Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 23418
• Symbol: CRB1
• Description: crumbs cell polarity complex component 1

DataSource: http://genomecrispr.dkfz.de/#!/results/CRB1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
197328567	197328590	1	-	26472758	Jiyoye	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.39149375927360375	[184]	[182]	3	hSpCas9	negative selection	36733
197421564	197421587	1	-	26472758	Jiyoye	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	-0.36469582760853414	[501]	[293]	-3	hSpCas9	negative selection	36734
197328697	197328720	1	+	26472758	Jiyoye	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.4917088917175413	[231]	[245]	3	hSpCas9	negative selection	36735
197356975	197356998	1	-	26472758	Jiyoye	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	2.007445135014878	[124]	[378]	8	hSpCas9	negative selection	36736
197421319	197421342	1	+	26472758	Jiyoye	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	0.046919167959411645	[266]	[207]	0	hSpCas9	negative selection	36737
197421361	197421384	1	-	26472758	Jiyoye	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	0.2613245150424188	[103]	[93]	2	hSpCas9	negative selection	36738
197421500	197421523	1	+	26472758	Jiyoye	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	1.3811801729729287	[27]	[54]	8	hSpCas9	negative selection	36739
197421535	197421558	1	+	26472758	Jiyoye	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	0.6339462433528957	[46]	[54]	4	hSpCas9	negative selection	36740
197328891	197328914	1	+	26472758	Jiyoye	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	-0.16681600139427943	[261]	[175]	-1	hSpCas9	negative selection	36741
197328567	197328590	1	-	26472758	KBM7	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.15562628586045002	[601,505]	[307,271]	1	hSpCas9	negative selection	227851
197421564	197421587	1	-	26472758	KBM7	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.4615306475854779	[2023,1887]	[1011,1496]	5	hSpCas9	negative selection	227852
197328697	197328720	1	+	26472758	KBM7	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.18600831271051832	[1156,946]	[555,562]	2	hSpCas9	negative selection	227853
197356975	197356998	1	-	26472758	KBM7	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	0.8211261856402855	[1090,735]	[832,670]	8	hSpCas9	negative selection	227854
197421319	197421342	1	+	26472758	KBM7	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	0.3180222697239514	[1247,890]	[680,563]	3	hSpCas9	negative selection	227855
197421361	197421384	1	-	26472758	KBM7	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	-0.18775435484381497	[319,201]	[109,101]	-2	hSpCas9	negative selection	227856
197421500	197421523	1	+	26472758	KBM7	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	0.04451505076918261	[305,414]	[161,192]	0	hSpCas9	negative selection	227857
197421535	197421558	1	+	26472758	KBM7	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	-0.17374618437372297	[443,310]	[130,176]	-2	hSpCas9	negative selection	227858
197328891	197328914	1	+	26472758	KBM7	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.31823271022176425	[887,985]	[584,527]	3	hSpCas9	negative selection	227859
197328567	197328590	1	-	26472758	Raji	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.20405955478527332	[302]	[80]	2	hSpCas9	negative selection	418969
197421564	197421587	1	-	26472758	Raji	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.14916194768936775	[986]	[253]	1	hSpCas9	negative selection	418970
197328697	197328720	1	+	26472758	Raji	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.793917019234433	[424]	[170]	7	hSpCas9	negative selection	418971
197356975	197356998	1	-	26472758	Raji	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	-0.09977437226768815	[470]	[101]	-1	hSpCas9	negative selection	418972
197421319	197421342	1	+	26472758	Raji	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	-0.1738308865252154	[558]	[114]	-1	hSpCas9	negative selection	418973
197421361	197421384	1	-	26472758	Raji	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	-0.5002990418476401	[127]	[20]	-4	hSpCas9	negative selection	418974
197421500	197421523	1	+	26472758	Raji	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	0.4604932855092416	[118]	[37]	4	hSpCas9	negative selection	418975
197421535	197421558	1	+	26472758	Raji	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	-0.4086316116300652	[285]	[49]	-3	hSpCas9	negative selection	418976
197328891	197328914	1	+	26472758	Raji	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.26171168176489346	[495]	[137]	2	hSpCas9	negative selection	418977
197328567	197328590	1	-	26472758	K562	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.37694886513790915	[633]	[694]	3	hSpCas9	negative selection	610087
197421564	197421587	1	-	26472758	K562	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.8410360699447388	[1725]	[2609]	7	hSpCas9	negative selection	610088
197328697	197328720	1	+	26472758	K562	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.6043146727528299	[839]	[1077]	5	hSpCas9	negative selection	610089
197356975	197356998	1	-	26472758	K562	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	0.6759208283630234	[696]	[939]	5	hSpCas9	negative selection	610090
197421319	197421342	1	+	26472758	K562	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	0.481766489836591	[849]	[1001]	4	hSpCas9	negative selection	610091
197421361	197421384	1	-	26472758	K562	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	0.8476203466726455	[130]	[198]	7	hSpCas9	negative selection	610092
197421500	197421523	1	+	26472758	K562	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	0.47118958951346906	[234]	[274]	4	hSpCas9	negative selection	610093
197421535	197421558	1	+	26472758	K562	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	-0.8778370223845513	[319]	[146]	-5	hSpCas9	negative selection	610094
197328891	197328914	1	+	26472758	K562	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.5425850049602434	[905]	[1113]	4	hSpCas9	negative selection	610095
197328759	197328782	1	-	26627737	DLD1	viability	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.6165381196229645	[627]	[217,388,299]	6	hSpCas9	negative selection	768206
197347354	197347377	1	+	26627737	DLD1	viability	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	-0.3049324483042538	[412]	[118,130,69]	-3	hSpCas9	negative selection	768207
197356844	197356867	1	-	26627737	DLD1	viability	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	0.6696946442469326	[532]	[203,398,206]	6	hSpCas9	negative selection	768208
197421242	197421265	1	-	26627737	DLD1	viability	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	-0.15875028977406624	[162]	[44,63,30]	-2	hSpCas9	negative selection	768209
197427612	197427635	1	+	26627737	DLD1	viability	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	-0.5221537369661214	[755]	[178,195,125]	-5	hSpCas9	negative selection	768210
197429052	197429075	1	+	26627737	DLD1	viability	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.10553042051744432	[691]	[290,232,181]	1	hSpCas9	negative selection	768211
197328759	197328782	1	-	26627737	GBM cells	viability after 5 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.027237971861225008	[386]	[193,228]	0	hSpCas9	negative selection	850521
197347354	197347377	1	+	26627737	GBM cells	viability after 5 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.39282439547893877	[217]	[152,153]	6	hSpCas9	negative selection	850522
197356844	197356867	1	-	26627737	GBM cells	viability after 5 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	0.09321754090984585	[325]	[200,171]	1	hSpCas9	negative selection	850523
197421242	197421265	1	-	26627737	GBM cells	viability after 5 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	0.21708983491194034	[76]	[33,61]	3	hSpCas9	negative selection	850524
197427612	197427635	1	+	26627737	GBM cells	viability after 5 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	-0.3334488352056906	[362]	[174,133]	-5	hSpCas9	negative selection	850525
197429052	197429075	1	+	26627737	GBM cells	viability after 5 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.33317594142942764	[409]	[242,310]	5	hSpCas9	negative selection	850526
197328759	197328782	1	-	26627737	GBM cells	viability after 13 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.14302533801993644	[386]	[302,173]	1	hSpCas9	negative selection	932836
197347354	197347377	1	+	26627737	GBM cells	viability after 13 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.11797398902366088	[217]	[161,100]	1	hSpCas9	negative selection	932837
197356844	197356867	1	-	26627737	GBM cells	viability after 13 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	0.03234146815890632	[325]	[165,192]	0	hSpCas9	negative selection	932838
197421242	197421265	1	-	26627737	GBM cells	viability after 13 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	0.3581708714434142	[76]	[52,53]	4	hSpCas9	negative selection	932839
197427612	197427635	1	+	26627737	GBM cells	viability after 13 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	0.005113732690656736	[362]	[195,198]	0	hSpCas9	negative selection	932840
197429052	197429075	1	+	26627737	GBM cells	viability after 13 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.661120108261866	[409]	[380,327]	7	hSpCas9	negative selection	932841
197328759	197328782	1	-	26627737	GBM cells	viability after 21 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.6310004328501326	[386]	[334,316]	6	hSpCas9	negative selection	1015151
197347354	197347377	1	+	26627737	GBM cells	viability after 21 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	-0.19601368654442874	[217]	[105,100]	-2	hSpCas9	negative selection	1015152
197356844	197356867	1	-	26627737	GBM cells	viability after 21 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-0.5133939116655379	[325]	[133,114]	-4	hSpCas9	negative selection	1015153
197421242	197421265	1	-	26627737	GBM cells	viability after 21 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	0.37780235111846894	[76]	[45,61]	4	hSpCas9	negative selection	1015154
197427612	197427635	1	+	26627737	GBM cells	viability after 21 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	0.19488322390703094	[362]	[231,219]	2	hSpCas9	negative selection	1015155
197429052	197429075	1	+	26627737	GBM cells	viability after 21 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.7620623627826838	[409]	[406,350]	7	hSpCas9	negative selection	1015156
197328759	197328782	1	-	26627737	RPE1	viability after 9 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.5572409280965278	[1065]	[339,685]	4	hSpCas9	negative selection	1097466
197347354	197347377	1	+	26627737	RPE1	viability after 9 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	2.160833592458643	[145]	[244,151]	9	hSpCas9	negative selection	1097467
197356844	197356867	1	-	26627737	RPE1	viability after 9 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-0.5516051268040723	[1391]	[240,369]	-4	hSpCas9	negative selection	1097468
197421242	197421265	1	-	26627737	RPE1	viability after 9 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	0.8095722167857108	[241]	[120,147]	5	hSpCas9	negative selection	1097469
197427612	197427635	1	+	26627737	RPE1	viability after 9 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	2.3521682532364854	[398]	[694,563]	9	hSpCas9	negative selection	1097470
197429052	197429075	1	+	26627737	RPE1	viability after 9 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.5894895734624396	[1555]	[670,812]	4	hSpCas9	negative selection	1097471
197328759	197328782	1	-	26627737	RPE1	viability after 12 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	1.022499175126906	[1065]	[557,606]	6	hSpCas9	negative selection	1179781
197347354	197347377	1	+	26627737	RPE1	viability after 12 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	2.9464648666317714	[145]	[365,234]	9	hSpCas9	negative selection	1179782
197356844	197356867	1	-	26627737	RPE1	viability after 12 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-0.13115066833131983	[1391]	[323,359]	-1	hSpCas9	negative selection	1179783
197421242	197421265	1	-	26627737	RPE1	viability after 12 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	1.0197674461365596	[241]	[176,83]	6	hSpCas9	negative selection	1179784
197427612	197427635	1	+	26627737	RPE1	viability after 12 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	1.9929930757039784	[398]	[348,508]	8	hSpCas9	negative selection	1179785
197429052	197429075	1	+	26627737	RPE1	viability after 12 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.5402091783338897	[1555]	[621,592]	3	hSpCas9	negative selection	1179786
197328759	197328782	1	-	26627737	RPE1	viability after 15 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.7679839738257317	[1065]	[428,594]	5	hSpCas9	negative selection	1262096
197347354	197347377	1	+	26627737	RPE1	viability after 15 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	2.8804422368074416	[145]	[493,120]	9	hSpCas9	negative selection	1262097
197356844	197356867	1	-	26627737	RPE1	viability after 15 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	0.15744003351833524	[1391]	[513,366]	1	hSpCas9	negative selection	1262098
197421242	197421265	1	-	26627737	RPE1	viability after 15 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	0.784947684793784	[241]	[204,33]	5	hSpCas9	negative selection	1262099
197427612	197427635	1	+	26627737	RPE1	viability after 15 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	1.8910712270947958	[398]	[241,588]	8	hSpCas9	negative selection	1262100
197429052	197429075	1	+	26627737	RPE1	viability after 15 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.4313807292671171	[1555]	[589,596]	2	hSpCas9	negative selection	1262101
197328759	197328782	1	-	26627737	RPE1	viability after 18 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.8001795507675182	[1065]	[440,564]	5	hSpCas9	negative selection	1344411
197347354	197347377	1	+	26627737	RPE1	viability after 18 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	2.885306331557999	[145]	[381,193]	9	hSpCas9	negative selection	1344412
197356844	197356867	1	-	26627737	RPE1	viability after 18 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-0.1581116983336277	[1391]	[253,424]	-1	hSpCas9	negative selection	1344413
197421242	197421265	1	-	26627737	RPE1	viability after 18 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	1.7108335176589087	[241]	[396,17]	8	hSpCas9	negative selection	1344414
197427612	197427635	1	+	26627737	RPE1	viability after 18 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	1.9077025022424738	[398]	[389,418]	8	hSpCas9	negative selection	1344415
197429052	197429075	1	+	26627737	RPE1	viability after 18 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.41610613962748266	[1555]	[539,581]	2	hSpCas9	negative selection	1344416
197328759	197328782	1	-	26627737	HeLa	viability after 8 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	-0.10023000935764384	[437]	[74,216,215]	-1	hSpCas9	negative selection	1426726
197347354	197347377	1	+	26627737	HeLa	viability after 8 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	-0.11791866025364584	[315]	[134,194,56]	-1	hSpCas9	negative selection	1426727
197356844	197356867	1	-	26627737	HeLa	viability after 8 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-1.1549689034848165	[679]	[225,87,106]	-8	hSpCas9	negative selection	1426728
197421242	197421265	1	-	26627737	HeLa	viability after 8 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	-1.7283854131555862	[162]	[54,0,15]	-9	hSpCas9	negative selection	1426729
197427612	197427635	1	+	26627737	HeLa	viability after 8 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	1.3571381484314533	[252]	[305,361,189]	8	hSpCas9	negative selection	1426730
197429052	197429075	1	+	26627737	HeLa	viability after 8 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	-0.7159708160823033	[1214]	[486,445,85]	-6	hSpCas9	negative selection	1426731
197328759	197328782	1	-	26627737	HeLa	viability after 12 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.09201269807104806	[437]	[151,292,121]	0	hSpCas9	negative selection	1509041
197347354	197347377	1	+	26627737	HeLa	viability after 12 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.7728586270150066	[315]	[252,187,232]	6	hSpCas9	negative selection	1509042
197356844	197356867	1	-	26627737	HeLa	viability after 12 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-1.3990116955934702	[679]	[138,102,78]	-8	hSpCas9	negative selection	1509043
197421242	197421265	1	-	26627737	HeLa	viability after 12 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	-0.39940998912418757	[162]	[54,6,95]	-4	hSpCas9	negative selection	1509044
197427612	197427635	1	+	26627737	HeLa	viability after 12 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	1.0371307211968634	[252]	[287,127,238]	7	hSpCas9	negative selection	1509045
197429052	197429075	1	+	26627737	HeLa	viability after 12 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.0006823879997286397	[1214]	[842,284,411]	0	hSpCas9	negative selection	1509046
197328759	197328782	1	-	26627737	HeLa	viability after 15 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.47178399446463937	[437]	[297,137,309]	4	hSpCas9	negative selection	1591356
197347354	197347377	1	+	26627737	HeLa	viability after 15 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.009141967350830837	[315]	[60,189,138]	0	hSpCas9	negative selection	1591357
197356844	197356867	1	-	26627737	HeLa	viability after 15 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-1.6726022099815305	[679]	[61,109,88]	-8	hSpCas9	negative selection	1591358
197421242	197421265	1	-	26627737	HeLa	viability after 15 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	-1.6047248000103205	[162]	[33,0,30]	-8	hSpCas9	negative selection	1591359
197427612	197427635	1	+	26627737	HeLa	viability after 15 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	1.4441061916797364	[252]	[369,123,350]	8	hSpCas9	negative selection	1591360
197429052	197429075	1	+	26627737	HeLa	viability after 15 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	-0.23381844210615954	[1214]	[490,360,407]	-2	hSpCas9	negative selection	1591361
197328759	197328782	1	-	26627737	HeLa	viability after 18 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.453789166671286	[437]	[198,107,309]	4	hSpCas9	negative selection	1673671
197347354	197347377	1	+	26627737	HeLa	viability after 18 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.03981364424789319	[315]	[40,163,138]	0	hSpCas9	negative selection	1673672
197356844	197356867	1	-	26627737	HeLa	viability after 18 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-1.6327271707335171	[679]	[43,93,88]	-8	hSpCas9	negative selection	1673673
197421242	197421265	1	-	26627737	HeLa	viability after 18 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	-1.4959150499010974	[162]	[25,0,30]	-8	hSpCas9	negative selection	1673674
197427612	197427635	1	+	26627737	HeLa	viability after 18 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	1.4109151493532774	[252]	[233,104,350]	8	hSpCas9	negative selection	1673675
197429052	197429075	1	+	26627737	HeLa	viability after 18 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	-0.21347115091472735	[1214]	[344,293,407]	-2	hSpCas9	negative selection	1673676
197328759	197328782	1	-	26627737	HCT116	viability after 6 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	2.5023175224203635	[567]	[911,281]	9	hSpCas9	negative selection	1755986
197347354	197347377	1	+	26627737	HCT116	viability after 6 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.4031616508500684	[666]	[157,127]	2	hSpCas9	negative selection	1755987
197356844	197356867	1	-	26627737	HCT116	viability after 6 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	1.2476343125400482	[517]	[135,224]	6	hSpCas9	negative selection	1755988
197421242	197421265	1	-	26627737	HCT116	viability after 6 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	0.577436274658506	[178]	[99,9]	3	hSpCas9	negative selection	1755989
197427612	197427635	1	+	26627737	HCT116	viability after 6 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	1.3664284489452392	[487]	[327,125]	7	hSpCas9	negative selection	1755990
197429052	197429075	1	+	26627737	HCT116	viability after 6 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	-0.27332386305249967	[1282]	[182,157]	-1	hSpCas9	negative selection	1755991
197328759	197328782	1	-	26627737	HCT116	viability after 8 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.9893915911526409	[179]	[208,187,193]	8	hSpCas9	negative selection	1838301
197347354	197347377	1	+	26627737	HCT116	viability after 8 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.8005739461893742	[149]	[137,166,126]	7	hSpCas9	negative selection	1838302
197356844	197356867	1	-	26627737	HCT116	viability after 8 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-0.09892570210771101	[355]	[166,181,199]	-1	hSpCas9	negative selection	1838303
197421242	197421265	1	-	26627737	HCT116	viability after 8 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	0.8625476321424443	[68]	[46,90,68]	7	hSpCas9	negative selection	1838304
197427612	197427635	1	+	26627737	HCT116	viability after 8 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	0.7785451675666446	[266]	[327,220,209]	7	hSpCas9	negative selection	1838305
197429052	197429075	1	+	26627737	HCT116	viability after 8 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	-0.5341748161507294	[845]	[277,450,236]	-6	hSpCas9	negative selection	1838306
197328759	197328782	1	-	26627737	HCT116	viability after 9 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	2.016935286032818	[567]	[748,506]	9	hSpCas9	negative selection	1920616
197347354	197347377	1	+	26627737	HCT116	viability after 9 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	-0.43906801998480216	[666]	[41,201]	-3	hSpCas9	negative selection	1920617
197356844	197356867	1	-	26627737	HCT116	viability after 9 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	1.1771203224332507	[517]	[252,359]	7	hSpCas9	negative selection	1920618
197421242	197421265	1	-	26627737	HCT116	viability after 9 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	2.1957830381466987	[178]	[99,312]	9	hSpCas9	negative selection	1920619
197427612	197427635	1	+	26627737	HCT116	viability after 9 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	0.21282935188700114	[487]	[250,71]	1	hSpCas9	negative selection	1920620
197429052	197429075	1	+	26627737	HCT116	viability after 9 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.3588565105506818	[1282]	[211,618]	2	hSpCas9	negative selection	1920621
197328759	197328782	1	-	26627737	HCT116	viability after 12 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	1.2266471788233515	[179]	[290,179,185]	8	hSpCas9	negative selection	2002931
197347354	197347377	1	+	26627737	HCT116	viability after 12 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	-0.135748751333292	[149]	[60,104,50]	-1	hSpCas9	negative selection	2002932
197356844	197356867	1	-	26627737	HCT116	viability after 12 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	0.4678525486236873	[355]	[309,268,192]	4	hSpCas9	negative selection	2002933
197421242	197421265	1	-	26627737	HCT116	viability after 12 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	0.4633973194764407	[68]	[11,118,23]	4	hSpCas9	negative selection	2002934
197427612	197427635	1	+	26627737	HCT116	viability after 12 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	0.6606753632142207	[266]	[229,191,241]	6	hSpCas9	negative selection	2002935
197429052	197429075	1	+	26627737	HCT116	viability after 12 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	-0.40394496117721035	[845]	[384,345,272]	-4	hSpCas9	negative selection	2002936
197328759	197328782	1	-	26627737	HCT116	viability after 15 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.5395865226562427	[179]	[209,176,71]	5	hSpCas9	negative selection	2085246
197347354	197347377	1	+	26627737	HCT116	viability after 15 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.69414939729376	[149]	[136,154,125]	6	hSpCas9	negative selection	2085247
197356844	197356867	1	-	26627737	HCT116	viability after 15 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-0.03695401574943763	[355]	[199,287,110]	0	hSpCas9	negative selection	2085248
197421242	197421265	1	-	26627737	HCT116	viability after 15 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	0.7164667577971451	[68]	[44,91,55]	6	hSpCas9	negative selection	2085249
197427612	197427635	1	+	26627737	HCT116	viability after 15 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	1.251622301563606	[266]	[256,528,296]	8	hSpCas9	negative selection	2085250
197429052	197429075	1	+	26627737	HCT116	viability after 15 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	-0.4240763327908248	[845]	[458,431,208]	-4	hSpCas9	negative selection	2085251
197328759	197328782	1	-	26627737	HCT116	viability after 18 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	1.1335953432359323	[179]	[240,159,172]	8	hSpCas9	negative selection	2167561
197347354	197347377	1	+	26627737	HCT116	viability after 18 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	1.0876844664330354	[149]	[137,103,226]	8	hSpCas9	negative selection	2167562
197356844	197356867	1	-	26627737	HCT116	viability after 18 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-0.029870060310166174	[355]	[270,72,167]	0	hSpCas9	negative selection	2167563
197421242	197421265	1	-	26627737	HCT116	viability after 18 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	0.900650567041716	[68]	[10,98,74]	7	hSpCas9	negative selection	2167564
197427612	197427635	1	+	26627737	HCT116	viability after 18 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	1.5620933858497772	[266]	[293,497,341]	9	hSpCas9	negative selection	2167565
197429052	197429075	1	+	26627737	HCT116	viability after 18 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	-0.36212183117042285	[845]	[404,287,260]	-3	hSpCas9	negative selection	2167566
197430971	197430994	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	TGGGAGGACTGCTTGAGCCCAAG	CRB1	ENSG00000134376	0.7107825170273987	[226,48]	[71,23]	3	dCas9-VP64	positive selection	2383369
197331913	197331936	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCCTGTAATCCCAGCACTTTCGG	CRB1	ENSG00000134376	0.14000166748158183	[525,123]	[99,52]	0	dCas9-VP64	positive selection	2444625
197430971	197430994	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	TGGGAGGACTGCTTGAGCCCAAG	CRB1	ENSG00000134376	0.4123872135065094	[127,354]	[119,88]	3	dCas9-VP64	positive selection	2478624
197331913	197331936	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCCTGTAATCCCAGCACTTTCGG	CRB1	ENSG00000134376	2.3170246663226814	[189,235]	[324,366]	8	dCas9-VP64	positive selection	2539880
197328567	197328590	1	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.21848551905596142	[4,4]	[4,4]	4	hSpCas9	positive selection	2981028
197347355	197347378	1	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.23518740373391733	[4,4]	[4,4]	5	hSpCas9	positive selection	2981029
197328680	197328703	1	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTTCTTGCCACAGGAACCAATGG	CRB1	ENSG00000134376	0.04301392866216025	[2,3]	[1,2]	0	hSpCas9	positive selection	2981030
197328925	197328948	1	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTCAGATCCCTGCAAGAACGAGG	CRB1	ENSG00000134376	-0.3748745540387821	[3,3]	[2,1]	-5	hSpCas9	positive selection	2981031
197328567	197328590	1	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.18587952846450723	[4,4]	[4,2]	3	hSpCas9	positive selection	3048886
197347355	197347378	1	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.26355276528850335	[4,4]	[5,2]	4	hSpCas9	positive selection	3048887
197328680	197328703	1	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTTCTTGCCACAGGAACCAATGG	CRB1	ENSG00000134376	-0.01551978095749465	[2,2]	[0,2]	0	hSpCas9	positive selection	3048888
197328925	197328948	1	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTCAGATCCCTGCAAGAACGAGG	CRB1	ENSG00000134376	-0.4306087029019754	[3,3]	[0,1]	-6	hSpCas9	positive selection	3048889
197268451	197268474		-	24336571	A375	resistance to PLX after 7 days	AGATAAGCAGTGAGAAACTGAGG	CRB1	ENSG00000134376	0.09910918240252425	[18,16]	[19,17]	3	hSpCas9	positive selection	3107283
197328990	197329013		-	24336571	A375	resistance to PLX after 7 days	CACACTTACCAGAATAATTGTGG	CRB1	ENSG00000134376	0.250385855418523	[20,22]	[26,24]	7	hSpCas9	positive selection	3107284
197328931	197328954		-	24336571	A375	resistance to PLX after 7 days	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.13047912439818976	[64,69]	[59,62]	-4	hSpCas9	positive selection	3107286
197268411	197268434		-	24336571	A375	resistance to PLX after 7 days	GTTAATGTTCTTAAGTGCCATGG	CRB1	ENSG00000134376	0.03338265747885205	[25,21]	[23,23]	1	hSpCas9	positive selection	3107287
197328885	197328908		+	24336571	A375	resistance to PLX after 7 days	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.1346955522162392	[50,54]	[53,60]	4	hSpCas9	positive selection	3107288
197268451	197268474		-	24336571	A375	resistance to PLX after 14 days	AGATAAGCAGTGAGAAACTGAGG	CRB1	ENSG00000134376	-0.5766215551943624	[13,18]	[4,4]	-6	hSpCas9	positive selection	3165076
197328990	197329013		-	24336571	A375	resistance to PLX after 14 days	CACACTTACCAGAATAATTGTGG	CRB1	ENSG00000134376	0.5586031052389778	[23,24]	[15,17]	5	hSpCas9	positive selection	3165077
197328931	197328954		-	24336571	A375	resistance to PLX after 14 days	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.21533074632624594	[65,54]	[32,31]	2	hSpCas9	positive selection	3165079
197268411	197268434		-	24336571	A375	resistance to PLX after 14 days	GTTAATGTTCTTAAGTGCCATGG	CRB1	ENSG00000134376	0.1597735167352634	[17,18]	[10,7]	1	hSpCas9	positive selection	3165080
197328885	197328908		+	24336571	A375	resistance to PLX after 14 days	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.6782920725519923	[46,56]	[36,40]	6	hSpCas9	positive selection	3165081
197268451	197268474		-	24336571	A375	viability after 7 days	AGATAAGCAGTGAGAAACTGAGG	CRB1	ENSG00000134376	-0.3392627584083639	[23]	[18,16]	-5	hSpCas9	negative selection	3222869
197328990	197329013		-	24336571	A375	viability after 7 days	CACACTTACCAGAATAATTGTGG	CRB1	ENSG00000134376	-0.8926479192182312	[42]	[20,22]	-8	hSpCas9	negative selection	3222870
197328931	197328954		-	24336571	A375	viability after 7 days	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.43215436012328534	[52]	[64,69]	6	hSpCas9	negative selection	3222872
197268411	197268434		-	24336571	A375	viability after 7 days	GTTAATGTTCTTAAGTGCCATGG	CRB1	ENSG00000134376	-0.4368375123501218	[33]	[25,21]	-6	hSpCas9	negative selection	3222873
197328885	197328908		+	24336571	A375	viability after 7 days	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.07008750198136338	[52]	[50,54]	1	hSpCas9	negative selection	3222874
197268451	197268474		-	24336571	A375	viability after 14 days	AGATAAGCAGTGAGAAACTGAGG	CRB1	ENSG00000134376	-0.42917328740674116	[23]	[13,18]	-5	hSpCas9	negative selection	3280662
197328990	197329013		-	24336571	A375	viability after 14 days	CACACTTACCAGAATAATTGTGG	CRB1	ENSG00000134376	-0.7039380677811234	[42]	[23,24]	-7	hSpCas9	negative selection	3280663
197328931	197328954		-	24336571	A375	viability after 14 days	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.28718042961671286	[52]	[65,54]	4	hSpCas9	negative selection	3280665
197268411	197268434		-	24336571	A375	viability after 14 days	GTTAATGTTCTTAAGTGCCATGG	CRB1	ENSG00000134376	-0.7667247754202944	[33]	[17,18]	-7	hSpCas9	negative selection	3280666
197328885	197328908		+	24336571	A375	viability after 14 days	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.06980565222238044	[52]	[46,56]	0	hSpCas9	negative selection	3280667
197328885	197328908	1	+	27383988	293T	resistance to West Nile virus (flavivirus)	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.5365373783465893	[208,234]	[0,0]	-4	hSpCas9	positive selection	3344474
197328931	197328954	1	-	27383988	293T	resistance to West Nile virus (flavivirus)	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.5535184084501804	[230,217]	[0,0]	-4	hSpCas9	positive selection	3344475
197344336	197344359	1	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-1.0990754103340932	[287,367]	[0,0]	-7	hSpCas9	positive selection	3344476
197344313	197344336	1	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.9905396707509337	[76,76]	[0,0]	4	hSpCas9	positive selection	3363701
197328567	197328590	1	-	26780180	HT29	viability (Avana library 4 designs)	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.803327895369648	[]	[]	3	hSpCas9	negative selection	3417502
197347354	197347377	1	+	26780180	HT29	viability (Avana library 4 designs)	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	-0.230282239485733	[]	[]	-4	hSpCas9	negative selection	3417503
197328680	197328703	1	-	26780180	HT29	viability (Avana library 4 designs)	GTTCTTGCCACAGGAACCAATGG	CRB1	ENSG00000134376	1.09274420336948	[]	[]	4	hSpCas9	negative selection	3417504
197328924	197328947	1	+	26780180	HT29	viability (Avana library 4 designs)	TTCAGATCCCTGCAAGAACGAGG	CRB1	ENSG00000134376	0.587294099584113	[]	[]	2	hSpCas9	negative selection	3417505
197347354	197347377	1	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	2.94359745603144	[]	[]	4	hSpCas9	negative selection	3495539
197328924	197328947	1	+	26780180	A375	viability (Avana lentiCRISPRv2)	TTCAGATCCCTGCAAGAACGAGG	CRB1	ENSG00000134376	2.93902360403335	[]	[]	4	hSpCas9	negative selection	3495540
197328567	197328590	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	2.49481798077804	[]	[]	4	hSpCas9	negative selection	3495541
197328680	197328703	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTTCTTGCCACAGGAACCAATGG	CRB1	ENSG00000134376	3.12416309693632	[]	[]	5	hSpCas9	negative selection	3495542
197328931	197328954	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	5.270238601174	[]	[]	8	hSpCas9	negative selection	3495543
197421004	197421027	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	CATTGACGTCTTCTTCGCAGTGG	CRB1	ENSG00000134376	-2.01635639839487	[]	[]	-2	hSpCas9	negative selection	3495544
197347354	197347377	1	+	26780180	A375	viability (Avana lentiGuide)	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	-0.359856013770631	[]	[]	0	hSpCas9	negative selection	3604198
197328924	197328947	1	+	26780180	A375	viability (Avana lentiGuide)	TTCAGATCCCTGCAAGAACGAGG	CRB1	ENSG00000134376	1.32853716074398	[]	[]	1	hSpCas9	negative selection	3604199
197328567	197328590	1	-	26780180	A375	viability (Avana lentiGuide)	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	1.94478698750363	[]	[]	2	hSpCas9	negative selection	3604200
197328680	197328703	1	-	26780180	A375	viability (Avana lentiGuide)	GTTCTTGCCACAGGAACCAATGG	CRB1	ENSG00000134376	12.9466601429714	[]	[]	7	hSpCas9	negative selection	3604201
197328931	197328954	1	-	26780180	A375	viability (Avana lentiGuide)	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-6.43714555069197	[]	[]	-9	hSpCas9	negative selection	3604202
197421004	197421027	1	-	26780180	A375	viability (Avana lentiGuide)	CATTGACGTCTTCTTCGCAGTGG	CRB1	ENSG00000134376	16.6561631286925	[]	[]	8	hSpCas9	negative selection	3604203
197347354	197347377	1	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.0330976292949539	[5]	[6,4]	0	hSpCas9	positive selection	3712857
197328924	197328947	1	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTCAGATCCCTGCAAGAACGAGG	CRB1	ENSG00000134376	0.25789940514142434	[5]	[6,5]	7	hSpCas9	positive selection	3712858
197328567	197328590	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.10970630819880636	[5]	[6,5]	3	hSpCas9	positive selection	3712859
197328680	197328703	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTCTTGCCACAGGAACCAATGG	CRB1	ENSG00000134376	0.24011143779337762	[4]	[4,5]	6	hSpCas9	positive selection	3712860
197328931	197328954	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.2856460744922446	[4]	[4,5]	8	hSpCas9	positive selection	3712861
197421004	197421027	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CATTGACGTCTTCTTCGCAGTGG	CRB1	ENSG00000134376	-0.23243006322988083	[5]	[5,3]	-4	hSpCas9	positive selection	3712862
197347354	197347377	1	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.19253743381671337	[6]	[5,6]	5	hSpCas9	positive selection	3821464
197328924	197328947	1	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTCAGATCCCTGCAAGAACGAGG	CRB1	ENSG00000134376	-0.23753742845100895	[4]	[5,1]	-3	hSpCas9	positive selection	3821465
197328567	197328590	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.024032368030627638	[6]	[4,5]	0	hSpCas9	positive selection	3821466
197328680	197328703	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTCTTGCCACAGGAACCAATGG	CRB1	ENSG00000134376	0.03682916054984861	[4]	[2,4]	0	hSpCas9	positive selection	3821467
197328931	197328954	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.46656354820982504	[4]	[5,5]	9	hSpCas9	positive selection	3821468
197421004	197421027	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CATTGACGTCTTCTTCGCAGTGG	CRB1	ENSG00000134376	-0.09582435751939206	[5]	[4,4]	-1	hSpCas9	positive selection	3821469
197328931	197328954	1	-	26780180	A375	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.520517395670168	[]	[]	1	hSpCas9	negative selection	3929488
197328885	197328908	1	+	26780180	A375	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	1.30071534627438	[]	[]	7	hSpCas9	negative selection	3929489
197344336	197344359	1	+	26780180	A375	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	1.19359934613115	[]	[]	6	hSpCas9	negative selection	3929490
197344313	197344336	1	+	26780180	A375	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	1.06237995493456	[]	[]	5	hSpCas9	negative selection	3929491
197328931	197328954	1	-	26780180	HT29	viability (GeCKOv2 library)	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.75270258715049	[]	[]	3	hSpCas9	negative selection	4037454
197328885	197328908	1	+	26780180	HT29	viability (GeCKOv2 library)	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.312078140528397	[]	[]	0	hSpCas9	negative selection	4037455
197344336	197344359	1	+	26780180	HT29	viability (GeCKOv2 library)	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	0.690588194251421	[]	[]	2	hSpCas9	negative selection	4037456
197344313	197344336	1	+	26780180	HT29	viability (GeCKOv2 library)	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	1.18143486529454	[]	[]	6	hSpCas9	negative selection	4037457
197268451	197268474	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AGATAAGCAGTGAGAAACTGAGG	CRB1	ENSG00000134376	-0.2216011086970155	[4]	[2,2]	-5	hSpCas9	positive selection	4129532
197328990	197329013	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CACACTTACCAGAATAATTGTGG	CRB1	ENSG00000134376	0.24978429571339972	[4]	[3,4]	6	hSpCas9	positive selection	4129534
197328931	197328954	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.277418795044443	[5]	[4,4]	7	hSpCas9	positive selection	4129536
197268411	197268434	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GTTAATGTTCTTAAGTGCCATGG	CRB1	ENSG00000134376	-0.06249430169292908	[4]	[2,3]	-1	hSpCas9	positive selection	4129537
197328885	197328908	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.3041418808353771	[5]	[4,5]	7	hSpCas9	positive selection	4129538
197268451	197268474	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AGATAAGCAGTGAGAAACTGAGG	CRB1	ENSG00000134376	0.17049021943497195	[5]	[3,3,2,0]	1	hSpCas9	positive selection	4193554
197328990	197329013	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CACACTTACCAGAATAATTGTGG	CRB1	ENSG00000134376	0.1293157500068582	[4]	[5,2,2,0]	1	hSpCas9	positive selection	4193556
197328931	197328954	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	1.1355626243603059	[5]	[5,4,6,5]	8	hSpCas9	positive selection	4193558
197268411	197268434	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GTTAATGTTCTTAAGTGCCATGG	CRB1	ENSG00000134376	1.016986640463463	[4]	[4,2,3,3]	7	hSpCas9	positive selection	4193559
197328885	197328908	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.8404595187678305	[6]	[5,4,5,3]	5	hSpCas9	positive selection	4193560
197328885	197328908	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.3462059828302128	[4]	[3,1]	-6	hSpCas9	positive selection	4264765
197328931	197328954	1	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.3419020492376399	[3]	[4,3]	7	hSpCas9	positive selection	4264766
197344336	197344359	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.07919016846924404	[4]	[3,2]	-1	hSpCas9	positive selection	4264767
197344313	197344336	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	-0.16429242712043174	[2]	[1,0]	-3	hSpCas9	positive selection	4329035
197328712	197328734	1	+	27760321	OCIAML3	viability	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	0.2049960517364698	[354,255]	[187,382]	2	hSpCas9	negative selection	4391590
197328816	197328838	1	-	27760321	OCIAML3	viability	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	0.6258474358948112	[1001,788]	[959,1221]	7	hSpCas9	negative selection	4391591
197328886	197328908	1	+	27760321	OCIAML3	viability	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.2529793621555807	[512,373]	[299,272]	-3	hSpCas9	negative selection	4391592
197356877	197356899	1	+	27760321	OCIAML3	viability	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	0.2408073279808597	[710,569]	[502,699]	3	hSpCas9	negative selection	4391593
197356924	197356946	1	+	27760321	OCIAML3	viability	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	-1.0650403291661064	[554,480]	[193,191]	-7	hSpCas9	negative selection	4391594
197328712	197328734	1	+	27760321	OCIAML2	viability	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	0.2868665763854076	[354,255]	[310,281]	4	hSpCas9	negative selection	4475053
197328816	197328838	1	-	27760321	OCIAML2	viability	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	0.6799520407470874	[1001,788]	[954,1413]	8	hSpCas9	negative selection	4475054
197328886	197328908	1	+	27760321	OCIAML2	viability	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.0203668231363427	[512,373]	[365,352]	0	hSpCas9	negative selection	4475055
197356877	197356899	1	+	27760321	OCIAML2	viability	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	0.22895099522522733	[710,569]	[513,721]	3	hSpCas9	negative selection	4475056
197356924	197356946	1	+	27760321	OCIAML2	viability	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	-0.4761558878359903	[554,480]	[252,362]	-5	hSpCas9	negative selection	4475057
197328712	197328734	1	+	27760321	MV411	viability	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	0.3160108324349563	[354,255]	[72,511]	2	hSpCas9	negative selection	4558516
197328816	197328838	1	-	27760321	MV411	viability	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	1.5680564148381597	[1001,788]	[2004,1343]	9	hSpCas9	negative selection	4558517
197328886	197328908	1	+	27760321	MV411	viability	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.7443911640465528	[512,373]	[240,852]	5	hSpCas9	negative selection	4558518
197356877	197356899	1	+	27760321	MV411	viability	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	0.6411616772412677	[710,569]	[405,1029]	5	hSpCas9	negative selection	4558519
197356924	197356946	1	+	27760321	MV411	viability	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	0.5311031846892046	[554,480]	[347,709]	4	hSpCas9	negative selection	4558520
197328712	197328734	1	+	27760321	HL60	viability	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	0.47486330750378297	[354,255]	[321,365]	6	hSpCas9	negative selection	4641979
197328816	197328838	1	-	27760321	HL60	viability	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	0.3075848361590081	[1001,788]	[699,1110]	4	hSpCas9	negative selection	4641980
197328886	197328908	1	+	27760321	HL60	viability	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.5977358805096729	[512,373]	[476,612]	7	hSpCas9	negative selection	4641981
197356877	197356899	1	+	27760321	HL60	viability	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	0.6137147721681916	[710,569]	[729,865]	7	hSpCas9	negative selection	4641982
197356924	197356946	1	+	27760321	HL60	viability	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	0.5764290488404844	[554,480]	[590,669]	7	hSpCas9	negative selection	4641983
197328712	197328734	1	+	27760321	HT1080	viability	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	-0.29883769794143156	[255,199]	[80,65]	-1	hSpCas9	negative selection	4725442
197328816	197328838	1	-	27760321	HT1080	viability	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	1.644886716005129	[788,615]	[952,789]	8	hSpCas9	negative selection	4725443
197328886	197328908	1	+	27760321	HT1080	viability	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.08955444897598054	[373,291]	[159,85]	0	hSpCas9	negative selection	4725444
197356877	197356899	1	+	27760321	HT1080	viability	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	1.0455018342634756	[569,444]	[191,663]	5	hSpCas9	negative selection	4725445
197356924	197356946	1	+	27760321	HT1080	viability	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	1.1351632931510116	[480,375]	[268,490]	6	hSpCas9	negative selection	4725446
197328712	197328734	1	+	27760321	HT29	viability after 7 days	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	-0.20029963142807172	[255,199]	[94,319,324]	-3	hSpCas9	negative selection	4808905
197328816	197328838	1	-	27760321	HT29	viability after 7 days	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	0.687323613027829	[788,615]	[1264,1287,1770]	9	hSpCas9	negative selection	4808906
197328886	197328908	1	+	27760321	HT29	viability after 7 days	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.24966782695234985	[373,291]	[719,375,461]	4	hSpCas9	negative selection	4808907
197356877	197356899	1	+	27760321	HT29	viability after 7 days	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	0.6668428139414848	[569,444]	[790,1296,984]	8	hSpCas9	negative selection	4808908
197356924	197356946	1	+	27760321	HT29	viability after 7 days	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	-0.4528641408279369	[480,375]	[461,397,356]	-6	hSpCas9	negative selection	4808909
197328712	197328734	1	+	27760321	HT29	viability after 25 days	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	0.6638830582872493	[255,199]	[283,402,575]	7	hSpCas9	negative selection	4892368
197328816	197328838	1	-	27760321	HT29	viability after 25 days	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	0.894174792520826	[788,615]	[1509,1315,1664]	9	hSpCas9	negative selection	4892369
197328886	197328908	1	+	27760321	HT29	viability after 25 days	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.841603266906406	[373,291]	[467,825,773]	8	hSpCas9	negative selection	4892370
197356877	197356899	1	+	27760321	HT29	viability after 25 days	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	1.05790488175056	[569,444]	[962,1353,1331]	9	hSpCas9	negative selection	4892371
197356924	197356946	1	+	27760321	HT29	viability after 25 days	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	0.18566317383566405	[480,375]	[519,711,426]	1	hSpCas9	negative selection	4892372
197328712	197328734	1	+	27760321	HT29	viability after 22 days	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	0.6035593152070425	[255,199]	[393,378,428]	6	hSpCas9	negative selection	4975831
197328816	197328838	1	-	27760321	HT29	viability after 22 days	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	0.9773010606266231	[788,615]	[1797,1638,1351]	9	hSpCas9	negative selection	4975832
197328886	197328908	1	+	27760321	HT29	viability after 22 days	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.8587441294408259	[373,291]	[802,541,746]	8	hSpCas9	negative selection	4975833
197356877	197356899	1	+	27760321	HT29	viability after 22 days	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	1.0272526002143694	[569,444]	[1123,1191,1273]	9	hSpCas9	negative selection	4975834
197356924	197356946	1	+	27760321	HT29	viability after 22 days	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	-0.17947694387660704	[480,375]	[441,458,410]	-2	hSpCas9	negative selection	4975835
197328712	197328734	1	+	27760321	HT29	viability after 19 days	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	0.5955200969902414	[255,199]	[392,401,386]	6	hSpCas9	negative selection	5059294
197328816	197328838	1	-	27760321	HT29	viability after 19 days	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	1.0490502433039595	[788,615]	[1620,1967,1402]	9	hSpCas9	negative selection	5059295
197328886	197328908	1	+	27760321	HT29	viability after 19 days	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.832902071268637	[373,291]	[620,950,464]	8	hSpCas9	negative selection	5059296
197356877	197356899	1	+	27760321	HT29	viability after 19 days	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	0.8795694947016846	[569,444]	[1414,1204,635]	8	hSpCas9	negative selection	5059297
197356924	197356946	1	+	27760321	HT29	viability after 19 days	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	0.3470904365088115	[480,375]	[474,586,785]	3	hSpCas9	negative selection	5059298
197328712	197328734	1	+	27760321	HT29	viability after 16 days	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	0.7301299523629883	[255,199]	[496,399,379]	8	hSpCas9	negative selection	5142757
197328816	197328838	1	-	27760321	HT29	viability after 16 days	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	1.089026983293694	[788,615]	[1559,2023,1411]	9	hSpCas9	negative selection	5142758
197328886	197328908	1	+	27760321	HT29	viability after 16 days	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.7631727378885645	[373,291]	[814,599,499]	8	hSpCas9	negative selection	5142759
197356877	197356899	1	+	27760321	HT29	viability after 16 days	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	0.8405239657685823	[569,444]	[994,904,1150]	8	hSpCas9	negative selection	5142760
197356924	197356946	1	+	27760321	HT29	viability after 16 days	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	0.18076467779047584	[480,375]	[513,638,471]	2	hSpCas9	negative selection	5142761
197328712	197328734	1	+	27760321	HT29	viability after 13 days	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	0.34977044627511056	[255,199]	[324,361,324]	4	hSpCas9	negative selection	5226220
197328816	197328838	1	-	27760321	HT29	viability after 13 days	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	0.8068811479251369	[788,615]	[1737,1328,1221]	9	hSpCas9	negative selection	5226221
197328886	197328908	1	+	27760321	HT29	viability after 13 days	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.783583994796046	[373,291]	[587,654,746]	8	hSpCas9	negative selection	5226222
197356877	197356899	1	+	27760321	HT29	viability after 13 days	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	0.3914297311184165	[569,444]	[713,611,977]	5	hSpCas9	negative selection	5226223
197356924	197356946	1	+	27760321	HT29	viability after 13 days	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	-0.3893804218683279	[480,375]	[353,427,357]	-4	hSpCas9	negative selection	5226224
197328712	197328734	1	+	27760321	HT29	viability after 10 days	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	0.27402082969558744	[255,199]	[411,400,223]	3	hSpCas9	negative selection	5309683
197328816	197328838	1	-	27760321	HT29	viability after 10 days	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	0.743680222594245	[788,615]	[1131,2022,1270]	8	hSpCas9	negative selection	5309684
197328886	197328908	1	+	27760321	HT29	viability after 10 days	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.33436693726472866	[373,291]	[739,415,415]	4	hSpCas9	negative selection	5309685
197356877	197356899	1	+	27760321	HT29	viability after 10 days	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	0.5859162372896094	[569,444]	[782,1062,1008]	7	hSpCas9	negative selection	5309686
197356924	197356946	1	+	27760321	HT29	viability after 10 days	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	0.02759235088970019	[480,375]	[533,608,495]	0	hSpCas9	negative selection	5309687
197328712	197328734	1	+	27760321	MOLM13	viability	CATGGAGGTATTTGCCATCAGG	CRB1	ENSG00000134376	0.5544637510699847	[354,255]	[255,245]	4	hSpCas9	negative selection	5393146
197328816	197328838	1	-	27760321	MOLM13	viability	CACGGCCCCATTTTGGCAAGGG	CRB1	ENSG00000134376	1.200829373934885	[1001,788]	[1585,785]	8	hSpCas9	negative selection	5393147
197328886	197328908	1	+	27760321	MOLM13	viability	CAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	1.0051228874716296	[512,373]	[464,524]	7	hSpCas9	negative selection	5393148
197356877	197356899	1	+	27760321	MOLM13	viability	TAACCCCTGCCAGTCCAATGGG	CRB1	ENSG00000134376	0.9488250447167647	[710,569]	[914,504]	6	hSpCas9	negative selection	5393149
197356924	197356946	1	+	27760321	MOLM13	viability	AACAATATGGACGCATCACTGG	CRB1	ENSG00000134376	0.02977867446948762	[554,480]	[235,349]	0	hSpCas9	negative selection	5393150
197268288	197268311	1	+	27661255	K562	viability	GTGGGACAGAGATGGCACCTGGG	CRB1	ENSG00000134376	0.08734057489476177	[1021,1171]	[1020,849]	3	dCas9-KRAB	negative selection	5472643
197328885	197328908	1	+	27260156	BXPC3	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.09904739137635565	[1202]	[1159,939,1272,1355]	-2	hSpCas9	negative selection	5537225
197328931	197328954	1	-	27260156	BXPC3	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.03360852072779941	[952]	[1015,992,920,1159]	0	hSpCas9	negative selection	5537226
197344336	197344359	1	+	27260156	BXPC3	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	0.0905450439050588	[1029]	[964,1156,1210,1282]	2	hSpCas9	negative selection	5537227
197344313	197344336	1	+	27260156	BXPC3	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.3365358136307781	[200]	[223,236,259,355]	7	hSpCas9	negative selection	5601495
197328885	197328908	1	+	27260156	A673	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.1420469939268576	[1202]	[1209,1408,1212,1392]	-4	hSpCas9	negative selection	5658476
197328931	197328954	1	-	27260156	A673	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.09050271983887748	[952]	[1359,994,1038,929]	-2	hSpCas9	negative selection	5658477
197344336	197344359	1	+	27260156	A673	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.004080568292727849	[1029]	[1196,1147,1298,1286]	0	hSpCas9	negative selection	5658478
197344313	197344336	1	+	27260156	A673	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.05160416062965001	[200]	[312,218,230,244]	1	hSpCas9	negative selection	5722746
197328885	197328908	1	+	27260156	A375	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.6992742463284619	[1202]	[868,861,845,878]	-7	hSpCas9	negative selection	5779727
197328931	197328954	1	-	27260156	A375	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.3743082820330774	[952]	[1229,1895,1229,1467]	5	hSpCas9	negative selection	5779728
197344336	197344359	1	+	27260156	A375	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.19937142325799084	[1029]	[1101,1165,917,1020]	-3	hSpCas9	negative selection	5779729
197344313	197344336	1	+	27260156	A375	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.9859447980366637	[200]	[616,503,318,428]	9	hSpCas9	negative selection	5843997
197328885	197328908	1	+	27260156	COLO741	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.07503758726651699	[1202]	[1815,1419,1632]	1	hSpCas9	negative selection	5900978
197328931	197328954	1	-	27260156	COLO741	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.015168229328983429	[952]	[1392,1339,987]	0	hSpCas9	negative selection	5900979
197344336	197344359	1	+	27260156	COLO741	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	0.011884586531443642	[1029]	[1303,1234,1428]	0	hSpCas9	negative selection	5900980
197344313	197344336	1	+	27260156	COLO741	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.3127372216348976	[200]	[356,291,310]	6	hSpCas9	negative selection	5965248
197328885	197328908	1	+	27260156	CAL120	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.2445535409961388	[1202]	[1239,1021,1519]	-4	hSpCas9	negative selection	6022229
197328931	197328954	1	-	27260156	CAL120	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.2308412542151428	[952]	[1457,1645,1085]	3	hSpCas9	negative selection	6022230
197344336	197344359	1	+	27260156	CAL120	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.439153481796153	[1029]	[812,1126,876]	-6	hSpCas9	negative selection	6022231
197344313	197344336	1	+	27260156	CAL120	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	-0.11540103809316093	[200]	[208,288,191]	-2	hSpCas9	negative selection	6086499
197328885	197328908	1	+	27260156	CADOES1	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.3434915250166959	[1202]	[877,822,997,825]	-5	hSpCas9	negative selection	6143480
197328931	197328954	1	-	27260156	CADOES1	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.03420801336788648	[952]	[859,931,714,958]	0	hSpCas9	negative selection	6143481
197344336	197344359	1	+	27260156	CADOES1	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.38804082538719964	[1029]	[723,617,698,892]	-6	hSpCas9	negative selection	6143482
197344313	197344336	1	+	27260156	CADOES1	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.44216421690821617	[200]	[230,279,328,172]	7	hSpCas9	negative selection	6207750
197328885	197328908	1	+	27260156	EWS502	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.27013357942627825	[1202]	[927,950,1113,1264]	-5	hSpCas9	negative selection	6264731
197328931	197328954	1	-	27260156	EWS502	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.09854440548701171	[952]	[1179,951,846,1348]	1	hSpCas9	negative selection	6264732
197344336	197344359	1	+	27260156	EWS502	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	0.0068442380973952055	[1029]	[1201,898,932,1357]	0	hSpCas9	negative selection	6264733
197344313	197344336	1	+	27260156	EWS502	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.48482103425355483	[200]	[189,274,324,423]	8	hSpCas9	negative selection	6329001
197328885	197328908	1	+	27260156	EW8	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.057809073642712816	[1202]	[896,1030,912,902]	-1	hSpCas9	negative selection	6385982
197328931	197328954	1	-	27260156	EW8	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.06377804107345553	[952]	[1041,770,660,526]	-1	hSpCas9	negative selection	6385983
197344336	197344359	1	+	27260156	EW8	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	0.08445507738798375	[1029]	[934,893,838,882]	1	hSpCas9	negative selection	6385984
197344313	197344336	1	+	27260156	EW8	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	-0.10484759016110035	[200]	[183,145,175,98]	-2	hSpCas9	negative selection	6450252
197328885	197328908	1	+	27260156	CORL105	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.04318037442409395	[1202]	[1214,1280,1452,1526]	-1	hSpCas9	negative selection	6507233
197328931	197328954	1	-	27260156	CORL105	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.07008864274710391	[952]	[1206,834,1633,1088]	1	hSpCas9	negative selection	6507234
197344336	197344359	1	+	27260156	CORL105	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.13587676683163552	[1029]	[1053,1088,1173,1082]	-3	hSpCas9	negative selection	6507235
197344313	197344336	1	+	27260156	CORL105	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.13001520847683867	[200]	[271,180,315,271]	2	hSpCas9	negative selection	6571503
197328885	197328908	1	+	27260156	HS294T	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.03575353556725691	[1202]	[302,615,500,501]	0	hSpCas9	negative selection	6628484
197328931	197328954	1	-	27260156	HS294T	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.0803182004967542	[952]	[555,277,308,403]	1	hSpCas9	negative selection	6628485
197344336	197344359	1	+	27260156	HS294T	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	0.09306009665216819	[1029]	[282,460,492,482]	1	hSpCas9	negative selection	6628486
197344313	197344336	1	+	27260156	HS294T	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	-0.2088370655177234	[200]	[88,59,49,67]	-3	hSpCas9	negative selection	6692754
197328885	197328908	1	+	27260156	HCC44	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.0672916948967317	[1202]	[1404,1278,1862,1243]	1	hSpCas9	negative selection	6749735
197328931	197328954	1	-	27260156	HCC44	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.14241044190486285	[952]	[657,851,1357,1080]	-2	hSpCas9	negative selection	6749736
197344336	197344359	1	+	27260156	HCC44	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.1350174733751287	[1029]	[1166,815,1428,934]	-2	hSpCas9	negative selection	6749737
197344313	197344336	1	+	27260156	HCC44	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.633642378458794	[200]	[469,225,339,396]	9	hSpCas9	negative selection	6814005
197328885	197328908	1	+	27260156	G402	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.1900664302788646	[1202]	[1065,1264,1369,1401]	-2	hSpCas9	negative selection	6870986
197328931	197328954	1	-	27260156	G402	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.3446068933269224	[952]	[2424,860,1454,1270]	4	hSpCas9	negative selection	6870987
197344336	197344359	1	+	27260156	G402	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	0.05491093406564951	[1029]	[1285,1292,1230,1398]	0	hSpCas9	negative selection	6870988
197344313	197344336	1	+	27260156	G402	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	-0.29539149387857044	[200]	[139,149,358,140]	-4	hSpCas9	negative selection	6935256
197328885	197328908	1	+	27260156	L33	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.10539012512796364	[1202]	[1514,498,719,1291]	2	hSpCas9	negative selection	6992237
197328931	197328954	1	-	27260156	L33	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.03988228047681819	[952]	[835,427,565,928]	-1	hSpCas9	negative selection	6992238
197344336	197344359	1	+	27260156	L33	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	0.00486321993418759	[1029]	[1151,407,638,966]	0	hSpCas9	negative selection	6992239
197344313	197344336	1	+	27260156	L33	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.3512251169194782	[200]	[252,112,151,254]	7	hSpCas9	negative selection	7056507
197328885	197328908	1	+	27260156	K562	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.31291933999949695	[1202]	[774,997,911,760]	-4	hSpCas9	negative selection	7113488
197328931	197328954	1	-	27260156	K562	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.04209495134661001	[952]	[1046,1159,695,633]	0	hSpCas9	negative selection	7113489
197344336	197344359	1	+	27260156	K562	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.20451646581573124	[1029]	[1013,644,662,850]	-3	hSpCas9	negative selection	7113490
197344313	197344336	1	+	27260156	K562	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.6209173033406461	[200]	[509,226,130,247]	7	hSpCas9	negative selection	7177758
197328885	197328908	1	+	27260156	HT29	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.14283543527924802	[1202]	[1393,1275,1432,1201]	-3	hSpCas9	negative selection	7234739
197328931	197328954	1	-	27260156	HT29	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.10739483942947636	[952]	[1468,1335,1129,1091]	2	hSpCas9	negative selection	7234740
197344336	197344359	1	+	27260156	HT29	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.09276057494124768	[1029]	[1312,1017,1133,1214]	-2	hSpCas9	negative selection	7234741
197344313	197344336	1	+	27260156	HT29	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.37105219334454476	[200]	[323,367,215,353]	7	hSpCas9	negative selection	7299009
197328885	197328908	1	+	27260156	MHHES1	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.09333083757011207	[1202]	[1289,1269,1381,1141]	-2	hSpCas9	negative selection	7355990
197328931	197328954	1	-	27260156	MHHES1	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.1641508139337211	[952]	[1395,1201,1334,936]	3	hSpCas9	negative selection	7355991
197344336	197344359	1	+	27260156	MHHES1	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.2782483590988726	[1029]	[908,813,1035,1011]	-5	hSpCas9	negative selection	7355992
197344313	197344336	1	+	27260156	MHHES1	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.31108528282020487	[200]	[222,238,316,317]	5	hSpCas9	negative selection	7420260
197328885	197328908	1	+	27260156	MEWO	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.19659548365955182	[1202]	[965,975,1000]	-4	hSpCas9	negative selection	7477241
197328931	197328954	1	-	27260156	MEWO	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.13194106792036497	[952]	[1160,845,959]	3	hSpCas9	negative selection	7477242
197344336	197344359	1	+	27260156	MEWO	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.002841678755101107	[1029]	[1137,783,997]	0	hSpCas9	negative selection	7477243
197344313	197344336	1	+	27260156	MEWO	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.3650174362783196	[200]	[274,213,243]	7	hSpCas9	negative selection	7541511
197328885	197328908	1	+	27260156	LNCAPCLONEFGC	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.4951387012413839	[1202]	[817,533,994,792]	-6	hSpCas9	negative selection	7598492
197328931	197328954	1	-	27260156	LNCAPCLONEFGC	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.09344704684700522	[952]	[892,946,1032,825]	1	hSpCas9	negative selection	7598493
197344336	197344359	1	+	27260156	LNCAPCLONEFGC	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.05582237600488882	[1029]	[929,816,940,912]	-1	hSpCas9	negative selection	7598494
197344313	197344336	1	+	27260156	LNCAPCLONEFGC	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.9035283236803298	[200]	[392,290,485,215]	9	hSpCas9	negative selection	7662762
197328885	197328908	1	+	27260156	PANC0327	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.04177163336076517	[1202]	[1137,1055,956,1006]	0	hSpCas9	negative selection	7719743
197328931	197328954	1	-	27260156	PANC0327	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.24256737524003114	[952]	[713,452,914,813]	-4	hSpCas9	negative selection	7719744
197344336	197344359	1	+	27260156	PANC0327	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.14085260126328036	[1029]	[677,899,996,722]	-2	hSpCas9	negative selection	7719745
197344313	197344336	1	+	27260156	PANC0327	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.37492936651172226	[200]	[204,345,144,212]	5	hSpCas9	negative selection	7784013
197328885	197328908	1	+	27260156	NCIH2009	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.0370942804024017	[1202]	[1922,1575,1469]	0	hSpCas9	negative selection	7840994
197328931	197328954	1	-	27260156	NCIH2009	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.33210462769159865	[952]	[1920,1454,1701]	4	hSpCas9	negative selection	7840995
197344336	197344359	1	+	27260156	NCIH2009	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.11794459679483182	[1029]	[1585,1459,978]	-2	hSpCas9	negative selection	7840996
197344313	197344336	1	+	27260156	NCIH2009	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.1084433238505853	[200]	[326,276,308]	1	hSpCas9	negative selection	7905264
197328885	197328908	1	+	27260156	NCIH1373	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.3894280330173193	[1202]	[1276,855,991,274]	-4	hSpCas9	negative selection	7962245
197328931	197328954	1	-	27260156	NCIH1373	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.18381380836639716	[952]	[1694,1133,988,291]	1	hSpCas9	negative selection	7962246
197344336	197344359	1	+	27260156	NCIH1373	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.16849480993847987	[1029]	[907,606,1411,316]	-2	hSpCas9	negative selection	7962247
197344313	197344336	1	+	27260156	NCIH1373	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.8104316396386793	[200]	[301,747,183,75]	7	hSpCas9	negative selection	8026515
197328885	197328908	1	+	27260156	PATU8902	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.34444609037847806	[1202]	[1812,1094,879,1622]	-3	hSpCas9	negative selection	8083496
197328931	197328954	1	-	27260156	PATU8902	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.14349219110306843	[952]	[1839,1190,1186,1732]	1	hSpCas9	negative selection	8083497
197344336	197344359	1	+	27260156	PATU8902	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.02896824128822595	[1029]	[1376,1410,1279,1600]	0	hSpCas9	negative selection	8083498
197344313	197344336	1	+	27260156	PATU8902	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.791641139631345	[200]	[700,210,241,887]	8	hSpCas9	negative selection	8147766
197328885	197328908	1	+	27260156	PANC1	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.189627412038186	[1202]	[1149,1580,1198,894]	3	hSpCas9	negative selection	8204747
197328931	197328954	1	-	27260156	PANC1	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.37276528825031185	[952]	[740,1446,1045,1071]	6	hSpCas9	negative selection	8204748
197344336	197344359	1	+	27260156	PANC1	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	0.20105082425919085	[1029]	[916,1635,859,801]	3	hSpCas9	negative selection	8204749
197344313	197344336	1	+	27260156	PANC1	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	-0.33685581772658035	[200]	[199,193,56,107]	-5	hSpCas9	negative selection	8269017
197328885	197328908	1	+	27260156	PANC0813	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.08155011910693011	[1202]	[1545,1159,1613,1654]	1	hSpCas9	negative selection	8325998
197328931	197328954	1	-	27260156	PANC0813	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.06169398054745501	[952]	[1299,985,1160,1232]	1	hSpCas9	negative selection	8325999
197344336	197344359	1	+	27260156	PANC0813	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.03123203765474014	[1029]	[1553,1154,1102,967]	0	hSpCas9	negative selection	8326000
197344313	197344336	1	+	27260156	PANC0813	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.24578890864267444	[200]	[452,316,214,156]	4	hSpCas9	negative selection	8390268
197328885	197328908	1	+	27260156	RDES	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.324075657324733	[1202]	[930,1049,1237,1234]	-5	hSpCas9	negative selection	8447249
197328931	197328954	1	-	27260156	RDES	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.06805405251925589	[952]	[756,1002,1155,1353]	-1	hSpCas9	negative selection	8447250
197344336	197344359	1	+	27260156	RDES	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.14117297953851882	[1029]	[806,1077,1157,1319]	-2	hSpCas9	negative selection	8447251
197344313	197344336	1	+	27260156	RDES	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.717628188174751	[200]	[292,405,286,563]	9	hSpCas9	negative selection	8511519
197328885	197328908	1	+	27260156	PC3	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.014243104596221468	[1202]	[779,1104,2028,1227]	0	hSpCas9	negative selection	8568500
197328931	197328954	1	-	27260156	PC3	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.03913684794050709	[952]	[536,859,1690,1001]	-1	hSpCas9	negative selection	8568501
197344336	197344359	1	+	27260156	PC3	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	0.14285762976905692	[1029]	[516,1041,2253,1360]	3	hSpCas9	negative selection	8568502
197344313	197344336	1	+	27260156	PC3	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	-0.06191096124505058	[200]	[168,153,313,163]	-1	hSpCas9	negative selection	8632770
197328885	197328908	1	+	27260156	PATU8988T	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.35661291038550313	[1202]	[584,1074,1072,911]	-5	hSpCas9	negative selection	8689751
197328931	197328954	1	-	27260156	PATU8988T	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.11689728694790458	[952]	[1860,727,520,853]	2	hSpCas9	negative selection	8689752
197344336	197344359	1	+	27260156	PATU8988T	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	0.07205981745998624	[1029]	[1071,847,1238,1000]	1	hSpCas9	negative selection	8689753
197344313	197344336	1	+	27260156	PATU8988T	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.44695994767278646	[200]	[273,327,216,244]	7	hSpCas9	negative selection	8754021
197328885	197328908	1	+	27260156	T47D	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.2684110221447795	[1202]	[1204,912,1273,1285]	-5	hSpCas9	negative selection	8811002
197328931	197328954	1	-	27260156	T47D	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.11187636634836196	[952]	[1312,1006,1139,1361]	2	hSpCas9	negative selection	8811003
197344336	197344359	1	+	27260156	T47D	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.18918663927914892	[1029]	[968,1018,1112,1111]	-4	hSpCas9	negative selection	8811004
197344313	197344336	1	+	27260156	T47D	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.03114462500677795	[200]	[239,198,237,284]	0	hSpCas9	negative selection	8875272
197328885	197328908	1	+	27260156	SU8686	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	0.2571933694615718	[1202]	[1346,1356,1548,1465]	4	hSpCas9	negative selection	8932253
197328931	197328954	1	-	27260156	SU8686	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	0.14429931967735032	[952]	[913,878,1276,1160]	2	hSpCas9	negative selection	8932254
197344336	197344359	1	+	27260156	SU8686	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.06254630988337473	[1029]	[802,833,1013,1353]	-1	hSpCas9	negative selection	8932255
197344313	197344336	1	+	27260156	SU8686	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.4809729754908283	[200]	[311,183,344,279]	7	hSpCas9	negative selection	8996523
197328885	197328908	1	+	27260156	SKES1	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.0072585339901998225	[1202]	[1315,1403,1118,991]	0	hSpCas9	negative selection	9053504
197328931	197328954	1	-	27260156	SKES1	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.041692732463028404	[952]	[1128,838,1038,718]	-1	hSpCas9	negative selection	9053505
197344336	197344359	1	+	27260156	SKES1	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.06548974562345933	[1029]	[1126,985,891,938]	-1	hSpCas9	negative selection	9053506
197344313	197344336	1	+	27260156	SKES1	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.38427610949051094	[200]	[152,446,250,206]	7	hSpCas9	negative selection	9117774
197328885	197328908	1	+	27260156	TOV112D	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.051748207464767715	[1202]	[913,1507,1313,980]	-1	hSpCas9	negative selection	9174755
197328931	197328954	1	-	27260156	TOV112D	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.042804755355938195	[952]	[759,1163,928,896]	-1	hSpCas9	negative selection	9174756
197344336	197344359	1	+	27260156	TOV112D	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.017140528692940027	[1029]	[1168,1474,838,725]	0	hSpCas9	negative selection	9174757
197344313	197344336	1	+	27260156	TOV112D	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	0.3357953310340528	[200]	[385,214,221,195]	6	hSpCas9	negative selection	9239025
197328885	197328908	1	+	27260156	TC71	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.027012281295005325	[1202]	[1181,1317,1229,1339]	0	hSpCas9	negative selection	9296006
197328931	197328954	1	-	27260156	TC71	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.02582460407222742	[952]	[1079,885,1077,962]	0	hSpCas9	negative selection	9296007
197344336	197344359	1	+	27260156	TC71	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	0.09837181629498493	[1029]	[1095,1226,1118,1296]	2	hSpCas9	negative selection	9296008
197344313	197344336	1	+	27260156	TC71	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	-0.06279134289435362	[200]	[204,156,190,276]	-1	hSpCas9	negative selection	9360276
197328885	197328908	1	+	27260156	TC32	viability	TCAAGGCAGACACTGCGACTTGG	CRB1	ENSG00000134376	-0.7273389626447535	[1202]	[464,431,1036,960]	-8	hSpCas9	negative selection	9417257
197328931	197328954	1	-	27260156	TC32	viability	CATGTAGCCTCGTTCTTGCAGGG	CRB1	ENSG00000134376	-0.191793578054962	[952]	[852,399,1195,855]	-3	hSpCas9	negative selection	9417258
197344336	197344359	1	+	27260156	TC32	viability	TGCAACTTGTCAGGATGCTCTGG	CRB1	ENSG00000134376	-0.3986940100676032	[1029]	[630,577,898,894]	-6	hSpCas9	negative selection	9417259
197344313	197344336	1	+	27260156	TC32	viability	TGGTCCCAGCCTTGTTTAAATGG	CRB1	ENSG00000134376	-0.35837276907120286	[200]	[142,92,176,196]	-6	hSpCas9	negative selection	9481527
197328759	197328782	1	-	27869803	HPAFII	viability after 27 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.6252424382178375	[388]	[399,244,NaN]	5	hSpCas9	negative selection	9531183
197347354	197347377	1	+	27869803	HPAFII	viability after 27 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.10015990926399365	[180]	[119,86,NaN]	0	hSpCas9	negative selection	9531184
197356844	197356867	1	-	27869803	HPAFII	viability after 27 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-1.2185435519465762	[234]	[57,48,NaN]	-7	hSpCas9	negative selection	9531185
197421242	197421265	1	-	27869803	HPAFII	viability after 27 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	2.6090739654581663	[66]	[35,363,NaN]	9	hSpCas9	negative selection	9531186
197427612	197427635	1	+	27869803	HPAFII	viability after 27 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	0.031007149752698332	[284]	[211,103,NaN]	0	hSpCas9	negative selection	9531187
197429052	197429075	1	+	27869803	HPAFII	viability after 27 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.5084704187555528	[343]	[217,289,NaN]	4	hSpCas9	negative selection	9531188
197328759	197328782	1	-	27869803	HPAFII	viability after 15 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.10427043229710065	[388]	[671,310,NaN]	1	hSpCas9	negative selection	9613632
197347354	197347377	1	+	27869803	HPAFII	viability after 15 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.2398734279680698	[180]	[373,139,NaN]	2	hSpCas9	negative selection	9613633
197356844	197356867	1	-	27869803	HPAFII	viability after 15 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-0.1530222774511507	[234]	[347,151,NaN]	-2	hSpCas9	negative selection	9613634
197421242	197421265	1	-	27869803	HPAFII	viability after 15 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	1.1649006804350746	[66]	[10,254,NaN]	9	hSpCas9	negative selection	9613635
197427612	197427635	1	+	27869803	HPAFII	viability after 15 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	0.4642624690615912	[284]	[482,384,NaN]	5	hSpCas9	negative selection	9613636
197429052	197429075	1	+	27869803	HPAFII	viability after 15 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.6430452220653937	[343]	[675,515,NaN]	7	hSpCas9	negative selection	9613637
197328759	197328782	1	-	27869803	ASPC1	viability after 36 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	-0.6570191756195845	[779]	[255,181,104]	-6	hSpCas9	negative selection	9696081
197347354	197347377	1	+	27869803	ASPC1	viability after 36 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.3733541185547221	[535]	[486,64,208]	4	hSpCas9	negative selection	9696082
197356844	197356867	1	-	27869803	ASPC1	viability after 36 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-0.3352233233721292	[709]	[324,265,48]	-3	hSpCas9	negative selection	9696083
197421242	197421265	1	-	27869803	ASPC1	viability after 36 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	-0.46824494328459476	[215]	[28,115,22]	-5	hSpCas9	negative selection	9696084
197427612	197427635	1	+	27869803	ASPC1	viability after 36 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	0.20896685129741094	[779]	[243,218,436]	2	hSpCas9	negative selection	9696085
197429052	197429075	1	+	27869803	ASPC1	viability after 36 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.8627319620187928	[1057]	[459,1148,433]	8	hSpCas9	negative selection	9696086
197328759	197328782	1	-	27869803	PATU8988S	viability after 35 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.5424871550468453	[572]	[388,282,NaN]	6	hSpCas9	negative selection	9778530
197347354	197347377	1	+	27869803	PATU8988S	viability after 35 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	0.26908228076700935	[598]	[383,196,NaN]	3	hSpCas9	negative selection	9778531
197356844	197356867	1	-	27869803	PATU8988S	viability after 35 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-0.4229497513400353	[500]	[152,147,NaN]	-4	hSpCas9	negative selection	9778532
197421242	197421265	1	-	27869803	PATU8988S	viability after 35 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	0.097595277636493	[175]	[7,143,NaN]	1	hSpCas9	negative selection	9778533
197427612	197427635	1	+	27869803	PATU8988S	viability after 35 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	0.6007250786068374	[537]	[367,288,NaN]	6	hSpCas9	negative selection	9778534
197429052	197429075	1	+	27869803	PATU8988S	viability after 35 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.19126864714222636	[982]	[464,438,NaN]	2	hSpCas9	negative selection	9778535
197328759	197328782	1	-	27869803	PATU8988S	viability after 31 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.5409173890535276	[572]	[404,239,NaN]	6	hSpCas9	negative selection	9860979
197347354	197347377	1	+	27869803	PATU8988S	viability after 31 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	-0.011381208433515907	[598]	[287,171,NaN]	0	hSpCas9	negative selection	9860980
197356844	197356867	1	-	27869803	PATU8988S	viability after 31 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-0.26680548200291254	[500]	[169,160,NaN]	-3	hSpCas9	negative selection	9860981
197421242	197421265	1	-	27869803	PATU8988S	viability after 31 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	-0.3424145980762978	[175]	[13,107,NaN]	-4	hSpCas9	negative selection	9860982
197427612	197427635	1	+	27869803	PATU8988S	viability after 31 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	0.9107687712585332	[537]	[379,432,NaN]	8	hSpCas9	negative selection	9860983
197429052	197429075	1	+	27869803	PATU8988S	viability after 31 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.40796983103062445	[982]	[450,607,NaN]	5	hSpCas9	negative selection	9860984
197328759	197328782	1	-	27869803	HPAFII	viability after 35 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.7314171985184698	[388]	[357,291,NaN]	5	hSpCas9	negative selection	9943428
197347354	197347377	1	+	27869803	HPAFII	viability after 35 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	-0.8221507696813818	[180]	[56,45,NaN]	-5	hSpCas9	negative selection	9943429
197356844	197356867	1	-	27869803	HPAFII	viability after 35 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-1.4900777386987245	[234]	[39,44,NaN]	-7	hSpCas9	negative selection	9943430
197421242	197421265	1	-	27869803	HPAFII	viability after 35 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	3.21645592712344	[66]	[33,631,NaN]	9	hSpCas9	negative selection	9943431
197427612	197427635	1	+	27869803	HPAFII	viability after 35 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	0.22131790013313826	[284]	[218,110,NaN]	1	hSpCas9	negative selection	9943432
197429052	197429075	1	+	27869803	HPAFII	viability after 35 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.3742354634819153	[343]	[141,319,NaN]	2	hSpCas9	negative selection	9943433
197328759	197328782	1	-	27869803	HPAFII	viability after 31 days	ATCTTCCAGCATATCCAGCAGGG	CRB1	ENSG00000134376	0.8076052397250079	[388]	[473,281,NaN]	6	hSpCas9	negative selection	10025877
197347354	197347377	1	+	27869803	HPAFII	viability after 31 days	GCACGGGTAGTGGATTCACAGGG	CRB1	ENSG00000134376	-0.22128243555390692	[180]	[78,95,NaN]	-1	hSpCas9	negative selection	10025878
197356844	197356867	1	-	27869803	HPAFII	viability after 31 days	CATTGAGGTCGATCTCACACTGG	CRB1	ENSG00000134376	-0.9145989866797591	[234]	[57,82,NaN]	-5	hSpCas9	negative selection	10025879
197421242	197421265	1	-	27869803	HPAFII	viability after 31 days	AGGGACCCGGTGTAGCCAGATGG	CRB1	ENSG00000134376	2.5233140533218945	[66]	[18,430,NaN]	9	hSpCas9	negative selection	10025880
197427612	197427635	1	+	27869803	HPAFII	viability after 31 days	ATCCGTGTCTGGCTAGAGCGCGG	CRB1	ENSG00000134376	-0.30106218262749374	[284]	[136,121,NaN]	-2	hSpCas9	negative selection	10025881
197429052	197429075	1	+	27869803	HPAFII	viability after 31 days	TGTGTAGGATCTTGGGCAACTGG	CRB1	ENSG00000134376	0.819192338471648	[343]	[231,458,NaN]	6	hSpCas9	negative selection	10025882
197328567	197328590	1	-	28162770	P31FUJ	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.06024477048585497	[332]	[407]	0	hSpCas9	negative selection	10137806
197421564	197421587	1	-	28162770	P31FUJ	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.4109902184244527	[904]	[1413]	4	hSpCas9	negative selection	10137807
197328697	197328720	1	+	28162770	P31FUJ	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	-0.050352893577871205	[496]	[563]	0	hSpCas9	negative selection	10137808
197356975	197356998	1	-	28162770	P31FUJ	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	0.16172963942982388	[371]	[488]	1	hSpCas9	negative selection	10137809
197421319	197421342	1	+	28162770	P31FUJ	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	-0.007928793574175863	[414]	[484]	0	hSpCas9	negative selection	10137810
197421361	197421384	1	-	28162770	P31FUJ	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	0.4294254226334805	[102]	[162]	5	hSpCas9	negative selection	10137811
197421500	197421523	1	+	28162770	P31FUJ	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	-0.38550546532810415	[228]	[205]	-3	hSpCas9	negative selection	10137812
197421535	197421558	1	+	28162770	P31FUJ	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	-0.0017030877270316075	[235]	[276]	0	hSpCas9	negative selection	10137813
197328891	197328914	1	+	28162770	P31FUJ	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.32589761149317575	[424]	[625]	3	hSpCas9	negative selection	10137814
197328567	197328590	1	-	28162770	TF1	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	NaN	[NaN]	[138]	1	hSpCas9	negative selection	10307172
197421564	197421587	1	-	28162770	TF1	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	NaN	[NaN]	[1013]	1	hSpCas9	negative selection	10307173
197328697	197328720	1	+	28162770	TF1	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	NaN	[NaN]	[398]	1	hSpCas9	negative selection	10307174
197356975	197356998	1	-	28162770	TF1	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	NaN	[NaN]	[378]	1	hSpCas9	negative selection	10307175
197421319	197421342	1	+	28162770	TF1	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	NaN	[NaN]	[389]	1	hSpCas9	negative selection	10307176
197421361	197421384	1	-	28162770	TF1	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	NaN	[NaN]	[83]	1	hSpCas9	negative selection	10307177
197421500	197421523	1	+	28162770	TF1	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	NaN	[NaN]	[269]	1	hSpCas9	negative selection	10307178
197421535	197421558	1	+	28162770	TF1	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	NaN	[NaN]	[204]	1	hSpCas9	negative selection	10307179
197328891	197328914	1	+	28162770	TF1	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	NaN	[NaN]	[589]	1	hSpCas9	negative selection	10307180
197328567	197328590	1	-	28162770	SKM1	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.5344836189017252	[65]	[168]	5	hSpCas9	negative selection	10476538
197421564	197421587	1	-	28162770	SKM1	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.32108525792508935	[210]	[465]	3	hSpCas9	negative selection	10476539
197328697	197328720	1	+	28162770	SKM1	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.3072813189229606	[143]	[314]	3	hSpCas9	negative selection	10476540
197356975	197356998	1	-	28162770	SKM1	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	0.47590316765884055	[108]	[267]	4	hSpCas9	negative selection	10476541
197421319	197421342	1	+	28162770	SKM1	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	0.1423743922472731	[122]	[239]	1	hSpCas9	negative selection	10476542
197421361	197421384	1	-	28162770	SKM1	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	0.6667454874398475	[30]	[86]	6	hSpCas9	negative selection	10476543
197421500	197421523	1	+	28162770	SKM1	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	-0.06300979752580049	[38]	[65]	0	hSpCas9	negative selection	10476544
197421535	197421558	1	+	28162770	SKM1	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	0.510194732319184	[55]	[140]	5	hSpCas9	negative selection	10476545
197328891	197328914	1	+	28162770	SKM1	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.31089257247533975	[113]	[249]	3	hSpCas9	negative selection	10476546
197328567	197328590	1	-	28162770	SKM1	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.5344836189017252	[65]	[168]	5	hSpCas9	negative selection	10645904
197421564	197421587	1	-	28162770	SKM1	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.32108525792508935	[210]	[465]	3	hSpCas9	negative selection	10645905
197328697	197328720	1	+	28162770	SKM1	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.3072813189229606	[143]	[314]	3	hSpCas9	negative selection	10645906
197356975	197356998	1	-	28162770	SKM1	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	0.47590316765884055	[108]	[267]	4	hSpCas9	negative selection	10645907
197421319	197421342	1	+	28162770	SKM1	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	0.1423743922472731	[122]	[239]	1	hSpCas9	negative selection	10645908
197421361	197421384	1	-	28162770	SKM1	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	0.6667454874398475	[30]	[86]	6	hSpCas9	negative selection	10645909
197421500	197421523	1	+	28162770	SKM1	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	-0.06300979752580049	[38]	[65]	0	hSpCas9	negative selection	10645910
197421535	197421558	1	+	28162770	SKM1	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	0.510194732319184	[55]	[140]	5	hSpCas9	negative selection	10645911
197328891	197328914	1	+	28162770	SKM1	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.31089257247533975	[113]	[249]	3	hSpCas9	negative selection	10645912
197328567	197328590	1	-	28162770	PL21	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.10807906150055246	[274]	[128]	1	hSpCas9	negative selection	10815270
197421564	197421587	1	-	28162770	PL21	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	-0.21999961543369406	[660]	[246]	-1	hSpCas9	negative selection	10815271
197328697	197328720	1	+	28162770	PL21	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.29824969993916794	[539]	[288]	2	hSpCas9	negative selection	10815272
197356975	197356998	1	-	28162770	PL21	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	0.6842614257036487	[315]	[220]	6	hSpCas9	negative selection	10815273
197421319	197421342	1	+	28162770	PL21	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	-0.475638049417503	[376]	[117]	-3	hSpCas9	negative selection	10815274
197421361	197421384	1	-	28162770	PL21	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	0.7026399550185034	[95]	[67]	6	hSpCas9	negative selection	10815275
197421500	197421523	1	+	28162770	PL21	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	0.5062427422149998	[164]	[101]	4	hSpCas9	negative selection	10815276
197421535	197421558	1	+	28162770	PL21	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	-0.579734571146177	[181]	[52]	-4	hSpCas9	negative selection	10815277
197328891	197328914	1	+	28162770	PL21	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.8338174002435041	[329]	[255]	7	hSpCas9	negative selection	10815278
197328567	197328590	1	-	28162770	P31FUJ	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.06024477048585497	[332]	[407]	0	hSpCas9	negative selection	10984636
197421564	197421587	1	-	28162770	P31FUJ	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.4109902184244527	[904]	[1413]	4	hSpCas9	negative selection	10984637
197328697	197328720	1	+	28162770	P31FUJ	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	-0.050352893577871205	[496]	[563]	0	hSpCas9	negative selection	10984638
197356975	197356998	1	-	28162770	P31FUJ	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	0.16172963942982388	[371]	[488]	1	hSpCas9	negative selection	10984639
197421319	197421342	1	+	28162770	P31FUJ	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	-0.007928793574175863	[414]	[484]	0	hSpCas9	negative selection	10984640
197421361	197421384	1	-	28162770	P31FUJ	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	0.4294254226334805	[102]	[162]	5	hSpCas9	negative selection	10984641
197421500	197421523	1	+	28162770	P31FUJ	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	-0.38550546532810415	[228]	[205]	-3	hSpCas9	negative selection	10984642
197421535	197421558	1	+	28162770	P31FUJ	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	-0.0017030877270316075	[235]	[276]	0	hSpCas9	negative selection	10984643
197328891	197328914	1	+	28162770	P31FUJ	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.32589761149317575	[424]	[625]	3	hSpCas9	negative selection	10984644
197328567	197328590	1	-	28162770	OCIAML5	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	-0.6373277220709843	[161]	[187]	-4	hSpCas9	negative selection	11154002
197421564	197421587	1	-	28162770	OCIAML5	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.2760035876313194	[543]	[1188]	2	hSpCas9	negative selection	11154003
197328697	197328720	1	+	28162770	OCIAML5	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.6368492423861247	[294]	[827]	5	hSpCas9	negative selection	11154004
197356975	197356998	1	-	28162770	OCIAML5	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	1.1959895704805064	[154]	[640]	8	hSpCas9	negative selection	11154005
197421319	197421342	1	+	28162770	OCIAML5	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	0.700072082885674	[162]	[477]	6	hSpCas9	negative selection	11154006
197421361	197421384	1	-	28162770	OCIAML5	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	0.3178584305783153	[47]	[107]	2	hSpCas9	negative selection	11154007
197421500	197421523	1	+	28162770	OCIAML5	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	0.4135235398735534	[93]	[225]	3	hSpCas9	negative selection	11154008
197421535	197421558	1	+	28162770	OCIAML5	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	-0.57585677628247	[108]	[131]	-4	hSpCas9	negative selection	11154009
197328891	197328914	1	+	28162770	OCIAML5	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.38059418592627803	[279]	[657]	3	hSpCas9	negative selection	11154010
197328567	197328590	1	-	28162770	EOL1	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	-0.18063446512152181	[511]	[237]	-1	hSpCas9	negative selection	11323368
197421564	197421587	1	-	28162770	EOL1	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.8236860914548663	[932]	[869]	7	hSpCas9	negative selection	11323369
197328697	197328720	1	+	28162770	EOL1	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.5004933989342573	[855]	[637]	4	hSpCas9	negative selection	11323370
197356975	197356998	1	-	28162770	EOL1	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	1.4492360998702325	[667]	[960]	9	hSpCas9	negative selection	11323371
197421319	197421342	1	+	28162770	EOL1	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	-0.40361997795281335	[810]	[322]	-3	hSpCas9	negative selection	11323372
197421361	197421384	1	-	28162770	EOL1	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	-0.5100804560661901	[172]	[63]	-4	hSpCas9	negative selection	11323373
197421500	197421523	1	+	28162770	EOL1	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	-0.05199325560547652	[182]	[92]	0	hSpCas9	negative selection	11323374
197421535	197421558	1	+	28162770	EOL1	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	1.053377751915487	[181]	[198]	8	hSpCas9	negative selection	11323375
197328891	197328914	1	+	28162770	EOL1	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	-0.1782308256069015	[508]	[236]	-1	hSpCas9	negative selection	11323376
197328567	197328590	1	-	28162770	MOLM13	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.22937729484485395	[314]	[266]	1	hSpCas9	negative selection	11492734
197421564	197421587	1	-	28162770	MOLM13	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.9286663098548671	[876]	[1206]	7	hSpCas9	negative selection	11492735
197328697	197328720	1	+	28162770	MOLM13	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.40625031575219284	[788]	[755]	3	hSpCas9	negative selection	11492736
197356975	197356998	1	-	28162770	MOLM13	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	1.1124087269461895	[608]	[951]	8	hSpCas9	negative selection	11492737
197421319	197421342	1	+	28162770	MOLM13	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	0.8990249617188188	[556]	[750]	7	hSpCas9	negative selection	11492738
197421361	197421384	1	-	28162770	MOLM13	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	0.21154962828479307	[128]	[107]	1	hSpCas9	negative selection	11492739
197421500	197421523	1	+	28162770	MOLM13	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	0.7908224886919423	[286]	[358]	6	hSpCas9	negative selection	11492740
197421535	197421558	1	+	28162770	MOLM13	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	0.8704359366402257	[173]	[229]	6	hSpCas9	negative selection	11492741
197328891	197328914	1	+	28162770	MOLM13	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.24722267218529548	[556]	[477]	1	hSpCas9	negative selection	11492742
197328567	197328590	1	-	28162770	HEL	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.03439340384125	[310]	[203]	0	hSpCas9	negative selection	11662100
197421564	197421587	1	-	28162770	HEL	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.2738132575758254	[779]	[603]	2	hSpCas9	negative selection	11662101
197328697	197328720	1	+	28162770	HEL	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.8725695850006594	[607]	[712]	7	hSpCas9	negative selection	11662102
197356975	197356998	1	-	28162770	HEL	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	0.38677780844134935	[528]	[442]	3	hSpCas9	negative selection	11662103
197421319	197421342	1	+	28162770	HEL	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	0.030370173938548906	[557]	[364]	0	hSpCas9	negative selection	11662104
197421361	197421384	1	-	28162770	HEL	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	0.2823365892983587	[94]	[73]	2	hSpCas9	negative selection	11662105
197421500	197421523	1	+	28162770	HEL	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	-0.3769794026141482	[220]	[108]	-3	hSpCas9	negative selection	11662106
197421535	197421558	1	+	28162770	HEL	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	0.30063285517536437	[179]	[141]	2	hSpCas9	negative selection	11662107
197328891	197328914	1	+	28162770	HEL	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.09243281335488673	[472]	[322]	0	hSpCas9	negative selection	11662108
197328567	197328590	1	-	28162770	MV411	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	-0.46603969046106086	[263]	[160]	-3	hSpCas9	negative selection	11831466
197421564	197421587	1	-	28162770	MV411	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.4882790092189997	[665]	[786]	4	hSpCas9	negative selection	11831467
197328697	197328720	1	+	28162770	MV411	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.26492497751161626	[409]	[414]	2	hSpCas9	negative selection	11831468
197356975	197356998	1	-	28162770	MV411	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	0.49319396518473346	[349]	[414]	4	hSpCas9	negative selection	11831469
197421319	197421342	1	+	28162770	MV411	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	-0.6428585297914943	[442]	[238]	-4	hSpCas9	negative selection	11831470
197421361	197421384	1	-	28162770	MV411	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	0.49255004861930674	[80]	[95]	4	hSpCas9	negative selection	11831471
197421500	197421523	1	+	28162770	MV411	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	0.21472197563939704	[222]	[217]	1	hSpCas9	negative selection	11831472
197421535	197421558	1	+	28162770	MV411	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	0.25702359961197346	[149]	[150]	2	hSpCas9	negative selection	11831473
197328891	197328914	1	+	28162770	MV411	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.4989763177787395	[356]	[424]	4	hSpCas9	negative selection	11831474
197328567	197328590	1	-	28162770	MONOMAC1	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.9162627170550124	[152]	[330]	8	hSpCas9	negative selection	12000832
197421564	197421587	1	-	28162770	MONOMAC1	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.15172743280012435	[489]	[623]	1	hSpCas9	negative selection	12000833
197328697	197328720	1	+	28162770	MONOMAC1	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.25547535763795315	[284]	[389]	2	hSpCas9	negative selection	12000834
197356975	197356998	1	-	28162770	MONOMAC1	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	1.4281895238753295	[211]	[653]	9	hSpCas9	negative selection	12000835
197421319	197421342	1	+	28162770	MONOMAC1	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	0.4169341007317493	[278]	[426]	4	hSpCas9	negative selection	12000836
197421361	197421384	1	-	28162770	MONOMAC1	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	-1.1425890630371773	[51]	[26]	-7	hSpCas9	negative selection	12000837
197421500	197421523	1	+	28162770	MONOMAC1	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	0.5301972090888789	[118]	[196]	5	hSpCas9	negative selection	12000838
197421535	197421558	1	+	28162770	MONOMAC1	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	-0.30806815944829746	[107]	[99]	-3	hSpCas9	negative selection	12000839
197328891	197328914	1	+	28162770	MONOMAC1	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.5634514699600761	[218]	[370]	5	hSpCas9	negative selection	12000840
197328567	197328590	1	-	28162770	OCIAML2	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	-0.44624566661520193	[43]	[178]	-4	hSpCas9	negative selection	12170198
197421564	197421587	1	-	28162770	OCIAML2	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	0.6397941644514893	[98]	[854]	6	hSpCas9	negative selection	12170199
197328697	197328720	1	+	28162770	OCIAML2	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	0.05165144272286004	[97]	[562]	0	hSpCas9	negative selection	12170200
197356975	197356998	1	-	28162770	OCIAML2	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	-0.39306884194850855	[85]	[362]	-3	hSpCas9	negative selection	12170201
197421319	197421342	1	+	28162770	OCIAML2	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	-0.004311821019624018	[75]	[419]	0	hSpCas9	negative selection	12170202
197421361	197421384	1	-	28162770	OCIAML2	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	-0.4366824933188237	[20]	[85]	-3	hSpCas9	negative selection	12170203
197421500	197421523	1	+	28162770	OCIAML2	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	0.5293701747578385	[24]	[199]	5	hSpCas9	negative selection	12170204
197421535	197421558	1	+	28162770	OCIAML2	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	-0.1098824814642706	[21]	[112]	-1	hSpCas9	negative selection	12170205
197328891	197328914	1	+	28162770	OCIAML2	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.15386103966563247	[59]	[369]	1	hSpCas9	negative selection	12170206
197328567	197328590	1	-	28162770	OCIAML3	viability	GACAGGGATTGGAGAAGCAAGGG	CRB1	ENSG00000134376	0.2786130531996094	[70]	[259]	2	hSpCas9	negative selection	12339564
197421564	197421587	1	-	28162770	OCIAML3	viability	GGAGTCGTCGATTAAGGTAAGGG	CRB1	ENSG00000134376	1.1466057308571875	[157]	[1055]	8	hSpCas9	negative selection	12339565
197328697	197328720	1	+	28162770	OCIAML3	viability	AAGAACTCCTGCCAACATGGAGG	CRB1	ENSG00000134376	-0.695384660699245	[139]	[260]	-5	hSpCas9	negative selection	12339566
197356975	197356998	1	-	28162770	OCIAML3	viability	ACAGATACAGACATAACCTGAGG	CRB1	ENSG00000134376	0.7589473501838236	[91]	[469]	6	hSpCas9	negative selection	12339567
197421319	197421342	1	+	28162770	OCIAML3	viability	AAGTGGCTCAGTGACAACCAAGG	CRB1	ENSG00000134376	0.4927536715951204	[120]	[513]	4	hSpCas9	negative selection	12339568
197421361	197421384	1	-	28162770	OCIAML3	viability	GCTGAACAGTCTGAAACCTGAGG	CRB1	ENSG00000134376	-0.21153800350175012	[27]	[72]	-2	hSpCas9	negative selection	12339569
197421500	197421523	1	+	28162770	OCIAML3	viability	ATTTCCCACAACACCAGCGATGG	CRB1	ENSG00000134376	0.4478125353704639	[50]	[209]	4	hSpCas9	negative selection	12339570
197421535	197421558	1	+	28162770	OCIAML3	viability	CGTGGAGGTAATATTTGCAGAGG	CRB1	ENSG00000134376	0.3950212418548337	[32]	[130]	3	hSpCas9	negative selection	12339571
197328891	197328914	1	+	28162770	OCIAML3	viability	CAGACACTGCGACTTGGAAGTGG	CRB1	ENSG00000134376	0.9531115092523205	[102]	[601]	8	hSpCas9	negative selection	12339572