Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 4669
• Symbol: NAGLU
• Description: N-acetyl-alpha-glucosaminidase

DataSource: http://genomecrispr.dkfz.de/#!/results/NAGLU

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
42536263	42536286	17	+	26472758	Jiyoye	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	1.5372359220702465	[52]	[115]	8	hSpCas9	negative selection	105559
42536402	42536425	17	-	26472758	Jiyoye	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	1.01231576416466	[141]	[215]	6	hSpCas9	negative selection	105560
42536453	42536476	17	+	26472758	Jiyoye	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	-0.9713362417478566	[142]	[54]	-6	hSpCas9	negative selection	105561
42536263	42536286	17	+	26472758	KBM7	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	-0.33469327986424746	[338,246]	[135,82]	-3	hSpCas9	negative selection	296677
42536402	42536425	17	-	26472758	KBM7	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.7452767667671556	[979,735]	[797,554]	7	hSpCas9	negative selection	296678
42536453	42536476	17	+	26472758	KBM7	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	0.088030918997135	[228,284]	[139,121]	0	hSpCas9	negative selection	296679
42536263	42536286	17	+	26472758	Raji	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	-0.34327787363596585	[163]	[29]	-3	hSpCas9	negative selection	487795
42536402	42536425	17	-	26472758	Raji	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-0.6415547004586827	[483]	[71]	-5	hSpCas9	negative selection	487796
42536453	42536476	17	+	26472758	Raji	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	-0.6523533664512646	[148]	[21]	-5	hSpCas9	negative selection	487797
42536263	42536286	17	+	26472758	K562	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	-0.9956323601665079	[273]	[115]	-5	hSpCas9	negative selection	678913
42536402	42536425	17	-	26472758	K562	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.6105011521600461	[546]	[704]	5	hSpCas9	negative selection	678914
42536453	42536476	17	+	26472758	K562	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	0.3606117451709696	[154]	[167]	3	hSpCas9	negative selection	678915
42536402	42536425	17	-	26627737	DLD1	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	1.582680913240228	[144]	[197,143,74]	9	hSpCas9	negative selection	797862
42536402	42536425	17	-	26627737	GBM cells	viability after 5 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.35459335866187525	[34]	[21,25]	5	hSpCas9	negative selection	880177
42536402	42536425	17	-	26627737	GBM cells	viability after 13 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.8154218444646109	[34]	[44,23]	8	hSpCas9	negative selection	962492
42536402	42536425	17	-	26627737	GBM cells	viability after 21 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-2.889153772242926	[34]	[0,3]	-9	hSpCas9	negative selection	1044807
42536402	42536425	17	-	26627737	RPE1	viability after 9 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.07334698539146367	[296]	[75,125]	0	hSpCas9	negative selection	1127122
42536402	42536425	17	-	26627737	RPE1	viability after 12 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.31198139513023926	[296]	[117,78]	2	hSpCas9	negative selection	1209437
42536402	42536425	17	-	26627737	RPE1	viability after 15 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	1.0791049674631732	[296]	[289,68]	6	hSpCas9	negative selection	1291752
42536402	42536425	17	-	26627737	RPE1	viability after 18 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-0.7721001254635165	[296]	[44,48]	-5	hSpCas9	negative selection	1374067
42536402	42536425	17	-	26627737	HeLa	viability after 8 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-3.5931264427978205	[255]	[6,7,11]	-9	hSpCas9	negative selection	1456382
42536402	42536425	17	-	26627737	HeLa	viability after 12 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-1.44654418727565	[255]	[13,73,23]	-8	hSpCas9	negative selection	1538697
42536402	42536425	17	-	26627737	HeLa	viability after 15 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-1.0808525004854972	[255]	[50,56,38]	-7	hSpCas9	negative selection	1621012
42536402	42536425	17	-	26627737	HeLa	viability after 18 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-0.9455530345003688	[255]	[42,47,38]	-7	hSpCas9	negative selection	1703327
42536402	42536425	17	-	26627737	HCT116	viability after 6 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-1.9110315793790076	[227]	[24,0]	-8	hSpCas9	negative selection	1785642
42536402	42536425	17	-	26627737	HCT116	viability after 8 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-0.7782373191804546	[81]	[68,0,9]	-7	hSpCas9	negative selection	1867957
42536402	42536425	17	-	26627737	HCT116	viability after 9 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.16889803674444992	[227]	[68,67]	1	hSpCas9	negative selection	1950272
42536402	42536425	17	-	26627737	HCT116	viability after 12 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.44714292068367323	[81]	[74,65,33]	4	hSpCas9	negative selection	2032587
42536402	42536425	17	-	26627737	HCT116	viability after 15 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.21827937271462328	[81]	[97,48,22]	2	hSpCas9	negative selection	2114902
42536402	42536425	17	-	26627737	HCT116	viability after 18 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.9481646059626043	[81]	[99,27,105]	7	hSpCas9	negative selection	2197217
42536401	42536424	17	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ACACGGAGAAGTCGGCCGCGGGG	NAGLU	ENSG00000108784	-0.3621513028652332	[2,3]	[1,1]	-5	hSpCas9	positive selection	3004565
42536401	42536424	17	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ACACGGAGAAGTCGGCCGCGGGG	NAGLU	ENSG00000108784	0.054830383625461	[2,2]	[3,1]	1	hSpCas9	positive selection	3072423
42536401	42536424	17	-	26780180	HT29	viability (Avana library 4 designs)	ACACGGAGAAGTCGGCCGCGGGG	NAGLU	ENSG00000108784	1.09749849015607	[]	[]	4	hSpCas9	negative selection	3442391
42536401	42536424	17	-	26780180	A375	viability (Avana lentiCRISPRv2)	ACACGGAGAAGTCGGCCGCGGGG	NAGLU	ENSG00000108784	4.51855733498994	[]	[]	7	hSpCas9	negative selection	3533564
42536401	42536424	17	-	26780180	A375	viability (Avana lentiGuide)	ACACGGAGAAGTCGGCCGCGGGG	NAGLU	ENSG00000108784	1.70232262569782	[]	[]	2	hSpCas9	negative selection	3642223
42536401	42536424	17	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ACACGGAGAAGTCGGCCGCGGGG	NAGLU	ENSG00000108784	0.06524757319377841	[3]	[4,3]	1	hSpCas9	positive selection	3750882
42536401	42536424	17	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ACACGGAGAAGTCGGCCGCGGGG	NAGLU	ENSG00000108784	-0.13183575457187274	[5]	[4,3]	-2	hSpCas9	positive selection	3859489
42536408	42536430	17	+	27760321	OCIAML3	viability	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	0.3791611450585428	[1259,935]	[882,1398]	4	hSpCas9	negative selection	4421042
42536408	42536430	17	+	27760321	OCIAML2	viability	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	0.011671362208430569	[1259,935]	[827,965]	0	hSpCas9	negative selection	4504505
42536408	42536430	17	+	27760321	MV411	viability	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	0.2534982456030077	[1259,935]	[533,1339]	1	hSpCas9	negative selection	4587968
42536408	42536430	17	+	27760321	HL60	viability	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	-0.08714455736862492	[1259,935]	[783,892]	-1	hSpCas9	negative selection	4671431
42536408	42536430	17	+	27760321	HT1080	viability	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	0.4670038928119984	[935,730]	[310,620]	2	hSpCas9	negative selection	4754894
42536408	42536430	17	+	27760321	HT29	viability after 7 days	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	0.39353962670277576	[935,730]	[1764,1123,1383]	6	hSpCas9	negative selection	4838357
42536408	42536430	17	+	27760321	HT29	viability after 25 days	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	0.3494204157287524	[935,730]	[1193,950,1527]	4	hSpCas9	negative selection	4921820
42536408	42536430	17	+	27760321	HT29	viability after 22 days	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	0.4121572713121122	[935,730]	[1499,1246,1091]	4	hSpCas9	negative selection	5005283
42536408	42536430	17	+	27760321	HT29	viability after 19 days	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	0.4466712368749499	[935,730]	[1550,826,1535]	4	hSpCas9	negative selection	5088746
42536408	42536430	17	+	27760321	HT29	viability after 16 days	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	0.44202457243427595	[935,730]	[1493,957,1377]	5	hSpCas9	negative selection	5172209
42536408	42536430	17	+	27760321	HT29	viability after 13 days	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	0.28947269340953796	[935,730]	[1092,1363,1093]	3	hSpCas9	negative selection	5255672
42536408	42536430	17	+	27760321	HT29	viability after 10 days	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	0.37094043374261476	[935,730]	[1408,1190,1430]	5	hSpCas9	negative selection	5339135
42536408	42536430	17	+	27760321	MOLM13	viability	GCCGACTTCTCCGTGTCGGTGG	NAGLU	ENSG00000108784	2.8940376958255776	[1259,935]	[9388,456]	9	hSpCas9	negative selection	5422598
42536292	42536315	17	-	27661255	K562	viability	GAGAAGGACCCCCACCGCCGCGG	NAGLU	ENSG00000108784	0.02085994951810144	[1645,1948]	[1616,1311]	0	dCas9-KRAB	negative selection	5495462
42536402	42536425	17	-	27869803	HPAFII	viability after 27 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	1.0671865216712855	[50]	[119,2,NaN]	8	hSpCas9	negative selection	9560880
42536402	42536425	17	-	27869803	HPAFII	viability after 15 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.8439173603410752	[50]	[254,0,NaN]	8	hSpCas9	negative selection	9643329
42536402	42536425	17	-	27869803	ASPC1	viability after 36 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	1.2090209082726582	[174]	[471,0,18]	9	hSpCas9	negative selection	9725778
42536402	42536425	17	-	27869803	PATU8988S	viability after 35 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-1.802339416594585	[103]	[15,7,NaN]	-8	hSpCas9	negative selection	9808227
42536402	42536425	17	-	27869803	PATU8988S	viability after 31 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-2.4866241001567446	[103]	[2,12,NaN]	-9	hSpCas9	negative selection	9890676
42536402	42536425	17	-	27869803	HPAFII	viability after 35 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.8828164094567026	[50]	[88,0,NaN]	6	hSpCas9	negative selection	9973125
42536402	42536425	17	-	27869803	HPAFII	viability after 31 days	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.6123924923577535	[50]	[82,0,NaN]	4	hSpCas9	negative selection	10055574
42536263	42536286	17	+	28162770	P31FUJ	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	-0.15188220903081112	[155]	[164]	-1	hSpCas9	negative selection	10197516
42536402	42536425	17	-	28162770	P31FUJ	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.3439863648610774	[294]	[439]	4	hSpCas9	negative selection	10197517
42536453	42536476	17	+	28162770	P31FUJ	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	-0.4489356352791444	[114]	[98]	-4	hSpCas9	negative selection	10197518
42536263	42536286	17	+	28162770	TF1	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	NaN	[NaN]	[64]	1	hSpCas9	negative selection	10366882
42536402	42536425	17	-	28162770	TF1	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	NaN	[NaN]	[210]	1	hSpCas9	negative selection	10366883
42536453	42536476	17	+	28162770	TF1	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	NaN	[NaN]	[102]	1	hSpCas9	negative selection	10366884
42536263	42536286	17	+	28162770	SKM1	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	-0.036126503374853014	[28]	[49]	0	hSpCas9	negative selection	10536248
42536402	42536425	17	-	28162770	SKM1	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-0.6685272173602873	[97]	[108]	-5	hSpCas9	negative selection	10536249
42536453	42536476	17	+	28162770	SKM1	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	0.8615246371827403	[32]	[105]	7	hSpCas9	negative selection	10536250
42536263	42536286	17	+	28162770	SKM1	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	-0.036126503374853014	[28]	[49]	0	hSpCas9	negative selection	10705614
42536402	42536425	17	-	28162770	SKM1	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-0.6685272173602873	[97]	[108]	-5	hSpCas9	negative selection	10705615
42536453	42536476	17	+	28162770	SKM1	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	0.8615246371827403	[32]	[105]	7	hSpCas9	negative selection	10705616
42536263	42536286	17	+	28162770	PL21	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	-0.37359563080858205	[127]	[42]	-3	hSpCas9	negative selection	10874980
42536402	42536425	17	-	28162770	PL21	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.09997545256388818	[327]	[152]	0	hSpCas9	negative selection	10874981
42536453	42536476	17	+	28162770	PL21	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	-1.9697853869529922	[116]	[12]	-8	hSpCas9	negative selection	10874982
42536263	42536286	17	+	28162770	P31FUJ	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	-0.15188220903081112	[155]	[164]	-1	hSpCas9	negative selection	11044346
42536402	42536425	17	-	28162770	P31FUJ	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.3439863648610774	[294]	[439]	4	hSpCas9	negative selection	11044347
42536453	42536476	17	+	28162770	P31FUJ	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	-0.4489356352791444	[114]	[98]	-4	hSpCas9	negative selection	11044348
42536263	42536286	17	+	28162770	OCIAML5	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	-0.22757570595620336	[47]	[73]	-2	hSpCas9	negative selection	11213712
42536402	42536425	17	-	28162770	OCIAML5	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.39889500266922195	[149]	[356]	3	hSpCas9	negative selection	11213713
42536453	42536476	17	+	28162770	OCIAML5	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	0.008957015987192507	[97]	[177]	0	hSpCas9	negative selection	11213714
42536263	42536286	17	+	28162770	EOL1	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	-1.1389551707356236	[208]	[49]	-6	hSpCas9	negative selection	11383078
42536402	42536425	17	-	28162770	EOL1	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.5824731035713959	[648]	[511]	5	hSpCas9	negative selection	11383079
42536453	42536476	17	+	28162770	EOL1	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	0.4703718783847325	[136]	[99]	4	hSpCas9	negative selection	11383080
42536263	42536286	17	+	28162770	MOLM13	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	0.02588483466546576	[143]	[105]	0	hSpCas9	negative selection	11552444
42536402	42536425	17	-	28162770	MOLM13	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.9558901523786469	[399]	[560]	7	hSpCas9	negative selection	11552445
42536453	42536476	17	+	28162770	MOLM13	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	-0.8122185376481565	[203]	[83]	-4	hSpCas9	negative selection	11552446
42536263	42536286	17	+	28162770	HEL	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	0.5084377402887659	[134]	[122]	4	hSpCas9	negative selection	11721810
42536402	42536425	17	-	28162770	HEL	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.6952062518944924	[431]	[447]	6	hSpCas9	negative selection	11721811
42536453	42536476	17	+	28162770	HEL	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	-1.60703947713117	[194]	[40]	-7	hSpCas9	negative selection	11721812
42536263	42536286	17	+	28162770	MV411	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	-0.26881219985436655	[122]	[85]	-2	hSpCas9	negative selection	11891176
42536402	42536425	17	-	28162770	MV411	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-0.4579139388392664	[330]	[202]	-3	hSpCas9	negative selection	11891177
42536453	42536476	17	+	28162770	MV411	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	1.1283848791390119	[100]	[185]	8	hSpCas9	negative selection	11891178
42536263	42536286	17	+	28162770	MONOMAC1	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	0.7041849984622727	[67]	[126]	6	hSpCas9	negative selection	12060542
42536402	42536425	17	-	28162770	MONOMAC1	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.07575652523656873	[220]	[266]	0	hSpCas9	negative selection	12060543
42536453	42536476	17	+	28162770	MONOMAC1	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	-0.40725455444989933	[58]	[50]	-4	hSpCas9	negative selection	12060544
42536263	42536286	17	+	28162770	OCIAML2	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	-0.8076648125197317	[17]	[56]	-5	hSpCas9	negative selection	12229908
42536402	42536425	17	-	28162770	OCIAML2	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	-0.37232775163035725	[77]	[333]	-3	hSpCas9	negative selection	12229909
42536453	42536476	17	+	28162770	OCIAML2	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	-0.287408001186391	[23]	[108]	-2	hSpCas9	negative selection	12229910
42536263	42536286	17	+	28162770	OCIAML3	viability	GACTGAGACCATGGAGGCGGTGG	NAGLU	ENSG00000108784	1.3293710780729244	[28]	[219]	9	hSpCas9	negative selection	12399274
42536402	42536425	17	-	28162770	OCIAML3	viability	GACACGGAGAAGTCGGCCGCGGG	NAGLU	ENSG00000108784	0.29843921852103317	[86]	[322]	3	hSpCas9	negative selection	12399275
42536453	42536476	17	+	28162770	OCIAML3	viability	GGCTTGGACACCTACAGCCTGGG	NAGLU	ENSG00000108784	-0.35522078073704666	[24]	[58]	-3	hSpCas9	negative selection	12399276