Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 10133
• Symbol: OPTN
• Description: optineurin

DataSource: http://genomecrispr.dkfz.de/#!/results/OPTN

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
13112457	13112480	10	-	26472758	Jiyoye	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	0.29066137277944837	[115]	[106]	2	hSpCas9	negative selection	113971
13110326	13110349	10	+	26472758	Jiyoye	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	-1.9503766231122104	[40]	[7]	-8	hSpCas9	negative selection	113972
13112503	13112526	10	+	26472758	Jiyoye	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	0.020152258396626266	[16]	[12]	0	hSpCas9	negative selection	113973
13112524	13112547	10	+	26472758	Jiyoye	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	0.9921378822270296	[125]	[188]	6	hSpCas9	negative selection	113974
13122421	13122444	10	+	26472758	Jiyoye	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	-0.03372028569399599	[318]	[234]	0	hSpCas9	negative selection	113975
13122460	13122483	10	+	26472758	Jiyoye	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	0.929853603972687	[70]	[101]	6	hSpCas9	negative selection	113976
13132172	13132195	10	+	26472758	Jiyoye	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	-0.9818669092400261	[54]	[20]	-6	hSpCas9	negative selection	113977
13109140	13109163	10	+	26472758	Jiyoye	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	-0.16507606746572884	[112]	[75]	-1	hSpCas9	negative selection	113978
13109162	13109185	10	+	26472758	Jiyoye	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	-0.3198061240877106	[47]	[28]	-2	hSpCas9	negative selection	113979
13109229	13109252	10	-	26472758	Jiyoye	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	4.107615099646965	[0]	[12]	9	hSpCas9	negative selection	113980
13112457	13112480	10	-	26472758	KBM7	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	-0.3440758936264009	[242,271]	[154,43]	-3	hSpCas9	negative selection	305089
13110326	13110349	10	+	26472758	KBM7	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	0.4201160334666141	[23,54]	[35,16]	4	hSpCas9	negative selection	305090
13112503	13112526	10	+	26472758	KBM7	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-2.8716192867588415	[154,132]	[4,12]	-9	hSpCas9	negative selection	305091
13112524	13112547	10	+	26472758	KBM7	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	-0.22854181288235054	[826,638]	[277,303]	-2	hSpCas9	negative selection	305092
13122421	13122444	10	+	26472758	KBM7	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	-0.027603766271646735	[885,595]	[371,304]	0	hSpCas9	negative selection	305093
13122460	13122483	10	+	26472758	KBM7	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	0.2980504405385537	[316,150]	[224,46]	3	hSpCas9	negative selection	305094
13132172	13132195	10	+	26472758	KBM7	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	1.6047345486847784	[193,96]	[239,167]	9	hSpCas9	negative selection	305095
13109140	13109163	10	+	26472758	KBM7	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	0.05602895260694228	[573,460]	[168,324]	0	hSpCas9	negative selection	305096
13109162	13109185	10	+	26472758	KBM7	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	0.7521776103994389	[190,137]	[170,90]	8	hSpCas9	negative selection	305097
13109229	13109252	10	-	26472758	KBM7	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	-0.5423516086656157	[50,58]	[8,25]	-5	hSpCas9	negative selection	305098
13112457	13112480	10	-	26472758	Raji	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	0.7150661125948392	[125]	[47]	6	hSpCas9	negative selection	496207
13110326	13110349	10	+	26472758	Raji	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	0.39117650137419036	[22]	[6]	4	hSpCas9	negative selection	496208
13112503	13112526	10	+	26472758	Raji	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-3.352048083263698	[43]	[0]	-9	hSpCas9	negative selection	496209
13112524	13112547	10	+	26472758	Raji	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	-0.16038878946685747	[365]	[75]	-1	hSpCas9	negative selection	496210
13122421	13122444	10	+	26472758	Raji	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	0.23291441745745844	[428]	[116]	2	hSpCas9	negative selection	496211
13122460	13122483	10	+	26472758	Raji	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	1.3000286133159953	[83]	[47]	9	hSpCas9	negative selection	496212
13132172	13132195	10	+	26472758	Raji	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	0.9498422583871196	[86]	[38]	8	hSpCas9	negative selection	496213
13109140	13109163	10	+	26472758	Raji	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	0.5653296261217344	[264]	[90]	5	hSpCas9	negative selection	496214
13109162	13109185	10	+	26472758	Raji	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	-1.0478946901043114	[97]	[10]	-6	hSpCas9	negative selection	496215
13109229	13109252	10	-	26472758	Raji	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	1.6219567082033572	[13]	[9]	9	hSpCas9	negative selection	496216
13112457	13112480	10	-	26472758	K562	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	-0.28743243659514695	[239]	[165]	-2	hSpCas9	negative selection	687325
13110326	13110349	10	+	26472758	K562	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	-4.965034637962502	[36]	[0]	-9	hSpCas9	negative selection	687326
13112503	13112526	10	+	26472758	K562	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-6.469826789999675	[104]	[0]	-9	hSpCas9	negative selection	687327
13112524	13112547	10	+	26472758	K562	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	0.7380979154256757	[771]	[1086]	6	hSpCas9	negative selection	687328
13122421	13122444	10	+	26472758	K562	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	0.050524022066113616	[659]	[576]	0	hSpCas9	negative selection	687329
13122460	13122483	10	+	26472758	K562	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	-0.936911037048115	[253]	[111]	-5	hSpCas9	negative selection	687330
13132172	13132195	10	+	26472758	K562	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	-0.27141941239988876	[162]	[113]	-2	hSpCas9	negative selection	687331
13109140	13109163	10	+	26472758	K562	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	-0.37415216569752896	[455]	[296]	-2	hSpCas9	negative selection	687332
13109162	13109185	10	+	26472758	K562	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	0.9320344054499556	[112]	[181]	7	hSpCas9	negative selection	687333
13109229	13109252	10	-	26472758	K562	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	0.1595298300799337	[34]	[32]	1	hSpCas9	negative selection	687334
13109200	13109223	10	-	26627737	DLD1	viability	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	1.127054122532722	[310]	[132,395,128]	9	hSpCas9	negative selection	774258
13110310	13110333	10	+	26627737	DLD1	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.21513220624587825	[106]	[57,26,31]	2	hSpCas9	negative selection	774259
13112518	13112541	10	-	26627737	DLD1	viability	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.7125056796366137	[530]	[349,263,210]	7	hSpCas9	negative selection	774260
13116315	13116338	10	+	26627737	DLD1	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	0.19947961264124892	[427]	[216,110,133]	2	hSpCas9	negative selection	774264
13119008	13119031	10	+	26627737	DLD1	viability	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.2007254402576674	[529]	[154,204,208]	2	hSpCas9	negative selection	774265
13123988	13124011	10	+	26627737	DLD1	viability	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.41957402993944093	[282]	[120,98,131]	4	hSpCas9	negative selection	774266
13109200	13109223	10	-	26627737	GBM cells	viability after 5 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	-0.29465571128500856	[222]	[108,85]	-4	hSpCas9	negative selection	856573
13110310	13110333	10	+	26627737	GBM cells	viability after 5 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-0.07723938315994694	[59]	[28,31]	-1	hSpCas9	negative selection	856574
13112518	13112541	10	-	26627737	GBM cells	viability after 5 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.019929275847051477	[239]	[151,108]	0	hSpCas9	negative selection	856575
13116315	13116338	10	+	26627737	GBM cells	viability after 5 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.19919621056416212	[288]	[95,173]	-3	hSpCas9	negative selection	856579
13119008	13119031	10	+	26627737	GBM cells	viability after 5 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.1590366852995763	[247]	[169,126]	2	hSpCas9	negative selection	856580
13123988	13124011	10	+	26627737	GBM cells	viability after 5 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	-0.5511705714923589	[249]	[71,110]	-7	hSpCas9	negative selection	856581
13109200	13109223	10	-	26627737	GBM cells	viability after 13 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	-0.14459109697860972	[222]	[125,95]	-2	hSpCas9	negative selection	938888
13110310	13110333	10	+	26627737	GBM cells	viability after 13 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.4566558412216728	[59]	[15,67]	6	hSpCas9	negative selection	938889
13112518	13112541	10	-	26627737	GBM cells	viability after 13 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.37602919334946067	[239]	[152,181]	5	hSpCas9	negative selection	938890
13116315	13116338	10	+	26627737	GBM cells	viability after 13 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.716060359334642	[288]	[111,81]	-7	hSpCas9	negative selection	938894
13119008	13119031	10	+	26627737	GBM cells	viability after 13 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.11351104766332668	[247]	[192,106]	1	hSpCas9	negative selection	938895
13123988	13124011	10	+	26627737	GBM cells	viability after 13 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	-0.06687287339708563	[249]	[166,98]	-1	hSpCas9	negative selection	938896
13109200	13109223	10	-	26627737	GBM cells	viability after 21 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	-0.01738725824850676	[222]	[114,123]	0	hSpCas9	negative selection	1021203
13110310	13110333	10	+	26627737	GBM cells	viability after 21 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.5942548895627815	[59]	[55,42]	6	hSpCas9	negative selection	1021204
13112518	13112541	10	-	26627737	GBM cells	viability after 21 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.5741641744026987	[239]	[202,185]	6	hSpCas9	negative selection	1021205
13116315	13116338	10	+	26627737	GBM cells	viability after 21 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.5669231621435319	[288]	[117,94]	-5	hSpCas9	negative selection	1021209
13119008	13119031	10	+	26627737	GBM cells	viability after 21 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.15303780780974377	[247]	[165,134]	1	hSpCas9	negative selection	1021210
13123988	13124011	10	+	26627737	GBM cells	viability after 21 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.04990179913874433	[249]	[149,131]	0	hSpCas9	negative selection	1021211
13109200	13109223	10	-	26627737	RPE1	viability after 9 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	0.43523299728771414	[508]	[197,237]	3	hSpCas9	negative selection	1103518
13110310	13110333	10	+	26627737	RPE1	viability after 9 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-0.7609099629739459	[417]	[33,132]	-5	hSpCas9	negative selection	1103519
13112518	13112541	10	-	26627737	RPE1	viability after 9 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	-0.6108354639147852	[1004]	[219,187]	-4	hSpCas9	negative selection	1103520
13116315	13116338	10	+	26627737	RPE1	viability after 9 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.4471885870388951	[1531]	[432,246]	-3	hSpCas9	negative selection	1103524
13119008	13119031	10	+	26627737	RPE1	viability after 9 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.07636628208862789	[1010]	[348,313]	0	hSpCas9	negative selection	1103525
13123988	13124011	10	+	26627737	RPE1	viability after 9 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.020288123111669887	[561]	[177,178]	0	hSpCas9	negative selection	1103526
13109200	13109223	10	-	26627737	RPE1	viability after 12 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	0.4401982179385643	[508]	[152,219]	3	hSpCas9	negative selection	1185833
13110310	13110333	10	+	26627737	RPE1	viability after 12 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-0.4918981696221588	[417]	[91,66]	-3	hSpCas9	negative selection	1185834
13112518	13112541	10	-	26627737	RPE1	viability after 12 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	-0.3534268308904454	[1004]	[239,180]	-2	hSpCas9	negative selection	1185835
13116315	13116338	10	+	26627737	RPE1	viability after 12 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.43675493922600095	[1531]	[272,336]	-3	hSpCas9	negative selection	1185839
13119008	13119031	10	+	26627737	RPE1	viability after 12 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-0.22871911411076734	[1010]	[190,274]	-1	hSpCas9	negative selection	1185840
13123988	13124011	10	+	26627737	RPE1	viability after 12 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.23950116860079745	[561]	[152,204]	1	hSpCas9	negative selection	1185841
13109200	13109223	10	-	26627737	RPE1	viability after 15 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	-0.2800109388921639	[508]	[141,95]	-2	hSpCas9	negative selection	1268148
13110310	13110333	10	+	26627737	RPE1	viability after 15 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-1.2793851115073829	[417]	[92,5]	-7	hSpCas9	negative selection	1268149
13112518	13112541	10	-	26627737	RPE1	viability after 15 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	-1.0685520172253482	[1004]	[188,83]	-6	hSpCas9	negative selection	1268150
13116315	13116338	10	+	26627737	RPE1	viability after 15 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.8862581600957841	[1531]	[292,177]	-5	hSpCas9	negative selection	1268154
13119008	13119031	10	+	26627737	RPE1	viability after 15 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.16338413000628094	[1010]	[219,416]	1	hSpCas9	negative selection	1268155
13123988	13124011	10	+	26627737	RPE1	viability after 15 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	-0.41476356395935204	[561]	[132,105]	-3	hSpCas9	negative selection	1268156
13109200	13109223	10	-	26627737	RPE1	viability after 18 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	0.8503563008795568	[508]	[193,304]	5	hSpCas9	negative selection	1350463
13110310	13110333	10	+	26627737	RPE1	viability after 18 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-1.3120768360683628	[417]	[57,31]	-7	hSpCas9	negative selection	1350464
13112518	13112541	10	-	26627737	RPE1	viability after 18 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	-0.41528357330910537	[1004]	[228,175]	-3	hSpCas9	negative selection	1350465
13116315	13116338	10	+	26627737	RPE1	viability after 18 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	0.059345292117558124	[1531]	[628,218]	0	hSpCas9	negative selection	1350469
13119008	13119031	10	+	26627737	RPE1	viability after 18 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.04323276683253563	[1010]	[255,307]	0	hSpCas9	negative selection	1350470
13123988	13124011	10	+	26627737	RPE1	viability after 18 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.3444360029772031	[561]	[208,174]	2	hSpCas9	negative selection	1350471
13109200	13109223	10	-	26627737	HeLa	viability after 8 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	0.21929562747591366	[316]	[150,128,196]	2	hSpCas9	negative selection	1432778
13110310	13110333	10	+	26627737	HeLa	viability after 8 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-2.8369839625742923	[110]	[13,2,4]	-9	hSpCas9	negative selection	1432779
13112518	13112541	10	-	26627737	HeLa	viability after 8 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	-0.24517698437722146	[352]	[156,184,57]	-2	hSpCas9	negative selection	1432780
13116315	13116338	10	+	26627737	HeLa	viability after 8 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	1.0135291252390246	[165]	[226,32,191]	7	hSpCas9	negative selection	1432784
13119008	13119031	10	+	26627737	HeLa	viability after 8 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-0.7573424441936325	[336]	[109,77,77]	-6	hSpCas9	negative selection	1432785
13123988	13124011	10	+	26627737	HeLa	viability after 8 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.04648530535909911	[370]	[151,208,137]	0	hSpCas9	negative selection	1432786
13109200	13109223	10	-	26627737	HeLa	viability after 12 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	0.4330034777593751	[316]	[168,217,138]	3	hSpCas9	negative selection	1515093
13110310	13110333	10	+	26627737	HeLa	viability after 12 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.12553132658039834	[110]	[93,34,23]	1	hSpCas9	negative selection	1515094
13112518	13112541	10	-	26627737	HeLa	viability after 12 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	-0.02234876786891632	[352]	[20,297,91]	0	hSpCas9	negative selection	1515095
13116315	13116338	10	+	26627737	HeLa	viability after 12 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	0.5483202810624492	[165]	[84,142,67]	4	hSpCas9	negative selection	1515099
13119008	13119031	10	+	26627737	HeLa	viability after 12 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-0.049684629711060385	[336]	[122,165,110]	0	hSpCas9	negative selection	1515100
13123988	13124011	10	+	26627737	HeLa	viability after 12 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.038917365908670246	[370]	[149,169,150]	0	hSpCas9	negative selection	1515101
13109200	13109223	10	-	26627737	HeLa	viability after 15 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	0.16084470550342367	[316]	[91,178,163]	1	hSpCas9	negative selection	1597408
13110310	13110333	10	+	26627737	HeLa	viability after 15 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-0.5540598679053175	[110]	[10,69,9]	-5	hSpCas9	negative selection	1597409
13112518	13112541	10	-	26627737	HeLa	viability after 15 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.659888618067024	[352]	[190,258,231]	5	hSpCas9	negative selection	1597410
13116315	13116338	10	+	26627737	HeLa	viability after 15 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	1.4370605493541446	[165]	[154,202,191]	8	hSpCas9	negative selection	1597414
13119008	13119031	10	+	26627737	HeLa	viability after 15 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-1.320335025919347	[336]	[34,75,53]	-8	hSpCas9	negative selection	1597415
13123988	13124011	10	+	26627737	HeLa	viability after 15 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.07010575093336499	[370]	[170,139,164]	0	hSpCas9	negative selection	1597416
13109200	13109223	10	-	26627737	HeLa	viability after 18 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	0.17464713252298797	[316]	[62,149,163]	1	hSpCas9	negative selection	1679723
13110310	13110333	10	+	26627737	HeLa	viability after 18 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-0.6422511111739135	[110]	[6,53,9]	-5	hSpCas9	negative selection	1679724
13112518	13112541	10	-	26627737	HeLa	viability after 18 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.6437211105200391	[352]	[125,210,231]	5	hSpCas9	negative selection	1679725
13116315	13116338	10	+	26627737	HeLa	viability after 18 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	1.46248718892034	[165]	[111,165,191]	8	hSpCas9	negative selection	1679729
13119008	13119031	10	+	26627737	HeLa	viability after 18 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-1.3813861087224077	[336]	[18,62,53]	-8	hSpCas9	negative selection	1679730
13123988	13124011	10	+	26627737	HeLa	viability after 18 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.0790855419674767	[370]	[118,112,164]	0	hSpCas9	negative selection	1679731
13109200	13109223	10	-	26627737	HCT116	viability after 6 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	0.46642160726325266	[242]	[26,66]	2	hSpCas9	negative selection	1762038
13110310	13110333	10	+	26627737	HCT116	viability after 6 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-1.947502271704883	[144]	[12,1]	-8	hSpCas9	negative selection	1762039
13112518	13112541	10	-	26627737	HCT116	viability after 6 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	1.0097967894320155	[614]	[97,247]	5	hSpCas9	negative selection	1762040
13116315	13116338	10	+	26627737	HCT116	viability after 6 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	2.000076063482317	[257]	[285,93]	8	hSpCas9	negative selection	1762044
13119008	13119031	10	+	26627737	HCT116	viability after 6 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-0.7146355722933365	[356]	[39,30]	-4	hSpCas9	negative selection	1762045
13123988	13124011	10	+	26627737	HCT116	viability after 6 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	-1.4080703131456236	[658]	[78,16]	-7	hSpCas9	negative selection	1762046
13109200	13109223	10	-	26627737	HCT116	viability after 8 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	-0.042639001121557996	[267]	[94,251,82]	0	hSpCas9	negative selection	1844353
13110310	13110333	10	+	26627737	HCT116	viability after 8 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	1.1593226044239573	[41]	[29,98,25]	8	hSpCas9	negative selection	1844354
13112518	13112541	10	-	26627737	HCT116	viability after 8 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.9758119850595416	[236]	[254,299,215]	8	hSpCas9	negative selection	1844355
13116315	13116338	10	+	26627737	HCT116	viability after 8 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	0.21451411652391827	[180]	[178,110,58]	2	hSpCas9	negative selection	1844359
13119008	13119031	10	+	26627737	HCT116	viability after 8 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-0.00760980426251523	[319]	[192,197,135]	0	hSpCas9	negative selection	1844360
13123988	13124011	10	+	26627737	HCT116	viability after 8 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	-0.13462726563987557	[341]	[188,212,113]	-1	hSpCas9	negative selection	1844361
13109200	13109223	10	-	26627737	HCT116	viability after 9 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	1.814320897997445	[242]	[149,289]	9	hSpCas9	negative selection	1926668
13110310	13110333	10	+	26627737	HCT116	viability after 9 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-2.053920092624884	[144]	[10,7]	-8	hSpCas9	negative selection	1926669
13112518	13112541	10	-	26627737	HCT116	viability after 9 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.9336356231342469	[614]	[292,329]	6	hSpCas9	negative selection	1926670
13116315	13116338	10	+	26627737	HCT116	viability after 9 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	1.5108576775921798	[257]	[259,145]	8	hSpCas9	negative selection	1926674
13119008	13119031	10	+	26627737	HCT116	viability after 9 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-0.3856782478606432	[356]	[120,34]	-3	hSpCas9	negative selection	1926675
13123988	13124011	10	+	26627737	HCT116	viability after 9 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	-0.12822796553996615	[658]	[98,209]	-1	hSpCas9	negative selection	1926676
13109200	13109223	10	-	26627737	HCT116	viability after 12 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	0.24305395811078584	[267]	[147,137,214]	2	hSpCas9	negative selection	2008983
13110310	13110333	10	+	26627737	HCT116	viability after 12 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.5584697156047187	[41]	[10,56,31]	5	hSpCas9	negative selection	2008984
13112518	13112541	10	-	26627737	HCT116	viability after 12 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.9966220896678093	[236]	[203,311,234]	8	hSpCas9	negative selection	2008985
13116315	13116338	10	+	26627737	HCT116	viability after 12 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	0.060241242016593644	[180]	[88,122,86]	0	hSpCas9	negative selection	2008989
13119008	13119031	10	+	26627737	HCT116	viability after 12 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.19764392585316587	[319]	[190,120,264]	2	hSpCas9	negative selection	2008990
13123988	13124011	10	+	26627737	HCT116	viability after 12 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	-0.6275507253430901	[341]	[93,158,98]	-6	hSpCas9	negative selection	2008991
13109200	13109223	10	-	26627737	HCT116	viability after 15 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	-0.15849783957530106	[267]	[78,228,98]	-2	hSpCas9	negative selection	2091298
13110310	13110333	10	+	26627737	HCT116	viability after 15 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	1.2811700590561026	[41]	[21,56,91]	8	hSpCas9	negative selection	2091299
13112518	13112541	10	-	26627737	HCT116	viability after 15 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.9005867401595892	[236]	[169,407,174]	7	hSpCas9	negative selection	2091300
13116315	13116338	10	+	26627737	HCT116	viability after 15 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	0.8523870511325842	[180]	[285,101,186]	7	hSpCas9	negative selection	2091304
13119008	13119031	10	+	26627737	HCT116	viability after 15 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.520911457011671	[319]	[248,169,368]	5	hSpCas9	negative selection	2091305
13123988	13124011	10	+	26627737	HCT116	viability after 15 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	-0.294306510932449	[341]	[204,124,155]	-3	hSpCas9	negative selection	2091306
13109200	13109223	10	-	26627737	HCT116	viability after 18 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	-0.2670280302440829	[267]	[123,83,116]	-2	hSpCas9	negative selection	2173613
13110310	13110333	10	+	26627737	HCT116	viability after 18 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.8533364437920492	[41]	[3,41,64]	6	hSpCas9	negative selection	2173614
13112518	13112541	10	-	26627737	HCT116	viability after 18 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.9245573262913014	[236]	[263,244,137]	7	hSpCas9	negative selection	2173615
13116315	13116338	10	+	26627737	HCT116	viability after 18 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	0.8426998396351355	[180]	[213,165,86]	6	hSpCas9	negative selection	2173619
13119008	13119031	10	+	26627737	HCT116	viability after 18 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-0.10526913146281822	[319]	[119,88,229]	-1	hSpCas9	negative selection	2173620
13123988	13124011	10	+	26627737	HCT116	viability after 18 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	-0.6188330541715289	[341]	[96,94,132]	-5	hSpCas9	negative selection	2173621
13109127	13109150	10	-	24336569	HL60	viability	GAGGCAGCTGAGAGGTTGATGGG	OPTN	ENSG00000123240	0.4082582082502013	[526]	[1479]	4	hSpCas9	negative selection	2282172
13109168	13109191	10	+	24336569	HL60	viability	CCCAGTGAAAGCACAGGAAATGG	OPTN	ENSG00000123240	1.5861495802702077	[211]	[1346]	9	hSpCas9	negative selection	2282173
13109196	13109219	10	-	24336569	HL60	viability	CAGGTTTGGGTGGGCCAGGTGGG	OPTN	ENSG00000123240	0.15292308298235524	[461]	[1086]	1	hSpCas9	negative selection	2282174
13109205	13109228	10	-	24336569	HL60	viability	AAACGTGTCCAGGTTTGGGTGGG	OPTN	ENSG00000123240	0.579733985919345	[429]	[1359]	5	hSpCas9	negative selection	2282175
13109230	13109253	10	-	24336569	HL60	viability	TCTGCTGCAGCAGCTCCTCCGGG	OPTN	ENSG00000123240	1.3582692266025915	[180]	[981]	8	hSpCas9	negative selection	2282176
13109263	13109286	10	-	24336569	HL60	viability	TCAGCTGGTGGTTCTCGGTCAGG	OPTN	ENSG00000123240	1.9247840470362814	[143]	[1156]	9	hSpCas9	negative selection	2282177
13109268	13109291	10	-	24336569	HL60	viability	ACCTTTCAGCTGGTGGTTCTCGG	OPTN	ENSG00000123240	0.8496159605466934	[551]	[2104]	7	hSpCas9	negative selection	2282178
13109275	13109298	10	-	24336569	HL60	viability	CCTGCTCACCTTTCAGCTGGTGG	OPTN	ENSG00000123240	0.7171312617870673	[235]	[820]	6	hSpCas9	negative selection	2282179
13110277	13110300	10	-	24336569	HL60	viability	GGCTTGATTATTTAGCTTCATGG	OPTN	ENSG00000123240	-0.2979250445576994	[444]	[765]	-3	hSpCas9	negative selection	2282180
13110285	13110308	10	+	24336569	HL60	viability	CTAAATAATCAAGCCATGAAAGG	OPTN	ENSG00000123240	0.13133270807442374	[430]	[998]	1	hSpCas9	negative selection	2282181
13109127	13109150	10	-	24336569	KBM7	viability	GAGGCAGCTGAGAGGTTGATGGG	OPTN	ENSG00000123240	-0.11169264407160057	[575]	[1453]	-1	hSpCas9	negative selection	2349349
13109168	13109191	10	+	24336569	KBM7	viability	CCCAGTGAAAGCACAGGAAATGG	OPTN	ENSG00000123240	0.6423533087126321	[205]	[876]	6	hSpCas9	negative selection	2349350
13109196	13109219	10	-	24336569	KBM7	viability	CAGGTTTGGGTGGGCCAGGTGGG	OPTN	ENSG00000123240	0.11238892470540401	[523]	[1544]	1	hSpCas9	negative selection	2349351
13109205	13109228	10	-	24336569	KBM7	viability	AAACGTGTCCAGGTTTGGGTGGG	OPTN	ENSG00000123240	0.7285162487565512	[336]	[1522]	6	hSpCas9	negative selection	2349352
13109230	13109253	10	-	24336569	KBM7	viability	TCTGCTGCAGCAGCTCCTCCGGG	OPTN	ENSG00000123240	0.24836660754149953	[370]	[1201]	2	hSpCas9	negative selection	2349353
13109263	13109286	10	-	24336569	KBM7	viability	TCAGCTGGTGGTTCTCGGTCAGG	OPTN	ENSG00000123240	-0.7306211500177362	[333]	[548]	-5	hSpCas9	negative selection	2349354
13109268	13109291	10	-	24336569	KBM7	viability	ACCTTTCAGCTGGTGGTTCTCGG	OPTN	ENSG00000123240	0.8033036508900279	[461]	[2198]	7	hSpCas9	negative selection	2349355
13109275	13109298	10	-	24336569	KBM7	viability	CCTGCTCACCTTTCAGCTGGTGG	OPTN	ENSG00000123240	0.6862765501859078	[215]	[947]	6	hSpCas9	negative selection	2349356
13110277	13110300	10	-	24336569	KBM7	viability	GGCTTGATTATTTAGCTTCATGG	OPTN	ENSG00000123240	1.3492875893591962	[354]	[2466]	9	hSpCas9	negative selection	2349357
13110285	13110308	10	+	24336569	KBM7	viability	CTAAATAATCAAGCCATGAAAGG	OPTN	ENSG00000123240	0.6258654449437618	[291]	[1228]	5	hSpCas9	negative selection	2349358
13134750	13134773	10	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGCGTTTCACCATGTTGGCCAGG	OPTN	ENSG00000123240	0.44435531486280433	[154,264]	[28,99]	2	dCas9-VP64	positive selection	2404966
13099913	13099936	10	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGCTGGGACCCGGGTGAACAGGG	OPTN	ENSG00000123240	0.7838919782282331	[67,82]	[50,4]	3	dCas9-VP64	positive selection	2422412
13099934	13099957	10	-	25494202	A375	resistance to PLX-4720 (puromycin)	TCGCTGTCCGTGCGGGGTCGAGG	OPTN	ENSG00000123240	0.49987360234834877	[26,37]	[2,16]	2	dCas9-VP64	positive selection	2422413
13099914	13099937	10	-	25494202	A375	resistance to PLX-4720 (puromycin)	AGGCTGGGACCCGGGTGAACAGG	OPTN	ENSG00000123240	0.0626964544293036	[31,43]	[10,5]	0	dCas9-VP64	positive selection	2454034
13099940	13099963	10	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCCCGCACGGACAGCGAGGGTGG	OPTN	ENSG00000123240	-1.2565981983055254	[53,30]	[4,1]	-7	dCas9-VP64	positive selection	2454035
13099887	13099910	10	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCTCTAAGGCGTCACTGTGACGG	OPTN	ENSG00000123240	0.16756007413506868	[258,330]	[70,74]	0	dCas9-VP64	positive selection	2454036
13136390	13136413	10	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCCAGCTACTCAGGAGGCCAAAG	OPTN	ENSG00000123240	2.2407410964735313	[125,48]	[159,15]	7	dCas9-VP64	positive selection	2477913
13134750	13134773	10	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGCGTTTCACCATGTTGGCCAGG	OPTN	ENSG00000123240	-0.3639755036387148	[260,201]	[38,76]	-4	dCas9-VP64	positive selection	2500221
13099913	13099936	10	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGCTGGGACCCGGGTGAACAGGG	OPTN	ENSG00000123240	0.7221032016727029	[78,68]	[54,24]	5	dCas9-VP64	positive selection	2517667
13099934	13099957	10	-	25494202	A375	resistance to PLX-4720 (zeocin)	TCGCTGTCCGTGCGGGGTCGAGG	OPTN	ENSG00000123240	-1.1955508720679398	[275,40]	[33,11]	-9	dCas9-VP64	positive selection	2517668
13099914	13099937	10	-	25494202	A375	resistance to PLX-4720 (zeocin)	AGGCTGGGACCCGGGTGAACAGG	OPTN	ENSG00000123240	-0.7210313025970174	[69,313]	[18,53]	-7	dCas9-VP64	positive selection	2549289
13099940	13099963	10	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCCCGCACGGACAGCGAGGGTGG	OPTN	ENSG00000123240	0.003045977273177014	[60,8]	[18,3]	0	dCas9-VP64	positive selection	2549290
13099887	13099910	10	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCTCTAAGGCGTCACTGTGACGG	OPTN	ENSG00000123240	1.1424137711753883	[268,238]	[68,290]	7	dCas9-VP64	positive selection	2549291
13136390	13136413	10	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCCAGCTACTCAGGAGGCCAAAG	OPTN	ENSG00000123240	-0.5858132620362408	[133,143]	[25,33]	-6	dCas9-VP64	positive selection	2573168
13110434	13110457	10	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AAGAGCTTGGAAAACTAAAAGGG	OPTN	ENSG00000123240	0.8377667847483894	[2,2]	[3,4]	9	hSpCas9	positive selection	3007468
13116263	13116286	10	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CACAGGAAGGAGAAGCAGAAGGG	OPTN	ENSG00000123240	0.13093062724211457	[4,4]	[4,4]	2	hSpCas9	positive selection	3007469
13122423	13122446	10	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GAGATTGAAACCCAGACAGAGGG	OPTN	ENSG00000123240	-0.49960524574361	[3,3]	[3,0]	-6	hSpCas9	positive selection	3007470
13112462	13112485	10	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGATGACTCCAGGCTTCCCAGGG	OPTN	ENSG00000123240	-0.0883638181381331	[5,5]	[5,2]	-1	hSpCas9	positive selection	3007471
13110434	13110457	10	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AAGAGCTTGGAAAACTAAAAGGG	OPTN	ENSG00000123240	-1.0717227001704592	[2,2]	[0,0]	-9	hSpCas9	positive selection	3075326
13116263	13116286	10	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CACAGGAAGGAGAAGCAGAAGGG	OPTN	ENSG00000123240	-0.11482744189915978	[4,4]	[3,2]	-2	hSpCas9	positive selection	3075327
13122423	13122446	10	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GAGATTGAAACCCAGACAGAGGG	OPTN	ENSG00000123240	-0.603679143929167	[3,3]	[2,0]	-8	hSpCas9	positive selection	3075328
13112462	13112485	10	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGATGACTCCAGGCTTCCCAGGG	OPTN	ENSG00000123240	0.32154407073942287	[5,5]	[4,4]	5	hSpCas9	positive selection	3075329
13125948	13125971		-	24336571	A375	resistance to PLX after 7 days	CATCTGTAGCACAGTTAATTTGG	OPTN	ENSG00000123240	0.09975529548685207	[10,14]	[13,12]	3	hSpCas9	positive selection	3132522
13112518	13112541		-	24336571	A375	resistance to PLX after 7 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.062395683737633045	[19,21]	[21,20]	2	hSpCas9	positive selection	3132523
13112551	13112574		-	24336571	A375	resistance to PLX after 7 days	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	-0.09201070722215246	[17,14]	[15,13]	-3	hSpCas9	positive selection	3132524
13125948	13125971		-	24336571	A375	resistance to PLX after 14 days	CATCTGTAGCACAGTTAATTTGG	OPTN	ENSG00000123240	0.1429873091449824	[15,12]	[6,6]	1	hSpCas9	positive selection	3190315
13112518	13112541		-	24336571	A375	resistance to PLX after 14 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	-0.6359744721509655	[26,15]	[3,7]	-7	hSpCas9	positive selection	3190316
13112551	13112574		-	24336571	A375	resistance to PLX after 14 days	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.12237871873156703	[13,15]	[6,7]	1	hSpCas9	positive selection	3190317
13125948	13125971		-	24336571	A375	viability after 7 days	CATCTGTAGCACAGTTAATTTGG	OPTN	ENSG00000123240	0.041099187774270705	[12]	[10,14]	0	hSpCas9	negative selection	3248108
13112518	13112541		-	24336571	A375	viability after 7 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.6441573210552033	[13]	[19,21]	8	hSpCas9	negative selection	3248109
13112551	13112574		-	24336571	A375	viability after 7 days	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.316971855301513	[13]	[17,14]	5	hSpCas9	negative selection	3248110
13125948	13125971		-	24336571	A375	viability after 14 days	CATCTGTAGCACAGTTAATTTGG	OPTN	ENSG00000123240	0.22507445907417212	[12]	[15,12]	3	hSpCas9	negative selection	3305901
13112518	13112541		-	24336571	A375	viability after 14 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.6786695292841186	[13]	[26,15]	8	hSpCas9	negative selection	3305902
13112551	13112574		-	24336571	A375	viability after 14 days	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.22856350781321394	[13]	[13,15]	3	hSpCas9	negative selection	3305903
13116316	13116339	10	-	27383988	293T	resistance to West Nile virus (flavivirus)	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	0.16986337019549572	[135,135]	[0,0]	0	hSpCas9	positive selection	3383074
13112476	13112499	10	+	27383988	293T	resistance to West Nile virus (flavivirus)	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	4.087401210003523	[8,8]	[0,0]	9	hSpCas9	positive selection	3383075
13112551	13112574	10	-	27383988	293T	resistance to West Nile virus (flavivirus)	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	-1.0464545367312679	[315,315]	[0,0]	-7	hSpCas9	positive selection	3383076
13110433	13110456	10	+	26780180	HT29	viability (Avana library 4 designs)	AAGAGCTTGGAAAACTAAAAGGG	OPTN	ENSG00000123240	0.722003241233695	[]	[]	2	hSpCas9	negative selection	3445402
13116262	13116285	10	+	26780180	HT29	viability (Avana library 4 designs)	CACAGGAAGGAGAAGCAGAAGGG	OPTN	ENSG00000123240	0.281479387409775	[]	[]	1	hSpCas9	negative selection	3445403
13122422	13122445	10	+	26780180	HT29	viability (Avana library 4 designs)	GAGATTGAAACCCAGACAGAGGG	OPTN	ENSG00000123240	1.07851568196076	[]	[]	4	hSpCas9	negative selection	3445404
13112461	13112484	10	+	26780180	HT29	viability (Avana library 4 designs)	TGATGACTCCAGGCTTCCCAGGG	OPTN	ENSG00000123240	-0.0973947768183577	[]	[]	-1	hSpCas9	negative selection	3445405
13112461	13112484	10	+	26780180	A375	viability (Avana lentiCRISPRv2)	TGATGACTCCAGGCTTCCCAGGG	OPTN	ENSG00000123240	1.76665553464972	[]	[]	2	hSpCas9	negative selection	3538115
13116262	13116285	10	+	26780180	A375	viability (Avana lentiCRISPRv2)	CACAGGAAGGAGAAGCAGAAGGG	OPTN	ENSG00000123240	0.0233750614153772	[]	[]	0	hSpCas9	negative selection	3538116
13110433	13110456	10	+	26780180	A375	viability (Avana lentiCRISPRv2)	AAGAGCTTGGAAAACTAAAAGGG	OPTN	ENSG00000123240	-13.0250418357742	[]	[]	-8	hSpCas9	negative selection	3538117
13122422	13122445	10	+	26780180	A375	viability (Avana lentiCRISPRv2)	GAGATTGAAACCCAGACAGAGGG	OPTN	ENSG00000123240	-8.27567548646536	[]	[]	-7	hSpCas9	negative selection	3538118
13118902	13118925	10	+	26780180	A375	viability (Avana lentiCRISPRv2)	ATAGGAGCAGATCTGCAGATGGG	OPTN	ENSG00000123240	3.07713369077502	[]	[]	5	hSpCas9	negative selection	3538119
13112503	13112526	10	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-2.23079139241913	[]	[]	-3	hSpCas9	negative selection	3538120
13112461	13112484	10	+	26780180	A375	viability (Avana lentiGuide)	TGATGACTCCAGGCTTCCCAGGG	OPTN	ENSG00000123240	-3.69263341873598	[]	[]	-6	hSpCas9	negative selection	3646774
13116262	13116285	10	+	26780180	A375	viability (Avana lentiGuide)	CACAGGAAGGAGAAGCAGAAGGG	OPTN	ENSG00000123240	-7.29217619887614	[]	[]	-9	hSpCas9	negative selection	3646775
13110433	13110456	10	+	26780180	A375	viability (Avana lentiGuide)	AAGAGCTTGGAAAACTAAAAGGG	OPTN	ENSG00000123240	-5.99758217037959	[]	[]	-8	hSpCas9	negative selection	3646776
13122422	13122445	10	+	26780180	A375	viability (Avana lentiGuide)	GAGATTGAAACCCAGACAGAGGG	OPTN	ENSG00000123240	8.98180367655255	[]	[]	6	hSpCas9	negative selection	3646777
13118902	13118925	10	+	26780180	A375	viability (Avana lentiGuide)	ATAGGAGCAGATCTGCAGATGGG	OPTN	ENSG00000123240	-5.07674148622582	[]	[]	-8	hSpCas9	negative selection	3646778
13112503	13112526	10	+	26780180	A375	viability (Avana lentiGuide)	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	14.3382416473881	[]	[]	8	hSpCas9	negative selection	3646779
13112461	13112484	10	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGATGACTCCAGGCTTCCCAGGG	OPTN	ENSG00000123240	-0.14114004084484885	[6]	[6,4]	-2	hSpCas9	positive selection	3755433
13116262	13116285	10	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CACAGGAAGGAGAAGCAGAAGGG	OPTN	ENSG00000123240	0.016597976592256036	[5]	[6,4]	0	hSpCas9	positive selection	3755434
13110433	13110456	10	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AAGAGCTTGGAAAACTAAAAGGG	OPTN	ENSG00000123240	-1.0626269888587898	[5]	[2,1]	-9	hSpCas9	positive selection	3755435
13122422	13122445	10	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GAGATTGAAACCCAGACAGAGGG	OPTN	ENSG00000123240	-0.14788120164414265	[4]	[4,3]	-2	hSpCas9	positive selection	3755436
13118902	13118925	10	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATAGGAGCAGATCTGCAGATGGG	OPTN	ENSG00000123240	0.042962372526185344	[5]	[5,4]	1	hSpCas9	positive selection	3755437
13112503	13112526	10	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-0.30686998687360084	[4]	[3,2]	-5	hSpCas9	positive selection	3755438
13112461	13112484	10	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGATGACTCCAGGCTTCCCAGGG	OPTN	ENSG00000123240	0.20380019341448974	[7]	[6,7]	5	hSpCas9	positive selection	3864040
13116262	13116285	10	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CACAGGAAGGAGAAGCAGAAGGG	OPTN	ENSG00000123240	0.2231442166515506	[6]	[6,5]	6	hSpCas9	positive selection	3864041
13110433	13110456	10	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AAGAGCTTGGAAAACTAAAAGGG	OPTN	ENSG00000123240	0.7801157678672527	[3]	[6,4]	9	hSpCas9	positive selection	3864042
13122422	13122445	10	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GAGATTGAAACCCAGACAGAGGG	OPTN	ENSG00000123240	-0.010733163852568978	[4]	[2,4]	0	hSpCas9	positive selection	3864043
13118902	13118925	10	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATAGGAGCAGATCTGCAGATGGG	OPTN	ENSG00000123240	0.10835367549478445	[4]	[3,4]	2	hSpCas9	positive selection	3864044
13112503	13112526	10	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-0.6594850203751464	[4]	[2,0]	-7	hSpCas9	positive selection	3864045
13110380	13110403	10	+	26780180	A375	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	1.29998213413488	[]	[]	7	hSpCas9	negative selection	3975180
13116315	13116338	10	+	26780180	A375	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	1.48292064057106	[]	[]	8	hSpCas9	negative selection	3975181
13110310	13110333	10	+	26780180	A375	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.520080104974205	[]	[]	1	hSpCas9	negative selection	3975182
13116316	13116339	10	-	26780180	A375	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	0.523779080343034	[]	[]	1	hSpCas9	negative selection	3975183
13112551	13112574	10	-	26780180	A375	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	1.12491289618476	[]	[]	5	hSpCas9	negative selection	3975184
13112476	13112499	10	+	26780180	A375	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.175486391513809	[]	[]	0	hSpCas9	negative selection	3975185
13110380	13110403	10	+	26780180	HT29	viability (GeCKOv2 library)	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	0.276520950757116	[]	[]	0	hSpCas9	negative selection	4083146
13116315	13116338	10	+	26780180	HT29	viability (GeCKOv2 library)	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	1.2585395787076	[]	[]	6	hSpCas9	negative selection	4083147
13110310	13110333	10	+	26780180	HT29	viability (GeCKOv2 library)	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	1.05509159174295	[]	[]	5	hSpCas9	negative selection	4083148
13116316	13116339	10	-	26780180	HT29	viability (GeCKOv2 library)	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	1.37739554672215	[]	[]	7	hSpCas9	negative selection	4083149
13112551	13112574	10	-	26780180	HT29	viability (GeCKOv2 library)	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	1.01606481086479	[]	[]	4	hSpCas9	negative selection	4083150
13112476	13112499	10	+	26780180	HT29	viability (GeCKOv2 library)	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.273358628003857	[]	[]	0	hSpCas9	negative selection	4083151
13125948	13125971	10	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CATCTGTAGCACAGTTAATTTGG	OPTN	ENSG00000123240	0.14435218445478734	[3]	[2,2]	3	hSpCas9	positive selection	4157315
13112518	13112541	10	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.7030980006082609	[4]	[8,2]	9	hSpCas9	positive selection	4157316
13112551	13112574	10	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.4230278799933747	[3]	[3,2]	8	hSpCas9	positive selection	4157317
13125948	13125971	10	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CATCTGTAGCACAGTTAATTTGG	OPTN	ENSG00000123240	1.1251040027491015	[4]	[3,3,1,4]	8	hSpCas9	positive selection	4221337
13112518	13112541	10	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	1.1953739753825539	[4]	[4,4,0,5]	8	hSpCas9	positive selection	4221338
13112551	13112574	10	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	1.0140012161258778	[3]	[4,0,2,3]	7	hSpCas9	positive selection	4221339
13110310	13110333	10	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.03253929532981349	[2]	[2,1]	0	hSpCas9	positive selection	4287111
13116315	13116338	10	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	0.25488225624427147	[2]	[2,2]	5	hSpCas9	positive selection	4287112
13110380	13110403	10	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.079093429097708	[2]	[2,0]	-1	hSpCas9	positive selection	4287113
13116316	13116339	10	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.7139130088194522	[2]	[1,0]	-9	hSpCas9	positive selection	4351366
13112476	13112499	10	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.11337786242534342	[0]	[0,0]	2	hSpCas9	positive selection	4351367
13112551	13112574	10	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.44490414509210335	[3]	[3,4]	8	hSpCas9	positive selection	4351368
13109213	13109235	10	+	27760321	OCIAML3	viability	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	0.2797871473985943	[523,380]	[365,502]	3	hSpCas9	negative selection	4424695
13112551	13112573	10	-	27760321	OCIAML3	viability	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.24190852991337752	[546,371]	[328,537]	3	hSpCas9	negative selection	4424696
13112592	13112614	10	-	27760321	OCIAML3	viability	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	0.5391931864773019	[897,847]	[772,1279]	6	hSpCas9	negative selection	4424697
13118928	13118950	10	+	27760321	OCIAML3	viability	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	0.3147216383477647	[197,155]	[210,118]	3	hSpCas9	negative selection	4424698
13119009	13119031	10	+	27760321	OCIAML3	viability	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	1.2473809764159935	[330,275]	[456,696]	9	hSpCas9	negative selection	4424699
13109213	13109235	10	+	27760321	OCIAML2	viability	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	0.02360381122359792	[523,380]	[317,434]	0	hSpCas9	negative selection	4508158
13112551	13112573	10	-	27760321	OCIAML2	viability	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.2955667173350854	[546,371]	[362,565]	4	hSpCas9	negative selection	4508159
13112592	13112614	10	-	27760321	OCIAML2	viability	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	0.8213772824102381	[897,847]	[1063,1492]	9	hSpCas9	negative selection	4508160
13118928	13118950	10	+	27760321	OCIAML2	viability	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	0.10439285516426589	[197,155]	[161,140]	1	hSpCas9	negative selection	4508161
13119009	13119031	10	+	27760321	OCIAML2	viability	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-0.5217336336011464	[330,275]	[146,200]	-5	hSpCas9	negative selection	4508162
13109213	13109235	10	+	27760321	MV411	viability	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	1.1326870920575092	[523,380]	[647,648]	8	hSpCas9	negative selection	4591621
13112551	13112573	10	-	27760321	MV411	viability	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.10334989584612611	[546,371]	[226,463]	0	hSpCas9	negative selection	4591622
13112592	13112614	10	-	27760321	MV411	viability	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	0.5460945848371559	[897,847]	[787,922]	4	hSpCas9	negative selection	4591623
13118928	13118950	10	+	27760321	MV411	viability	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	-1.9055458728208674	[197,155]	[0,75]	-8	hSpCas9	negative selection	4591624
13119009	13119031	10	+	27760321	MV411	viability	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.5154359975690612	[330,275]	[400,110]	3	hSpCas9	negative selection	4591625
13109213	13109235	10	+	27760321	HL60	viability	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	-0.7352215634795277	[523,380]	[199,240]	-6	hSpCas9	negative selection	4675084
13112551	13112573	10	-	27760321	HL60	viability	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	1.4821595833849515	[546,371]	[974,1099]	9	hSpCas9	negative selection	4675085
13112592	13112614	10	-	27760321	HL60	viability	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	-0.019086473521395586	[897,847]	[651,759]	0	hSpCas9	negative selection	4675086
13118928	13118950	10	+	27760321	HL60	viability	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	0.1217699689566265	[197,155]	[182,127]	1	hSpCas9	negative selection	4675087
13119009	13119031	10	+	27760321	HL60	viability	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.7371195435307717	[330,275]	[395,427]	8	hSpCas9	negative selection	4675088
13109213	13109235	10	+	27760321	HT1080	viability	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	0.7593405358479292	[380,297]	[301,148]	4	hSpCas9	negative selection	4758547
13112551	13112573	10	-	27760321	HT1080	viability	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	1.0747619303463412	[371,289]	[271,283]	6	hSpCas9	negative selection	4758548
13112592	13112614	10	-	27760321	HT1080	viability	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	0.3357025352916032	[847,661]	[338,423]	1	hSpCas9	negative selection	4758549
13118928	13118950	10	+	27760321	HT1080	viability	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	-0.7094718335206069	[155,121]	[9,59]	-3	hSpCas9	negative selection	4758550
13119009	13119031	10	+	27760321	HT1080	viability	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	1.0168492349121667	[275,215]	[236,155]	5	hSpCas9	negative selection	4758551
13109213	13109235	10	+	27760321	HT29	viability after 7 days	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	0.3678925643662585	[380,297]	[845,460,426]	5	hSpCas9	negative selection	4842010
13112551	13112573	10	-	27760321	HT29	viability after 7 days	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	-0.148620911030774	[371,289]	[345,488,312]	-2	hSpCas9	negative selection	4842011
13112592	13112614	10	-	27760321	HT29	viability after 7 days	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	0.19548315363738555	[847,661]	[1386,1082,908]	3	hSpCas9	negative selection	4842012
13118928	13118950	10	+	27760321	HT29	viability after 7 days	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	-0.6217109927461919	[155,121]	[107,149,89]	-7	hSpCas9	negative selection	4842013
13119009	13119031	10	+	27760321	HT29	viability after 7 days	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.2916726124282782	[275,215]	[537,333,312]	4	hSpCas9	negative selection	4842014
13109213	13109235	10	+	27760321	HT29	viability after 25 days	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	0.5370902726712375	[380,297]	[543,319,855]	6	hSpCas9	negative selection	4925473
13112551	13112573	10	-	27760321	HT29	viability after 25 days	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.6652862375009959	[371,289]	[570,650,575]	7	hSpCas9	negative selection	4925474
13112592	13112614	10	-	27760321	HT29	viability after 25 days	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	0.12539981617227647	[847,661]	[687,1097,1064]	1	hSpCas9	negative selection	4925475
13118928	13118950	10	+	27760321	HT29	viability after 25 days	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	-1.2525668635539224	[155,121]	[13,141,44]	-7	hSpCas9	negative selection	4925476
13119009	13119031	10	+	27760321	HT29	viability after 25 days	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-0.03316001598127849	[275,215]	[309,251,257]	0	hSpCas9	negative selection	4925477
13109213	13109235	10	+	27760321	HT29	viability after 22 days	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	0.5956043567757029	[380,297]	[668,451,656]	6	hSpCas9	negative selection	5008936
13112551	13112573	10	-	27760321	HT29	viability after 22 days	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.823560276518931	[371,289]	[855,661,506]	8	hSpCas9	negative selection	5008937
13112592	13112614	10	-	27760321	HT29	viability after 22 days	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	-0.06354865250524266	[847,661]	[834,900,768]	0	hSpCas9	negative selection	5008938
13118928	13118950	10	+	27760321	HT29	viability after 22 days	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	-0.44075382177193223	[155,121]	[46,205,103]	-4	hSpCas9	negative selection	5008939
13119009	13119031	10	+	27760321	HT29	viability after 22 days	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.21580197020903052	[275,215]	[321,359,308]	2	hSpCas9	negative selection	5008940
13109213	13109235	10	+	27760321	HT29	viability after 19 days	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	0.5074827406586191	[380,297]	[653,636,381]	5	hSpCas9	negative selection	5092399
13112551	13112573	10	-	27760321	HT29	viability after 19 days	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.8337208226393876	[371,289]	[721,646,659]	8	hSpCas9	negative selection	5092400
13112592	13112614	10	-	27760321	HT29	viability after 19 days	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	0.025201889190759275	[847,661]	[776,918,926]	0	hSpCas9	negative selection	5092401
13118928	13118950	10	+	27760321	HT29	viability after 19 days	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	-0.7478864423984892	[155,121]	[19,237,20]	-5	hSpCas9	negative selection	5092402
13119009	13119031	10	+	27760321	HT29	viability after 19 days	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.4705311179883889	[275,215]	[441,318,412]	4	hSpCas9	negative selection	5092403
13109213	13109235	10	+	27760321	HT29	viability after 16 days	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	0.3952091413988609	[380,297]	[633,323,557]	4	hSpCas9	negative selection	5175862
13112551	13112573	10	-	27760321	HT29	viability after 16 days	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.44735130476265894	[371,289]	[445,431,632]	5	hSpCas9	negative selection	5175863
13112592	13112614	10	-	27760321	HT29	viability after 16 days	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	0.11584128396644489	[847,661]	[1254,759,766]	1	hSpCas9	negative selection	5175864
13118928	13118950	10	+	27760321	HT29	viability after 16 days	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	-0.593609191926993	[155,121]	[121,63,125]	-5	hSpCas9	negative selection	5175865
13119009	13119031	10	+	27760321	HT29	viability after 16 days	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.2631777447715183	[275,215]	[175,423,373]	3	hSpCas9	negative selection	5175866
13109213	13109235	10	+	27760321	HT29	viability after 13 days	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	0.687872962230676	[380,297]	[500,787,615]	8	hSpCas9	negative selection	5259325
13112551	13112573	10	-	27760321	HT29	viability after 13 days	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	1.0816916409074204	[371,289]	[1052,787,608]	9	hSpCas9	negative selection	5259326
13112592	13112614	10	-	27760321	HT29	viability after 13 days	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	0.12372842778977033	[847,661]	[772,1114,973]	1	hSpCas9	negative selection	5259327
13118928	13118950	10	+	27760321	HT29	viability after 13 days	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	-0.4905862723938905	[155,121]	[92,112,136]	-5	hSpCas9	negative selection	5259328
13119009	13119031	10	+	27760321	HT29	viability after 13 days	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.3314551209220875	[275,215]	[418,447,218]	4	hSpCas9	negative selection	5259329
13109213	13109235	10	+	27760321	HT29	viability after 10 days	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	0.2889124075553814	[380,297]	[643,446,461]	4	hSpCas9	negative selection	5342788
13112551	13112573	10	-	27760321	HT29	viability after 10 days	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.6592583616489432	[371,289]	[750,853,364]	8	hSpCas9	negative selection	5342789
13112592	13112614	10	-	27760321	HT29	viability after 10 days	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	0.18416544926329248	[847,661]	[1263,725,1209]	2	hSpCas9	negative selection	5342790
13118928	13118950	10	+	27760321	HT29	viability after 10 days	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	-0.3142856949011361	[155,121]	[119,72,221]	-4	hSpCas9	negative selection	5342791
13119009	13119031	10	+	27760321	HT29	viability after 10 days	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.16400293336091393	[275,215]	[410,504,125]	2	hSpCas9	negative selection	5342792
13109213	13109235	10	+	27760321	MOLM13	viability	AACCTGGACACGTTTACCCCGG	OPTN	ENSG00000123240	-0.19453883615328899	[523,380]	[315,139]	-1	hSpCas9	negative selection	5426251
13112551	13112573	10	-	27760321	MOLM13	viability	TTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	-0.38286396276764245	[546,371]	[177,211]	-3	hSpCas9	negative selection	5426252
13112592	13112614	10	-	27760321	MOLM13	viability	GAATCTTCTGAGGAGCCGCTGG	OPTN	ENSG00000123240	0.012119977273884697	[897,847]	[763,269]	0	hSpCas9	negative selection	5426253
13118928	13118950	10	+	27760321	MOLM13	viability	AAGAATTACTTCGAACATGAGG	OPTN	ENSG00000123240	-0.8150683496818198	[197,155]	[77,37]	-5	hSpCas9	negative selection	5426254
13119009	13119031	10	+	27760321	MOLM13	viability	CTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-0.33478792461542384	[330,275]	[44,211]	-2	hSpCas9	negative selection	5426255
13100230	13100253	10	+	27661255	K562	viability	GGTCGGGAGTTCTCTCCAGGCGG	OPTN	ENSG00000123240	-0.18589388654484867	[838,902]	[646,579]	-5	dCas9-KRAB	negative selection	5498503
13100675	13100698	10	+	27661255	K562	viability	GACACGCCTGTGGGAGACATGGG	OPTN	ENSG00000123240	-0.09342133780673734	[1136,1208]	[812,931]	-3	dCas9-KRAB	negative selection	5498504
13099788	13099811	10	-	27661255	K562	viability	GTGGAGGCTGGAGCCGCAGGGGG	OPTN	ENSG00000123240	-2.1288926784310678	[801,910]	[215,104]	-9	dCas9-KRAB	negative selection	5498505
13100223	13100246	10	-	27661255	K562	viability	GAGAGAACTCCCGACCGGGATGG	OPTN	ENSG00000123240	-1.3644307730268417	[430,475]	[174,110]	-9	dCas9-KRAB	negative selection	5498506
13100539	13100562	10	-	27661255	K562	viability	GCCGGCCCTGGACCCTTCTTGGG	OPTN	ENSG00000123240	0.09819628368972921	[314,319]	[292,252]	3	dCas9-KRAB	negative selection	5498507
13110310	13110333	10	+	27260156	BXPC3	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.550820672791034	[368]	[565,532,578,582]	9	hSpCas9	negative selection	5559571
13116315	13116338	10	+	27260156	BXPC3	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.0838475593083246	[349]	[383,358,312,312]	-2	hSpCas9	negative selection	5559572
13110380	13110403	10	+	27260156	BXPC3	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.3036706530357218	[219]	[122,189,211,231]	-6	hSpCas9	negative selection	5559573
13116316	13116339	10	-	27260156	BXPC3	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.1432264287301191	[362]	[282,331,306,472]	-3	hSpCas9	negative selection	5623826
13112476	13112499	10	+	27260156	BXPC3	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.5086073376638125	[11]	[38,45,22,32]	9	hSpCas9	negative selection	5623827
13112551	13112574	10	-	27260156	BXPC3	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.02041902713012822	[685]	[780,622,806,690]	0	hSpCas9	negative selection	5623828
13110310	13110333	10	+	27260156	A673	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.5684867602934951	[368]	[619,657,589,760]	9	hSpCas9	negative selection	5680822
13116315	13116338	10	+	27260156	A673	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.24303743477603296	[349]	[364,420,304,326]	-5	hSpCas9	negative selection	5680823
13110380	13110403	10	+	27260156	A673	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.12365121431260495	[219]	[246,234,260,225]	-3	hSpCas9	negative selection	5680824
13116316	13116339	10	-	27260156	A673	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	0.028548497103121573	[362]	[481,486,313,501]	0	hSpCas9	negative selection	5745077
13112476	13112499	10	+	27260156	A673	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.100740469193588	[11]	[30,42,8,40]	9	hSpCas9	negative selection	5745078
13112551	13112574	10	-	27260156	A673	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.09684872125421373	[685]	[955,935,671,971]	2	hSpCas9	negative selection	5745079
13110310	13110333	10	+	27260156	A375	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.54680177337735	[368]	[499,877,619,559]	7	hSpCas9	negative selection	5802073
13116315	13116338	10	+	27260156	A375	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.3232800575067292	[349]	[314,276,336,364]	-4	hSpCas9	negative selection	5802074
13110380	13110403	10	+	27260156	A375	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	0.5758391370732481	[219]	[368,461,415,303]	8	hSpCas9	negative selection	5802075
13116316	13116339	10	-	27260156	A375	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.13390572957113606	[362]	[240,366,468,454]	-2	hSpCas9	negative selection	5866328
13112476	13112499	10	+	27260156	A375	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.5896885283853566	[11]	[5,66,18,0]	8	hSpCas9	negative selection	5866329
13112551	13112574	10	-	27260156	A375	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.11993564089479325	[685]	[953,1132,766,684]	1	hSpCas9	negative selection	5866330
13110310	13110333	10	+	27260156	COLO741	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.4470566749615257	[368]	[563,681,671]	8	hSpCas9	negative selection	5923324
13116315	13116338	10	+	27260156	COLO741	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.43217320906694096	[349]	[282,422,286]	-7	hSpCas9	negative selection	5923325
13110380	13110403	10	+	27260156	COLO741	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.024578503722561207	[219]	[357,281,200]	0	hSpCas9	negative selection	5923326
13116316	13116339	10	-	27260156	COLO741	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.298137129190388	[362]	[358,388,380]	-6	hSpCas9	negative selection	5987579
13112476	13112499	10	+	27260156	COLO741	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.0711727245964155	[11]	[26,20,46]	9	hSpCas9	negative selection	5987580
13112551	13112574	10	-	27260156	COLO741	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.18948594086671378	[685]	[824,1074,1075]	4	hSpCas9	negative selection	5987581
13110310	13110333	10	+	27260156	CAL120	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.3683361922416528	[368]	[484,529,743]	5	hSpCas9	negative selection	6044575
13116315	13116338	10	+	27260156	CAL120	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.4977414308447729	[349]	[310,215,396]	-6	hSpCas9	negative selection	6044576
13110380	13110403	10	+	27260156	CAL120	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.1786325067344452	[219]	[223,264,233]	-3	hSpCas9	negative selection	6044577
13116316	13116339	10	-	27260156	CAL120	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.1302949872865347	[362]	[662,333,280]	-2	hSpCas9	negative selection	6108830
13112476	13112499	10	+	27260156	CAL120	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.3749139948319202	[11]	[0,16,36]	5	hSpCas9	negative selection	6108831
13112551	13112574	10	-	27260156	CAL120	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.08133902993378661	[685]	[1045,747,935]	1	hSpCas9	negative selection	6108832
13110310	13110333	10	+	27260156	CADOES1	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.8035386042221857	[368]	[556,468,739,630]	9	hSpCas9	negative selection	6165826
13116315	13116338	10	+	27260156	CADOES1	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.525640406286819	[349]	[187,287,220,206]	-7	hSpCas9	negative selection	6165827
13110380	13110403	10	+	27260156	CADOES1	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.11656469743349396	[219]	[110,144,182,320]	-2	hSpCas9	negative selection	6165828
13116316	13116339	10	-	27260156	CADOES1	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	0.1716418083231288	[362]	[185,433,511,389]	3	hSpCas9	negative selection	6230081
13112476	13112499	10	+	27260156	CADOES1	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.0976924487619275	[11]	[9,51,25,6]	9	hSpCas9	negative selection	6230082
13112551	13112574	10	-	27260156	CADOES1	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	-0.30156856708589797	[685]	[609,498,479,479]	-5	hSpCas9	negative selection	6230083
13110310	13110333	10	+	27260156	EWS502	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.6613618752558671	[368]	[462,552,876,600]	9	hSpCas9	negative selection	6287077
13116315	13116338	10	+	27260156	EWS502	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.07870568810995299	[349]	[252,349,449,363]	-1	hSpCas9	negative selection	6287078
13110380	13110403	10	+	27260156	EWS502	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	0.17458976187449438	[219]	[250,397,182,209]	3	hSpCas9	negative selection	6287079
13116316	13116339	10	-	27260156	EWS502	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	0.10396358365050556	[362]	[356,370,443,493]	1	hSpCas9	negative selection	6351332
13112476	13112499	10	+	27260156	EWS502	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.1649941172513731	[11]	[32,17,31,30]	9	hSpCas9	negative selection	6351333
13112551	13112574	10	-	27260156	EWS502	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.19549493202572743	[685]	[748,794,886,911]	3	hSpCas9	negative selection	6351334
13110310	13110333	10	+	27260156	EW8	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.4553413022843968	[368]	[452,486,357,354]	7	hSpCas9	negative selection	6408328
13116315	13116338	10	+	27260156	EW8	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.328543769415004	[349]	[275,183,214,234]	-6	hSpCas9	negative selection	6408329
13110380	13110403	10	+	27260156	EW8	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	0.241069342702666	[219]	[235,159,160,295]	4	hSpCas9	negative selection	6408330
13116316	13116339	10	-	27260156	EW8	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	0.34587551673565353	[362]	[297,307,345,537]	6	hSpCas9	negative selection	6472583
13112476	13112499	10	+	27260156	EW8	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.20616100935707404	[11]	[18,20,3,2]	4	hSpCas9	negative selection	6472584
13112551	13112574	10	-	27260156	EW8	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.06739172934945736	[685]	[680,587,549,525]	1	hSpCas9	negative selection	6472585
13110310	13110333	10	+	27260156	CORL105	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.30636213650880334	[368]	[515,619,480,508]	6	hSpCas9	negative selection	6529579
13116315	13116338	10	+	27260156	CORL105	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.28722038359080887	[349]	[279,380,334,343]	-5	hSpCas9	negative selection	6529580
13110380	13110403	10	+	27260156	CORL105	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.21870020449079486	[219]	[251,188,196,244]	-4	hSpCas9	negative selection	6529581
13116316	13116339	10	-	27260156	CORL105	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.15914367600801776	[362]	[412,286,443,390]	-3	hSpCas9	negative selection	6593834
13112476	13112499	10	+	27260156	CORL105	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.4799024958325684	[11]	[7,34,47,65]	9	hSpCas9	negative selection	6593835
13112551	13112574	10	-	27260156	CORL105	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.057996762535977076	[685]	[748,785,971,855]	1	hSpCas9	negative selection	6593836
13110310	13110333	10	+	27260156	HS294T	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-0.28058856765329554	[368]	[129,101,92,148]	-4	hSpCas9	negative selection	6650830
13116315	13116338	10	+	27260156	HS294T	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.16502315061680167	[349]	[85,110,103,197]	-2	hSpCas9	negative selection	6650831
13110380	13110403	10	+	27260156	HS294T	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.7301431062190371	[219]	[48,49,60,43]	-8	hSpCas9	negative selection	6650832
13116316	13116339	10	-	27260156	HS294T	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.16146061061396616	[362]	[84,69,228,122]	-2	hSpCas9	negative selection	6715085
13112476	13112499	10	+	27260156	HS294T	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.4412016821125109	[11]	[3,1,10,8]	6	hSpCas9	negative selection	6715086
13112551	13112574	10	-	27260156	HS294T	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.12322398316719596	[685]	[245,200,229,523]	1	hSpCas9	negative selection	6715087
13110310	13110333	10	+	27260156	HCC44	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.1443209014284964	[368]	[513,302,679,410]	2	hSpCas9	negative selection	6772081
13116315	13116338	10	+	27260156	HCC44	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.44228649509867507	[349]	[255,345,406,166]	-6	hSpCas9	negative selection	6772082
13110380	13110403	10	+	27260156	HCC44	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	0.1500403670296172	[219]	[280,335,253,220]	2	hSpCas9	negative selection	6772083
13116316	13116339	10	-	27260156	HCC44	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.10205589694688777	[362]	[407,219,290,609]	-2	hSpCas9	negative selection	6836336
13112476	13112499	10	+	27260156	HCC44	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	-0.3148797433884347	[11]	[10,4,24,5]	-5	hSpCas9	negative selection	6836337
13112551	13112574	10	-	27260156	HCC44	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.02165041569607873	[685]	[885,492,1067,795]	0	hSpCas9	negative selection	6836338
13110310	13110333	10	+	27260156	G402	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.9643165043589887	[368]	[958,1145,473,954]	9	hSpCas9	negative selection	6893332
13116315	13116338	10	+	27260156	G402	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.4185707794907752	[349]	[507,233,256,300]	-5	hSpCas9	negative selection	6893333
13110380	13110403	10	+	27260156	G402	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.01687346849435234	[219]	[76,252,577,130]	0	hSpCas9	negative selection	6893334
13116316	13116339	10	-	27260156	G402	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.00623255964736108	[362]	[598,545,304,345]	0	hSpCas9	negative selection	6957587
13112476	13112499	10	+	27260156	G402	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.5658259916450881	[11]	[0,49,27,6]	7	hSpCas9	negative selection	6957588
13112551	13112574	10	-	27260156	G402	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.18608956145363043	[685]	[965,1073,746,1023]	2	hSpCas9	negative selection	6957589
13110310	13110333	10	+	27260156	L33	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.32453181419435845	[368]	[419,206,285,468]	7	hSpCas9	negative selection	7014583
13116315	13116338	10	+	27260156	L33	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.4085863251269865	[349]	[225,123,156,276]	-7	hSpCas9	negative selection	7014584
13110380	13110403	10	+	27260156	L33	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.4659428452700498	[219]	[151,53,129,146]	-8	hSpCas9	negative selection	7014585
13116316	13116339	10	-	27260156	L33	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.042844624317911084	[362]	[356,153,266,252]	-1	hSpCas9	negative selection	7078838
13112476	13112499	10	+	27260156	L33	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.09842577707113165	[11]	[13,4,6,13]	2	hSpCas9	negative selection	7078839
13112551	13112574	10	-	27260156	L33	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	-0.052155356501510874	[685]	[618,298,345,746]	-1	hSpCas9	negative selection	7078840
13110310	13110333	10	+	27260156	K562	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.8192989561615805	[368]	[638,753,643,316]	9	hSpCas9	negative selection	7135834
13116315	13116338	10	+	27260156	K562	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.13789812527463657	[349]	[158,285,512,172]	-2	hSpCas9	negative selection	7135835
13110380	13110403	10	+	27260156	K562	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-1.424249555919647	[219]	[100,17,68,98]	-9	hSpCas9	negative selection	7135836
13116316	13116339	10	-	27260156	K562	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.028680769967748876	[362]	[196,286,265,480]	0	hSpCas9	negative selection	7200089
13112476	13112499	10	+	27260156	K562	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.1667859789134374	[11]	[11,39,43,1]	9	hSpCas9	negative selection	7200090
13112551	13112574	10	-	27260156	K562	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.39761389974658823	[685]	[586,323,1394,849]	5	hSpCas9	negative selection	7200091
13110310	13110333	10	+	27260156	HT29	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.5045818504760253	[368]	[801,586,762,423]	8	hSpCas9	negative selection	7257085
13116315	13116338	10	+	27260156	HT29	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.24669756265989434	[349]	[451,394,262,334]	-5	hSpCas9	negative selection	7257086
13110380	13110403	10	+	27260156	HT29	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	0.26161140934794136	[219]	[347,284,431,225]	5	hSpCas9	negative selection	7257087
13116316	13116339	10	-	27260156	HT29	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.011720892420507667	[362]	[642,524,327,292]	0	hSpCas9	negative selection	7321340
13112476	13112499	10	+	27260156	HT29	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.4939787136352316	[11]	[53,35,54,21]	9	hSpCas9	negative selection	7321341
13112551	13112574	10	-	27260156	HT29	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.11666037687932074	[685]	[1203,864,874,709]	2	hSpCas9	negative selection	7321342
13110310	13110333	10	+	27260156	MHHES1	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.49591021759161136	[368]	[740,589,407,604]	8	hSpCas9	negative selection	7378336
13116315	13116338	10	+	27260156	MHHES1	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.43235842070298586	[349]	[480,358,220,160]	-7	hSpCas9	negative selection	7378337
13110380	13110403	10	+	27260156	MHHES1	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.21041104987972692	[219]	[157,123,266,272]	-4	hSpCas9	negative selection	7378338
13116316	13116339	10	-	27260156	MHHES1	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.10661047501542903	[362]	[377,530,168,432]	-2	hSpCas9	negative selection	7442591
13112476	13112499	10	+	27260156	MHHES1	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	-0.6072187850173627	[11]	[12,0,1,16]	-8	hSpCas9	negative selection	7442592
13112551	13112574	10	-	27260156	MHHES1	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.013415994404277654	[685]	[892,771,823,654]	0	hSpCas9	negative selection	7442593
13110310	13110333	10	+	27260156	MEWO	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.6222589346437652	[368]	[556,536,504]	9	hSpCas9	negative selection	7499587
13116315	13116338	10	+	27260156	MEWO	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.2917859642171596	[349]	[347,267,201]	-6	hSpCas9	negative selection	7499588
13110380	13110403	10	+	27260156	MEWO	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.2232209256812634	[219]	[227,161,148]	-5	hSpCas9	negative selection	7499589
13116316	13116339	10	-	27260156	MEWO	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	0.010744959637583151	[362]	[512,232,313]	0	hSpCas9	negative selection	7563842
13112476	13112499	10	+	27260156	MEWO	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	-1.1259275070836603	[11]	[7,1,5]	-9	hSpCas9	negative selection	7563843
13112551	13112574	10	-	27260156	MEWO	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.1415843254637582	[685]	[799,624,716]	3	hSpCas9	negative selection	7563844
13110310	13110333	10	+	27260156	LNCAPCLONEFGC	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.660918939257392	[368]	[498,444,617,570]	9	hSpCas9	negative selection	7620838
13116315	13116338	10	+	27260156	LNCAPCLONEFGC	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.5600200789042764	[349]	[279,191,131,243]	-7	hSpCas9	negative selection	7620839
13110380	13110403	10	+	27260156	LNCAPCLONEFGC	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.04807204863863568	[219]	[201,260,123,168]	0	hSpCas9	negative selection	7620840
13116316	13116339	10	-	27260156	LNCAPCLONEFGC	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.2786109036262168	[362]	[202,354,264,255]	-4	hSpCas9	negative selection	7685093
13112476	13112499	10	+	27260156	LNCAPCLONEFGC	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.5575608376679169	[11]	[13,17,9,20]	8	hSpCas9	negative selection	7685094
13112551	13112574	10	-	27260156	LNCAPCLONEFGC	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	-0.01803087408940396	[685]	[652,602,651,551]	0	hSpCas9	negative selection	7685095
13110310	13110333	10	+	27260156	PANC0327	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.42603600662920305	[368]	[619,395,452,312]	6	hSpCas9	negative selection	7742089
13116315	13116338	10	+	27260156	PANC0327	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	0.2150292232750418	[349]	[395,524,256,246]	3	hSpCas9	negative selection	7742090
13110380	13110403	10	+	27260156	PANC0327	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	0.5984228053959316	[219]	[609,234,197,173]	8	hSpCas9	negative selection	7742091
13116316	13116339	10	-	27260156	PANC0327	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.49788561716669827	[362]	[234,219,256,202]	-6	hSpCas9	negative selection	7806344
13112476	13112499	10	+	27260156	PANC0327	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.3298158163549907	[11]	[1,33,12,0]	5	hSpCas9	negative selection	7806345
13112551	13112574	10	-	27260156	PANC0327	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	-0.17292569890911091	[685]	[490,608,481,566]	-3	hSpCas9	negative selection	7806346
13110310	13110333	10	+	27260156	NCIH2009	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.38826705271423717	[368]	[616,824,566]	5	hSpCas9	negative selection	7863340
13116315	13116338	10	+	27260156	NCIH2009	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	0.24580326585161183	[349]	[405,423,876]	3	hSpCas9	negative selection	7863341
13110380	13110403	10	+	27260156	NCIH2009	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.298221855413181	[219]	[293,315,146]	-4	hSpCas9	negative selection	7863342
13116316	13116339	10	-	27260156	NCIH2009	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.3002194202118789	[362]	[401,356,474]	-4	hSpCas9	negative selection	7927595
13112476	13112499	10	+	27260156	NCIH2009	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.038259732266547886	[11]	[8,16,23]	0	hSpCas9	negative selection	7927596
13112551	13112574	10	-	27260156	NCIH2009	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.1402449545562754	[685]	[1277,886,1048]	2	hSpCas9	negative selection	7927597
13110310	13110333	10	+	27260156	NCIH1373	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.12983080383356888	[368]	[477,392,419,139]	1	hSpCas9	negative selection	7984591
13116315	13116338	10	+	27260156	NCIH1373	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	0.7237221259359172	[349]	[300,168,856,339]	7	hSpCas9	negative selection	7984592
13110380	13110403	10	+	27260156	NCIH1373	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.10468838520390045	[219]	[300,230,195,51]	-1	hSpCas9	negative selection	7984593
13116316	13116339	10	-	27260156	NCIH1373	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	0.06321060805177953	[362]	[800,393,347,53]	0	hSpCas9	negative selection	8048846
13112476	13112499	10	+	27260156	NCIH1373	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.3002255159653542	[11]	[11,3,108,0]	9	hSpCas9	negative selection	8048847
13112551	13112574	10	-	27260156	NCIH1373	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.9175115031273801	[685]	[983,1170,1183,653]	8	hSpCas9	negative selection	8048848
13110310	13110333	10	+	27260156	PATU8902	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.10559544983321603	[368]	[476,896,384,485]	1	hSpCas9	negative selection	8105842
13116315	13116338	10	+	27260156	PATU8902	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.342216931036112	[349]	[575,625,225,113]	-3	hSpCas9	negative selection	8105843
13110380	13110403	10	+	27260156	PATU8902	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	0.07447204497658344	[219]	[333,398,263,303]	0	hSpCas9	negative selection	8105844
13116316	13116339	10	-	27260156	PATU8902	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	0.1277550215200685	[362]	[423,465,626,685]	1	hSpCas9	negative selection	8170097
13112476	13112499	10	+	27260156	PATU8902	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.4211092672721461	[11]	[90,49,32,1]	9	hSpCas9	negative selection	8170098
13112551	13112574	10	-	27260156	PATU8902	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.1241720540156408	[685]	[890,1331,817,1194]	1	hSpCas9	negative selection	8170099
13110310	13110333	10	+	27260156	PANC1	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.45034734909630525	[368]	[317,744,456,294]	7	hSpCas9	negative selection	8227093
13116315	13116338	10	+	27260156	PANC1	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	0.05976500365357157	[349]	[300,327,425,213]	0	hSpCas9	negative selection	8227094
13110380	13110403	10	+	27260156	PANC1	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.40553894536265833	[219]	[85,212,122,158]	-6	hSpCas9	negative selection	8227095
13116316	13116339	10	-	27260156	PANC1	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.018155509401402536	[362]	[189,538,305,250]	0	hSpCas9	negative selection	8291348
13112476	13112499	10	+	27260156	PANC1	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	-0.16265126506777605	[11]	[11,18,7,0]	-3	hSpCas9	negative selection	8291349
13112551	13112574	10	-	27260156	PANC1	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.16919916916906552	[685]	[691,782,696,515]	2	hSpCas9	negative selection	8291350
13110310	13110333	10	+	27260156	PANC0813	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.6892660531047203	[368]	[623,874,744,551]	9	hSpCas9	negative selection	8348344
13116315	13116338	10	+	27260156	PANC0813	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.19629795827951918	[349]	[464,225,415,338]	-3	hSpCas9	negative selection	8348345
13110380	13110403	10	+	27260156	PANC0813	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.3419423404117212	[219]	[276,266,153,127]	-5	hSpCas9	negative selection	8348346
13116316	13116339	10	-	27260156	PANC0813	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.007288639381869133	[362]	[381,543,514,260]	0	hSpCas9	negative selection	8412599
13112476	13112499	10	+	27260156	PANC0813	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.1625125413686987	[11]	[72,45,0,10]	9	hSpCas9	negative selection	8412600
13112551	13112574	10	-	27260156	PANC0813	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.0496642228215074	[685]	[946,908,752,740]	0	hSpCas9	negative selection	8412601
13110310	13110333	10	+	27260156	RDES	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.419046965736242	[368]	[456,558,557,726]	6	hSpCas9	negative selection	8469595
13116315	13116338	10	+	27260156	RDES	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.51732608678811	[349]	[159,214,452,337]	-7	hSpCas9	negative selection	8469596
13110380	13110403	10	+	27260156	RDES	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.02885445050255364	[219]	[192,197,374,238]	0	hSpCas9	negative selection	8469597
13116316	13116339	10	-	27260156	RDES	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.2662495108648149	[362]	[254,419,387,325]	-4	hSpCas9	negative selection	8533850
13112476	13112499	10	+	27260156	RDES	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.4621270585647395	[11]	[46,18,16,71]	9	hSpCas9	negative selection	8533851
13112551	13112574	10	-	27260156	RDES	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.003757879048061019	[685]	[669,632,864,1056]	0	hSpCas9	negative selection	8533852
13110310	13110333	10	+	27260156	PC3	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.7036018593718527	[368]	[480,453,976,619]	9	hSpCas9	negative selection	8590846
13116315	13116338	10	+	27260156	PC3	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.507414504099899	[349]	[193,241,347,229]	-8	hSpCas9	negative selection	8590847
13110380	13110403	10	+	27260156	PC3	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	0.2055672113898278	[219]	[165,300,366,229]	4	hSpCas9	negative selection	8590848
13116316	13116339	10	-	27260156	PC3	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.272529364344599	[362]	[243,199,449,358]	-6	hSpCas9	negative selection	8655101
13112476	13112499	10	+	27260156	PC3	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.5540337626606728	[11]	[0,40,15,16]	9	hSpCas9	negative selection	8655102
13112551	13112574	10	-	27260156	PC3	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.19049396441510114	[685]	[528,919,1257,611]	4	hSpCas9	negative selection	8655103
13110310	13110333	10	+	27260156	PATU8988T	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.5670223493051434	[368]	[402,520,690,491]	8	hSpCas9	negative selection	8712097
13116315	13116338	10	+	27260156	PATU8988T	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.36712198903420795	[349]	[251,180,286,325]	-6	hSpCas9	negative selection	8712098
13110380	13110403	10	+	27260156	PATU8988T	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-1.1384877140915022	[219]	[81,106,102,94]	-9	hSpCas9	negative selection	8712099
13116316	13116339	10	-	27260156	PATU8988T	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.07796324193834353	[362]	[350,221,370,377]	-1	hSpCas9	negative selection	8776352
13112476	13112499	10	+	27260156	PATU8988T	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	2.6498439392525897	[11]	[71,82,104,27]	9	hSpCas9	negative selection	8776353
13112551	13112574	10	-	27260156	PATU8988T	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.23698955115692444	[685]	[953,745,567,862]	4	hSpCas9	negative selection	8776354
13110310	13110333	10	+	27260156	T47D	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.5315708235526887	[368]	[618,627,592,645]	9	hSpCas9	negative selection	8833348
13116315	13116338	10	+	27260156	T47D	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.4183901463260918	[349]	[288,343,283,299]	-7	hSpCas9	negative selection	8833349
13110380	13110403	10	+	27260156	T47D	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.19124104147460685	[219]	[261,194,211,231]	-4	hSpCas9	negative selection	8833350
13116316	13116339	10	-	27260156	T47D	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.26623119446258164	[362]	[336,284,371,419]	-5	hSpCas9	negative selection	8897603
13112476	13112499	10	+	27260156	T47D	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.543149321868345	[11]	[15,24,20,18]	9	hSpCas9	negative selection	8897604
13112551	13112574	10	-	27260156	T47D	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	-0.08589462088463795	[685]	[711,712,788,801]	-2	hSpCas9	negative selection	8897605
13110310	13110333	10	+	27260156	SU8686	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.3957826011328868	[368]	[491,447,518,463]	6	hSpCas9	negative selection	8954599
13116315	13116338	10	+	27260156	SU8686	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.29959658628105473	[349]	[310,271,219,325]	-5	hSpCas9	negative selection	8954600
13110380	13110403	10	+	27260156	SU8686	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.18018451045410844	[219]	[165,189,216,200]	-3	hSpCas9	negative selection	8954601
13116316	13116339	10	-	27260156	SU8686	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.2501677898611206	[362]	[347,177,328,376]	-4	hSpCas9	negative selection	9018854
13112476	13112499	10	+	27260156	SU8686	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	-0.3186112516744197	[11]	[21,9,1,0]	-5	hSpCas9	negative selection	9018855
13112551	13112574	10	-	27260156	SU8686	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.22419082988473626	[685]	[755,759,809,866]	4	hSpCas9	negative selection	9018856
13110310	13110333	10	+	27260156	SKES1	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.5107010196200003	[368]	[683,516,418,497]	8	hSpCas9	negative selection	9075850
13116315	13116338	10	+	27260156	SKES1	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.11399989933296201	[349]	[384,411,175,333]	-2	hSpCas9	negative selection	9075851
13110380	13110403	10	+	27260156	SKES1	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	0.24815552334392155	[219]	[222,303,273,240]	5	hSpCas9	negative selection	9075852
13116316	13116339	10	-	27260156	SKES1	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.01600211663492973	[362]	[375,336,309,400]	0	hSpCas9	negative selection	9140105
13112476	13112499	10	+	27260156	SKES1	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	0.01564407084965147	[11]	[9,11,3,20]	0	hSpCas9	negative selection	9140106
13112551	13112574	10	-	27260156	SKES1	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	-0.10354915497463274	[685]	[583,614,661,665]	-2	hSpCas9	negative selection	9140107
13110310	13110333	10	+	27260156	TOV112D	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.29794723743166646	[368]	[474,604,376,399]	5	hSpCas9	negative selection	9197101
13116315	13116338	10	+	27260156	TOV112D	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-1.11085386939143	[349]	[203,179,152,120]	-9	hSpCas9	negative selection	9197102
13110380	13110403	10	+	27260156	TOV112D	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	0.11633363562129861	[219]	[304,297,237,136]	2	hSpCas9	negative selection	9197103
13116316	13116339	10	-	27260156	TOV112D	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.017680010326379336	[362]	[406,358,316,356]	0	hSpCas9	negative selection	9261356
13112476	13112499	10	+	27260156	TOV112D	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.003394933547935	[11]	[4,92,0,12]	9	hSpCas9	negative selection	9261357
13112551	13112574	10	-	27260156	TOV112D	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.19124658211605872	[685]	[904,770,814,655]	3	hSpCas9	negative selection	9261358
13110310	13110333	10	+	27260156	TC71	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.43872085937437705	[368]	[563,459,465,663]	8	hSpCas9	negative selection	9318352
13116315	13116338	10	+	27260156	TC71	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.31433496319646886	[349]	[352,300,324,220]	-7	hSpCas9	negative selection	9318353
13110380	13110403	10	+	27260156	TC71	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.015816266036554394	[219]	[207,241,249,232]	0	hSpCas9	negative selection	9318354
13116316	13116339	10	-	27260156	TC71	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.1613793598546212	[362]	[343,377,308,362]	-4	hSpCas9	negative selection	9382607
13112476	13112499	10	+	27260156	TC71	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	-0.1267551057930527	[11]	[2,6,13,23]	-3	hSpCas9	negative selection	9382608
13112551	13112574	10	-	27260156	TC71	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	0.09919975319039875	[685]	[826,721,881,710]	2	hSpCas9	negative selection	9382609
13110310	13110333	10	+	27260156	TC32	viability	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.5790535239134114	[368]	[485,475,538,563]	8	hSpCas9	negative selection	9439603
13116315	13116338	10	+	27260156	TC32	viability	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.7180792744990052	[349]	[170,78,322,292]	-8	hSpCas9	negative selection	9439604
13110380	13110403	10	+	27260156	TC32	viability	AGAAGCAAAAGAGCGTCTAATGG	OPTN	ENSG00000123240	-0.28374047306684136	[219]	[158,196,127,166]	-5	hSpCas9	negative selection	9439605
13116316	13116339	10	-	27260156	TC32	viability	GCCAGTGGAGACTGTTCTCGTGG	OPTN	ENSG00000123240	-0.4402940290685749	[362]	[248,210,227,316]	-7	hSpCas9	negative selection	9503858
13112476	13112499	10	+	27260156	TC32	viability	TCCCAGGGCCGAAGCGGAGCAGG	OPTN	ENSG00000123240	1.1326836269782588	[11]	[22,11,34,34]	9	hSpCas9	negative selection	9503859
13112551	13112574	10	-	27260156	TC32	viability	GTTCAGACACGATGCCCAACAGG	OPTN	ENSG00000123240	-0.044290769743208336	[685]	[633,396,891,675]	0	hSpCas9	negative selection	9503860
13109200	13109223	10	-	27869803	HPAFII	viability after 27 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	1.6461911646032281	[127]	[298,136,NaN]	9	hSpCas9	negative selection	9537246
13110310	13110333	10	+	27869803	HPAFII	viability after 27 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	1.136167076187121	[44]	[9,86,NaN]	8	hSpCas9	negative selection	9537247
13112518	13112541	10	-	27869803	HPAFII	viability after 27 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	-0.045487826158830263	[274]	[204,85,NaN]	0	hSpCas9	negative selection	9537248
13116315	13116338	10	+	27869803	HPAFII	viability after 27 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-1.587218474661524	[331]	[8,98,NaN]	-7	hSpCas9	negative selection	9537252
13119008	13119031	10	+	27869803	HPAFII	viability after 27 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.6713220195672868	[223]	[102,257,NaN]	5	hSpCas9	negative selection	9537253
13123988	13124011	10	+	27869803	HPAFII	viability after 27 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.6681115138435232	[168]	[240,57,NaN]	5	hSpCas9	negative selection	9537254
13109200	13109223	10	-	27869803	HPAFII	viability after 15 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	0.6988446103436232	[127]	[189,243,NaN]	7	hSpCas9	negative selection	9619695
13110310	13110333	10	+	27869803	HPAFII	viability after 15 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.029558777381100132	[44]	[20,66,NaN]	0	hSpCas9	negative selection	9619696
13112518	13112541	10	-	27869803	HPAFII	viability after 15 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.3326091474204145	[274]	[550,260,NaN]	4	hSpCas9	negative selection	9619697
13116315	13116338	10	+	27869803	HPAFII	viability after 15 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.9661720662446585	[331]	[54,261,NaN]	-7	hSpCas9	negative selection	9619701
13119008	13119031	10	+	27869803	HPAFII	viability after 15 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.18791171746540847	[223]	[235,297,NaN]	2	hSpCas9	negative selection	9619702
13123988	13124011	10	+	27869803	HPAFII	viability after 15 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.9092450490493764	[168]	[633,158,NaN]	8	hSpCas9	negative selection	9619703
13109200	13109223	10	-	27869803	ASPC1	viability after 36 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	0.333124727519296	[434]	[15,503,63]	3	hSpCas9	negative selection	9702144
13110310	13110333	10	+	27869803	ASPC1	viability after 36 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	0.26740533796879573	[142]	[57,30,83]	2	hSpCas9	negative selection	9702145
13112518	13112541	10	-	27869803	ASPC1	viability after 36 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.2407768702691403	[801]	[280,572,169]	2	hSpCas9	negative selection	9702146
13116315	13116338	10	+	27869803	ASPC1	viability after 36 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.4266772089925174	[587]	[91,339,44]	-4	hSpCas9	negative selection	9702150
13119008	13119031	10	+	27869803	ASPC1	viability after 36 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	-0.4863029138136815	[551]	[181,110,125]	-5	hSpCas9	negative selection	9702151
13123988	13124011	10	+	27869803	ASPC1	viability after 36 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.04996967209072939	[472]	[192,138,178]	0	hSpCas9	negative selection	9702152
13109200	13109223	10	-	27869803	PATU8988S	viability after 35 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	0.5169592212327657	[380]	[251,186,NaN]	6	hSpCas9	negative selection	9784593
13110310	13110333	10	+	27869803	PATU8988S	viability after 35 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-0.9740442555610067	[116]	[18,28,NaN]	-7	hSpCas9	negative selection	9784594
13112518	13112541	10	-	27869803	PATU8988S	viability after 35 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.2809142571194533	[463]	[247,205,NaN]	3	hSpCas9	negative selection	9784595
13116315	13116338	10	+	27869803	PATU8988S	viability after 35 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.9374651392539596	[593]	[87,161,NaN]	-7	hSpCas9	negative selection	9784599
13119008	13119031	10	+	27869803	PATU8988S	viability after 35 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.2422439769423576	[517]	[363,128,NaN]	3	hSpCas9	negative selection	9784600
13123988	13124011	10	+	27869803	PATU8988S	viability after 35 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	-0.5529567815097379	[476]	[107,153,NaN]	-5	hSpCas9	negative selection	9784601
13109200	13109223	10	-	27869803	PATU8988S	viability after 31 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	-0.25076255323788266	[380]	[139,111,NaN]	-3	hSpCas9	negative selection	9867042
13110310	13110333	10	+	27869803	PATU8988S	viability after 31 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	-1.151424331987228	[116]	[31,6,NaN]	-8	hSpCas9	negative selection	9867043
13112518	13112541	10	-	27869803	PATU8988S	viability after 31 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.17830071392697489	[463]	[189,233,NaN]	2	hSpCas9	negative selection	9867044
13116315	13116338	10	+	27869803	PATU8988S	viability after 31 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-0.38281006126454686	[593]	[50,347,NaN]	-4	hSpCas9	negative selection	9867048
13119008	13119031	10	+	27869803	PATU8988S	viability after 31 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.3537184075478906	[517]	[354,147,NaN]	4	hSpCas9	negative selection	9867049
13123988	13124011	10	+	27869803	PATU8988S	viability after 31 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	-0.28635356631320474	[476]	[151,160,NaN]	-3	hSpCas9	negative selection	9867050
13109200	13109223	10	-	27869803	HPAFII	viability after 35 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	2.5828682449240943	[127]	[502,258,NaN]	9	hSpCas9	negative selection	9949491
13110310	13110333	10	+	27869803	HPAFII	viability after 35 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	1.542900154266761	[44]	[0,139,NaN]	9	hSpCas9	negative selection	9949492
13112518	13112541	10	-	27869803	HPAFII	viability after 35 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.2850687812567144	[274]	[258,68,NaN]	1	hSpCas9	negative selection	9949493
13116315	13116338	10	+	27869803	HPAFII	viability after 35 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-1.1761954364020026	[331]	[0,156,NaN]	-6	hSpCas9	negative selection	9949497
13119008	13119031	10	+	27869803	HPAFII	viability after 35 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.5322508646994859	[223]	[36,306,NaN]	3	hSpCas9	negative selection	9949498
13123988	13124011	10	+	27869803	HPAFII	viability after 35 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.618283962402647	[168]	[207,44,NaN]	4	hSpCas9	negative selection	9949499
13109200	13109223	10	-	27869803	HPAFII	viability after 31 days	TGTCCAGGTTTGGGTGGGCCAGG	OPTN	ENSG00000123240	2.280100056937071	[127]	[413,277,NaN]	9	hSpCas9	negative selection	10031940
13110310	13110333	10	+	27869803	HPAFII	viability after 31 days	GATTTGAGGAGCTTTCGGCCTGG	OPTN	ENSG00000123240	1.0135392724496393	[44]	[5,99,NaN]	7	hSpCas9	negative selection	10031941
13112518	13112541	10	-	27869803	HPAFII	viability after 31 days	CTGCTTGTAGCCTCACCACCTGG	OPTN	ENSG00000123240	0.4463884311076528	[274]	[216,202,NaN]	3	hSpCas9	negative selection	10031942
13116315	13116338	10	+	27869803	HPAFII	viability after 31 days	CCCACGAGAACAGTCTCCACTGG	OPTN	ENSG00000123240	-1.080598117638616	[331]	[0,182,NaN]	-6	hSpCas9	negative selection	10031946
13119008	13119031	10	+	27869803	HPAFII	viability after 31 days	ACTTGAAGTTGCACTCAAGGAGG	OPTN	ENSG00000123240	0.5937551042218236	[223]	[82,305,NaN]	4	hSpCas9	negative selection	10031947
13123988	13124011	10	+	27869803	HPAFII	viability after 31 days	ATGATAGGTTGGAAGCGAAGTGG	OPTN	ENSG00000123240	0.9887788380560982	[168]	[315,48,NaN]	7	hSpCas9	negative selection	10031948
13112457	13112480	10	-	28162770	P31FUJ	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	-0.8256268229085051	[91]	[60]	-6	hSpCas9	negative selection	10204957
13110326	13110349	10	+	28162770	P31FUJ	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	1.0053575327803856	[38]	[91]	9	hSpCas9	negative selection	10204958
13112503	13112526	10	+	28162770	P31FUJ	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-1.3371388642291144	[42]	[19]	-7	hSpCas9	negative selection	10204959
13112524	13112547	10	+	28162770	P31FUJ	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	0.3466221127653475	[260]	[389]	4	hSpCas9	negative selection	10204960
13122421	13122444	10	+	28162770	P31FUJ	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	0.03293135102037065	[266]	[320]	0	hSpCas9	negative selection	10204961
13122460	13122483	10	+	28162770	P31FUJ	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	0.5616136619357273	[63]	[110]	6	hSpCas9	negative selection	10204962
13132172	13132195	10	+	28162770	P31FUJ	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	0.34590130583509504	[76]	[114]	4	hSpCas9	negative selection	10204963
13109140	13109163	10	+	28162770	P31FUJ	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	0.6973329887110495	[274]	[523]	7	hSpCas9	negative selection	10204964
13109162	13109185	10	+	28162770	P31FUJ	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	-0.393864637146895	[141]	[126]	-4	hSpCas9	negative selection	10204965
13109229	13109252	10	-	28162770	P31FUJ	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	-0.1971782946836571	[39]	[40]	-2	hSpCas9	negative selection	10204966
13112457	13112480	10	-	28162770	TF1	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	NaN	[NaN]	[38]	1	hSpCas9	negative selection	10374323
13110326	13110349	10	+	28162770	TF1	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	NaN	[NaN]	[1]	1	hSpCas9	negative selection	10374324
13112503	13112526	10	+	28162770	TF1	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	NaN	[NaN]	[2]	1	hSpCas9	negative selection	10374325
13112524	13112547	10	+	28162770	TF1	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	NaN	[NaN]	[123]	1	hSpCas9	negative selection	10374326
13122421	13122444	10	+	28162770	TF1	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	NaN	[NaN]	[149]	1	hSpCas9	negative selection	10374327
13122460	13122483	10	+	28162770	TF1	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	NaN	[NaN]	[25]	1	hSpCas9	negative selection	10374328
13132172	13132195	10	+	28162770	TF1	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	NaN	[NaN]	[18]	1	hSpCas9	negative selection	10374329
13109140	13109163	10	+	28162770	TF1	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	NaN	[NaN]	[143]	1	hSpCas9	negative selection	10374330
13109162	13109185	10	+	28162770	TF1	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	NaN	[NaN]	[61]	1	hSpCas9	negative selection	10374331
13109229	13109252	10	-	28162770	TF1	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	NaN	[NaN]	[45]	1	hSpCas9	negative selection	10374332
13112457	13112480	10	-	28162770	SKM1	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	0.08070110062307978	[22]	[42]	0	hSpCas9	negative selection	10543689
13110326	13110349	10	+	28162770	SKM1	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	-2.8220016980220053	[7]	[1]	-9	hSpCas9	negative selection	10543690
13112503	13112526	10	+	28162770	SKM1	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-1.121561979880913	[15]	[12]	-7	hSpCas9	negative selection	10543691
13112524	13112547	10	+	28162770	SKM1	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	-0.0713611669587228	[62]	[105]	0	hSpCas9	negative selection	10543692
13122421	13122444	10	+	28162770	SKM1	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	-0.56566194476222	[107]	[128]	-4	hSpCas9	negative selection	10543693
13122460	13122483	10	+	28162770	SKM1	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	0.21041977967037195	[21]	[44]	2	hSpCas9	negative selection	10543694
13132172	13132195	10	+	28162770	SKM1	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	1.7502497509495967	[18]	[112]	9	hSpCas9	negative selection	10543695
13109140	13109163	10	+	28162770	SKM1	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	1.2693726549987283	[64]	[276]	9	hSpCas9	negative selection	10543696
13109162	13109185	10	+	28162770	SKM1	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	-0.05148354414477274	[16]	[28]	0	hSpCas9	negative selection	10543697
13109229	13109252	10	-	28162770	SKM1	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	-0.8220016980220057	[6]	[6]	-6	hSpCas9	negative selection	10543698
13112457	13112480	10	-	28162770	SKM1	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	0.08070110062307978	[22]	[42]	0	hSpCas9	negative selection	10713055
13110326	13110349	10	+	28162770	SKM1	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	-2.8220016980220053	[7]	[1]	-9	hSpCas9	negative selection	10713056
13112503	13112526	10	+	28162770	SKM1	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-1.121561979880913	[15]	[12]	-7	hSpCas9	negative selection	10713057
13112524	13112547	10	+	28162770	SKM1	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	-0.0713611669587228	[62]	[105]	0	hSpCas9	negative selection	10713058
13122421	13122444	10	+	28162770	SKM1	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	-0.56566194476222	[107]	[128]	-4	hSpCas9	negative selection	10713059
13122460	13122483	10	+	28162770	SKM1	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	0.21041977967037195	[21]	[44]	2	hSpCas9	negative selection	10713060
13132172	13132195	10	+	28162770	SKM1	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	1.7502497509495967	[18]	[112]	9	hSpCas9	negative selection	10713061
13109140	13109163	10	+	28162770	SKM1	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	1.2693726549987283	[64]	[276]	9	hSpCas9	negative selection	10713062
13109162	13109185	10	+	28162770	SKM1	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	-0.05148354414477274	[16]	[28]	0	hSpCas9	negative selection	10713063
13109229	13109252	10	-	28162770	SKM1	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	-0.8220016980220057	[6]	[6]	-6	hSpCas9	negative selection	10713064
13112457	13112480	10	-	28162770	PL21	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	0.5850571253918285	[120]	[78]	5	hSpCas9	negative selection	10882421
13110326	13110349	10	+	28162770	PL21	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	-0.9467017738399508	[30]	[6]	-6	hSpCas9	negative selection	10882422
13112503	13112526	10	+	28162770	PL21	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-3.4580718682624747	[100]	[3]	-9	hSpCas9	negative selection	10882423
13112524	13112547	10	+	28162770	PL21	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	0.5202287097129015	[313]	[195]	4	hSpCas9	negative selection	10882424
13122421	13122444	10	+	28162770	PL21	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	0.43539086380957603	[366]	[215]	4	hSpCas9	negative selection	10882425
13122460	13122483	10	+	28162770	PL21	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	-1.2946250772602577	[123]	[21]	-7	hSpCas9	negative selection	10882426
13132172	13132195	10	+	28162770	PL21	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	-2.1422525829577577	[70]	[6]	-8	hSpCas9	negative selection	10882427
13109140	13109163	10	+	28162770	PL21	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	0.6919927108189949	[191]	[134]	6	hSpCas9	negative selection	10882428
13109162	13109185	10	+	28162770	PL21	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	-2.1748998168576046	[82]	[7]	-8	hSpCas9	negative selection	10882429
13109229	13109252	10	-	28162770	PL21	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	0.33340614535278457	[30]	[16]	3	hSpCas9	negative selection	10882430
13112457	13112480	10	-	28162770	P31FUJ	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	-0.8256268229085051	[91]	[60]	-6	hSpCas9	negative selection	11051787
13110326	13110349	10	+	28162770	P31FUJ	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	1.0053575327803856	[38]	[91]	9	hSpCas9	negative selection	11051788
13112503	13112526	10	+	28162770	P31FUJ	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-1.3371388642291144	[42]	[19]	-7	hSpCas9	negative selection	11051789
13112524	13112547	10	+	28162770	P31FUJ	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	0.3466221127653475	[260]	[389]	4	hSpCas9	negative selection	11051790
13122421	13122444	10	+	28162770	P31FUJ	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	0.03293135102037065	[266]	[320]	0	hSpCas9	negative selection	11051791
13122460	13122483	10	+	28162770	P31FUJ	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	0.5616136619357273	[63]	[110]	6	hSpCas9	negative selection	11051792
13132172	13132195	10	+	28162770	P31FUJ	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	0.34590130583509504	[76]	[114]	4	hSpCas9	negative selection	11051793
13109140	13109163	10	+	28162770	P31FUJ	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	0.6973329887110495	[274]	[523]	7	hSpCas9	negative selection	11051794
13109162	13109185	10	+	28162770	P31FUJ	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	-0.393864637146895	[141]	[126]	-4	hSpCas9	negative selection	11051795
13109229	13109252	10	-	28162770	P31FUJ	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	-0.1971782946836571	[39]	[40]	-2	hSpCas9	negative selection	11051796
13112457	13112480	10	-	28162770	OCIAML5	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	-0.137043529578468	[52]	[86]	-1	hSpCas9	negative selection	11221153
13110326	13110349	10	+	28162770	OCIAML5	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	-0.07445899220044527	[13]	[23]	0	hSpCas9	negative selection	11221154
13112503	13112526	10	+	28162770	OCIAML5	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-5.852066570863997	[31]	[0]	-9	hSpCas9	negative selection	11221155
13112524	13112547	10	+	28162770	OCIAML5	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	-0.08555670108377555	[173]	[295]	0	hSpCas9	negative selection	11221156
13122421	13122444	10	+	28162770	OCIAML5	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	0.1598401958201774	[180]	[364]	1	hSpCas9	negative selection	11221157
13122460	13122483	10	+	28162770	OCIAML5	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	-2.080885261359878	[74]	[31]	-8	hSpCas9	negative selection	11221158
13132172	13132195	10	+	28162770	OCIAML5	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	-1.1702425308902518	[95]	[76]	-6	hSpCas9	negative selection	11221159
13109140	13109163	10	+	28162770	OCIAML5	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	1.7416661394848911	[81]	[494]	9	hSpCas9	negative selection	11221160
13109162	13109185	10	+	28162770	OCIAML5	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	0.7177890374669509	[31]	[94]	6	hSpCas9	negative selection	11221161
13109229	13109252	10	-	28162770	OCIAML5	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	-0.43702907158515325	[20]	[27]	-3	hSpCas9	negative selection	11221162
13112457	13112480	10	-	28162770	EOL1	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	-1.2526452303358169	[198]	[43]	-7	hSpCas9	negative selection	11390519
13110326	13110349	10	+	28162770	EOL1	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	-1.245377229871778	[26]	[5]	-7	hSpCas9	negative selection	11390520
13112503	13112526	10	+	28162770	EOL1	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-6.141541418887238	[133]	[0]	-9	hSpCas9	negative selection	11390521
13112524	13112547	10	+	28162770	EOL1	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	1.5042353302510167	[547]	[818]	9	hSpCas9	negative selection	11390522
13122421	13122444	10	+	28162770	EOL1	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	0.6184446438448546	[543]	[439]	5	hSpCas9	negative selection	11390523
13122460	13122483	10	+	28162770	EOL1	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	0.19354373564304517	[160]	[96]	1	hSpCas9	negative selection	11390524
13132172	13132195	10	+	28162770	EOL1	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	-1.397380323316828	[59]	[11]	-7	hSpCas9	negative selection	11390525
13109140	13109163	10	+	28162770	EOL1	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	1.1072668852288996	[236]	[268]	8	hSpCas9	negative selection	11390526
13109162	13109185	10	+	28162770	EOL1	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	0.2241080534294424	[116]	[71]	2	hSpCas9	negative selection	11390527
13109229	13109252	10	-	28162770	EOL1	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	-0.8530598070930178	[23]	[6]	-5	hSpCas9	negative selection	11390528
13112457	13112480	10	-	28162770	MOLM13	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	0.7395627056522451	[110]	[133]	5	hSpCas9	negative selection	11559885
13110326	13110349	10	+	28162770	MOLM13	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	-5.023963714785096	[44]	[0]	-9	hSpCas9	negative selection	11559886
13112503	13112526	10	+	28162770	MOLM13	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-3.866011355008859	[120]	[5]	-9	hSpCas9	negative selection	11559887
13112524	13112547	10	+	28162770	MOLM13	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	1.0465103553919082	[303]	[453]	7	hSpCas9	negative selection	11559888
13122421	13122444	10	+	28162770	MOLM13	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	0.4256928178903714	[450]	[437]	3	hSpCas9	negative selection	11559889
13122460	13122483	10	+	28162770	MOLM13	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	-2.0224362450385023	[117]	[20]	-7	hSpCas9	negative selection	11559890
13132172	13132195	10	+	28162770	MOLM13	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	-1.5186901026930995	[106]	[26]	-6	hSpCas9	negative selection	11559891
13109140	13109163	10	+	28162770	MOLM13	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	-0.10730534292775629	[367]	[246]	0	hSpCas9	negative selection	11559892
13109162	13109185	10	+	28162770	MOLM13	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	0.25029794647195214	[99]	[85]	1	hSpCas9	negative selection	11559893
13109229	13109252	10	-	28162770	MOLM13	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	0.35241216412464293	[25]	[23]	2	hSpCas9	negative selection	11559894
13112457	13112480	10	-	28162770	HEL	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	0.7772809553791846	[132]	[145]	6	hSpCas9	negative selection	11729251
13110326	13110349	10	+	28162770	HEL	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	-0.49476469174957804	[43]	[19]	-3	hSpCas9	negative selection	11729252
13112503	13112526	10	+	28162770	HEL	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-2.8536869941191423	[78]	[6]	-8	hSpCas9	negative selection	11729253
13112524	13112547	10	+	28162770	HEL	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	0.21606663223810973	[331]	[246]	1	hSpCas9	negative selection	11729254
13122421	13122444	10	+	28162770	HEL	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	-0.01845925454788444	[407]	[257]	0	hSpCas9	negative selection	11729255
13122460	13122483	10	+	28162770	HEL	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	-0.042625565678636956	[118]	[73]	0	hSpCas9	negative selection	11729256
13132172	13132195	10	+	28162770	HEL	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	-0.4312617494434201	[79]	[37]	-3	hSpCas9	negative selection	11729257
13109140	13109163	10	+	28162770	HEL	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	-0.22893707102410363	[257]	[140]	-2	hSpCas9	negative selection	11729258
13109162	13109185	10	+	28162770	HEL	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	-0.34183112743003696	[92]	[46]	-2	hSpCas9	negative selection	11729259
13109229	13109252	10	-	28162770	HEL	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	0.9942112025017344	[28]	[36]	8	hSpCas9	negative selection	11729260
13112457	13112480	10	-	28162770	MV411	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	0.3791432299945976	[135]	[148]	3	hSpCas9	negative selection	11898617
13110326	13110349	10	+	28162770	MV411	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	-0.7525624492172245	[3]	[1]	-5	hSpCas9	negative selection	11898618
13112503	13112526	10	+	28162770	MV411	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-1.2886153494574346	[57]	[19]	-7	hSpCas9	negative selection	11898619
13112524	13112547	10	+	28162770	MV411	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	0.7861494204481747	[242]	[352]	7	hSpCas9	negative selection	11898620
13122421	13122444	10	+	28162770	MV411	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	0.09679613279595056	[352]	[317]	0	hSpCas9	negative selection	11898621
13122460	13122483	10	+	28162770	MV411	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	-1.3375249499383808	[101]	[33]	-7	hSpCas9	negative selection	11898622
13132172	13132195	10	+	28162770	MV411	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	0.6307661903342807	[22]	[29]	6	hSpCas9	negative selection	11898623
13109140	13109163	10	+	28162770	MV411	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	0.7996101163862621	[177]	[260]	7	hSpCas9	negative selection	11898624
13109162	13109185	10	+	28162770	MV411	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	1.4752434683055875	[37]	[88]	9	hSpCas9	negative selection	11898625
13109229	13109252	10	-	28162770	MV411	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	-0.30510347224600354	[21]	[14]	-2	hSpCas9	negative selection	11898626
13112457	13112480	10	-	28162770	MONOMAC1	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	0.32971103971630666	[58]	[84]	3	hSpCas9	negative selection	12067983
13110326	13110349	10	+	28162770	MONOMAC1	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	-0.8491135436392465	[10]	[6]	-6	hSpCas9	negative selection	12067984
13112503	13112526	10	+	28162770	MONOMAC1	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-2.5662706567252727	[30]	[5]	-9	hSpCas9	negative selection	12067985
13112524	13112547	10	+	28162770	MONOMAC1	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	0.512513289526252	[169]	[277]	5	hSpCas9	negative selection	12067986
13122421	13122444	10	+	28162770	MONOMAC1	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	0.5052210125205179	[243]	[396]	5	hSpCas9	negative selection	12067987
13122460	13122483	10	+	28162770	MONOMAC1	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	0.4361808222688237	[48]	[75]	4	hSpCas9	negative selection	12067988
13132172	13132195	10	+	28162770	MONOMAC1	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	0.6352357072023799	[40]	[72]	6	hSpCas9	negative selection	12067989
13109140	13109163	10	+	28162770	MONOMAC1	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	1.6685129531680654	[117]	[429]	9	hSpCas9	negative selection	12067990
13109162	13109185	10	+	28162770	MONOMAC1	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	1.1899862760496938	[38]	[101]	9	hSpCas9	negative selection	12067991
13109229	13109252	10	-	28162770	MONOMAC1	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	-1.0450337536145033	[17]	[9]	-7	hSpCas9	negative selection	12067992
13112457	13112480	10	-	28162770	OCIAML2	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	0.1616383902573516	[19]	[123]	1	hSpCas9	negative selection	12237349
13110326	13110349	10	+	28162770	OCIAML2	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	-0.5775450291586735	[6]	[25]	-4	hSpCas9	negative selection	12237350
13112503	13112526	10	+	28162770	OCIAML2	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-6.377520420850679	[14]	[0]	-9	hSpCas9	negative selection	12237351
13112524	13112547	10	+	28162770	OCIAML2	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	0.21930223508053748	[52]	[341]	2	hSpCas9	negative selection	12237352
13122421	13122444	10	+	28162770	OCIAML2	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	-0.05969672429605388	[65]	[350]	0	hSpCas9	negative selection	12237353
13122460	13122483	10	+	28162770	OCIAML2	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	0.747793693891341	[12]	[120]	7	hSpCas9	negative selection	12237354
13132172	13132195	10	+	28162770	OCIAML2	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	0.43626077036635724	[7]	[59]	4	hSpCas9	negative selection	12237355
13109140	13109163	10	+	28162770	OCIAML2	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	0.9508339431961156	[27]	[299]	8	hSpCas9	negative selection	12237356
13109162	13109185	10	+	28162770	OCIAML2	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	-0.6722636864118118	[22]	[79]	-5	hSpCas9	negative selection	12237357
13109229	13109252	10	-	28162770	OCIAML2	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	-1.3551526078222254	[5]	[12]	-7	hSpCas9	negative selection	12237358
13112457	13112480	10	-	28162770	OCIAML3	viability	GGGAAGCCTGGAGTCATCAGTGG	OPTN	ENSG00000123240	0.5090858526399404	[26]	[115]	5	hSpCas9	negative selection	12406715
13110326	13110349	10	+	28162770	OCIAML3	viability	GGCCTGGACAGAGAAACAGAAGG	OPTN	ENSG00000123240	1.4416162694065577	[4]	[40]	9	hSpCas9	negative selection	12406716
13112503	13112526	10	+	28162770	OCIAML3	viability	GGACCAGCTCAGGACCCAGGTGG	OPTN	ENSG00000123240	-2.751548917310643	[28]	[12]	-9	hSpCas9	negative selection	12406717
13112524	13112547	10	+	28162770	OCIAML3	viability	GGTGAGGCTACAAGCAGAGAAGG	OPTN	ENSG00000123240	-0.9091037017291003	[78]	[126]	-6	hSpCas9	negative selection	12406718
13122421	13122444	10	+	28162770	OCIAML3	viability	TGAGATTGAAACCCAGACAGAGG	OPTN	ENSG00000123240	0.28200364240038334	[84]	[311]	2	hSpCas9	negative selection	12406719
13122460	13122483	10	+	28162770	OCIAML3	viability	GAATGATGAAGAGAAAGGCCCGG	OPTN	ENSG00000123240	-3.51154548013219	[33]	[8]	-9	hSpCas9	negative selection	12406720
13132172	13132195	10	+	28162770	OCIAML3	viability	AATGATGCTTTCGAAGACGGAGG	OPTN	ENSG00000123240	0.034023582288878806	[10]	[33]	0	hSpCas9	negative selection	12406721
13109140	13109163	10	+	28162770	OCIAML3	viability	CAGCTGCCTCACTGAAAAGGAGG	OPTN	ENSG00000123240	-0.3071264925360017	[49]	[121]	-2	hSpCas9	negative selection	12406722
13109162	13109185	10	+	28162770	OCIAML3	viability	GACAGCCCCAGTGAAAGCACAGG	OPTN	ENSG00000123240	-0.8439858933325106	[21]	[36]	-6	hSpCas9	negative selection	12406723
13109229	13109252	10	-	28162770	OCIAML3	viability	CTGCTGCAGCAGCTCCTCCGGGG	OPTN	ENSG00000123240	-0.7126521368227821	[18]	[34]	-5	hSpCas9	negative selection	12406724