Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 3667
• Symbol: IRS1
• Description: insulin receptor substrate 1

DataSource: http://genomecrispr.dkfz.de/#!/results/IRS1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
226796654	226796677	2	+	26472758	Jiyoye	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	-0.19427524200385188	[131]	[86]	-1	hSpCas9	negative selection	79272
226796719	226796742	2	+	26472758	Jiyoye	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	2.2200898289053783	[36]	[129]	9	hSpCas9	negative selection	79273
226798514	226798537	2	-	26472758	Jiyoye	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	-0.4732430027414539	[80]	[43]	-3	hSpCas9	negative selection	79274
226798447	226798470	2	-	26472758	Jiyoye	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	1.5624536069837842	[21]	[48]	8	hSpCas9	negative selection	79275
226798284	226798307	2	-	26472758	Jiyoye	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	-0.044387993798084224	[319]	[233]	0	hSpCas9	negative selection	79276
226798132	226798155	2	-	26472758	Jiyoye	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	-0.07469362625117915	[80]	[57]	0	hSpCas9	negative selection	79277
226797617	226797640	2	+	26472758	Jiyoye	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	-0.5470209288810017	[92]	[47]	-4	hSpCas9	negative selection	79278
226797557	226797580	2	+	26472758	Jiyoye	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	0.5540167698351444	[27]	[30]	4	hSpCas9	negative selection	79279
226797099	226797122	2	+	26472758	Jiyoye	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	0.05353842689117294	[45]	[35]	0	hSpCas9	negative selection	79280
226796996	226797019	2	+	26472758	Jiyoye	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-4.177787119215283	[23]	[0]	-9	hSpCas9	negative selection	79281
226796654	226796677	2	+	26472758	KBM7	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	0.3781803298965193	[301,244]	[162,168]	4	hSpCas9	negative selection	270390
226796719	226796742	2	+	26472758	KBM7	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	-0.06024764964363594	[390,305]	[184,129]	0	hSpCas9	negative selection	270391
226798514	226798537	2	-	26472758	KBM7	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	0.4250007664991537	[214,282]	[147,170]	4	hSpCas9	negative selection	270392
226798447	226798470	2	-	26472758	KBM7	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	0.2663327576267911	[248,135]	[150,65]	2	hSpCas9	negative selection	270393
226798284	226798307	2	-	26472758	KBM7	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.19275193961572157	[1382,830]	[636,533]	2	hSpCas9	negative selection	270394
226798132	226798155	2	-	26472758	KBM7	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	0.6571262662775889	[308,257]	[250,171]	7	hSpCas9	negative selection	270395
226797617	226797640	2	+	26472758	KBM7	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	-0.5811295777346608	[327,167]	[70,79]	-5	hSpCas9	negative selection	270396
226797557	226797580	2	+	26472758	KBM7	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	0.5130733668637535	[164,107]	[97,82]	5	hSpCas9	negative selection	270397
226797099	226797122	2	+	26472758	KBM7	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	0.049572311402018454	[318,266]	[198,90]	0	hSpCas9	negative selection	270398
226796996	226797019	2	+	26472758	KBM7	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-2.915905149363496	[161,136]	[3,13]	-9	hSpCas9	negative selection	270399
226796654	226796677	2	+	26472758	Raji	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	0.08454355901548802	[190]	[46]	0	hSpCas9	negative selection	461508
226796719	226796742	2	+	26472758	Raji	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	0.20381329805669213	[216]	[57]	2	hSpCas9	negative selection	461509
226798514	226798537	2	-	26472758	Raji	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	-0.5248846801259135	[92]	[14]	-4	hSpCas9	negative selection	461510
226798447	226798470	2	-	26472758	Raji	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	0.42931163026096164	[95]	[29]	4	hSpCas9	negative selection	461511
226798284	226798307	2	-	26472758	Raji	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.13300934304909395	[557]	[141]	1	hSpCas9	negative selection	461512
226798132	226798155	2	-	26472758	Raji	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	0.5571864528131201	[122]	[41]	5	hSpCas9	negative selection	461513
226797617	226797640	2	+	26472758	Raji	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	0.5619493988390807	[107]	[36]	5	hSpCas9	negative selection	461514
226797557	226797580	2	+	26472758	Raji	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	0.08501572234514487	[64]	[15]	0	hSpCas9	negative selection	461515
226797099	226797122	2	+	26472758	Raji	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	-0.06254146606871275	[170]	[37]	0	hSpCas9	negative selection	461516
226796996	226797019	2	+	26472758	Raji	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-1.9800793058767399	[67]	[3]	-8	hSpCas9	negative selection	461517
226796654	226796677	2	+	26472758	K562	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	0.018673539213574952	[358]	[306]	0	hSpCas9	negative selection	652626
226796719	226796742	2	+	26472758	K562	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	-0.6433400077638756	[308]	[166]	-4	hSpCas9	negative selection	652627
226798514	226798537	2	-	26472758	K562	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	1.2190758795519834	[200]	[394]	8	hSpCas9	negative selection	652628
226798447	226798470	2	-	26472758	K562	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	1.8065713454795171	[84]	[250]	9	hSpCas9	negative selection	652629
226798284	226798307	2	-	26472758	K562	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	-0.6000636947122664	[1229]	[684]	-4	hSpCas9	negative selection	652630
226798132	226798155	2	-	26472758	K562	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	-0.6358420280594574	[415]	[225]	-4	hSpCas9	negative selection	652631
226797617	226797640	2	+	26472758	K562	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	0.8081126116339519	[204]	[302]	6	hSpCas9	negative selection	652632
226797557	226797580	2	+	26472758	K562	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	-1.0143155407337217	[133]	[55]	-5	hSpCas9	negative selection	652633
226797099	226797122	2	+	26472758	K562	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	0.3762633836825082	[208]	[228]	3	hSpCas9	negative selection	652634
226796996	226797019	2	+	26472758	K562	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-6.30247573222119	[186]	[1]	-9	hSpCas9	negative selection	652635
226797395	226797418	2	+	26627737	DLD1	viability	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	-1.646654125774281	[711]	[113,47,52]	-8	hSpCas9	negative selection	810683
226798252	226798275	2	-	26627737	DLD1	viability	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-0.012259576328354616	[1541]	[601,504,347]	0	hSpCas9	negative selection	810684
226798690	226798713	2	-	26627737	DLD1	viability	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	0.5694166407214742	[714]	[568,234,205]	6	hSpCas9	negative selection	810685
226798708	226798731	2	+	26627737	DLD1	viability	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	0.32195158526384615	[206]	[33,95,108]	3	hSpCas9	negative selection	810686
226797395	226797418	2	+	26627737	GBM cells	viability after 5 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	-0.23333392341275405	[136]	[74,49]	-4	hSpCas9	negative selection	892998
226798252	226798275	2	-	26627737	GBM cells	viability after 5 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	0.06708398614581101	[913]	[485,540]	1	hSpCas9	negative selection	892999
226798690	226798713	2	-	26627737	GBM cells	viability after 5 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	-0.31875999754823253	[406]	[197,151]	-5	hSpCas9	negative selection	893000
226798708	226798731	2	+	26627737	GBM cells	viability after 5 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-1.0270855436705375	[113]	[22,36]	-9	hSpCas9	negative selection	893001
226797395	226797418	2	+	26627737	GBM cells	viability after 13 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	-0.6353932649598908	[136]	[27,63]	-6	hSpCas9	negative selection	975313
226798252	226798275	2	-	26627737	GBM cells	viability after 13 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-0.14841672139703022	[913]	[415,472]	-2	hSpCas9	negative selection	975314
226798690	226798713	2	-	26627737	GBM cells	viability after 13 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	-0.28254705472834707	[406]	[180,181]	-3	hSpCas9	negative selection	975315
226798708	226798731	2	+	26627737	GBM cells	viability after 13 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-1.070663204540561	[113]	[29,28]	-8	hSpCas9	negative selection	975316
226797395	226797418	2	+	26627737	GBM cells	viability after 21 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	-0.3860341163829655	[136]	[57,55]	-4	hSpCas9	negative selection	1057628
226798252	226798275	2	-	26627737	GBM cells	viability after 21 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	0.27798900398545134	[913]	[611,592]	3	hSpCas9	negative selection	1057629
226798690	226798713	2	-	26627737	GBM cells	viability after 21 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	-0.7157598495560206	[406]	[154,115]	-6	hSpCas9	negative selection	1057630
226798708	226798731	2	+	26627737	GBM cells	viability after 21 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-0.9708040612593427	[113]	[40,22]	-7	hSpCas9	negative selection	1057631
226797395	226797418	2	+	26627737	RPE1	viability after 9 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	0.7472282221258919	[372]	[171,226]	5	hSpCas9	negative selection	1139943
226798252	226798275	2	-	26627737	RPE1	viability after 9 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-0.04409630374752482	[2610]	[670,949]	0	hSpCas9	negative selection	1139944
226798690	226798713	2	-	26627737	RPE1	viability after 9 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	0.031376419483229556	[1887]	[700,478]	0	hSpCas9	negative selection	1139945
226798708	226798731	2	+	26627737	RPE1	viability after 9 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-1.5591220222557576	[809]	[82,89]	-8	hSpCas9	negative selection	1139946
226797395	226797418	2	+	26627737	RPE1	viability after 12 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	0.289549276289906	[372]	[121,122]	2	hSpCas9	negative selection	1222258
226798252	226798275	2	-	26627737	RPE1	viability after 12 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	0.08038884046252037	[2610]	[662,824]	0	hSpCas9	negative selection	1222259
226798690	226798713	2	-	26627737	RPE1	viability after 12 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	0.27851405390356354	[1887]	[793,425]	2	hSpCas9	negative selection	1222260
226798708	226798731	2	+	26627737	RPE1	viability after 12 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-1.4681608084482547	[809]	[66,90]	-7	hSpCas9	negative selection	1222261
226797395	226797418	2	+	26627737	RPE1	viability after 15 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	0.5858199647198502	[372]	[165,150]	3	hSpCas9	negative selection	1304573
226798252	226798275	2	-	26627737	RPE1	viability after 15 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	0.19433961331083616	[2610]	[726,958]	1	hSpCas9	negative selection	1304574
226798690	226798713	2	-	26627737	RPE1	viability after 15 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	0.7304197487853714	[1887]	[1133,646]	4	hSpCas9	negative selection	1304575
226798708	226798731	2	+	26627737	RPE1	viability after 15 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-2.5512831744972475	[809]	[33,43]	-8	hSpCas9	negative selection	1304576
226797395	226797418	2	+	26627737	RPE1	viability after 18 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	-0.014164322243634508	[372]	[133,62]	0	hSpCas9	negative selection	1386888
226798252	226798275	2	-	26627737	RPE1	viability after 18 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	0.2255911821075487	[2610]	[776,873]	1	hSpCas9	negative selection	1386889
226798690	226798713	2	-	26627737	RPE1	viability after 18 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	0.3008727323542624	[1887]	[748,497]	2	hSpCas9	negative selection	1386890
226798708	226798731	2	+	26627737	RPE1	viability after 18 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-1.4251865477856052	[809]	[92,68]	-7	hSpCas9	negative selection	1386891
226797395	226797418	2	+	26627737	HeLa	viability after 8 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	0.955119883334822	[144]	[169,18,183]	7	hSpCas9	negative selection	1469203
226798252	226798275	2	-	26627737	HeLa	viability after 8 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	0.2634273047471285	[1150]	[703,592,533]	2	hSpCas9	negative selection	1469204
226798690	226798713	2	-	26627737	HeLa	viability after 8 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	0.6606557782754985	[346]	[286,249,192]	5	hSpCas9	negative selection	1469205
226798708	226798731	2	+	26627737	HeLa	viability after 8 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	0.2093907535971994	[322]	[213,183,104]	2	hSpCas9	negative selection	1469206
226797395	226797418	2	+	26627737	HeLa	viability after 12 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	1.0514560682627165	[144]	[99,75,200]	7	hSpCas9	negative selection	1551518
226798252	226798275	2	-	26627737	HeLa	viability after 12 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	0.5908991556265053	[1150]	[1000,523,652]	5	hSpCas9	negative selection	1551519
226798690	226798713	2	-	26627737	HeLa	viability after 12 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	0.7946986946253118	[346]	[232,199,317]	6	hSpCas9	negative selection	1551520
226798708	226798731	2	+	26627737	HeLa	viability after 12 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-0.3056236632750566	[322]	[5,164,143]	-3	hSpCas9	negative selection	1551521
226797395	226797418	2	+	26627737	HeLa	viability after 15 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	0.6400015383122649	[144]	[71,126,75]	5	hSpCas9	negative selection	1633833
226798252	226798275	2	-	26627737	HeLa	viability after 15 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	0.08495440701316359	[1150]	[354,529,616]	0	hSpCas9	negative selection	1633834
226798690	226798713	2	-	26627737	HeLa	viability after 15 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	0.5765605397680178	[346]	[353,175,90]	5	hSpCas9	negative selection	1633835
226798708	226798731	2	+	26627737	HeLa	viability after 15 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-0.3627914861536951	[322]	[1,107,205]	-3	hSpCas9	negative selection	1633836
226797395	226797418	2	+	26627737	HeLa	viability after 18 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	0.5447071297127691	[144]	[40,99,75]	4	hSpCas9	negative selection	1716148
226798252	226798275	2	-	26627737	HeLa	viability after 18 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	0.07134544378260244	[1150]	[232,433,616]	0	hSpCas9	negative selection	1716149
226798690	226798713	2	-	26627737	HeLa	viability after 18 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	0.5513140369510685	[346]	[234,139,90]	4	hSpCas9	negative selection	1716150
226798708	226798731	2	+	26627737	HeLa	viability after 18 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-0.3489562523223984	[322]	[1,90,205]	-3	hSpCas9	negative selection	1716151
226797395	226797418	2	+	26627737	HCT116	viability after 6 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	-2.0163448714843977	[270]	[25,1]	-8	hSpCas9	negative selection	1798463
226798252	226798275	2	-	26627737	HCT116	viability after 6 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	0.39667854147357096	[1932]	[488,350]	2	hSpCas9	negative selection	1798464
226798690	226798713	2	-	26627737	HCT116	viability after 6 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	-0.6831795025859594	[1012]	[220,31]	-4	hSpCas9	negative selection	1798465
226798708	226798731	2	+	26627737	HCT116	viability after 6 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	0.9465766621261609	[241]	[4,110]	5	hSpCas9	negative selection	1798466
226797395	226797418	2	+	26627737	HCT116	viability after 8 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	0.5482827546523297	[153]	[120,108,141]	5	hSpCas9	negative selection	1880778
226798252	226798275	2	-	26627737	HCT116	viability after 8 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	0.15472141263966854	[820]	[468,355,682]	1	hSpCas9	negative selection	1880779
226798690	226798713	2	-	26627737	HCT116	viability after 8 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	0.5348096730121795	[308]	[181,320,235]	5	hSpCas9	negative selection	1880780
226798708	226798731	2	+	26627737	HCT116	viability after 8 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	0.28806383839450667	[74]	[45,29,74]	3	hSpCas9	negative selection	1880781
226797395	226797418	2	+	26627737	HCT116	viability after 9 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	-1.5183044623398858	[270]	[17,30]	-8	hSpCas9	negative selection	1963093
226798252	226798275	2	-	26627737	HCT116	viability after 9 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-0.34809403293495933	[1932]	[519,314]	-2	hSpCas9	negative selection	1963094
226798690	226798713	2	-	26627737	HCT116	viability after 9 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	0.006982562236289014	[1012]	[411,160]	0	hSpCas9	negative selection	1963095
226798708	226798731	2	+	26627737	HCT116	viability after 9 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-1.1354220158374388	[241]	[34,24]	-7	hSpCas9	negative selection	1963096
226797395	226797418	2	+	26627737	HCT116	viability after 12 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	-0.03326393131150818	[153]	[53,59,124]	0	hSpCas9	negative selection	2045408
226798252	226798275	2	-	26627737	HCT116	viability after 12 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	0.0772599359008832	[820]	[402,530,437]	0	hSpCas9	negative selection	2045409
226798690	226798713	2	-	26627737	HCT116	viability after 12 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	1.0166646755380864	[308]	[435,319,219]	8	hSpCas9	negative selection	2045410
226798708	226798731	2	+	26627737	HCT116	viability after 12 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	1.1801603431224106	[74]	[57,101,110]	8	hSpCas9	negative selection	2045411
226797395	226797418	2	+	26627737	HCT116	viability after 15 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	0.08001102664087612	[153]	[41,122,108]	0	hSpCas9	negative selection	2127723
226798252	226798275	2	-	26627737	HCT116	viability after 15 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-0.24077472330351202	[820]	[321,325,537]	-2	hSpCas9	negative selection	2127724
226798690	226798713	2	-	26627737	HCT116	viability after 15 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	0.23906781145492795	[308]	[223,188,216]	2	hSpCas9	negative selection	2127725
226798708	226798731	2	+	26627737	HCT116	viability after 15 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	0.6246012581253138	[74]	[50,50,94]	6	hSpCas9	negative selection	2127726
226797395	226797418	2	+	26627737	HCT116	viability after 18 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	0.5125353634426685	[153]	[59,121,136]	4	hSpCas9	negative selection	2210038
226798252	226798275	2	-	26627737	HCT116	viability after 18 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-0.040514977875830915	[820]	[346,339,477]	0	hSpCas9	negative selection	2210039
226798690	226798713	2	-	26627737	HCT116	viability after 18 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	-0.14168136652525276	[308]	[66,156,182]	-1	hSpCas9	negative selection	2210040
226798708	226798731	2	+	26627737	HCT116	viability after 18 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-0.18912999764789484	[74]	[24,20,50]	-2	hSpCas9	negative selection	2210041
226798596	226798619	2	+	24336569	HL60	viability	TCGTAGTACTCGAGGCGCGCCGG	IRS1	ENSG00000169047	0.433320906140144	[680]	[1945]	4	hSpCas9	negative selection	2272187
226798622	226798645	2	-	24336569	HL60	viability	TGCGCGCGGCCAGCGAGGCTGGG	IRS1	ENSG00000169047	0.8848050420585539	[713]	[2789]	7	hSpCas9	negative selection	2272188
226798627	226798650	2	-	24336569	HL60	viability	CGTACTGCGCGCGGCCAGCGAGG	IRS1	ENSG00000169047	-0.9644246794386768	[212]	[230]	-7	hSpCas9	negative selection	2272189
226798636	226798659	2	-	24336569	HL60	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.8455758368082253	[455]	[536]	-6	hSpCas9	negative selection	2272190
226798652	226798675	2	+	24336569	HL60	viability	GAAGCGTTTGTGCATGCTCTTGG	IRS1	ENSG00000169047	0.46859278514405833	[250]	[734]	4	hSpCas9	negative selection	2272191
226798663	226798686	2	+	24336569	HL60	viability	GCATGCTCTTGGGTTTGCGCAGG	IRS1	ENSG00000169047	-0.1579306364372931	[338]	[642]	-1	hSpCas9	negative selection	2272192
226798689	226798712	2	-	24336569	HL60	viability	TTCTCGGACGTGCGCAAGGTGGG	IRS1	ENSG00000169047	-0.44213589679119136	[650]	[1013]	-4	hSpCas9	negative selection	2272193
226798704	226798727	2	+	24336569	HL60	viability	TCCGAGAAGCCATCGCTCTCCGG	IRS1	ENSG00000169047	0.008733708342681945	[1394]	[2969]	0	hSpCas9	negative selection	2272194
226798713	226798736	2	-	24336569	HL60	viability	GCGAGCCCTCCGGAGAGCGATGG	IRS1	ENSG00000169047	1.392241648990519	[255]	[1421]	8	hSpCas9	negative selection	2272195
226798723	226798746	2	-	24336569	HL60	viability	TGGCAGCATGGCGAGCCCTCCGG	IRS1	ENSG00000169047	-1.0793747519061692	[689]	[690]	-7	hSpCas9	negative selection	2272196
226798596	226798619	2	+	24336569	KBM7	viability	TCGTAGTACTCGAGGCGCGCCGG	IRS1	ENSG00000169047	0.43674814921368255	[768]	[2838]	4	hSpCas9	negative selection	2339364
226798622	226798645	2	-	24336569	KBM7	viability	TGCGCGCGGCCAGCGAGGCTGGG	IRS1	ENSG00000169047	1.0684882229612063	[578]	[3311]	8	hSpCas9	negative selection	2339365
226798627	226798650	2	-	24336569	KBM7	viability	CGTACTGCGCGCGGCCAGCGAGG	IRS1	ENSG00000169047	-0.18375405622508856	[151]	[364]	-1	hSpCas9	negative selection	2339366
226798636	226798659	2	-	24336569	KBM7	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.5255016787541027	[283]	[1114]	5	hSpCas9	negative selection	2339367
226798652	226798675	2	+	24336569	KBM7	viability	GAAGCGTTTGTGCATGCTCTTGG	IRS1	ENSG00000169047	1.481218252270884	[121]	[928]	9	hSpCas9	negative selection	2339368
226798663	226798686	2	+	24336569	KBM7	viability	GCATGCTCTTGGGTTTGCGCAGG	IRS1	ENSG00000169047	-0.4872493419789036	[423]	[824]	-4	hSpCas9	negative selection	2339369
226798689	226798712	2	-	24336569	KBM7	viability	TTCTCGGACGTGCGCAAGGTGGG	IRS1	ENSG00000169047	0.9726311122906961	[260]	[1396]	8	hSpCas9	negative selection	2339370
226798704	226798727	2	+	24336569	KBM7	viability	TCCGAGAAGCCATCGCTCTCCGG	IRS1	ENSG00000169047	0.42545426094339156	[913]	[3347]	4	hSpCas9	negative selection	2339371
226798713	226798736	2	-	24336569	KBM7	viability	GCGAGCCCTCCGGAGAGCGATGG	IRS1	ENSG00000169047	0.6403630250151844	[353]	[1504]	6	hSpCas9	negative selection	2339372
226798723	226798746	2	-	24336569	KBM7	viability	TGGCAGCATGGCGAGCCCTCCGG	IRS1	ENSG00000169047	-0.18940071936848968	[619]	[1482]	-2	hSpCas9	negative selection	2339373
226766236	226766259	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCACTGCAATCTCTGCCTCCAAG	IRS1	ENSG00000169047	0.009160240507729789	[175,457]	[15,128]	0	dCas9-VP64	positive selection	2425880
226798927	226798950	2	-	25494202	A375	resistance to PLX-4720 (puromycin)	ACTCCGGTCGGGCTCTCTCCTGG	IRS1	ENSG00000169047	3.3080684711241144	[55,442]	[22,1123]	8	dCas9-VP64	positive selection	2438255
226798909	226798932	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGGACGCAGCTGCTGAGCCCAGG	IRS1	ENSG00000169047	0.3416278733716087	[50,2]	[10,1]	1	dCas9-VP64	positive selection	2438256
226798951	226798974	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	TTCGGGCGCTTCACGCCCGGCGG	IRS1	ENSG00000169047	-0.9437948675606447	[22,1]	[0,0]	-5	dCas9-VP64	positive selection	2438257
226766236	226766259	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCACTGCAATCTCTGCCTCCAAG	IRS1	ENSG00000169047	0.1118552473866502	[131,312]	[53,99]	0	dCas9-VP64	positive selection	2521135
226798927	226798950	2	-	25494202	A375	resistance to PLX-4720 (zeocin)	ACTCCGGTCGGGCTCTCTCCTGG	IRS1	ENSG00000169047	-0.6378238648134653	[115,162]	[40,16]	-6	dCas9-VP64	positive selection	2533510
226798909	226798932	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGGACGCAGCTGCTGAGCCCAGG	IRS1	ENSG00000169047	-0.014123269982883047	[83,63]	[22,23]	0	dCas9-VP64	positive selection	2533511
226798951	226798974	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	TTCGGGCGCTTCACGCCCGGCGG	IRS1	ENSG00000169047	0.4828955161724875	[26,31]	[14,10]	4	dCas9-VP64	positive selection	2533512
226794997	226795020	2	+	27013184	SW480	treatment with recombinant TRAIL	ATGTCCAGTTGAGCTACTGACGG	IRS1	ENSG00000169047	-0.24113634059349526	[211,229]	[34,144]	-1	hSpCas9	positive selection	2964144
226795005	226795028	2	+	27013184	SW480	treatment with recombinant TRAIL	TTGAGCTACTGACGGTCCTCTGG	IRS1	ENSG00000169047	0.7196817075195618	[121,239]	[88,175]	3	hSpCas9	positive selection	2964145
226795099	226795122	2	+	27013184	SW480	treatment with recombinant TRAIL	CGCTGCCCAGGGGTTGATGAGGG	IRS1	ENSG00000169047	-1.0734599783878667	[419,635]	[102,110]	-5	hSpCas9	positive selection	2964146
226796809	226796832	2	+	27013184	SW480	treatment with recombinant TRAIL	GTGGGGCAGATACGCTCTTGGGG	IRS1	ENSG00000169047	4.1935749145983126	[90,140]	[670,1221]	9	hSpCas9	positive selection	2964147
226795100	226795123	2	+	27013184	SW480	treatment with recombinant TRAIL	GCTGCCCAGGGGTTGATGAGGGG	IRS1	ENSG00000169047	-1.4352627155698716	[908,1075]	[176,128]	-6	hSpCas9	positive selection	2964148
226795101	226795124	2	+	27013184	SW480	treatment with recombinant TRAIL	CTGCCCAGGGGTTGATGAGGGGG	IRS1	ENSG00000169047	3.785940672894789	[1,1]	[1,25]	9	hSpCas9	positive selection	2964149
226795104	226795127	2	+	27013184	SW480	treatment with recombinant TRAIL	CCCAGGGGTTGATGAGGGGGTGG	IRS1	ENSG00000169047	-0.06741656633021703	[155,163]	[21,127]	0	hSpCas9	positive selection	2964150
226797391	226797414	2	+	27013184	SW480	treatment with recombinant TRAIL	GGGAATCCGGAGTGACACTGCGG	IRS1	ENSG00000169047	2.028534945548518	[353,490]	[773,674]	8	hSpCas9	positive selection	2964151
226795143	226795166	2	+	27013184	SW480	treatment with recombinant TRAIL	GGTTCAGGGGTGCACTCCTGAGG	IRS1	ENSG00000169047	-0.8667138440838155	[349,306]	[97,49]	-4	hSpCas9	positive selection	2964152
226797492	226797515	2	+	27013184	SW480	treatment with recombinant TRAIL	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	1.8471113065314424	[169,299]	[326,396]	7	hSpCas9	positive selection	2964153
226797493	226797516	2	+	27013184	SW480	treatment with recombinant TRAIL	CCGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	-1.2504756401760873	[452,572]	[56,141]	-5	hSpCas9	positive selection	2964154
226795144	226795167	2	+	27013184	SW480	treatment with recombinant TRAIL	GTTCAGGGGTGCACTCCTGAGGG	IRS1	ENSG00000169047	0.015410178517867967	[119,99]	[68,18]	0	hSpCas9	positive selection	2964155
226797512	226797535	2	+	27013184	SW480	treatment with recombinant TRAIL	TGGGAAGAGACAATCCGAGGTGG	IRS1	ENSG00000169047	1.8271669183739376	[242,399]	[337,685]	7	hSpCas9	positive selection	2964156
226795174	226795197	2	+	27013184	SW480	treatment with recombinant TRAIL	TGAAGTCCTTGACCAAATCCAGG	IRS1	ENSG00000169047	1.387640352943631	[297,386]	[269,541]	6	hSpCas9	positive selection	2964157
226797869	226797892	2	+	27013184	SW480	treatment with recombinant TRAIL	GTTGAGATGGTGCCGGCGCAGGG	IRS1	ENSG00000169047	0.4251184197413794	[310,411]	[139,301]	2	hSpCas9	positive selection	2964158
226795226	226795249	2	+	27013184	SW480	treatment with recombinant TRAIL	CCCAGCAGCCCCACACAGTTTGG	IRS1	ENSG00000169047	0.980937118653953	[401,455]	[286,471]	4	hSpCas9	positive selection	2964159
226795230	226795253	2	+	27013184	SW480	treatment with recombinant TRAIL	GCAGCCCCACACAGTTTGGCTGG	IRS1	ENSG00000169047	0.28820414833847074	[678,948]	[564,219]	1	hSpCas9	positive selection	2964160
226795238	226795261	2	+	27013184	SW480	treatment with recombinant TRAIL	ACACAGTTTGGCTGGCTCCTTGG	IRS1	ENSG00000169047	0.35157976578370687	[218,360]	[90,248]	1	hSpCas9	positive selection	2964161
226795028	226795051	2	+	27013184	SW480	treatment with recombinant TRAIL	CTGCTTCTGGAAACTGATGCTGG	IRS1	ENSG00000169047	1.6983650947265176	[275,371]	[441,455]	7	hSpCas9	positive selection	2964162
226798704	226798727	2	+	27013184	SW480	treatment with recombinant TRAIL	TCCGAGAAGCCATCGCTCTCCGG	IRS1	ENSG00000169047	1.2288127630699546	[198,238]	[300,103]	6	hSpCas9	positive selection	2964163
226798707	226798730	2	+	27013184	SW480	treatment with recombinant TRAIL	GAGAAGCCATCGCTCTCCGGAGG	IRS1	ENSG00000169047	0.019775727134802246	[441,735]	[239,268]	0	hSpCas9	positive selection	2964164
226798708	226798731	2	+	27013184	SW480	treatment with recombinant TRAIL	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-1.0826876472785956	[130,298]	[45,36]	-5	hSpCas9	positive selection	2964165
226795034	226795057	2	+	27013184	SW480	treatment with recombinant TRAIL	CTGGAAACTGATGCTGGCATAGG	IRS1	ENSG00000169047	-0.854758689086923	[370,305]	[85,74]	-4	hSpCas9	positive selection	2964166
226795057	226795080	2	+	27013184	SW480	treatment with recombinant TRAIL	CGCTTAAATCCTCACTTGAGCGG	IRS1	ENSG00000169047	2.282407597482203	[150,119]	[184,432]	8	hSpCas9	positive selection	2964167
226795726	226795749	2	+	27013184	SW480	treatment with recombinant TRAIL	AGGTGTCCACGTAGCTCTGACGG	IRS1	ENSG00000169047	1.1890232045388323	[255,750]	[552,360]	5	hSpCas9	positive selection	2964168
226795060	226795083	2	+	27013184	SW480	treatment with recombinant TRAIL	TTAAATCCTCACTTGAGCGGCGG	IRS1	ENSG00000169047	2.601516101757361	[1,1]	[3,6]	9	hSpCas9	positive selection	2964169
226795061	226795084	2	+	27013184	SW480	treatment with recombinant TRAIL	TAAATCCTCACTTGAGCGGCGGG	IRS1	ENSG00000169047	1.9193244386626347	[64,44]	[148,8]	8	hSpCas9	positive selection	2964170
226795064	226795087	2	+	27013184	SW480	treatment with recombinant TRAIL	ATCCTCACTTGAGCGGCGGGTGG	IRS1	ENSG00000169047	1.4657537063155246	[165,179]	[183,235]	6	hSpCas9	positive selection	2964171
226795087	226795110	2	+	27013184	SW480	treatment with recombinant TRAIL	AGCTGCTCTCACCGCTGCCCAGG	IRS1	ENSG00000169047	2.5691803591806366	[313,404]	[684,1230]	9	hSpCas9	positive selection	2964172
226795098	226795121	2	+	27013184	SW480	treatment with recombinant TRAIL	CCGCTGCCCAGGGGTTGATGAGG	IRS1	ENSG00000169047	1.480253717860789	[700,888]	[696,1302]	6	hSpCas9	positive selection	2964173
226798709	226798732	2	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-0.1928911019260411	[2,3]	[2,1]	-3	hSpCas9	positive selection	2995988
226796914	226796937	2	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGACAGCTCCACCCTCCACACGG	IRS1	ENSG00000169047	-0.8912413333446484	[3,3]	[2,0]	-8	hSpCas9	positive selection	2995989
226798224	226798247	2	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CAAGTGATCCTGAAGCCCAAGGG	IRS1	ENSG00000169047	0.2009485084798902	[4,4]	[4,3]	4	hSpCas9	positive selection	2995990
226798514	226798537	2	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	0.2155119312061591	[2,3]	[3,3]	4	hSpCas9	positive selection	2995991
226798709	226798732	2	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	1.7831270616336796	[2,2]	[2,10]	9	hSpCas9	positive selection	3063846
226796914	226796937	2	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGACAGCTCCACCCTCCACACGG	IRS1	ENSG00000169047	0.041544228567713705	[3,3]	[3,1]	0	hSpCas9	positive selection	3063847
226798224	226798247	2	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CAAGTGATCCTGAAGCCCAAGGG	IRS1	ENSG00000169047	0.20864801929272078	[4,4]	[3,3]	3	hSpCas9	positive selection	3063848
226798514	226798537	2	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	0.03024981708332844	[2,2]	[1,1]	0	hSpCas9	positive selection	3063849
226797492	226797515		+	24336571	A375	resistance to PLX after 7 days	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.03970185061905235	[10,8]	[10,8]	-1	hSpCas9	positive selection	3121614
226798636	226798659		-	24336571	A375	resistance to PLX after 7 days	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.3394495626855009	[13,13]	[9,10]	-8	hSpCas9	positive selection	3121615
226797492	226797515		+	24336571	A375	resistance to PLX after 14 days	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.5994929005359042	[7,7]	[5,5]	5	hSpCas9	positive selection	3179407
226798636	226798659		-	24336571	A375	resistance to PLX after 14 days	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.22657597032843052	[11,13]	[3,5]	-2	hSpCas9	positive selection	3179408
226797492	226797515		+	24336571	A375	viability after 7 days	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.1893872483129323	[8]	[10,8]	3	hSpCas9	negative selection	3237200
226798636	226798659		-	24336571	A375	viability after 7 days	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.3427081704222308	[10]	[13,13]	5	hSpCas9	negative selection	3237201
226797492	226797515		+	24336571	A375	viability after 14 days	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.07306347860189816	[8]	[7,7]	-1	hSpCas9	negative selection	3294993
226798636	226798659		-	24336571	A375	viability after 14 days	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.2895785458673248	[10]	[11,13]	4	hSpCas9	negative selection	3294994
226796173	226796196	2	-	27383988	293T	resistance to West Nile virus (flavivirus)	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-1.600654783681737	[463,463]	[0,0]	-9	hSpCas9	positive selection	3374649
226798043	226798066	2	-	27383988	293T	resistance to West Nile virus (flavivirus)	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	0.29925689191175353	[372,372]	[2,2]	1	hSpCas9	positive selection	3374650
226798588	226798611	2	+	27383988	293T	resistance to West Nile virus (flavivirus)	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.748298337748043	[256,256]	[0,0]	-5	hSpCas9	positive selection	3374651
226798708	226798731	2	+	26780180	HT29	viability (Avana library 4 designs)	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	2.69709203432203	[]	[]	8	hSpCas9	negative selection	3433377
226796914	226796937	2	-	26780180	HT29	viability (Avana library 4 designs)	AGACAGCTCCACCCTCCACACGG	IRS1	ENSG00000169047	1.43468151488521	[]	[]	5	hSpCas9	negative selection	3433378
226798224	226798247	2	-	26780180	HT29	viability (Avana library 4 designs)	CAAGTGATCCTGAAGCCCAAGGG	IRS1	ENSG00000169047	2.9979730723268	[]	[]	8	hSpCas9	negative selection	3433379
226798514	226798537	2	-	26780180	HT29	viability (Avana library 4 designs)	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	2.25830029829173	[]	[]	7	hSpCas9	negative selection	3433380
226796914	226796937	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGACAGCTCCACCCTCCACACGG	IRS1	ENSG00000169047	2.80806308614581	[]	[]	4	hSpCas9	negative selection	3519958
226798708	226798731	2	+	26780180	A375	viability (Avana lentiCRISPRv2)	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	3.66695350566004	[]	[]	6	hSpCas9	negative selection	3519959
226798224	226798247	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	CAAGTGATCCTGAAGCCCAAGGG	IRS1	ENSG00000169047	-0.461150615937371	[]	[]	0	hSpCas9	negative selection	3519960
226798514	226798537	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	-2.3417100772748	[]	[]	-3	hSpCas9	negative selection	3519961
226798577	226798600	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	ACGAGAACGAGAAGAAGTGGCGG	IRS1	ENSG00000169047	1.01814582769251	[]	[]	1	hSpCas9	negative selection	3519962
226797414	226797437	2	+	26780180	A375	viability (Avana lentiCRISPRv2)	AAGGAACTCCGGAAATCGCAGGG	IRS1	ENSG00000169047	-1.49364789891169	[]	[]	-2	hSpCas9	negative selection	3519963
226796914	226796937	2	-	26780180	A375	viability (Avana lentiGuide)	AGACAGCTCCACCCTCCACACGG	IRS1	ENSG00000169047	-0.0144458241576833	[]	[]	0	hSpCas9	negative selection	3628617
226798708	226798731	2	+	26780180	A375	viability (Avana lentiGuide)	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	0.37428183698058	[]	[]	0	hSpCas9	negative selection	3628618
226798224	226798247	2	-	26780180	A375	viability (Avana lentiGuide)	CAAGTGATCCTGAAGCCCAAGGG	IRS1	ENSG00000169047	0.923041543536605	[]	[]	1	hSpCas9	negative selection	3628619
226798514	226798537	2	-	26780180	A375	viability (Avana lentiGuide)	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	-7.5546508248837	[]	[]	-9	hSpCas9	negative selection	3628620
226798577	226798600	2	-	26780180	A375	viability (Avana lentiGuide)	ACGAGAACGAGAAGAAGTGGCGG	IRS1	ENSG00000169047	18.5105583824648	[]	[]	8	hSpCas9	negative selection	3628621
226797414	226797437	2	+	26780180	A375	viability (Avana lentiGuide)	AAGGAACTCCGGAAATCGCAGGG	IRS1	ENSG00000169047	-0.1605181179047	[]	[]	0	hSpCas9	negative selection	3628622
226796914	226796937	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGACAGCTCCACCCTCCACACGG	IRS1	ENSG00000169047	0.01571490459063364	[4]	[5,4]	0	hSpCas9	positive selection	3737276
226798708	226798731	2	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	0.13117275724081182	[5]	[5,5]	3	hSpCas9	positive selection	3737277
226798224	226798247	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CAAGTGATCCTGAAGCCCAAGGG	IRS1	ENSG00000169047	-0.27115193308724855	[6]	[5,3]	-4	hSpCas9	positive selection	3737278
226798514	226798537	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	-0.037610166491062164	[4]	[3,5]	0	hSpCas9	positive selection	3737279
226798577	226798600	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ACGAGAACGAGAAGAAGTGGCGG	IRS1	ENSG00000169047	-0.06925116055290598	[4]	[3,4]	-1	hSpCas9	positive selection	3737280
226797414	226797437	2	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AAGGAACTCCGGAAATCGCAGGG	IRS1	ENSG00000169047	-0.29373013250181523	[4]	[4,2]	-4	hSpCas9	positive selection	3737281
226796914	226796937	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGACAGCTCCACCCTCCACACGG	IRS1	ENSG00000169047	0.23905530148467707	[5]	[4,6]	6	hSpCas9	positive selection	3845883
226798708	226798731	2	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-0.27411931284231456	[4]	[2,3]	-4	hSpCas9	positive selection	3845884
226798224	226798247	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CAAGTGATCCTGAAGCCCAAGGG	IRS1	ENSG00000169047	0.10551891659796364	[6]	[7,4]	2	hSpCas9	positive selection	3845885
226798514	226798537	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	0.3540018567337314	[5]	[6,6]	9	hSpCas9	positive selection	3845886
226798577	226798600	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ACGAGAACGAGAAGAAGTGGCGG	IRS1	ENSG00000169047	-1.2711973432001598	[5]	[2,0]	-9	hSpCas9	positive selection	3845887
226797414	226797437	2	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AAGGAACTCCGGAAATCGCAGGG	IRS1	ENSG00000169047	0.17671027623525154	[5]	[5,3]	4	hSpCas9	positive selection	3845888
226797492	226797515	2	+	26780180	A375	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.995565259110183	[]	[]	4	hSpCas9	negative selection	3951902
226798636	226798659	2	-	26780180	A375	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.507774506346847	[]	[]	1	hSpCas9	negative selection	3951903
226798588	226798611	2	+	26780180	A375	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	1.07791699959749	[]	[]	5	hSpCas9	negative selection	3951904
226796173	226796196	2	-	26780180	A375	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	1.24967850986099	[]	[]	6	hSpCas9	negative selection	3951905
226798693	226798716	2	-	26780180	A375	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.737360842789922	[]	[]	2	hSpCas9	negative selection	3951906
226798043	226798066	2	-	26780180	A375	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	0.892462171298819	[]	[]	4	hSpCas9	negative selection	3951907
226797492	226797515	2	+	26780180	HT29	viability (GeCKOv2 library)	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	1.73026620735029	[]	[]	8	hSpCas9	negative selection	4059868
226798636	226798659	2	-	26780180	HT29	viability (GeCKOv2 library)	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	1.44951719065767	[]	[]	7	hSpCas9	negative selection	4059869
226798588	226798611	2	+	26780180	HT29	viability (GeCKOv2 library)	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	2.02590961328969	[]	[]	9	hSpCas9	negative selection	4059870
226796173	226796196	2	-	26780180	HT29	viability (GeCKOv2 library)	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	2.12034407920469	[]	[]	9	hSpCas9	negative selection	4059871
226798693	226798716	2	-	26780180	HT29	viability (GeCKOv2 library)	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	1.91198145945354	[]	[]	9	hSpCas9	negative selection	4059872
226798043	226798066	2	-	26780180	HT29	viability (GeCKOv2 library)	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	1.17812466911457	[]	[]	6	hSpCas9	negative selection	4059873
226797492	226797515	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.1770147018643254	[3]	[1,2]	4	hSpCas9	positive selection	4145316
226798636	226798659	2	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.03762808860712846	[3]	[1,2]	-1	hSpCas9	positive selection	4145317
226797492	226797515	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.4550037919024288	[2]	[0,0,3,0]	3	hSpCas9	positive selection	4209338
226798636	226798659	2	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.013009781276781374	[3]	[2,0,1,0]	0	hSpCas9	positive selection	4209339
226798636	226798659	2	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.16470649930880138	[3]	[4,2]	3	hSpCas9	positive selection	4277298
226797492	226797515	2	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.02076859549624943	[2]	[2,1]	0	hSpCas9	positive selection	4277299
226798693	226798716	2	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.3345917832426303	[2]	[2,2]	6	hSpCas9	positive selection	4277300
226796173	226796196	2	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.18863558353780396	[3]	[2,2]	-4	hSpCas9	positive selection	4341554
226798043	226798066	2	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	0.0732858556095709	[4]	[4,2]	1	hSpCas9	positive selection	4341555
226798588	226798611	2	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.2953589224242966	[3]	[3,0]	-6	hSpCas9	positive selection	4341556
226797494	226797516	2	+	27760321	OCIAML3	viability	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	0.349869932207314	[0,0]	[0,0]	4	hSpCas9	negative selection	4410329
226797740	226797762	2	+	27760321	OCIAML3	viability	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	-1.062096988231895	[9,1]	[2,0]	-7	hSpCas9	negative selection	4410330
226797819	226797841	2	+	27760321	OCIAML3	viability	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	0.06891511793777694	[1028,892]	[633,984]	0	hSpCas9	negative selection	4410331
226798043	226798065	2	-	27760321	OCIAML3	viability	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	0.45031118440219453	[921,828]	[756,1165]	5	hSpCas9	negative selection	4410332
226798269	226798291	2	-	27760321	OCIAML3	viability	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	0.20509543311106393	[699,642]	[504,735]	2	hSpCas9	negative selection	4410333
226797494	226797516	2	+	27760321	OCIAML2	viability	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	3.790714402927267	[0,0]	[18,0]	9	hSpCas9	negative selection	4493792
226797740	226797762	2	+	27760321	OCIAML2	viability	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	1.368008502638971	[9,1]	[7,16]	9	hSpCas9	negative selection	4493793
226797819	226797841	2	+	27760321	OCIAML2	viability	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	-0.09931840357124688	[1028,892]	[618,861]	-1	hSpCas9	negative selection	4493794
226798043	226798065	2	-	27760321	OCIAML2	viability	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	0.20581817862267782	[921,828]	[736,919]	2	hSpCas9	negative selection	4493795
226798269	226798291	2	-	27760321	OCIAML2	viability	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	0.40784138562519967	[699,642]	[682,769]	5	hSpCas9	negative selection	4493796
226797494	226797516	2	+	27760321	MV411	viability	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	0.5949485011219959	[0,0]	[0,0]	4	hSpCas9	negative selection	4577255
226797740	226797762	2	+	27760321	MV411	viability	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	3.006225523175977	[9,1]	[0,73]	9	hSpCas9	negative selection	4577256
226797819	226797841	2	+	27760321	MV411	viability	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	-0.19164492411979317	[1028,892]	[164,1137]	-1	hSpCas9	negative selection	4577257
226798043	226798065	2	-	27760321	MV411	viability	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	0.21049239884884519	[921,828]	[881,345]	1	hSpCas9	negative selection	4577258
226798269	226798291	2	-	27760321	MV411	viability	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	-0.531045482963447	[699,642]	[310,299]	-4	hSpCas9	negative selection	4577259
226797494	226797516	2	+	27760321	HL60	viability	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	0.2870783393278593	[0,0]	[0,0]	3	hSpCas9	negative selection	4660718
226797740	226797762	2	+	27760321	HL60	viability	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	-2.2169641660097295	[9,1]	[0,0]	-9	hSpCas9	negative selection	4660719
226797819	226797841	2	+	27760321	HL60	viability	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	0.3677457102301882	[1028,892]	[906,1119]	4	hSpCas9	negative selection	4660720
226798043	226798065	2	-	27760321	HL60	viability	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	0.520334948177446	[921,828]	[996,1053]	6	hSpCas9	negative selection	4660721
226798269	226798291	2	-	27760321	HL60	viability	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	0.05674061813389519	[699,642]	[600,537]	0	hSpCas9	negative selection	4660722
226797494	226797516	2	+	27760321	HT1080	viability	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	1.3056276939190559	[0,0]	[0,0]	7	hSpCas9	negative selection	4744181
226797740	226797762	2	+	27760321	HT1080	viability	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	0.30562769391905587	[1,1]	[0,0]	1	hSpCas9	negative selection	4744182
226797819	226797841	2	+	27760321	HT1080	viability	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	-1.2364160926269898	[892,696]	[79,193]	-5	hSpCas9	negative selection	4744183
226798043	226798065	2	-	27760321	HT1080	viability	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.420723693279623	[828,646]	[116,331]	-2	hSpCas9	negative selection	4744184
226798269	226798291	2	-	27760321	HT1080	viability	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	0.3954415375149505	[642,501]	[341,253]	2	hSpCas9	negative selection	4744185
226797494	226797516	2	+	27760321	HT29	viability after 7 days	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	-0.3840325596302083	[0,0]	[0,0,0]	-5	hSpCas9	negative selection	4827644
226797740	226797762	2	+	27760321	HT29	viability after 7 days	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	-1.3840325596302083	[1,1]	[0,0,0]	-9	hSpCas9	negative selection	4827645
226797819	226797841	2	+	27760321	HT29	viability after 7 days	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	-0.3099694166620792	[892,696]	[851,726,894]	-4	hSpCas9	negative selection	4827646
226798043	226798065	2	-	27760321	HT29	viability after 7 days	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	0.060968509970958484	[828,646]	[1116,1160,716]	0	hSpCas9	negative selection	4827647
226798269	226798291	2	-	27760321	HT29	viability after 7 days	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	-0.34070500234120904	[642,501]	[699,546,514]	-5	hSpCas9	negative selection	4827648
226797494	226797516	2	+	27760321	HT29	viability after 25 days	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	-0.21405457092746794	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	4911107
226797740	226797762	2	+	27760321	HT29	viability after 25 days	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	-0.1590551303721517	[1,1]	[3,0,0]	-2	hSpCas9	negative selection	4911108
226797819	226797841	2	+	27760321	HT29	viability after 25 days	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	-1.1690650513666487	[892,696]	[351,499,357]	-7	hSpCas9	negative selection	4911109
226798043	226798065	2	-	27760321	HT29	viability after 25 days	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-1.0829115160436609	[828,646]	[334,376,495]	-7	hSpCas9	negative selection	4911110
226798269	226798291	2	-	27760321	HT29	viability after 25 days	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	-0.8490672726555815	[642,501]	[499,367,194]	-6	hSpCas9	negative selection	4911111
226797494	226797516	2	+	27760321	HT29	viability after 22 days	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	-0.23137320278672746	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	4994570
226797740	226797762	2	+	27760321	HT29	viability after 22 days	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	-0.8218425018228093	[1,1]	[0,0,1]	-6	hSpCas9	negative selection	4994571
226797819	226797841	2	+	27760321	HT29	viability after 22 days	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	-1.0547009183053244	[892,696]	[553,355,413]	-7	hSpCas9	negative selection	4994572
226798043	226798065	2	-	27760321	HT29	viability after 22 days	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.9693613783990472	[828,646]	[352,356,600]	-6	hSpCas9	negative selection	4994573
226798269	226798291	2	-	27760321	HT29	viability after 22 days	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	-0.9924307915771	[642,501]	[319,379,297]	-6	hSpCas9	negative selection	4994574
226797494	226797516	2	+	27760321	HT29	viability after 19 days	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	-0.21553315036351428	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	5078033
226797740	226797762	2	+	27760321	HT29	viability after 19 days	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	-1.2155331503635143	[1,1]	[0,0,0]	-7	hSpCas9	negative selection	5078034
226797819	226797841	2	+	27760321	HT29	viability after 19 days	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	-0.9091078779942978	[892,696]	[459,701,294]	-6	hSpCas9	negative selection	5078035
226798043	226798065	2	-	27760321	HT29	viability after 19 days	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.7639351421998068	[828,646]	[433,708,346]	-6	hSpCas9	negative selection	5078036
226798269	226798291	2	-	27760321	HT29	viability after 19 days	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	-0.8333896043720808	[642,501]	[234,424,425]	-6	hSpCas9	negative selection	5078037
226797494	226797516	2	+	27760321	HT29	viability after 16 days	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	-0.1840686979425925	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	5161496
226797740	226797762	2	+	27760321	HT29	viability after 16 days	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	1.7834911440515224	[1,1]	[0,0,20]	9	hSpCas9	negative selection	5161497
226797819	226797841	2	+	27760321	HT29	viability after 16 days	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	-0.7319453778866739	[892,696]	[601,335,679]	-6	hSpCas9	negative selection	5161498
226798043	226798065	2	-	27760321	HT29	viability after 16 days	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.24496264719941785	[828,646]	[763,560,774]	-3	hSpCas9	negative selection	5161499
226798269	226798291	2	-	27760321	HT29	viability after 16 days	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	-0.3523192208830386	[642,501]	[437,582,475]	-4	hSpCas9	negative selection	5161500
226797494	226797516	2	+	27760321	HT29	viability after 13 days	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	-0.23635609738673047	[0,0]	[0,0,0]	-3	hSpCas9	negative selection	5244959
226797740	226797762	2	+	27760321	HT29	viability after 13 days	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	1.1671803574366715	[1,1]	[11,0,2]	9	hSpCas9	negative selection	5244960
226797819	226797841	2	+	27760321	HT29	viability after 13 days	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	-0.9728927111002523	[892,696]	[549,467,395]	-7	hSpCas9	negative selection	5244961
226798043	226798065	2	-	27760321	HT29	viability after 13 days	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.17456325688142926	[828,646]	[923,673,681]	-2	hSpCas9	negative selection	5244962
226798269	226798291	2	-	27760321	HT29	viability after 13 days	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	-0.5799936716963664	[642,501]	[509,536,294]	-6	hSpCas9	negative selection	5244963
226797494	226797516	2	+	27760321	HT29	viability after 10 days	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	-0.34236740454707437	[0,0]	[0,0,0]	-4	hSpCas9	negative selection	5328422
226797740	226797762	2	+	27760321	HT29	viability after 10 days	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	0.7719637484860886	[1,1]	[9,1,0]	9	hSpCas9	negative selection	5328423
226797819	226797841	2	+	27760321	HT29	viability after 10 days	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	-0.44739891182781955	[892,696]	[745,805,635]	-5	hSpCas9	negative selection	5328424
226798043	226798065	2	-	27760321	HT29	viability after 10 days	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.38561766140522624	[828,646]	[712,945,468]	-5	hSpCas9	negative selection	5328425
226798269	226798291	2	-	27760321	HT29	viability after 10 days	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	-1.0706452008519065	[642,501]	[413,348,259]	-8	hSpCas9	negative selection	5328426
226797494	226797516	2	+	27760321	MOLM13	viability	CGAAGCACTAGATCGCCGTGGG	IRS1	ENSG00000169047	0.8210053139495912	[0,0]	[0,0]	6	hSpCas9	negative selection	5411885
226797740	226797762	2	+	27760321	MOLM13	viability	TTCGCCGTCACTGGAGGCGCGG	IRS1	ENSG00000169047	-1.6830371913879976	[9,1]	[0,0]	-7	hSpCas9	negative selection	5411886
226797819	226797841	2	+	27760321	MOLM13	viability	CTCTCAGTGCGTGATCGGCGGG	IRS1	ENSG00000169047	1.1816113515619278	[1028,892]	[1135,1303]	8	hSpCas9	negative selection	5411887
226798043	226798065	2	-	27760321	MOLM13	viability	GGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	0.5678805699468883	[921,828]	[866,615]	4	hSpCas9	negative selection	5411888
226798269	226798291	2	-	27760321	MOLM13	viability	GCTACGGTGACGTGCCCCCAGG	IRS1	ENSG00000169047	0.3405236948450724	[699,642]	[551,417]	2	hSpCas9	negative selection	5411889
226799558	226799581	2	+	27661255	K562	viability	GGAGGGGACAAGGGCGAGAGGGG	IRS1	ENSG00000169047	-0.08371778726754425	[712,572]	[559,423]	-3	dCas9-KRAB	negative selection	5487235
226799747	226799770	2	+	27661255	K562	viability	GACCGCGCCGCCGTCTCACTCGG	IRS1	ENSG00000169047	0.0533430860370665	[360,453]	[310,357]	1	dCas9-KRAB	negative selection	5487236
226799398	226799421	2	-	27661255	K562	viability	GCTGCAGAGGACGCGCCCGCGGG	IRS1	ENSG00000169047	0.22918296753847145	[1071,1090]	[1095,940]	7	dCas9-KRAB	negative selection	5487237
226799420	226799443	2	-	27661255	K562	viability	GCCGAGATGGGCCCGGATGGGGG	IRS1	ENSG00000169047	0.015011856312128452	[606,680]	[589,457]	0	dCas9-KRAB	negative selection	5487238
226799739	226799762	2	-	27661255	K562	viability	GACGGCGGCGCGGTCGGAGGGGG	IRS1	ENSG00000169047	-0.42631352789161747	[905,809]	[604,430]	-7	dCas9-KRAB	negative selection	5487239
226798636	226798659	2	-	27260156	BXPC3	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.27891969764104463	[859]	[614,682,875,813]	-6	hSpCas9	negative selection	5549758
226797492	226797515	2	+	27260156	BXPC3	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.4125418136499567	[315]	[229,222,256,289]	-7	hSpCas9	negative selection	5549759
226798693	226798716	2	-	27260156	BXPC3	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.03660439352053396	[362]	[309,376,370,521]	0	hSpCas9	negative selection	5549760
226796173	226796196	2	-	27260156	BXPC3	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.1958790527287867	[950]	[979,871,822,764]	-4	hSpCas9	negative selection	5614014
226798043	226798066	2	-	27260156	BXPC3	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.48009547335118674	[1014]	[738,709,683,929]	-8	hSpCas9	negative selection	5614015
226798588	226798611	2	+	27260156	BXPC3	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.49645315510129473	[937]	[668,582,634,925]	-8	hSpCas9	negative selection	5614016
226798636	226798659	2	-	27260156	A673	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.04736091148974653	[859]	[1057,958,972,1013]	-1	hSpCas9	negative selection	5671009
226797492	226797515	2	+	27260156	A673	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.037046725366476685	[315]	[459,311,386,328]	-1	hSpCas9	negative selection	5671010
226798693	226798716	2	-	27260156	A673	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.14289875707939206	[362]	[511,470,419,527]	3	hSpCas9	negative selection	5671011
226796173	226796196	2	-	27260156	A673	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.01808266900915001	[950]	[1176,1107,997,1238]	0	hSpCas9	negative selection	5735265
226798043	226798066	2	-	27260156	A673	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.3988034534578544	[1014]	[1035,730,930,1020]	-7	hSpCas9	negative selection	5735266
226798588	226798611	2	+	27260156	A673	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.3520346625500562	[937]	[1051,823,861,806]	-7	hSpCas9	negative selection	5735267
226798636	226798659	2	-	27260156	A375	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.37149726571386577	[859]	[1337,1277,1254,1316]	5	hSpCas9	negative selection	5792260
226797492	226797515	2	+	27260156	A375	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.29384136714253106	[315]	[246,498,180,302]	-4	hSpCas9	negative selection	5792261
226798693	226798716	2	-	27260156	A375	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.3042454261179721	[362]	[381,695,642,407]	4	hSpCas9	negative selection	5792262
226796173	226796196	2	-	27260156	A375	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	0.06882114930410799	[950]	[805,1237,1637,1000]	1	hSpCas9	negative selection	5856516
226798043	226798066	2	-	27260156	A375	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.09479178123747123	[1014]	[1310,1216,883,1047]	-1	hSpCas9	negative selection	5856517
226798588	226798611	2	+	27260156	A375	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.26229560418365794	[937]	[705,1234,825,924]	-4	hSpCas9	negative selection	5856518
226798636	226798659	2	-	27260156	COLO741	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.17015221698634253	[859]	[1109,1336,1247]	3	hSpCas9	negative selection	5913511
226797492	226797515	2	+	27260156	COLO741	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.08043736291796216	[315]	[530,394,366]	1	hSpCas9	negative selection	5913512
226798693	226798716	2	-	27260156	COLO741	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.21215850582519669	[362]	[608,517,492]	4	hSpCas9	negative selection	5913513
226796173	226796196	2	-	27260156	COLO741	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.06482067170415995	[950]	[1124,1171,1180]	-1	hSpCas9	negative selection	5977767
226798043	226798066	2	-	27260156	COLO741	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.29265320203020395	[1014]	[1243,1119,841]	-6	hSpCas9	negative selection	5977768
226798588	226798611	2	+	27260156	COLO741	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.2467112078550484	[937]	[1099,1057,886]	-5	hSpCas9	negative selection	5977769
226798636	226798659	2	-	27260156	CAL120	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.01889641152995236	[859]	[1348,1069,876]	0	hSpCas9	negative selection	6034762
226797492	226797515	2	+	27260156	CAL120	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.2931902970710403	[315]	[391,243,336]	-4	hSpCas9	negative selection	6034763
226798693	226798716	2	-	27260156	CAL120	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.11311733575841815	[362]	[572,518,387]	1	hSpCas9	negative selection	6034764
226796173	226796196	2	-	27260156	CAL120	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	0.046262855231172795	[950]	[1528,1149,1035]	0	hSpCas9	negative selection	6099018
226798043	226798066	2	-	27260156	CAL120	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.17771759074646032	[1014]	[991,1010,1323]	-3	hSpCas9	negative selection	6099019
226798588	226798611	2	+	27260156	CAL120	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.5126826728593958	[937]	[973,879,626]	-6	hSpCas9	negative selection	6099020
226798636	226798659	2	-	27260156	CADOES1	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.12621499285186444	[859]	[790,952,907,838]	2	hSpCas9	negative selection	6156013
226797492	226797515	2	+	27260156	CADOES1	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.4864299555233005	[315]	[179,220,284,150]	-7	hSpCas9	negative selection	6156014
226798693	226798716	2	-	27260156	CADOES1	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	-0.0050363147023914645	[362]	[436,238,339,328]	0	hSpCas9	negative selection	6156015
226796173	226796196	2	-	27260156	CADOES1	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	0.06363086489069691	[950]	[939,1027,898,826]	1	hSpCas9	negative selection	6220269
226798043	226798066	2	-	27260156	CADOES1	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.4008367828847894	[1014]	[857,604,743,649]	-6	hSpCas9	negative selection	6220270
226798588	226798611	2	+	27260156	CADOES1	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.15275995133574805	[937]	[847,962,574,751]	-3	hSpCas9	negative selection	6220271
226798636	226798659	2	-	27260156	EWS502	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.2747022736658008	[859]	[590,712,611,1139]	-5	hSpCas9	negative selection	6277264
226797492	226797515	2	+	27260156	EWS502	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.7869486627580373	[315]	[166,213,246,146]	-8	hSpCas9	negative selection	6277265
226798693	226798716	2	-	27260156	EWS502	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.034931418627381305	[362]	[381,531,308,341]	0	hSpCas9	negative selection	6277266
226796173	226796196	2	-	27260156	EWS502	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.15463273790506227	[950]	[771,1068,913,867]	-3	hSpCas9	negative selection	6341520
226798043	226798066	2	-	27260156	EWS502	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.6872047929022373	[1014]	[511,722,676,780]	-8	hSpCas9	negative selection	6341521
226798588	226798611	2	+	27260156	EWS502	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.791569365705018	[937]	[599,555,448,692]	-8	hSpCas9	negative selection	6341522
226798636	226798659	2	-	27260156	EW8	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.1821160793814487	[859]	[802,710,1014,594]	3	hSpCas9	negative selection	6398515
226797492	226797515	2	+	27260156	EW8	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.12462512613944232	[315]	[311,222,201,215]	-2	hSpCas9	negative selection	6398516
226798693	226798716	2	-	27260156	EW8	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.32044271492055043	[362]	[499,321,324,342]	6	hSpCas9	negative selection	6398517
226796173	226796196	2	-	27260156	EW8	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	0.0016040652575664005	[950]	[1004,972,578,586]	0	hSpCas9	negative selection	6462771
226798043	226798066	2	-	27260156	EW8	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.32672426502556273	[1014]	[767,498,577,800]	-6	hSpCas9	negative selection	6462772
226798588	226798611	2	+	27260156	EW8	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.34485724312397603	[937]	[765,563,580,502]	-6	hSpCas9	negative selection	6462773
226798636	226798659	2	-	27260156	CORL105	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.15626451429027655	[859]	[1157,942,1361,1066]	3	hSpCas9	negative selection	6519766
226797492	226797515	2	+	27260156	CORL105	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.16769564911925539	[315]	[302,337,409,277]	-3	hSpCas9	negative selection	6519767
226798693	226798716	2	-	27260156	CORL105	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	-0.048231857006452106	[362]	[441,448,345,396]	-1	hSpCas9	negative selection	6519768
226796173	226796196	2	-	27260156	CORL105	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.1011729904148444	[950]	[734,966,1501,1010]	-2	hSpCas9	negative selection	6584022
226798043	226798066	2	-	27260156	CORL105	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	0.07322219024963617	[1014]	[1217,1133,1377,1290]	1	hSpCas9	negative selection	6584023
226798588	226798611	2	+	27260156	CORL105	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.4524150452626331	[937]	[685,1057,687,750]	-7	hSpCas9	negative selection	6584024
226798636	226798659	2	-	27260156	HS294T	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.16234108427122573	[859]	[283,285,322,295]	-2	hSpCas9	negative selection	6641017
226797492	226797515	2	+	27260156	HS294T	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.02738240428130123	[315]	[90,129,173,101]	0	hSpCas9	negative selection	6641018
226798693	226798716	2	-	27260156	HS294T	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.44428110031567086	[362]	[142,125,225,291]	6	hSpCas9	negative selection	6641019
226796173	226796196	2	-	27260156	HS294T	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.35608541737293253	[950]	[216,295,282,372]	-5	hSpCas9	negative selection	6705273
226798043	226798066	2	-	27260156	HS294T	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.04483080214975388	[1014]	[181,315,493,583]	0	hSpCas9	negative selection	6705274
226798588	226798611	2	+	27260156	HS294T	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.6965762521006305	[937]	[192,153,277,284]	-7	hSpCas9	negative selection	6705275
226798636	226798659	2	-	27260156	HCC44	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.5582284746916449	[859]	[654,561,972,518]	-7	hSpCas9	negative selection	6762268
226797492	226797515	2	+	27260156	HCC44	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.6599186016656631	[315]	[251,85,361,247]	-7	hSpCas9	negative selection	6762269
226798693	226798716	2	-	27260156	HCC44	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	-0.09821870434765412	[362]	[465,320,570,226]	-2	hSpCas9	negative selection	6762270
226796173	226796196	2	-	27260156	HCC44	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.18677532679805642	[950]	[1098,789,1088,857]	-3	hSpCas9	negative selection	6826524
226798043	226798066	2	-	27260156	HCC44	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.8976337877946866	[1014]	[589,668,645,551]	-8	hSpCas9	negative selection	6826525
226798588	226798611	2	+	27260156	HCC44	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-1.1764748197426058	[937]	[433,376,327,711]	-9	hSpCas9	negative selection	6826526
226798636	226798659	2	-	27260156	G402	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.01817920187036781	[859]	[1424,1228,978,596]	0	hSpCas9	negative selection	6883519
226797492	226797515	2	+	27260156	G402	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.15354965151008138	[315]	[195,529,297,349]	-2	hSpCas9	negative selection	6883520
226798693	226798716	2	-	27260156	G402	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.20615894671690904	[362]	[488,733,302,524]	2	hSpCas9	negative selection	6883521
226796173	226796196	2	-	27260156	G402	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.12161783662456005	[950]	[1569,880,781,1089]	-1	hSpCas9	negative selection	6947775
226798043	226798066	2	-	27260156	G402	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.45738522442074925	[1014]	[990,948,690,984]	-5	hSpCas9	negative selection	6947776
226798588	226798611	2	+	27260156	G402	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.42776133311614317	[937]	[847,692,1197,660]	-5	hSpCas9	negative selection	6947777
226798636	226798659	2	-	27260156	L33	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.003776193729637889	[859]	[922,330,575,800]	0	hSpCas9	negative selection	7004770
226797492	226797515	2	+	27260156	L33	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.19788857351813	[315]	[219,152,262,440]	4	hSpCas9	negative selection	7004771
226798693	226798716	2	-	27260156	L33	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.5036460743323744	[362]	[492,177,385,517]	8	hSpCas9	negative selection	7004772
226796173	226796196	2	-	27260156	L33	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.03025927546867191	[950]	[1057,395,535,844]	0	hSpCas9	negative selection	7069026
226798043	226798066	2	-	27260156	L33	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.23855114011891243	[1014]	[905,311,574,857]	-5	hSpCas9	negative selection	7069027
226798588	226798611	2	+	27260156	L33	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.6343453411232098	[937]	[708,225,377,552]	-9	hSpCas9	negative selection	7069028
226798636	226798659	2	-	27260156	K562	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.04337678012949908	[859]	[897,807,1010,472]	0	hSpCas9	negative selection	7126021
226797492	226797515	2	+	27260156	K562	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.47994445757379944	[315]	[66,293,269,169]	-5	hSpCas9	negative selection	7126022
226798693	226798716	2	-	27260156	K562	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.37512037130642467	[362]	[377,519,284,480]	5	hSpCas9	negative selection	7126023
226796173	226796196	2	-	27260156	K562	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.07876461369380194	[950]	[1201,459,952,614]	-1	hSpCas9	negative selection	7190277
226798043	226798066	2	-	27260156	K562	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.07467365653648583	[1014]	[941,955,780,761]	-1	hSpCas9	negative selection	7190278
226798588	226798611	2	+	27260156	K562	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.1936084878408405	[937]	[813,832,640,642]	-2	hSpCas9	negative selection	7190279
226798636	226798659	2	-	27260156	HT29	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.40117494050730723	[859]	[689,1076,856,579]	-6	hSpCas9	negative selection	7247272
226797492	226797515	2	+	27260156	HT29	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.3955040697352259	[315]	[368,269,238,291]	-6	hSpCas9	negative selection	7247273
226798693	226798716	2	-	27260156	HT29	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.0009648757117385887	[362]	[520,547,390,331]	0	hSpCas9	negative selection	7247274
226796173	226796196	2	-	27260156	HT29	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.3869075434937864	[950]	[1063,821,844,815]	-6	hSpCas9	negative selection	7311528
226798043	226798066	2	-	27260156	HT29	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.8385972961280355	[1014]	[717,508,793,716]	-8	hSpCas9	negative selection	7311529
226798588	226798611	2	+	27260156	HT29	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-1.0668711140923393	[937]	[543,534,697,411]	-9	hSpCas9	negative selection	7311530
226798636	226798659	2	-	27260156	MHHES1	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.2644349677983201	[859]	[969,958,843,533]	-5	hSpCas9	negative selection	7368523
226797492	226797515	2	+	27260156	MHHES1	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.6954099241201406	[315]	[343,233,189,140]	-8	hSpCas9	negative selection	7368524
226798693	226798716	2	-	27260156	MHHES1	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.2950028167602376	[362]	[521,578,465,449]	5	hSpCas9	negative selection	7368525
226796173	226796196	2	-	27260156	MHHES1	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.2444005504088469	[950]	[1164,990,903,638]	-4	hSpCas9	negative selection	7432779
226798043	226798066	2	-	27260156	MHHES1	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.24371194436471355	[1014]	[1054,1147,1133,615]	-4	hSpCas9	negative selection	7432780
226798588	226798611	2	+	27260156	MHHES1	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.3093467696964217	[937]	[897,785,1074,673]	-5	hSpCas9	negative selection	7432781
226798636	226798659	2	-	27260156	MEWO	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.09588678659193339	[859]	[882,667,732]	-2	hSpCas9	negative selection	7489774
226797492	226797515	2	+	27260156	MEWO	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.09107290800387868	[315]	[284,284,263]	-2	hSpCas9	negative selection	7489775
226798693	226798716	2	-	27260156	MEWO	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.30136359617771025	[362]	[455,352,453]	6	hSpCas9	negative selection	7489776
226796173	226796196	2	-	27260156	MEWO	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.015836532750358456	[950]	[1032,769,866]	0	hSpCas9	negative selection	7554030
226798043	226798066	2	-	27260156	MEWO	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.29759391892740295	[1014]	[819,732,773]	-6	hSpCas9	negative selection	7554031
226798588	226798611	2	+	27260156	MEWO	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.7504858632668644	[937]	[538,545,482]	-9	hSpCas9	negative selection	7554032
226798636	226798659	2	-	27260156	LNCAPCLONEFGC	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.22116189628275684	[859]	[918,735,1022,981]	3	hSpCas9	negative selection	7611025
226797492	226797515	2	+	27260156	LNCAPCLONEFGC	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.19034311641895535	[315]	[283,322,411,300]	3	hSpCas9	negative selection	7611026
226798693	226798716	2	-	27260156	LNCAPCLONEFGC	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.5128918247981884	[362]	[404,492,676,331]	7	hSpCas9	negative selection	7611027
226796173	226796196	2	-	27260156	LNCAPCLONEFGC	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	0.06468415247485915	[950]	[831,887,762,1101]	1	hSpCas9	negative selection	7675281
226798043	226798066	2	-	27260156	LNCAPCLONEFGC	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.07445937116786361	[1014]	[861,724,945,979]	-1	hSpCas9	negative selection	7675282
226798588	226798611	2	+	27260156	LNCAPCLONEFGC	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.007617470014663397	[937]	[910,875,932,669]	0	hSpCas9	negative selection	7675283
226798636	226798659	2	-	27260156	PANC0327	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.4140991860565145	[859]	[473,656,484,657]	-6	hSpCas9	negative selection	7732276
226797492	226797515	2	+	27260156	PANC0327	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.5125087918828304	[315]	[236,182,140,230]	-6	hSpCas9	negative selection	7732277
226798693	226798716	2	-	27260156	PANC0327	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	-0.557922083033981	[362]	[232,328,165,134]	-7	hSpCas9	negative selection	7732278
226796173	226796196	2	-	27260156	PANC0327	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.21443909214164047	[950]	[908,783,747,478]	-3	hSpCas9	negative selection	7796532
226798043	226798066	2	-	27260156	PANC0327	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.14921110960481698	[1014]	[655,1081,631,833]	-2	hSpCas9	negative selection	7796533
226798588	226798611	2	+	27260156	PANC0327	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.8504995326793883	[937]	[520,423,446,465]	-8	hSpCas9	negative selection	7796534
226798636	226798659	2	-	27260156	NCIH2009	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.38481688362675076	[859]	[970,875,922]	-5	hSpCas9	negative selection	7853527
226797492	226797515	2	+	27260156	NCIH2009	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.4210577005055294	[315]	[337,346,304]	-5	hSpCas9	negative selection	7853528
226798693	226798716	2	-	27260156	NCIH2009	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.282999101792081	[362]	[911,533,463]	4	hSpCas9	negative selection	7853529
226796173	226796196	2	-	27260156	NCIH2009	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	0.0243887302008714	[950]	[1736,1239,1152]	0	hSpCas9	negative selection	7917783
226798043	226798066	2	-	27260156	NCIH2009	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.4035832551183496	[1014]	[1192,976,1069]	-5	hSpCas9	negative selection	7917784
226798588	226798611	2	+	27260156	NCIH2009	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-1.1092137245141271	[937]	[605,670,542]	-8	hSpCas9	negative selection	7917785
226798636	226798659	2	-	27260156	NCIH1373	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.3412583713701941	[859]	[779,902,540,212]	-3	hSpCas9	negative selection	7974778
226797492	226797515	2	+	27260156	NCIH1373	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.3637979763600402	[315]	[173,168,417,87]	-4	hSpCas9	negative selection	7974779
226798693	226798716	2	-	27260156	NCIH1373	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.47307755191963985	[362]	[496,482,476,213]	4	hSpCas9	negative selection	7974780
226796173	226796196	2	-	27260156	NCIH1373	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	0.28358287567851836	[950]	[1653,1474,1061,266]	2	hSpCas9	negative selection	8039034
226798043	226798066	2	-	27260156	NCIH1373	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.29059688050071064	[1014]	[1678,993,626,132]	-3	hSpCas9	negative selection	8039035
226798588	226798611	2	+	27260156	NCIH1373	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.7615776391185571	[937]	[651,614,672,140]	-6	hSpCas9	negative selection	8039036
226798636	226798659	2	-	27260156	PATU8902	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.39652588117274656	[859]	[796,2055,1859,1510]	4	hSpCas9	negative selection	8096029
226797492	226797515	2	+	27260156	PATU8902	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.006292263484898752	[315]	[399,541,330,531]	0	hSpCas9	negative selection	8096030
226798693	226798716	2	-	27260156	PATU8902	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.23165236159315886	[362]	[764,221,693,667]	2	hSpCas9	negative selection	8096031
226796173	226796196	2	-	27260156	PATU8902	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	0.19880221106431262	[950]	[1651,1051,1152,2409]	2	hSpCas9	negative selection	8160285
226798043	226798066	2	-	27260156	PATU8902	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.31222242648270837	[1014]	[956,1423,651,1709]	-3	hSpCas9	negative selection	8160286
226798588	226798611	2	+	27260156	PATU8902	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.4275438620852251	[937]	[839,842,1017,1191]	-4	hSpCas9	negative selection	8160287
226798636	226798659	2	-	27260156	PANC1	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.24389935153334097	[859]	[537,747,695,543]	-4	hSpCas9	negative selection	8217280
226797492	226797515	2	+	27260156	PANC1	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.5230974427182609	[315]	[184,180,249,142]	-7	hSpCas9	negative selection	8217281
226798693	226798716	2	-	27260156	PANC1	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	-0.13912993978622384	[362]	[337,370,339,122]	-2	hSpCas9	negative selection	8217282
226796173	226796196	2	-	27260156	PANC1	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.12252176937661352	[950]	[718,1244,658,507]	-2	hSpCas9	negative selection	8281536
226798043	226798066	2	-	27260156	PANC1	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.3614402217129218	[1014]	[762,650,821,491]	-5	hSpCas9	negative selection	8281537
226798588	226798611	2	+	27260156	PANC1	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.6611945304948199	[937]	[587,615,367,480]	-7	hSpCas9	negative selection	8281538
226798636	226798659	2	-	27260156	PANC0813	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.30938579121481924	[859]	[746,815,832,854]	-5	hSpCas9	negative selection	8338531
226797492	226797515	2	+	27260156	PANC0813	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.793992225215792	[315]	[257,228,162,209]	-8	hSpCas9	negative selection	8338532
226798693	226798716	2	-	27260156	PANC0813	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	-0.06242434987752504	[362]	[513,399,387,343]	-1	hSpCas9	negative selection	8338533
226796173	226796196	2	-	27260156	PANC0813	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.41907992313308084	[950]	[933,1001,709,709]	-6	hSpCas9	negative selection	8402787
226798043	226798066	2	-	27260156	PANC0813	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.5621064829608781	[1014]	[1050,672,805,725]	-7	hSpCas9	negative selection	8402788
226798588	226798611	2	+	27260156	PANC0813	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-1.2897749871299529	[937]	[546,446,444,375]	-9	hSpCas9	negative selection	8402789
226798636	226798659	2	-	27260156	RDES	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.17571296969607753	[859]	[1012,917,1203,1383]	3	hSpCas9	negative selection	8459782
226797492	226797515	2	+	27260156	RDES	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.14206048664758059	[315]	[350,398,365,499]	2	hSpCas9	negative selection	8459783
226798693	226798716	2	-	27260156	RDES	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.5473956048655426	[362]	[421,656,748,640]	8	hSpCas9	negative selection	8459784
226796173	226796196	2	-	27260156	RDES	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	0.02096763372960897	[950]	[876,999,1188,1456]	0	hSpCas9	negative selection	8524038
226798043	226798066	2	-	27260156	RDES	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.5134848486044338	[1014]	[739,665,846,1061]	-7	hSpCas9	negative selection	8524039
226798588	226798611	2	+	27260156	RDES	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.6287657850302675	[937]	[565,693,746,809]	-8	hSpCas9	negative selection	8524040
226798636	226798659	2	-	27260156	PC3	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.17098104347296195	[859]	[575,758,1964,1047]	4	hSpCas9	negative selection	8581033
226797492	226797515	2	+	27260156	PC3	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.16516426653855237	[315]	[238,341,494,407]	3	hSpCas9	negative selection	8581034
226798693	226798716	2	-	27260156	PC3	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.14886807099693286	[362]	[407,286,467,410]	3	hSpCas9	negative selection	8581035
226796173	226796196	2	-	27260156	PC3	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.2296594091235553	[950]	[546,806,1437,712]	-5	hSpCas9	negative selection	8645289
226798043	226798066	2	-	27260156	PC3	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.4451468629017362	[1014]	[393,986,1044,737]	-7	hSpCas9	negative selection	8645290
226798588	226798611	2	+	27260156	PC3	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.5270749645535291	[937]	[568,425,920,752]	-8	hSpCas9	negative selection	8645291
226798636	226798659	2	-	27260156	PATU8988T	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.16179126910985553	[859]	[572,1027,908,1242]	2	hSpCas9	negative selection	8702284
226797492	226797515	2	+	27260156	PATU8988T	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.16458237111957508	[315]	[213,417,280,182]	-3	hSpCas9	negative selection	8702285
226798693	226798716	2	-	27260156	PATU8988T	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.05444526695785873	[362]	[327,409,410,306]	0	hSpCas9	negative selection	8702286
226796173	226796196	2	-	27260156	PATU8988T	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.30779321503247603	[950]	[820,621,994,496]	-5	hSpCas9	negative selection	8766540
226798043	226798066	2	-	27260156	PATU8988T	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.41896613021601525	[1014]	[544,777,1068,524]	-6	hSpCas9	negative selection	8766541
226798588	226798611	2	+	27260156	PATU8988T	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.5426609995469198	[937]	[451,915,523,625]	-7	hSpCas9	negative selection	8766542
226798636	226798659	2	-	27260156	T47D	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.05841192262615147	[859]	[979,1057,1139,989]	1	hSpCas9	negative selection	8823535
226797492	226797515	2	+	27260156	T47D	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.2730636818418485	[315]	[311,289,326,289]	-5	hSpCas9	negative selection	8823536
226798693	226798716	2	-	27260156	T47D	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.20711609559744282	[362]	[520,359,535,547]	4	hSpCas9	negative selection	8823537
226796173	226796196	2	-	27260156	T47D	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.012193339639387624	[950]	[1213,1091,1167,913]	0	hSpCas9	negative selection	8887791
226798043	226798066	2	-	27260156	T47D	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.5073269373127426	[1014]	[886,643,969,840]	-8	hSpCas9	negative selection	8887792
226798588	226798611	2	+	27260156	T47D	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.5834238534577088	[937]	[723,751,611,831]	-8	hSpCas9	negative selection	8887793
226798636	226798659	2	-	27260156	SU8686	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.14538754212179805	[859]	[840,810,890,1308]	2	hSpCas9	negative selection	8944786
226797492	226797515	2	+	27260156	SU8686	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.15873220015733924	[315]	[214,244,412,259]	-3	hSpCas9	negative selection	8944787
226798693	226798716	2	-	27260156	SU8686	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.36896678284623935	[362]	[429,336,589,533]	6	hSpCas9	negative selection	8944788
226796173	226796196	2	-	27260156	SU8686	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.12615142330413698	[950]	[530,706,1242,1070]	-2	hSpCas9	negative selection	9009042
226798043	226798066	2	-	27260156	SU8686	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.23955298727524488	[1014]	[693,823,864,1078]	-4	hSpCas9	negative selection	9009043
226798588	226798611	2	+	27260156	SU8686	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.5308584721183138	[937]	[566,627,585,827]	-7	hSpCas9	negative selection	9009044
226798636	226798659	2	-	27260156	SKES1	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.017150317815467053	[859]	[770,873,919,882]	0	hSpCas9	negative selection	9066037
226797492	226797515	2	+	27260156	SKES1	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.09158427695520827	[315]	[475,319,258,306]	2	hSpCas9	negative selection	9066038
226798693	226798716	2	-	27260156	SKES1	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.16721674028918304	[362]	[375,573,369,327]	3	hSpCas9	negative selection	9066039
226796173	226796196	2	-	27260156	SKES1	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.16046864751194412	[950]	[873,964,900,682]	-4	hSpCas9	negative selection	9130293
226798043	226798066	2	-	27260156	SKES1	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.3223936046160121	[1014]	[890,794,789,768]	-6	hSpCas9	negative selection	9130294
226798588	226798611	2	+	27260156	SKES1	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.34873019855869347	[937]	[780,998,570,632]	-6	hSpCas9	negative selection	9130295
226798636	226798659	2	-	27260156	TOV112D	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	0.20300886837685694	[859]	[972,1351,827,900]	4	hSpCas9	negative selection	9187288
226797492	226797515	2	+	27260156	TOV112D	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.24944604221974498	[315]	[473,509,277,285]	5	hSpCas9	negative selection	9187289
226798693	226798716	2	-	27260156	TOV112D	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.32150873767639354	[362]	[703,375,454,287]	6	hSpCas9	negative selection	9187290
226796173	226796196	2	-	27260156	TOV112D	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.05139449469340973	[950]	[1138,1136,835,642]	-1	hSpCas9	negative selection	9251544
226798043	226798066	2	-	27260156	TOV112D	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.37411366966439297	[1014]	[636,1191,607,786]	-6	hSpCas9	negative selection	9251545
226798588	226798611	2	+	27260156	TOV112D	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.3812005350555677	[937]	[868,746,644,643]	-6	hSpCas9	negative selection	9251546
226798636	226798659	2	-	27260156	TC71	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.019287789817182377	[859]	[882,915,813,1036]	0	hSpCas9	negative selection	9308539
226797492	226797515	2	+	27260156	TC71	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	0.06830173174678433	[315]	[371,312,293,448]	1	hSpCas9	negative selection	9308540
226798693	226798716	2	-	27260156	TC71	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.1734306408467963	[362]	[421,383,461,489]	4	hSpCas9	negative selection	9308541
226796173	226796196	2	-	27260156	TC71	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.12739705076305685	[950]	[1109,841,834,945]	-3	hSpCas9	negative selection	9372795
226798043	226798066	2	-	27260156	TC71	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.2849464916164407	[1014]	[823,1035,681,1047]	-6	hSpCas9	negative selection	9372796
226798588	226798611	2	+	27260156	TC71	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.2808609197463384	[937]	[663,891,874,884]	-6	hSpCas9	negative selection	9372797
226798636	226798659	2	-	27260156	TC32	viability	ACGCTTCTTCGTACTGCGCGCGG	IRS1	ENSG00000169047	-0.40241525380447046	[859]	[603,433,775,696]	-6	hSpCas9	negative selection	9429790
226797492	226797515	2	+	27260156	TC32	viability	ACCGAAGCACTAGATCGCCGTGG	IRS1	ENSG00000169047	-0.33527709008525486	[315]	[226,129,387,251]	-6	hSpCas9	negative selection	9429791
226798693	226798716	2	-	27260156	TC32	viability	TGGCTTCTCGGACGTGCGCAAGG	IRS1	ENSG00000169047	0.10470646948728646	[362]	[298,266,526,430]	2	hSpCas9	negative selection	9429792
226796173	226796196	2	-	27260156	TC32	viability	TGCTCAGACCAATAGCCGCCTGG	IRS1	ENSG00000169047	-0.08970643683628454	[950]	[799,698,1083,823]	-1	hSpCas9	negative selection	9494046
226798043	226798066	2	-	27260156	TC32	viability	TGGGCCGTTCTGCCGTGACGGGG	IRS1	ENSG00000169047	-0.3445459747464813	[1014]	[697,658,891,775]	-6	hSpCas9	negative selection	9494047
226798588	226798611	2	+	27260156	TC32	viability	TCTCGTTCTCGTAGTACTCGAGG	IRS1	ENSG00000169047	-0.6299048170340265	[937]	[547,397,727,671]	-8	hSpCas9	negative selection	9494048
226797395	226797418	2	+	27869803	HPAFII	viability after 27 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	1.0174356048555657	[115]	[159,92,NaN]	8	hSpCas9	negative selection	9573737
226798252	226798275	2	-	27869803	HPAFII	viability after 27 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-1.0483204133417845	[706]	[248,121,NaN]	-6	hSpCas9	negative selection	9573738
226798690	226798713	2	-	27869803	HPAFII	viability after 27 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	-1.1898654170329779	[399]	[149,43,NaN]	-7	hSpCas9	negative selection	9573739
226798708	226798731	2	+	27869803	HPAFII	viability after 27 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-4.323264542450177	[89]	[3,0,NaN]	-9	hSpCas9	negative selection	9573740
226797395	226797418	2	+	27869803	HPAFII	viability after 15 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	0.9492937711613519	[115]	[339,178,NaN]	9	hSpCas9	negative selection	9656186
226798252	226798275	2	-	27869803	HPAFII	viability after 15 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-0.43451127760883224	[706]	[753,442,NaN]	-5	hSpCas9	negative selection	9656187
226798690	226798713	2	-	27869803	HPAFII	viability after 15 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	-0.7920624934569376	[399]	[460,115,NaN]	-7	hSpCas9	negative selection	9656188
226798708	226798731	2	+	27869803	HPAFII	viability after 15 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-1.16046265516185	[89]	[99,7,NaN]	-8	hSpCas9	negative selection	9656189
226797395	226797418	2	+	27869803	ASPC1	viability after 36 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	-1.163464364515639	[436]	[91,83,37]	-8	hSpCas9	negative selection	9738635
226798252	226798275	2	-	27869803	ASPC1	viability after 36 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-0.5236110984829252	[2090]	[405,834,313]	-5	hSpCas9	negative selection	9738636
226798690	226798713	2	-	27869803	ASPC1	viability after 36 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	-0.6036469037635894	[1064]	[174,265,273]	-6	hSpCas9	negative selection	9738637
226798708	226798731	2	+	27869803	ASPC1	viability after 36 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-1.949579451733493	[408]	[16,77,17]	-9	hSpCas9	negative selection	9738638
226797395	226797418	2	+	27869803	PATU8988S	viability after 35 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	-1.723811086012069	[302]	[12,60,NaN]	-8	hSpCas9	negative selection	9821084
226798252	226798275	2	-	27869803	PATU8988S	viability after 35 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-0.5357471415303123	[1812]	[364,642,NaN]	-5	hSpCas9	negative selection	9821085
226798690	226798713	2	-	27869803	PATU8988S	viability after 35 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	-0.2510070124925378	[671]	[195,258,NaN]	-3	hSpCas9	negative selection	9821086
226798708	226798731	2	+	27869803	PATU8988S	viability after 35 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-0.2160041443384515	[211]	[77,68,NaN]	-2	hSpCas9	negative selection	9821087
226797395	226797418	2	+	27869803	PATU8988S	viability after 31 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	-2.1640018848913276	[302]	[22,31,NaN]	-9	hSpCas9	negative selection	9903533
226798252	226798275	2	-	27869803	PATU8988S	viability after 31 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-0.5110799890424929	[1812]	[468,555,NaN]	-5	hSpCas9	negative selection	9903534
226798690	226798713	2	-	27869803	PATU8988S	viability after 31 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	-0.288481213234725	[671]	[181,266,NaN]	-3	hSpCas9	negative selection	9903535
226798708	226798731	2	+	27869803	PATU8988S	viability after 31 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-0.3923832047262279	[211]	[81,41,NaN]	-4	hSpCas9	negative selection	9903536
226797395	226797418	2	+	27869803	HPAFII	viability after 35 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	0.7125703793126925	[115]	[91,100,NaN]	5	hSpCas9	negative selection	9985982
226798252	226798275	2	-	27869803	HPAFII	viability after 35 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-1.6344220428846656	[706]	[95,136,NaN]	-7	hSpCas9	negative selection	9985983
226798690	226798713	2	-	27869803	HPAFII	viability after 35 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	-0.7701159940697762	[399]	[185,42,NaN]	-4	hSpCas9	negative selection	9985984
226798708	226798731	2	+	27869803	HPAFII	viability after 35 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-2.6308957779681585	[89]	[12,0,NaN]	-8	hSpCas9	negative selection	9985985
226797395	226797418	2	+	27869803	HPAFII	viability after 31 days	ATCCGGAGTGACACTGCGGAAGG	IRS1	ENSG00000169047	0.4325951702287103	[115]	[95,78,NaN]	3	hSpCas9	negative selection	10068431
226798252	226798275	2	-	27869803	HPAFII	viability after 31 days	CCCAGGACCCGCATTCAAAGAGG	IRS1	ENSG00000169047	-1.3884771677126706	[706]	[163,137,NaN]	-7	hSpCas9	negative selection	10068432
226798690	226798713	2	-	27869803	HPAFII	viability after 31 days	CTTCTCGGACGTGCGCAAGGTGG	IRS1	ENSG00000169047	-1.6444295351188063	[399]	[100,39,NaN]	-7	hSpCas9	negative selection	10068433
226798708	226798731	2	+	27869803	HPAFII	viability after 31 days	AGAAGCCATCGCTCTCCGGAGGG	IRS1	ENSG00000169047	-3.053055293373545	[89]	[7,3,NaN]	-9	hSpCas9	negative selection	10068434
226796654	226796677	2	+	28162770	P31FUJ	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	0.36609948726465147	[102]	[155]	4	hSpCas9	negative selection	10175803
226796719	226796742	2	+	28162770	P31FUJ	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	0.6641043026215178	[260]	[485]	7	hSpCas9	negative selection	10175804
226798514	226798537	2	-	28162770	P31FUJ	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	0.06527914851861605	[121]	[149]	0	hSpCas9	negative selection	10175805
226798447	226798470	2	-	28162770	P31FUJ	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	0.11986941390409189	[64]	[82]	1	hSpCas9	negative selection	10175806
226798284	226798307	2	-	28162770	P31FUJ	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.4521272043672211	[445]	[716]	5	hSpCas9	negative selection	10175807
226798132	226798155	2	-	28162770	P31FUJ	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	-0.14974646468682007	[134]	[142]	-1	hSpCas9	negative selection	10175808
226797617	226797640	2	+	28162770	P31FUJ	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	0.6333420488508308	[78]	[143]	7	hSpCas9	negative selection	10175809
226797557	226797580	2	+	28162770	P31FUJ	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	-0.08470356542524482	[73]	[81]	-1	hSpCas9	negative selection	10175810
226797099	226797122	2	+	28162770	P31FUJ	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	0.31598668375329264	[174]	[255]	3	hSpCas9	negative selection	10175811
226796996	226797019	2	+	28162770	P31FUJ	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-2.437916634318991	[82]	[17]	-8	hSpCas9	negative selection	10175812
226796654	226796677	2	+	28162770	TF1	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	NaN	[NaN]	[60]	1	hSpCas9	negative selection	10345169
226796719	226796742	2	+	28162770	TF1	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	NaN	[NaN]	[254]	1	hSpCas9	negative selection	10345170
226798514	226798537	2	-	28162770	TF1	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	NaN	[NaN]	[111]	1	hSpCas9	negative selection	10345171
226798447	226798470	2	-	28162770	TF1	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	NaN	[NaN]	[93]	1	hSpCas9	negative selection	10345172
226798284	226798307	2	-	28162770	TF1	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	NaN	[NaN]	[322]	1	hSpCas9	negative selection	10345173
226798132	226798155	2	-	28162770	TF1	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	NaN	[NaN]	[142]	1	hSpCas9	negative selection	10345174
226797617	226797640	2	+	28162770	TF1	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	NaN	[NaN]	[76]	1	hSpCas9	negative selection	10345175
226797557	226797580	2	+	28162770	TF1	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	NaN	[NaN]	[106]	1	hSpCas9	negative selection	10345176
226797099	226797122	2	+	28162770	TF1	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	NaN	[NaN]	[132]	1	hSpCas9	negative selection	10345177
226796996	226797019	2	+	28162770	TF1	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	NaN	[NaN]	[5]	1	hSpCas9	negative selection	10345178
226796654	226796677	2	+	28162770	SKM1	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	1.1144331732005281	[28]	[110]	9	hSpCas9	negative selection	10514535
226796719	226796742	2	+	28162770	SKM1	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	-0.9708650839364883	[50]	[45]	-6	hSpCas9	negative selection	10514536
226798514	226798537	2	-	28162770	SKM1	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	-0.6844981742720708	[19]	[21]	-5	hSpCas9	negative selection	10514537
226798447	226798470	2	-	28162770	SKM1	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	-0.10579466402259685	[27]	[45]	-1	hSpCas9	negative selection	10514538
226798284	226798307	2	-	28162770	SKM1	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.7333876873158036	[114]	[337]	7	hSpCas9	negative selection	10514539
226798132	226798155	2	-	28162770	SKM1	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	0.1432328838173179	[41]	[81]	1	hSpCas9	negative selection	10514540
226797617	226797640	2	+	28162770	SKM1	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	-0.48942635893513464	[26]	[33]	-4	hSpCas9	negative selection	10514541
226797557	226797580	2	+	28162770	SKM1	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	0.7305393250067733	[14]	[43]	7	hSpCas9	negative selection	10514542
226797099	226797122	2	+	28162770	SKM1	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	-0.11346451218231668	[40]	[66]	-1	hSpCas9	negative selection	10514543
226796996	226797019	2	+	28162770	SKM1	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-1.7288922936305238	[14]	[7]	-8	hSpCas9	negative selection	10514544
226796654	226796677	2	+	28162770	SKM1	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	1.1144331732005281	[28]	[110]	9	hSpCas9	negative selection	10683901
226796719	226796742	2	+	28162770	SKM1	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	-0.9708650839364883	[50]	[45]	-6	hSpCas9	negative selection	10683902
226798514	226798537	2	-	28162770	SKM1	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	-0.6844981742720708	[19]	[21]	-5	hSpCas9	negative selection	10683903
226798447	226798470	2	-	28162770	SKM1	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	-0.10579466402259685	[27]	[45]	-1	hSpCas9	negative selection	10683904
226798284	226798307	2	-	28162770	SKM1	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.7333876873158036	[114]	[337]	7	hSpCas9	negative selection	10683905
226798132	226798155	2	-	28162770	SKM1	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	0.1432328838173179	[41]	[81]	1	hSpCas9	negative selection	10683906
226797617	226797640	2	+	28162770	SKM1	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	-0.48942635893513464	[26]	[33]	-4	hSpCas9	negative selection	10683907
226797557	226797580	2	+	28162770	SKM1	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	0.7305393250067733	[14]	[43]	7	hSpCas9	negative selection	10683908
226797099	226797122	2	+	28162770	SKM1	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	-0.11346451218231668	[40]	[66]	-1	hSpCas9	negative selection	10683909
226796996	226797019	2	+	28162770	SKM1	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-1.7288922936305238	[14]	[7]	-8	hSpCas9	negative selection	10683910
226796654	226796677	2	+	28162770	PL21	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	0.17157046229254935	[101]	[49]	1	hSpCas9	negative selection	10853267
226796719	226796742	2	+	28162770	PL21	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	-0.5452875584250824	[170]	[50]	-4	hSpCas9	negative selection	10853268
226798514	226798537	2	-	28162770	PL21	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	0.12537184608734786	[98]	[46]	1	hSpCas9	negative selection	10853269
226798447	226798470	2	-	28162770	PL21	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	0.1583194387946929	[69]	[33]	1	hSpCas9	negative selection	10853270
226798284	226798307	2	-	28162770	PL21	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.1968792853257333	[442]	[220]	1	hSpCas9	negative selection	10853271
226798132	226798155	2	-	28162770	PL21	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	1.5306128185096912	[100]	[126]	9	hSpCas9	negative selection	10853272
226797617	226797640	2	+	28162770	PL21	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	-2.8873232267610196	[67]	[3]	-9	hSpCas9	negative selection	10853273
226797557	226797580	2	+	28162770	PL21	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	-1.0893670027056648	[43]	[8]	-6	hSpCas9	negative selection	10853274
226797099	226797122	2	+	28162770	PL21	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	0.08040037021522473	[112]	[51]	0	hSpCas9	negative selection	10853275
226796996	226797019	2	+	28162770	PL21	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-1.5368259796768862	[39]	[5]	-7	hSpCas9	negative selection	10853276
226796654	226796677	2	+	28162770	P31FUJ	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	0.36609948726465147	[102]	[155]	4	hSpCas9	negative selection	11022633
226796719	226796742	2	+	28162770	P31FUJ	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	0.6641043026215178	[260]	[485]	7	hSpCas9	negative selection	11022634
226798514	226798537	2	-	28162770	P31FUJ	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	0.06527914851861605	[121]	[149]	0	hSpCas9	negative selection	11022635
226798447	226798470	2	-	28162770	P31FUJ	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	0.11986941390409189	[64]	[82]	1	hSpCas9	negative selection	11022636
226798284	226798307	2	-	28162770	P31FUJ	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.4521272043672211	[445]	[716]	5	hSpCas9	negative selection	11022637
226798132	226798155	2	-	28162770	P31FUJ	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	-0.14974646468682007	[134]	[142]	-1	hSpCas9	negative selection	11022638
226797617	226797640	2	+	28162770	P31FUJ	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	0.6333420488508308	[78]	[143]	7	hSpCas9	negative selection	11022639
226797557	226797580	2	+	28162770	P31FUJ	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	-0.08470356542524482	[73]	[81]	-1	hSpCas9	negative selection	11022640
226797099	226797122	2	+	28162770	P31FUJ	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	0.31598668375329264	[174]	[255]	3	hSpCas9	negative selection	11022641
226796996	226797019	2	+	28162770	P31FUJ	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-2.437916634318991	[82]	[17]	-8	hSpCas9	negative selection	11022642
226796654	226796677	2	+	28162770	OCIAML5	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	0.5534481542963403	[56]	[150]	5	hSpCas9	negative selection	11191999
226796719	226796742	2	+	28162770	OCIAML5	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	-0.5634404511274622	[148]	[181]	-4	hSpCas9	negative selection	11192000
226798514	226798537	2	-	28162770	OCIAML5	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	-1.093074670367792	[77]	[65]	-6	hSpCas9	negative selection	11192001
226798447	226798470	2	-	28162770	OCIAML5	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	0.5335871216337524	[30]	[80]	4	hSpCas9	negative selection	11192002
226798284	226798307	2	-	28162770	OCIAML5	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.37134076084908585	[202]	[473]	3	hSpCas9	negative selection	11192003
226798132	226798155	2	-	28162770	OCIAML5	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	0.42095192354241884	[47]	[115]	3	hSpCas9	negative selection	11192004
226797617	226797640	2	+	28162770	OCIAML5	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	0.18298037623520402	[60]	[124]	1	hSpCas9	negative selection	11192005
226797557	226797580	2	+	28162770	OCIAML5	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	-0.9493637722189121	[45]	[42]	-5	hSpCas9	negative selection	11192006
226797099	226797122	2	+	28162770	OCIAML5	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	0.8614801359185721	[117]	[386]	7	hSpCas9	negative selection	11192007
226796996	226797019	2	+	28162770	OCIAML5	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-3.4100620239848842	[52]	[8]	-9	hSpCas9	negative selection	11192008
226796654	226796677	2	+	28162770	EOL1	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	1.1634865017868652	[160]	[189]	8	hSpCas9	negative selection	11361365
226796719	226796742	2	+	28162770	EOL1	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	-1.018868700063098	[249]	[64]	-6	hSpCas9	negative selection	11361366
226798514	226798537	2	-	28162770	EOL1	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	-0.5507902379761235	[227]	[81]	-4	hSpCas9	negative selection	11361367
226798447	226798470	2	-	28162770	EOL1	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	0.2986134897930721	[124]	[80]	2	hSpCas9	negative selection	11361368
226798284	226798307	2	-	28162770	EOL1	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.5251258852012985	[826]	[626]	5	hSpCas9	negative selection	11361369
226798132	226798155	2	-	28162770	EOL1	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	-0.3155862321531805	[299]	[126]	-2	hSpCas9	negative selection	11361370
226797617	226797640	2	+	28162770	EOL1	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	-0.49048972770830934	[87]	[32]	-4	hSpCas9	negative selection	11361371
226797557	226797580	2	+	28162770	EOL1	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	-2.2307304539073765	[97]	[10]	-8	hSpCas9	negative selection	11361372
226797099	226797122	2	+	28162770	EOL1	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	0.06205129532046938	[159]	[87]	0	hSpCas9	negative selection	11361373
226796996	226797019	2	+	28162770	EOL1	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-5.360854447291714	[77]	[0]	-9	hSpCas9	negative selection	11361374
226796654	226796677	2	+	28162770	MOLM13	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	0.5413515434855999	[133]	[140]	4	hSpCas9	negative selection	11530731
226796719	226796742	2	+	28162770	MOLM13	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	-0.0769159927045946	[247]	[169]	0	hSpCas9	negative selection	11530732
226798514	226798537	2	-	28162770	MOLM13	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	0.8062119146826099	[139]	[176]	6	hSpCas9	negative selection	11530733
226798447	226798470	2	-	28162770	MOLM13	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	0.7750708910627547	[117]	[145]	6	hSpCas9	negative selection	11530734
226798284	226798307	2	-	28162770	MOLM13	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.7418303957004797	[592]	[716]	5	hSpCas9	negative selection	11530735
226798132	226798155	2	-	28162770	MOLM13	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	1.5527782791310916	[197]	[419]	9	hSpCas9	negative selection	11530736
226797617	226797640	2	+	28162770	MOLM13	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	0.12908746809282023	[128]	[101]	0	hSpCas9	negative selection	11530737
226797557	226797580	2	+	28162770	MOLM13	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	1.695490093883788	[78]	[184]	9	hSpCas9	negative selection	11530738
226797099	226797122	2	+	28162770	MOLM13	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	-0.17455861383733762	[127]	[81]	-1	hSpCas9	negative selection	11530739
226796996	226797019	2	+	28162770	MOLM13	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-5.023963714785096	[44]	[0]	-9	hSpCas9	negative selection	11530740
226796654	226796677	2	+	28162770	HEL	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	1.1378699224924473	[126]	[178]	8	hSpCas9	negative selection	11700097
226796719	226796742	2	+	28162770	HEL	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	0.3573366131381087	[233]	[191]	3	hSpCas9	negative selection	11700098
226798514	226798537	2	-	28162770	HEL	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	0.2374823535140987	[146]	[110]	2	hSpCas9	negative selection	11700099
226798447	226798470	2	-	28162770	HEL	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	1.2664337272102277	[97]	[150]	9	hSpCas9	negative selection	11700100
226798284	226798307	2	-	28162770	HEL	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.3529375166037776	[543]	[444]	3	hSpCas9	negative selection	11700101
226798132	226798155	2	-	28162770	HEL	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	0.2413762696185897	[139]	[105]	2	hSpCas9	negative selection	11700102
226797617	226797640	2	+	28162770	HEL	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	0.793417744498025	[108]	[120]	7	hSpCas9	negative selection	11700103
226797557	226797580	2	+	28162770	HEL	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	-1.1569625175138116	[93]	[26]	-6	hSpCas9	negative selection	11700104
226797099	226797122	2	+	28162770	HEL	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	0.48478647222412047	[134]	[120]	4	hSpCas9	negative selection	11700105
226796996	226797019	2	+	28162770	HEL	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-4.849114264329318	[44]	[0]	-9	hSpCas9	negative selection	11700106
226796654	226796677	2	+	28162770	MV411	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	-0.6086530378185113	[142]	[78]	-4	hSpCas9	negative selection	11869463
226796719	226796742	2	+	28162770	MV411	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	-1.8262721354002338	[260]	[61]	-8	hSpCas9	negative selection	11869464
226798514	226798537	2	-	28162770	MV411	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	1.7788190112990874	[63]	[184]	9	hSpCas9	negative selection	11869465
226798447	226798470	2	-	28162770	MV411	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	-0.19226200273033756	[117]	[86]	-1	hSpCas9	negative selection	11869466
226798284	226798307	2	-	28162770	MV411	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	-0.09073118511179779	[468]	[370]	0	hSpCas9	negative selection	11869467
226798132	226798155	2	-	28162770	MV411	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	0.21349021885943775	[85]	[83]	1	hSpCas9	negative selection	11869468
226797617	226797640	2	+	28162770	MV411	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	0.95684742242842	[73]	[120]	8	hSpCas9	negative selection	11869469
226797557	226797580	2	+	28162770	MV411	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	0.5615461412108382	[36]	[45]	5	hSpCas9	negative selection	11869470
226797099	226797122	2	+	28162770	MV411	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	-0.09359936705229155	[94]	[74]	0	hSpCas9	negative selection	11869471
226796996	226797019	2	+	28162770	MV411	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-4.39641863899195	[49]	[1]	-9	hSpCas9	negative selection	11869472
226796654	226796677	2	+	28162770	MONOMAC1	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	0.7598944310485604	[50]	[98]	7	hSpCas9	negative selection	12038829
226796719	226796742	2	+	28162770	MONOMAC1	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	-0.8491135436392468	[120]	[76]	-6	hSpCas9	negative selection	12038830
226798514	226798537	2	-	28162770	MONOMAC1	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	-1.2593211253138965	[70]	[33]	-7	hSpCas9	negative selection	12038831
226798447	226798470	2	-	28162770	MONOMAC1	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	-0.4662234798749427	[46]	[38]	-4	hSpCas9	negative selection	12038832
226798284	226798307	2	-	28162770	MONOMAC1	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.2924788681785666	[301]	[423]	3	hSpCas9	negative selection	12038833
226798132	226798155	2	-	28162770	MONOMAC1	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	0.5314172472511351	[101]	[168]	5	hSpCas9	negative selection	12038834
226797617	226797640	2	+	28162770	MONOMAC1	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	0.40499916702054406	[55]	[84]	4	hSpCas9	negative selection	12038835
226797557	226797580	2	+	28162770	MONOMAC1	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	0.2977278446900242	[21]	[30]	3	hSpCas9	negative selection	12038836
226797099	226797122	2	+	28162770	MONOMAC1	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	1.1686126252571265	[51]	[133]	8	hSpCas9	negative selection	12038837
226796996	226797019	2	+	28162770	MONOMAC1	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	0.5755526568373739	[23]	[40]	5	hSpCas9	negative selection	12038838
226796654	226796677	2	+	28162770	OCIAML2	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	-0.10430761099634545	[31]	[164]	-1	hSpCas9	negative selection	12208195
226796719	226796742	2	+	28162770	OCIAML2	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	-0.34409741931322935	[29]	[130]	-3	hSpCas9	negative selection	12208196
226798514	226798537	2	-	28162770	OCIAML2	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	0.7456880816846023	[16]	[157]	7	hSpCas9	negative selection	12208197
226798447	226798470	2	-	28162770	OCIAML2	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	0.17322636453256346	[15]	[99]	1	hSpCas9	negative selection	12208198
226798284	226798307	2	-	28162770	OCIAML2	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	-0.23860870270793644	[95]	[450]	-2	hSpCas9	negative selection	12208199
226798132	226798155	2	-	28162770	OCIAML2	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	-0.5071557012672753	[29]	[116]	-4	hSpCas9	negative selection	12208200
226797617	226797640	2	+	28162770	OCIAML2	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	-0.6882212603147881	[24]	[85]	-5	hSpCas9	negative selection	12208201
226797557	226797580	2	+	28162770	OCIAML2	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	-1.0986610478552035	[16]	[43]	-6	hSpCas9	negative selection	12208202
226797099	226797122	2	+	28162770	OCIAML2	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	0.3828215114048969	[21]	[158]	3	hSpCas9	negative selection	12208203
226796996	226797019	2	+	28162770	OCIAML2	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-3.6930222465786096	[6]	[2]	-9	hSpCas9	negative selection	12208204
226796654	226796677	2	+	28162770	OCIAML3	viability	ATAGCTGGTCCCGGAAGGGACGG	IRS1	ENSG00000169047	-0.009045139603006791	[30]	[92]	0	hSpCas9	negative selection	12377561
226796719	226796742	2	+	28162770	OCIAML3	viability	CAGGAGAGCAGCCACCGCTGGGG	IRS1	ENSG00000169047	0.0802221984940803	[46]	[149]	0	hSpCas9	negative selection	12377562
226798514	226798537	2	-	28162770	OCIAML3	viability	GCTGCTTCAACATCAACAAGCGG	IRS1	ENSG00000169047	-1.7501268422414449	[38]	[34]	-8	hSpCas9	negative selection	12377563
226798447	226798470	2	-	28162770	OCIAML3	viability	CGAGCACTTTGCCATCGCGGCGG	IRS1	ENSG00000169047	0.4059923596758367	[24]	[99]	4	hSpCas9	negative selection	12377564
226798284	226798307	2	-	28162770	OCIAML3	viability	GCTGGGGAGGACTTGAGCTACGG	IRS1	ENSG00000169047	0.9629404842273965	[129]	[764]	8	hSpCas9	negative selection	12377565
226798132	226798155	2	-	28162770	OCIAML3	viability	GAAGCTGAACTCGGAGGCAGCGG	IRS1	ENSG00000169047	-0.5565329349055004	[37]	[77]	-4	hSpCas9	negative selection	12377566
226797617	226797640	2	+	28162770	OCIAML3	viability	GGAGCGGCTGTGGTTGAGCGGGG	IRS1	ENSG00000169047	0.28513796480145126	[27]	[102]	2	hSpCas9	negative selection	12377567
226797557	226797580	2	+	28162770	OCIAML3	viability	GGACGACAGACTGACCGGGCTGG	IRS1	ENSG00000169047	-0.5065447990738239	[15]	[33]	-4	hSpCas9	negative selection	12377568
226797099	226797122	2	+	28162770	OCIAML3	viability	GAAGCCACTGAGGACTGGGACGG	IRS1	ENSG00000169047	-0.7064823695825757	[39]	[73]	-5	hSpCas9	negative selection	12377569
226796996	226797019	2	+	28162770	OCIAML3	viability	GGAGCGGGTGGGCACGAAGGCGG	IRS1	ENSG00000169047	-0.9159357352115254	[14]	[23]	-6	hSpCas9	negative selection	12377570