Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 5291
• Symbol: PIK3CB
• Description: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

DataSource: http://genomecrispr.dkfz.de/#!/results/PIK3CB

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
138684722	138684745	3	-	26472758	Jiyoye	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.5446789052558085	[69]	[76]	4	hSpCas9	negative selection	120718
138759286	138759309	3	-	26472758	Jiyoye	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	-1.113396531945328	[240]	[83]	-6	hSpCas9	negative selection	120719
138759212	138759235	3	+	26472758	Jiyoye	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	0.9376900982046534	[80]	[116]	6	hSpCas9	negative selection	120720
138759183	138759206	3	+	26472758	Jiyoye	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	4.655102894949458	[0]	[18]	9	hSpCas9	negative selection	120721
138684656	138684679	3	+	26472758	Jiyoye	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	0.40717538150587274	[0]	[0]	3	hSpCas9	negative selection	120722
138755793	138755816	3	-	26472758	Jiyoye	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.5792361272921768	[149]	[168]	4	hSpCas9	negative selection	120723
138691066	138691089	3	+	26472758	Jiyoye	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	-0.3207450730573256	[52]	[31]	-2	hSpCas9	negative selection	120724
138665139	138665162	3	+	26472758	Jiyoye	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	-0.854316859519515	[186]	[77]	-5	hSpCas9	negative selection	120725
138656249	138656272	3	+	26472758	Jiyoye	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	-0.34432630581821316	[132]	[78]	-2	hSpCas9	negative selection	120726
138759300	138759323	3	+	26472758	Jiyoye	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	0.2942111329165563	[238]	[220]	2	hSpCas9	negative selection	120727
138684722	138684745	3	-	26472758	KBM7	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.3416412685195154	[436,423]	[363,161]	3	hSpCas9	negative selection	311836
138759286	138759309	3	-	26472758	KBM7	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.3029748298551223	[588,657]	[516,229]	3	hSpCas9	negative selection	311837
138759212	138759235	3	+	26472758	KBM7	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	-0.14943152547331606	[367,256]	[154,108]	-1	hSpCas9	negative selection	311838
138759183	138759206	3	+	26472758	KBM7	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-0.7356953177179046	[89,63]	[21,20]	-6	hSpCas9	negative selection	311839
138684656	138684679	3	+	26472758	KBM7	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	1.0564246533638157	[40,31]	[36,33]	9	hSpCas9	negative selection	311840
138755793	138755816	3	-	26472758	KBM7	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.6635095500864401	[764,500]	[639,305]	7	hSpCas9	negative selection	311841
138691066	138691089	3	+	26472758	KBM7	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	0.3469417372833411	[330,343]	[321,96]	3	hSpCas9	negative selection	311842
138665139	138665162	3	+	26472758	KBM7	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	0.295049568765903	[349,323]	[258,136]	3	hSpCas9	negative selection	311843
138656249	138656272	3	+	26472758	KBM7	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	0.07266695182648386	[679,809]	[241,490]	0	hSpCas9	negative selection	311844
138759300	138759323	3	+	26472758	KBM7	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	0.32569054941969	[1389,1081]	[531,892]	3	hSpCas9	negative selection	311845
138684722	138684745	3	-	26472758	Raji	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.5605561635392143	[335]	[114]	5	hSpCas9	negative selection	502954
138759286	138759309	3	-	26472758	Raji	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	-0.5389795100116999	[431]	[68]	-4	hSpCas9	negative selection	502955
138759212	138759235	3	+	26472758	Raji	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	0.5029248590266461	[148]	[48]	5	hSpCas9	negative selection	502956
138759183	138759206	3	+	26472758	Raji	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-0.06254146606871291	[44]	[9]	0	hSpCas9	negative selection	502957
138684656	138684679	3	+	26472758	Raji	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	-0.06254146606871291	[26]	[5]	0	hSpCas9	negative selection	502958
138755793	138755816	3	-	26472758	Raji	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	1.1279938150488855	[277]	[140]	8	hSpCas9	negative selection	502959
138691066	138691089	3	+	26472758	Raji	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	0.5417863595193744	[147]	[49]	5	hSpCas9	negative selection	502960
138665139	138665162	3	+	26472758	Raji	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	1.3243705736879565	[190]	[110]	9	hSpCas9	negative selection	502961
138656249	138656272	3	+	26472758	Raji	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	0.27484028122516246	[259]	[72]	2	hSpCas9	negative selection	502962
138759300	138759323	3	+	26472758	Raji	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	-0.13897212931356417	[687]	[144]	-1	hSpCas9	negative selection	502963
138684722	138684745	3	-	26472758	K562	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.8342900287712257	[488]	[735]	7	hSpCas9	negative selection	694072
138759286	138759309	3	-	26472758	K562	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	1.1516165738438806	[625]	[1173]	8	hSpCas9	negative selection	694073
138759212	138759235	3	+	26472758	K562	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	-0.42543267064122237	[244]	[153]	-3	hSpCas9	negative selection	694074
138759183	138759206	3	+	26472758	K562	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-1.2940011871176793	[60]	[20]	-6	hSpCas9	negative selection	694075
138684656	138684679	3	+	26472758	K562	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	-5.31017012401119	[46]	[0]	-9	hSpCas9	negative selection	694076
138755793	138755816	3	-	26472758	K562	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.03436296617523177	[523]	[452]	0	hSpCas9	negative selection	694077
138691066	138691089	3	+	26472758	K562	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	-0.0338824348206575	[284]	[234]	0	hSpCas9	negative selection	694078
138665139	138665162	3	+	26472758	K562	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	0.5987021958661942	[290]	[371]	5	hSpCas9	negative selection	694079
138656249	138656272	3	+	26472758	K562	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	0.39944001267441154	[572]	[637]	3	hSpCas9	negative selection	694080
138759300	138759323	3	+	26472758	K562	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	0.4652518999552602	[1057]	[1232]	3	hSpCas9	negative selection	694081
138694851	138694874	3	+	26627737	DLD1	viability	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	0.2896548466144928	[227]	[110,83,68]	3	hSpCas9	negative selection	819742
138707152	138707175	3	+	26627737	DLD1	viability	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	1.1659014583324026	[165]	[65,275,27]	9	hSpCas9	negative selection	819743
138712274	138712297	3	-	26627737	DLD1	viability	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	0.1313807444575837	[582]	[184,269,153]	1	hSpCas9	negative selection	819744
138714475	138714498	3	-	26627737	DLD1	viability	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.07342422560088432	[510]	[121,155,217]	0	hSpCas9	negative selection	819745
138755794	138755817	3	-	26627737	DLD1	viability	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.0365412392904072	[957]	[243,224,388]	0	hSpCas9	negative selection	819746
138759283	138759306	3	-	26627737	DLD1	viability	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	0.9542000463534648	[355]	[210,225,210]	8	hSpCas9	negative selection	819747
138694851	138694874	3	+	26627737	GBM cells	viability after 5 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-0.0048708098550112044	[115]	[65,57]	0	hSpCas9	negative selection	902057
138707152	138707175	3	+	26627737	GBM cells	viability after 5 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	0.08333844602311313	[153]	[82,91]	1	hSpCas9	negative selection	902058
138712274	138712297	3	-	26627737	GBM cells	viability after 5 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.26051875273898445	[410]	[221,145]	-4	hSpCas9	negative selection	902059
138714475	138714498	3	-	26627737	GBM cells	viability after 5 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.5249815789365146	[345]	[255,277]	7	hSpCas9	negative selection	902060
138755794	138755817	3	-	26627737	GBM cells	viability after 5 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.3603781292622914	[461]	[197,187]	-5	hSpCas9	negative selection	902061
138759283	138759306	3	-	26627737	GBM cells	viability after 5 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	0.054506401597377935	[280]	[158,153]	0	hSpCas9	negative selection	902062
138694851	138694874	3	+	26627737	GBM cells	viability after 13 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	0.14061899043999881	[115]	[75,63]	1	hSpCas9	negative selection	984372
138707152	138707175	3	+	26627737	GBM cells	viability after 13 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-0.01617695560876231	[153]	[91,74]	0	hSpCas9	negative selection	984373
138712274	138712297	3	-	26627737	GBM cells	viability after 13 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	0.1578744667433547	[410]	[309,198]	2	hSpCas9	negative selection	984374
138714475	138714498	3	-	26627737	GBM cells	viability after 13 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.6375537350224769	[345]	[403,200]	7	hSpCas9	negative selection	984375
138755794	138755817	3	-	26627737	GBM cells	viability after 13 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.058297993187376496	[461]	[280,207]	0	hSpCas9	negative selection	984376
138759283	138759306	3	-	26627737	GBM cells	viability after 13 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	0.35353756173497575	[280]	[137,240]	4	hSpCas9	negative selection	984377
138694851	138694874	3	+	26627737	GBM cells	viability after 21 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	0.11512687612233286	[115]	[73,62]	1	hSpCas9	negative selection	1066687
138707152	138707175	3	+	26627737	GBM cells	viability after 21 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	0.6910932989563581	[153]	[144,125]	7	hSpCas9	negative selection	1066688
138712274	138712297	3	-	26627737	GBM cells	viability after 21 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	0.5397579055945846	[410]	[333,315]	5	hSpCas9	negative selection	1066689
138714475	138714498	3	-	26627737	GBM cells	viability after 21 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.48397540370961717	[345]	[276,249]	5	hSpCas9	negative selection	1066690
138755794	138755817	3	-	26627737	GBM cells	viability after 21 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.660650542146895	[461]	[163,153]	-5	hSpCas9	negative selection	1066691
138759283	138759306	3	-	26627737	GBM cells	viability after 21 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	1.0379240688949878	[280]	[384,247]	8	hSpCas9	negative selection	1066692
138694851	138694874	3	+	26627737	RPE1	viability after 9 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-2.7187760351134265	[586]	[16,41]	-9	hSpCas9	negative selection	1149002
138707152	138707175	3	+	26627737	RPE1	viability after 9 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	0.16651514626481156	[189]	[40,99]	1	hSpCas9	negative selection	1149003
138712274	138712297	3	-	26627737	RPE1	viability after 9 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	0.3180729413293276	[725]	[209,377]	2	hSpCas9	negative selection	1149004
138714475	138714498	3	-	26627737	RPE1	viability after 9 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.6381757320245938	[707]	[299,402]	4	hSpCas9	negative selection	1149005
138755794	138755817	3	-	26627737	RPE1	viability after 9 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.9323258533144224	[1529]	[312,170]	-6	hSpCas9	negative selection	1149006
138759283	138759306	3	-	26627737	RPE1	viability after 9 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-0.5193123506695362	[939]	[86,357]	-4	hSpCas9	negative selection	1149007
138694851	138694874	3	+	26627737	RPE1	viability after 12 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-2.5943379433238114	[586]	[29,21]	-9	hSpCas9	negative selection	1231317
138707152	138707175	3	+	26627737	RPE1	viability after 12 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-0.7010515426535453	[189]	[27,34]	-5	hSpCas9	negative selection	1231318
138712274	138712297	3	-	26627737	RPE1	viability after 12 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	0.03593574943777622	[725]	[113,290]	0	hSpCas9	negative selection	1231319
138714475	138714498	3	-	26627737	RPE1	viability after 12 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	-0.12949853684023027	[707]	[135,213]	-1	hSpCas9	negative selection	1231320
138755794	138755817	3	-	26627737	RPE1	viability after 12 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.8398666807930978	[1529]	[234,223]	-5	hSpCas9	negative selection	1231321
138759283	138759306	3	-	26627737	RPE1	viability after 12 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-1.2297224721724718	[939]	[62,154]	-7	hSpCas9	negative selection	1231322
138694851	138694874	3	+	26627737	RPE1	viability after 15 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-4.228942338002785	[586]	[16,0]	-9	hSpCas9	negative selection	1313632
138707152	138707175	3	+	26627737	RPE1	viability after 15 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-0.47691837481650534	[189]	[31,44]	-3	hSpCas9	negative selection	1313633
138712274	138712297	3	-	26627737	RPE1	viability after 15 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.2223856312161061	[725]	[117,231]	-1	hSpCas9	negative selection	1313634
138714475	138714498	3	-	26627737	RPE1	viability after 15 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	-0.22848143557409084	[707]	[145,194]	-1	hSpCas9	negative selection	1313635
138755794	138755817	3	-	26627737	RPE1	viability after 15 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.3825571267825303	[1529]	[472,195]	-2	hSpCas9	negative selection	1313636
138759283	138759306	3	-	26627737	RPE1	viability after 15 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-1.210641037280628	[939]	[120,108]	-6	hSpCas9	negative selection	1313637
138694851	138694874	3	+	26627737	RPE1	viability after 18 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-3.1440954877292606	[586]	[0,35]	-9	hSpCas9	negative selection	1395947
138707152	138707175	3	+	26627737	RPE1	viability after 18 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-0.8589801143547997	[189]	[6,50]	-5	hSpCas9	negative selection	1395948
138712274	138712297	3	-	26627737	RPE1	viability after 18 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.34094743063614946	[725]	[28,288]	-2	hSpCas9	negative selection	1395949
138714475	138714498	3	-	26627737	RPE1	viability after 18 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	-0.7335773417848246	[707]	[53,179]	-4	hSpCas9	negative selection	1395950
138755794	138755817	3	-	26627737	RPE1	viability after 18 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-1.384223423666691	[1529]	[177,136]	-7	hSpCas9	negative selection	1395951
138759283	138759306	3	-	26627737	RPE1	viability after 18 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-2.2955103432231043	[939]	[12,92]	-8	hSpCas9	negative selection	1395952
138694851	138694874	3	+	26627737	HeLa	viability after 8 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	3.096146610737053	[28]	[173,81,83]	9	hSpCas9	negative selection	1478262
138707152	138707175	3	+	26627737	HeLa	viability after 8 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-0.06948867475508869	[238]	[34,145,101]	0	hSpCas9	negative selection	1478263
138712274	138712297	3	-	26627737	HeLa	viability after 8 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.02730253215592493	[648]	[284,358,194]	0	hSpCas9	negative selection	1478264
138714475	138714498	3	-	26627737	HeLa	viability after 8 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.8841470511290672	[460]	[508,287,345]	7	hSpCas9	negative selection	1478265
138755794	138755817	3	-	26627737	HeLa	viability after 8 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-1.0143633347385173	[935]	[251,236,131]	-8	hSpCas9	negative selection	1478266
138759283	138759306	3	-	26627737	HeLa	viability after 8 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-0.4464129544293615	[369]	[210,76,88]	-4	hSpCas9	negative selection	1478267
138694851	138694874	3	+	26627737	HeLa	viability after 12 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	2.8965501341496394	[28]	[152,56,62]	9	hSpCas9	negative selection	1560577
138707152	138707175	3	+	26627737	HeLa	viability after 12 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	0.17427751858579654	[238]	[117,59,161]	1	hSpCas9	negative selection	1560578
138712274	138712297	3	-	26627737	HeLa	viability after 12 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.19921349195684113	[648]	[307,195,202]	-2	hSpCas9	negative selection	1560579
138714475	138714498	3	-	26627737	HeLa	viability after 12 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.39480947625313345	[460]	[234,174,348]	3	hSpCas9	negative selection	1560580
138755794	138755817	3	-	26627737	HeLa	viability after 12 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.672590190001686	[935]	[425,198,112]	-6	hSpCas9	negative selection	1560581
138759283	138759306	3	-	26627737	HeLa	viability after 12 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-0.31390300710526525	[369]	[83,121,161]	-3	hSpCas9	negative selection	1560582
138694851	138694874	3	+	26627737	HeLa	viability after 15 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	2.987653929822027	[28]	[82,68,131]	9	hSpCas9	negative selection	1642892
138707152	138707175	3	+	26627737	HeLa	viability after 15 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-0.3910090299439706	[238]	[33,67,124]	-3	hSpCas9	negative selection	1642893
138712274	138712297	3	-	26627737	HeLa	viability after 15 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.12648340142757952	[648]	[346,192,179]	-1	hSpCas9	negative selection	1642894
138714475	138714498	3	-	26627737	HeLa	viability after 15 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.3732006268526279	[460]	[274,99,362]	3	hSpCas9	negative selection	1642895
138755794	138755817	3	-	26627737	HeLa	viability after 15 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.9344049214967638	[935]	[116,200,287]	-7	hSpCas9	negative selection	1642896
138759283	138759306	3	-	26627737	HeLa	viability after 15 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-0.15061918576914402	[369]	[166,75,165]	-1	hSpCas9	negative selection	1642897
138694851	138694874	3	+	26627737	HeLa	viability after 18 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	2.9442590169826284	[28]	[51,54,131]	9	hSpCas9	negative selection	1725207
138707152	138707175	3	+	26627737	HeLa	viability after 18 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-0.4404001011549521	[238]	[18,54,124]	-4	hSpCas9	negative selection	1725208
138712274	138712297	3	-	26627737	HeLa	viability after 18 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.15580839589810358	[648]	[231,148,179]	-1	hSpCas9	negative selection	1725209
138714475	138714498	3	-	26627737	HeLa	viability after 18 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.37027410081782963	[460]	[180,85,362]	3	hSpCas9	negative selection	1725210
138755794	138755817	3	-	26627737	HeLa	viability after 18 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.9738094801696429	[935]	[69,163,287]	-7	hSpCas9	negative selection	1725211
138759283	138759306	3	-	26627737	HeLa	viability after 18 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-0.1451395276797533	[369]	[112,62,165]	-1	hSpCas9	negative selection	1725212
138694851	138694874	3	+	26627737	HCT116	viability after 6 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-0.669240299512805	[382]	[62,23]	-4	hSpCas9	negative selection	1807522
138707152	138707175	3	+	26627737	HCT116	viability after 6 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	0.8680436843082198	[303]	[190,29]	5	hSpCas9	negative selection	1807523
138712274	138712297	3	-	26627737	HCT116	viability after 6 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	0.2102708639291364	[942]	[195,157]	1	hSpCas9	negative selection	1807524
138714475	138714498	3	-	26627737	HCT116	viability after 6 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.23907140610269717	[428]	[96,69]	1	hSpCas9	negative selection	1807525
138755794	138755817	3	-	26627737	HCT116	viability after 6 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.7105527297698269	[1065]	[55,127]	-4	hSpCas9	negative selection	1807526
138759283	138759306	3	-	26627737	HCT116	viability after 6 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-0.41370536407036285	[484]	[102,31]	-2	hSpCas9	negative selection	1807527
138694851	138694874	3	+	26627737	HCT116	viability after 8 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-0.7225177513778734	[164]	[89,26,48]	-7	hSpCas9	negative selection	1889837
138707152	138707175	3	+	26627737	HCT116	viability after 8 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	1.0339882928930018	[81]	[114,72,89]	8	hSpCas9	negative selection	1889838
138712274	138712297	3	-	26627737	HCT116	viability after 8 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.38407765043891706	[681]	[223,288,348]	-4	hSpCas9	negative selection	1889839
138714475	138714498	3	-	26627737	HCT116	viability after 8 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	-0.04866430559626411	[375]	[178,174,245]	0	hSpCas9	negative selection	1889840
138755794	138755817	3	-	26627737	HCT116	viability after 8 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.12361526278093538	[499]	[285,198,273]	-1	hSpCas9	negative selection	1889841
138759283	138759306	3	-	26627737	HCT116	viability after 8 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-0.4523693973468573	[187]	[69,78,77]	-5	hSpCas9	negative selection	1889842
138694851	138694874	3	+	26627737	HCT116	viability after 9 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-0.2622398463305271	[382]	[34,124]	-2	hSpCas9	negative selection	1972152
138707152	138707175	3	+	26627737	HCT116	viability after 9 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-1.1697670411441508	[303]	[20,47]	-7	hSpCas9	negative selection	1972153
138712274	138712297	3	-	26627737	HCT116	viability after 9 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-1.0375246939857714	[942]	[163,89]	-6	hSpCas9	negative selection	1972154
138714475	138714498	3	-	26627737	HCT116	viability after 9 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	-0.9040020568414293	[428]	[82,43]	-6	hSpCas9	negative selection	1972155
138755794	138755817	3	-	26627737	HCT116	viability after 9 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	0.2521395517306366	[1065]	[152,485]	2	hSpCas9	negative selection	1972156
138759283	138759306	3	-	26627737	HCT116	viability after 9 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	1.0782369713403483	[484]	[87,419]	7	hSpCas9	negative selection	1972157
138694851	138694874	3	+	26627737	HCT116	viability after 12 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-0.010602481513169004	[164]	[28,75,157]	0	hSpCas9	negative selection	2054467
138707152	138707175	3	+	26627737	HCT116	viability after 12 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	1.023113671745036	[81]	[42,101,121]	8	hSpCas9	negative selection	2054468
138712274	138712297	3	-	26627737	HCT116	viability after 12 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.8999598790601495	[681]	[137,275,168]	-7	hSpCas9	negative selection	2054469
138714475	138714498	3	-	26627737	HCT116	viability after 12 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.06694199565890369	[375]	[249,199,166]	0	hSpCas9	negative selection	2054470
138755794	138755817	3	-	26627737	HCT116	viability after 12 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	0.442712157467512	[499]	[364,244,457]	4	hSpCas9	negative selection	2054471
138759283	138759306	3	-	26627737	HCT116	viability after 12 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	0.2621905199485873	[187]	[59,175,125]	2	hSpCas9	negative selection	2054472
138694851	138694874	3	+	26627737	HCT116	viability after 15 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-0.4689492479693055	[164]	[46,105,49]	-5	hSpCas9	negative selection	2136782
138707152	138707175	3	+	26627737	HCT116	viability after 15 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	0.980790671231925	[81]	[113,42,123]	8	hSpCas9	negative selection	2136783
138712274	138712297	3	-	26627737	HCT116	viability after 15 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.11332070657944215	[681]	[328,206,543]	-1	hSpCas9	negative selection	2136784
138714475	138714498	3	-	26627737	HCT116	viability after 15 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.193641765148663	[375]	[336,99,313]	2	hSpCas9	negative selection	2136785
138755794	138755817	3	-	26627737	HCT116	viability after 15 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.09313300211330888	[499]	[245,308,249]	-1	hSpCas9	negative selection	2136786
138759283	138759306	3	-	26627737	HCT116	viability after 15 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-0.06348377755465073	[187]	[136,151,25]	0	hSpCas9	negative selection	2136787
138694851	138694874	3	+	26627737	HCT116	viability after 18 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-1.0491791991518706	[164]	[3,23,90]	-7	hSpCas9	negative selection	2219097
138707152	138707175	3	+	26627737	HCT116	viability after 18 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-0.05881097893216092	[81]	[42,28,42]	0	hSpCas9	negative selection	2219098
138712274	138712297	3	-	26627737	HCT116	viability after 18 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.21884582720753665	[681]	[278,155,429]	-2	hSpCas9	negative selection	2219099
138714475	138714498	3	-	26627737	HCT116	viability after 18 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.338727944048217	[375]	[278,240,165]	3	hSpCas9	negative selection	2219100
138755794	138755817	3	-	26627737	HCT116	viability after 18 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	0.3820821742154862	[499]	[300,269,379]	3	hSpCas9	negative selection	2219101
138759283	138759306	3	-	26627737	HCT116	viability after 18 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	0.2470582844869484	[187]	[207,88,23]	2	hSpCas9	negative selection	2219102
138698918	138698941	3	-	24336569	HL60	viability	AATCAAGTGGAATAAACTTGAGG	PIK3CB	ENSG00000051382	-0.16775920544123335	[1041]	[1962]	-1	hSpCas9	negative selection	2284116
138698931	138698954	3	-	24336569	HL60	viability	AATTACTGCTGTCAATCAAGTGG	PIK3CB	ENSG00000051382	0.9069582577741889	[562]	[2233]	7	hSpCas9	negative selection	2284117
138699044	138699067	3	-	24336569	HL60	viability	ATTGAAAGAAATCTTGGACAGGG	PIK3CB	ENSG00000051382	2.825426494979623	[1]	[29]	9	hSpCas9	negative selection	2284118
138699049	138699072	3	+	24336569	HL60	viability	TCCAAGATTTCTTTCAATACAGG	PIK3CB	ENSG00000051382	-0.6996761057000467	[405]	[528]	-6	hSpCas9	negative selection	2284119
138707147	138707170	3	+	24336569	HL60	viability	TAATTAGCTTACCTTATCGAAGG	PIK3CB	ENSG00000051382	0.8436975969858237	[271]	[1032]	7	hSpCas9	negative selection	2284120
138707152	138707175	3	+	24336569	HL60	viability	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	0.04889042951139044	[845]	[1851]	0	hSpCas9	negative selection	2284121
138707158	138707181	3	-	24336569	HL60	viability	TTATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	5.41838178645431	[1]	[180]	9	hSpCas9	negative selection	2284122
138707163	138707186	3	+	24336569	HL60	viability	TCGAAGGGAGGGTAATAATAAGG	PIK3CB	ENSG00000051382	0.8266134099300643	[161]	[607]	6	hSpCas9	negative selection	2284123
138707244	138707267	3	+	24336569	HL60	viability	TTTGTTTGAACAGTTCCCATTGG	PIK3CB	ENSG00000051382	-0.5544716685450704	[346]	[499]	-5	hSpCas9	negative selection	2284124
138707259	138707282	3	-	24336569	HL60	viability	GAAGAAATGTTGAATCCAATGGG	PIK3CB	ENSG00000051382	0.25719287661208223	[462]	[1170]	2	hSpCas9	negative selection	2284125
138698918	138698941	3	-	24336569	KBM7	viability	AATCAAGTGGAATAAACTTGAGG	PIK3CB	ENSG00000051382	-0.03273396688328911	[937]	[2500]	0	hSpCas9	negative selection	2351293
138698931	138698954	3	-	24336569	KBM7	viability	AATTACTGCTGTCAATCAAGTGG	PIK3CB	ENSG00000051382	0.06699397628087567	[601]	[1719]	0	hSpCas9	negative selection	2351294
138699044	138699067	3	-	24336569	KBM7	viability	ATTGAAAGAAATCTTGGACAGGG	PIK3CB	ENSG00000051382	5.901148957682196	[0]	[162]	9	hSpCas9	negative selection	2351295
138699049	138699072	3	+	24336569	KBM7	viability	TCCAAGATTTCTTTCAATACAGG	PIK3CB	ENSG00000051382	0.4399460741927048	[259]	[961]	4	hSpCas9	negative selection	2351296
138707147	138707170	3	+	24336569	KBM7	viability	TAATTAGCTTACCTTATCGAAGG	PIK3CB	ENSG00000051382	-0.5631988671943985	[421]	[778]	-4	hSpCas9	negative selection	2351297
138707152	138707175	3	+	24336569	KBM7	viability	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-0.3841841152603731	[767]	[1604]	-3	hSpCas9	negative selection	2351298
138707158	138707181	3	-	24336569	KBM7	viability	TTATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	0.7540546646207682	[69]	[321]	6	hSpCas9	negative selection	2351299
138707163	138707186	3	+	24336569	KBM7	viability	TCGAAGGGAGGGTAATAATAAGG	PIK3CB	ENSG00000051382	0.4100386280189645	[273]	[992]	4	hSpCas9	negative selection	2351300
138707244	138707267	3	+	24336569	KBM7	viability	TTTGTTTGAACAGTTCCCATTGG	PIK3CB	ENSG00000051382	-1.3027864123043906	[340]	[376]	-7	hSpCas9	negative selection	2351301
138707259	138707282	3	-	24336569	KBM7	viability	GAAGAAATGTTGAATCCAATGGG	PIK3CB	ENSG00000051382	0.2201011027171595	[417]	[1327]	2	hSpCas9	negative selection	2351302
138763332	138763355	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	TTTCACCATGTTGGTCAGGCTAG	PIK3CB	ENSG00000051382	-0.9950505910624323	[34,30]	[4,1]	-6	dCas9-VP64	positive selection	2385285
138827780	138827803	3	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTTCACCGTGTTAGCCAGGATAG	PIK3CB	ENSG00000051382	0.2955844688889684	[184,570]	[130,72]	1	dCas9-VP64	positive selection	2398466
138817107	138817130	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGCGGGCGGATCACGAGGTCTGG	PIK3CB	ENSG00000051382	3.672125698082768	[96,21]	[254,70]	9	dCas9-VP64	positive selection	2408033
138784689	138784712	3	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGTCTGCAATCCCAGCACCTCGG	PIK3CB	ENSG00000051382	4.45375407688863	[141,327]	[34,2339]	9	dCas9-VP64	positive selection	2408152
138821696	138821719	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	AATCGCTTGAACCTGGGAGGGAG	PIK3CB	ENSG00000051382	0.7552978455787054	[33,39]	[12,13]	3	dCas9-VP64	positive selection	2413258
138707773	138707796	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATACCTTCTCTGGTAGCCTCTGG	PIK3CB	ENSG00000051382	4.121003709906264	[49,116]	[46,621]	9	dCas9-VP64	positive selection	2415801
138707790	138707813	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	CTCTGGAATACTCCATTAAGTGG	PIK3CB	ENSG00000051382	-1.3209300200354364	[279,187]	[28,9]	-7	dCas9-VP64	positive selection	2415802
138707753	138707776	3	-	25494202	A375	resistance to PLX-4720 (puromycin)	TATTTTCTGTCAGCAGTTGCAGG	PIK3CB	ENSG00000051382	0.6543771542586785	[34,47]	[24,1]	3	dCas9-VP64	positive selection	2415803
138759462	138759485	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATAGCCAATAATGTAACAGGAGG	PIK3CB	ENSG00000051382	-0.08641527542023397	[28,66]	[11,6]	0	dCas9-VP64	positive selection	2439674
138759513	138759536	3	-	25494202	A375	resistance to PLX-4720 (puromycin)	TATTTCTGCTGACTTACTCTTGG	PIK3CB	ENSG00000051382	-1.6411944408938177	[813,377]	[44,37]	-8	dCas9-VP64	positive selection	2439675
138759466	138759489	3	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTGGCCTCCTGTTACATTATTGG	PIK3CB	ENSG00000051382	-0.4529862304194061	[523,260]	[66,57]	-2	dCas9-VP64	positive selection	2439676
138665818	138665841	3	-	25494202	A375	resistance to PLX-4720 (puromycin)	CCCAGCACTTTGGGAGGCTGGGG	PIK3CB	ENSG00000051382	0.17430442440476024	[13,29]	[6,2]	0	dCas9-VP64	positive selection	2446192
138819712	138819735	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACCTGTAATCCCAACGCTTTAG	PIK3CB	ENSG00000051382	1.2349516175358481	[176,305]	[87,165]	5	dCas9-VP64	positive selection	2448560
138727931	138727954	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACTGCAACCTCCGCCTCCCAGG	PIK3CB	ENSG00000051382	0.6259309833286419	[228,309]	[35,151]	2	dCas9-VP64	positive selection	2450524
138817243	138817266	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGAGAATGGCATGAACCCCGG	PIK3CB	ENSG00000051382	-0.6383309141464126	[28,8]	[1,1]	-3	dCas9-VP64	positive selection	2452443
138711038	138711061	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACACCACTGCACTCCAGCCGAG	PIK3CB	ENSG00000051382	-0.6897978744123147	[436,52]	[50,12]	-4	dCas9-VP64	positive selection	2457764
138822440	138822463	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGGAGGCTGAGGCAGGAGAACAG	PIK3CB	ENSG00000051382	1.7244712313844854	[32,17]	[27,7]	6	dCas9-VP64	positive selection	2468543
138753760	138753783	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	CGCACCACTGCACTCCAGCCTAG	PIK3CB	ENSG00000051382	3.0347564003538725	[8,6]	[27,0]	8	dCas9-VP64	positive selection	2470763
138761895	138761918	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	ACGCCACTGCACTCCAGCCTGGG	PIK3CB	ENSG00000051382	0.6631647882125523	[138,30]	[44,11]	3	dCas9-VP64	positive selection	2473769
138746543	138746566	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCCAGCTCCTCGGGAGGCTGAGG	PIK3CB	ENSG00000051382	-0.2571104693801929	[13,2]	[1,0]	-1	dCas9-VP64	positive selection	2474860
138763332	138763355	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	TTTCACCATGTTGGTCAGGCTAG	PIK3CB	ENSG00000051382	-0.9351084987288634	[176,47]	[27,9]	-8	dCas9-VP64	positive selection	2480540
138827780	138827803	3	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTTCACCGTGTTAGCCAGGATAG	PIK3CB	ENSG00000051382	1.071805523628855	[383,191]	[227,172]	7	dCas9-VP64	positive selection	2493721
138817107	138817130	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGCGGGCGGATCACGAGGTCTGG	PIK3CB	ENSG00000051382	2.475771989876751	[78,50]	[99,137]	9	dCas9-VP64	positive selection	2503288
138784689	138784712	3	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGTCTGCAATCCCAGCACCTCGG	PIK3CB	ENSG00000051382	-1.0967727414741575	[288,207]	[42,31]	-9	dCas9-VP64	positive selection	2503407
138821696	138821719	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	AATCGCTTGAACCTGGGAGGGAG	PIK3CB	ENSG00000051382	1.0802526276452251	[21,53]	[11,38]	7	dCas9-VP64	positive selection	2508513
138707773	138707796	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATACCTTCTCTGGTAGCCTCTGG	PIK3CB	ENSG00000051382	0.030997746316952846	[488,451]	[183,131]	0	dCas9-VP64	positive selection	2511056
138707790	138707813	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	CTCTGGAATACTCCATTAAGTGG	PIK3CB	ENSG00000051382	3.4753711949104864	[421,233]	[2420,57]	9	dCas9-VP64	positive selection	2511057
138707753	138707776	3	-	25494202	A375	resistance to PLX-4720 (zeocin)	TATTTTCTGTCAGCAGTTGCAGG	PIK3CB	ENSG00000051382	0.171288130268634	[141,88]	[68,17]	1	dCas9-VP64	positive selection	2511058
138759462	138759485	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATAGCCAATAATGTAACAGGAGG	PIK3CB	ENSG00000051382	0.7082393086225893	[88,89]	[44,49]	5	dCas9-VP64	positive selection	2534929
138759513	138759536	3	-	25494202	A375	resistance to PLX-4720 (zeocin)	TATTTCTGCTGACTTACTCTTGG	PIK3CB	ENSG00000051382	0.7104150125860498	[473,544]	[202,336]	5	dCas9-VP64	positive selection	2534930
138759466	138759489	3	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTGGCCTCCTGTTACATTATTGG	PIK3CB	ENSG00000051382	0.5520791961039995	[326,177]	[192,54]	4	dCas9-VP64	positive selection	2534931
138665818	138665841	3	-	25494202	A375	resistance to PLX-4720 (zeocin)	CCCAGCACTTTGGGAGGCTGGGG	PIK3CB	ENSG00000051382	-0.20184825873935663	[30,89]	[7,24]	-2	dCas9-VP64	positive selection	2541447
138819712	138819735	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACCTGTAATCCCAACGCTTTAG	PIK3CB	ENSG00000051382	0.26380133704388253	[158,443]	[162,74]	2	dCas9-VP64	positive selection	2543815
138727931	138727954	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACTGCAACCTCCGCCTCCCAGG	PIK3CB	ENSG00000051382	0.8832307312434098	[227,267]	[69,222]	6	dCas9-VP64	positive selection	2545779
138817243	138817266	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGAGAATGGCATGAACCCCGG	PIK3CB	ENSG00000051382	4.9253728466972815	[108,193]	[3088,18]	9	dCas9-VP64	positive selection	2547698
138711038	138711061	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACACCACTGCACTCCAGCCGAG	PIK3CB	ENSG00000051382	0.2274396231328648	[285,212]	[141,51]	1	dCas9-VP64	positive selection	2553019
138822440	138822463	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGGAGGCTGAGGCAGGAGAACAG	PIK3CB	ENSG00000051382	-0.1093774260535414	[64,117]	[17,35]	-1	dCas9-VP64	positive selection	2563798
138753760	138753783	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	CGCACCACTGCACTCCAGCCTAG	PIK3CB	ENSG00000051382	0.038175304513698105	[60,77]	[26,18]	0	dCas9-VP64	positive selection	2566018
138761895	138761918	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	ACGCCACTGCACTCCAGCCTGGG	PIK3CB	ENSG00000051382	-0.07877572482445189	[107,69]	[28,25]	0	dCas9-VP64	positive selection	2569024
138746543	138746566	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCCAGCTCCTCGGGAGGCTGAGG	PIK3CB	ENSG00000051382	0.5230605474514848	[120,26]	[20,47]	4	dCas9-VP64	positive selection	2570115
138712189	138712212	3	+	27013184	SW480	treatment with recombinant TRAIL	ATAAGAATGTAAATCTTACCAGG	PIK3CB	ENSG00000051382	-5.57081327377721	[330,229]	[2,1]	-9	hSpCas9	positive selection	2954557
138712276	138712299	3	+	27013184	SW480	treatment with recombinant TRAIL	ATCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	-2.9970205762416895	[309,413]	[8,33]	-8	hSpCas9	positive selection	2954558
138759213	138759236	3	+	27013184	SW480	treatment with recombinant TRAIL	AACTGGATATAAATCCCAGTGGG	PIK3CB	ENSG00000051382	0.4780699996247899	[68,132]	[58,58]	2	hSpCas9	positive selection	2954559
138759220	138759243	3	+	27013184	SW480	treatment with recombinant TRAIL	TATAAATCCCAGTGGGCAAAAGG	PIK3CB	ENSG00000051382	-1.2052097324355282	[41,113]	[13,13]	-5	hSpCas9	positive selection	2954560
138759236	138759259	3	+	27013184	SW480	treatment with recombinant TRAIL	CAAAAGGAAATCCACAGGTATGG	PIK3CB	ENSG00000051382	-2.3084477263384082	[1,47]	[1,1]	-8	hSpCas9	positive selection	2954561
138759280	138759303	3	+	27013184	SW480	treatment with recombinant TRAIL	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.5858333435301206	[146,187]	[26,76]	-3	hSpCas9	positive selection	2954562
138759297	138759320	3	+	27013184	SW480	treatment with recombinant TRAIL	TCAAGGATGTCTGCCATAGCAGG	PIK3CB	ENSG00000051382	-2.4513098548586387	[100,130]	[13,1]	-8	hSpCas9	positive selection	2954563
138759300	138759323	3	+	27013184	SW480	treatment with recombinant TRAIL	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	-4.235379467325857	[221,415]	[9,2]	-9	hSpCas9	positive selection	2954564
138759333	138759356	3	+	27013184	SW480	treatment with recombinant TRAIL	CTGAAGCACATTCATAACCACGG	PIK3CB	ENSG00000051382	0.4958274305899532	[176,250]	[159,82]	2	hSpCas9	positive selection	2954565
138759334	138759357	3	+	27013184	SW480	treatment with recombinant TRAIL	TGAAGCACATTCATAACCACGGG	PIK3CB	ENSG00000051382	0.8081222897456691	[136,182]	[120,116]	4	hSpCas9	positive selection	2954566
138759335	138759358	3	+	27013184	SW480	treatment with recombinant TRAIL	GAAGCACATTCATAACCACGGGG	PIK3CB	ENSG00000051382	0.7280360768003625	[195,253]	[191,111]	3	hSpCas9	positive selection	2954567
138759172	138759195	3	-	27013184	SW480	treatment with recombinant TRAIL	TACCATTTCTTATATTAAGCAGG	PIK3CB	ENSG00000051382	-0.9165817256310651	[151,92]	[21,37]	-4	hSpCas9	positive selection	2954568
138759199	138759222	3	-	27013184	SW480	treatment with recombinant TRAIL	TATCCAGTTGGAGGTACCTCGGG	PIK3CB	ENSG00000051382	1.0329241101145923	[79,90]	[98,40]	5	hSpCas9	positive selection	2954569
138759200	138759223	3	-	27013184	SW480	treatment with recombinant TRAIL	ATATCCAGTTGGAGGTACCTCGG	PIK3CB	ENSG00000051382	0.4903053132517443	[270,284]	[104,257]	2	hSpCas9	positive selection	2954570
138759211	138759234	3	-	27013184	SW480	treatment with recombinant TRAIL	CACTGGGATTTATATCCAGTTGG	PIK3CB	ENSG00000051382	2.2008061750728922	[180,78]	[263,270]	8	hSpCas9	positive selection	2954571
138759247	138759270	3	-	27013184	SW480	treatment with recombinant TRAIL	ATCTGATGGCTCCATACCTGTGG	PIK3CB	ENSG00000051382	0.16385477588035657	[730,314]	[132,444]	0	hSpCas9	positive selection	2954572
138714483	138714506	3	+	27013184	SW480	treatment with recombinant TRAIL	CCTGATGGTCTGATATTTAGAGG	PIK3CB	ENSG00000051382	-1.1498917762478118	[76,175]	[31,11]	-5	hSpCas9	positive selection	2954573
138759261	138759284	3	-	27013184	SW480	treatment with recombinant TRAIL	GATTCACAGATAGCATCTGATGG	PIK3CB	ENSG00000051382	-1.3438155044306672	[16,50]	[7,1]	-6	hSpCas9	positive selection	2954574
138759283	138759306	3	-	27013184	SW480	treatment with recombinant TRAIL	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-3.5068745370210133	[138,44]	[1,5]	-9	hSpCas9	positive selection	2954575
138759286	138759309	3	-	27013184	SW480	treatment with recombinant TRAIL	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	-1.025663516025288	[286,376]	[97,28]	-4	hSpCas9	positive selection	2954576
138759289	138759312	3	-	27013184	SW480	treatment with recombinant TRAIL	GGCAGACATCCTTGACATCTGGG	PIK3CB	ENSG00000051382	3.147180455661646	[34,18]	[107,102]	9	hSpCas9	positive selection	2954577
138759290	138759313	3	-	27013184	SW480	treatment with recombinant TRAIL	TGGCAGACATCCTTGACATCTGG	PIK3CB	ENSG00000051382	0.798071443201569	[308,249]	[117,344]	4	hSpCas9	positive selection	2954578
138759310	138759333	3	-	27013184	SW480	treatment with recombinant TRAIL	TTTCATAATGCCTCCTGCTATGG	PIK3CB	ENSG00000051382	0.9302953004079031	[220,133]	[189,90]	4	hSpCas9	positive selection	2954579
138712221	138712244	3	-	27013184	SW480	treatment with recombinant TRAIL	GAGACATAATATTACACAGCTGG	PIK3CB	ENSG00000051382	1.2124738110114626	[1,1]	[1,1]	6	hSpCas9	positive selection	2954580
138712286	138712309	3	-	27013184	SW480	treatment with recombinant TRAIL	ACAGCATTATCCTGTAGCGTGGG	PIK3CB	ENSG00000051382	1.0195487522818625	[496,724]	[438,648]	5	hSpCas9	positive selection	2954581
138712287	138712310	3	-	27013184	SW480	treatment with recombinant TRAIL	AACAGCATTATCCTGTAGCGTGG	PIK3CB	ENSG00000051382	0.650630502654008	[129,241]	[179,40]	3	hSpCas9	positive selection	2954582
138759170	138759193	3	+	27013184	SW480	treatment with recombinant TRAIL	TACCTGCTTAATATAAGAAATGG	PIK3CB	ENSG00000051382	-2.448133743052587	[54,54]	[5,1]	-8	hSpCas9	positive selection	2954583
138759183	138759206	3	+	27013184	SW480	treatment with recombinant TRAIL	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	0.17550136144202066	[80,75]	[58,8]	0	hSpCas9	positive selection	2954584
138759196	138759219	3	+	27013184	SW480	treatment with recombinant TRAIL	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.7053745246536257	[204,161]	[108,160]	3	hSpCas9	positive selection	2954585
138759212	138759235	3	+	27013184	SW480	treatment with recombinant TRAIL	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	1.060094724114423	[67,174]	[135,60]	5	hSpCas9	positive selection	2954586
138742707	138742730	3	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AAAAATGCGCAAATTCAGCGAGG	PIK3CB	ENSG00000051382	0.05684515940484397	[2,2]	[2,2]	1	hSpCas9	positive selection	3011371
138759286	138759309	3	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.018505664255035456	[3,3]	[4,2]	0	hSpCas9	positive selection	3011372
138714599	138714622	3	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ATATTAATATCAAATTCCAGTGG	PIK3CB	ENSG00000051382	0.5172615792262676	[3,3]	[4,4]	9	hSpCas9	positive selection	3011373
138714649	138714672	3	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGATACCTCTGAGCTTACGATGG	PIK3CB	ENSG00000051382	0.478421268273163	[2,2]	[1,4]	8	hSpCas9	positive selection	3011374
138742707	138742730	3	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AAAAATGCGCAAATTCAGCGAGG	PIK3CB	ENSG00000051382	0.18375927097172795	[2,2]	[2,1]	3	hSpCas9	positive selection	3079229
138759286	138759309	3	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	-0.1896241991855092	[3,3]	[3,1]	-3	hSpCas9	positive selection	3079230
138714599	138714622	3	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ATATTAATATCAAATTCCAGTGG	PIK3CB	ENSG00000051382	0.6338003243163695	[3,3]	[4,4]	9	hSpCas9	positive selection	3079231
138714649	138714672	3	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGATACCTCTGAGCTTACGATGG	PIK3CB	ENSG00000051382	-0.03702275677068384	[2,2]	[0,1]	0	hSpCas9	positive selection	3079232
138759280	138759303		+	24336571	A375	resistance to PLX after 7 days	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.14554931396187332	[30,32]	[29,27]	-5	hSpCas9	positive selection	3135626
138759200	138759223		-	24336571	A375	resistance to PLX after 7 days	ATATCCAGTTGGAGGTACCTCGG	PIK3CB	ENSG00000051382	0.20596504993173897	[14,16]	[19,16]	6	hSpCas9	positive selection	3135627
138755810	138755833		+	24336571	A375	resistance to PLX after 7 days	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.3993060249482706	[7,4]	[3,4]	-9	hSpCas9	positive selection	3135628
138755795	138755818		-	24336571	A375	resistance to PLX after 7 days	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.05306815675031862	[7,6]	[7,6]	-1	hSpCas9	positive selection	3135629
138759172	138759195		-	24336571	A375	resistance to PLX after 7 days	TACCATTTCTTATATTAAGCAGG	PIK3CB	ENSG00000051382	-0.112278747478334	[2,3]	[2,3]	-3	hSpCas9	positive selection	3135630
138755930	138755953		+	24336571	A375	resistance to PLX after 7 days	TCCATAAGGAGGTTGAACATTGG	PIK3CB	ENSG00000051382	-0.19971957637124926	[8,10]	[6,8]	-6	hSpCas9	positive selection	3135632
138759280	138759303		+	24336571	A375	resistance to PLX after 14 days	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.2785092207054365	[27,34]	[10,12]	-3	hSpCas9	positive selection	3193419
138759200	138759223		-	24336571	A375	resistance to PLX after 14 days	ATATCCAGTTGGAGGTACCTCGG	PIK3CB	ENSG00000051382	1.617275634780542	[12,14]	[18,22]	9	hSpCas9	positive selection	3193420
138755810	138755833		+	24336571	A375	resistance to PLX after 14 days	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.030290517672006967	[4,3]	[1,1]	0	hSpCas9	positive selection	3193421
138755795	138755818		-	24336571	A375	resistance to PLX after 14 days	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.6761209692190978	[8,4]	[5,4]	6	hSpCas9	positive selection	3193422
138759172	138759195		-	24336571	A375	resistance to PLX after 14 days	TACCATTTCTTATATTAAGCAGG	PIK3CB	ENSG00000051382	-0.0014826637891827144	[3,4]	[1,1]	0	hSpCas9	positive selection	3193423
138755930	138755953		+	24336571	A375	resistance to PLX after 14 days	TCCATAAGGAGGTTGAACATTGG	PIK3CB	ENSG00000051382	-0.4113584141313243	[6,10]	[1,2]	-5	hSpCas9	positive selection	3193425
138759280	138759303		+	24336571	A375	viability after 7 days	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.3522687214088549	[25]	[30,32]	5	hSpCas9	negative selection	3251212
138759200	138759223		-	24336571	A375	viability after 7 days	ATATCCAGTTGGAGGTACCTCGG	PIK3CB	ENSG00000051382	-0.013106233177628324	[16]	[14,16]	0	hSpCas9	negative selection	3251213
138755810	138755833		+	24336571	A375	viability after 7 days	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.09170422947748291	[5]	[7,4]	1	hSpCas9	negative selection	3251214
138755795	138755818		-	24336571	A375	viability after 7 days	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.4408489182075577	[10]	[7,6]	-6	hSpCas9	negative selection	3251215
138759172	138759195		-	24336571	A375	viability after 7 days	TACCATTTCTTATATTAAGCAGG	PIK3CB	ENSG00000051382	-1.3419348571687624	[10]	[2,3]	-9	hSpCas9	negative selection	3251216
138755930	138755953		+	24336571	A375	viability after 7 days	TCCATAAGGAGGTTGAACATTGG	PIK3CB	ENSG00000051382	0.25447708555334025	[8]	[8,10]	4	hSpCas9	negative selection	3251218
138759280	138759303		+	24336571	A375	viability after 14 days	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.3456868307179206	[25]	[27,34]	4	hSpCas9	negative selection	3309005
138759200	138759223		-	24336571	A375	viability after 14 days	ATATCCAGTTGGAGGTACCTCGG	PIK3CB	ENSG00000051382	-0.16516619560315315	[16]	[12,14]	-2	hSpCas9	negative selection	3309006
138755810	138755833		+	24336571	A375	viability after 14 days	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.31273344762771593	[5]	[4,3]	-4	hSpCas9	negative selection	3309007
138755795	138755818		-	24336571	A375	viability after 14 days	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.5715706945704642	[10]	[8,4]	-6	hSpCas9	negative selection	3309008
138759172	138759195		-	24336571	A375	viability after 14 days	TACCATTTCTTATATTAAGCAGG	PIK3CB	ENSG00000051382	-1.1752033909817425	[10]	[3,4]	-9	hSpCas9	negative selection	3309009
138755930	138755953		+	24336571	A375	viability after 14 days	TCCATAAGGAGGTTGAACATTGG	PIK3CB	ENSG00000051382	0.13702056653947808	[8]	[6,10]	1	hSpCas9	negative selection	3309011
138755810	138755833	3	+	27383988	293T	resistance to West Nile virus (flavivirus)	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.9905396707509337	[76,76]	[0,0]	4	hSpCas9	positive selection	3385882
138737753	138737776	3	-	27383988	293T	resistance to West Nile virus (flavivirus)	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.274055249070477	[184,184]	[0,0]	-2	hSpCas9	positive selection	3385883
138737702	138737725	3	+	27383988	293T	resistance to West Nile virus (flavivirus)	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.6253168379160062	[235,235]	[0,0]	-4	hSpCas9	positive selection	3385884
138742707	138742730	3	-	26780180	HT29	viability (Avana library 4 designs)	AAAAATGCGCAAATTCAGCGAGG	PIK3CB	ENSG00000051382	1.47365394343391	[]	[]	6	hSpCas9	negative selection	3449454
138759286	138759309	3	-	26780180	HT29	viability (Avana library 4 designs)	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.276481692120516	[]	[]	1	hSpCas9	negative selection	3449455
138714598	138714621	3	+	26780180	HT29	viability (Avana library 4 designs)	ATATTAATATCAAATTCCAGTGG	PIK3CB	ENSG00000051382	2.27287430408724	[]	[]	7	hSpCas9	negative selection	3449456
138714648	138714671	3	+	26780180	HT29	viability (Avana library 4 designs)	TGATACCTCTGAGCTTACGATGG	PIK3CB	ENSG00000051382	1.74214381561634	[]	[]	6	hSpCas9	negative selection	3449457
138759286	138759309	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	3.70147744685119	[]	[]	6	hSpCas9	negative selection	3544225
138742707	138742730	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	AAAAATGCGCAAATTCAGCGAGG	PIK3CB	ENSG00000051382	0.78656945396859	[]	[]	1	hSpCas9	negative selection	3544226
138714648	138714671	3	+	26780180	A375	viability (Avana lentiCRISPRv2)	TGATACCTCTGAGCTTACGATGG	PIK3CB	ENSG00000051382	-7.66483595501854	[]	[]	-7	hSpCas9	negative selection	3544227
138714598	138714621	3	+	26780180	A375	viability (Avana lentiCRISPRv2)	ATATTAATATCAAATTCCAGTGG	PIK3CB	ENSG00000051382	-21.5763780152161	[]	[]	-9	hSpCas9	negative selection	3544228
138737753	138737776	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	0.998888332900362	[]	[]	1	hSpCas9	negative selection	3544229
138714484	138714507	3	+	26780180	A375	viability (Avana lentiCRISPRv2)	CTGATGGTCTGATATTTAGAGGG	PIK3CB	ENSG00000051382	-2.27001860432241	[]	[]	-3	hSpCas9	negative selection	3544230
138759286	138759309	3	-	26780180	A375	viability (Avana lentiGuide)	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	-0.26366992979304	[]	[]	0	hSpCas9	negative selection	3652884
138742707	138742730	3	-	26780180	A375	viability (Avana lentiGuide)	AAAAATGCGCAAATTCAGCGAGG	PIK3CB	ENSG00000051382	-4.28239108561822	[]	[]	-7	hSpCas9	negative selection	3652885
138714648	138714671	3	+	26780180	A375	viability (Avana lentiGuide)	TGATACCTCTGAGCTTACGATGG	PIK3CB	ENSG00000051382	24.1376816294216	[]	[]	9	hSpCas9	negative selection	3652886
138714598	138714621	3	+	26780180	A375	viability (Avana lentiGuide)	ATATTAATATCAAATTCCAGTGG	PIK3CB	ENSG00000051382	-0.843529532939457	[]	[]	-1	hSpCas9	negative selection	3652887
138737753	138737776	3	-	26780180	A375	viability (Avana lentiGuide)	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	5.43239315343925	[]	[]	5	hSpCas9	negative selection	3652888
138714484	138714507	3	+	26780180	A375	viability (Avana lentiGuide)	CTGATGGTCTGATATTTAGAGGG	PIK3CB	ENSG00000051382	-4.93763331784388	[]	[]	-8	hSpCas9	negative selection	3652889
138759286	138759309	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.002838538724524192	[5]	[5,4]	0	hSpCas9	positive selection	3761543
138742707	138742730	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AAAAATGCGCAAATTCAGCGAGG	PIK3CB	ENSG00000051382	-0.2313022467762476	[4]	[5,2]	-4	hSpCas9	positive selection	3761544
138714648	138714671	3	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGATACCTCTGAGCTTACGATGG	PIK3CB	ENSG00000051382	-1.0886239674545723	[4]	[1,1]	-9	hSpCas9	positive selection	3761545
138714598	138714621	3	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATATTAATATCAAATTCCAGTGG	PIK3CB	ENSG00000051382	-1.5641062750669898	[8]	[2,1]	-9	hSpCas9	positive selection	3761546
138737753	138737776	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	0.08316719879271267	[5]	[6,5]	2	hSpCas9	positive selection	3761547
138714484	138714507	3	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTGATGGTCTGATATTTAGAGGG	PIK3CB	ENSG00000051382	-0.15799575965802026	[6]	[5,5]	-3	hSpCas9	positive selection	3761548
138759286	138759309	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.2919284931603937	[5]	[6,5]	7	hSpCas9	positive selection	3870150
138742707	138742730	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AAAAATGCGCAAATTCAGCGAGG	PIK3CB	ENSG00000051382	-0.5489448263560633	[4]	[1,3]	-6	hSpCas9	positive selection	3870151
138714648	138714671	3	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGATACCTCTGAGCTTACGATGG	PIK3CB	ENSG00000051382	-0.8729965312963986	[4]	[1,1]	-8	hSpCas9	positive selection	3870152
138714598	138714621	3	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATATTAATATCAAATTCCAGTGG	PIK3CB	ENSG00000051382	-0.009011702028655515	[5]	[5,3]	0	hSpCas9	positive selection	3870153
138737753	138737776	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	0.13603938810488925	[5]	[4,6]	3	hSpCas9	positive selection	3870154
138714484	138714507	3	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTGATGGTCTGATATTTAGAGGG	PIK3CB	ENSG00000051382	0.3359806477998787	[5]	[6,6]	8	hSpCas9	positive selection	3870155
138759280	138759303	3	+	26780180	A375	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	1.3412097016739	[]	[]	7	hSpCas9	negative selection	3980957
138737702	138737725	3	+	26780180	A375	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	1.85938362056194	[]	[]	9	hSpCas9	negative selection	3980958
138759196	138759219	3	+	26780180	A375	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	1.2591162575472	[]	[]	6	hSpCas9	negative selection	3980959
138755810	138755833	3	+	26780180	A375	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	1.31950306711903	[]	[]	7	hSpCas9	negative selection	3980960
138737753	138737776	3	-	26780180	A375	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	1.43715251193684	[]	[]	8	hSpCas9	negative selection	3980961
138755795	138755818	3	-	26780180	A375	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	2.28963004712973	[]	[]	9	hSpCas9	negative selection	3980962
138759280	138759303	3	+	26780180	HT29	viability (GeCKOv2 library)	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.901007682119614	[]	[]	4	hSpCas9	negative selection	4088923
138737702	138737725	3	+	26780180	HT29	viability (GeCKOv2 library)	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	2.12488372298992	[]	[]	9	hSpCas9	negative selection	4088924
138759196	138759219	3	+	26780180	HT29	viability (GeCKOv2 library)	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.653663919234904	[]	[]	2	hSpCas9	negative selection	4088925
138755810	138755833	3	+	26780180	HT29	viability (GeCKOv2 library)	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.715709285587649	[]	[]	2	hSpCas9	negative selection	4088926
138737753	138737776	3	-	26780180	HT29	viability (GeCKOv2 library)	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	1.10309645400244	[]	[]	5	hSpCas9	negative selection	4088927
138755795	138755818	3	-	26780180	HT29	viability (GeCKOv2 library)	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	2.30387802113663	[]	[]	9	hSpCas9	negative selection	4088928
138759280	138759303	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.13750908199434742	[4]	[3,3]	3	hSpCas9	positive selection	4160579
138759200	138759223	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ATATCCAGTTGGAGGTACCTCGG	PIK3CB	ENSG00000051382	0.45928237200024535	[3]	[2,4]	8	hSpCas9	positive selection	4160580
138755810	138755833	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.5082028075153097	[2]	[1,0]	-8	hSpCas9	positive selection	4160581
138755795	138755818	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.23663968600032864	[2]	[2,2]	6	hSpCas9	positive selection	4160582
138759172	138759195	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TACCATTTCTTATATTAAGCAGG	PIK3CB	ENSG00000051382	-0.10861715997857513	[2]	[1,0]	-3	hSpCas9	positive selection	4160583
138755930	138755953	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TCCATAAGGAGGTTGAACATTGG	PIK3CB	ENSG00000051382	0.1569571822602258	[2]	[2,1]	4	hSpCas9	positive selection	4160585
138759280	138759303	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.2764081172818408	[5]	[2,4,0,0]	-4	hSpCas9	positive selection	4224601
138759200	138759223	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ATATCCAGTTGGAGGTACCTCGG	PIK3CB	ENSG00000051382	0.4815691534783314	[3]	[4,2,5,0]	3	hSpCas9	positive selection	4224602
138755810	138755833	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.17504942377377047	[3]	[3,0,0,0]	-3	hSpCas9	positive selection	4224603
138755795	138755818	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.20887189479438045	[2]	[4,0,0,0]	1	hSpCas9	positive selection	4224604
138759172	138759195	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TACCATTTCTTATATTAAGCAGG	PIK3CB	ENSG00000051382	0.7974126925675769	[3]	[0,0,1,3]	5	hSpCas9	positive selection	4224605
138755930	138755953	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TCCATAAGGAGGTTGAACATTGG	PIK3CB	ENSG00000051382	0.34146333021347414	[3]	[0,0,0,2]	2	hSpCas9	positive selection	4224607
138759196	138759219	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.6564261625961175	[1]	[2,1]	9	hSpCas9	positive selection	4290285
138759280	138759303	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.015152911139718284	[3]	[3,2]	0	hSpCas9	positive selection	4290286
138755795	138755818	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.44629659844651026	[3]	[2,1]	-7	hSpCas9	positive selection	4290287
138755810	138755833	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.20331003590660168	[1]	[2,1]	4	hSpCas9	positive selection	4354537
138737753	138737776	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.09315989907957846	[3]	[3,1]	-2	hSpCas9	positive selection	4354538
138737702	138737725	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.4880655363225649	[3]	[2,0]	-8	hSpCas9	positive selection	4354539
138707158	138707180	3	-	27760321	OCIAML3	viability	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	-2.0525518147592177	[150,158]	[21,38]	-9	hSpCas9	negative selection	4427846
138712277	138712299	3	+	27760321	OCIAML3	viability	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	-1.5464142324139558	[239,188]	[40,77]	-8	hSpCas9	negative selection	4427847
138714660	138714682	3	+	27760321	OCIAML3	viability	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	-0.47663717721634136	[178,187]	[94,114]	-5	hSpCas9	negative selection	4427848
138737761	138737783	3	+	27760321	OCIAML3	viability	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	1.6577644640365956	[29,18]	[72,41]	9	hSpCas9	negative selection	4427849
138755920	138755942	3	+	27760321	OCIAML3	viability	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	-1.8644948536081398	[108,82]	[6,37]	-9	hSpCas9	negative selection	4427850
138707158	138707180	3	-	27760321	OCIAML2	viability	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	-0.4384334651188908	[150,158]	[67,125]	-5	hSpCas9	negative selection	4511309
138712277	138712299	3	+	27760321	OCIAML2	viability	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	-0.2697366721711876	[239,188]	[142,142]	-3	hSpCas9	negative selection	4511310
138714660	138714682	3	+	27760321	OCIAML2	viability	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	-0.24326861350941864	[178,187]	[135,112]	-3	hSpCas9	negative selection	4511311
138737761	138737783	3	+	27760321	OCIAML2	viability	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	-0.13903382648282214	[29,18]	[15,19]	-2	hSpCas9	negative selection	4511312
138755920	138755942	3	+	27760321	OCIAML2	viability	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	0.5894423796352555	[108,82]	[124,103]	7	hSpCas9	negative selection	4511313
138707158	138707180	3	-	27760321	MV411	viability	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	-0.5557563644374146	[150,158]	[21,141]	-4	hSpCas9	negative selection	4594772
138712277	138712299	3	+	27760321	MV411	viability	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	0.9718906105942939	[239,188]	[79,569]	7	hSpCas9	negative selection	4594773
138714660	138714682	3	+	27760321	MV411	viability	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	-0.5700567061102013	[178,187]	[79,84]	-4	hSpCas9	negative selection	4594774
138737761	138737783	3	+	27760321	MV411	viability	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	0.5294007612395002	[29,18]	[0,55]	4	hSpCas9	negative selection	4594775
138755920	138755942	3	+	27760321	MV411	viability	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	1.2690361817780103	[108,82]	[246,7]	8	hSpCas9	negative selection	4594776
138707158	138707180	3	-	27760321	HL60	viability	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	0.7723800950083033	[150,158]	[231,201]	8	hSpCas9	negative selection	4678235
138712277	138712299	3	+	27760321	HL60	viability	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	-0.38524353882422924	[239,188]	[175,87]	-4	hSpCas9	negative selection	4678236
138714660	138714682	3	+	27760321	HL60	viability	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	0.5339524676886064	[178,187]	[273,158]	6	hSpCas9	negative selection	4678237
138737761	138737783	3	+	27760321	HL60	viability	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	-0.5165666609402217	[29,18]	[22,3]	-5	hSpCas9	negative selection	4678238
138755920	138755942	3	+	27760321	HL60	viability	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	-0.20146686630137411	[108,82]	[39,96]	-2	hSpCas9	negative selection	4678239
138707158	138707180	3	-	27760321	HT1080	viability	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	-1.2958368529931974	[158,123]	[0,46]	-5	hSpCas9	negative selection	4761698
138712277	138712299	3	+	27760321	HT1080	viability	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	0.11210588667307675	[188,147]	[94,47]	0	hSpCas9	negative selection	4761699
138714660	138714682	3	+	27760321	HT1080	viability	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	-1.1371473761790682	[187,146]	[26,33]	-4	hSpCas9	negative selection	4761700
138737761	138737783	3	+	27760321	HT1080	viability	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	-2.7606711187674797	[18,14]	[0,0]	-7	hSpCas9	negative selection	4761701
138755920	138755942	3	+	27760321	HT1080	viability	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	1.0547993312281279	[82,64]	[34,89]	6	hSpCas9	negative selection	4761702
138707158	138707180	3	-	27760321	HT29	viability after 7 days	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	-0.3285313066942943	[158,123]	[197,67,174]	-5	hSpCas9	negative selection	4845161
138712277	138712299	3	+	27760321	HT29	viability after 7 days	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	-0.5697093633076862	[188,147]	[106,108,213]	-7	hSpCas9	negative selection	4845162
138714660	138714682	3	+	27760321	HT29	viability after 7 days	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	-1.2113510445910987	[187,146]	[96,105,76]	-9	hSpCas9	negative selection	4845163
138737761	138737783	3	+	27760321	HT29	viability after 7 days	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	-0.586425699669566	[18,14]	[15,16,10]	-7	hSpCas9	negative selection	4845164
138755920	138755942	3	+	27760321	HT29	viability after 7 days	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	0.38463560471682445	[82,64]	[221,56,107]	6	hSpCas9	negative selection	4845165
138707158	138707180	3	-	27760321	HT29	viability after 25 days	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	-0.7361086570661692	[158,123]	[75,53,169]	-6	hSpCas9	negative selection	4928624
138712277	138712299	3	+	27760321	HT29	viability after 25 days	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	-0.11374889839200253	[188,147]	[65,182,304]	-1	hSpCas9	negative selection	4928625
138714660	138714682	3	+	27760321	HT29	viability after 25 days	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	-0.7830785689234065	[187,146]	[72,168,91]	-6	hSpCas9	negative selection	4928626
138737761	138737783	3	+	27760321	HT29	viability after 25 days	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	-0.6252357515522613	[18,14]	[2,8,27]	-5	hSpCas9	negative selection	4928627
138755920	138755942	3	+	27760321	HT29	viability after 25 days	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	0.09168940269644432	[82,64]	[76,78,117]	0	hSpCas9	negative selection	4928628
138707158	138707180	3	-	27760321	HT29	viability after 22 days	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	0.09803265810134554	[158,123]	[157,158,208]	1	hSpCas9	negative selection	5012087
138712277	138712299	3	+	27760321	HT29	viability after 22 days	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	-0.7902086157713291	[188,147]	[79,132,125]	-6	hSpCas9	negative selection	5012088
138714660	138714682	3	+	27760321	HT29	viability after 22 days	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	-0.9730501804403324	[187,146]	[131,70,91]	-6	hSpCas9	negative selection	5012089
138737761	138737783	3	+	27760321	HT29	viability after 22 days	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	-1.6147778631443508	[18,14]	[14,0,2]	-7	hSpCas9	negative selection	5012090
138755920	138755942	3	+	27760321	HT29	viability after 22 days	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	-0.19617106725159728	[82,64]	[16,93,114]	-2	hSpCas9	negative selection	5012091
138707158	138707180	3	-	27760321	HT29	viability after 19 days	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	0.37286757668200865	[158,123]	[204,185,235]	3	hSpCas9	negative selection	5095550
138712277	138712299	3	+	27760321	HT29	viability after 19 days	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	-1.2923147200240015	[188,147]	[74,117,43]	-7	hSpCas9	negative selection	5095551
138714660	138714682	3	+	27760321	HT29	viability after 19 days	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	-1.5675157930414192	[187,146]	[92,96,8]	-7	hSpCas9	negative selection	5095552
138737761	138737783	3	+	27760321	HT29	viability after 19 days	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	-0.5257718575492571	[18,14]	[41,0,0]	-4	hSpCas9	negative selection	5095553
138755920	138755942	3	+	27760321	HT29	viability after 19 days	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	0.2956714514136649	[82,64]	[84,102,120]	3	hSpCas9	negative selection	5095554
138707158	138707180	3	-	27760321	HT29	viability after 16 days	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	-1.5781289443216844	[158,123]	[83,51,25]	-8	hSpCas9	negative selection	5179013
138712277	138712299	3	+	27760321	HT29	viability after 16 days	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	0.011008106350986147	[188,147]	[182,201,183]	0	hSpCas9	negative selection	5179014
138714660	138714682	3	+	27760321	HT29	viability after 16 days	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	-0.8447543527122912	[187,146]	[121,131,59]	-6	hSpCas9	negative selection	5179015
138737761	138737783	3	+	27760321	HT29	viability after 16 days	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	-2.0889945797492313	[18,14]	[0,7,3]	-8	hSpCas9	negative selection	5179016
138755920	138755942	3	+	27760321	HT29	viability after 16 days	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	0.3959498857759465	[82,64]	[40,125,152]	4	hSpCas9	negative selection	5179017
138707158	138707180	3	-	27760321	HT29	viability after 13 days	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	0.017601858463720976	[158,123]	[152,153,189]	0	hSpCas9	negative selection	5262476
138712277	138712299	3	+	27760321	HT29	viability after 13 days	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	0.5577727163886663	[188,147]	[369,338,161]	7	hSpCas9	negative selection	5262477
138714660	138714682	3	+	27760321	HT29	viability after 13 days	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	-1.5358207967474924	[187,146]	[64,101,35]	-8	hSpCas9	negative selection	5262478
138737761	138737783	3	+	27760321	HT29	viability after 13 days	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	-2.3868993776353884	[18,14]	[0,0,8]	-9	hSpCas9	negative selection	5262479
138755920	138755942	3	+	27760321	HT29	viability after 13 days	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	0.14292481992318207	[82,64]	[23,155,103]	1	hSpCas9	negative selection	5262480
138707158	138707180	3	-	27760321	HT29	viability after 10 days	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	-0.6076452997817441	[158,123]	[153,82,109]	-6	hSpCas9	negative selection	5345939
138712277	138712299	3	+	27760321	HT29	viability after 10 days	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	-0.6544873627723362	[188,147]	[46,211,143]	-6	hSpCas9	negative selection	5345940
138714660	138714682	3	+	27760321	HT29	viability after 10 days	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	-1.073503834830581	[187,146]	[93,58,142]	-8	hSpCas9	negative selection	5345941
138737761	138737783	3	+	27760321	HT29	viability after 10 days	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	-4.40866621723361	[18,14]	[0,0,0]	-9	hSpCas9	negative selection	5345942
138755920	138755942	3	+	27760321	HT29	viability after 10 days	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	0.17010377626100937	[82,64]	[44,91,172]	2	hSpCas9	negative selection	5345943
138707158	138707180	3	-	27760321	MOLM13	viability	TATTACCCTCCCTTCGATAAGG	PIK3CB	ENSG00000051382	-0.47203443282882174	[150,158]	[37,84]	-3	hSpCas9	negative selection	5429402
138712277	138712299	3	+	27760321	MOLM13	viability	TCGTATTTACCCACGCTACAGG	PIK3CB	ENSG00000051382	1.3031279962403897	[239,188]	[367,235]	8	hSpCas9	negative selection	5429403
138714660	138714682	3	+	27760321	MOLM13	viability	GCTTACGATGGTTTTACACAGG	PIK3CB	ENSG00000051382	-1.2594452479882596	[178,187]	[63,25]	-6	hSpCas9	negative selection	5429404
138737761	138737783	3	+	27760321	MOLM13	viability	TTGCAACACATAATCATAGGGG	PIK3CB	ENSG00000051382	-0.2734337393193842	[29,18]	[0,19]	-2	hSpCas9	negative selection	5429405
138755920	138755942	3	+	27760321	MOLM13	viability	GGAGTCAATATCCATAAGGAGG	PIK3CB	ENSG00000051382	1.0879005154633337	[108,82]	[16,196]	7	hSpCas9	negative selection	5429406
138834439	138834462	3	-	27661255	K562	viability	GGCGCCCCCCGGCCCCTGGGCGG	PIK3CB	ENSG00000051382	-0.11739447323404995	[1452,1276]	[1169,868]	-4	dCas9-KRAB	negative selection	5501918
138834512	138834535	3	-	27661255	K562	viability	GAGGATAACCGCCTACCGGCCGG	PIK3CB	ENSG00000051382	-0.1183896046837522	[698,728]	[578,478]	-4	dCas9-KRAB	negative selection	5501919
138834875	138834898	3	-	27661255	K562	viability	GCGTGCTCTGTCGGCCTGTGCGG	PIK3CB	ENSG00000051382	0.3215744317614817	[82,123]	[114,91]	9	dCas9-KRAB	negative selection	5501920
138834906	138834929	3	-	27661255	K562	viability	GCACACGGGCGCGGGTTCGGCGG	PIK3CB	ENSG00000051382	0.04950210811218407	[767,752]	[744,529]	1	dCas9-KRAB	negative selection	5501921
138759196	138759219	3	+	27260156	BXPC3	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.49052032103889864	[134]	[175,151,233,240]	9	hSpCas9	negative selection	5562745
138759280	138759303	3	+	27260156	BXPC3	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.24799145133076927	[843]	[597,712,696,1008]	-5	hSpCas9	negative selection	5562746
138755795	138755818	3	-	27260156	BXPC3	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.2478337868191708	[670]	[542,480,618,747]	-5	hSpCas9	negative selection	5562747
138755810	138755833	3	+	27260156	BXPC3	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.3202907215717077	[175]	[115,148,166,161]	-6	hSpCas9	negative selection	5626997
138737753	138737776	3	-	27260156	BXPC3	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.01662217255737808	[559]	[390,561,580,829]	0	hSpCas9	negative selection	5626998
138737702	138737725	3	+	27260156	BXPC3	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.49841676066444046	[691]	[464,437,443,733]	-8	hSpCas9	negative selection	5626999
138759196	138759219	3	+	27260156	A673	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.2167538296611291	[134]	[245,158,148,207]	5	hSpCas9	negative selection	5683996
138759280	138759303	3	+	27260156	A673	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.07536426516876427	[843]	[1019,865,892,1082]	-2	hSpCas9	negative selection	5683997
138755795	138755818	3	-	27260156	A673	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.03014369927285765	[670]	[879,730,806,745]	0	hSpCas9	negative selection	5683998
138755810	138755833	3	+	27260156	A673	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.2630495314693919	[175]	[302,215,256,243]	6	hSpCas9	negative selection	5748248
138737753	138737776	3	-	27260156	A673	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	0.07686163233852966	[559]	[678,641,653,867]	1	hSpCas9	negative selection	5748249
138737702	138737725	3	+	27260156	A673	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.38664598613587714	[691]	[733,580,618,618]	-7	hSpCas9	negative selection	5748250
138759196	138759219	3	+	27260156	A375	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.24359880684679402	[134]	[117,317,207,126]	3	hSpCas9	negative selection	5805247
138759280	138759303	3	+	27260156	A375	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.20921373574020985	[843]	[820,1047,911,674]	-3	hSpCas9	negative selection	5805248
138755795	138755818	3	-	27260156	A375	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.09252430289043984	[670]	[624,1061,809,511]	-1	hSpCas9	negative selection	5805249
138755810	138755833	3	+	27260156	A375	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.5544872476680334	[175]	[90,107,145,201]	-6	hSpCas9	negative selection	5869499
138737753	138737776	3	-	27260156	A375	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.12980914281952158	[559]	[510,764,745,411]	-2	hSpCas9	negative selection	5869500
138737702	138737725	3	+	27260156	A375	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.7059548896671817	[691]	[337,476,579,571]	-7	hSpCas9	negative selection	5869501
138759196	138759219	3	+	27260156	COLO741	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.02079962636740107	[134]	[242,150,138]	0	hSpCas9	negative selection	5926498
138759280	138759303	3	+	27260156	COLO741	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.048951839047126744	[843]	[1109,1217,1022]	1	hSpCas9	negative selection	5926499
138755795	138755818	3	-	27260156	COLO741	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.07869962078599091	[670]	[1009,739,967]	1	hSpCas9	negative selection	5926500
138755810	138755833	3	+	27260156	COLO741	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.1722610866300225	[175]	[163,310,125]	-4	hSpCas9	negative selection	5990750
138737753	138737776	3	-	27260156	COLO741	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.421712672832401	[559]	[691,494,434]	-7	hSpCas9	negative selection	5990751
138737702	138737725	3	+	27260156	COLO741	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.49073785755168653	[691]	[643,662,583]	-8	hSpCas9	negative selection	5990752
138759196	138759219	3	+	27260156	CAL120	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	-0.2533772003332577	[134]	[139,107,173]	-4	hSpCas9	negative selection	6047749
138759280	138759303	3	+	27260156	CAL120	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.16117310108294414	[843]	[1559,760,595]	-2	hSpCas9	negative selection	6047750
138755795	138755818	3	-	27260156	CAL120	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.28958309316795416	[670]	[613,589,831]	-4	hSpCas9	negative selection	6047751
138755810	138755833	3	+	27260156	CAL120	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.3094271668148971	[175]	[500,263,86]	4	hSpCas9	negative selection	6112001
138737753	138737776	3	-	27260156	CAL120	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.3935483246838513	[559]	[433,571,569]	-5	hSpCas9	negative selection	6112002
138737702	138737725	3	+	27260156	CAL120	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.593615609211255	[691]	[607,520,587]	-7	hSpCas9	negative selection	6112003
138759196	138759219	3	+	27260156	CADOES1	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.5719057963409917	[134]	[176,147,170,252]	8	hSpCas9	negative selection	6169000
138759280	138759303	3	+	27260156	CADOES1	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.2932209770518157	[843]	[558,506,785,712]	-5	hSpCas9	negative selection	6169001
138755795	138755818	3	-	27260156	CADOES1	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.0886420846571696	[670]	[748,642,705,551]	1	hSpCas9	negative selection	6169002
138755810	138755833	3	+	27260156	CADOES1	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.005069072135111874	[175]	[111,214,154,170]	0	hSpCas9	negative selection	6233252
138737753	138737776	3	-	27260156	CADOES1	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.08977053736882037	[559]	[518,407,499,531]	-1	hSpCas9	negative selection	6233253
138737702	138737725	3	+	27260156	CADOES1	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.3659594791791157	[691]	[468,411,501,618]	-6	hSpCas9	negative selection	6233254
138759196	138759219	3	+	27260156	EWS502	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.4376510805572442	[134]	[187,171,187,229]	7	hSpCas9	negative selection	6290251
138759280	138759303	3	+	27260156	EWS502	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.21930232343071232	[843]	[590,857,818,822]	-4	hSpCas9	negative selection	6290252
138755795	138755818	3	-	27260156	EWS502	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.16467118172565065	[670]	[699,762,786,957]	3	hSpCas9	negative selection	6290253
138755810	138755833	3	+	27260156	EWS502	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.21664790520619004	[175]	[128,163,81,276]	-4	hSpCas9	negative selection	6354503
138737753	138737776	3	-	27260156	EWS502	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.08017679790220164	[559]	[516,583,421,733]	-1	hSpCas9	negative selection	6354504
138737702	138737725	3	+	27260156	EWS502	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.38354997450544526	[691]	[471,719,425,634]	-6	hSpCas9	negative selection	6354505
138759196	138759219	3	+	27260156	EW8	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.005282630579934944	[134]	[80,179,110,63]	0	hSpCas9	negative selection	6411502
138759280	138759303	3	+	27260156	EW8	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.1453121214428411	[843]	[761,602,498,643]	-3	hSpCas9	negative selection	6411503
138755795	138755818	3	-	27260156	EW8	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.1478062743976697	[670]	[648,567,354,430]	-3	hSpCas9	negative selection	6411504
138755810	138755833	3	+	27260156	EW8	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.1062083221144694	[175]	[148,250,122,95]	2	hSpCas9	negative selection	6475754
138737753	138737776	3	-	27260156	EW8	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	0.07702318935958252	[559]	[455,473,459,523]	1	hSpCas9	negative selection	6475755
138737702	138737725	3	+	27260156	EW8	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.29848068407462663	[691]	[543,314,440,533]	-5	hSpCas9	negative selection	6475756
138759196	138759219	3	+	27260156	CORL105	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.5128800003755201	[134]	[142,213,256,289]	8	hSpCas9	negative selection	6532753
138759280	138759303	3	+	27260156	CORL105	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.09013421342490435	[843]	[1079,894,1003,751]	-2	hSpCas9	negative selection	6532754
138755795	138755818	3	-	27260156	CORL105	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.07330434896616567	[670]	[876,700,1035,728]	1	hSpCas9	negative selection	6532755
138755810	138755833	3	+	27260156	CORL105	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.168075138669735	[175]	[313,166,255,196]	3	hSpCas9	negative selection	6597005
138737753	138737776	3	-	27260156	CORL105	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.17093856975159644	[559]	[582,610,452,660]	-3	hSpCas9	negative selection	6597006
138737702	138737725	3	+	27260156	CORL105	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.44844706638833676	[691]	[681,511,673,523]	-7	hSpCas9	negative selection	6597007
138759196	138759219	3	+	27260156	HS294T	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.9464379233596707	[134]	[106,60,62,185]	9	hSpCas9	negative selection	6654004
138759280	138759303	3	+	27260156	HS294T	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.033791788596858496	[843]	[347,341,266,384]	0	hSpCas9	negative selection	6654005
138755795	138755818	3	-	27260156	HS294T	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.16344177722515663	[670]	[403,235,181,337]	2	hSpCas9	negative selection	6654006
138755810	138755833	3	+	27260156	HS294T	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.3589082183558523	[175]	[44,38,67,62]	-5	hSpCas9	negative selection	6718256
138737753	138737776	3	-	27260156	HS294T	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.1772267222817226	[559]	[228,227,158,134]	-2	hSpCas9	negative selection	6718257
138737702	138737725	3	+	27260156	HS294T	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.6995052964134632	[691]	[114,170,182,199]	-7	hSpCas9	negative selection	6718258
138759196	138759219	3	+	27260156	HCC44	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.6821433184166796	[134]	[186,134,246,413]	9	hSpCas9	negative selection	6775255
138759280	138759303	3	+	27260156	HCC44	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.08363292294312907	[843]	[1159,728,1197,1035]	1	hSpCas9	negative selection	6775256
138755795	138755818	3	-	27260156	HCC44	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.13496631773123074	[670]	[792,455,830,743]	-2	hSpCas9	negative selection	6775257
138755810	138755833	3	+	27260156	HCC44	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.15066204263353167	[175]	[231,199,302,166]	2	hSpCas9	negative selection	6839507
138737753	138737776	3	-	27260156	HCC44	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.17205149085879734	[559]	[515,490,917,391]	-3	hSpCas9	negative selection	6839508
138737702	138737725	3	+	27260156	HCC44	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.23412286658130177	[691]	[801,798,666,390]	-4	hSpCas9	negative selection	6839509
138759196	138759219	3	+	27260156	G402	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	-0.682719858850868	[134]	[153,119,51,92]	-7	hSpCas9	negative selection	6896506
138759280	138759303	3	+	27260156	G402	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.37526286089891664	[843]	[1220,770,676,574]	-5	hSpCas9	negative selection	6896507
138755795	138755818	3	-	27260156	G402	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.0746217747639547	[670]	[826,1174,538,914]	0	hSpCas9	negative selection	6896508
138755810	138755833	3	+	27260156	G402	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.07021562429327877	[175]	[155,62,395,187]	-1	hSpCas9	negative selection	6960758
138737753	138737776	3	-	27260156	G402	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	0.24999750610863558	[559]	[700,889,1157,501]	3	hSpCas9	negative selection	6960759
138737702	138737725	3	+	27260156	G402	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.6691065752913841	[691]	[560,664,394,513]	-7	hSpCas9	negative selection	6960760
138759196	138759219	3	+	27260156	L33	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.43932280154790004	[134]	[200,67,119,173]	8	hSpCas9	negative selection	7017757
138759280	138759303	3	+	27260156	L33	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.29385113835950016	[843]	[1118,462,540,1025]	6	hSpCas9	negative selection	7017758
138755795	138755818	3	-	27260156	L33	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.08942214588037328	[670]	[724,232,379,621]	-2	hSpCas9	negative selection	7017759
138755810	138755833	3	+	27260156	L33	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.07056485004219115	[175]	[220,98,87,135]	1	hSpCas9	negative selection	7082009
138737753	138737776	3	-	27260156	L33	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.05725933697375296	[559]	[440,212,373,598]	-1	hSpCas9	negative selection	7082010
138737702	138737725	3	+	27260156	L33	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.21700253413618875	[691]	[658,189,423,582]	-5	hSpCas9	negative selection	7082011
138759196	138759219	3	+	27260156	K562	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.9373866112057601	[134]	[424,174,176,160]	9	hSpCas9	negative selection	7139008
138759280	138759303	3	+	27260156	K562	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.016098405131908855	[843]	[659,784,988,603]	0	hSpCas9	negative selection	7139009
138755795	138755818	3	-	27260156	K562	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.0338724592491676	[670]	[1034,484,606,365]	0	hSpCas9	negative selection	7139010
138755810	138755833	3	+	27260156	K562	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.47133301720763887	[175]	[212,454,148,76]	6	hSpCas9	negative selection	7203260
138737753	138737776	3	-	27260156	K562	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	0.13787672823845948	[559]	[649,502,594,453]	1	hSpCas9	negative selection	7203261
138737702	138737725	3	+	27260156	K562	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.7041634796483477	[691]	[447,357,403,308]	-7	hSpCas9	negative selection	7203262
138759196	138759219	3	+	27260156	HT29	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.12453272182429598	[134]	[197,172,162,180]	2	hSpCas9	negative selection	7260259
138759280	138759303	3	+	27260156	HT29	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.19590789714675727	[843]	[891,805,989,881]	-4	hSpCas9	negative selection	7260260
138755795	138755818	3	-	27260156	HT29	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.19702034960599457	[670]	[1076,976,930,781]	4	hSpCas9	negative selection	7260261
138755810	138755833	3	+	27260156	HT29	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.06440047167863372	[175]	[337,108,219,224]	1	hSpCas9	negative selection	7324511
138737753	138737776	3	-	27260156	HT29	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	0.28742884818066516	[559]	[879,872,833,747]	5	hSpCas9	negative selection	7324512
138737702	138737725	3	+	27260156	HT29	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.49232448922423544	[691]	[776,601,552,483]	-7	hSpCas9	negative selection	7324513
138759196	138759219	3	+	27260156	MHHES1	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.5351334647506887	[134]	[221,111,240,276]	8	hSpCas9	negative selection	7381510
138759280	138759303	3	+	27260156	MHHES1	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.11345013137606264	[843]	[1234,1100,715,1059]	2	hSpCas9	negative selection	7381511
138755795	138755818	3	-	27260156	MHHES1	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.09058668027196726	[670]	[1084,823,722,641]	1	hSpCas9	negative selection	7381512
138755810	138755833	3	+	27260156	MHHES1	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.34829469239490174	[175]	[225,230,276,261]	6	hSpCas9	negative selection	7445762
138737753	138737776	3	-	27260156	MHHES1	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	0.17801717103240716	[559]	[706,759,978,457]	3	hSpCas9	negative selection	7445763
138737702	138737725	3	+	27260156	MHHES1	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.09858391788062704	[691]	[1165,825,728,330]	-2	hSpCas9	negative selection	7445764
138759196	138759219	3	+	27260156	MEWO	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.43590333188081143	[134]	[157,177,173]	8	hSpCas9	negative selection	7502761
138759280	138759303	3	+	27260156	MEWO	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.14542028709755617	[843]	[880,697,594]	-3	hSpCas9	negative selection	7502762
138755795	138755818	3	-	27260156	MEWO	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.4465289114804712	[670]	[476,466,440]	-7	hSpCas9	negative selection	7502763
138755810	138755833	3	+	27260156	MEWO	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.1614344099077003	[175]	[133,164,139]	-4	hSpCas9	negative selection	7567013
138737753	138737776	3	-	27260156	MEWO	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.5537553489750235	[559]	[434,313,336]	-8	hSpCas9	negative selection	7567014
138737702	138737725	3	+	27260156	MEWO	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.9088259546589956	[691]	[346,305,381]	-9	hSpCas9	negative selection	7567015
138759196	138759219	3	+	27260156	LNCAPCLONEFGC	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.2480518804927907	[134]	[111,132,176,164]	4	hSpCas9	negative selection	7624012
138759280	138759303	3	+	27260156	LNCAPCLONEFGC	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.2819523939368893	[843]	[577,822,574,518]	-4	hSpCas9	negative selection	7624013
138755795	138755818	3	-	27260156	LNCAPCLONEFGC	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.13218282530984848	[670]	[456,541,656,579]	-2	hSpCas9	negative selection	7624014
138755810	138755833	3	+	27260156	LNCAPCLONEFGC	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.2569979633058057	[175]	[105,176,77,161]	-4	hSpCas9	negative selection	7688264
138737753	138737776	3	-	27260156	LNCAPCLONEFGC	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.518920301795138	[559]	[289,269,517,368]	-7	hSpCas9	negative selection	7688265
138737702	138737725	3	+	27260156	LNCAPCLONEFGC	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.9595853029408353	[691]	[236,272,429,369]	-8	hSpCas9	negative selection	7688266
138759196	138759219	3	+	27260156	PANC0327	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.5036306024897172	[134]	[109,115,164,290]	7	hSpCas9	negative selection	7745263
138759280	138759303	3	+	27260156	PANC0327	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.049445251004960444	[843]	[737,594,976,605]	0	hSpCas9	negative selection	7745264
138755795	138755818	3	-	27260156	PANC0327	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.2202134400359832	[670]	[632,397,442,596]	-3	hSpCas9	negative selection	7745265
138755810	138755833	3	+	27260156	PANC0327	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.11034887846755392	[175]	[155,190,117,205]	1	hSpCas9	negative selection	7809515
138737753	138737776	3	-	27260156	PANC0327	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.04283173990120115	[559]	[484,505,623,313]	0	hSpCas9	negative selection	7809516
138737702	138737725	3	+	27260156	PANC0327	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.17811593367861062	[691]	[580,624,659,299]	-3	hSpCas9	negative selection	7809517
138759196	138759219	3	+	27260156	NCIH2009	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.20609154542532937	[134]	[345,203,127]	3	hSpCas9	negative selection	7866514
138759280	138759303	3	+	27260156	NCIH2009	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.1648642140040819	[843]	[1384,1050,1544]	2	hSpCas9	negative selection	7866515
138755795	138755818	3	-	27260156	NCIH2009	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.1166364128400954	[670]	[1273,670,731]	-2	hSpCas9	negative selection	7866516
138755810	138755833	3	+	27260156	NCIH2009	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.12531271938437838	[175]	[158,214,288]	-2	hSpCas9	negative selection	7930766
138737753	138737776	3	-	27260156	NCIH2009	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.4568051557918127	[559]	[872,464,432]	-5	hSpCas9	negative selection	7930767
138737702	138737725	3	+	27260156	NCIH2009	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.39150048096911183	[691]	[977,655,624]	-5	hSpCas9	negative selection	7930768
138759196	138759219	3	+	27260156	NCIH1373	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.3270981777845494	[134]	[217,310,85,34]	3	hSpCas9	negative selection	7987765
138759280	138759303	3	+	27260156	NCIH1373	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.2928045856409972	[843]	[1007,688,582,225]	-3	hSpCas9	negative selection	7987766
138755795	138755818	3	-	27260156	NCIH1373	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.1973754508550909	[670]	[640,678,619,177]	-2	hSpCas9	negative selection	7987767
138755810	138755833	3	+	27260156	NCIH1373	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.8038692834060521	[175]	[139,60,127,34]	-7	hSpCas9	negative selection	8052017
138737753	138737776	3	-	27260156	NCIH1373	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.5927524965254585	[559]	[319,293,462,155]	-5	hSpCas9	negative selection	8052018
138737702	138737725	3	+	27260156	NCIH1373	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.715951878154923	[691]	[466,396,394,169]	-6	hSpCas9	negative selection	8052019
138759196	138759219	3	+	27260156	PATU8902	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.1135312992595372	[134]	[157,83,106,526]	1	hSpCas9	negative selection	8109016
138759280	138759303	3	+	27260156	PATU8902	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.22159239719978263	[843]	[1197,1117,1187,2103]	2	hSpCas9	negative selection	8109017
138755795	138755818	3	-	27260156	PATU8902	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.3221628213946194	[670]	[1363,1129,822,1469]	3	hSpCas9	negative selection	8109018
138755810	138755833	3	+	27260156	PATU8902	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.019571143119610168	[175]	[407,295,71,229]	0	hSpCas9	negative selection	8173268
138737753	138737776	3	-	27260156	PATU8902	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.05344251923037052	[559]	[825,421,722,1072]	0	hSpCas9	negative selection	8173269
138737702	138737725	3	+	27260156	PATU8902	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.08574641659013538	[691]	[657,779,856,1405]	-1	hSpCas9	negative selection	8173270
138759196	138759219	3	+	27260156	PANC1	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.1707320258436893	[134]	[234,190,46,66]	2	hSpCas9	negative selection	8230267
138759280	138759303	3	+	27260156	PANC1	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.1922955945812449	[843]	[447,1088,668,449]	-3	hSpCas9	negative selection	8230268
138755795	138755818	3	-	27260156	PANC1	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.12810424850744395	[670]	[535,398,455,659]	-2	hSpCas9	negative selection	8230269
138755810	138755833	3	+	27260156	PANC1	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.2566953733691777	[175]	[101,137,199,75]	-4	hSpCas9	negative selection	8294519
138737753	138737776	3	-	27260156	PANC1	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.14922588268592413	[559]	[474,631,398,285]	-2	hSpCas9	negative selection	8294520
138737702	138737725	3	+	27260156	PANC1	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.9215678356772037	[691]	[269,457,344,222]	-8	hSpCas9	negative selection	8294521
138759196	138759219	3	+	27260156	PANC0813	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.6948668338458079	[134]	[201,234,333,250]	9	hSpCas9	negative selection	8351518
138759280	138759303	3	+	27260156	PANC0813	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.12308364668775729	[843]	[1358,1045,1118,832]	2	hSpCas9	negative selection	8351519
138755795	138755818	3	-	27260156	PANC0813	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.0753653072873055	[670]	[767,758,653,807]	-1	hSpCas9	negative selection	8351520
138755810	138755833	3	+	27260156	PANC0813	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.07855706963657605	[175]	[267,220,148,237]	1	hSpCas9	negative selection	8415770
138737753	138737776	3	-	27260156	PANC0813	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.4080253286412804	[559]	[719,362,446,473]	-6	hSpCas9	negative selection	8415771
138737702	138737725	3	+	27260156	PANC0813	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.3949930677215593	[691]	[601,636,713,522]	-6	hSpCas9	negative selection	8415772
138759196	138759219	3	+	27260156	RDES	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.8040054608115618	[134]	[277,290,239,258]	9	hSpCas9	negative selection	8472769
138759280	138759303	3	+	27260156	RDES	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.09212859565683607	[843]	[649,932,1074,1037]	-1	hSpCas9	negative selection	8472770
138755795	138755818	3	-	27260156	RDES	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.0026968321706548615	[670]	[658,710,912,829]	0	hSpCas9	negative selection	8472771
138755810	138755833	3	+	27260156	RDES	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.07593537430656094	[175]	[179,123,223,253]	-1	hSpCas9	negative selection	8537021
138737753	138737776	3	-	27260156	RDES	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.052685354426346254	[559]	[517,569,701,719]	-1	hSpCas9	negative selection	8537022
138737702	138737725	3	+	27260156	RDES	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.5983369446961757	[691]	[411,564,565,572]	-8	hSpCas9	negative selection	8537023
138759196	138759219	3	+	27260156	PC3	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.3532453509387705	[134]	[80,242,200,196]	7	hSpCas9	negative selection	8594020
138759280	138759303	3	+	27260156	PC3	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.2194141196770244	[843]	[367,775,1124,877]	-5	hSpCas9	negative selection	8594021
138755795	138755818	3	-	27260156	PC3	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.19034838829692524	[670]	[332,619,968,629]	-4	hSpCas9	negative selection	8594022
138755810	138755833	3	+	27260156	PC3	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.1532799503659812	[175]	[121,203,121,162]	-3	hSpCas9	negative selection	8658272
138737753	138737776	3	-	27260156	PC3	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.4898360092171494	[559]	[214,384,855,357]	-8	hSpCas9	negative selection	8658273
138737702	138737725	3	+	27260156	PC3	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.8804874156168043	[691]	[139,372,568,580]	-9	hSpCas9	negative selection	8658274
138759196	138759219	3	+	27260156	PATU8988T	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	-0.8210994319970368	[134]	[122,98,28,44]	-8	hSpCas9	negative selection	8715271
138759280	138759303	3	+	27260156	PATU8988T	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.2496118768880239	[843]	[529,775,858,575]	-4	hSpCas9	negative selection	8715272
138755795	138755818	3	-	27260156	PATU8988T	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.4828415695841458	[670]	[354,557,303,665]	-7	hSpCas9	negative selection	8715273
138755810	138755833	3	+	27260156	PATU8988T	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.218026339852041	[175]	[178,118,102,184]	-4	hSpCas9	negative selection	8779523
138737753	138737776	3	-	27260156	PATU8988T	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.13112010064518048	[559]	[488,471,322,709]	-2	hSpCas9	negative selection	8779524
138737702	138737725	3	+	27260156	PATU8988T	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.7519483559935187	[691]	[444,218,400,515]	-8	hSpCas9	negative selection	8779525
138759196	138759219	3	+	27260156	T47D	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.26981891918970513	[134]	[222,180,138,217]	6	hSpCas9	negative selection	8836522
138759280	138759303	3	+	27260156	T47D	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.12340654388822081	[843]	[1047,820,904,841]	-3	hSpCas9	negative selection	8836523
138755795	138755818	3	-	27260156	T47D	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.042931004801197825	[670]	[857,599,810,779]	-1	hSpCas9	negative selection	8836524
138755810	138755833	3	+	27260156	T47D	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.03736826734665777	[175]	[168,247,172,249]	0	hSpCas9	negative selection	8900774
138737753	138737776	3	-	27260156	T47D	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	0.1439073139394595	[559]	[697,730,749,701]	3	hSpCas9	negative selection	8900775
138737702	138737725	3	+	27260156	T47D	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.44848377633887215	[691]	[587,465,596,726]	-7	hSpCas9	negative selection	8900776
138759196	138759219	3	+	27260156	SU8686	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.6444294318351935	[134]	[270,157,211,190]	9	hSpCas9	negative selection	8957773
138759280	138759303	3	+	27260156	SU8686	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.13208681564866875	[843]	[936,846,870,1029]	2	hSpCas9	negative selection	8957774
138755795	138755818	3	-	27260156	SU8686	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.0025512018174774775	[670]	[629,533,660,893]	0	hSpCas9	negative selection	8957775
138755810	138755833	3	+	27260156	SU8686	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.2428925934542201	[175]	[216,169,183,265]	4	hSpCas9	negative selection	9022025
138737753	138737776	3	-	27260156	SU8686	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.15343233700094755	[559]	[498,440,633,416]	-3	hSpCas9	negative selection	9022026
138737702	138737725	3	+	27260156	SU8686	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.27310647335910054	[691]	[575,406,644,678]	-4	hSpCas9	negative selection	9022027
138759196	138759219	3	+	27260156	SKES1	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.4689046640716972	[134]	[190,289,142,138]	8	hSpCas9	negative selection	9079024
138759280	138759303	3	+	27260156	SKES1	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.060947900970080626	[843]	[826,909,770,735]	-1	hSpCas9	negative selection	9079025
138755795	138755818	3	-	27260156	SKES1	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.02637812634043274	[670]	[725,701,654,564]	0	hSpCas9	negative selection	9079026
138755810	138755833	3	+	27260156	SKES1	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.2762426273402181	[175]	[294,315,151,120]	6	hSpCas9	negative selection	9143276
138737753	138737776	3	-	27260156	SKES1	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.013755037602107861	[559]	[832,553,469,407]	0	hSpCas9	negative selection	9143277
138737702	138737725	3	+	27260156	SKES1	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.34979343279511255	[691]	[609,621,492,464]	-6	hSpCas9	negative selection	9143278
138759196	138759219	3	+	27260156	TOV112D	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	-0.41662975759655585	[134]	[114,148,55,97]	-7	hSpCas9	negative selection	9200275
138759280	138759303	3	+	27260156	TOV112D	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	0.0988770725265391	[843]	[1053,768,667,1101]	2	hSpCas9	negative selection	9200276
138755795	138755818	3	-	27260156	TOV112D	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	0.168229553283203	[670]	[579,1272,883,404]	3	hSpCas9	negative selection	9200277
138755810	138755833	3	+	27260156	TOV112D	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	-0.3699640106263973	[175]	[130,163,166,90]	-6	hSpCas9	negative selection	9264527
138737753	138737776	3	-	27260156	TOV112D	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	0.04680810439144656	[559]	[669,580,619,456]	0	hSpCas9	negative selection	9264528
138737702	138737725	3	+	27260156	TOV112D	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.8361220027917752	[691]	[330,492,316,430]	-9	hSpCas9	negative selection	9264529
138759196	138759219	3	+	27260156	TC71	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	0.27675874435899894	[134]	[189,203,135,171]	6	hSpCas9	negative selection	9321526
138759280	138759303	3	+	27260156	TC71	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.097738774409868	[843]	[829,778,889,883]	-3	hSpCas9	negative selection	9321527
138755795	138755818	3	-	27260156	TC71	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.044679444261649326	[670]	[627,687,747,726]	-1	hSpCas9	negative selection	9321528
138755810	138755833	3	+	27260156	TC71	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.05956577201756552	[175]	[150,235,185,215]	1	hSpCas9	negative selection	9385778
138737753	138737776	3	-	27260156	TC71	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	0.07384447345178285	[559]	[522,687,653,665]	2	hSpCas9	negative selection	9385779
138737702	138737725	3	+	27260156	TC71	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.47150880142913515	[691]	[568,461,560,546]	-8	hSpCas9	negative selection	9385780
138759196	138759219	3	+	27260156	TC32	viability	CTTCCCGAGGTACCTCCAACTGG	PIK3CB	ENSG00000051382	-0.028950181861561397	[134]	[150,34,95,240]	0	hSpCas9	negative selection	9442777
138759280	138759303	3	+	27260156	TC32	viability	AATCCACCGCCCAGATGTCAAGG	PIK3CB	ENSG00000051382	-0.30552877828207525	[843]	[643,304,911,857]	-5	hSpCas9	negative selection	9442778
138755795	138755818	3	-	27260156	TC32	viability	GTGACAAGAAGTTGTGACCCAGG	PIK3CB	ENSG00000051382	-0.04992014283055418	[670]	[623,315,872,752]	-1	hSpCas9	negative selection	9442779
138755810	138755833	3	+	27260156	TC32	viability	CTTGTCACTAATTTGAGAACTGG	PIK3CB	ENSG00000051382	0.11601546426447151	[175]	[163,169,171,204]	2	hSpCas9	negative selection	9507029
138737753	138737776	3	-	27260156	TC32	viability	GATTATGTGTTGCAAGTCAGCGG	PIK3CB	ENSG00000051382	-0.17124808160639318	[559]	[440,403,518,514]	-3	hSpCas9	negative selection	9507030
138737702	138737725	3	+	27260156	TC32	viability	CATACCTGGAACTGAATTAGTGG	PIK3CB	ENSG00000051382	-0.5420648647092519	[691]	[486,347,539,430]	-8	hSpCas9	negative selection	9507031
138694851	138694874	3	+	27869803	HPAFII	viability after 27 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-3.179179545943124	[129]	[12,2,NaN]	-9	hSpCas9	negative selection	9582813
138707152	138707175	3	+	27869803	HPAFII	viability after 27 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-0.37053929312398926	[111]	[2,80,NaN]	-3	hSpCas9	negative selection	9582814
138712274	138712297	3	-	27869803	HPAFII	viability after 27 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	0.8471939014241292	[363]	[190,471,NaN]	7	hSpCas9	negative selection	9582815
138714475	138714498	3	-	27869803	HPAFII	viability after 27 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	1.0304704962654658	[288]	[347,278,NaN]	8	hSpCas9	negative selection	9582816
138755794	138755817	3	-	27869803	HPAFII	viability after 27 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.707932397329541	[432]	[230,62,NaN]	-5	hSpCas9	negative selection	9582817
138759283	138759306	3	-	27869803	HPAFII	viability after 27 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	1.431164306064257	[120]	[350,21,NaN]	9	hSpCas9	negative selection	9582818
138694851	138694874	3	+	27869803	HPAFII	viability after 15 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-0.9148235090981502	[129]	[136,34,NaN]	-7	hSpCas9	negative selection	9665262
138707152	138707175	3	+	27869803	HPAFII	viability after 15 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	0.40710581420807934	[111]	[121,182,NaN]	5	hSpCas9	negative selection	9665263
138712274	138712297	3	-	27869803	HPAFII	viability after 15 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	0.4738184847466427	[363]	[472,586,NaN]	5	hSpCas9	negative selection	9665264
138714475	138714498	3	-	27869803	HPAFII	viability after 15 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.7964988624989877	[288]	[573,517,NaN]	8	hSpCas9	negative selection	9665265
138755794	138755817	3	-	27869803	HPAFII	viability after 15 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.46653847647382474	[432]	[292,363,NaN]	-5	hSpCas9	negative selection	9665266
138759283	138759306	3	-	27869803	HPAFII	viability after 15 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	1.1897727183761633	[120]	[628,89,NaN]	9	hSpCas9	negative selection	9665267
138694851	138694874	3	+	27869803	ASPC1	viability after 36 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	0.6462063780417532	[434]	[280,65,340]	6	hSpCas9	negative selection	9747711
138707152	138707175	3	+	27869803	ASPC1	viability after 36 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	1.0564937985490706	[322]	[117,106,414]	8	hSpCas9	negative selection	9747712
138712274	138712297	3	-	27869803	ASPC1	viability after 36 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.5724791967240948	[918]	[213,305,142]	-5	hSpCas9	negative selection	9747713
138714475	138714498	3	-	27869803	ASPC1	viability after 36 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	-0.7537298469233962	[871]	[239,192,126]	-6	hSpCas9	negative selection	9747714
138755794	138755817	3	-	27869803	ASPC1	viability after 36 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.027538752402456734	[1058]	[247,449,369]	0	hSpCas9	negative selection	9747715
138759283	138759306	3	-	27869803	ASPC1	viability after 36 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	-0.004462016940712563	[589]	[559,109,29]	0	hSpCas9	negative selection	9747716
138694851	138694874	3	+	27869803	PATU8988S	viability after 35 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-1.0504037626878568	[436]	[75,93,NaN]	-7	hSpCas9	negative selection	9830160
138707152	138707175	3	+	27869803	PATU8988S	viability after 35 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	0.8171247840994731	[228]	[161,162,NaN]	8	hSpCas9	negative selection	9830161
138712274	138712297	3	-	27869803	PATU8988S	viability after 35 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	-0.2667993435573085	[807]	[260,279,NaN]	-3	hSpCas9	negative selection	9830162
138714475	138714498	3	-	27869803	PATU8988S	viability after 35 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	-0.5300580198335699	[729]	[250,155,NaN]	-5	hSpCas9	negative selection	9830163
138755794	138755817	3	-	27869803	PATU8988S	viability after 35 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.9275644015650961	[900]	[94,286,NaN]	-7	hSpCas9	negative selection	9830164
138759283	138759306	3	-	27869803	PATU8988S	viability after 35 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	1.2274448081092677	[446]	[220,622,NaN]	9	hSpCas9	negative selection	9830165
138694851	138694874	3	+	27869803	PATU8988S	viability after 31 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-0.8990903207277723	[436]	[81,107,NaN]	-7	hSpCas9	negative selection	9912609
138707152	138707175	3	+	27869803	PATU8988S	viability after 31 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	0.8422598445401932	[228]	[113,226,NaN]	8	hSpCas9	negative selection	9912610
138712274	138712297	3	-	27869803	PATU8988S	viability after 31 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	0.027392681857677292	[807]	[330,324,NaN]	0	hSpCas9	negative selection	9912611
138714475	138714498	3	-	27869803	PATU8988S	viability after 31 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	0.04569074954448055	[729]	[343,244,NaN]	0	hSpCas9	negative selection	9912612
138755794	138755817	3	-	27869803	PATU8988S	viability after 31 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.79165693907577	[900]	[119,318,NaN]	-7	hSpCas9	negative selection	9912613
138759283	138759306	3	-	27869803	PATU8988S	viability after 31 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	0.9178241602774171	[446]	[235,464,NaN]	8	hSpCas9	negative selection	9912614
138694851	138694874	3	+	27869803	HPAFII	viability after 35 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-2.3526165856076497	[129]	[18,5,NaN]	-8	hSpCas9	negative selection	9995058
138707152	138707175	3	+	27869803	HPAFII	viability after 35 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-0.994478752538202	[111]	[3,55,NaN]	-5	hSpCas9	negative selection	9995059
138712274	138712297	3	-	27869803	HPAFII	viability after 35 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	0.6812020939251866	[363]	[191,411,NaN]	4	hSpCas9	negative selection	9995060
138714475	138714498	3	-	27869803	HPAFII	viability after 35 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	1.5004845329629581	[288]	[317,521,NaN]	8	hSpCas9	negative selection	9995061
138755794	138755817	3	-	27869803	HPAFII	viability after 35 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-0.9216481279409158	[432]	[142,84,NaN]	-5	hSpCas9	negative selection	9995062
138759283	138759306	3	-	27869803	HPAFII	viability after 35 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	0.9209604988777356	[120]	[194,26,NaN]	6	hSpCas9	negative selection	9995063
138694851	138694874	3	+	27869803	HPAFII	viability after 31 days	AAGCTCTAGGGCCTCCCGGGGGG	PIK3CB	ENSG00000051382	-1.5941921685041751	[129]	[38,7,NaN]	-7	hSpCas9	negative selection	10077507
138707152	138707175	3	+	27869803	HPAFII	viability after 31 days	AGCTTACCTTATCGAAGGGAGGG	PIK3CB	ENSG00000051382	-0.9653150046119539	[111]	[2,63,NaN]	-6	hSpCas9	negative selection	10077508
138712274	138712297	3	-	27869803	HPAFII	viability after 31 days	TGTAGCGTGGGTAAATACGATGG	PIK3CB	ENSG00000051382	0.4279272486345299	[363]	[147,412,NaN]	3	hSpCas9	negative selection	10077509
138714475	138714498	3	-	27869803	HPAFII	viability after 31 days	TATCAGACCATCAGGAAAGCTGG	PIK3CB	ENSG00000051382	1.1700852354030626	[288]	[341,389,NaN]	8	hSpCas9	negative selection	10077510
138755794	138755817	3	-	27869803	HPAFII	viability after 31 days	TGACAAGAAGTTGTGACCCAGGG	PIK3CB	ENSG00000051382	-1.0731029736354096	[432]	[148,78,NaN]	-6	hSpCas9	negative selection	10077511
138759283	138759306	3	-	27869803	HPAFII	viability after 31 days	CATCCTTGACATCTGGGCGGTGG	PIK3CB	ENSG00000051382	0.935765582961182	[120]	[216,34,NaN]	7	hSpCas9	negative selection	10077512
138684722	138684745	3	-	28162770	P31FUJ	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.679734954335282	[152]	[287]	7	hSpCas9	negative selection	10211337
138759286	138759309	3	-	28162770	P31FUJ	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.324104011175802	[224]	[330]	3	hSpCas9	negative selection	10211338
138759212	138759235	3	+	28162770	P31FUJ	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	0.4795013355175583	[176]	[289]	5	hSpCas9	negative selection	10211339
138759183	138759206	3	+	28162770	P31FUJ	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-0.26842611414509987	[40]	[39]	-3	hSpCas9	negative selection	10211340
138684656	138684679	3	+	28162770	P31FUJ	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	0.7127500115632452	[26]	[51]	7	hSpCas9	negative selection	10211341
138755793	138755816	3	-	28162770	P31FUJ	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.357213524033063	[284]	[428]	4	hSpCas9	negative selection	10211342
138691066	138691089	3	+	28162770	P31FUJ	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	0.2418782412918669	[153]	[213]	2	hSpCas9	negative selection	10211343
138665139	138665162	3	+	28162770	P31FUJ	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	-0.8342528279241039	[219]	[144]	-6	hSpCas9	negative selection	10211344
138656249	138656272	3	+	28162770	P31FUJ	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	-0.05495412840006331	[342]	[387]	0	hSpCas9	negative selection	10211345
138759300	138759323	3	+	28162770	P31FUJ	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	0.4514882234334161	[462]	[743]	5	hSpCas9	negative selection	10211346
138684722	138684745	3	-	28162770	TF1	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	NaN	[NaN]	[249]	1	hSpCas9	negative selection	10380703
138759286	138759309	3	-	28162770	TF1	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	NaN	[NaN]	[351]	1	hSpCas9	negative selection	10380704
138759212	138759235	3	+	28162770	TF1	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	NaN	[NaN]	[102]	1	hSpCas9	negative selection	10380705
138759183	138759206	3	+	28162770	TF1	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	NaN	[NaN]	[52]	1	hSpCas9	negative selection	10380706
138684656	138684679	3	+	28162770	TF1	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	NaN	[NaN]	[1]	1	hSpCas9	negative selection	10380707
138755793	138755816	3	-	28162770	TF1	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	NaN	[NaN]	[297]	1	hSpCas9	negative selection	10380708
138691066	138691089	3	+	28162770	TF1	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	NaN	[NaN]	[157]	1	hSpCas9	negative selection	10380709
138665139	138665162	3	+	28162770	TF1	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	NaN	[NaN]	[133]	1	hSpCas9	negative selection	10380710
138656249	138656272	3	+	28162770	TF1	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	NaN	[NaN]	[276]	1	hSpCas9	negative selection	10380711
138759300	138759323	3	+	28162770	TF1	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	NaN	[NaN]	[444]	1	hSpCas9	negative selection	10380712
138684722	138684745	3	-	28162770	SKM1	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.6185708933639759	[48]	[132]	6	hSpCas9	negative selection	10550069
138759286	138759309	3	-	28162770	SKM1	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.49992639686535684	[59]	[149]	5	hSpCas9	negative selection	10550070
138759212	138759235	3	+	28162770	SKM1	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	-0.5875364443849824	[67]	[79]	-5	hSpCas9	negative selection	10550071
138759183	138759206	3	+	28162770	SKM1	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-1.8220016980220053	[5]	[2]	-8	hSpCas9	negative selection	10550072
138684656	138684679	3	+	28162770	SKM1	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	1.084888897586513	[3]	[14]	8	hSpCas9	negative selection	10550073
138755793	138755816	3	-	28162770	SKM1	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.09434037293108499	[70]	[133]	0	hSpCas9	negative selection	10550074
138691066	138691089	3	+	28162770	SKM1	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	1.0848888975865132	[31]	[119]	8	hSpCas9	negative selection	10550075
138665139	138665162	3	+	28162770	SKM1	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	0.06478769153000363	[52]	[97]	0	hSpCas9	negative selection	10550076
138656249	138656272	3	+	28162770	SKM1	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	-0.2625742894079868	[94]	[139]	-2	hSpCas9	negative selection	10550077
138759300	138759323	3	+	28162770	SKM1	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	-0.08719098855947327	[133]	[222]	0	hSpCas9	negative selection	10550078
138684722	138684745	3	-	28162770	SKM1	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.6185708933639759	[48]	[132]	6	hSpCas9	negative selection	10719435
138759286	138759309	3	-	28162770	SKM1	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.49992639686535684	[59]	[149]	5	hSpCas9	negative selection	10719436
138759212	138759235	3	+	28162770	SKM1	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	-0.5875364443849824	[67]	[79]	-5	hSpCas9	negative selection	10719437
138759183	138759206	3	+	28162770	SKM1	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-1.8220016980220053	[5]	[2]	-8	hSpCas9	negative selection	10719438
138684656	138684679	3	+	28162770	SKM1	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	1.084888897586513	[3]	[14]	8	hSpCas9	negative selection	10719439
138755793	138755816	3	-	28162770	SKM1	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.09434037293108499	[70]	[133]	0	hSpCas9	negative selection	10719440
138691066	138691089	3	+	28162770	SKM1	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	1.0848888975865132	[31]	[119]	8	hSpCas9	negative selection	10719441
138665139	138665162	3	+	28162770	SKM1	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	0.06478769153000363	[52]	[97]	0	hSpCas9	negative selection	10719442
138656249	138656272	3	+	28162770	SKM1	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	-0.2625742894079868	[94]	[139]	-2	hSpCas9	negative selection	10719443
138759300	138759323	3	+	28162770	SKM1	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	-0.08719098855947327	[133]	[222]	0	hSpCas9	negative selection	10719444
138684722	138684745	3	-	28162770	PL21	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	-0.16360865609266925	[174]	[67]	-1	hSpCas9	negative selection	10888801
138759286	138759309	3	-	28162770	PL21	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	1.767824123778641	[223]	[331]	9	hSpCas9	negative selection	10888802
138759212	138759235	3	+	28162770	PL21	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	1.1678992774891122	[180]	[176]	8	hSpCas9	negative selection	10888803
138759183	138759206	3	+	28162770	PL21	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-0.9153376029306166	[12]	[2]	-6	hSpCas9	negative selection	10888804
138684656	138684679	3	+	28162770	PL21	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	-2.384822886231836	[11]	[0]	-8	hSpCas9	negative selection	10888805
138755793	138755816	3	-	28162770	PL21	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.484257621617993	[316]	[192]	4	hSpCas9	negative selection	10888806
138691066	138691089	3	+	28162770	PL21	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	-0.2676393468614968	[129]	[46]	-2	hSpCas9	negative selection	10888807
138665139	138665162	3	+	28162770	PL21	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	0.20013961448932016	[167]	[83]	1	hSpCas9	negative selection	10888808
138656249	138656272	3	+	28162770	PL21	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	-0.5812200990353396	[274]	[79]	-4	hSpCas9	negative selection	10888809
138759300	138759323	3	+	28162770	PL21	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	0.11897676159471926	[456]	[215]	1	hSpCas9	negative selection	10888810
138684722	138684745	3	-	28162770	P31FUJ	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.679734954335282	[152]	[287]	7	hSpCas9	negative selection	11058167
138759286	138759309	3	-	28162770	P31FUJ	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.324104011175802	[224]	[330]	3	hSpCas9	negative selection	11058168
138759212	138759235	3	+	28162770	P31FUJ	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	0.4795013355175583	[176]	[289]	5	hSpCas9	negative selection	11058169
138759183	138759206	3	+	28162770	P31FUJ	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-0.26842611414509987	[40]	[39]	-3	hSpCas9	negative selection	11058170
138684656	138684679	3	+	28162770	P31FUJ	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	0.7127500115632452	[26]	[51]	7	hSpCas9	negative selection	11058171
138755793	138755816	3	-	28162770	P31FUJ	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.357213524033063	[284]	[428]	4	hSpCas9	negative selection	11058172
138691066	138691089	3	+	28162770	P31FUJ	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	0.2418782412918669	[153]	[213]	2	hSpCas9	negative selection	11058173
138665139	138665162	3	+	28162770	P31FUJ	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	-0.8342528279241039	[219]	[144]	-6	hSpCas9	negative selection	11058174
138656249	138656272	3	+	28162770	P31FUJ	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	-0.05495412840006331	[342]	[387]	0	hSpCas9	negative selection	11058175
138759300	138759323	3	+	28162770	P31FUJ	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	0.4514882234334161	[462]	[743]	5	hSpCas9	negative selection	11058176
138684722	138684745	3	-	28162770	OCIAML5	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.6796539085801797	[137]	[398]	6	hSpCas9	negative selection	11227533
138759286	138759309	3	-	28162770	OCIAML5	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.8266538822662558	[138]	[444]	7	hSpCas9	negative selection	11227534
138759212	138759235	3	+	28162770	OCIAML5	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	0.5729550169874691	[107]	[289]	5	hSpCas9	negative selection	11227535
138759183	138759206	3	+	28162770	OCIAML5	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	1.848373147277095	[7]	[51]	9	hSpCas9	negative selection	11227536
138684656	138684679	3	+	28162770	OCIAML5	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	2.3178584305783154	[8]	[80]	9	hSpCas9	negative selection	11227537
138755793	138755816	3	-	28162770	OCIAML5	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.7025222808136403	[127]	[375]	6	hSpCas9	negative selection	11227538
138691066	138691089	3	+	28162770	OCIAML5	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	0.45244447094595613	[99]	[246]	4	hSpCas9	negative selection	11227539
138665139	138665162	3	+	28162770	OCIAML5	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	0.7063017198454459	[72]	[214]	6	hSpCas9	negative selection	11227540
138656249	138656272	3	+	28162770	OCIAML5	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	0.8910437635231181	[163]	[548]	7	hSpCas9	negative selection	11227541
138759300	138759323	3	+	28162770	OCIAML5	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	-0.10756730401238324	[381]	[639]	-1	hSpCas9	negative selection	11227542
138684722	138684745	3	-	28162770	EOL1	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.563800427792644	[338]	[263]	5	hSpCas9	negative selection	11396899
138759286	138759309	3	-	28162770	EOL1	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	1.0506275199501098	[218]	[238]	8	hSpCas9	negative selection	11396900
138759212	138759235	3	+	28162770	EOL1	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	1.7281111144657646	[380]	[664]	9	hSpCas9	negative selection	11396901
138759183	138759206	3	+	28162770	EOL1	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	0.900701029616167	[60]	[59]	7	hSpCas9	negative selection	11396902
138684656	138684679	3	+	28162770	EOL1	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	-1.4904897277083093	[31]	[5]	-7	hSpCas9	negative selection	11396903
138755793	138755816	3	-	28162770	EOL1	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.444095759815585	[578]	[414]	4	hSpCas9	negative selection	11396904
138691066	138691089	3	+	28162770	EOL1	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	0.026797829818484997	[176]	[94]	0	hSpCas9	negative selection	11396905
138665139	138665162	3	+	28162770	EOL1	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	-0.5425782388567635	[234]	[84]	-4	hSpCas9	negative selection	11396906
138656249	138656272	3	+	28162770	EOL1	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	1.0541074053394506	[297]	[325]	8	hSpCas9	negative selection	11396907
138759300	138759323	3	+	28162770	EOL1	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	1.0906116102086814	[581]	[652]	8	hSpCas9	negative selection	11396908
138684722	138684745	3	-	28162770	MOLM13	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	-0.37275485872329617	[273]	[152]	-2	hSpCas9	negative selection	11566265
138759286	138759309	3	-	28162770	MOLM13	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	-0.9877901022316109	[383]	[139]	-5	hSpCas9	negative selection	11566266
138759212	138759235	3	+	28162770	MOLM13	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	0.9802832563150902	[264]	[377]	7	hSpCas9	negative selection	11566267
138759183	138759206	3	+	28162770	MOLM13	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-0.5935111631195644	[47]	[22]	-3	hSpCas9	negative selection	11566268
138684656	138684679	3	+	28162770	MOLM13	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	-2.254576642926512	[32]	[4]	-7	hSpCas9	negative selection	11566269
138755793	138755816	3	-	28162770	MOLM13	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.533033406864089	[432]	[452]	4	hSpCas9	negative selection	11566270
138691066	138691089	3	+	28162770	MOLM13	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	-1.7899083759230676	[219]	[45]	-7	hSpCas9	negative selection	11566271
138665139	138665162	3	+	28162770	MOLM13	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	-0.7104478597139336	[257]	[113]	-4	hSpCas9	negative selection	11566272
138656249	138656272	3	+	28162770	MOLM13	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	0.09222612059987934	[505]	[389]	0	hSpCas9	negative selection	11566273
138759300	138759323	3	+	28162770	MOLM13	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	0.6826528654716948	[622]	[722]	5	hSpCas9	negative selection	11566274
138684722	138684745	3	-	28162770	HEL	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.5025611739520964	[215]	[195]	4	hSpCas9	negative selection	11735631
138759286	138759309	3	-	28162770	HEL	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.025145327039234222	[312]	[203]	0	hSpCas9	negative selection	11735632
138759212	138759235	3	+	28162770	HEL	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	0.04007432954574189	[204]	[134]	0	hSpCas9	negative selection	11735633
138759183	138759206	3	+	28162770	HEL	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-3.642663386861891	[38]	[1]	-9	hSpCas9	negative selection	11735634
138684656	138684679	3	+	28162770	HEL	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	-3.4447240092499825	[16]	[0]	-9	hSpCas9	negative selection	11735635
138755793	138755816	3	-	28162770	HEL	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	-0.37904985676492964	[466]	[229]	-3	hSpCas9	negative selection	11735636
138691066	138691089	3	+	28162770	HEL	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	-1.4821524158274517	[204]	[46]	-7	hSpCas9	negative selection	11735637
138665139	138665162	3	+	28162770	HEL	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	-0.4276504958910411	[167]	[79]	-3	hSpCas9	negative selection	11735638
138656249	138656272	3	+	28162770	HEL	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	-0.6282883645869675	[361]	[149]	-4	hSpCas9	negative selection	11735639
138759300	138759323	3	+	28162770	HEL	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	0.37814391217894605	[554]	[461]	3	hSpCas9	negative selection	11735640
138684722	138684745	3	-	28162770	MV411	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.5426352800556159	[206]	[253]	5	hSpCas9	negative selection	11904997
138759286	138759309	3	-	28162770	MV411	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	-0.1076574080397864	[219]	[171]	-1	hSpCas9	negative selection	11904998
138759212	138759235	3	+	28162770	MV411	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	0.3163326319938428	[183]	[192]	3	hSpCas9	negative selection	11904999
138759183	138759206	3	+	28162770	MV411	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-2.1931350406032064	[37]	[6]	-8	hSpCas9	negative selection	11905000
138684656	138684679	3	+	28162770	MV411	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	-4.00048996266081	[18]	[0]	-9	hSpCas9	negative selection	11905001
138755793	138755816	3	-	28162770	MV411	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.5876664624130814	[281]	[356]	5	hSpCas9	negative selection	11905002
138691066	138691089	3	+	28162770	MV411	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	-0.5869763834992496	[147]	[82]	-4	hSpCas9	negative selection	11905003
138665139	138665162	3	+	28162770	MV411	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	0.919862892754271	[127]	[203]	8	hSpCas9	negative selection	11905004
138656249	138656272	3	+	28162770	MV411	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	0.35894586599976563	[223]	[241]	3	hSpCas9	negative selection	11905005
138759300	138759323	3	+	28162770	MV411	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	-0.061751432273909446	[450]	[363]	0	hSpCas9	negative selection	11905006
138684722	138684745	3	-	28162770	MONOMAC1	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	-0.5428116839012838	[121]	[95]	-4	hSpCas9	negative selection	12074363
138759286	138759309	3	-	28162770	MONOMAC1	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	-0.35976634709766203	[149]	[133]	-3	hSpCas9	negative selection	12074364
138759212	138759235	3	+	28162770	MONOMAC1	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	0.37450513789928097	[143]	[213]	4	hSpCas9	negative selection	12074365
138759183	138759206	3	+	28162770	MONOMAC1	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-0.8889145516972219	[20]	[12]	-6	hSpCas9	negative selection	12074366
138684656	138684679	3	+	28162770	MONOMAC1	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	1.4659281656628758	[11]	[37]	9	hSpCas9	negative selection	12074367
138755793	138755816	3	-	28162770	MONOMAC1	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.22798474079191233	[215]	[289]	2	hSpCas9	negative selection	12074368
138691066	138691089	3	+	28162770	MONOMAC1	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	-0.26829553022937547	[82]	[78]	-2	hSpCas9	negative selection	12074369
138665139	138665162	3	+	28162770	MONOMAC1	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	0.5087800485359881	[102]	[167]	5	hSpCas9	negative selection	12074370
138656249	138656272	3	+	28162770	MONOMAC1	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	-0.05071845856957541	[177]	[196]	0	hSpCas9	negative selection	12074371
138759300	138759323	3	+	28162770	MONOMAC1	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	0.1676271297041707	[305]	[393]	1	hSpCas9	negative selection	12074372
138684722	138684745	3	-	28162770	OCIAML2	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	0.4553695933140618	[24]	[189]	4	hSpCas9	negative selection	12243729
138759286	138759309	3	-	28162770	OCIAML2	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.5293701747578387	[42]	[343]	5	hSpCas9	negative selection	12243730
138759212	138759235	3	+	28162770	OCIAML2	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	0.4516908109359632	[30]	[234]	4	hSpCas9	negative selection	12243731
138759183	138759206	3	+	28162770	OCIAML2	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	-0.30070482379984886	[3]	[17]	-2	hSpCas9	negative selection	12243732
138684656	138684679	3	+	28162770	OCIAML2	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	-2.470629825242161	[4]	[4]	-8	hSpCas9	negative selection	12243733
138755793	138755816	3	-	28162770	OCIAML2	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	-0.3340248969998755	[72]	[320]	-3	hSpCas9	negative selection	12243734
138691066	138691089	3	+	28162770	OCIAML2	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	-0.4851293949372764	[24]	[98]	-4	hSpCas9	negative selection	12243735
138665139	138665162	3	+	28162770	OCIAML2	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	0.7052200101572564	[26]	[243]	7	hSpCas9	negative selection	12243736
138656249	138656272	3	+	28162770	OCIAML2	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	0.4813486598948954	[41]	[324]	4	hSpCas9	negative selection	12243737
138759300	138759323	3	+	28162770	OCIAML2	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	0.0702101222466871	[82]	[482]	0	hSpCas9	negative selection	12243738
138684722	138684745	3	-	28162770	OCIAML3	viability	GTTAAACAGAGCCAAAGGGAAGG	PIK3CB	ENSG00000051382	-0.08093805808479274	[47]	[136]	0	hSpCas9	negative selection	12413095
138759286	138759309	3	-	28162770	OCIAML3	viability	AGACATCCTTGACATCTGGGCGG	PIK3CB	ENSG00000051382	0.544474313467268	[66]	[294]	5	hSpCas9	negative selection	12413096
138759212	138759235	3	+	28162770	OCIAML3	viability	CAACTGGATATAAATCCCAGTGG	PIK3CB	ENSG00000051382	-0.8097363313796002	[71]	[123]	-6	hSpCas9	negative selection	12413097
138759183	138759206	3	+	28162770	OCIAML3	viability	TAAGAAATGGTAGCTTCCCGAGG	PIK3CB	ENSG00000051382	1.0498485494505616	[7]	[49]	8	hSpCas9	negative selection	12413098
138684656	138684679	3	+	28162770	OCIAML3	viability	GGGGTGACTGCAGGTCAGAGAGG	PIK3CB	ENSG00000051382	-1.079434467494405	[6]	[9]	-6	hSpCas9	negative selection	12413099
138755793	138755816	3	-	28162770	OCIAML3	viability	GACAAGAAGTTGTGACCCAGGGG	PIK3CB	ENSG00000051382	0.12153897020713722	[94]	[311]	1	hSpCas9	negative selection	12413100
138691066	138691089	3	+	28162770	OCIAML3	viability	GAGAGGGCACAATCAAGAAAAGG	PIK3CB	ENSG00000051382	-1.027660817770354	[51]	[76]	-6	hSpCas9	negative selection	12413101
138665139	138665162	3	+	28162770	OCIAML3	viability	AGGTGCTCACAACTTCAATGAGG	PIK3CB	ENSG00000051382	-0.4036764282200136	[38]	[88]	-3	hSpCas9	negative selection	12413102
138656249	138656272	3	+	28162770	OCIAML3	viability	ATGCATCCTCACAACACTGGCGG	PIK3CB	ENSG00000051382	-0.9419309437444701	[69]	[109]	-6	hSpCas9	negative selection	12413103
138759300	138759323	3	+	28162770	OCIAML3	viability	AGGATGTCTGCCATAGCAGGAGG	PIK3CB	ENSG00000051382	0.06565222767459433	[137]	[435]	0	hSpCas9	negative selection	12413104