| 126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Jiyoye | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.17300579239307168 | 
                                                                                                                [286] | 
                                                                                                                [243] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                91542 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Jiyoye | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.9715276025517435 | 
                                                                                                                [93] | 
                                                                                                                [138] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                91543 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Jiyoye | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.9448321674486728 | 
                                                                                                                [61] | 
                                                                                                                [89] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                91544 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Jiyoye | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.48590941457761483 | 
                                                                                                                [25] | 
                                                                                                                [13] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                91545 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26472758 | 
                                                                                                                Jiyoye | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.335025595750038 | 
                                                                                                                [40] | 
                                                                                                                [77] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                91546 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Jiyoye | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.43578090834854666 | 
                                                                                                                [399] | 
                                                                                                                [222] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                91547 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Jiyoye | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.6186794866995848 | 
                                                                                                                [56] | 
                                                                                                                [131] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                91548 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Jiyoye | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1500421287323785 | 
                                                                                                                [102] | 
                                                                                                                [69] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                91549 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Jiyoye | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.04900081256645672 | 
                                                                                                                [165] | 
                                                                                                                [120] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                91550 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Jiyoye | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -2.123339335192906 | 
                                                                                                                [51] | 
                                                                                                                [8] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                91551 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.34126693948525066 | 
                                                                                                                [1233,1048] | 
                                                                                                                [389,450] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                282660 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.0635747010382024 | 
                                                                                                                [1052,998] | 
                                                                                                                [377,618] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                282661 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3485047536065266 | 
                                                                                                                [452,292] | 
                                                                                                                [332,117] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                282662 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.46826586548278626 | 
                                                                                                                [194,118] | 
                                                                                                                [74,31] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                282663 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26472758 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.16966393573998712 | 
                                                                                                                [453,271] | 
                                                                                                                [140,229] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                282664 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.20506176254381736 | 
                                                                                                                [990,766] | 
                                                                                                                [296,407] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                282665 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.30959937971020346 | 
                                                                                                                [814,668] | 
                                                                                                                [351,499] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                282666 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.063474603700028 | 
                                                                                                                [263,321] | 
                                                                                                                [124,164] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                282667 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.45232378436729825 | 
                                                                                                                [897,972] | 
                                                                                                                [668,551] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                282668 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8499812361048558 | 
                                                                                                                [64,105] | 
                                                                                                                [53,92] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                282669 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Raji | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.21454455951376294 | 
                                                                                                                [549] | 
                                                                                                                [109] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                473778 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Raji | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6130939360040377 | 
                                                                                                                [434] | 
                                                                                                                [65] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                473779 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Raji | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.4238572001688539 | 
                                                                                                                [105] | 
                                                                                                                [65] | 
                                                                                                                9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                473780 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Raji | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.7369655941662059 | 
                                                                                                                [78] | 
                                                                                                                [10] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                473781 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26472758 | 
                                                                                                                Raji | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.36210174792762084 | 
                                                                                                                [143] | 
                                                                                                                [25] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                473782 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Raji | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.027213186689616253 | 
                                                                                                                [443] | 
                                                                                                                [104] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                473783 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Raji | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.07303203058282248 | 
                                                                                                                [339] | 
                                                                                                                [82] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                473784 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Raji | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.06949422671048011 | 
                                                                                                                [103] | 
                                                                                                                [22] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                473785 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Raji | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.1287571861661665 | 
                                                                                                                [535] | 
                                                                                                                [135] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                473786 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                Raji | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.5390997757990736 | 
                                                                                                                [42] | 
                                                                                                                [28] | 
                                                                                                                9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                473787 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.23161996913979022 | 
                                                                                                                [1018] | 
                                                                                                                [1009] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                664896 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.13582616622940868 | 
                                                                                                                [661] | 
                                                                                                                [613] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                664897 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.4385472967841735 | 
                                                                                                                [242] | 
                                                                                                                [555] | 
                                                                                                                9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                664898 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.14789869511231357 | 
                                                                                                                [146] | 
                                                                                                                [111] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                664899 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26472758 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.45072669080513217 | 
                                                                                                                [203] | 
                                                                                                                [125] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                664900 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4109650506537892 | 
                                                                                                                [759] | 
                                                                                                                [852] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                664901 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2564381400734007 | 
                                                                                                                [657] | 
                                                                                                                [464] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                664902 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.30989356021452474 | 
                                                                                                                [162] | 
                                                                                                                [110] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                664903 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5633691227539139 | 
                                                                                                                [775] | 
                                                                                                                [967] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                664904 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26472758 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.082361969557474 | 
                                                                                                                [79] | 
                                                                                                                [142] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                664905 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                DLD1 | 
                                                                                                                viability | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.13403074011631505 | 
                                                                                                                [560] | 
                                                                                                                [208,171,194] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                826664 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                DLD1 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.04831887755150066 | 
                                                                                                                [1231] | 
                                                                                                                [388,450,292] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                826665 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                DLD1 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.17067337089070747 | 
                                                                                                                [615] | 
                                                                                                                [203,184,130] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                826666 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                DLD1 | 
                                                                                                                viability | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.08693693402982473 | 
                                                                                                                [435] | 
                                                                                                                [100,118,203] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                826667 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                DLD1 | 
                                                                                                                viability | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2685188464790462 | 
                                                                                                                [972] | 
                                                                                                                [431,372,303] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                826668 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                DLD1 | 
                                                                                                                viability | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1934080380550982 | 
                                                                                                                [386] | 
                                                                                                                [122,159,45] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                826669 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 5 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6003530354227506 | 
                                                                                                                [221] | 
                                                                                                                [176,183] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                908979 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 5 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.49782899627387023 | 
                                                                                                                [652] | 
                                                                                                                [287,207] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                908980 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 5 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.056585718417427655 | 
                                                                                                                [380] | 
                                                                                                                [241,182] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                908981 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 5 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2662187633804277 | 
                                                                                                                [337] | 
                                                                                                                [195,239] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                908982 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 5 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.01734724356389683 | 
                                                                                                                [501] | 
                                                                                                                [277,253] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                908983 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 5 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.16530729280939416 | 
                                                                                                                [142] | 
                                                                                                                [76,94] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                908984 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 13 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.2625395257381697 | 
                                                                                                                [221] | 
                                                                                                                [256,314] | 
                                                                                                                9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                991294 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 13 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2997953317852826 | 
                                                                                                                [652] | 
                                                                                                                [353,233] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                991295 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 13 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.27559741279545835 | 
                                                                                                                [380] | 
                                                                                                                [311,199] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                991296 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 13 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.024596744997225417 | 
                                                                                                                [337] | 
                                                                                                                [169,199] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                991297 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 13 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.04683450758832697 | 
                                                                                                                [501] | 
                                                                                                                [314,253] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                991298 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 13 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.33905345756105576 | 
                                                                                                                [142] | 
                                                                                                                [46,72] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                991299 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 21 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.6673109609407502 | 
                                                                                                                [221] | 
                                                                                                                [392,373] | 
                                                                                                                9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1073609 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 21 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.14123341733156547 | 
                                                                                                                [652] | 
                                                                                                                [340,303] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1073610 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 21 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.24498953579257599 | 
                                                                                                                [380] | 
                                                                                                                [249,240] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1073611 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 21 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6483880373063653 | 
                                                                                                                [337] | 
                                                                                                                [291,283] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1073612 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 21 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.4159804460283797 | 
                                                                                                                [501] | 
                                                                                                                [229,180] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1073613 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                GBM cells | 
                                                                                                                viability after 21 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.1305070521760896 | 
                                                                                                                [142] | 
                                                                                                                [83,85] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1073614 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 9 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8308155584192144 | 
                                                                                                                [1243] | 
                                                                                                                [197,245] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1155924 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 9 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.6597330720836498 | 
                                                                                                                [4018] | 
                                                                                                                [354,453] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1155925 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 9 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.9589989664375896 | 
                                                                                                                [1880] | 
                                                                                                                [267,347] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1155926 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 9 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.14364065101780252 | 
                                                                                                                [718] | 
                                                                                                                [204,304] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1155927 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 9 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.490032535098782 | 
                                                                                                                [2016] | 
                                                                                                                [250,190] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1155928 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 9 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6543866420597118 | 
                                                                                                                [345] | 
                                                                                                                [135,214] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1155929 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 12 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.0481209197586567 | 
                                                                                                                [1243] | 
                                                                                                                [199,120] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1238239 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 12 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.6799046692037487 | 
                                                                                                                [4018] | 
                                                                                                                [404,264] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1238240 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 12 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.6602754916302704 | 
                                                                                                                [1880] | 
                                                                                                                [87,235] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1238241 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 12 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.06529093798979224 | 
                                                                                                                [718] | 
                                                                                                                [171,233] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1238242 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 12 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.1067320233340388 | 
                                                                                                                [2016] | 
                                                                                                                [357,138] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1238243 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 12 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.9640592943742265 | 
                                                                                                                [345] | 
                                                                                                                [175,186] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1238244 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 15 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.7348784754778963 | 
                                                                                                                [1243] | 
                                                                                                                [326,99] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1320554 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 15 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.4746276866017491 | 
                                                                                                                [4018] | 
                                                                                                                [516,304] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1320555 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 15 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.9045014965034053 | 
                                                                                                                [1880] | 
                                                                                                                [134,148] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1320556 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 15 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6102665928841454 | 
                                                                                                                [718] | 
                                                                                                                [119,145] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1320557 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 15 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.7110537077586838 | 
                                                                                                                [2016] | 
                                                                                                                [317,377] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1320558 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 15 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4950536745691313 | 
                                                                                                                [345] | 
                                                                                                                [112,161] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1320559 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 18 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.8340426672998071 | 
                                                                                                                [1243] | 
                                                                                                                [127,57] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1402869 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 18 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.8516062825979844 | 
                                                                                                                [4018] | 
                                                                                                                [344,252] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1402870 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 18 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.332250478569605 | 
                                                                                                                [1880] | 
                                                                                                                [189,213] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1402871 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 18 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.82892494388587 | 
                                                                                                                [718] | 
                                                                                                                [115,101] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1402872 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 18 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.1900087011710625 | 
                                                                                                                [2016] | 
                                                                                                                [167,313] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1402873 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                RPE1 | 
                                                                                                                viability after 18 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4081331119025162 | 
                                                                                                                [345] | 
                                                                                                                [91,157] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1402874 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 8 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.24561162233408781 | 
                                                                                                                [516] | 
                                                                                                                [188,203,176] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1485184 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 8 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.4756437059456065 | 
                                                                                                                [2020] | 
                                                                                                                [630,234,162] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1485185 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 8 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.02411879913557924 | 
                                                                                                                [786] | 
                                                                                                                [346,283,408] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1485186 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 8 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.9117363659066798 | 
                                                                                                                [704] | 
                                                                                                                [174,200,118] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1485187 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 8 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.7751580394648073 | 
                                                                                                                [1157] | 
                                                                                                                [460,179,279] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1485188 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 8 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2513021661882046 | 
                                                                                                                [242] | 
                                                                                                                [136,101,139] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1485189 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 12 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6522875493295776 | 
                                                                                                                [516] | 
                                                                                                                [178,98,134] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1567499 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 12 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.4485114143137916 | 
                                                                                                                [2020] | 
                                                                                                                [504,162,270] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1567500 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 12 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3370722449973954 | 
                                                                                                                [786] | 
                                                                                                                [277,350,605] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1567501 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 12 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.0832035992594569 | 
                                                                                                                [704] | 
                                                                                                                [218,79,121] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1567502 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 12 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.0134389396449577 | 
                                                                                                                [1157] | 
                                                                                                                [231,227,251] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1567503 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 12 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5583400617703413 | 
                                                                                                                [242] | 
                                                                                                                [50,183,201] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1567504 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 15 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.26919588635356273 | 
                                                                                                                [516] | 
                                                                                                                [176,146,201] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1649814 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 15 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.2569350061075153 | 
                                                                                                                [2020] | 
                                                                                                                [335,423,266] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1649815 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 15 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.03567320307226751 | 
                                                                                                                [786] | 
                                                                                                                [317,217,408] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1649816 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 15 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.0988028788068585 | 
                                                                                                                [704] | 
                                                                                                                [115,118,169] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1649817 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 15 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6897563153573091 | 
                                                                                                                [1157] | 
                                                                                                                [296,247,334] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1649818 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 15 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.013676096792821668 | 
                                                                                                                [242] | 
                                                                                                                [99,34,163] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1649819 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 18 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.27573839555764257 | 
                                                                                                                [516] | 
                                                                                                                [112,126,201] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1732129 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 18 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.2775732266704967 | 
                                                                                                                [2020] | 
                                                                                                                [219,345,266] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1732130 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 18 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.060988386516192095 | 
                                                                                                                [786] | 
                                                                                                                [199,183,408] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1732131 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 18 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.0914068451545778 | 
                                                                                                                [704] | 
                                                                                                                [81,94,169] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1732132 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 18 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.7147336038973807 | 
                                                                                                                [1157] | 
                                                                                                                [196,195,334] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1732133 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HeLa | 
                                                                                                                viability after 18 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.012711998284799297 | 
                                                                                                                [242] | 
                                                                                                                [68,30,163] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1732134 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 6 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6112233260272171 | 
                                                                                                                [975] | 
                                                                                                                [225,238] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1814444 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 6 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.23290432581694653 | 
                                                                                                                [1590] | 
                                                                                                                [304,161] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1814445 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 6 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2610216565731508 | 
                                                                                                                [1216] | 
                                                                                                                [100,299] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1814446 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 6 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.21062140489391348 | 
                                                                                                                [593] | 
                                                                                                                [32,106] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1814447 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 6 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5323127657132435 | 
                                                                                                                [926] | 
                                                                                                                [164,235] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1814448 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 6 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.9731281863788832 | 
                                                                                                                [272] | 
                                                                                                                [42,106] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1814449 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 8 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5965241742913985 | 
                                                                                                                [240] | 
                                                                                                                [175,228,196] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1896759 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 8 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.07570165020788622 | 
                                                                                                                [851] | 
                                                                                                                [353,469,509] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1896760 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 8 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.10830751038814135 | 
                                                                                                                [563] | 
                                                                                                                [224,368,269] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1896761 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 8 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.21025953051947593 | 
                                                                                                                [336] | 
                                                                                                                [230,216,196] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1896762 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 8 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.11930163434639907 | 
                                                                                                                [727] | 
                                                                                                                [323,238,541] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1896763 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 8 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4544063710671757 | 
                                                                                                                [191] | 
                                                                                                                [166,181,86] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1896764 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 9 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.3618849562180055 | 
                                                                                                                [975] | 
                                                                                                                [68,126] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1979074 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 9 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.17434308375895147 | 
                                                                                                                [1590] | 
                                                                                                                [247,477] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1979075 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 9 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8841013594431095 | 
                                                                                                                [1216] | 
                                                                                                                [141,202] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1979076 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 9 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8318445034058596 | 
                                                                                                                [593] | 
                                                                                                                [192,6] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1979077 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 9 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8060669155375092 | 
                                                                                                                [926] | 
                                                                                                                [224,596] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1979078 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 9 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.17785046972887453 | 
                                                                                                                [272] | 
                                                                                                                [126,14] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                1979079 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 12 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8133975579060273 | 
                                                                                                                [240] | 
                                                                                                                [275,262,124] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2061389 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 12 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2599120225540279 | 
                                                                                                                [851] | 
                                                                                                                [387,559,673] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2061390 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 12 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.004279648771564393 | 
                                                                                                                [563] | 
                                                                                                                [264,310,318] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2061391 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 12 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.160793647419817 | 
                                                                                                                [336] | 
                                                                                                                [117,206,154] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2061392 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 12 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.005114889487368046 | 
                                                                                                                [727] | 
                                                                                                                [433,159,547] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2061393 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 12 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.7829932579774379 | 
                                                                                                                [191] | 
                                                                                                                [100,204,221] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2061394 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 15 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.9892958654237429 | 
                                                                                                                [240] | 
                                                                                                                [228,337,251] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2143704 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 15 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.016449183839619685 | 
                                                                                                                [851] | 
                                                                                                                [335,601,526] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2143705 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 15 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.36895737254212935 | 
                                                                                                                [563] | 
                                                                                                                [213,286,246] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2143706 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 15 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.35351437066330754 | 
                                                                                                                [336] | 
                                                                                                                [226,151,358] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2143707 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 15 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.040453624560659485 | 
                                                                                                                [727] | 
                                                                                                                [488,368,438] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2143708 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 15 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8217757954607275 | 
                                                                                                                [191] | 
                                                                                                                [225,209,152] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2143709 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 18 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.7390812034989462 | 
                                                                                                                [240] | 
                                                                                                                [129,292,151] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2226019 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 18 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.018259275900275318 | 
                                                                                                                [851] | 
                                                                                                                [250,531,429] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2226020 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 18 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.47800901972296206 | 
                                                                                                                [563] | 
                                                                                                                [133,197,257] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2226021 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 18 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.08977375329485317 | 
                                                                                                                [336] | 
                                                                                                                [64,165,230] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2226022 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 18 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5205871412136627 | 
                                                                                                                [727] | 
                                                                                                                [430,403,694] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2226023 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26627737 | 
                                                                                                                HCT116 | 
                                                                                                                viability after 18 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.20475735184309218 | 
                                                                                                                [191] | 
                                                                                                                [126,140,47] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2226024 | 
                                                                            
                                                                                                        126810176 | 
                                                                                                                126810199 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                24336569 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                TTCTGGTCTCGTTAATCTCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.2580733938518447 | 
                                                                                                                [113] | 
                                                                                                                [576] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2274851 | 
                                                                            
                                                                                                        126810193 | 
                                                                                                                126810216 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                24336569 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                GCGCGTTTCATGCTTCCTTCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8013083210184543 | 
                                                                                                                [188] | 
                                                                                                                [696] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2274852 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                24336569 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5431247698274134 | 
                                                                                                                [1173] | 
                                                                                                                [1704] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2274853 | 
                                                                            
                                                                                                        126810213 | 
                                                                                                                126810236 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                24336569 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                CGCTTGGTAGAGGTGGATTCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.12102025624981966 | 
                                                                                                                [720] | 
                                                                                                                [1402] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2274854 | 
                                                                            
                                                                                                        126810242 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                24336569 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                AATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.542677542094381 | 
                                                                                                                [1004] | 
                                                                                                                [3097] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2274855 | 
                                                                            
                                                                                                        126810271 | 
                                                                                                                126810294 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                24336569 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                TTGCTCTCTCATCTCATGAAGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.728153872937277 | 
                                                                                                                [90] | 
                                                                                                                [318] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2274856 | 
                                                                            
                                                                                                        126810289 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                24336569 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                AGCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.49334125901441195 | 
                                                                                                                [911] | 
                                                                                                                [1370] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2274857 | 
                                                                            
                                                                                                        126810299 | 
                                                                                                                126810322 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                24336569 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                TGCCCAAGTGAGGCTGTATAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.020492964516784895 | 
                                                                                                                [634] | 
                                                                                                                [1362] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2274858 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                24336569 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.358945188358259 | 
                                                                                                                [464] | 
                                                                                                                [1261] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2274859 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                24336569 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.19520626667808472 | 
                                                                                                                [830] | 
                                                                                                                [1535] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2274860 | 
                                                                            
                                                                                                        126810176 | 
                                                                                                                126810199 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                24336569 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                TTCTGGTCTCGTTAATCTCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.274318949528382 | 
                                                                                                                [230] | 
                                                                                                                [761] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2342028 | 
                                                                            
                                                                                                        126810193 | 
                                                                                                                126810216 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                24336569 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                GCGCGTTTCATGCTTCCTTCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8363851542545467 | 
                                                                                                                [217] | 
                                                                                                                [332] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2342029 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                24336569 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8252311317737888 | 
                                                                                                                [477] | 
                                                                                                                [2309] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2342030 | 
                                                                            
                                                                                                        126810213 | 
                                                                                                                126810236 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                24336569 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                CGCTTGGTAGAGGTGGATTCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4568218470339383 | 
                                                                                                                [463] | 
                                                                                                                [1736] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2342031 | 
                                                                            
                                                                                                        126810242 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                24336569 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                AATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2581724127061693 | 
                                                                                                                [854] | 
                                                                                                                [2788] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2342032 | 
                                                                            
                                                                                                        126810271 | 
                                                                                                                126810294 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                24336569 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                TTGCTCTCTCATCTCATGAAGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5435660055649761 | 
                                                                                                                [285] | 
                                                                                                                [1136] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2342033 | 
                                                                            
                                                                                                        126810289 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                24336569 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                AGCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.012284483793095435 | 
                                                                                                                [662] | 
                                                                                                                [1792] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2342034 | 
                                                                            
                                                                                                        126810299 | 
                                                                                                                126810322 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                24336569 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                TGCCCAAGTGAGGCTGTATAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.4827686250111826 | 
                                                                                                                [497] | 
                                                                                                                [971] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2342035 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                24336569 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.22565313857220565 | 
                                                                                                                [441] | 
                                                                                                                [1030] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2342036 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                24336569 | 
                                                                                                                KBM7 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.27688373044692927 | 
                                                                                                                [831] | 
                                                                                                                [1872] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                2342037 | 
                                                                            
                                                                                                        126776988 | 
                                                                                                                126777011 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (puromycin) | 
                                                                                                                ACCATGGGCCAATGGGGAGCAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.9605944521964278 | 
                                                                                                                [249,9] | 
                                                                                                                [13,13] | 
                                                                                                                -5 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2409865 | 
                                                                            
                                                                                                        126777036 | 
                                                                                                                126777059 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (puromycin) | 
                                                                                                                GCCGCACTCCCCAACATGGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1809218196654676 | 
                                                                                                                [116,169] | 
                                                                                                                [15,39] | 
                                                                                                                0 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2409866 | 
                                                                            
                                                                                                        126776967 | 
                                                                                                                126776990 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (puromycin) | 
                                                                                                                GGCAGCGCGCTTCGGCGGTTCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.1046536479785292 | 
                                                                                                                [205,105] | 
                                                                                                                [6,24] | 
                                                                                                                -6 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2409867 | 
                                                                            
                                                                                                        126780145 | 
                                                                                                                126780168 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (puromycin) | 
                                                                                                                TGGTCCACTGCACTCCAGCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5818803995338353 | 
                                                                                                                [10,18] | 
                                                                                                                [6,1] | 
                                                                                                                2 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2412546 | 
                                                                            
                                                                                                        126808885 | 
                                                                                                                126808908 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (puromycin) | 
                                                                                                                TTTTTTTTTGAGACGGAGTCCAG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.0033727294007129816 | 
                                                                                                                [93,134] | 
                                                                                                                [41,5] | 
                                                                                                                0 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2412624 | 
                                                                            
                                                                                                        126803327 | 
                                                                                                                126803350 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (puromycin) | 
                                                                                                                CACTTGAACCCAGGAGGCAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.4184778160092897 | 
                                                                                                                [54,284] | 
                                                                                                                [10,16] | 
                                                                                                                -7 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2414571 | 
                                                                            
                                                                                                        126789715 | 
                                                                                                                126789738 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (puromycin) | 
                                                                                                                CACACCACTGCACTCCAGCCAAG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6897978744123147 | 
                                                                                                                [436,52] | 
                                                                                                                [50,12] | 
                                                                                                                -4 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2457731 | 
                                                                            
                                                                                                        126789018 | 
                                                                                                                126789041 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (puromycin) | 
                                                                                                                GCCTGTAGTCCCAGCTACTCCAG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4848717924049799 | 
                                                                                                                [259,492] | 
                                                                                                                [140,88] | 
                                                                                                                2 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2468663 | 
                                                                            
                                                                                                        126781059 | 
                                                                                                                126781082 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (puromycin) | 
                                                                                                                CAGGTGGATCACCTGAAGTCAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.080501538256204 | 
                                                                                                                [504,81] | 
                                                                                                                [37,20] | 
                                                                                                                -6 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2472809 | 
                                                                            
                                                                                                        126776988 | 
                                                                                                                126777011 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (zeocin) | 
                                                                                                                ACCATGGGCCAATGGGGAGCAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.905678826440118 | 
                                                                                                                [190,169] | 
                                                                                                                [33,28] | 
                                                                                                                -8 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2505120 | 
                                                                            
                                                                                                        126777036 | 
                                                                                                                126777059 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (zeocin) | 
                                                                                                                GCCGCACTCCCCAACATGGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8623780145055541 | 
                                                                                                                [78,154] | 
                                                                                                                [43,92] | 
                                                                                                                6 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2505121 | 
                                                                            
                                                                                                        126776967 | 
                                                                                                                126776990 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (zeocin) | 
                                                                                                                GGCAGCGCGCTTCGGCGGTTCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                2.397309928636535 | 
                                                                                                                [80,155] | 
                                                                                                                [28,366] | 
                                                                                                                9 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2505122 | 
                                                                            
                                                                                                        126780145 | 
                                                                                                                126780168 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (zeocin) | 
                                                                                                                TGGTCCACTGCACTCCAGCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1513722508810107 | 
                                                                                                                [22,67] | 
                                                                                                                [15,9] | 
                                                                                                                -1 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2507801 | 
                                                                            
                                                                                                        126808885 | 
                                                                                                                126808908 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (zeocin) | 
                                                                                                                TTTTTTTTTGAGACGGAGTCCAG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5948176551250917 | 
                                                                                                                [72,353] | 
                                                                                                                [48,41] | 
                                                                                                                -6 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2507879 | 
                                                                            
                                                                                                        126803327 | 
                                                                                                                126803350 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (zeocin) | 
                                                                                                                CACTTGAACCCAGGAGGCAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5761613238144463 | 
                                                                                                                [143,285] | 
                                                                                                                [83,121] | 
                                                                                                                4 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2509826 | 
                                                                            
                                                                                                        126789715 | 
                                                                                                                126789738 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (zeocin) | 
                                                                                                                CACACCACTGCACTCCAGCCAAG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2274396231328648 | 
                                                                                                                [285,212] | 
                                                                                                                [141,51] | 
                                                                                                                1 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2552986 | 
                                                                            
                                                                                                        126789018 | 
                                                                                                                126789041 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (zeocin) | 
                                                                                                                GCCTGTAGTCCCAGCTACTCCAG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2857588864060996 | 
                                                                                                                [349,998] | 
                                                                                                                [76,442] | 
                                                                                                                2 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2563918 | 
                                                                            
                                                                                                        126781059 | 
                                                                                                                126781082 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                25494202 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX-4720 (zeocin) | 
                                                                                                                CAGGTGGATCACCTGAAGTCAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.09148827261213754 | 
                                                                                                                [58,380] | 
                                                                                                                [33,114] | 
                                                                                                                0 | 
                                                                                                                dCas9-VP64 | 
                                                                                                                positive selection | 
                                                                                                                2568064 | 
                                                                            
                                                                                                        126777530 | 
                                                                                                                126777553 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27453484 | 
                                                                                                                HT29 | 
                                                                                                                resistance to T3SS1-dependent cytotoxicity | 
                                                                                                                GCGCGGCTGCCCATCCGCGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.378024389669149 | 
                                                                                                                [2,2] | 
                                                                                                                [3,0] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                2999688 | 
                                                                            
                                                                                                        126777692 | 
                                                                                                                126777715 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27453484 | 
                                                                                                                HT29 | 
                                                                                                                resistance to T3SS1-dependent cytotoxicity | 
                                                                                                                GCTGCAGGTGACGGAGCGCGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.25922500807177074 | 
                                                                                                                [1,1] | 
                                                                                                                [1,0] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                2999689 | 
                                                                            
                                                                                                        126777635 | 
                                                                                                                126777658 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27453484 | 
                                                                                                                HT29 | 
                                                                                                                resistance to T3SS1-dependent cytotoxicity | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.14617618943363775 | 
                                                                                                                [2,2] | 
                                                                                                                [1,2] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                2999690 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27453484 | 
                                                                                                                HT29 | 
                                                                                                                resistance to T3SS1-dependent cytotoxicity | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1816652875580474 | 
                                                                                                                [3,3] | 
                                                                                                                [4,0] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                2999691 | 
                                                                            
                                                                                                        126777530 | 
                                                                                                                126777553 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27453484 | 
                                                                                                                HT29 | 
                                                                                                                resistance to T3SS2-dependent cytotoxicity | 
                                                                                                                GCGCGGCTGCCCATCCGCGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.056477731308560236 | 
                                                                                                                [2,2] | 
                                                                                                                [4,0] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3067546 | 
                                                                            
                                                                                                        126777692 | 
                                                                                                                126777715 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27453484 | 
                                                                                                                HT29 | 
                                                                                                                resistance to T3SS2-dependent cytotoxicity | 
                                                                                                                GCTGCAGGTGACGGAGCGCGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.056919507911881606 | 
                                                                                                                [1,1] | 
                                                                                                                [0,0] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3067547 | 
                                                                            
                                                                                                        126777635 | 
                                                                                                                126777658 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27453484 | 
                                                                                                                HT29 | 
                                                                                                                resistance to T3SS2-dependent cytotoxicity | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.020187963772785 | 
                                                                                                                [2,2] | 
                                                                                                                [0,0] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3067548 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27453484 | 
                                                                                                                HT29 | 
                                                                                                                resistance to T3SS2-dependent cytotoxicity | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.0925751794557704 | 
                                                                                                                [3,3] | 
                                                                                                                [2,2] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3067549 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                 | 
                                                                                                                - | 
                                                                                                                24336571 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX after 7 days | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.20633716920511214 | 
                                                                                                                [4,5] | 
                                                                                                                [6,5] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3124881 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                 | 
                                                                                                                + | 
                                                                                                                24336571 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX after 7 days | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.30827054293750156 | 
                                                                                                                [17,18] | 
                                                                                                                [19,25] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3124882 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                 | 
                                                                                                                - | 
                                                                                                                24336571 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX after 14 days | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6194939221353389 | 
                                                                                                                [3,4] | 
                                                                                                                [2,2] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3182674 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                 | 
                                                                                                                + | 
                                                                                                                24336571 | 
                                                                                                                A375 | 
                                                                                                                resistance to PLX after 14 days | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5877843579084162 | 
                                                                                                                [18,18] | 
                                                                                                                [17,7] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3182675 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                 | 
                                                                                                                - | 
                                                                                                                24336571 | 
                                                                                                                A375 | 
                                                                                                                viability after 7 days | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8075682500062551 | 
                                                                                                                [9] | 
                                                                                                                [4,5] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3240467 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                 | 
                                                                                                                + | 
                                                                                                                24336571 | 
                                                                                                                A375 | 
                                                                                                                viability after 7 days | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2407990336296234 | 
                                                                                                                [16] | 
                                                                                                                [17,18] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3240468 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                 | 
                                                                                                                - | 
                                                                                                                24336571 | 
                                                                                                                A375 | 
                                                                                                                viability after 14 days | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.0877520029582843 | 
                                                                                                                [9] | 
                                                                                                                [3,4] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3298260 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                 | 
                                                                                                                + | 
                                                                                                                24336571 | 
                                                                                                                A375 | 
                                                                                                                viability after 14 days | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.28914933958642186 | 
                                                                                                                [16] | 
                                                                                                                [18,18] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3298261 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27383988 | 
                                                                                                                293T | 
                                                                                                                resistance to West Nile virus (flavivirus) | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.0047686339243442 | 
                                                                                                                [306,306] | 
                                                                                                                [0,0] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3377325 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27383988 | 
                                                                                                                293T | 
                                                                                                                resistance to West Nile virus (flavivirus) | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.21027933863716222 | 
                                                                                                                [176,176] | 
                                                                                                                [0,0] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3377326 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27383988 | 
                                                                                                                293T | 
                                                                                                                resistance to West Nile virus (flavivirus) | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.4759664979211755 | 
                                                                                                                [54,54] | 
                                                                                                                [0,0] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3377327 | 
                                                                            
                                                                                                        126777530 | 
                                                                                                                126777553 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                HT29 | 
                                                                                                                viability (Avana library 4 designs) | 
                                                                                                                GCGCGGCTGCCCATCCGCGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.73961216933956 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3437249 | 
                                                                            
                                                                                                        126777691 | 
                                                                                                                126777714 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                HT29 | 
                                                                                                                viability (Avana library 4 designs) | 
                                                                                                                GCTGCAGGTGACGGAGCGCGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.84646158037861 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3437250 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                HT29 | 
                                                                                                                viability (Avana library 4 designs) | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                2.32726754880073 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3437251 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                HT29 | 
                                                                                                                viability (Avana library 4 designs) | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                2.02206753121986 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3437252 | 
                                                                            
                                                                                                        126777691 | 
                                                                                                                126777714 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability (Avana lentiCRISPRv2) | 
                                                                                                                GCTGCAGGTGACGGAGCGCGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                5.85873637633753 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3525871 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability (Avana lentiCRISPRv2) | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                4.21017877300064 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3525872 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability (Avana lentiCRISPRv2) | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.163357635285214 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3525873 | 
                                                                            
                                                                                                        126777530 | 
                                                                                                                126777553 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability (Avana lentiCRISPRv2) | 
                                                                                                                GCGCGGCTGCCCATCCGCGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                3.62293392342433 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3525874 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability (Avana lentiCRISPRv2) | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.44703599162675 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3525875 | 
                                                                            
                                                                                                        126811808 | 
                                                                                                                126811831 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability (Avana lentiCRISPRv2) | 
                                                                                                                TTCTACTGTCAACAGTGCCAGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -3.05578880595402 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3525876 | 
                                                                            
                                                                                                        126777691 | 
                                                                                                                126777714 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability (Avana lentiGuide) | 
                                                                                                                GCTGCAGGTGACGGAGCGCGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.430867791258522 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3634530 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability (Avana lentiGuide) | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.815725033141992 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3634531 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability (Avana lentiGuide) | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                13.3407540861313 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3634532 | 
                                                                            
                                                                                                        126777530 | 
                                                                                                                126777553 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability (Avana lentiGuide) | 
                                                                                                                GCGCGGCTGCCCATCCGCGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -3.82953157474441 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3634533 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability (Avana lentiGuide) | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.210785087035139 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3634534 | 
                                                                            
                                                                                                        126811808 | 
                                                                                                                126811831 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability (Avana lentiGuide) | 
                                                                                                                TTCTACTGTCAACAGTGCCAGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                5.79213083947416 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3634535 | 
                                                                            
                                                                                                        126777691 | 
                                                                                                                126777714 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (Avana lentiCRISPRv2) | 
                                                                                                                GCTGCAGGTGACGGAGCGCGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.10378122283771918 | 
                                                                                                                [3] | 
                                                                                                                [4,2] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3743189 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (Avana lentiCRISPRv2) | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.23541541196764362 | 
                                                                                                                [4] | 
                                                                                                                [5,5] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3743190 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (Avana lentiCRISPRv2) | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5351832973535842 | 
                                                                                                                [3] | 
                                                                                                                [2,1] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3743191 | 
                                                                            
                                                                                                        126777530 | 
                                                                                                                126777553 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (Avana lentiCRISPRv2) | 
                                                                                                                GCGCGGCTGCCCATCCGCGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.27182911389534065 | 
                                                                                                                [4] | 
                                                                                                                [5,5] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3743192 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (Avana lentiCRISPRv2) | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1541707319088467 | 
                                                                                                                [5] | 
                                                                                                                [4,4] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3743193 | 
                                                                            
                                                                                                        126811808 | 
                                                                                                                126811831 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (Avana lentiCRISPRv2) | 
                                                                                                                TTCTACTGTCAACAGTGCCAGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.04296973434228275 | 
                                                                                                                [5] | 
                                                                                                                [4,5] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3743194 | 
                                                                            
                                                                                                        126777691 | 
                                                                                                                126777714 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (Avana lentiGuide) | 
                                                                                                                GCTGCAGGTGACGGAGCGCGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.24452953723113524 | 
                                                                                                                [3] | 
                                                                                                                [4,2] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3851796 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (Avana lentiGuide) | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.09712680774411923 | 
                                                                                                                [5] | 
                                                                                                                [5,2] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3851797 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (Avana lentiGuide) | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.42705644355476613 | 
                                                                                                                [4] | 
                                                                                                                [3,2] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3851798 | 
                                                                            
                                                                                                        126777530 | 
                                                                                                                126777553 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (Avana lentiGuide) | 
                                                                                                                GCGCGGCTGCCCATCCGCGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.18646945800896497 | 
                                                                                                                [4] | 
                                                                                                                [4,4] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3851799 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (Avana lentiGuide) | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.12495919207561774 | 
                                                                                                                [5] | 
                                                                                                                [3,3] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3851800 | 
                                                                            
                                                                                                        126811808 | 
                                                                                                                126811831 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (Avana lentiGuide) | 
                                                                                                                TTCTACTGTCAACAGTGCCAGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.07405466885663739 | 
                                                                                                                [4] | 
                                                                                                                [4,2] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                3851801 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.480814177312823 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3957446 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.52062798749349 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3957447 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.537422486199447 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3957448 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.555055231118379 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3957449 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.73704454068089 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3957450 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.00295418380704 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                3957451 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                HT29 | 
                                                                                                                viability (GeCKOv2 library) | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.908294931382216 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4065412 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                HT29 | 
                                                                                                                viability (GeCKOv2 library) | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.13077049073349 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4065413 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                HT29 | 
                                                                                                                viability (GeCKOv2 library) | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.277349827779461 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4065414 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                HT29 | 
                                                                                                                viability (GeCKOv2 library) | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.95052888495575 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4065415 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                HT29 | 
                                                                                                                viability (GeCKOv2 library) | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.374146967525215 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4065416 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                HT29 | 
                                                                                                                viability (GeCKOv2 library) | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.31314035301217 | 
                                                                                                                [] | 
                                                                                                                [] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4065417 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.051011066496766344 | 
                                                                                                                [2] | 
                                                                                                                [1,1] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                4148966 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.10929356512964837 | 
                                                                                                                [4] | 
                                                                                                                [2,3] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                4148967 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (GeCKOv1 lentiGuide) | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3466769762048326 | 
                                                                                                                [3] | 
                                                                                                                [0,2,0,0] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                4212988 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (GeCKOv1 lentiGuide) | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.12347060386136735 | 
                                                                                                                [2] | 
                                                                                                                [1,1,1,0] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                4212989 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (GeCKOv2 lentiGuide) | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1198643624010387 | 
                                                                                                                [3] | 
                                                                                                                [3,1] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                4280360 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (GeCKOv2 lentiGuide) | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.22818970862105628 | 
                                                                                                                [3] | 
                                                                                                                [3,1] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                4280361 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (GeCKOv2 lentiGuide) | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1303973001877548 | 
                                                                                                                [2] | 
                                                                                                                [2,0] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                4280362 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (GeCKOv2 lentiGuide) | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4551564552223626 | 
                                                                                                                [4] | 
                                                                                                                [4,4] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                4344620 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (GeCKOv2 lentiGuide) | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.10779716546270492 | 
                                                                                                                [2] | 
                                                                                                                [2,1] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                4344621 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                26780180 | 
                                                                                                                A375 | 
                                                                                                                resistance to vemurafenib (GeCKOv2 lentiGuide) | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.44717229237084444 | 
                                                                                                                [1] | 
                                                                                                                [1,0] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                positive selection | 
                                                                                                                4344622 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.41208171796219184 | 
                                                                                                                [587,517] | 
                                                                                                                [510,656] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4414746 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6707468255463487 | 
                                                                                                                [581,469] | 
                                                                                                                [481,871] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4414747 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5439127905238389 | 
                                                                                                                [593,450] | 
                                                                                                                [261,298] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4414748 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.012064866555936 | 
                                                                                                                [89,96] | 
                                                                                                                [42,27] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4414749 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5087142521485207 | 
                                                                                                                [695,590] | 
                                                                                                                [654,789] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4414750 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.22489189893836192 | 
                                                                                                                [587,517] | 
                                                                                                                [422,651] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4498209 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.37308895294753125 | 
                                                                                                                [581,469] | 
                                                                                                                [472,646] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4498210 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.25841770737481895 | 
                                                                                                                [593,450] | 
                                                                                                                [331,374] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4498211 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.44282677868846676 | 
                                                                                                                [89,96] | 
                                                                                                                [55,55] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4498212 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.13322432770269454 | 
                                                                                                                [695,590] | 
                                                                                                                [447,505] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4498213 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6023651627003989 | 
                                                                                                                [587,517] | 
                                                                                                                [518,603] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4581672 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5654235057237575 | 
                                                                                                                [581,469] | 
                                                                                                                [577,409] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4581673 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.9799467536321311 | 
                                                                                                                [593,450] | 
                                                                                                                [760,544] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4581674 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8276217170857283 | 
                                                                                                                [89,96] | 
                                                                                                                [18,58] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4581675 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.40175449841486754 | 
                                                                                                                [695,590] | 
                                                                                                                [668,393] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4581676 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3308304203597594 | 
                                                                                                                [587,517] | 
                                                                                                                [307,411] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4665135 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.30381426439132536 | 
                                                                                                                [581,469] | 
                                                                                                                [510,544] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4665136 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6200894785732929 | 
                                                                                                                [593,450] | 
                                                                                                                [208,345] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4665137 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.645949948343811 | 
                                                                                                                [89,96] | 
                                                                                                                [9,39] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4665138 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HL60 | 
                                                                                                                viability | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2632107597754113 | 
                                                                                                                [695,590] | 
                                                                                                                [419,453] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4665139 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT1080 | 
                                                                                                                viability | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.16825833983081534 | 
                                                                                                                [517,403] | 
                                                                                                                [66,268] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4748598 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT1080 | 
                                                                                                                viability | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.9120444004093592 | 
                                                                                                                [469,366] | 
                                                                                                                [191,446] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4748599 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT1080 | 
                                                                                                                viability | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3245240077982914 | 
                                                                                                                [450,351] | 
                                                                                                                [79,331] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4748600 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT1080 | 
                                                                                                                viability | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.9189186427535607 | 
                                                                                                                [96,75] | 
                                                                                                                [0,17] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4748601 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT1080 | 
                                                                                                                viability | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6828944646167905 | 
                                                                                                                [590,460] | 
                                                                                                                [375,292] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4748602 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 7 days | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.04494753636915533 | 
                                                                                                                [517,403] | 
                                                                                                                [446,793,466] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4832061 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 7 days | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2944040111267636 | 
                                                                                                                [469,366] | 
                                                                                                                [768,714,514] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4832062 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 7 days | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.06613396783456435 | 
                                                                                                                [450,351] | 
                                                                                                                [409,477,575] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4832063 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 7 days | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.646037171262047 | 
                                                                                                                [96,75] | 
                                                                                                                [55,33,19] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4832064 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 7 days | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5503398267554496 | 
                                                                                                                [590,460] | 
                                                                                                                [943,965,1050] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4832065 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 25 days | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.10942596222671946 | 
                                                                                                                [517,403] | 
                                                                                                                [252,617,621] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4915524 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 25 days | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6514022210989563 | 
                                                                                                                [469,366] | 
                                                                                                                [747,768,733] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4915525 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 25 days | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.16855652205993177 | 
                                                                                                                [450,351] | 
                                                                                                                [250,531,455] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4915526 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 25 days | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.703238205524367 | 
                                                                                                                [96,75] | 
                                                                                                                [11,42,37] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4915527 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 25 days | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8771551363300658 | 
                                                                                                                [590,460] | 
                                                                                                                [760,942,1688] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4915528 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 22 days | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.31702485699250665 | 
                                                                                                                [517,403] | 
                                                                                                                [407,538,335] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4998987 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 22 days | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4153860711221451 | 
                                                                                                                [469,366] | 
                                                                                                                [686,664,581] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4998988 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 22 days | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.18785442653383436 | 
                                                                                                                [450,351] | 
                                                                                                                [511,706,365] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4998989 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 22 days | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.73637501368438 | 
                                                                                                                [96,75] | 
                                                                                                                [6,19,63] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4998990 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 22 days | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6071151432986237 | 
                                                                                                                [590,460] | 
                                                                                                                [771,848,1163] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                4998991 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 19 days | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.10696122869091673 | 
                                                                                                                [517,403] | 
                                                                                                                [544,463,465] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5082450 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 19 days | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6115071718851277 | 
                                                                                                                [469,366] | 
                                                                                                                [509,1163,504] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5082451 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 19 days | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.18591757961022606 | 
                                                                                                                [450,351] | 
                                                                                                                [626,330,615] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5082452 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 19 days | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -3.4434275606004965 | 
                                                                                                                [96,75] | 
                                                                                                                [1,0,22] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5082453 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 19 days | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.1591113233182888 | 
                                                                                                                [590,460] | 
                                                                                                                [1444,1200,1391] | 
                                                                                                                9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5082454 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 16 days | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.46886988457800444 | 
                                                                                                                [517,403] | 
                                                                                                                [383,446,285] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5165913 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 16 days | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5234545081551621 | 
                                                                                                                [469,366] | 
                                                                                                                [707,722,589] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5165914 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 16 days | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.37646343823501394 | 
                                                                                                                [450,351] | 
                                                                                                                [509,559,672] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5165915 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 16 days | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -2.760049765530563 | 
                                                                                                                [96,75] | 
                                                                                                                [1,2,36] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5165916 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 16 days | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8921842905203154 | 
                                                                                                                [590,460] | 
                                                                                                                [971,825,1473] | 
                                                                                                                9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5165917 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 13 days | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.4094501071332434 | 
                                                                                                                [517,403] | 
                                                                                                                [439,368,398] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5249376 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 13 days | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5795814158498375 | 
                                                                                                                [469,366] | 
                                                                                                                [760,800,620] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5249377 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 13 days | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.15071464952132457 | 
                                                                                                                [450,351] | 
                                                                                                                [396,429,430] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5249378 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 13 days | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -2.2370008310991194 | 
                                                                                                                [96,75] | 
                                                                                                                [1,24,35] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5249379 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 13 days | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5723727772507157 | 
                                                                                                                [590,460] | 
                                                                                                                [885,793,1033] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5249380 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 10 days | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5630018155539981 | 
                                                                                                                [517,403] | 
                                                                                                                [499,345,322] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5332839 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 10 days | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4764152592039623 | 
                                                                                                                [469,366] | 
                                                                                                                [534,1015,639] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5332840 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 10 days | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.18883198702411033 | 
                                                                                                                [450,351] | 
                                                                                                                [826,414,469] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5332841 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 10 days | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.9730099089434168 | 
                                                                                                                [96,75] | 
                                                                                                                [19,39,22] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5332842 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                HT29 | 
                                                                                                                viability after 10 days | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.678548235220245 | 
                                                                                                                [590,460] | 
                                                                                                                [1235,905,1007] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5332843 | 
                                                                            
                                                                                                        126777776 | 
                                                                                                                126777798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                CGACGCGCGCTCGACGACACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8604740285003194 | 
                                                                                                                [587,517] | 
                                                                                                                [130,205] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5416302 | 
                                                                            
                                                                                                        126804917 | 
                                                                                                                126804939 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                GGATCAGATTGCCCAGGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.04681894963825903 | 
                                                                                                                [581,469] | 
                                                                                                                [275,293] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5416303 | 
                                                                            
                                                                                                        126810204 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                CATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.39113824627020366 | 
                                                                                                                [593,450] | 
                                                                                                                [222,222] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5416304 | 
                                                                            
                                                                                                        126810243 | 
                                                                                                                126810265 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                ATTGAGTATGAGTACAAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5836581622468793 | 
                                                                                                                [89,96] | 
                                                                                                                [22,45] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5416305 | 
                                                                            
                                                                                                        126810290 | 
                                                                                                                126810312 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27760321 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                GCAACATGATGCCCAAGTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2997303371309957 | 
                                                                                                                [695,590] | 
                                                                                                                [278,586] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5416306 | 
                                                                            
                                                                                                        126777133 | 
                                                                                                                126777156 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27661255 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                GCCGCTCCGTGCAGCCTGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2751202810617308 | 
                                                                                                                [322,328] | 
                                                                                                                [253,181] | 
                                                                                                                -6 | 
                                                                                                                dCas9-KRAB | 
                                                                                                                negative selection | 
                                                                                                                5490557 | 
                                                                            
                                                                                                        126777446 | 
                                                                                                                126777469 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27661255 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                GGACCGTGATAAGGAGGGGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.010376477400974693 | 
                                                                                                                [366,524] | 
                                                                                                                [382,333] | 
                                                                                                                0 | 
                                                                                                                dCas9-KRAB | 
                                                                                                                negative selection | 
                                                                                                                5490558 | 
                                                                            
                                                                                                        126777569 | 
                                                                                                                126777592 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27661255 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                GACAGGCGCGTGGGGCTCAGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.106203078323475 | 
                                                                                                                [679,920] | 
                                                                                                                [764,615] | 
                                                                                                                3 | 
                                                                                                                dCas9-KRAB | 
                                                                                                                negative selection | 
                                                                                                                5490559 | 
                                                                            
                                                                                                        126777577 | 
                                                                                                                126777600 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27661255 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                GGAGCCGCGACAGGCGCGTGGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.07508560396693142 | 
                                                                                                                [1280,1357] | 
                                                                                                                [1140,1081] | 
                                                                                                                2 | 
                                                                                                                dCas9-KRAB | 
                                                                                                                negative selection | 
                                                                                                                5490560 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                BXPC3 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3246874430766054 | 
                                                                                                                [548] | 
                                                                                                                [654,607,727,917] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5552820 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                BXPC3 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.508830269165752 | 
                                                                                                                [854] | 
                                                                                                                [543,586,579,833] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5552821 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                BXPC3 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.17469715302948685 | 
                                                                                                                [277] | 
                                                                                                                [163,277,295,305] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5552822 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                BXPC3 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.11127658589475997 | 
                                                                                                                [1041] | 
                                                                                                                [1175,1076,1093,1381] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5617080 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                BXPC3 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3589110959119787 | 
                                                                                                                [324] | 
                                                                                                                [375,433,451,491] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5617081 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                BXPC3 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3569917958236859 | 
                                                                                                                [176] | 
                                                                                                                [125,137,128,191] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5617082 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                A673 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.020713340165259386 | 
                                                                                                                [548] | 
                                                                                                                [717,581,620,688] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5674071 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                A673 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6444047229045342 | 
                                                                                                                [854] | 
                                                                                                                [757,558,563,765] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5674072 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                A673 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.45198048646632993 | 
                                                                                                                [277] | 
                                                                                                                [233,295,191,251] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5674073 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                A673 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.12263013367455788 | 
                                                                                                                [1041] | 
                                                                                                                [1277,1081,1168,1077] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5738331 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                A673 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2271568285454576 | 
                                                                                                                [324] | 
                                                                                                                [332,337,353,305] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5738332 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                A673 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.409939139435735 | 
                                                                                                                [176] | 
                                                                                                                [122,133,165,215] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5738333 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                A375 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.1788204487404787 | 
                                                                                                                [548] | 
                                                                                                                [761,509,837,756] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5795322 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                A375 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.4507881784021722 | 
                                                                                                                [854] | 
                                                                                                                [911,742,677,604] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5795323 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                A375 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.006029548135781715 | 
                                                                                                                [277] | 
                                                                                                                [350,310,293,342] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5795324 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                A375 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4325394997259342 | 
                                                                                                                [1041] | 
                                                                                                                [1736,1703,1646,1501] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5859582 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                A375 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.16915263993235063 | 
                                                                                                                [324] | 
                                                                                                                [234,514,442,512] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5859583 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                A375 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.08254133005644926 | 
                                                                                                                [176] | 
                                                                                                                [194,178,273,136] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5859584 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                COLO741 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.13455666745262723 | 
                                                                                                                [548] | 
                                                                                                                [967,659,701] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5916573 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                COLO741 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.4417323922706462 | 
                                                                                                                [854] | 
                                                                                                                [1017,692,723] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5916574 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                COLO741 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.10428265940548831 | 
                                                                                                                [277] | 
                                                                                                                [309,405,276] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5916575 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                COLO741 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.205058773736003 | 
                                                                                                                [1041] | 
                                                                                                                [1817,1408,1406] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5980833 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                COLO741 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.029706599653049115 | 
                                                                                                                [324] | 
                                                                                                                [454,431,388] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5980834 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                COLO741 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.039653853500033254 | 
                                                                                                                [176] | 
                                                                                                                [213,223,220] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                5980835 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                CAL120 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.34754803352237124 | 
                                                                                                                [548] | 
                                                                                                                [637,1197,738] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6037824 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                CAL120 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.7121567274611962 | 
                                                                                                                [854] | 
                                                                                                                [789,629,550] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6037825 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                CAL120 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.37523278959430495 | 
                                                                                                                [277] | 
                                                                                                                [476,302,567] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6037826 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                CAL120 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.10027149988397399 | 
                                                                                                                [1041] | 
                                                                                                                [1705,1293,1219] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6102084 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                CAL120 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6096210747450017 | 
                                                                                                                [324] | 
                                                                                                                [829,599,455] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6102085 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                CAL120 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2122847721446568 | 
                                                                                                                [176] | 
                                                                                                                [210,92,267] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6102086 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                CADOES1 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.10128538801407494 | 
                                                                                                                [548] | 
                                                                                                                [562,629,452,544] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6159075 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                CADOES1 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3005590968354438 | 
                                                                                                                [854] | 
                                                                                                                [695,663,615,604] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6159076 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                CADOES1 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.18265368043038666 | 
                                                                                                                [277] | 
                                                                                                                [239,290,186,191] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6159077 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                CADOES1 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.25568857329403416 | 
                                                                                                                [1041] | 
                                                                                                                [1303,1023,1027,1275] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6223335 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                CADOES1 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.14270630331058243 | 
                                                                                                                [324] | 
                                                                                                                [310,315,368,338] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6223336 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                CADOES1 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.26579167650242064 | 
                                                                                                                [176] | 
                                                                                                                [136,75,236,95] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6223337 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                EWS502 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.23980290196516468 | 
                                                                                                                [548] | 
                                                                                                                [738,543,719,744] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6280326 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                EWS502 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.626629549708616 | 
                                                                                                                [854] | 
                                                                                                                [546,529,775,493] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6280327 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                EWS502 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.10727456646900779 | 
                                                                                                                [277] | 
                                                                                                                [171,377,400,333] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6280328 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                EWS502 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.281589707107075 | 
                                                                                                                [1041] | 
                                                                                                                [1051,1368,1492,1493] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6344586 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                EWS502 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.036896612531036876 | 
                                                                                                                [324] | 
                                                                                                                [190,431,405,402] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6344587 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                EWS502 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.44642275315043944 | 
                                                                                                                [176] | 
                                                                                                                [117,122,162,149] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6344588 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                EW8 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.03997894318041334 | 
                                                                                                                [548] | 
                                                                                                                [634,440,314,480] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6401577 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                EW8 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3942269543143914 | 
                                                                                                                [854] | 
                                                                                                                [539,588,468,520] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6401578 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                EW8 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6267133204075126 | 
                                                                                                                [277] | 
                                                                                                                [131,127,136,185] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6401579 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                EW8 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.06971921717258733 | 
                                                                                                                [1041] | 
                                                                                                                [905,1092,743,826] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6465837 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                EW8 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5157789769127394 | 
                                                                                                                [324] | 
                                                                                                                [184,190,162,200] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6465838 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                EW8 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8402417740647012 | 
                                                                                                                [176] | 
                                                                                                                [31,79,78,123] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6465839 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                CORL105 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.07255871501211902 | 
                                                                                                                [548] | 
                                                                                                                [801,642,609,642] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6522828 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                CORL105 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.42792295110440015 | 
                                                                                                                [854] | 
                                                                                                                [600,777,813,787] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6522829 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                CORL105 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.10543769151014959 | 
                                                                                                                [277] | 
                                                                                                                [338,453,372,235] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6522830 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                CORL105 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.32333542412335103 | 
                                                                                                                [1041] | 
                                                                                                                [1444,1471,1923,1324] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6587088 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                CORL105 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2567716864465186 | 
                                                                                                                [324] | 
                                                                                                                [484,419,448,464] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6587089 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                CORL105 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.19249046842788275 | 
                                                                                                                [176] | 
                                                                                                                [174,167,204,180] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6587090 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                HS294T | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.24554856390077123 | 
                                                                                                                [548] | 
                                                                                                                [257,286,211,245] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6644079 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                HS294T | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3770421862701779 | 
                                                                                                                [854] | 
                                                                                                                [219,253,225,333] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6644080 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                HS294T | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3210146549444399 | 
                                                                                                                [277] | 
                                                                                                                [82,71,106,81] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6644081 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                HS294T | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.46566978028475936 | 
                                                                                                                [1041] | 
                                                                                                                [737,488,420,560] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6708339 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                HS294T | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.018600911852928892 | 
                                                                                                                [324] | 
                                                                                                                [83,148,127,155] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6708340 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                HS294T | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.35968861776523986 | 
                                                                                                                [176] | 
                                                                                                                [46,83,41,36] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6708341 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                HCC44 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.21646689190465968 | 
                                                                                                                [548] | 
                                                                                                                [441,720,940,785] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6765330 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                HCC44 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3483397738781826 | 
                                                                                                                [854] | 
                                                                                                                [679,887,869,592] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6765331 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                HCC44 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.39573410052058766 | 
                                                                                                                [277] | 
                                                                                                                [215,291,330,124] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6765332 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                HCC44 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3003412627511437 | 
                                                                                                                [1041] | 
                                                                                                                [1150,1263,1767,1656] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6829590 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                HCC44 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.046887177291450755 | 
                                                                                                                [324] | 
                                                                                                                [495,338,428,279] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6829591 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                HCC44 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5027854948972572 | 
                                                                                                                [176] | 
                                                                                                                [53,217,254,40] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6829592 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                G402 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.18744026100438937 | 
                                                                                                                [548] | 
                                                                                                                [1045,680,350,994] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6886581 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                G402 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.18518617252458458 | 
                                                                                                                [854] | 
                                                                                                                [849,654,926,1195] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6886582 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                G402 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2466952989294231 | 
                                                                                                                [277] | 
                                                                                                                [142,562,146,284] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6886583 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                G402 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4946728314828328 | 
                                                                                                                [1041] | 
                                                                                                                [2344,1674,1460,1752] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6950841 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                G402 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5156580191002242 | 
                                                                                                                [324] | 
                                                                                                                [407,751,496,594] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6950842 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                G402 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.45591368374997643 | 
                                                                                                                [176] | 
                                                                                                                [194,94,246,96] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                6950843 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                L33 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.24764392436998012 | 
                                                                                                                [548] | 
                                                                                                                [602,277,429,642] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7007832 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                L33 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.18304094691596762 | 
                                                                                                                [854] | 
                                                                                                                [877,282,482,672] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7007833 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                L33 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.09573259717445148 | 
                                                                                                                [277] | 
                                                                                                                [230,132,172,210] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7007834 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                L33 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2150026959837008 | 
                                                                                                                [1041] | 
                                                                                                                [1231,443,728,1359] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7072092 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                L33 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.15521758222605786 | 
                                                                                                                [324] | 
                                                                                                                [398,126,218,388] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7072093 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                L33 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.858186316806606 | 
                                                                                                                [176] | 
                                                                                                                [66,43,77,92] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7072094 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.1572978744790119 | 
                                                                                                                [548] | 
                                                                                                                [489,853,635,238] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7129083 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.39912198923939163 | 
                                                                                                                [854] | 
                                                                                                                [459,415,789,610] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7129084 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.06094517091898044 | 
                                                                                                                [277] | 
                                                                                                                [294,340,117,204] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7129085 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.335671804178177 | 
                                                                                                                [1041] | 
                                                                                                                [1008,1247,1068,1310] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7193343 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.21915465671333134 | 
                                                                                                                [324] | 
                                                                                                                [282,387,295,55] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7193344 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                K562 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8231272292145262 | 
                                                                                                                [176] | 
                                                                                                                [100,47,128,76] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7193345 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                HT29 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.13356745968829803 | 
                                                                                                                [548] | 
                                                                                                                [941,770,671,576] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7250334 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                HT29 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.4043862968546294 | 
                                                                                                                [854] | 
                                                                                                                [784,1035,721,632] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7250335 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                HT29 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.20617457297295028 | 
                                                                                                                [277] | 
                                                                                                                [453,261,403,425] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7250336 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                HT29 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3140419744278533 | 
                                                                                                                [1041] | 
                                                                                                                [1497,1743,1721,1358] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7314594 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                HT29 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.15685357796449112 | 
                                                                                                                [324] | 
                                                                                                                [499,639,322,330] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7314595 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                HT29 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5255197958011752 | 
                                                                                                                [176] | 
                                                                                                                [159,145,129,159] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7314596 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                MHHES1 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.162119221769997 | 
                                                                                                                [548] | 
                                                                                                                [678,688,894,526] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7371585 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                MHHES1 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.20544623679026164 | 
                                                                                                                [854] | 
                                                                                                                [973,905,948,577] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7371586 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                MHHES1 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.06282966470308693 | 
                                                                                                                [277] | 
                                                                                                                [345,500,138,331] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7371587 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                MHHES1 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.05722542532904207 | 
                                                                                                                [1041] | 
                                                                                                                [1757,1166,1311,782] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7435845 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                MHHES1 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2624232016009925 | 
                                                                                                                [324] | 
                                                                                                                [590,298,334,507] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7435846 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                MHHES1 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.18769880273863948 | 
                                                                                                                [176] | 
                                                                                                                [142,292,205,83] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7435847 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                MEWO | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.286553904340287 | 
                                                                                                                [548] | 
                                                                                                                [696,617,577] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7492836 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                MEWO | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.34842406074148347 | 
                                                                                                                [854] | 
                                                                                                                [585,731,557] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7492837 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                MEWO | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.06748132631025949 | 
                                                                                                                [277] | 
                                                                                                                [305,195,253] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7492838 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                MEWO | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.10520667928924698 | 
                                                                                                                [1041] | 
                                                                                                                [1089,1169,892] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7557096 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                MEWO | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.16223046175630246 | 
                                                                                                                [324] | 
                                                                                                                [289,324,395] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7557097 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                MEWO | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.44248765396781486 | 
                                                                                                                [176] | 
                                                                                                                [82,123,150] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7557098 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                LNCAPCLONEFGC | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.20838148496281306 | 
                                                                                                                [548] | 
                                                                                                                [614,470,762,482] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7614087 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                LNCAPCLONEFGC | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8973169428827057 | 
                                                                                                                [854] | 
                                                                                                                [356,300,639,406] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7614088 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                LNCAPCLONEFGC | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.614709859740455 | 
                                                                                                                [277] | 
                                                                                                                [172,82,211,201] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7614089 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                LNCAPCLONEFGC | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2921953069509091 | 
                                                                                                                [1041] | 
                                                                                                                [1089,833,1613,1174] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7678347 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                LNCAPCLONEFGC | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.1276978708251838 | 
                                                                                                                [324] | 
                                                                                                                [321,281,442,259] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7678348 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                LNCAPCLONEFGC | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.794504676307582 | 
                                                                                                                [176] | 
                                                                                                                [91,75,140,68] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7678349 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PANC0327 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.29045402644572077 | 
                                                                                                                [548] | 
                                                                                                                [525,550,757,550] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7735338 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                PANC0327 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2523050543387626 | 
                                                                                                                [854] | 
                                                                                                                [618,491,833,622] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7735339 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PANC0327 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.07980373836319432 | 
                                                                                                                [277] | 
                                                                                                                [264,124,188,371] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7735340 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PANC0327 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.11638614938884806 | 
                                                                                                                [1041] | 
                                                                                                                [1064,855,1325,790] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7799598 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                PANC0327 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5491884047484068 | 
                                                                                                                [324] | 
                                                                                                                [471,146,382,726] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7799599 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PANC0327 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.39728476704090476 | 
                                                                                                                [176] | 
                                                                                                                [137,247,85,344] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7799600 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                NCIH2009 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.43689731668770143 | 
                                                                                                                [548] | 
                                                                                                                [1343,853,978] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7856589 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                NCIH2009 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.15338948844337186 | 
                                                                                                                [854] | 
                                                                                                                [1140,833,1262] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7856590 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                NCIH2009 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2007951225160528 | 
                                                                                                                [277] | 
                                                                                                                [366,337,313] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7856591 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                NCIH2009 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.17149555708677267 | 
                                                                                                                [1041] | 
                                                                                                                [1826,1697,1426] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7920849 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                NCIH2009 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.517209845012387 | 
                                                                                                                [324] | 
                                                                                                                [627,989,319] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7920850 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                NCIH2009 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.7142504157125573 | 
                                                                                                                [176] | 
                                                                                                                [123,186,134] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7920851 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                NCIH1373 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.10760749829962662 | 
                                                                                                                [548] | 
                                                                                                                [663,441,825,194] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7977840 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                NCIH1373 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1052906608249945 | 
                                                                                                                [854] | 
                                                                                                                [1137,591,747,307] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7977841 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                NCIH1373 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.9914275250726243 | 
                                                                                                                [277] | 
                                                                                                                [216,109,160,39] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                7977842 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                NCIH1373 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5613018033156083 | 
                                                                                                                [1041] | 
                                                                                                                [1377,1422,2076,523] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8042100 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                NCIH1373 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.36153882193377407 | 
                                                                                                                [324] | 
                                                                                                                [565,462,340,136] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8042101 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                NCIH1373 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8259123673613138 | 
                                                                                                                [176] | 
                                                                                                                [202,81,69,28] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8042102 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PATU8902 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.04611047596677453 | 
                                                                                                                [548] | 
                                                                                                                [652,1115,526,944] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8099091 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                PATU8902 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.75536626814181 | 
                                                                                                                [854] | 
                                                                                                                [426,785,796,796] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8099092 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PATU8902 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6681474738032109 | 
                                                                                                                [277] | 
                                                                                                                [445,257,159,111] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8099093 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PATU8902 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.25562077796473237 | 
                                                                                                                [1041] | 
                                                                                                                [1523,1910,1706,1790] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8163351 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                PATU8902 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2736071181675094 | 
                                                                                                                [324] | 
                                                                                                                [392,349,185,646] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8163352 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PATU8902 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5171464305040834 | 
                                                                                                                [176] | 
                                                                                                                [125,40,231,286] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8163353 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PANC1 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.16321724539805238 | 
                                                                                                                [548] | 
                                                                                                                [522,777,396,465] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8220342 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                PANC1 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.67074422678352 | 
                                                                                                                [854] | 
                                                                                                                [503,600,423,353] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8220343 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PANC1 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2755022360258226 | 
                                                                                                                [277] | 
                                                                                                                [116,339,303,76] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8220344 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PANC1 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2708892525898048 | 
                                                                                                                [1041] | 
                                                                                                                [1032,1513,961,909] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8284602 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                PANC1 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.17982054977126166 | 
                                                                                                                [324] | 
                                                                                                                [271,538,302,209] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8284603 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PANC1 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.0798280983545976 | 
                                                                                                                [176] | 
                                                                                                                [65,75,129,23] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8284604 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PANC0813 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.13717295291126486 | 
                                                                                                                [548] | 
                                                                                                                [638,691,659,830] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8341593 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                PANC0813 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3391357623484379 | 
                                                                                                                [854] | 
                                                                                                                [830,850,729,766] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8341594 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PANC0813 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3295985461758175 | 
                                                                                                                [277] | 
                                                                                                                [336,245,256,208] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8341595 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PANC0813 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.1436715701075595 | 
                                                                                                                [1041] | 
                                                                                                                [1472,1408,1428,1119] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8405853 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                PANC0813 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3036802719851992 | 
                                                                                                                [324] | 
                                                                                                                [459,445,485,489] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8405854 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PANC0813 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.44209189637942115 | 
                                                                                                                [176] | 
                                                                                                                [169,179,88,172] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8405855 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                RDES | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2948870140095194 | 
                                                                                                                [548] | 
                                                                                                                [595,697,891,969] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8462844 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                RDES | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6000866022871247 | 
                                                                                                                [854] | 
                                                                                                                [536,581,617,906] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8462845 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                RDES | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6123182193602145 | 
                                                                                                                [277] | 
                                                                                                                [873,287,350,322] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8462846 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                RDES | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.30765848713467037 | 
                                                                                                                [1041] | 
                                                                                                                [1376,1158,1583,1884] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8527104 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                RDES | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3113919605264881 | 
                                                                                                                [324] | 
                                                                                                                [428,430,529,462] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8527105 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                RDES | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.25335502790380704 | 
                                                                                                                [176] | 
                                                                                                                [107,224,167,187] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8527106 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PC3 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.42545727206908807 | 
                                                                                                                [548] | 
                                                                                                                [399,573,1719,723] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8584095 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                PC3 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.4128500686887985 | 
                                                                                                                [854] | 
                                                                                                                [458,625,890,693] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8584096 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PC3 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.49713043883816144 | 
                                                                                                                [277] | 
                                                                                                                [184,101,329,203] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8584097 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PC3 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.03601052161115925 | 
                                                                                                                [1041] | 
                                                                                                                [532,1069,1670,1162] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8648355 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                PC3 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.20278234694341357 | 
                                                                                                                [324] | 
                                                                                                                [203,311,376,269] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8648356 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PC3 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.43598106807625125 | 
                                                                                                                [176] | 
                                                                                                                [97,168,78,152] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8648357 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PATU8988T | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.04185132455453791 | 
                                                                                                                [548] | 
                                                                                                                [394,612,369,709] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8705346 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                PATU8988T | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6134652602490329 | 
                                                                                                                [854] | 
                                                                                                                [436,566,767,373] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8705347 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PATU8988T | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2773741909328582 | 
                                                                                                                [277] | 
                                                                                                                [173,339,254,119] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8705348 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PATU8988T | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.01979705222046646 | 
                                                                                                                [1041] | 
                                                                                                                [611,1120,1343,1009] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8769606 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                PATU8988T | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6233945002515631 | 
                                                                                                                [324] | 
                                                                                                                [149,166,267,227] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8769607 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                PATU8988T | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.2637072047586957 | 
                                                                                                                [176] | 
                                                                                                                [41,77,105,57] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8769608 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                T47D | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.12367243898905955 | 
                                                                                                                [548] | 
                                                                                                                [746,591,706,751] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8826597 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                T47D | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.42964301651103143 | 
                                                                                                                [854] | 
                                                                                                                [757,636,757,815] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8826598 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                T47D | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.17200631317696036 | 
                                                                                                                [277] | 
                                                                                                                [294,334,260,253] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8826599 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                T47D | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.23193843916346668 | 
                                                                                                                [1041] | 
                                                                                                                [1529,1375,1306,1497] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8890857 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                T47D | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.15243026761753664 | 
                                                                                                                [324] | 
                                                                                                                [394,389,453,446] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8890858 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                T47D | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6581161259215362 | 
                                                                                                                [176] | 
                                                                                                                [129,116,96,181] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8890859 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                SU8686 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.07351746658063368 | 
                                                                                                                [548] | 
                                                                                                                [460,415,657,828] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8947848 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                SU8686 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.24990821727910462 | 
                                                                                                                [854] | 
                                                                                                                [602,599,742,969] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8947849 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                SU8686 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.4072192776994661 | 
                                                                                                                [277] | 
                                                                                                                [185,111,339,210] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                8947850 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                SU8686 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.20382102440148664 | 
                                                                                                                [1041] | 
                                                                                                                [1124,1151,1253,1241] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9012108 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                SU8686 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.0095756894435024 | 
                                                                                                                [324] | 
                                                                                                                [318,180,316,509] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9012109 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                SU8686 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6591291970908653 | 
                                                                                                                [176] | 
                                                                                                                [107,88,143,105] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9012110 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                SKES1 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.19343264447245218 | 
                                                                                                                [548] | 
                                                                                                                [663,616,566,651] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9069099 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                SKES1 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5151945558008442 | 
                                                                                                                [854] | 
                                                                                                                [648,618,572,554] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9069100 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                SKES1 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.19622605069136478 | 
                                                                                                                [277] | 
                                                                                                                [330,212,176,252] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9069101 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                SKES1 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.097033611227624 | 
                                                                                                                [1041] | 
                                                                                                                [1097,1124,1079,1129] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9133359 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                SKES1 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.14278368128370955 | 
                                                                                                                [324] | 
                                                                                                                [229,271,320,331] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9133360 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                SKES1 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6374258151291687 | 
                                                                                                                [176] | 
                                                                                                                [180,85,64,125] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9133361 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                TOV112D | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.22442744468653392 | 
                                                                                                                [548] | 
                                                                                                                [587,745,596,657] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9190350 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                TOV112D | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3309712846470506 | 
                                                                                                                [854] | 
                                                                                                                [566,1104,470,673] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9190351 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                TOV112D | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.48908424461869293 | 
                                                                                                                [277] | 
                                                                                                                [158,245,140,253] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9190352 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                TOV112D | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.13616128842925934 | 
                                                                                                                [1041] | 
                                                                                                                [1346,1396,985,939] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9254610 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                TOV112D | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.019867540604349143 | 
                                                                                                                [324] | 
                                                                                                                [237,705,199,229] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9254611 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                TOV112D | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.1736890478759447 | 
                                                                                                                [176] | 
                                                                                                                [49,78,107,74] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9254612 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                TC71 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.24519529612029067 | 
                                                                                                                [548] | 
                                                                                                                [804,708,504,779] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9311601 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                TC71 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2255296147117899 | 
                                                                                                                [854] | 
                                                                                                                [776,925,770,653] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9311602 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                TC71 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.15759926475475772 | 
                                                                                                                [277] | 
                                                                                                                [241,362,288,445] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9311603 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                TC71 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.17372408854528998 | 
                                                                                                                [1041] | 
                                                                                                                [1155,1258,1257,1375] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9375861 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                TC71 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.13201861173875307 | 
                                                                                                                [324] | 
                                                                                                                [373,396,368,387] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9375862 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                TC71 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6250876945383939 | 
                                                                                                                [176] | 
                                                                                                                [143,105,135,103] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9375863 | 
                                                                            
                                                                                                        126810203 | 
                                                                                                                126810226 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                TC32 | 
                                                                                                                viability | 
                                                                                                                GCATGAAACGCGCTTGGTAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.00447797577137668 | 
                                                                                                                [548] | 
                                                                                                                [421,414,694,578] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9432852 | 
                                                                            
                                                                                                        126804809 | 
                                                                                                                126804832 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                TC32 | 
                                                                                                                viability | 
                                                                                                                CATATTCTCGAAGCTTGATCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2830502678392992 | 
                                                                                                                [854] | 
                                                                                                                [593,539,908,654] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9432853 | 
                                                                            
                                                                                                        126805642 | 
                                                                                                                126805665 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                TC32 | 
                                                                                                                viability | 
                                                                                                                TCGTTGTCAGAGCCTTACTGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.356634712801041 | 
                                                                                                                [277] | 
                                                                                                                [211,136,238,248] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9432854 | 
                                                                            
                                                                                                        126804767 | 
                                                                                                                126804790 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                TC32 | 
                                                                                                                viability | 
                                                                                                                CTGTTCCAGCTATGCTAAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.14418848980002874 | 
                                                                                                                [1041] | 
                                                                                                                [955,925,1249,1242] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9497112 | 
                                                                            
                                                                                                        126805654 | 
                                                                                                                126805677 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27260156 | 
                                                                                                                TC32 | 
                                                                                                                viability | 
                                                                                                                GAAACTCCAAGTCCTCAGTAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3698788772438531 | 
                                                                                                                [324] | 
                                                                                                                [627,175,398,405] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9497113 | 
                                                                            
                                                                                                        126810178 | 
                                                                                                                126810201 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27260156 | 
                                                                                                                TC32 | 
                                                                                                                viability | 
                                                                                                                AGGAGATTAACGAGACCAGAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.17478898573535573 | 
                                                                                                                [176] | 
                                                                                                                [114,182,144,124] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9497114 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 27 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.9862148040405667 | 
                                                                                                                [262] | 
                                                                                                                [166,362,NaN] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9589751 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 27 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.05311133645956234 | 
                                                                                                                [755] | 
                                                                                                                [401,420,NaN] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9589752 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 27 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.0401877838952262 | 
                                                                                                                [337] | 
                                                                                                                [198,150,NaN] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9589753 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 27 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.34646777937096 | 
                                                                                                                [360] | 
                                                                                                                [67,216,NaN] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9589754 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 27 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5226639433977993 | 
                                                                                                                [586] | 
                                                                                                                [270,167,NaN] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9589755 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 27 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4271046502234317 | 
                                                                                                                [204] | 
                                                                                                                [235,68,NaN] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9589756 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 15 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.35441553585583285 | 
                                                                                                                [262] | 
                                                                                                                [332,378,NaN] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9672200 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 15 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.06582783629062705 | 
                                                                                                                [755] | 
                                                                                                                [789,887,NaN] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9672201 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 15 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3802605389113803 | 
                                                                                                                [337] | 
                                                                                                                [568,412,NaN] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9672202 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 15 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5394866448727057 | 
                                                                                                                [360] | 
                                                                                                                [454,149,NaN] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9672203 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 15 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.4041098682837735 | 
                                                                                                                [586] | 
                                                                                                                [797,276,NaN] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9672204 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 15 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2580403118324362 | 
                                                                                                                [204] | 
                                                                                                                [297,241,NaN] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9672205 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                ASPC1 | 
                                                                                                                viability after 36 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6198024962355828 | 
                                                                                                                [841] | 
                                                                                                                [881,365,212] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9754649 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                ASPC1 | 
                                                                                                                viability after 36 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.1489492848652385 | 
                                                                                                                [1584] | 
                                                                                                                [506,961,404] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9754650 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                ASPC1 | 
                                                                                                                viability after 36 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.15912152281972858 | 
                                                                                                                [937] | 
                                                                                                                [197,292,536] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9754651 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                ASPC1 | 
                                                                                                                viability after 36 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.19612598596733513 | 
                                                                                                                [717] | 
                                                                                                                [202,158,274] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9754652 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                ASPC1 | 
                                                                                                                viability after 36 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.08331890089060157 | 
                                                                                                                [1217] | 
                                                                                                                [508,401,320] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9754653 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                ASPC1 | 
                                                                                                                viability after 36 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.848716380539708 | 
                                                                                                                [335] | 
                                                                                                                [969,318,115] | 
                                                                                                                9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9754654 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                PATU8988S | 
                                                                                                                viability after 35 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1453824616539414 | 
                                                                                                                [515] | 
                                                                                                                [142,232,NaN] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9837098 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                PATU8988S | 
                                                                                                                viability after 35 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.26568596384463894 | 
                                                                                                                [1581] | 
                                                                                                                [741,316,NaN] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9837099 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                PATU8988S | 
                                                                                                                viability after 35 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8214990585077742 | 
                                                                                                                [1018] | 
                                                                                                                [628,821,NaN] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9837100 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                PATU8988S | 
                                                                                                                viability after 35 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.25955152891301214 | 
                                                                                                                [587] | 
                                                                                                                [120,274,NaN] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9837101 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                PATU8988S | 
                                                                                                                viability after 35 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.37824405528968985 | 
                                                                                                                [1040] | 
                                                                                                                [737,350,NaN] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9837102 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                PATU8988S | 
                                                                                                                viability after 35 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.332086065965699 | 
                                                                                                                [332] | 
                                                                                                                [123,88,NaN] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9837103 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                PATU8988S | 
                                                                                                                viability after 31 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.17984723173519104 | 
                                                                                                                [515] | 
                                                                                                                [174,306,NaN] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9919547 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                PATU8988S | 
                                                                                                                viability after 31 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.11178560546798244 | 
                                                                                                                [1581] | 
                                                                                                                [680,459,NaN] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9919548 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                PATU8988S | 
                                                                                                                viability after 31 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.27749880588592957 | 
                                                                                                                [1018] | 
                                                                                                                [378,636,NaN] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9919549 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                PATU8988S | 
                                                                                                                viability after 31 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.24391462405947165 | 
                                                                                                                [587] | 
                                                                                                                [153,253,NaN] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9919550 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                PATU8988S | 
                                                                                                                viability after 31 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5977710988092936 | 
                                                                                                                [1040] | 
                                                                                                                [775,439,NaN] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9919551 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                PATU8988S | 
                                                                                                                viability after 31 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.06021364100241455 | 
                                                                                                                [332] | 
                                                                                                                [96,165,NaN] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                9919552 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 35 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.3751584527909049 | 
                                                                                                                [262] | 
                                                                                                                [255,445,NaN] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10001996 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 35 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.307048679658007 | 
                                                                                                                [755] | 
                                                                                                                [401,553,NaN] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10001997 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 35 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.21970052846909457 | 
                                                                                                                [337] | 
                                                                                                                [145,147,NaN] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10001998 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 35 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.42588440297373936 | 
                                                                                                                [360] | 
                                                                                                                [96,179,NaN] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10001999 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 35 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6121029394517523 | 
                                                                                                                [586] | 
                                                                                                                [208,177,NaN] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10002000 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 35 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6700706875837136 | 
                                                                                                                [204] | 
                                                                                                                [190,135,NaN] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10002001 | 
                                                                            
                                                                                                        126777631 | 
                                                                                                                126777654 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 31 days | 
                                                                                                                TGTCGATGTACACCGCCAGCCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.0154177928828276 | 
                                                                                                                [262] | 
                                                                                                                [194,410,NaN] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10084445 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 31 days | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.17190934684440062 | 
                                                                                                                [755] | 
                                                                                                                [387,575,NaN] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10084446 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 31 days | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.11974245700669023 | 
                                                                                                                [337] | 
                                                                                                                [241,166,NaN] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10084447 | 
                                                                            
                                                                                                        126819121 | 
                                                                                                                126819144 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 31 days | 
                                                                                                                TCTTAGAAGGCGAAGAAGAGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.29011622671061227 | 
                                                                                                                [360] | 
                                                                                                                [102,233,NaN] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10084448 | 
                                                                            
                                                                                                        126820936 | 
                                                                                                                126820959 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 31 days | 
                                                                                                                TGCTCGGGATACTGTCACACGGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6875861460210375 | 
                                                                                                                [586] | 
                                                                                                                [238,166,NaN] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10084449 | 
                                                                            
                                                                                                        126822779 | 
                                                                                                                126822802 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                27869803 | 
                                                                                                                HPAFII | 
                                                                                                                viability after 31 days | 
                                                                                                                AGGATCAACCAATGGGAGGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.46768112561349706 | 
                                                                                                                [204] | 
                                                                                                                [205,107,NaN] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10084450 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2520406538991188 | 
                                                                                                                [352] | 
                                                                                                                [493] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10185040 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.03322534573139868 | 
                                                                                                                [641] | 
                                                                                                                [771] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10185041 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.293634219700322 | 
                                                                                                                [108] | 
                                                                                                                [156] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10185042 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.13658688915507566 | 
                                                                                                                [57] | 
                                                                                                                [61] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10185043 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.03815477356083474 | 
                                                                                                                [89] | 
                                                                                                                [102] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10185044 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6170942350560531 | 
                                                                                                                [252] | 
                                                                                                                [455] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10185045 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.40579825990885077 | 
                                                                                                                [351] | 
                                                                                                                [547] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10185046 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3373911056915784 | 
                                                                                                                [142] | 
                                                                                                                [132] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10185047 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.49117668548820115 | 
                                                                                                                [490] | 
                                                                                                                [810] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10185048 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2696981361148043 | 
                                                                                                                [59] | 
                                                                                                                [84] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10185049 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                TF1 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                NaN | 
                                                                                                                [NaN] | 
                                                                                                                [144] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10354406 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                TF1 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                NaN | 
                                                                                                                [NaN] | 
                                                                                                                [453] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10354407 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                TF1 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                NaN | 
                                                                                                                [NaN] | 
                                                                                                                [166] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10354408 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                TF1 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                NaN | 
                                                                                                                [NaN] | 
                                                                                                                [64] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10354409 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                TF1 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                NaN | 
                                                                                                                [NaN] | 
                                                                                                                [90] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10354410 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                TF1 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                NaN | 
                                                                                                                [NaN] | 
                                                                                                                [490] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10354411 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                TF1 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                NaN | 
                                                                                                                [NaN] | 
                                                                                                                [299] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10354412 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                TF1 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                NaN | 
                                                                                                                [NaN] | 
                                                                                                                [242] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10354413 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                TF1 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                NaN | 
                                                                                                                [NaN] | 
                                                                                                                [621] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10354414 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                TF1 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                NaN | 
                                                                                                                [NaN] | 
                                                                                                                [48] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10354415 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.23798040680622679 | 
                                                                                                                [105] | 
                                                                                                                [220] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10523772 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.008073300535682115 | 
                                                                                                                [107] | 
                                                                                                                [191] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10523773 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.20729185390679716 | 
                                                                                                                [31] | 
                                                                                                                [48] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10523774 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.028452575489431586 | 
                                                                                                                [14] | 
                                                                                                                [25] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10523775 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.0533272441284613 | 
                                                                                                                [26] | 
                                                                                                                [22] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10523776 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.39413173284276004 | 
                                                                                                                [98] | 
                                                                                                                [229] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10523777 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.854062907254304 | 
                                                                                                                [90] | 
                                                                                                                [88] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10523778 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3402697308768716 | 
                                                                                                                [20] | 
                                                                                                                [46] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10523779 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.21613343086476555 | 
                                                                                                                [111] | 
                                                                                                                [229] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10523780 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3625700793847084 | 
                                                                                                                [15] | 
                                                                                                                [21] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10523781 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.23798040680622679 | 
                                                                                                                [105] | 
                                                                                                                [220] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10693138 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.008073300535682115 | 
                                                                                                                [107] | 
                                                                                                                [191] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10693139 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.20729185390679716 | 
                                                                                                                [31] | 
                                                                                                                [48] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10693140 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.028452575489431586 | 
                                                                                                                [14] | 
                                                                                                                [25] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10693141 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.0533272441284613 | 
                                                                                                                [26] | 
                                                                                                                [22] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10693142 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.39413173284276004 | 
                                                                                                                [98] | 
                                                                                                                [229] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10693143 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.854062907254304 | 
                                                                                                                [90] | 
                                                                                                                [88] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10693144 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3402697308768716 | 
                                                                                                                [20] | 
                                                                                                                [46] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10693145 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.21613343086476555 | 
                                                                                                                [111] | 
                                                                                                                [229] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10693146 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                SKM1 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3625700793847084 | 
                                                                                                                [15] | 
                                                                                                                [21] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10693147 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                PL21 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4264154703129962 | 
                                                                                                                [370] | 
                                                                                                                [216] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10862504 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                PL21 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.36262714011763986 | 
                                                                                                                [386] | 
                                                                                                                [130] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10862505 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                PL21 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.9064084114326099 | 
                                                                                                                [151] | 
                                                                                                                [123] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10862506 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                PL21 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.0542887480258654 | 
                                                                                                                [51] | 
                                                                                                                [46] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10862507 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                PL21 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.14900994913306642 | 
                                                                                                                [106] | 
                                                                                                                [41] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10862508 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                PL21 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8289840048312962 | 
                                                                                                                [312] | 
                                                                                                                [241] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10862509 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                PL21 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.7814818561958252 | 
                                                                                                                [311] | 
                                                                                                                [78] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10862510 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                PL21 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.5724498894076078 | 
                                                                                                                [122] | 
                                                                                                                [17] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10862511 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                PL21 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.7103343468085039 | 
                                                                                                                [329] | 
                                                                                                                [234] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10862512 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                PL21 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -4.259292004147977 | 
                                                                                                                [43] | 
                                                                                                                [0] | 
                                                                                                                -9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                10862513 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2520406538991188 | 
                                                                                                                [352] | 
                                                                                                                [493] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11031870 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.03322534573139868 | 
                                                                                                                [641] | 
                                                                                                                [771] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11031871 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.293634219700322 | 
                                                                                                                [108] | 
                                                                                                                [156] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11031872 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.13658688915507566 | 
                                                                                                                [57] | 
                                                                                                                [61] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11031873 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.03815477356083474 | 
                                                                                                                [89] | 
                                                                                                                [102] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11031874 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6170942350560531 | 
                                                                                                                [252] | 
                                                                                                                [455] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11031875 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.40579825990885077 | 
                                                                                                                [351] | 
                                                                                                                [547] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11031876 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3373911056915784 | 
                                                                                                                [142] | 
                                                                                                                [132] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11031877 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.49117668548820115 | 
                                                                                                                [490] | 
                                                                                                                [810] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11031878 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                P31FUJ | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2696981361148043 | 
                                                                                                                [59] | 
                                                                                                                [84] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11031879 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML5 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5210213804347104 | 
                                                                                                                [204] | 
                                                                                                                [530] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11201236 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML5 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2745450626681778 | 
                                                                                                                [277] | 
                                                                                                                [606] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11201237 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML5 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.7066643882839794 | 
                                                                                                                [36] | 
                                                                                                                [108] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11201238 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML5 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.0913499007696355 | 
                                                                                                                [12] | 
                                                                                                                [49] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11201239 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                OCIAML5 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.521748265688334 | 
                                                                                                                [70] | 
                                                                                                                [183] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11201240 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML5 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.616965818055576 | 
                                                                                                                [176] | 
                                                                                                                [489] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11201241 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML5 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.15871326788924578 | 
                                                                                                                [199] | 
                                                                                                                [402] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11201242 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML5 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8809945688462931 | 
                                                                                                                [73] | 
                                                                                                                [245] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11201243 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML5 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.24071007028281022 | 
                                                                                                                [270] | 
                                                                                                                [577] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11201244 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML5 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.754591000956478 | 
                                                                                                                [21] | 
                                                                                                                [66] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11201245 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                EOL1 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.11773106815035694 | 
                                                                                                                [669] | 
                                                                                                                [382] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11370602 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                EOL1 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.18280963772595726 | 
                                                                                                                [501] | 
                                                                                                                [232] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11370603 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                EOL1 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.620886364963984 | 
                                                                                                                [215] | 
                                                                                                                [73] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11370604 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                EOL1 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5755258315641087 | 
                                                                                                                [98] | 
                                                                                                                [34] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11370605 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                EOL1 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.971263378157494 | 
                                                                                                                [226] | 
                                                                                                                [60] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11370606 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                EOL1 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.17778908491058798 | 
                                                                                                                [541] | 
                                                                                                                [322] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11370607 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                EOL1 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.7715841050870942 | 
                                                                                                                [417] | 
                                                                                                                [128] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11370608 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                EOL1 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.4511769619753634 | 
                                                                                                                [142] | 
                                                                                                                [102] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11370609 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                EOL1 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5833141538863813 | 
                                                                                                                [488] | 
                                                                                                                [385] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11370610 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                EOL1 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.9234491349844158 | 
                                                                                                                [71] | 
                                                                                                                [19] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11370611 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5870005934322542 | 
                                                                                                                [487] | 
                                                                                                                [529] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11539968 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6447184315237977 | 
                                                                                                                [585] | 
                                                                                                                [270] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11539969 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5666675360227525 | 
                                                                                                                [126] | 
                                                                                                                [135] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11539970 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.07669862422010287 | 
                                                                                                                [79] | 
                                                                                                                [60] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11539971 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.2805718514594566 | 
                                                                                                                [167] | 
                                                                                                                [49] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11539972 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1582957819030904 | 
                                                                                                                [425] | 
                                                                                                                [275] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11539973 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6725096675945615 | 
                                                                                                                [398] | 
                                                                                                                [180] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11539974 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.0910779106436328 | 
                                                                                                                [164] | 
                                                                                                                [55] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11539975 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.09110254031031817 | 
                                                                                                                [522] | 
                                                                                                                [354] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11539976 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MOLM13 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8835829889567988 | 
                                                                                                                [73] | 
                                                                                                                [28] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11539977 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                HEL | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6039011355827684 | 
                                                                                                                [559] | 
                                                                                                                [235] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11709334 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                HEL | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3148997746233826 | 
                                                                                                                [427] | 
                                                                                                                [340] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11709335 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                HEL | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3649147405430782 | 
                                                                                                                [188] | 
                                                                                                                [93] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11709336 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                HEL | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.2715312939737591 | 
                                                                                                                [48] | 
                                                                                                                [25] | 
                                                                                                                -2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11709337 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                HEL | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.20053566431219 | 
                                                                                                                [182] | 
                                                                                                                [50] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11709338 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                HEL | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5806036053216154 | 
                                                                                                                [426] | 
                                                                                                                [408] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11709339 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                HEL | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1720462955327354 | 
                                                                                                                [291] | 
                                                                                                                [165] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11709340 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                HEL | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.2356941234750436 | 
                                                                                                                [119] | 
                                                                                                                [180] | 
                                                                                                                9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11709341 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                HEL | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.0061867274527641625 | 
                                                                                                                [391] | 
                                                                                                                [249] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11709342 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                HEL | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.1202219706987937 | 
                                                                                                                [55] | 
                                                                                                                [32] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11709343 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8537737022964986 | 
                                                                                                                [334] | 
                                                                                                                [509] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11878700 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.15327083960825183 | 
                                                                                                                [363] | 
                                                                                                                [340] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11878701 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.17026969026031535 | 
                                                                                                                [95] | 
                                                                                                                [90] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11878702 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.048891871400695 | 
                                                                                                                [34] | 
                                                                                                                [60] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11878703 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.03267036840996 | 
                                                                                                                [118] | 
                                                                                                                [48] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11878704 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.12832633889509992 | 
                                                                                                                [264] | 
                                                                                                                [243] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11878705 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.42730535547266624 | 
                                                                                                                [240] | 
                                                                                                                [272] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11878706 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.649535994354121 | 
                                                                                                                [83] | 
                                                                                                                [110] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11878707 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.3555213792322268 | 
                                                                                                                [362] | 
                                                                                                                [238] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11878708 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MV411 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6624750500616192 | 
                                                                                                                [35] | 
                                                                                                                [47] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                11878709 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MONOMAC1 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.3297914776768467 | 
                                                                                                                [210] | 
                                                                                                                [607] | 
                                                                                                                9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12048066 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MONOMAC1 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.388133137906463 | 
                                                                                                                [265] | 
                                                                                                                [232] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12048067 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MONOMAC1 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.1934226294986241 | 
                                                                                                                [73] | 
                                                                                                                [96] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12048068 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MONOMAC1 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.978812988339864 | 
                                                                                                                [26] | 
                                                                                                                [60] | 
                                                                                                                8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12048069 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                MONOMAC1 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.0385914014335883 | 
                                                                                                                [61] | 
                                                                                                                [72] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12048070 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MONOMAC1 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.07365443155427143 | 
                                                                                                                [223] | 
                                                                                                                [243] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12048071 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MONOMAC1 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.08217289002755068 | 
                                                                                                                [180] | 
                                                                                                                [195] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12048072 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MONOMAC1 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.8182299095937567 | 
                                                                                                                [46] | 
                                                                                                                [94] | 
                                                                                                                7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12048073 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MONOMAC1 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.16335372080326493 | 
                                                                                                                [253] | 
                                                                                                                [259] | 
                                                                                                                -1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12048074 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                MONOMAC1 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2180006522192901 | 
                                                                                                                [23] | 
                                                                                                                [31] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12048075 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.09443311804129007 | 
                                                                                                                [72] | 
                                                                                                                [431] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12217432 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5943651936644061 | 
                                                                                                                [72] | 
                                                                                                                [267] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12217433 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                1.2901825108784128 | 
                                                                                                                [17] | 
                                                                                                                [243] | 
                                                                                                                9 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12217434 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.6992951762001514 | 
                                                                                                                [9] | 
                                                                                                                [89] | 
                                                                                                                6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12217435 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.42983450120692435 | 
                                                                                                                [14] | 
                                                                                                                [111] | 
                                                                                                                4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12217436 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.38788939423422486 | 
                                                                                                                [71] | 
                                                                                                                [304] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12217437 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5240690842036217 | 
                                                                                                                [54] | 
                                                                                                                [211] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12217438 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.6632749031845568 | 
                                                                                                                [17] | 
                                                                                                                [62] | 
                                                                                                                -5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12217439 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.19450302416297816 | 
                                                                                                                [69] | 
                                                                                                                [443] | 
                                                                                                                1 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12217440 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML2 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.4706298252421612 | 
                                                                                                                [10] | 
                                                                                                                [21] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12217441 | 
                                                                            
                                                                                                        126777652 | 
                                                                                                                126777675 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                CAAGGTGCGCAGCCTGGAGACGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.9666098732826103 | 
                                                                                                                [133] | 
                                                                                                                [206] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12386798 | 
                                                                            
                                                                                                        126819071 | 
                                                                                                                126819094 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                TCTTGATGTAAAGTTAGCCCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.5449130907959935 | 
                                                                                                                [129] | 
                                                                                                                [268] | 
                                                                                                                -4 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12386799 | 
                                                                            
                                                                                                        126777694 | 
                                                                                                                126777717 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                GCAGGTGACGGAGCGCGAGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.4296208224232807 | 
                                                                                                                [28] | 
                                                                                                                [64] | 
                                                                                                                -3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12386800 | 
                                                                            
                                                                                                        126777823 | 
                                                                                                                126777846 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                CGAGCTGGGCAAGTGCAAGGCGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.2403706857094627 | 
                                                                                                                [17] | 
                                                                                                                [22] | 
                                                                                                                -7 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12386801 | 
                                                                            
                                                                                                        126810341 | 
                                                                                                                126810364 | 
                                                                                                                5 | 
                                                                                                                - | 
                                                                                                                28162770 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                GAAGAGAGCTCACTTTGGCATGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -0.8515038626165271 | 
                                                                                                                [51] | 
                                                                                                                [86] | 
                                                                                                                -6 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12386802 | 
                                                                            
                                                                                                        126822775 | 
                                                                                                                126822798 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                GTGTAGGATCAACCAATGGGAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.012649931496311995 | 
                                                                                                                [87] | 
                                                                                                                [267] | 
                                                                                                                0 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12386803 | 
                                                                            
                                                                                                        126777634 | 
                                                                                                                126777657 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                GCTGGCGGTGTACATCGACAAGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.3438868577336116 | 
                                                                                                                [88] | 
                                                                                                                [340] | 
                                                                                                                3 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12386804 | 
                                                                            
                                                                                                        126777745 | 
                                                                                                                126777768 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                GGCGCTCTACGAGACCGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.2747478263975841 | 
                                                                                                                [22] | 
                                                                                                                [83] | 
                                                                                                                2 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12386805 | 
                                                                            
                                                                                                        126810206 | 
                                                                                                                126810229 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                TGAAACGCGCTTGGTAGAGGTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                0.5059732407726045 | 
                                                                                                                [107] | 
                                                                                                                [462] | 
                                                                                                                5 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12386806 | 
                                                                            
                                                                                                        126810308 | 
                                                                                                                126810331 | 
                                                                                                                5 | 
                                                                                                                + | 
                                                                                                                28162770 | 
                                                                                                                OCIAML3 | 
                                                                                                                viability | 
                                                                                                                GAGGCTGTATAAGGAGGAGCTGG | 
                                                                                                                LMNB1 | 
                                                                                                                ENSG00000113368 | 
                                                                                                                -1.8164000616606115 | 
                                                                                                                [6] | 
                                                                                                                [5] | 
                                                                                                                -8 | 
                                                                                                                hSpCas9 | 
                                                                                                                negative selection | 
                                                                                                                12386807 |