880509947	[551]	[585,638,701,1024]	5	hSpCas9	negative selection	6256229
25975114	25975137	21	-	27260156	EWS502	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.5999851800257296	[139]	[208,183,357,146]	9	hSpCas9	negative selection	6320511
25975965	25975988	21	-	27260156	EWS502	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.46897681205619124	[164]	[294,210,181,274]	7	hSpCas9	negative selection	6320512
25975961	25975984	21	+	27260156	EWS502	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.40443050150818527	[158]	[313,123,169,278]	7	hSpCas9	negative selection	6320513
25975084	25975107	21	-	27260156	EW8	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.029946779756437003	[1456]	[1366,1447,1005,1050]	0	hSpCas9	negative selection	6377478
25982420	25982443	21	-	27260156	EW8	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.10934458856068989	[442]	[472,444,273,384]	2	hSpCas9	negative selection	6377479
25982425	25982448	21	+	27260156	EW8	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.40243080700168365	[551]	[737,635,472,552]	7	hSpCas9	negative selection	6377480
25975114	25975137	21	-	27260156	EW8	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.3333515909519358	[139]	[296,129,74,97]	6	hSpCas9	negative selection	6441762
25975965	25975988	21	-	27260156	EW8	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.048043733162083324	[164]	[191,134,129,102]	0	hSpCas9	negative selection	6441763
25975961	25975984	21	+	27260156	EW8	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.18348143783044302	[158]	[122,104,211,130]	3	hSpCas9	negative selection	6441764
25975084	25975107	21	-	27260156	CORL105	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.4110961681586318	[1456]	[2195,1921,2905,2151]	7	hSpCas9	negative selection	6498729
25982420	25982443	21	-	27260156	CORL105	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.19029416387214354	[442]	[791,497,529,545]	3	hSpCas9	negative selection	6498730
25982425	25982448	21	+	27260156	CORL105	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.4957965571682137	[551]	[856,824,1155,844]	8	hSpCas9	negative selection	6498731
25975114	25975137	21	-	27260156	CORL105	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.670000079798933	[139]	[366,215,255,207]	9	hSpCas9	negative selection	6563013
25975965	25975988	21	-	27260156	CORL105	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.3667594307788413	[164]	[145,172,126,148]	-6	hSpCas9	negative selection	6563014
25975961	25975984	21	+	27260156	CORL105	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	-0.21350779328795433	[158]	[130,181,262,80]	-4	hSpCas9	negative selection	6563015
25975084	25975107	21	-	27260156	HS294T	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.46657307759072064	[1456]	[863,582,851,816]	6	hSpCas9	negative selection	6619980
25982420	25982443	21	-	27260156	HS294T	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.6606407141000842	[442]	[455,167,170,272]	8	hSpCas9	negative selection	6619981
25982425	25982448	21	+	27260156	HS294T	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.31517871496568317	[551]	[275,284,225,273]	4	hSpCas9	negative selection	6619982
25975114	25975137	21	-	27260156	HS294T	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.2570932255436009	[139]	[44,69,71,74]	3	hSpCas9	negative selection	6684264
25975965	25975988	21	-	27260156	HS294T	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.16083438458020272	[164]	[57,65,64,34]	-2	hSpCas9	negative selection	6684265
25975961	25975984	21	+	27260156	HS294T	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.4313851638656667	[158]	[71,65,116,76]	6	hSpCas9	negative selection	6684266
25975084	25975107	21	-	27260156	HCC44	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.11963577238314249	[1456]	[2461,1355,2105,1412]	2	hSpCas9	negative selection	6741231
25982420	25982443	21	-	27260156	HCC44	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.20564955342654356	[442]	[472,355,507,424]	-3	hSpCas9	negative selection	6741232
25982425	25982448	21	+	27260156	HCC44	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.07541477042106914	[551]	[671,601,699,667]	1	hSpCas9	negative selection	6741233
25975114	25975137	21	-	27260156	HCC44	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.3486234954626082	[139]	[164,199,338,123]	5	hSpCas9	negative selection	6805515
25975965	25975988	21	-	27260156	HCC44	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.23781502245678032	[164]	[218,253,115,264]	4	hSpCas9	negative selection	6805516
25975961	25975984	21	+	27260156	HCC44	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.45445624696469844	[158]	[314,208,301,180]	7	hSpCas9	negative selection	6805517
25975084	25975107	21	-	27260156	G402	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.3655417816466602	[1456]	[2170,2278,2475,2212]	4	hSpCas9	negative selection	6862482
25982420	25982443	21	-	27260156	G402	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.29327525897928874	[442]	[499,434,269,559]	-4	hSpCas9	negative selection	6862483
25982425	25982448	21	+	27260156	G402	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.43601614906631514	[551]	[1090,612,674,1253]	5	hSpCas9	negative selection	6862484
25975114	25975137	21	-	27260156	G402	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.42241343874494386	[139]	[164,232,196,306]	5	hSpCas9	negative selection	6926766
25975965	25975988	21	-	27260156	G402	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.24433682081073282	[164]	[196,300,70,123]	-3	hSpCas9	negative selection	6926767
25975961	25975984	21	+	27260156	G402	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.2128522389652172	[158]	[304,87,195,308]	2	hSpCas9	negative selection	6926768
25975084	25975107	21	-	27260156	L33	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.3106565926427767	[1456]	[1885,689,1155,1816]	6	hSpCas9	negative selection	6983733
25982420	25982443	21	-	27260156	L33	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.34373462675884214	[442]	[505,264,424,422]	7	hSpCas9	negative selection	6983734
25982425	25982448	21	+	27260156	L33	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	-0.007509936894827096	[551]	[434,254,317,634]	0	hSpCas9	negative selection	6983735
25975114	25975137	21	-	27260156	L33	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.2112065016912068	[139]	[173,54,91,192]	4	hSpCas9	negative selection	7048017
25975965	25975988	21	-	27260156	L33	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.5213755848513351	[164]	[83,42,81,140]	-8	hSpCas9	negative selection	7048018
25975961	25975984	21	+	27260156	L33	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	-0.14891578257422777	[158]	[118,54,125,120]	-3	hSpCas9	negative selection	7048019
25975084	25975107	21	-	27260156	K562	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.4241369597905369	[1456]	[1518,2305,1936,1240]	5	hSpCas9	negative selection	7104984
25982420	25982443	21	-	27260156	K562	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.3502585922144464	[442]	[740,376,635,286]	4	hSpCas9	negative selection	7104985
25982425	25982448	21	+	27260156	K562	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.06722388276013325	[551]	[885,580,332,308]	0	hSpCas9	negative selection	7104986
25975114	25975137	21	-	27260156	K562	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.4374494542491185	[139]	[163,103,179,214]	5	hSpCas9	negative selection	7169268
25975965	25975988	21	-	27260156	K562	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.5998722813768951	[164]	[223,192,223,241]	7	hSpCas9	negative selection	7169269
25975961	25975984	21	+	27260156	K562	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.16437291444471747	[158]	[167,132,253,84]	2	hSpCas9	negative selection	7169270
25975084	25975107	21	-	27260156	HT29	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.18722119626759892	[1456]	[2266,2328,2008,1550]	3	hSpCas9	negative selection	7226235
25982420	25982443	21	-	27260156	HT29	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.2471077016184684	[442]	[732,865,604,403]	5	hSpCas9	negative selection	7226236
25982425	25982448	21	+	27260156	HT29	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.3170607373213955	[551]	[1078,868,752,677]	6	hSpCas9	negative selection	7226237
25975114	25975137	21	-	27260156	HT29	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	-0.35626520770268844	[139]	[163,141,166,68]	-6	hSpCas9	negative selection	7290519
25975965	25975988	21	-	27260156	HT29	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.09203246109102947	[164]	[176,241,146,188]	-2	hSpCas9	negative selection	7290520
25975961	25975984	21	+	27260156	HT29	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.22143444759786646	[158]	[283,174,287,160]	4	hSpCas9	negative selection	7290521
25975084	25975107	21	-	27260156	MHHES1	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.2622950343110788	[1456]	[2226,2223,1969,1559]	5	hSpCas9	negative selection	7347486
25982420	25982443	21	-	27260156	MHHES1	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.12998984871237862	[442]	[659,604,566,394]	2	hSpCas9	negative selection	7347487
25982425	25982448	21	+	27260156	MHHES1	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	-0.05369935143424373	[551]	[830,733,477,421]	-1	hSpCas9	negative selection	7347488
25975114	25975137	21	-	27260156	MHHES1	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.5017456769325102	[139]	[150,243,265,220]	8	hSpCas9	negative selection	7411770
25975965	25975988	21	-	27260156	MHHES1	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.1388520961761528	[164]	[180,294,110,226]	2	hSpCas9	negative selection	7411771
25975961	25975984	21	+	27260156	MHHES1	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.33161866504053616	[158]	[165,361,202,181]	6	hSpCas9	negative selection	7411772
25975084	25975107	21	-	27260156	MEWO	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.12566530937033504	[1456]	[1856,1247,1428]	3	hSpCas9	negative selection	7468737
25982420	25982443	21	-	27260156	MEWO	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.03546826293017265	[442]	[363,455,384]	0	hSpCas9	negative selection	7468738
25982425	25982448	21	+	27260156	MEWO	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.36107916157151076	[551]	[719,606,673]	7	hSpCas9	negative selection	7468739
25975114	25975137	21	-	27260156	MEWO	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.4683632723759785	[139]	[131,194,206]	8	hSpCas9	negative selection	7533021
25975965	25975988	21	-	27260156	MEWO	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.5279861430838666	[164]	[75,133,104]	-8	hSpCas9	negative selection	7533022
25975961	25975984	21	+	27260156	MEWO	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	-0.1421070929699928	[158]	[158,146,102]	-3	hSpCas9	negative selection	7533023
25975084	25975107	21	-	27260156	LNCAPCLONEFGC	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.075567683776951	[1456]	[1191,1358,1651,1403]	1	hSpCas9	negative selection	7589988
25982420	25982443	21	-	27260156	LNCAPCLONEFGC	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.03652032227243042	[442]	[404,321,511,427]	0	hSpCas9	negative selection	7589989
25982425	25982448	21	+	27260156	LNCAPCLONEFGC	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.3758534034244809	[551]	[566,473,937,671]	6	hSpCas9	negative selection	7589990
25975114	25975137	21	-	27260156	LNCAPCLONEFGC	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.6679034913035511	[139]	[202,146,299,173]	9	hSpCas9	negative selection	7654272
25975965	25975988	21	-	27260156	LNCAPCLONEFGC	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.45737368009031565	[164]	[149,245,109,298]	7	hSpCas9	negative selection	7654273
25975961	25975984	21	+	27260156	LNCAPCLONEFGC	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.027504883143834702	[158]	[148,183,108,136]	0	hSpCas9	negative selection	7654274
25975084	25975107	21	-	27260156	PANC0327	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.19814983631732308	[1456]	[1533,1277,1308,1847]	3	hSpCas9	negative selection	7711239
25982420	25982443	21	-	27260156	PANC0327	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.4289792504289325	[442]	[926,439,388,406]	6	hSpCas9	negative selection	7711240
25982425	25982448	21	+	27260156	PANC0327	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.2376866331022497	[551]	[701,491,669,469]	3	hSpCas9	negative selection	7711241
25975114	25975137	21	-	27260156	PANC0327	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	1.3765639100393245	[139]	[242,328,258,452]	9	hSpCas9	negative selection	7775523
25975965	25975988	21	-	27260156	PANC0327	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.41412663053011967	[164]	[152,177,243,204]	6	hSpCas9	negative selection	7775524
25975961	25975984	21	+	27260156	PANC0327	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.22183456570740967	[158]	[190,279,81,92]	3	hSpCas9	negative selection	7775525
25975084	25975107	21	-	27260156	NCIH2009	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.5299469713404059	[1456]	[2814,2782,3192]	7	hSpCas9	negative selection	7832490
25982420	25982443	21	-	27260156	NCIH2009	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.5113479026984281	[442]	[1365,650,727]	7	hSpCas9	negative selection	7832491
25982425	25982448	21	+	27260156	NCIH2009	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.35250330597718826	[551]	[1250,820,935]	5	hSpCas9	negative selection	7832492
25975114	25975137	21	-	27260156	NCIH2009	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.1824749043586662	[139]	[278,211,185]	2	hSpCas9	negative selection	7896774
25975965	25975988	21	-	27260156	NCIH2009	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.20309748181843812	[164]	[217,172,396]	2	hSpCas9	negative selection	7896775
25975961	25975984	21	+	27260156	NCIH2009	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	-0.21436037505602656	[158]	[267,203,116]	-3	hSpCas9	negative selection	7896776
25975084	25975107	21	-	27260156	NCIH1373	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.4816314985721941	[1456]	[2461,2183,2709,459]	5	hSpCas9	negative selection	7953741
25982420	25982443	21	-	27260156	NCIH1373	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.5488003403763752	[442]	[596,335,1007,260]	5	hSpCas9	negative selection	7953742
25982425	25982448	21	+	27260156	NCIH1373	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.16103253171021215	[551]	[890,662,721,133]	1	hSpCas9	negative selection	7953743
25975114	25975137	21	-	27260156	NCIH1373	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	1.0005241663264746	[139]	[691,158,134,91]	8	hSpCas9	negative selection	8018025
25975965	25975988	21	-	27260156	NCIH1373	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.6758234467731052	[164]	[91,92,125,39]	-6	hSpCas9	negative selection	8018026
25975961	25975984	21	+	27260156	NCIH1373	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.18626480805214252	[158]	[254,107,216,65]	1	hSpCas9	negative selection	8018027
25975084	25975107	21	-	27260156	PATU8902	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.19999202252360515	[1456]	[2256,2816,1931,2414]	2	hSpCas9	negative selection	8074992
25982420	25982443	21	-	27260156	PATU8902	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.5878401028648398	[442]	[964,840,1078,755]	6	hSpCas9	negative selection	8074993
25982425	25982448	21	+	27260156	PATU8902	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.3331769226259479	[551]	[1299,1112,573,978]	3	hSpCas9	negative selection	8074994
25975114	25975137	21	-	27260156	PATU8902	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.7260674982915729	[139]	[170,349,269,537]	7	hSpCas9	negative selection	8139276
25975965	25975988	21	-	27260156	PATU8902	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.30383016939807117	[164]	[328,93,77,737]	3	hSpCas9	negative selection	8139277
25975961	25975984	21	+	27260156	PATU8902	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.07729464382276285	[158]	[270,346,174,143]	0	hSpCas9	negative selection	8139278
25975084	25975107	21	-	27260156	PANC1	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	-0.0028062179590138125	[1456]	[1278,1727,1215,906]	0	hSpCas9	negative selection	8196243
25982420	25982443	21	-	27260156	PANC1	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.011425828972127183	[442]	[319,539,431,285]	0	hSpCas9	negative selection	8196244
25982425	25982448	21	+	27260156	PANC1	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	-0.019332869419445897	[551]	[604,497,326,439]	0	hSpCas9	negative selection	8196245
25975114	25975137	21	-	27260156	PANC1	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.2707545710766124	[139]	[131,88,226,122]	4	hSpCas9	negative selection	8260527
25975965	25975988	21	-	27260156	PANC1	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.16538190923617746	[164]	[116,85,234,67]	-3	hSpCas9	negative selection	8260528
25975961	25975984	21	+	27260156	PANC1	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.4232290971041086	[158]	[206,196,134,190]	7	hSpCas9	negative selection	8260529
25975084	25975107	21	-	27260156	PANC0813	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.3327502858790161	[1456]	[1945,2142,1896,2586]	5	hSpCas9	negative selection	8317494
25982420	25982443	21	-	27260156	PANC0813	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.18446279169833568	[442]	[629,547,769,429]	3	hSpCas9	negative selection	8317495
25982425	25982448	21	+	27260156	PANC0813	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	-0.10648475518114126	[551]	[765,647,607,411]	-2	hSpCas9	negative selection	8317496
25975114	25975137	21	-	27260156	PANC0813	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.16708153304687134	[139]	[166,111,305,153]	2	hSpCas9	negative selection	8381778
25975965	25975988	21	-	27260156	PANC0813	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	0.19673760174332733	[164]	[141,272,280,186]	3	hSpCas9	negative selection	8381779
25975961	25975984	21	+	27260156	PANC0813	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.41758821633326537	[158]	[255,227,330,186]	6	hSpCas9	negative selection	8381780
25975084	25975107	21	-	27260156	RDES	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.2743728145408433	[1456]	[1717,1918,1915,2659]	4	hSpCas9	negative selection	8438745
25982420	25982443	21	-	27260156	RDES	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.1397499876665373	[442]	[350,451,515,558]	-2	hSpCas9	negative selection	8438746
25982425	25982448	21	+	27260156	RDES	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.20152861004736844	[551]	[551,669,929,810]	3	hSpCas9	negative selection	8438747
25975114	25975137	21	-	27260156	RDES	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.7108407937323606	[139]	[242,215,256,351]	9	hSpCas9	negative selection	8503029
25975965	25975988	21	-	27260156	RDES	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.4599808154651108	[164]	[126,121,115,193]	-7	hSpCas9	negative selection	8503030
25975961	25975984	21	+	27260156	RDES	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.2675776167085233	[158]	[186,313,140,226]	4	hSpCas9	negative selection	8503031
25975084	25975107	21	-	27260156	PC3	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.20381284729814753	[1456]	[988,1497,3146,1792]	4	hSpCas9	negative selection	8559996
25982420	25982443	21	-	27260156	PC3	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	-0.25517281289414745	[442]	[205,417,590,387]	-5	hSpCas9	negative selection	8559997
25982425	25982448	21	+	27260156	PC3	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.06090964513657643	[551]	[431,571,907,506]	1	hSpCas9	negative selection	8559998
25975114	25975137	21	-	27260156	PC3	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.6844001528837693	[139]	[132,268,331,220]	9	hSpCas9	negative selection	8624280
25975965	25975988	21	-	27260156	PC3	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.21960014205726552	[164]	[124,157,156,116]	-5	hSpCas9	negative selection	8624281
25975961	25975984	21	+	27260156	PC3	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.029591455027916158	[158]	[112,134,270,176]	0	hSpCas9	negative selection	8624282
25975084	25975107	21	-	27260156	PATU8988T	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.2863986281503146	[1456]	[1931,1643,1854,1402]	5	hSpCas9	negative selection	8681247
25982420	25982443	21	-	27260156	PATU8988T	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.07527206598631521	[442]	[388,434,568,403]	1	hSpCas9	negative selection	8681248
25982425	25982448	21	+	27260156	PATU8988T	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.5187868174547012	[551]	[1097,560,731,636]	8	hSpCas9	negative selection	8681249
25975114	25975137	21	-	27260156	PATU8988T	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.6231353365301446	[139]	[156,126,312,228]	8	hSpCas9	negative selection	8745531
25975965	25975988	21	-	27260156	PATU8988T	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.3754622939177368	[164]	[63,135,170,120]	-6	hSpCas9	negative selection	8745532
25975961	25975984	21	+	27260156	PATU8988T	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.6415290199081791	[158]	[349,334,155,117]	9	hSpCas9	negative selection	8745533
25975084	25975107	21	-	27260156	T47D	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.159404266348677	[1456]	[1997,1723,1920,1955]	3	hSpCas9	negative selection	8802498
25982420	25982443	21	-	27260156	T47D	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.050227916611921414	[442]	[598,547,407,584]	1	hSpCas9	negative selection	8802499
25982425	25982448	21	+	27260156	T47D	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.3574615622721904	[551]	[879,767,813,838]	7	hSpCas9	negative selection	8802500
25975114	25975137	21	-	27260156	T47D	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.5101284718779073	[139]	[232,213,257,224]	9	hSpCas9	negative selection	8866782
25975965	25975988	21	-	27260156	T47D	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.14023428081619982	[164]	[184,157,180,174]	-3	hSpCas9	negative selection	8866783
25975961	25975984	21	+	27260156	T47D	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.13870520176686685	[158]	[169,183,204,259]	3	hSpCas9	negative selection	8866784
25975084	25975107	21	-	27260156	SU8686	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.31985158253689283	[1456]	[1670,1625,1750,2261]	5	hSpCas9	negative selection	8923749
25982420	25982443	21	-	27260156	SU8686	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.4686039784676874	[442]	[461,412,731,914]	7	hSpCas9	negative selection	8923750
25982425	25982448	21	+	27260156	SU8686	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.5761560431134478	[551]	[847,783,646,1004]	8	hSpCas9	negative selection	8923751
25975114	25975137	21	-	27260156	SU8686	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.3893883107955831	[139]	[173,166,183,207]	6	hSpCas9	negative selection	8988033
25975965	25975988	21	-	27260156	SU8686	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.20358986218244857	[164]	[77,78,130,323]	-4	hSpCas9	negative selection	8988034
25975961	25975984	21	+	27260156	SU8686	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.2599078695561827	[158]	[201,161,171,224]	4	hSpCas9	negative selection	8988035
25975084	25975107	21	-	27260156	SKES1	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.03778793860873275	[1456]	[1845,1415,1341,1400]	0	hSpCas9	negative selection	9045000
25982420	25982443	21	-	27260156	SKES1	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.22655638242942028	[442]	[593,674,504,339]	5	hSpCas9	negative selection	9045001
25982425	25982448	21	+	27260156	SKES1	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.09274960319582842	[551]	[707,754,395,529]	2	hSpCas9	negative selection	9045002
25975114	25975137	21	-	27260156	SKES1	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.46331700451375846	[139]	[268,206,200,112]	8	hSpCas9	negative selection	9109284
25975965	25975988	21	-	27260156	SKES1	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.4594773666097094	[164]	[52,129,208,80]	-7	hSpCas9	negative selection	9109285
25975961	25975984	21	+	27260156	SKES1	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.3855834683367432	[158]	[218,213,185,209]	7	hSpCas9	negative selection	9109286
25975084	25975107	21	-	27260156	TOV112D	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.010978005941037816	[1456]	[1767,1797,1460,971]	0	hSpCas9	negative selection	9166251
25982420	25982443	21	-	27260156	TOV112D	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.037689008419068915	[442]	[465,492,412,458]	0	hSpCas9	negative selection	9166252
25982425	25982448	21	+	27260156	TOV112D	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.1533653763072853	[551]	[576,728,513,661]	3	hSpCas9	negative selection	9166253
25975114	25975137	21	-	27260156	TOV112D	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.6392396492604255	[139]	[323,205,237,113]	9	hSpCas9	negative selection	9230535
25975965	25975988	21	-	27260156	TOV112D	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.29646824005284245	[164]	[155,196,60,140]	-5	hSpCas9	negative selection	9230536
25975961	25975984	21	+	27260156	TOV112D	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.0021193311351785926	[158]	[247,68,151,153]	0	hSpCas9	negative selection	9230537
25975084	25975107	21	-	27260156	TC71	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.16901495078226692	[1456]	[1744,1741,1690,1853]	4	hSpCas9	negative selection	9287502
25982420	25982443	21	-	27260156	TC71	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.14023670201801744	[442]	[517,577,465,533]	3	hSpCas9	negative selection	9287503
25982425	25982448	21	+	27260156	TC71	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.2599729729224293	[551]	[551,613,840,833]	6	hSpCas9	negative selection	9287504
25975114	25975137	21	-	27260156	TC71	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.2297718034758751	[139]	[174,140,158,232]	5	hSpCas9	negative selection	9351786
25975965	25975988	21	-	27260156	TC71	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.37530230755385596	[164]	[74,174,139,157]	-8	hSpCas9	negative selection	9351787
25975961	25975984	21	+	27260156	TC71	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	0.2690408417599124	[158]	[186,189,186,261]	6	hSpCas9	negative selection	9351788
25975084	25975107	21	-	27260156	TC32	viability	GAACTACATCACCGCTCTGCAGG	APP	ENSG00000142192	0.17408045559621632	[1456]	[1606,1031,2013,1711]	3	hSpCas9	negative selection	9408753
25982420	25982443	21	-	27260156	TC32	viability	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.1344337723275792	[442]	[517,414,352,503]	2	hSpCas9	negative selection	9408754
25982425	25982448	21	+	27260156	TC32	viability	TGTCTCGAGATACTTGTCAACGG	APP	ENSG00000142192	0.13198527907264174	[551]	[528,368,889,590]	2	hSpCas9	negative selection	9408755
25975114	25975137	21	-	27260156	TC32	viability	GCTCAATGACCGCCGCCGCCTGG	APP	ENSG00000142192	0.3050459807116579	[139]	[114,48,242,306]	5	hSpCas9	negative selection	9473037
25975965	25975988	21	-	27260156	TC32	viability	CTTGCCTAAAGCTGATAAGAAGG	APP	ENSG00000142192	-0.07579850832431023	[164]	[159,169,81,143]	-1	hSpCas9	negative selection	9473038
25975961	25975984	21	+	27260156	TC32	viability	ACTGCCTTCTTATCAGCTTTAGG	APP	ENSG00000142192	-0.04735214262135812	[158]	[108,71,304,144]	-1	hSpCas9	negative selection	9473039
25982420	25982443	21	-	27869803	HPAFII	viability after 27 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.8361888554800806	[233]	[55,355,NaN]	6	hSpCas9	negative selection	9578925
26000064	26000087	21	-	27869803	HPAFII	viability after 27 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	-0.87023787565275	[561]	[117,197,NaN]	-6	hSpCas9	negative selection	9578926
26051119	26051142	21	-	27869803	HPAFII	viability after 27 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	0.3171228469977494	[204]	[160,111,NaN]	2	hSpCas9	negative selection	9578927
26053305	26053328	21	+	27869803	HPAFII	viability after 27 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.19137781609070348	[400]	[201,272,NaN]	1	hSpCas9	negative selection	9578928
26089996	26090019	21	-	27869803	HPAFII	viability after 27 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	0.34918930592902786	[457]	[201,393,NaN]	3	hSpCas9	negative selection	9578929
25982420	25982443	21	-	27869803	HPAFII	viability after 15 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.14228967526718617	[233]	[152,354,NaN]	1	hSpCas9	negative selection	9661374
26000064	26000087	21	-	27869803	HPAFII	viability after 15 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	-0.22456256386548534	[561]	[704,399,NaN]	-3	hSpCas9	negative selection	9661375
26051119	26051142	21	-	27869803	HPAFII	viability after 15 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	0.43693676381453966	[204]	[325,280,NaN]	5	hSpCas9	negative selection	9661376
26053305	26053328	21	+	27869803	HPAFII	viability after 15 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.3066068341058601	[400]	[717,417,NaN]	3	hSpCas9	negative selection	9661377
26089996	26090019	21	-	27869803	HPAFII	viability after 15 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	0.27061314339766485	[457]	[586,597,NaN]	3	hSpCas9	negative selection	9661378
25982420	25982443	21	-	27869803	ASPC1	viability after 36 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.043588713141753166	[737]	[272,347,191]	0	hSpCas9	negative selection	9743823
26000064	26000087	21	-	27869803	ASPC1	viability after 36 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	0.9636485130682073	[1397]	[1098,1052,757]	8	hSpCas9	negative selection	9743824
26051119	26051142	21	-	27869803	ASPC1	viability after 36 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	0.9165473259183395	[198]	[418,19,15]	8	hSpCas9	negative selection	9743825
26053305	26053328	21	+	27869803	ASPC1	viability after 36 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.07395660714251767	[860]	[223,426,289]	0	hSpCas9	negative selection	9743826
26089996	26090019	21	-	27869803	ASPC1	viability after 36 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	0.2641491208080413	[1045]	[714,421,252]	2	hSpCas9	negative selection	9743827
25982420	25982443	21	-	27869803	PATU8988S	viability after 35 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.44532957932090345	[533]	[223,361,NaN]	5	hSpCas9	negative selection	9826272
26000064	26000087	21	-	27869803	PATU8988S	viability after 35 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	-0.4535977339596692	[1099]	[325,320,NaN]	-5	hSpCas9	negative selection	9826273
26051119	26051142	21	-	27869803	PATU8988S	viability after 35 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	1.429088645231202	[277]	[298,303,NaN]	9	hSpCas9	negative selection	9826274
26053305	26053328	21	+	27869803	PATU8988S	viability after 35 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.04042795322006093	[749]	[374,245,NaN]	0	hSpCas9	negative selection	9826275
26089996	26090019	21	-	27869803	PATU8988S	viability after 35 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.07068383707049442	[1119]	[653,203,NaN]	0	hSpCas9	negative selection	9826276
25982420	25982443	21	-	27869803	PATU8988S	viability after 31 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.3442458439784832	[533]	[224,327,NaN]	4	hSpCas9	negative selection	9908721
26000064	26000087	21	-	27869803	PATU8988S	viability after 31 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	-0.42956836571478885	[1099]	[260,407,NaN]	-5	hSpCas9	negative selection	9908722
26051119	26051142	21	-	27869803	PATU8988S	viability after 31 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	0.9449976715291802	[277]	[252,162,NaN]	9	hSpCas9	negative selection	9908723
26053305	26053328	21	+	27869803	PATU8988S	viability after 31 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	-0.05752726402583003	[749]	[322,241,NaN]	0	hSpCas9	negative selection	9908724
26089996	26090019	21	-	27869803	PATU8988S	viability after 31 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	-0.21328569040663647	[1119]	[470,275,NaN]	-2	hSpCas9	negative selection	9908725
25982420	25982443	21	-	27869803	HPAFII	viability after 35 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.7889211871245966	[233]	[24,406,NaN]	5	hSpCas9	negative selection	9991170
26000064	26000087	21	-	27869803	HPAFII	viability after 35 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	-0.9380378463894278	[561]	[84,219,NaN]	-5	hSpCas9	negative selection	9991171
26051119	26051142	21	-	27869803	HPAFII	viability after 35 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	0.46956041872316684	[204]	[138,148,NaN]	3	hSpCas9	negative selection	9991172
26053305	26053328	21	+	27869803	HPAFII	viability after 35 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.5995269889757772	[400]	[205,421,NaN]	4	hSpCas9	negative selection	9991173
26089996	26090019	21	-	27869803	HPAFII	viability after 35 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	0.43953804129274965	[457]	[138,511,NaN]	3	hSpCas9	negative selection	9991174
25982420	25982443	21	-	27869803	HPAFII	viability after 31 days	GACAAGTATCTCGAGACACCTGG	APP	ENSG00000142192	0.6067080871165444	[233]	[31,382,NaN]	4	hSpCas9	negative selection	10073619
26000064	26000087	21	-	27869803	HPAFII	viability after 31 days	ACGGCGGATGTGGCGGCAACCGG	APP	ENSG00000142192	-1.0595826292393822	[561]	[57,252,NaN]	-6	hSpCas9	negative selection	10073620
26051119	26051142	21	-	27869803	HPAFII	viability after 31 days	GCGGAATTGACAAGTTCCGAGGG	APP	ENSG00000142192	0.0836990022588242	[204]	[108,135,NaN]	0	hSpCas9	negative selection	10073621
26053305	26053328	21	+	27869803	HPAFII	viability after 31 days	GCACTTGTCAGGAACGAGAAGGG	APP	ENSG00000142192	0.48426997226971	[400]	[198,440,NaN]	3	hSpCas9	negative selection	10073622
26089996	26090019	21	-	27869803	HPAFII	viability after 31 days	ATCCAGAACTGGTGCAAGCGGGG	APP	ENSG00000142192	0.14873239403254246	[457]	[93,492,NaN]	1	hSpCas9	negative selection	10073623
26089931	26089954	21	+	28162770	P31FUJ	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.17189335064300604	[419]	[555]	1	hSpCas9	negative selection	10112369
25911770	25911793	21	+	28162770	P31FUJ	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	-0.08585233869561393	[428]	[474]	-1	hSpCas9	negative selection	10112370
25911740	25911763	21	-	28162770	P31FUJ	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	-0.9697677985805848	[9]	[5]	-6	hSpCas9	negative selection	10112371
26053284	26053307	21	-	28162770	P31FUJ	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	0.14511583930376548	[373]	[485]	1	hSpCas9	negative selection	10112372
26022014	26022037	21	-	28162770	P31FUJ	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	0.5612131307707862	[356]	[618]	6	hSpCas9	negative selection	10112373
25975056	25975079	21	+	28162770	P31FUJ	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-0.31187377540557737	[74]	[70]	-3	hSpCas9	negative selection	10112374
25954656	25954679	21	+	28162770	P31FUJ	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	0.28592659790669084	[103]	[148]	3	hSpCas9	negative selection	10112375
25954614	25954637	21	-	28162770	P31FUJ	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	0.24026741623588022	[66]	[92]	2	hSpCas9	negative selection	10112376
25911837	25911860	21	-	28162770	P31FUJ	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	0.24524509239026582	[27]	[38]	2	hSpCas9	negative selection	10112377
25911823	25911846	21	+	28162770	P31FUJ	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	-1.5088144642463823	[200]	[82]	-7	hSpCas9	negative selection	10112378
26089931	26089954	21	+	28162770	TF1	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	NaN	[NaN]	[317]	1	hSpCas9	negative selection	10281735
25911770	25911793	21	+	28162770	TF1	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	NaN	[NaN]	[379]	1	hSpCas9	negative selection	10281736
25911740	25911763	21	-	28162770	TF1	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	NaN	[NaN]	[3]	1	hSpCas9	negative selection	10281737
26053284	26053307	21	-	28162770	TF1	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	NaN	[NaN]	[302]	1	hSpCas9	negative selection	10281738
26022014	26022037	21	-	28162770	TF1	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	NaN	[NaN]	[409]	1	hSpCas9	negative selection	10281739
25975056	25975079	21	+	28162770	TF1	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	NaN	[NaN]	[33]	1	hSpCas9	negative selection	10281740
25954656	25954679	21	+	28162770	TF1	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	NaN	[NaN]	[95]	1	hSpCas9	negative selection	10281741
25954614	25954637	21	-	28162770	TF1	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	NaN	[NaN]	[45]	1	hSpCas9	negative selection	10281742
25911837	25911860	21	-	28162770	TF1	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	NaN	[NaN]	[75]	1	hSpCas9	negative selection	10281743
25911823	25911846	21	+	28162770	TF1	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	NaN	[NaN]	[121]	1	hSpCas9	negative selection	10281744
26089931	26089954	21	+	28162770	SKM1	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.005418847089704304	[101]	[180]	0	hSpCas9	negative selection	10451101
25911770	25911793	21	+	28162770	SKM1	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	-0.04558495313707578	[100]	[172]	0	hSpCas9	negative selection	10451102
25911740	25911763	21	-	28162770	SKM1	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	1.5930358012568382	[2]	[15]	9	hSpCas9	negative selection	10451103
26053284	26053307	21	-	28162770	SKM1	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	0.5946450541184956	[111]	[298]	6	hSpCas9	negative selection	10451104
26022014	26022037	21	-	28162770	SKM1	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	0.36882064431357264	[98]	[225]	3	hSpCas9	negative selection	10451105
25975056	25975079	21	+	28162770	SKM1	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-1.4918530963296748	[34]	[21]	-7	hSpCas9	negative selection	10451106
25954656	25954679	21	+	28162770	SKM1	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	1.5378942470643775	[14]	[76]	9	hSpCas9	negative selection	10451107
25954614	25954637	21	-	28162770	SKM1	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	0.8884916847830095	[10]	[35]	8	hSpCas9	negative selection	10451108
25911837	25911860	21	-	28162770	SKM1	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	-0.6699986045769557	[8]	[9]	-5	hSpCas9	negative selection	10451109
25911823	25911846	21	+	28162770	SKM1	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	0.09310940439148141	[34]	[65]	0	hSpCas9	negative selection	10451110
26089931	26089954	21	+	28162770	SKM1	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.005418847089704304	[101]	[180]	0	hSpCas9	negative selection	10620467
25911770	25911793	21	+	28162770	SKM1	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	-0.04558495313707578	[100]	[172]	0	hSpCas9	negative selection	10620468
25911740	25911763	21	-	28162770	SKM1	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	1.5930358012568382	[2]	[15]	9	hSpCas9	negative selection	10620469
26053284	26053307	21	-	28162770	SKM1	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	0.5946450541184956	[111]	[298]	6	hSpCas9	negative selection	10620470
26022014	26022037	21	-	28162770	SKM1	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	0.36882064431357264	[98]	[225]	3	hSpCas9	negative selection	10620471
25975056	25975079	21	+	28162770	SKM1	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-1.4918530963296748	[34]	[21]	-7	hSpCas9	negative selection	10620472
25954656	25954679	21	+	28162770	SKM1	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	1.5378942470643775	[14]	[76]	9	hSpCas9	negative selection	10620473
25954614	25954637	21	-	28162770	SKM1	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	0.8884916847830095	[10]	[35]	8	hSpCas9	negative selection	10620474
25911837	25911860	21	-	28162770	SKM1	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	-0.6699986045769557	[8]	[9]	-5	hSpCas9	negative selection	10620475
25911823	25911846	21	+	28162770	SKM1	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	0.09310940439148141	[34]	[65]	0	hSpCas9	negative selection	10620476
26089931	26089954	21	+	28162770	PL21	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	-0.24916778687426955	[425]	[155]	-2	hSpCas9	negative selection	10789833
25911770	25911793	21	+	28162770	PL21	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	-0.1444436860583529	[352]	[138]	-1	hSpCas9	negative selection	10789834
25911740	25911763	21	-	28162770	PL21	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	-2.6072153075682842	[13]	[0]	-9	hSpCas9	negative selection	10789835
26053284	26053307	21	-	28162770	PL21	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	1.5995151348725758	[300]	[396]	9	hSpCas9	negative selection	10789836
26022014	26022037	21	-	28162770	PL21	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	-0.4110885409256416	[387]	[126]	-3	hSpCas9	negative selection	10789837
25975056	25975079	21	+	28162770	PL21	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-1.1624304648953883	[143]	[27]	-7	hSpCas9	negative selection	10789838
25954656	25954679	21	+	28162770	PL21	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	0.9718706268162032	[40]	[34]	7	hSpCas9	negative selection	10789839
25954614	25954637	21	-	28162770	PL21	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	0.41354325259851343	[68]	[39]	3	hSpCas9	negative selection	10789840
25911837	25911860	21	-	28162770	PL21	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	-0.26934566881190003	[35]	[12]	-2	hSpCas9	negative selection	10789841
25911823	25911846	21	+	28162770	PL21	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	-1.4588234676756127	[119]	[18]	-7	hSpCas9	negative selection	10789842
26089931	26089954	21	+	28162770	P31FUJ	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.17189335064300604	[419]	[555]	1	hSpCas9	negative selection	10959199
25911770	25911793	21	+	28162770	P31FUJ	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	-0.08585233869561393	[428]	[474]	-1	hSpCas9	negative selection	10959200
25911740	25911763	21	-	28162770	P31FUJ	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	-0.9697677985805848	[9]	[5]	-6	hSpCas9	negative selection	10959201
26053284	26053307	21	-	28162770	P31FUJ	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	0.14511583930376548	[373]	[485]	1	hSpCas9	negative selection	10959202
26022014	26022037	21	-	28162770	P31FUJ	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	0.5612131307707862	[356]	[618]	6	hSpCas9	negative selection	10959203
25975056	25975079	21	+	28162770	P31FUJ	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-0.31187377540557737	[74]	[70]	-3	hSpCas9	negative selection	10959204
25954656	25954679	21	+	28162770	P31FUJ	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	0.28592659790669084	[103]	[148]	3	hSpCas9	negative selection	10959205
25954614	25954637	21	-	28162770	P31FUJ	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	0.24026741623588022	[66]	[92]	2	hSpCas9	negative selection	10959206
25911837	25911860	21	-	28162770	P31FUJ	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	0.24524509239026582	[27]	[38]	2	hSpCas9	negative selection	10959207
25911823	25911846	21	+	28162770	P31FUJ	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	-1.5088144642463823	[200]	[82]	-7	hSpCas9	negative selection	10959208
26089931	26089954	21	+	28162770	OCIAML5	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.2284233469963708	[182]	[386]	2	hSpCas9	negative selection	11128565
25911770	25911793	21	+	28162770	OCIAML5	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	0.09325633651568888	[241]	[465]	0	hSpCas9	negative selection	11128566
25911740	25911763	21	-	28162770	OCIAML5	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	-3.1739946657513594	[4]	[0]	-9	hSpCas9	negative selection	11128567
26053284	26053307	21	-	28162770	OCIAML5	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	0.4522185632361154	[180]	[446]	4	hSpCas9	negative selection	11128568
26022014	26022037	21	-	28162770	OCIAML5	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	0.8428443964750457	[180]	[585]	7	hSpCas9	negative selection	11128569
25975056	25975079	21	+	28162770	OCIAML5	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-1.8520665708639967	[69]	[34]	-7	hSpCas9	negative selection	11128570
25954656	25954679	21	+	28162770	OCIAML5	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	0.7328959298571593	[32]	[98]	6	hSpCas9	negative selection	11128571
25954614	25954637	21	-	28162770	OCIAML5	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	1.4698615240233652	[34]	[174]	9	hSpCas9	negative selection	11128572
25911837	25911860	21	-	28162770	OCIAML5	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	1.870399453607094	[9]	[65]	9	hSpCas9	negative selection	11128573
25911823	25911846	21	+	28162770	OCIAML5	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	-2.683466966888252	[120]	[33]	-8	hSpCas9	negative selection	11128574
26089931	26089954	21	+	28162770	EOL1	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.14131564371310423	[770]	[447]	1	hSpCas9	negative selection	11297931
25911770	25911793	21	+	28162770	EOL1	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	0.4037156082690939	[461]	[321]	3	hSpCas9	negative selection	11297932
25911740	25911763	21	-	28162770	EOL1	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	-0.6115051286696755	[28]	[9]	-4	hSpCas9	negative selection	11297933
26053284	26053307	21	-	28162770	EOL1	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	0.8135164591817905	[728]	[674]	7	hSpCas9	negative selection	11297934
26022014	26022037	21	-	28162770	EOL1	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	0.2849500142725325	[591]	[379]	2	hSpCas9	negative selection	11297935
25975056	25975079	21	+	28162770	EOL1	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-0.9746892514945487	[234]	[62]	-6	hSpCas9	negative selection	11297936
25954656	25954679	21	+	28162770	EOL1	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	2.5485798369702835	[84]	[261]	9	hSpCas9	negative selection	11297937
25954614	25954637	21	-	28162770	EOL1	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	1.2386563619985977	[73]	[91]	8	hSpCas9	negative selection	11297938
25911837	25911860	21	-	28162770	EOL1	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	-2.162915069679805	[33]	[3]	-8	hSpCas9	negative selection	11297939
25911823	25911846	21	+	28162770	EOL1	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	0.3395852708493782	[164]	[109]	3	hSpCas9	negative selection	11297940
26089931	26089954	21	+	28162770	MOLM13	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.735111584341806	[515]	[620]	5	hSpCas9	negative selection	11467297
25911770	25911793	21	+	28162770	MOLM13	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	-1.0466837912851796	[599]	[209]	-5	hSpCas9	negative selection	11467298
25911740	25911763	21	-	28162770	MOLM13	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	-4.0556725745124345	[22]	[0]	-9	hSpCas9	negative selection	11467299
26053284	26053307	21	-	28162770	MOLM13	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	0.38177422375598613	[534]	[503]	3	hSpCas9	negative selection	11467300
26022014	26022037	21	-	28162770	MOLM13	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	1.1766804691185933	[423]	[692]	8	hSpCas9	negative selection	11467301
25975056	25975079	21	+	28162770	MOLM13	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-0.6862337637748406	[226]	[101]	-4	hSpCas9	negative selection	11467302
25954656	25954679	21	+	28162770	MOLM13	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	-1.2976453648183983	[118]	[34]	-6	hSpCas9	negative selection	11467303
25954614	25954637	21	-	28162770	MOLM13	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	-0.7104478597139334	[85]	[37]	-4	hSpCas9	negative selection	11467304
25911837	25911860	21	-	28162770	MOLM13	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	-0.8882544286806966	[63]	[24]	-5	hSpCas9	negative selection	11467305
25911823	25911846	21	+	28162770	MOLM13	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	-0.07267899981812409	[143]	[98]	0	hSpCas9	negative selection	11467306
26089931	26089954	21	+	28162770	HEL	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	-0.3542142924407792	[472]	[236]	-2	hSpCas9	negative selection	11636663
25911770	25911793	21	+	28162770	HEL	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	-0.7447776045145822	[449]	[171]	-5	hSpCas9	negative selection	11636664
25911740	25911763	21	-	28162770	HEL	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	0.7358482363918384	[14]	[15]	6	hSpCas9	negative selection	11636665
26053284	26053307	21	-	28162770	HEL	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	-0.21141030153618823	[516]	[285]	-1	hSpCas9	negative selection	11636666
26022014	26022037	21	-	28162770	HEL	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	0.44448510749955006	[404]	[352]	4	hSpCas9	negative selection	11636667
25975056	25975079	21	+	28162770	HEL	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-1.527186169441955	[188]	[41]	-7	hSpCas9	negative selection	11636668
25954656	25954679	21	+	28162770	HEL	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	-1.5347993535518307	[94]	[20]	-7	hSpCas9	negative selection	11636669
25954614	25954637	21	-	28162770	HEL	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	-0.24178395057970725	[47]	[25]	-2	hSpCas9	negative selection	11636670
25911837	25911860	21	-	28162770	HEL	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	-4.215242163127215	[28]	[0]	-9	hSpCas9	negative selection	11636671
25911823	25911846	21	+	28162770	HEL	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	-1.2927209158049326	[152]	[39]	-6	hSpCas9	negative selection	11636672
26089931	26089954	21	+	28162770	MV411	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	-0.8680396666371606	[389]	[179]	-5	hSpCas9	negative selection	11806029
25911770	25911793	21	+	28162770	MV411	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	0.47430344869853125	[275]	[322]	4	hSpCas9	negative selection	11806030
25911740	25911763	21	-	28162770	MV411	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	1.0200270546797028	[23]	[40]	8	hSpCas9	negative selection	11806031
26053284	26053307	21	-	28162770	MV411	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	0.20304343142432213	[428]	[415]	1	hSpCas9	negative selection	11806032
26022014	26022037	21	-	28162770	MV411	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	0.49930985032926933	[345]	[411]	4	hSpCas9	negative selection	11806033
25975056	25975079	21	+	28162770	MV411	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-1.480482903780424	[105]	[31]	-7	hSpCas9	negative selection	11806034
25954656	25954679	21	+	28162770	MV411	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	0.15997470953243598	[33]	[31]	1	hSpCas9	negative selection	11806035
25954614	25954637	21	-	28162770	MV411	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	0.6624750500616191	[62]	[83]	6	hSpCas9	negative selection	11806036
25911837	25911860	21	-	28162770	MV411	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	1.8478300920735375	[30]	[93]	9	hSpCas9	negative selection	11806037
25911823	25911846	21	+	28162770	MV411	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	-1.4658490469139203	[140]	[42]	-7	hSpCas9	negative selection	11806038
26089931	26089954	21	+	28162770	MONOMAC1	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.22963535270269309	[246]	[331]	2	hSpCas9	negative selection	11975395
25911770	25911793	21	+	28162770	MONOMAC1	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	0.23198488165499154	[230]	[310]	2	hSpCas9	negative selection	11975396
25911740	25911763	21	-	28162770	MONOMAC1	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	-4.518964941946916	[19]	[0]	-9	hSpCas9	negative selection	11975397
26053284	26053307	21	-	28162770	MONOMAC1	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	0.2549948597014918	[230]	[315]	2	hSpCas9	negative selection	11975398
26022014	26022037	21	-	28162770	MONOMAC1	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	0.15591814344843324	[183]	[234]	1	hSpCas9	negative selection	11975399
25975056	25975079	21	+	28162770	MONOMAC1	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	0.022529530198130754	[72]	[84]	0	hSpCas9	negative selection	11975400
25954656	25954679	21	+	28162770	MONOMAC1	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	-0.5189649419469161	[64]	[51]	-4	hSpCas9	negative selection	11975401
25954614	25954637	21	-	28162770	MONOMAC1	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	-0.05264693772437923	[37]	[41]	0	hSpCas9	negative selection	11975402
25911837	25911860	21	-	28162770	MONOMAC1	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	0.6394644206575668	[13]	[24]	6	hSpCas9	negative selection	11975403
25911823	25911846	21	+	28162770	MONOMAC1	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	0.2645432381563203	[60]	[83]	2	hSpCas9	negative selection	11975404
26089931	26089954	21	+	28162770	OCIAML2	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	0.662853180232091	[48]	[429]	6	hSpCas9	negative selection	12144761
25911770	25911793	21	+	28162770	OCIAML2	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	0.2631960613934777	[45]	[305]	2	hSpCas9	negative selection	12144762
25911740	25911763	21	-	28162770	OCIAML2	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	1.0212232710875133	[3]	[44]	8	hSpCas9	negative selection	12144763
26053284	26053307	21	-	28162770	OCIAML2	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	-0.2519224507135691	[83]	[390]	-2	hSpCas9	negative selection	12144764
26022014	26022037	21	-	28162770	OCIAML2	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	0.2546539638764097	[61]	[409]	2	hSpCas9	negative selection	12144765
25975056	25975079	21	+	28162770	OCIAML2	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-1.58798677588032	[31]	[58]	-7	hSpCas9	negative selection	12144766
25954656	25954679	21	+	28162770	OCIAML2	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	1.2017955167293342	[7]	[101]	9	hSpCas9	negative selection	12144767
25954614	25954637	21	-	28162770	OCIAML2	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	0.6378946315360077	[7]	[68]	6	hSpCas9	negative selection	12144768
25911837	25911860	21	-	28162770	OCIAML2	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	-0.055592325963317535	[2]	[15]	0	hSpCas9	negative selection	12144769
25911823	25911846	21	+	28162770	OCIAML2	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	-0.8649087643542076	[22]	[69]	-6	hSpCas9	negative selection	12144770
26089931	26089954	21	+	28162770	OCIAML3	viability	CGGCCGGCTCACCTAAGCAGCGG	APP	ENSG00000142192	-0.16162289748142256	[92]	[250]	-1	hSpCas9	negative selection	12314127
25911770	25911793	21	+	28162770	OCIAML3	viability	TCAGCCCCAAAAGAATGCCACGG	APP	ENSG00000142192	-0.18237674248856883	[105]	[281]	-1	hSpCas9	negative selection	12314128
25911740	25911763	21	-	28162770	OCIAML3	viability	CCAGCCAACACAGAAAACGAAGG	APP	ENSG00000142192	1.0249021923203305	[6]	[42]	8	hSpCas9	negative selection	12314129
26053284	26053307	21	-	28162770	OCIAML3	viability	GCAAATTCTTACACCAGGAGAGG	APP	ENSG00000142192	0.5759173611181492	[105]	[476]	5	hSpCas9	negative selection	12314130
26022014	26022037	21	-	28162770	OCIAML3	viability	CAAAGTAGTAGAAGTAGCAGAGG	APP	ENSG00000142192	1.2584351712619788	[107]	[779]	9	hSpCas9	negative selection	12314131
25975056	25975079	21	+	28162770	OCIAML3	viability	GCAGCGAGACCTACCCGAGGAGG	APP	ENSG00000142192	-0.9882865794362097	[22]	[34]	-6	hSpCas9	negative selection	12314132
25954656	25954679	21	+	28162770	OCIAML3	viability	TGCGCTCATAAATCACACGGAGG	APP	ENSG00000142192	2.681270361264378	[10]	[212]	9	hSpCas9	negative selection	12314133
25954614	25954637	21	-	28162770	OCIAML3	viability	GCTCTACAACGTGCCTGCAGTGG	APP	ENSG00000142192	2.0088767683942557	[19]	[242]	9	hSpCas9	negative selection	12314134
25911837	25911860	21	-	28162770	OCIAML3	viability	GACCGAAACGAAAACCACCGTGG	APP	ENSG00000142192	-2.7639326417664756	[8]	[3]	-9	hSpCas9	negative selection	12314135
25911823	25911846	21	+	28162770	OCIAML3	viability	CACGGGAAGGAGCTCCACGGTGG	APP	ENSG00000142192	0.5936193628516082	[35]	[163]	5	hSpCas9	negative selection	12314136