Crispr

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 11034
  • Symbol: DSTN
  • Description: destrin, actin depolymerizing factor
DataSource: http://genomecrispr.dkfz.de/#!/results/DSTN

Export (tab separated) Export to Excel
Start The end chr strand pubmed cellline condition sequence symbol ensg log2fc rc_initial rc_final effect cas screentype index
17607137 17607160 20 - 26472758 Jiyoye viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.11766876431088838 [120] [98] 0 hSpCas9 negative selection 46822
17604585 17604608 20 + 26472758 Jiyoye viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 3.2331459817308246 [10] [77] 9 hSpCas9 negative selection 46823
17607061 17607084 20 + 26472758 Jiyoye viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.3279486903552984 [261] [247] 2 hSpCas9 negative selection 46824
17600881 17600904 20 + 26472758 Jiyoye viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 1.1267874089218117 [183] [302] 7 hSpCas9 negative selection 46825
17600739 17600762 20 - 26472758 Jiyoye viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 0.13604729362574308 [285] [236] 1 hSpCas9 negative selection 46826
17600894 17600917 20 + 26472758 Jiyoye viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.9684878794388259 [505] [194] -6 hSpCas9 negative selection 46827
17607124 17607147 20 - 26472758 Jiyoye viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 1.7291034763932358 [55] [139] 8 hSpCas9 negative selection 46828
17607066 17607089 20 - 26472758 Jiyoye viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.7393718118470628 [223] [281] 5 hSpCas9 negative selection 46829
17607137 17607160 20 - 26472758 KBM7 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 -0.11915510701690213 [337,303] [140,136] -1 hSpCas9 negative selection 237940
17604585 17604608 20 + 26472758 KBM7 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.06826498826937244 [234,160] [110,82] 0 hSpCas9 negative selection 237941
17607061 17607084 20 + 26472758 KBM7 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.40323318644879835 [631,602] [480,298] 4 hSpCas9 negative selection 237942
17600881 17600904 20 + 26472758 KBM7 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.1469918938204714 [1216,857] [530,348] -1 hSpCas9 negative selection 237943
17600739 17600762 20 - 26472758 KBM7 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 0.33959514692317394 [1817,1461] [1428,558] 3 hSpCas9 negative selection 237944
17600894 17600917 20 + 26472758 KBM7 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.42637824959111836 [877,960] [366,286] -4 hSpCas9 negative selection 237945
17607124 17607147 20 - 26472758 KBM7 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 0.14545384568147834 [449,447] [213,252] 1 hSpCas9 negative selection 237946
17607066 17607089 20 - 26472758 KBM7 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.7620809182226116 [1649,1143] [1310,908] 8 hSpCas9 negative selection 237947
17607137 17607160 20 - 26472758 Raji viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.6977392948649741 [177] [66] 6 hSpCas9 negative selection 429058
17604585 17604608 20 + 26472758 Raji viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.9553804419285494 [59] [26] 8 hSpCas9 negative selection 429059
17607061 17607084 20 + 26472758 Raji viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 1.0545316531078646 [277] [133] 8 hSpCas9 negative selection 429060
17600881 17600904 20 + 26472758 Raji viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.13102120395147954 [452] [95] -1 hSpCas9 negative selection 429061
17600739 17600762 20 - 26472758 Raji viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -0.1299451562677194 [711] [150] -1 hSpCas9 negative selection 429062
17600894 17600917 20 + 26472758 Raji viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -1.0602164131224687 [619] [68] -6 hSpCas9 negative selection 429063
17607124 17607147 20 - 26472758 Raji viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 0.5623874419700879 [177] [60] 5 hSpCas9 negative selection 429064
17607066 17607089 20 - 26472758 Raji viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.4675590996179251 [669] [214] 4 hSpCas9 negative selection 429065
17607137 17607160 20 - 26472758 K562 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.7158921725750056 [281] [390] 6 hSpCas9 negative selection 620176
17604585 17604608 20 + 26472758 K562 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.2850607121637929 [139] [143] 2 hSpCas9 negative selection 620177
17607061 17607084 20 + 26472758 K562 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.22411916605591603 [500] [493] 1 hSpCas9 negative selection 620178
17600881 17600904 20 + 26472758 K562 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.8937355381066499 [886] [402] -5 hSpCas9 negative selection 620179
17600739 17600762 20 - 26472758 K562 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -0.29792309588747523 [1183] [812] -2 hSpCas9 negative selection 620180
17600894 17600917 20 + 26472758 K562 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.0626785622951207 [870] [703] 0 hSpCas9 negative selection 620181
17607124 17607147 20 - 26472758 K562 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 0.6943701239864452 [346] [473] 6 hSpCas9 negative selection 620182
17607066 17607089 20 - 26472758 K562 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 1.046104899637359 [1019] [1777] 8 hSpCas9 negative selection 620183
17606062 17606085 20 + 25494202 A375 resistance to PLX-4720 (puromycin) CGCACCATTGCACTCCAGCCAGG DSTN ENSG00000125868 0.4129969310179949 [70,134] [28,30] 1 dCas9-VP64 positive selection 2420943
17569858 17569881 20 - 25494202 A375 resistance to PLX-4720 (puromycin) GTCTGCAGGAGGCTAGAAGGCGG DSTN ENSG00000125868 0.8013256545894087 [20,13] [1,11] 3 dCas9-VP64 positive selection 2440741
17606062 17606085 20 + 25494202 A375 resistance to PLX-4720 (zeocin) CGCACCATTGCACTCCAGCCAGG DSTN ENSG00000125868 0.4348131797167361 [124,104] [58,42] 3 dCas9-VP64 positive selection 2516198
17569858 17569881 20 - 25494202 A375 resistance to PLX-4720 (zeocin) GTCTGCAGGAGGCTAGAAGGCGG DSTN ENSG00000125868 -1.7339049284412387 [124,161] [17,8] -9 dCas9-VP64 positive selection 2535996
17600868 17600891 20 + 27453484 HT29 resistance to T3SS1-dependent cytotoxicity AAGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 0.03045254781255058 [4,4] [3,4] 0 hSpCas9 positive selection 2984531
17600816 17600839 20 + 27453484 HT29 resistance to T3SS1-dependent cytotoxicity AGAAATCAAGAAAAGAAAGAAGG DSTN ENSG00000125868 -0.35072344850627923 [2,2] [2,0] -5 hSpCas9 positive selection 2984532
17600886 17600909 20 + 27453484 HT29 resistance to T3SS1-dependent cytotoxicity GAAGGCAAAGAGATCTTGGTTGG DSTN ENSG00000125868 0.2639747773508219 [3,3] [2,3] 5 hSpCas9 positive selection 2984533
17600805 17600828 20 - 27453484 HT29 resistance to T3SS1-dependent cytotoxicity TTTCTTGATTTCTTCTGGTGTGG DSTN ENSG00000125868 -0.1688471662626027 [3,3] [2,2] -2 hSpCas9 positive selection 2984534
17600868 17600891 20 + 27453484 HT29 resistance to T3SS2-dependent cytotoxicity AAGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 0.2916323697549201 [4,4] [4,3] 5 hSpCas9 positive selection 3052389
17600816 17600839 20 + 27453484 HT29 resistance to T3SS2-dependent cytotoxicity AGAAATCAAGAAAAGAAAGAAGG DSTN ENSG00000125868 0.08092655467389587 [2,2] [1,1] 1 hSpCas9 positive selection 3052390
17600886 17600909 20 + 27453484 HT29 resistance to T3SS2-dependent cytotoxicity GAAGGCAAAGAGATCTTGGTTGG DSTN ENSG00000125868 0.05630340110018735 [3,3] [2,2] 1 hSpCas9 positive selection 3052391
17600805 17600828 20 - 27453484 HT29 resistance to T3SS2-dependent cytotoxicity TTTCTTGATTTCTTCTGGTGTGG DSTN ENSG00000125868 -0.0025640093315177186 [3,3] [2,1] 0 hSpCas9 positive selection 3052392
17607042 17607065 + 24336571 A375 resistance to PLX after 7 days AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 -0.5060060412791554 [5,5] [3,3] -9 hSpCas9 positive selection 3110746
17604585 17604608 + 24336571 A375 resistance to PLX after 7 days AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.1597718680496815 [12,11] [14,13] 5 hSpCas9 positive selection 3110747
17604610 17604633 + 24336571 A375 resistance to PLX after 7 days GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 -0.0977586976645064 [2,1] [1,1] -3 hSpCas9 positive selection 3110748
17607042 17607065 + 24336571 A375 resistance to PLX after 14 days AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 -0.2645612554083696 [4,6] [1,1] -3 hSpCas9 positive selection 3168539
17604585 17604608 + 24336571 A375 resistance to PLX after 14 days AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.36345866618113537 [12,13] [9,5] 3 hSpCas9 positive selection 3168540
17604610 17604633 + 24336571 A375 resistance to PLX after 14 days GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.8764745761594521 [1,1] [1,1] 7 hSpCas9 positive selection 3168541
17607042 17607065 + 24336571 A375 viability after 7 days AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 -0.04829429445454125 [5] [5,5] 0 hSpCas9 negative selection 3226332
17604585 17604608 + 24336571 A375 viability after 7 days AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.5420410012596023 [19] [12,11] -6 hSpCas9 negative selection 3226333
17604610 17604633 + 24336571 A375 viability after 7 days GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 -0.25091955510643316 [2] [2,1] -4 hSpCas9 negative selection 3226334
17607042 17607065 + 24336571 A375 viability after 14 days AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 -0.01911067424276558 [5] [4,6] 0 hSpCas9 negative selection 3284125
17604585 17604608 + 24336571 A375 viability after 14 days AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.4864072610438574 [19] [12,13] -5 hSpCas9 negative selection 3284126
17604610 17604633 + 24336571 A375 viability after 14 days GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 -0.5485479661892405 [2] [1,1] -6 hSpCas9 negative selection 3284127
17607084 17607107 20 + 27383988 293T resistance to West Nile virus (flavivirus) GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.2611619915010233 [151,102] [0,0] 1 hSpCas9 positive selection 3347020
17604585 17604608 20 + 27383988 293T resistance to West Nile virus (flavivirus) AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 2.8654578766211722 [19,21] [0,0] 8 hSpCas9 positive selection 3347021
17607042 17607065 20 + 27383988 293T resistance to West Nile virus (flavivirus) AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 1.3991826499717177 [58,56] [0,0] 6 hSpCas9 positive selection 3347022
17604610 17604633 20 + 27383988 293T resistance to West Nile virus (flavivirus) GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.06750165256581787 [145,145] [0,0] 0 hSpCas9 positive selection 3366221
17600815 17600838 20 + 27383988 293T resistance to West Nile virus (flavivirus) AGAAATCAAGAAAAGAAAGAAGG DSTN ENSG00000125868 4.087401210003523 [8,8] [0,0] 9 hSpCas9 positive selection 3366222
17600867 17600890 20 + 27383988 293T resistance to West Nile virus (flavivirus) AAGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 0.5430806937797126 [104,104] [0,0] 2 hSpCas9 positive selection 3366223
17600867 17600890 20 + 26780180 HT29 viability (Avana library 4 designs) AAGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 0.93215630646573 [] [] 3 hSpCas9 negative selection 3421318
17600815 17600838 20 + 26780180 HT29 viability (Avana library 4 designs) AGAAATCAAGAAAAGAAAGAAGG DSTN ENSG00000125868 1.056415073296 [] [] 4 hSpCas9 negative selection 3421319
17600885 17600908 20 + 26780180 HT29 viability (Avana library 4 designs) GAAGGCAAAGAGATCTTGGTTGG DSTN ENSG00000125868 3.15974038868916 [] [] 8 hSpCas9 negative selection 3421320
17600805 17600828 20 - 26780180 HT29 viability (Avana library 4 designs) TTTCTTGATTTCTTCTGGTGTGG DSTN ENSG00000125868 0.784055036578722 [] [] 3 hSpCas9 negative selection 3421321
17600815 17600838 20 + 26780180 A375 viability (Avana lentiCRISPRv2) AGAAATCAAGAAAAGAAAGAAGG DSTN ENSG00000125868 -23.2075340824486 [] [] -9 hSpCas9 negative selection 3501421
17600867 17600890 20 + 26780180 A375 viability (Avana lentiCRISPRv2) AAGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -6.61705319815143 [] [] -6 hSpCas9 negative selection 3501422
17600805 17600828 20 - 26780180 A375 viability (Avana lentiCRISPRv2) TTTCTTGATTTCTTCTGGTGTGG DSTN ENSG00000125868 -2.2821309384419 [] [] -3 hSpCas9 negative selection 3501423
17600885 17600908 20 + 26780180 A375 viability (Avana lentiCRISPRv2) GAAGGCAAAGAGATCTTGGTTGG DSTN ENSG00000125868 -9.78906987420162 [] [] -7 hSpCas9 negative selection 3501424
17600933 17600956 20 - 26780180 A375 viability (Avana lentiCRISPRv2) ATTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 2.28411274611686 [] [] 3 hSpCas9 negative selection 3501425
17600922 17600945 20 - 26780180 A375 viability (Avana lentiCRISPRv2) ATGCTTGAAAGGATCAGTTATGG DSTN ENSG00000125868 -5.00499028037077 [] [] -5 hSpCas9 negative selection 3501426
17600815 17600838 20 + 26780180 A375 viability (Avana lentiGuide) AGAAATCAAGAAAAGAAAGAAGG DSTN ENSG00000125868 11.1648629921259 [] [] 7 hSpCas9 negative selection 3610080
17600867 17600890 20 + 26780180 A375 viability (Avana lentiGuide) AAGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 4.75508156613091 [] [] 4 hSpCas9 negative selection 3610081
17600805 17600828 20 - 26780180 A375 viability (Avana lentiGuide) TTTCTTGATTTCTTCTGGTGTGG DSTN ENSG00000125868 -1.76625686969282 [] [] -3 hSpCas9 negative selection 3610082
17600885 17600908 20 + 26780180 A375 viability (Avana lentiGuide) GAAGGCAAAGAGATCTTGGTTGG DSTN ENSG00000125868 20.4530359681144 [] [] 8 hSpCas9 negative selection 3610083
17600933 17600956 20 - 26780180 A375 viability (Avana lentiGuide) ATTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 -6.97416433527449 [] [] -9 hSpCas9 negative selection 3610084
17600922 17600945 20 - 26780180 A375 viability (Avana lentiGuide) ATGCTTGAAAGGATCAGTTATGG DSTN ENSG00000125868 -4.62954373828951 [] [] -7 hSpCas9 negative selection 3610085
17600815 17600838 20 + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) AGAAATCAAGAAAAGAAAGAAGG DSTN ENSG00000125868 -1.5200886630706765 [8] [2,1] -9 hSpCas9 positive selection 3718739
17600867 17600890 20 + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) AAGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -0.4604291979045094 [7] [5,4] -6 hSpCas9 positive selection 3718740
17600805 17600828 20 - 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) TTTCTTGATTTCTTCTGGTGTGG DSTN ENSG00000125868 -0.08676178224702573 [5] [5,4] -1 hSpCas9 positive selection 3718741
17600885 17600908 20 + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) GAAGGCAAAGAGATCTTGGTTGG DSTN ENSG00000125868 -0.059747377388983294 [5] [5,5] -1 hSpCas9 positive selection 3718742
17600933 17600956 20 - 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) ATTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 0.09519152942507113 [5] [6,5] 2 hSpCas9 positive selection 3718743
17600922 17600945 20 - 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) ATGCTTGAAAGGATCAGTTATGG DSTN ENSG00000125868 -0.30021470570669734 [8] [6,6] -4 hSpCas9 positive selection 3718744
17600815 17600838 20 + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) AGAAATCAAGAAAAGAAAGAAGG DSTN ENSG00000125868 -0.3095363787633415 [4] [3,2] -4 hSpCas9 positive selection 3827346
17600867 17600890 20 + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) AAGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -0.1988740283504886 [6] [4,4] -3 hSpCas9 positive selection 3827347
17600805 17600828 20 - 26780180 A375 resistance to vemurafenib (Avana lentiGuide) TTTCTTGATTTCTTCTGGTGTGG DSTN ENSG00000125868 -0.6610141176885743 [4] [0,3] -7 hSpCas9 positive selection 3827348
17600885 17600908 20 + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) GAAGGCAAAGAGATCTTGGTTGG DSTN ENSG00000125868 -0.6195320077267499 [5] [1,3] -7 hSpCas9 positive selection 3827349
17600933 17600956 20 - 26780180 A375 resistance to vemurafenib (Avana lentiGuide) ATTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 0.04693458764819919 [4] [3,4] 1 hSpCas9 positive selection 3827350
17600922 17600945 20 - 26780180 A375 resistance to vemurafenib (Avana lentiGuide) ATGCTTGAAAGGATCAGTTATGG DSTN ENSG00000125868 0.27324112249556826 [6] [7,6] 7 hSpCas9 positive selection 3827351
17607042 17607065 20 + 26780180 A375 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.210225791291396 [] [] 0 hSpCas9 negative selection 3934782
17604585 17604608 20 + 26780180 A375 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.950194588787975 [] [] 4 hSpCas9 negative selection 3934783
17604610 17604633 20 + 26780180 A375 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.452360854867764 [] [] 1 hSpCas9 negative selection 3934784
17607084 17607107 20 + 26780180 A375 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 1.29960125901194 [] [] 7 hSpCas9 negative selection 3934785
17607042 17607065 20 + 26780180 HT29 viability (GeCKOv2 library) AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.332578486712005 [] [] 0 hSpCas9 negative selection 4042748
17604585 17604608 20 + 26780180 HT29 viability (GeCKOv2 library) AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 1.08093451184353 [] [] 5 hSpCas9 negative selection 4042749
17604610 17604633 20 + 26780180 HT29 viability (GeCKOv2 library) GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.350877136097669 [] [] 1 hSpCas9 negative selection 4042750
17607084 17607107 20 + 26780180 HT29 viability (GeCKOv2 library) GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.557124424102112 [] [] 1 hSpCas9 negative selection 4042751
17607042 17607065 20 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.14545451695949807 [1] [1,0] 4 hSpCas9 positive selection 4133304
17604585 17604608 20 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.16994664845088764 [3] [2,2] 4 hSpCas9 positive selection 4133305
17604610 17604633 20 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 -0.6085329769274679 [1] [0,0] -9 hSpCas9 positive selection 4133306
17607042 17607065 20 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiGuide) AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.15493912828375203 [2] [0,1,2,0] 1 hSpCas9 positive selection 4197326
17604585 17604608 20 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiGuide) AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.39506231664987146 [4] [5,4,4,0] 3 hSpCas9 positive selection 4197327
17604610 17604633 20 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiGuide) GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.8537014695200975 [3] [2,3,1,3] 5 hSpCas9 positive selection 4197328
17607084 17607107 20 + 26780180 A375 resistance to vemurafenib (GeCKOv2 lentiGuide) GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.14130415055983714 [2] [2,2] 3 hSpCas9 positive selection 4267735
17604585 17604608 20 + 26780180 A375 resistance to vemurafenib (GeCKOv2 lentiGuide) AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.14449278221612732 [1] [1,1] 3 hSpCas9 positive selection 4267736
17607042 17607065 20 + 26780180 A375 resistance to vemurafenib (GeCKOv2 lentiGuide) AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.2660476647153318 [2] [3,1] 5 hSpCas9 positive selection 4267737
17604610 17604633 20 + 26780180 A375 resistance to vemurafenib (GeCKOv2 lentiGuide) GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.5725574153526686 [2] [2,2] 9 hSpCas9 positive selection 4332001
17600868 17600890 20 + 27760321 OCIAML3 viability AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -0.826529483331615 [71,91] [30,43] -7 hSpCas9 negative selection 4396009
17600882 17600904 20 + 27760321 OCIAML3 viability GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 0.018524627331514942 [97,95] [40,123] 0 hSpCas9 negative selection 4396010
17600895 17600917 20 + 27760321 OCIAML3 viability AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.7851113567463713 [454,367] [193,174] -6 hSpCas9 negative selection 4396011
17600933 17600955 20 - 27760321 OCIAML3 viability TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 -0.05475600682658288 [140,121] [106,87] 0 hSpCas9 negative selection 4396012
17600868 17600890 20 + 27760321 OCIAML2 viability AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 0.46105099894709634 [71,91] [98,83] 6 hSpCas9 negative selection 4479472
17600882 17600904 20 + 27760321 OCIAML2 viability GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 0.2687516592774537 [97,95] [86,104] 3 hSpCas9 negative selection 4479473
17600895 17600917 20 + 27760321 OCIAML2 viability AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.29578466202825526 [454,367] [289,242] -4 hSpCas9 negative selection 4479474
17600933 17600955 20 - 27760321 OCIAML2 viability TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 0.04031506260066808 [140,121] [93,128] 0 hSpCas9 negative selection 4479475
17600868 17600890 20 + 27760321 MV411 viability AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -1.2032736569591922 [71,91] [38,0] -7 hSpCas9 negative selection 4562935
17600882 17600904 20 + 27760321 MV411 viability GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -2.9691737853508138 [97,95] [0,18] -9 hSpCas9 negative selection 4562936
17600895 17600917 20 + 27760321 MV411 viability AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.13064524553794415 [454,367] [127,424] -1 hSpCas9 negative selection 4562937
17600933 17600955 20 - 27760321 MV411 viability TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 0.15739881511516374 [140,121] [4,233] 1 hSpCas9 negative selection 4562938
17600868 17600890 20 + 27760321 HL60 viability AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -0.7981573660593644 [71,91] [6,72] -7 hSpCas9 negative selection 4646398
17600882 17600904 20 + 27760321 HL60 viability GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 0.9320946828607546 [97,95] [169,131] 8 hSpCas9 negative selection 4646399
17600895 17600917 20 + 27760321 HL60 viability AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -1.0780372858781109 [454,367] [186,127] -8 hSpCas9 negative selection 4646400
17600933 17600955 20 - 27760321 HL60 viability TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 -0.0010876462232651818 [140,121] [141,69] 0 hSpCas9 negative selection 4646401
17600868 17600890 20 + 27760321 HT1080 viability AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -5.029980070239602 [91,71] [0,0] -8 hSpCas9 negative selection 4729861
17600882 17600904 20 + 27760321 HT1080 viability GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -5.090125400356522 [95,74] [0,0] -8 hSpCas9 negative selection 4729862
17600895 17600917 20 + 27760321 HT1080 viability AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 0.3789031437422652 [367,286] [119,223] 2 hSpCas9 negative selection 4729863
17600933 17600955 20 - 27760321 HT1080 viability TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 0.8584299368791615 [121,94] [127,23] 4 hSpCas9 negative selection 4729864
17600868 17600890 20 + 27760321 HT29 viability after 7 days AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -0.05081303187986297 [91,71] [49,86,158] 0 hSpCas9 negative selection 4813324
17600882 17600904 20 + 27760321 HT29 viability after 7 days GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 0.4605340215988445 [95,74] [40,280,116] 7 hSpCas9 negative selection 4813325
17600895 17600917 20 + 27760321 HT29 viability after 7 days AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.4429749506994971 [367,286] [393,180,363] -6 hSpCas9 negative selection 4813326
17600933 17600955 20 - 27760321 HT29 viability after 7 days TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 0.5786152155917228 [121,94] [250,212,167] 8 hSpCas9 negative selection 4813327
17600868 17600890 20 + 27760321 HT29 viability after 25 days AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 0.45332851642288907 [91,71] [117,142,123] 5 hSpCas9 negative selection 4896787
17600882 17600904 20 + 27760321 HT29 viability after 25 days GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 0.13209924844370868 [95,74] [10,218,95] 1 hSpCas9 negative selection 4896788
17600895 17600917 20 + 27760321 HT29 viability after 25 days AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.20727325892099582 [367,286] [440,187,336] -2 hSpCas9 negative selection 4896789
17600933 17600955 20 - 27760321 HT29 viability after 25 days TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 -0.1322490816947497 [121,94] [193,44,92] -1 hSpCas9 negative selection 4896790
17600868 17600890 20 + 27760321 HT29 viability after 22 days AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -0.1540855912051029 [91,71] [166,43,41] -1 hSpCas9 negative selection 4980250
17600882 17600904 20 + 27760321 HT29 viability after 22 days GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 0.26266463031027687 [95,74] [29,120,207] 2 hSpCas9 negative selection 4980251
17600895 17600917 20 + 27760321 HT29 viability after 22 days AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.566919215088482 [367,286] [240,279,245] -5 hSpCas9 negative selection 4980252
17600933 17600955 20 - 27760321 HT29 viability after 22 days TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 -0.032270507867046216 [121,94] [107,169,89] 0 hSpCas9 negative selection 4980253
17600868 17600890 20 + 27760321 HT29 viability after 19 days AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -0.4024025674881284 [91,71] [155,54,12] -4 hSpCas9 negative selection 5063713
17600882 17600904 20 + 27760321 HT29 viability after 19 days GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 1.3169827342684286 [95,74] [56,377,274] 9 hSpCas9 negative selection 5063714
17600895 17600917 20 + 27760321 HT29 viability after 19 days AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.1091212008538941 [367,286] [427,328,294] -1 hSpCas9 negative selection 5063715
17600933 17600955 20 - 27760321 HT29 viability after 19 days TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 0.27478784476338936 [121,94] [145,105,195] 2 hSpCas9 negative selection 5063716
17600868 17600890 20 + 27760321 HT29 viability after 16 days AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -0.6255293119666532 [91,71] [67,67,42] -5 hSpCas9 negative selection 5147176
17600882 17600904 20 + 27760321 HT29 viability after 16 days GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.03581405190973719 [95,74] [45,72,156] 0 hSpCas9 negative selection 5147177
17600895 17600917 20 + 27760321 HT29 viability after 16 days AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.2695837282564263 [367,286] [374,207,337] -3 hSpCas9 negative selection 5147178
17600933 17600955 20 - 27760321 HT29 viability after 16 days TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 -0.12448237254301286 [121,94] [129,63,142] -1 hSpCas9 negative selection 5147179
17600868 17600890 20 + 27760321 HT29 viability after 13 days AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -0.435816975743891 [91,71] [29,57,119] -5 hSpCas9 negative selection 5230639
17600882 17600904 20 + 27760321 HT29 viability after 13 days GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 0.07430016109121218 [95,74] [33,81,191] 0 hSpCas9 negative selection 5230640
17600895 17600917 20 + 27760321 HT29 viability after 13 days AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.475092915031442 [367,286] [346,237,236] -5 hSpCas9 negative selection 5230641
17600933 17600955 20 - 27760321 HT29 viability after 13 days TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 0.07214215639160271 [121,94] [126,70,194] 0 hSpCas9 negative selection 5230642
17600868 17600890 20 + 27760321 HT29 viability after 10 days AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -0.7536404979643154 [91,71] [62,95,24] -7 hSpCas9 negative selection 5314102
17600882 17600904 20 + 27760321 HT29 viability after 10 days GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 0.17171799046331593 [95,74] [87,159,113] 2 hSpCas9 negative selection 5314103
17600895 17600917 20 + 27760321 HT29 viability after 10 days AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.3252816767029769 [367,286] [378,282,315] -4 hSpCas9 negative selection 5314104
17600933 17600955 20 - 27760321 HT29 viability after 10 days TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 0.48347219484720294 [121,94] [120,97,342] 6 hSpCas9 negative selection 5314105
17600868 17600890 20 + 27760321 MOLM13 viability AGTGCATCATTGTAGAAGAAGG DSTN ENSG00000125868 -1.3162692681252746 [71,91] [0,33] -6 hSpCas9 negative selection 5397565
17600882 17600904 20 + 27760321 MOLM13 viability GAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -2.5914416072527406 [97,95] [0,15] -8 hSpCas9 negative selection 5397566
17600895 17600917 20 + 27760321 MOLM13 viability AGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.7929910820228473 [454,367] [95,164] -5 hSpCas9 negative selection 5397567
17600933 17600955 20 - 27760321 MOLM13 viability TTCCCACAAAATGCTTGAAAGG DSTN ENSG00000125868 0.5964153765264169 [140,121] [52,161] 4 hSpCas9 negative selection 5397568
17570076 17570099 20 - 27661255 K562 viability GGCGGCGCGAGCTTACCCCGGGG DSTN ENSG00000125868 0.022479857753869403 [315,440] [348,267] 0 dCas9-KRAB negative selection 5476062
17570128 17570151 20 - 27661255 K562 viability GACCGTCCTCCTCACGGCTGCGG DSTN ENSG00000125868 0.09508878054417466 [696,770] [609,637] 3 dCas9-KRAB negative selection 5476063
17570373 17570396 20 - 27661255 K562 viability GCCAGGACGGCGGGAGACGGAGG DSTN ENSG00000125868 -0.2672537161738163 [934,635] [525,523] -6 dCas9-KRAB negative selection 5476064
17570474 17570497 20 - 27661255 K562 viability GGGTCTGGAGACACCCGCAGAGG DSTN ENSG00000125868 0.07564068219386039 [1010,1121] [921,873] 2 dCas9-KRAB negative selection 5476065
17570552 17570575 20 - 27661255 K562 viability GGCCTCGGTGTGCAGACCCCCGG DSTN ENSG00000125868 0.017202937517046712 [457,564] [466,364] 0 dCas9-KRAB negative selection 5476066
17607084 17607107 20 + 27260156 BXPC3 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.147605719002607 [445] [491,410,522,663] 3 hSpCas9 negative selection 5540195
17604585 17604608 20 + 27260156 BXPC3 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.42878922670466335 [149] [112,74,130,153] -7 hSpCas9 negative selection 5540196
17607042 17607065 20 + 27260156 BXPC3 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.23456797121242912 [280] [372,370,289,339] 5 hSpCas9 negative selection 5540197
17604610 17604633 20 + 27260156 BXPC3 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.3595727773101415 [267] [294,382,280,497] 7 hSpCas9 negative selection 5604461
17607084 17607107 20 + 27260156 A673 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.3085282517181184 [445] [757,580,627,699] 7 hSpCas9 negative selection 5661446
17604585 17604608 20 + 27260156 A673 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.1891768074980642 [149] [103,118,223,179] -5 hSpCas9 negative selection 5661447
17607042 17607065 20 + 27260156 A673 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.20542551317647273 [280] [419,360,413,362] 5 hSpCas9 negative selection 5661448
17604610 17604633 20 + 27260156 A673 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.496143931144103 [267] [438,368,379,637] 9 hSpCas9 negative selection 5725712
17607084 17607107 20 + 27260156 A375 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.277075865069635 [445] [501,714,692,623] 4 hSpCas9 negative selection 5782697
17604585 17604608 20 + 27260156 A375 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.29005651772943186 [149] [185,115,131,135] -4 hSpCas9 negative selection 5782698
17607042 17607065 20 + 27260156 A375 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.6311058836466126 [280] [550,675,523,325] 8 hSpCas9 negative selection 5782699
17604610 17604633 20 + 27260156 A375 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.7107615461170071 [267] [458,611,516,476] 9 hSpCas9 negative selection 5846963
17607084 17607107 20 + 27260156 COLO741 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.28545516995116893 [445] [536,655,862] 6 hSpCas9 negative selection 5903948
17604585 17604608 20 + 27260156 COLO741 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.032775052665357185 [149] [276,184,136] 0 hSpCas9 negative selection 5903949
17607042 17607065 20 + 27260156 COLO741 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.20511713835900403 [280] [279,428,512] 4 hSpCas9 negative selection 5903950
17604610 17604633 20 + 27260156 COLO741 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.6256993104867967 [267] [698,579,333] 9 hSpCas9 negative selection 5968214
17607084 17607107 20 + 27260156 CAL120 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.19604253092523488 [445] [761,524,638] 3 hSpCas9 negative selection 6025199
17604585 17604608 20 + 27260156 CAL120 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.6930928947843078 [149] [216,107,37] -7 hSpCas9 negative selection 6025200
17607042 17607065 20 + 27260156 CAL120 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 -0.06787383476542441 [280] [287,326,377] -1 hSpCas9 negative selection 6025201
17604610 17604633 20 + 27260156 CAL120 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.9309744097102506 [267] [561,1026,312] 9 hSpCas9 negative selection 6089465
17607084 17607107 20 + 27260156 CADOES1 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 -0.14454434694744475 [445] [383,269,363,486] -2 hSpCas9 negative selection 6146450
17604585 17604608 20 + 27260156 CADOES1 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.40150434210719754 [149] [69,112,122,116] -6 hSpCas9 negative selection 6146451
17607042 17607065 20 + 27260156 CADOES1 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.6417348509359584 [280] [429,550,249,399] 9 hSpCas9 negative selection 6146452
17604610 17604633 20 + 27260156 CADOES1 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.6357707989223045 [267] [484,347,374,338] 9 hSpCas9 negative selection 6210716
17607084 17607107 20 + 27260156 EWS502 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.005525449621887141 [445] [411,458,451,587] 0 hSpCas9 negative selection 6267701
17604585 17604608 20 + 27260156 EWS502 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.28413577066816353 [149] [154,124,96,141] -5 hSpCas9 negative selection 6267702
17607042 17607065 20 + 27260156 EWS502 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.32341239646777814 [280] [332,480,374,293] 5 hSpCas9 negative selection 6267703
17604610 17604633 20 + 27260156 EWS502 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.5050187728911383 [267] [398,354,422,437] 8 hSpCas9 negative selection 6331967
17607084 17607107 20 + 27260156 EW8 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.30029592885766093 [445] [533,412,395,453] 5 hSpCas9 negative selection 6388952
17604585 17604608 20 + 27260156 EW8 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.3249591126822833 [149] [115,90,48,141] -6 hSpCas9 negative selection 6388953
17607042 17607065 20 + 27260156 EW8 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.5850971386691588 [280] [366,303,323,375] 8 hSpCas9 negative selection 6388954
17604610 17604633 20 + 27260156 EW8 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.7026945434079661 [267] [439,318,385,271] 9 hSpCas9 negative selection 6453218
17607084 17607107 20 + 27260156 CORL105 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.26509332207168557 [445] [597,504,862,581] 5 hSpCas9 negative selection 6510203
17604585 17604608 20 + 27260156 CORL105 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.3968122499937803 [149] [110,92,206,133] -6 hSpCas9 negative selection 6510204
17607042 17607065 20 + 27260156 CORL105 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.6699295469747607 [280] [454,369,922,408] 9 hSpCas9 negative selection 6510205
17604610 17604633 20 + 27260156 CORL105 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.45924803907151684 [267] [361,480,488,398] 8 hSpCas9 negative selection 6574469
17607084 17607107 20 + 27260156 HS294T viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 -0.19580246206707647 [445] [82,166,195,163] -3 hSpCas9 negative selection 6631454
17604585 17604608 20 + 27260156 HS294T viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -1.4824016283540715 [149] [15,9,25,33] -9 hSpCas9 negative selection 6631455
17607042 17607065 20 + 27260156 HS294T viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.40630997200962615 [280] [193,146,117,104] 5 hSpCas9 negative selection 6631456
17604610 17604633 20 + 27260156 HS294T viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.4045903243044963 [267] [159,96,124,170] 5 hSpCas9 negative selection 6695720
17607084 17607107 20 + 27260156 HCC44 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.2670098336895486 [445] [674,748,695,313] 4 hSpCas9 negative selection 6752705
17604585 17604608 20 + 27260156 HCC44 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.475459194503119 [149] [66,102,204,123] -6 hSpCas9 negative selection 6752706
17607042 17607065 20 + 27260156 HCC44 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.42454800515615926 [280] [389,375,728,268] 7 hSpCas9 negative selection 6752707
17604610 17604633 20 + 27260156 HCC44 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.7710310863492135 [267] [623,429,391,615] 9 hSpCas9 negative selection 6816971
17607084 17607107 20 + 27260156 G402 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.6702484801622192 [445] [1180,884,525,912] 8 hSpCas9 negative selection 6873956
17604585 17604608 20 + 27260156 G402 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.17646493892658066 [149] [184,193,158,280] 2 hSpCas9 negative selection 6873957
17607042 17607065 20 + 27260156 G402 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.8548737001342233 [280] [468,807,671,522] 9 hSpCas9 negative selection 6873958
17604610 17604633 20 + 27260156 G402 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 1.0031649579378372 [267] [790,445,909,487] 9 hSpCas9 negative selection 6938222
17607084 17607107 20 + 27260156 L33 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.44894185369887685 [445] [675,282,322,552] 8 hSpCas9 negative selection 6995207
17604585 17604608 20 + 27260156 L33 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.22614075111210963 [149] [132,58,75,114] -5 hSpCas9 negative selection 6995208
17607042 17607065 20 + 27260156 L33 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 -0.3269713010955758 [280] [182,71,186,240] -6 hSpCas9 negative selection 6995209
17604610 17604633 20 + 27260156 L33 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.384592195759254 [267] [336,116,255,369] 7 hSpCas9 negative selection 7059473
17607084 17607107 20 + 27260156 K562 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.014500424684936487 [445] [302,507,372,409] 0 hSpCas9 negative selection 7116458
17604585 17604608 20 + 27260156 K562 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.7327360294698944 [149] [41,21,66,171] -7 hSpCas9 negative selection 7116459
17607042 17607065 20 + 27260156 K562 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.058795897387594276 [280] [186,336,346,174] 0 hSpCas9 negative selection 7116460
17604610 17604633 20 + 27260156 K562 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.6242783384254529 [267] [390,886,130,114] 7 hSpCas9 negative selection 7180724
17607084 17607107 20 + 27260156 HT29 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.2669153053522421 [445] [744,658,606,606] 5 hSpCas9 negative selection 7237709
17604585 17604608 20 + 27260156 HT29 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.08206651349738325 [149] [225,242,182,132] 1 hSpCas9 negative selection 7237710
17607042 17607065 20 + 27260156 HT29 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.08699364048979641 [280] [393,385,354,322] 1 hSpCas9 negative selection 7237711
17604610 17604633 20 + 27260156 HT29 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.6412686904036393 [267] [526,466,580,457] 9 hSpCas9 negative selection 7301975
17607084 17607107 20 + 27260156 MHHES1 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.04725813735972112 [445] [380,758,573,388] 0 hSpCas9 negative selection 7358960
17604585 17604608 20 + 27260156 MHHES1 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.46996572424468197 [149] [74,198,161,64] -7 hSpCas9 negative selection 7358961
17607042 17607065 20 + 27260156 MHHES1 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.6650497423129293 [280] [413,692,497,418] 9 hSpCas9 negative selection 7358962
17604610 17604633 20 + 27260156 MHHES1 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.5181654046280935 [267] [505,538,307,393] 8 hSpCas9 negative selection 7423226
17607084 17607107 20 + 27260156 MEWO viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.2530392168706709 [445] [678,469,377] 5 hSpCas9 negative selection 7480211
17604585 17604608 20 + 27260156 MEWO viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.07874873612244349 [149] [169,91,143] -2 hSpCas9 negative selection 7480212
17607042 17607065 20 + 27260156 MEWO viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.17180362083805667 [280] [401,267,238] 4 hSpCas9 negative selection 7480213
17604610 17604633 20 + 27260156 MEWO viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.5691342060024995 [267] [341,388,378] 9 hSpCas9 negative selection 7544477
17607084 17607107 20 + 27260156 LNCAPCLONEFGC viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.24952572339580734 [445] [494,415,649,388] 4 hSpCas9 negative selection 7601462
17604585 17604608 20 + 27260156 LNCAPCLONEFGC viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.4691763262979365 [149] [70,136,60,115] -6 hSpCas9 negative selection 7601463
17607042 17607065 20 + 27260156 LNCAPCLONEFGC viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.33389455563134257 [280] [248,354,271,398] 5 hSpCas9 negative selection 7601464
17604610 17604633 20 + 27260156 LNCAPCLONEFGC viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.6060543937786856 [267] [513,379,326,246] 8 hSpCas9 negative selection 7665728
17607084 17607107 20 + 27260156 PANC0327 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.2814884516856623 [445] [814,397,356,393] 4 hSpCas9 negative selection 7722713
17604585 17604608 20 + 27260156 PANC0327 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.1477816691807885 [149] [107,196,37,126] -2 hSpCas9 negative selection 7722714
17607042 17607065 20 + 27260156 PANC0327 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.44977652953198527 [280] [222,266,608,264] 6 hSpCas9 negative selection 7722715
17604610 17604633 20 + 27260156 PANC0327 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.2897192014085882 [267] [225,172,400,373] 4 hSpCas9 negative selection 7786979
17607084 17607107 20 + 27260156 NCIH2009 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.4222278983073842 [445] [1064,560,927] 6 hSpCas9 negative selection 7843964
17604585 17604608 20 + 27260156 NCIH2009 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.5571345380970685 [149] [315,107,37] -6 hSpCas9 negative selection 7843965
17607042 17607065 20 + 27260156 NCIH2009 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 -0.3486896352997254 [280] [348,442,137] -5 hSpCas9 negative selection 7843966
17604610 17604633 20 + 27260156 NCIH2009 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.7102011075521825 [267] [600,526,707] 8 hSpCas9 negative selection 7908230
17607084 17607107 20 + 27260156 NCIH1373 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.2801975903384953 [445] [493,805,454,166] 2 hSpCas9 negative selection 7965215
17604585 17604608 20 + 27260156 NCIH1373 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.9304871535571368 [149] [91,81,119,14] -7 hSpCas9 negative selection 7965216
17607042 17607065 20 + 27260156 NCIH1373 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 1.089197633163385 [280] [758,1220,323,81] 9 hSpCas9 negative selection 7965217
17604610 17604633 20 + 27260156 NCIH1373 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 1.3722523827974051 [267] [844,1005,407,221] 9 hSpCas9 negative selection 8029481
17607084 17607107 20 + 27260156 PATU8902 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.20976349138505865 [445] [977,692,337,985] 2 hSpCas9 negative selection 8086466
17604585 17604608 20 + 27260156 PATU8902 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -1.2843476474995772 [149] [154,29,127,7] -8 hSpCas9 negative selection 8086467
17607042 17607065 20 + 27260156 PATU8902 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.7013057172282371 [280] [760,650,412,789] 7 hSpCas9 negative selection 8086468
17604610 17604633 20 + 27260156 PATU8902 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.7326776350975372 [267] [645,772,536,530] 7 hSpCas9 negative selection 8150732
17607084 17607107 20 + 27260156 PANC1 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.489722926888758 [445] [639,494,683,345] 7 hSpCas9 negative selection 8207717
17604585 17604608 20 + 27260156 PANC1 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.525362099722664 [149] [89,173,63,51] -7 hSpCas9 negative selection 8207718
17607042 17607065 20 + 27260156 PANC1 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.5141542134623158 [280] [409,306,351,301] 8 hSpCas9 negative selection 8207719
17604610 17604633 20 + 27260156 PANC1 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 1.073123420288081 [267] [640,432,520,343] 9 hSpCas9 negative selection 8271983
17607084 17607107 20 + 27260156 PANC0813 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.5740176075652998 [445] [846,762,660,848] 8 hSpCas9 negative selection 8328968
17604585 17604608 20 + 27260156 PANC0813 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.9626290921382845 [149] [158,53,68,85] -8 hSpCas9 negative selection 8328969
17607042 17607065 20 + 27260156 PANC0813 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.2065623676304671 [280] [466,290,443,331] 3 hSpCas9 negative selection 8328970
17604610 17604633 20 + 27260156 PANC0813 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.2913356183202156 [267] [405,321,385,425] 5 hSpCas9 negative selection 8393234
17607084 17607107 20 + 27260156 RDES viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.050037954043485565 [445] [467,553,488,618] 0 hSpCas9 negative selection 8450219
17604585 17604608 20 + 27260156 RDES viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.8052803100496158 [149] [67,101,127,101] -8 hSpCas9 negative selection 8450220
17607042 17607065 20 + 27260156 RDES viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.5760731198360297 [280] [428,443,422,654] 8 hSpCas9 negative selection 8450221
17604610 17604633 20 + 27260156 RDES viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.7445815600284735 [267] [371,526,529,676] 9 hSpCas9 negative selection 8514485
17607084 17607107 20 + 27260156 PC3 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.16577954161396646 [445] [328,440,938,483] 3 hSpCas9 negative selection 8571470
17604585 17604608 20 + 27260156 PC3 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.2227634412035675 [149] [60,83,218,209] -5 hSpCas9 negative selection 8571471
17607042 17607065 20 + 27260156 PC3 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.1980252293855005 [280] [161,315,412,480] 4 hSpCas9 negative selection 8571472
17604610 17604633 20 + 27260156 PC3 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.542759765669065 [267] [182,395,629,506] 9 hSpCas9 negative selection 8635736
17607084 17607107 20 + 27260156 PATU8988T viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.31408192727826667 [445] [531,426,484,702] 5 hSpCas9 negative selection 8692721
17604585 17604608 20 + 27260156 PATU8988T viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.09454077279487527 [149] [139,182,79,145] -2 hSpCas9 negative selection 8692722
17607042 17607065 20 + 27260156 PATU8988T viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.06114747599979942 [280] [202,344,331,255] 1 hSpCas9 negative selection 8692723
17604610 17604633 20 + 27260156 PATU8988T viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.8791834917270077 [267] [309,436,252,941] 9 hSpCas9 negative selection 8756987
17607084 17607107 20 + 27260156 T47D viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.4217347173463631 [445] [653,569,745,827] 8 hSpCas9 negative selection 8813972
17604585 17604608 20 + 27260156 T47D viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.2373793148340746 [149] [144,152,135,158] -5 hSpCas9 negative selection 8813973
17607042 17607065 20 + 27260156 T47D viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.46417567511788754 [280] [388,441,577,393] 8 hSpCas9 negative selection 8813974
17604610 17604633 20 + 27260156 T47D viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.5913886378826267 [267] [394,451,488,548] 9 hSpCas9 negative selection 8878238
17607084 17607107 20 + 27260156 SU8686 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.2857865257661637 [445] [463,473,631,613] 5 hSpCas9 negative selection 8935223
17604585 17604608 20 + 27260156 SU8686 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.5544074883387518 [149] [79,57,121,162] -7 hSpCas9 negative selection 8935224
17607042 17607065 20 + 27260156 SU8686 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.041013664467717814 [280] [266,183,294,438] 0 hSpCas9 negative selection 8935225
17604610 17604633 20 + 27260156 SU8686 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.8299384003338716 [267] [334,515,491,568] 9 hSpCas9 negative selection 8999489
17607084 17607107 20 + 27260156 SKES1 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.19583840359170707 [445] [380,731,544,396] 4 hSpCas9 negative selection 9056474
17604585 17604608 20 + 27260156 SKES1 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.3269734058434124 [149] [148,132,99,101] -6 hSpCas9 negative selection 9056475
17607042 17607065 20 + 27260156 SKES1 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.29513498787284675 [280] [370,378,319,313] 6 hSpCas9 negative selection 9056476
17604610 17604633 20 + 27260156 SKES1 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.5708432610611502 [267] [559,350,360,336] 9 hSpCas9 negative selection 9120740
17607084 17607107 20 + 27260156 TOV112D viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.4526727811609265 [445] [654,768,422,638] 8 hSpCas9 negative selection 9177725
17604585 17604608 20 + 27260156 TOV112D viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.04340748244191994 [149] [155,189,170,111] 0 hSpCas9 negative selection 9177726
17607042 17607065 20 + 27260156 TOV112D viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.2241923431053222 [280] [243,492,399,213] 4 hSpCas9 negative selection 9177727
17604610 17604633 20 + 27260156 TOV112D viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.6566057000800201 [267] [398,684,420,253] 9 hSpCas9 negative selection 9241991
17607084 17607107 20 + 27260156 TC71 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.1772994287859267 [445] [446,536,579,602] 4 hSpCas9 negative selection 9298976
17604585 17604608 20 + 27260156 TC71 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.11714904350960009 [149] [201,188,115,192] 3 hSpCas9 negative selection 9298977
17607042 17607065 20 + 27260156 TC71 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.28338992751361 [280] [299,446,336,385] 7 hSpCas9 negative selection 9298978
17604610 17604633 20 + 27260156 TC71 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.6023102859789268 [267] [407,429,469,435] 9 hSpCas9 negative selection 9363242
17607084 17607107 20 + 27260156 TC32 viability GCTTGTATTGCTGAAAAGTTAGG DSTN ENSG00000125868 0.2152923448386997 [445] [374,552,537,442] 4 hSpCas9 negative selection 9420227
17604585 17604608 20 + 27260156 TC32 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.501089717886311 [149] [86,106,120,77] -7 hSpCas9 negative selection 9420228
17607042 17607065 20 + 27260156 TC32 viability AAACATGAATGTCAAGCAAATGG DSTN ENSG00000125868 0.41568715228924596 [280] [197,392,405,405] 7 hSpCas9 negative selection 9420229
17604610 17604633 20 + 27260156 TC32 viability GCAATTAAAAAGAAATTTCAAGG DSTN ENSG00000125868 0.788803966460794 [267] [457,315,612,397] 9 hSpCas9 negative selection 9484493
17607137 17607160 20 - 28162770 P31FUJ viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.3084990675106378 [122] [178] 3 hSpCas9 negative selection 10146747
17604585 17604608 20 + 28162770 P31FUJ viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.2602378068657385 [53] [75] 3 hSpCas9 negative selection 10146748
17607061 17607084 20 + 28162770 P31FUJ viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.7196973719816923 [246] [477] 8 hSpCas9 negative selection 10146749
17600881 17600904 20 + 28162770 P31FUJ viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.7074284999830224 [345] [248] -5 hSpCas9 negative selection 10146750
17600739 17600762 20 - 28162770 P31FUJ viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -0.2502052506758238 [416] [411] -2 hSpCas9 negative selection 10146751
17600894 17600917 20 + 28162770 P31FUJ viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.3314864792737855 [362] [338] -3 hSpCas9 negative selection 10146752
17607124 17607147 20 - 28162770 P31FUJ viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 -0.1321082047949056 [248] [266] -1 hSpCas9 negative selection 10146753
17607066 17607089 20 - 28162770 P31FUJ viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.6456166915831931 [828] [1523] 7 hSpCas9 negative selection 10146754
17607137 17607160 20 - 28162770 TF1 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 NaN [NaN] [194] 1 hSpCas9 negative selection 10316113
17604585 17604608 20 + 28162770 TF1 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 NaN [NaN] [149] 1 hSpCas9 negative selection 10316114
17607061 17607084 20 + 28162770 TF1 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 NaN [NaN] [328] 1 hSpCas9 negative selection 10316115
17600881 17600904 20 + 28162770 TF1 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 NaN [NaN] [196] 1 hSpCas9 negative selection 10316116
17600739 17600762 20 - 28162770 TF1 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 NaN [NaN] [264] 1 hSpCas9 negative selection 10316117
17600894 17600917 20 + 28162770 TF1 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 NaN [NaN] [183] 1 hSpCas9 negative selection 10316118
17607124 17607147 20 - 28162770 TF1 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 NaN [NaN] [157] 1 hSpCas9 negative selection 10316119
17607066 17607089 20 - 28162770 TF1 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 NaN [NaN] [920] 1 hSpCas9 negative selection 10316120
17607137 17607160 20 - 28162770 SKM1 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.203993510510939 [54] [111] 2 hSpCas9 negative selection 10485479
17604585 17604608 20 + 28162770 SKM1 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.5930358012568384 [20] [55] 6 hSpCas9 negative selection 10485480
17607061 17607084 20 + 28162770 SKM1 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.836489838121116 [50] [160] 7 hSpCas9 negative selection 10485481
17600881 17600904 20 + 28162770 SKM1 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.2895066171949848 [111] [161] -2 hSpCas9 negative selection 10485482
17600739 17600762 20 - 28162770 SKM1 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -0.3882450013965726 [133] [180] -3 hSpCas9 negative selection 10485483
17600894 17600917 20 + 28162770 SKM1 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.33455570321511163 [101] [142] -3 hSpCas9 negative selection 10485484
17607124 17607147 20 - 28162770 SKM1 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 -0.5418937788292703 [69] [84] -4 hSpCas9 negative selection 10485485
17607066 17607089 20 - 28162770 SKM1 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.5165837408189653 [154] [391] 5 hSpCas9 negative selection 10485486
17607137 17607160 20 - 28162770 SKM1 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.203993510510939 [54] [111] 2 hSpCas9 negative selection 10654845
17604585 17604608 20 + 28162770 SKM1 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.5930358012568384 [20] [55] 6 hSpCas9 negative selection 10654846
17607061 17607084 20 + 28162770 SKM1 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.836489838121116 [50] [160] 7 hSpCas9 negative selection 10654847
17600881 17600904 20 + 28162770 SKM1 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.2895066171949848 [111] [161] -2 hSpCas9 negative selection 10654848
17600739 17600762 20 - 28162770 SKM1 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -0.3882450013965726 [133] [180] -3 hSpCas9 negative selection 10654849
17600894 17600917 20 + 28162770 SKM1 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.33455570321511163 [101] [142] -3 hSpCas9 negative selection 10654850
17607124 17607147 20 - 28162770 SKM1 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 -0.5418937788292703 [69] [84] -4 hSpCas9 negative selection 10654851
17607066 17607089 20 - 28162770 SKM1 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.5165837408189653 [154] [391] 5 hSpCas9 negative selection 10654852
17607137 17607160 20 - 28162770 PL21 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 -0.22209338619372743 [200] [74] -2 hSpCas9 negative selection 10824211
17604585 17604608 20 + 28162770 PL21 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -1.076700590869504 [62] [12] -6 hSpCas9 negative selection 10824212
17607061 17607084 20 + 28162770 PL21 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.03302962865406178 [255] [113] 0 hSpCas9 negative selection 10824213
17600881 17600904 20 + 28162770 PL21 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.6731032432247414 [391] [106] -5 hSpCas9 negative selection 10824214
17600739 17600762 20 - 28162770 PL21 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 0.08124426540232355 [492] [226] 0 hSpCas9 negative selection 10824215
17600894 17600917 20 + 28162770 PL21 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.667994937636706 [302] [82] -5 hSpCas9 negative selection 10824216
17607124 17607147 20 - 28162770 PL21 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 0.48211558397657417 [226] [137] 4 hSpCas9 negative selection 10824217
17607066 17607089 20 - 28162770 PL21 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.925213312586566 [535] [442] 7 hSpCas9 negative selection 10824218
17607137 17607160 20 - 28162770 P31FUJ viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.3084990675106378 [122] [178] 3 hSpCas9 negative selection 10993577
17604585 17604608 20 + 28162770 P31FUJ viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.2602378068657385 [53] [75] 3 hSpCas9 negative selection 10993578
17607061 17607084 20 + 28162770 P31FUJ viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.7196973719816923 [246] [477] 8 hSpCas9 negative selection 10993579
17600881 17600904 20 + 28162770 P31FUJ viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.7074284999830224 [345] [248] -5 hSpCas9 negative selection 10993580
17600739 17600762 20 - 28162770 P31FUJ viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -0.2502052506758238 [416] [411] -2 hSpCas9 negative selection 10993581
17600894 17600917 20 + 28162770 P31FUJ viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.3314864792737855 [362] [338] -3 hSpCas9 negative selection 10993582
17607124 17607147 20 - 28162770 P31FUJ viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 -0.1321082047949056 [248] [266] -1 hSpCas9 negative selection 10993583
17607066 17607089 20 - 28162770 P31FUJ viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.6456166915831931 [828] [1523] 7 hSpCas9 negative selection 10993584
17607137 17607160 20 - 28162770 OCIAML5 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.044097618151463014 [107] [200] 0 hSpCas9 negative selection 11162943
17604585 17604608 20 + 28162770 OCIAML5 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.04409761815146285 [71] [133] 0 hSpCas9 negative selection 11162944
17607061 17607084 20 + 28162770 OCIAML5 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.3483980115376982 [160] [369] 3 hSpCas9 negative selection 11162945
17600881 17600904 20 + 28162770 OCIAML5 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 0.13966581315240245 [174] [347] 1 hSpCas9 negative selection 11162946
17600739 17600762 20 - 28162770 OCIAML5 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -0.28100967216805894 [277] [412] -2 hSpCas9 negative selection 11162947
17600894 17600917 20 + 28162770 OCIAML5 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.45390289014954943 [257] [339] -3 hSpCas9 negative selection 11162948
17607124 17607147 20 - 28162770 OCIAML5 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 0.5042130288141423 [165] [424] 4 hSpCas9 negative selection 11162949
17607066 17607089 20 - 28162770 OCIAML5 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 1.11263637702271 [330] [1291] 8 hSpCas9 negative selection 11162950
17607137 17607160 20 - 28162770 EOL1 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 1.3080305369745333 [311] [406] 9 hSpCas9 negative selection 11332309
17604585 17604608 20 + 28162770 EOL1 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 1.3725625932956511 [172] [235] 9 hSpCas9 negative selection 11332310
17607061 17607084 20 + 28162770 EOL1 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 1.3643935644318805 [417] [566] 9 hSpCas9 negative selection 11332311
17600881 17600904 20 + 28162770 EOL1 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.05132943422929159 [770] [391] 0 hSpCas9 negative selection 11332312
17600739 17600762 20 - 28162770 EOL1 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -0.3856257336343256 [1038] [418] -3 hSpCas9 negative selection 11332313
17600894 17600917 20 + 28162770 EOL1 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 0.1135171913695322 [392] [223] 1 hSpCas9 negative selection 11332314
17607124 17607147 20 - 28162770 EOL1 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 0.6941180311686683 [209] [178] 6 hSpCas9 negative selection 11332315
17607066 17607089 20 - 28162770 EOL1 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.8095916648808044 [691] [638] 7 hSpCas9 negative selection 11332316
17607137 17607160 20 - 28162770 MOLM13 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.3458988571659683 [332] [305] 2 hSpCas9 negative selection 11501675
17604585 17604608 20 + 28162770 MOLM13 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.37263240444822465 [153] [85] -2 hSpCas9 negative selection 11501676
17607061 17607084 20 + 28162770 MOLM13 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.5518883674913467 [416] [441] 4 hSpCas9 negative selection 11501677
17600881 17600904 20 + 28162770 MOLM13 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -1.1256862494812854 [503] [166] -5 hSpCas9 negative selection 11501678
17600739 17600762 20 - 28162770 MOLM13 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -1.3830419631239639 [688] [190] -6 hSpCas9 negative selection 11501679
17600894 17600917 20 + 28162770 MOLM13 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -2.0904051687144976 [535] [90] -7 hSpCas9 negative selection 11501680
17607124 17607147 20 - 28162770 MOLM13 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 -0.7902628029094689 [353] [147] -4 hSpCas9 negative selection 11501681
17607066 17607089 20 - 28162770 MOLM13 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.3249314277025359 [900] [815] 2 hSpCas9 negative selection 11501682
17607137 17607160 20 - 28162770 HEL viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.3351142751424927 [275] [222] 2 hSpCas9 negative selection 11671041
17604585 17604608 20 + 28162770 HEL viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.9247741997642067 [87] [106] 7 hSpCas9 negative selection 11671042
17607061 17607084 20 + 28162770 HEL viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.8202217937189372 [274] [310] 7 hSpCas9 negative selection 11671043
17600881 17600904 20 + 28162770 HEL viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 0.11630240788565649 [470] [326] 0 hSpCas9 negative selection 11671044
17600739 17600762 20 - 28162770 HEL viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -0.037950603387415516 [661] [412] 0 hSpCas9 negative selection 11671045
17600894 17600917 20 + 28162770 HEL viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 0.5568780953465191 [449] [423] 5 hSpCas9 negative selection 11671046
17607124 17607147 20 - 28162770 HEL viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 0.24760089015921788 [191] [145] 2 hSpCas9 negative selection 11671047
17607066 17607089 20 - 28162770 HEL viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.6837175407473095 [832] [856] 6 hSpCas9 negative selection 11671048
17607137 17607160 20 - 28162770 MV411 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.3110961880050931 [132] [138] 2 hSpCas9 negative selection 11840407
17604585 17604608 20 + 28162770 MV411 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.21858268811059023 [100] [98] 2 hSpCas9 negative selection 11840408
17607061 17607084 20 + 28162770 MV411 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.6702945545209184 [275] [369] 6 hSpCas9 negative selection 11840409
17600881 17600904 20 + 28162770 MV411 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.46025312100791727 [373] [228] -3 hSpCas9 negative selection 11840410
17600739 17600762 20 - 28162770 MV411 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -0.8594776531337367 [559] [259] -5 hSpCas9 negative selection 11840411
17600894 17600917 20 + 28162770 MV411 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.5573706891644823 [282] [161] -4 hSpCas9 negative selection 11840412
17607124 17607147 20 - 28162770 MV411 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 0.695490107289582 [161] [220] 6 hSpCas9 negative selection 11840413
17607066 17607089 20 - 28162770 MV411 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.4858970936852518 [522] [616] 4 hSpCas9 negative selection 11840414
17607137 17607160 20 - 28162770 MONOMAC1 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.3421219640484775 [127] [185] 3 hSpCas9 negative selection 12009773
17604585 17604608 20 + 28162770 MONOMAC1 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.9348748284460274 [46] [102] 8 hSpCas9 negative selection 12009774
17607061 17607084 20 + 28162770 MONOMAC1 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.7005158839696287 [123] [230] 6 hSpCas9 negative selection 12009775
17600881 17600904 20 + 28162770 MONOMAC1 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 0.5064701054293546 [252] [411] 5 hSpCas9 negative selection 12009776
17600739 17600762 20 - 28162770 MONOMAC1 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 0.6509600594953964 [324] [584] 6 hSpCas9 negative selection 12009777
17600894 17600917 20 + 28162770 MONOMAC1 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.7687635206240158 [216] [145] -6 hSpCas9 negative selection 12009778
17607124 17607147 20 - 28162770 MONOMAC1 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 1.3527974302580006 [96] [283] 9 hSpCas9 negative selection 12009779
17607066 17607089 20 - 28162770 MONOMAC1 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 1.1222894526395284 [332] [830] 8 hSpCas9 negative selection 12009780
17607137 17607160 20 - 28162770 OCIAML2 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 -0.3048209322720808 [38] [174] -2 hSpCas9 negative selection 12179139
17604585 17604608 20 + 28162770 OCIAML2 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 -0.19264507794239583 [19] [96] -2 hSpCas9 negative selection 12179140
17607061 17607084 20 + 28162770 OCIAML2 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.7388235403867883 [55] [517] 7 hSpCas9 negative selection 12179141
17600881 17600904 20 + 28162770 OCIAML2 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.6452033302625391 [67] [240] -5 hSpCas9 negative selection 12179142
17600739 17600762 20 - 28162770 OCIAML2 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -0.1844057920364779 [89] [438] -1 hSpCas9 negative selection 12179143
17600894 17600917 20 + 28162770 OCIAML2 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 -0.6236106856110414 [81] [294] -5 hSpCas9 negative selection 12179144
17607124 17607147 20 - 28162770 OCIAML2 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 0.5142632823676304 [23] [189] 5 hSpCas9 negative selection 12179145
17607066 17607089 20 - 28162770 OCIAML2 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 0.0966306737455358 [122] [728] 0 hSpCas9 negative selection 12179146
17607137 17607160 20 - 28162770 OCIAML3 viability GGCACTGAATAATCTACACAGGG DSTN ENSG00000125868 0.6850649756014018 [40] [198] 6 hSpCas9 negative selection 12348505
17604585 17604608 20 + 28162770 OCIAML3 viability AATGATCTATGCAAGCTCCAAGG DSTN ENSG00000125868 0.90849270020502 [32] [186] 7 hSpCas9 negative selection 12348506
17607061 17607084 20 + 28162770 OCIAML3 viability ATGGACCAGAAGATCTCAATCGG DSTN ENSG00000125868 0.623897390019971 [68] [320] 5 hSpCas9 negative selection 12348507
17600881 17600904 20 + 28162770 OCIAML3 viability AGAAGAAGGCAAAGAGATCTTGG DSTN ENSG00000125868 -0.9279083768776016 [120] [191] -6 hSpCas9 negative selection 12348508
17600739 17600762 20 - 28162770 OCIAML3 viability ATCAGCTACTTGCACTCCTGAGG DSTN ENSG00000125868 -0.13564270938121892 [122] [337] -1 hSpCas9 negative selection 12348509
17600894 17600917 20 + 28162770 OCIAML3 viability GAGATCTTGGTTGGAGATGTTGG DSTN ENSG00000125868 0.5724283750382692 [91] [412] 5 hSpCas9 negative selection 12348510
17607124 17607147 20 - 28162770 OCIAML3 viability CTACACAGGGCATCCTTCAAAGG DSTN ENSG00000125868 -0.04445047573420566 [54] [160] 0 hSpCas9 negative selection 12348511
17607066 17607089 20 - 28162770 OCIAML3 viability CAAGCCCGATTGAGATCTTCTGG DSTN ENSG00000125868 1.043569486560415 [174] [1088] 8 hSpCas9 negative selection 12348512