Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 80339
• Symbol: PNPLA3
• Description: patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase

DataSource: http://genomecrispr.dkfz.de/#!/results/PNPLA3

Export (tab separated) Export to Excel

Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
43923943	43923966	22	-	26472758	Jiyoye	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	0.16984668986455453	[177]	[150]	1	hSpCas9	negative selection	123126
43932872	43932895	22	+	26472758	Jiyoye	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.042071145416729294	[406]	[315]	0	hSpCas9	negative selection	123127
43924019	43924042	22	-	26472758	Jiyoye	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	0.08524728661851104	[119]	[95]	0	hSpCas9	negative selection	123128
43933030	43933053	22	-	26472758	Jiyoye	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.829199311100824	[102]	[137]	6	hSpCas9	negative selection	123129
43937079	43937102	22	+	26472758	Jiyoye	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	0.9183365818169131	[126]	[180]	6	hSpCas9	negative selection	123130
43937220	43937243	22	-	26472758	Jiyoye	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	0.19567127631216152	[21]	[18]	1	hSpCas9	negative selection	123131
43923909	43923932	22	+	26472758	Jiyoye	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-0.23025453910941818	[335]	[215]	-2	hSpCas9	negative selection	123132
43923989	43924012	22	-	26472758	Jiyoye	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	0.009415873658865315	[82]	[62]	0	hSpCas9	negative selection	123133
43927050	43927073	22	-	26472758	Jiyoye	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	-0.07243411906905417	[98]	[70]	0	hSpCas9	negative selection	123134
43928825	43928848	22	-	26472758	Jiyoye	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-1.650540116350414	[203]	[48]	-8	hSpCas9	negative selection	123135
43923943	43923966	22	-	26472758	KBM7	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	0.6443309915169555	[527,250]	[338,221]	7	hSpCas9	negative selection	314244
43932872	43932895	22	+	26472758	KBM7	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.7266539274653478	[1514,1209]	[1314,818]	7	hSpCas9	negative selection	314245
43924019	43924042	22	-	26472758	KBM7	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	-0.042365496696859406	[486,236]	[164,155]	0	hSpCas9	negative selection	314246
43933030	43933053	22	-	26472758	KBM7	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	-0.23539761112351476	[736,382]	[235,200]	-2	hSpCas9	negative selection	314247
43937079	43937102	22	+	26472758	KBM7	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	0.5024758013697972	[747,618]	[592,327]	5	hSpCas9	negative selection	314248
43937220	43937243	22	-	26472758	KBM7	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	-0.3238585089283317	[209,154]	[70,64]	-3	hSpCas9	negative selection	314249
43923909	43923932	22	+	26472758	KBM7	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.21495048428967278	[1144,1347]	[920,481]	2	hSpCas9	negative selection	314250
43923989	43924012	22	-	26472758	KBM7	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	0.33310585120373026	[407,275]	[122,267]	3	hSpCas9	negative selection	314251
43927050	43927073	22	-	26472758	KBM7	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	0.4927819094056726	[439,207]	[196,216]	5	hSpCas9	negative selection	314252
43928825	43928848	22	-	26472758	KBM7	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.6775926271022963	[377,459]	[351,290]	7	hSpCas9	negative selection	314253
43923943	43923966	22	-	26472758	Raji	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	0.09541089370752347	[241]	[59]	0	hSpCas9	negative selection	505362
43932872	43932895	22	+	26472758	Raji	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.8093021824406048	[599]	[243]	7	hSpCas9	negative selection	505363
43924019	43924042	22	-	26472758	Raji	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	-0.15180880416580017	[224]	[46]	-1	hSpCas9	negative selection	505364
43933030	43933053	22	-	26472758	Raji	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.46470553679615584	[305]	[97]	4	hSpCas9	negative selection	505365
43937079	43937102	22	+	26472758	Raji	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	0.636636603508468	[351]	[126]	6	hSpCas9	negative selection	505366
43937220	43937243	22	-	26472758	Raji	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	-1.292547071515036	[94]	[8]	-7	hSpCas9	negative selection	505367
43923909	43923932	22	+	26472758	Raji	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.7066883552538943	[366]	[138]	6	hSpCas9	negative selection	505368
43923989	43924012	22	-	26472758	Raji	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	-0.24809711922478955	[173]	[33]	-2	hSpCas9	negative selection	505369
43927050	43927073	22	-	26472758	Raji	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	0.9000585621260933	[126]	[54]	7	hSpCas9	negative selection	505370
43928825	43928848	22	-	26472758	Raji	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.6314637939477333	[241]	[86]	6	hSpCas9	negative selection	505371
43923943	43923966	22	-	26472758	K562	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	-0.05991530720617719	[325]	[263]	0	hSpCas9	negative selection	696480
43932872	43932895	22	+	26472758	K562	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.9000641151447788	[1247]	[1965]	7	hSpCas9	negative selection	696481
43924019	43924042	22	-	26472758	K562	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	1.5138794026596738	[223]	[539]	9	hSpCas9	negative selection	696482
43933030	43933053	22	-	26472758	K562	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	-0.38470358597299276	[480]	[310]	-3	hSpCas9	negative selection	696483
43937079	43937102	22	+	26472758	K562	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	1.1570399963150315	[535]	[1008]	8	hSpCas9	negative selection	696484
43937220	43937243	22	-	26472758	K562	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	0.5712290439335552	[176]	[221]	4	hSpCas9	negative selection	696485
43923909	43923932	22	+	26472758	K562	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	1.0724193979862757	[782]	[1389]	8	hSpCas9	negative selection	696486
43923989	43924012	22	-	26472758	K562	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	-0.08815661142042408	[271]	[215]	0	hSpCas9	negative selection	696487
43927050	43927073	22	-	26472758	K562	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	-0.22386079288937633	[183]	[132]	-1	hSpCas9	negative selection	696488
43928825	43928848	22	-	26472758	K562	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-0.40613211468228605	[404]	[257]	-3	hSpCas9	negative selection	696489
43923909	43923932	22	+	26627737	DLD1	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.4672292737917427	[1150]	[336,893,307]	5	hSpCas9	negative selection	818206
43927015	43927038	22	+	26627737	DLD1	viability	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.31560138747763045	[1061]	[249,507,475]	3	hSpCas9	negative selection	818207
43928869	43928892	22	-	26627737	DLD1	viability	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-0.05850618527009521	[132]	[55,22,39]	0	hSpCas9	negative selection	818208
43933073	43933096	22	-	26627737	DLD1	viability	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.6382446802318136	[699]	[77,143,191]	-6	hSpCas9	negative selection	818209
43937120	43937143	22	-	26627737	DLD1	viability	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	-0.04645031775982851	[454]	[142,184,93]	0	hSpCas9	negative selection	818210
43940104	43940127	22	+	26627737	DLD1	viability	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	0.036804951724967006	[833]	[258,277,265]	0	hSpCas9	negative selection	818211
43923909	43923932	22	+	26627737	GBM cells	viability after 5 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-0.07896331421617431	[452]	[197,261]	-1	hSpCas9	negative selection	900521
43927015	43927038	22	+	26627737	GBM cells	viability after 5 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.07275077812685349	[604]	[312,303]	-1	hSpCas9	negative selection	900522
43928869	43928892	22	-	26627737	GBM cells	viability after 5 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	0.7233423103022313	[95]	[82,86]	8	hSpCas9	negative selection	900523
43933073	43933096	22	-	26627737	GBM cells	viability after 5 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.04622419007979617	[386]	[220,180]	0	hSpCas9	negative selection	900524
43937120	43937143	22	-	26627737	GBM cells	viability after 5 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	0.3436987175585813	[215]	[116,176]	5	hSpCas9	negative selection	900525
43940104	43940127	22	+	26627737	GBM cells	viability after 5 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.22493220607140674	[388]	[236,119]	-4	hSpCas9	negative selection	900526
43923909	43923932	22	+	26627737	GBM cells	viability after 13 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-0.08250601653236678	[452]	[203,254]	-1	hSpCas9	negative selection	982836
43927015	43927038	22	+	26627737	GBM cells	viability after 13 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.08324835612918036	[604]	[289,325]	-1	hSpCas9	negative selection	982837
43928869	43928892	22	-	26627737	GBM cells	viability after 13 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-0.3007250960037413	[95]	[65,22]	-4	hSpCas9	negative selection	982838
43933073	43933096	22	-	26627737	GBM cells	viability after 13 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.16832717001551417	[386]	[241,141]	-2	hSpCas9	negative selection	982839
43937120	43937143	22	-	26627737	GBM cells	viability after 13 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	-0.11760223840543818	[215]	[80,129]	-1	hSpCas9	negative selection	982840
43940104	43940127	22	+	26627737	GBM cells	viability after 13 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.48867909239792384	[388]	[161,140]	-5	hSpCas9	negative selection	982841
43923909	43923932	22	+	26627737	GBM cells	viability after 21 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-0.03524182097698525	[452]	[247,232]	0	hSpCas9	negative selection	1065151
43927015	43927038	22	+	26627737	GBM cells	viability after 21 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.3567756669073945	[604]	[434,407]	3	hSpCas9	negative selection	1065152
43928869	43928892	22	-	26627737	GBM cells	viability after 21 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	0.23830650909522344	[95]	[60,61]	2	hSpCas9	negative selection	1065153
43933073	43933096	22	-	26627737	GBM cells	viability after 21 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.25488634249570047	[386]	[194,158]	-2	hSpCas9	negative selection	1065154
43937120	43937143	22	-	26627737	GBM cells	viability after 21 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	-0.17067374892189732	[215]	[109,98]	-1	hSpCas9	negative selection	1065155
43940104	43940127	22	+	26627737	GBM cells	viability after 21 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.23029371396784143	[388]	[199,161]	-2	hSpCas9	negative selection	1065156
43923909	43923932	22	+	26627737	RPE1	viability after 9 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.8132212568000003	[1150]	[623,644]	5	hSpCas9	negative selection	1147466
43927015	43927038	22	+	26627737	RPE1	viability after 9 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.9045256181403252	[1694]	[179,416]	-6	hSpCas9	negative selection	1147467
43928869	43928892	22	-	26627737	RPE1	viability after 9 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-0.6539828593969995	[735]	[207,66]	-5	hSpCas9	negative selection	1147468
43933073	43933096	22	-	26627737	RPE1	viability after 9 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-1.189104387633041	[1256]	[186,153]	-7	hSpCas9	negative selection	1147469
43937120	43937143	22	-	26627737	RPE1	viability after 9 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	1.9486409832338978	[656]	[717,891]	8	hSpCas9	negative selection	1147470
43940104	43940127	22	+	26627737	RPE1	viability after 9 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	0.8651440182575781	[746]	[511,314]	5	hSpCas9	negative selection	1147471
43923909	43923932	22	+	26627737	RPE1	viability after 12 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	1.0854938918031227	[1150]	[731,575]	6	hSpCas9	negative selection	1229781
43927015	43927038	22	+	26627737	RPE1	viability after 12 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.2229938202677968	[1694]	[259,527]	-1	hSpCas9	negative selection	1229782
43928869	43928892	22	-	26627737	RPE1	viability after 12 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-1.0480807256423121	[735]	[133,54]	-6	hSpCas9	negative selection	1229783
43933073	43933096	22	-	26627737	RPE1	viability after 12 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.9726739961093436	[1256]	[140,204]	-6	hSpCas9	negative selection	1229784
43937120	43937143	22	-	26627737	RPE1	viability after 12 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	1.5782556320576135	[656]	[444,613]	8	hSpCas9	negative selection	1229785
43940104	43940127	22	+	26627737	RPE1	viability after 12 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	0.5283529266675671	[746]	[253,326]	3	hSpCas9	negative selection	1229786
43923909	43923932	22	+	26627737	RPE1	viability after 15 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	1.3134881552523592	[1150]	[992,631]	7	hSpCas9	negative selection	1312096
43927015	43927038	22	+	26627737	RPE1	viability after 15 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.2951225624609839	[1694]	[318,459]	-2	hSpCas9	negative selection	1312097
43928869	43928892	22	-	26627737	RPE1	viability after 15 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-2.1113530423715745	[735]	[65,30]	-8	hSpCas9	negative selection	1312098
43933073	43933096	22	-	26627737	RPE1	viability after 15 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-2.036263281648795	[1256]	[47,123]	-8	hSpCas9	negative selection	1312099
43937120	43937143	22	-	26627737	RPE1	viability after 15 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	1.5199052997593099	[656]	[590,476]	7	hSpCas9	negative selection	1312100
43940104	43940127	22	+	26627737	RPE1	viability after 15 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	0.17280856291393448	[746]	[226,248]	1	hSpCas9	negative selection	1312101
43923909	43923932	22	+	26627737	RPE1	viability after 18 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	1.669695517531225	[1150]	[1023,949]	8	hSpCas9	negative selection	1394411
43927015	43927038	22	+	26627737	RPE1	viability after 18 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.0670371403760952	[1694]	[265,706]	0	hSpCas9	negative selection	1394412
43928869	43928892	22	-	26627737	RPE1	viability after 18 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-1.6887688818602764	[735]	[93,26]	-7	hSpCas9	negative selection	1394413
43933073	43933096	22	-	26627737	RPE1	viability after 18 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-1.1018439819378334	[1256]	[144,171]	-6	hSpCas9	negative selection	1394414
43937120	43937143	22	-	26627737	RPE1	viability after 18 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	1.6583101351046772	[656]	[432,694]	8	hSpCas9	negative selection	1394415
43940104	43940127	22	+	26627737	RPE1	viability after 18 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.04268093530170987	[746]	[201,188]	0	hSpCas9	negative selection	1394416
43923909	43923932	22	+	26627737	HeLa	viability after 8 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.2597882963313223	[718]	[278,304,508]	2	hSpCas9	negative selection	1476726
43927015	43927038	22	+	26627737	HeLa	viability after 8 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.24937208767847274	[533]	[348,209,284]	2	hSpCas9	negative selection	1476727
43928869	43928892	22	-	26627737	HeLa	viability after 8 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-1.0328097034140225	[266]	[64,47,58]	-8	hSpCas9	negative selection	1476728
43933073	43933096	22	-	26627737	HeLa	viability after 8 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.7072765984988678	[336]	[133,126,22]	-6	hSpCas9	negative selection	1476729
43937120	43937143	22	-	26627737	HeLa	viability after 8 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	0.026944586139594495	[346]	[165,185,114]	0	hSpCas9	negative selection	1476730
43940104	43940127	22	+	26627737	HeLa	viability after 8 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.08209840280665465	[511]	[321,153,181]	0	hSpCas9	negative selection	1476731
43923909	43923932	22	+	26627737	HeLa	viability after 12 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.478313308812625	[718]	[422,480,330]	4	hSpCas9	negative selection	1559041
43927015	43927038	22	+	26627737	HeLa	viability after 12 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.15729874581762704	[533]	[311,219,210]	1	hSpCas9	negative selection	1559042
43928869	43928892	22	-	26627737	HeLa	viability after 12 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-0.6857389772475689	[266]	[3,114,79]	-6	hSpCas9	negative selection	1559043
43933073	43933096	22	-	26627737	HeLa	viability after 12 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.3829991695696794	[336]	[123,152,38]	-3	hSpCas9	negative selection	1559044
43937120	43937143	22	-	26627737	HeLa	viability after 12 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	0.6745165931509943	[346]	[137,209,337]	5	hSpCas9	negative selection	1559045
43940104	43940127	22	+	26627737	HeLa	viability after 12 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.6984340489374588	[511]	[88,148,149]	-6	hSpCas9	negative selection	1559046
43923909	43923932	22	+	26627737	HeLa	viability after 15 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.7582288087803555	[718]	[780,453,225]	6	hSpCas9	negative selection	1641356
43927015	43927038	22	+	26627737	HeLa	viability after 15 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.0029626858524887667	[533]	[192,228,232]	0	hSpCas9	negative selection	1641357
43928869	43928892	22	-	26627737	HeLa	viability after 15 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-1.2667826125450183	[266]	[9,7,123]	-8	hSpCas9	negative selection	1641358
43933073	43933096	22	-	26627737	HeLa	viability after 15 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.772257793887478	[336]	[101,90,44]	-6	hSpCas9	negative selection	1641359
43937120	43937143	22	-	26627737	HeLa	viability after 15 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	1.0245235351988218	[346]	[231,425,197]	7	hSpCas9	negative selection	1641360
43940104	43940127	22	+	26627737	HeLa	viability after 15 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.738609954937775	[511]	[139,43,195]	-6	hSpCas9	negative selection	1641361
43923909	43923932	22	+	26627737	HeLa	viability after 18 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.7844091323127684	[718]	[539,377,225]	6	hSpCas9	negative selection	1723671
43927015	43927038	22	+	26627737	HeLa	viability after 18 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.02997655226131607	[533]	[133,193,232]	0	hSpCas9	negative selection	1723672
43928869	43928892	22	-	26627737	HeLa	viability after 18 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-1.2408944505825756	[266]	[7,6,123]	-8	hSpCas9	negative selection	1723673
43933073	43933096	22	-	26627737	HeLa	viability after 18 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.7243021116909691	[336]	[69,79,44]	-6	hSpCas9	negative selection	1723674
43937120	43937143	22	-	26627737	HeLa	viability after 18 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	0.9723455545561094	[346]	[145,339,197]	7	hSpCas9	negative selection	1723675
43940104	43940127	22	+	26627737	HeLa	viability after 18 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.69695522031851	[511]	[98,38,195]	-6	hSpCas9	negative selection	1723676
43923909	43923932	22	+	26627737	HCT116	viability after 6 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-1.7642144802583413	[2178]	[105,97]	-7	hSpCas9	negative selection	1805986
43927015	43927038	22	+	26627737	HCT116	viability after 6 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.4002156037304013	[1518]	[227,154]	-2	hSpCas9	negative selection	1805987
43928869	43928892	22	-	26627737	HCT116	viability after 6 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	0.9973049110873051	[169]	[82,36]	5	hSpCas9	negative selection	1805988
43933073	43933096	22	-	26627737	HCT116	viability after 6 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-2.073255920896601	[1738]	[160,11]	-8	hSpCas9	negative selection	1805989
43937120	43937143	22	-	26627737	HCT116	viability after 6 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	-2.5026301785386207	[462]	[17,9]	-8	hSpCas9	negative selection	1805990
43940104	43940127	22	+	26627737	HCT116	viability after 6 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	1.506768225207566	[430]	[256,156]	7	hSpCas9	negative selection	1805991
43923909	43923932	22	+	26627737	HCT116	viability after 8 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.12565873038140718	[541]	[289,371,314]	1	hSpCas9	negative selection	1888301
43927015	43927038	22	+	26627737	HCT116	viability after 8 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.5464239027754023	[807]	[319,385,209]	-6	hSpCas9	negative selection	1888302
43928869	43928892	22	-	26627737	HCT116	viability after 8 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-0.9150116678902545	[197]	[18,104,48]	-8	hSpCas9	negative selection	1888303
43933073	43933096	22	-	26627737	HCT116	viability after 8 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.5254916084470262	[408]	[266,156,48]	-6	hSpCas9	negative selection	1888304
43937120	43937143	22	-	26627737	HCT116	viability after 8 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	0.7682108784465872	[184]	[109,258,150]	7	hSpCas9	negative selection	1888305
43940104	43940127	22	+	26627737	HCT116	viability after 8 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.07476760140062316	[442]	[228,293,172]	-1	hSpCas9	negative selection	1888306
43923909	43923932	22	+	26627737	HCT116	viability after 9 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-0.2491495910032071	[2178]	[531,455]	-2	hSpCas9	negative selection	1970616
43927015	43927038	22	+	26627737	HCT116	viability after 9 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.37077110389524615	[1518]	[562,493]	2	hSpCas9	negative selection	1970617
43928869	43928892	22	-	26627737	HCT116	viability after 9 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	0.951629479010913	[169]	[146,40]	6	hSpCas9	negative selection	1970618
43933073	43933096	22	-	26627737	HCT116	viability after 9 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.30903365037923525	[1738]	[595,199]	-2	hSpCas9	negative selection	1970619
43937120	43937143	22	-	26627737	HCT116	viability after 9 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	1.6524106752373444	[462]	[434,351]	8	hSpCas9	negative selection	1970620
43940104	43940127	22	+	26627737	HCT116	viability after 9 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	1.6630959490415487	[430]	[359,367]	8	hSpCas9	negative selection	1970621
43923909	43923932	22	+	26627737	HCT116	viability after 12 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.47269726488145747	[541]	[450,357,370]	4	hSpCas9	negative selection	2052931
43927015	43927038	22	+	26627737	HCT116	viability after 12 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.7624473074133253	[807]	[239,338,174]	-7	hSpCas9	negative selection	2052932
43928869	43928892	22	-	26627737	HCT116	viability after 12 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-1.3098501112880483	[197]	[20,51,54]	-8	hSpCas9	negative selection	2052933
43933073	43933096	22	-	26627737	HCT116	viability after 12 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.4344984972832168	[408]	[251,118,96]	-5	hSpCas9	negative selection	2052934
43937120	43937143	22	-	26627737	HCT116	viability after 12 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	1.029932561671731	[184]	[58,370,181]	8	hSpCas9	negative selection	2052935
43940104	43940127	22	+	26627737	HCT116	viability after 12 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.1334676577606435	[442]	[117,253,273]	-1	hSpCas9	negative selection	2052936
43923909	43923932	22	+	26627737	HCT116	viability after 15 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.3994760916190384	[541]	[379,520,327]	4	hSpCas9	negative selection	2135246
43927015	43927038	22	+	26627737	HCT116	viability after 15 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.7535461330119496	[807]	[325,239,265]	-6	hSpCas9	negative selection	2135247
43928869	43928892	22	-	26627737	HCT116	viability after 15 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-1.8520916998028725	[197]	[17,55,18]	-9	hSpCas9	negative selection	2135248
43933073	43933096	22	-	26627737	HCT116	viability after 15 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.1354448438113694	[408]	[243,171,228]	-1	hSpCas9	negative selection	2135249
43937120	43937143	22	-	26627737	HCT116	viability after 15 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	1.050227795846621	[184]	[128,301,217]	8	hSpCas9	negative selection	2135250
43940104	43940127	22	+	26627737	HCT116	viability after 15 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	0.010045370980095725	[442]	[306,148,317]	0	hSpCas9	negative selection	2135251
43923909	43923932	22	+	26627737	HCT116	viability after 18 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.43165362802196083	[541]	[136,572,334]	3	hSpCas9	negative selection	2217561
43927015	43927038	22	+	26627737	HCT116	viability after 18 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-1.1401014166080845	[807]	[109,210,209]	-7	hSpCas9	negative selection	2217562
43928869	43928892	22	-	26627737	HCT116	viability after 18 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-1.29613503104151	[197]	[44,35,35]	-8	hSpCas9	negative selection	2217563
43933073	43933096	22	-	26627737	HCT116	viability after 18 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.5945994075255048	[408]	[140,73,183]	-5	hSpCas9	negative selection	2217564
43937120	43937143	22	-	26627737	HCT116	viability after 18 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	0.07299480285119142	[184]	[77,136,62]	0	hSpCas9	negative selection	2217565
43940104	43940127	22	+	26627737	HCT116	viability after 18 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.02005850664724329	[442]	[249,97,296]	0	hSpCas9	negative selection	2217566
43947096	43947119	22	+	25494202	A375	resistance to PLX-4720 (puromycin)	CGGCTGTAATCCCAGCACTTTGG	PNPLA3	ENSG00000100344	-1.4185181893877035	[80,53]	[4,4]	-7	dCas9-VP64	positive selection	2423387
43955262	43955285	22	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGCGCGTGGACTGTGTGGGGAGG	PNPLA3	ENSG00000100344	2.0305300165586537	[3,0]	[1,2]	7	dCas9-VP64	positive selection	2445770
43955231	43955254	22	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGTGAAGGTGGGTCTGCGAGAGG	PNPLA3	ENSG00000100344	0.47987394083668333	[116,20]	[35,3]	2	dCas9-VP64	positive selection	2445771
43955207	43955230	22	-	25494202	A375	resistance to PLX-4720 (puromycin)	TCCGCTGGGAGGCTGGCGTCTGG	PNPLA3	ENSG00000100344	-1.395814437372797	[115,63]	[11,0]	-7	dCas9-VP64	positive selection	2445772
43940597	43940620	22	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCAGGAGTTTGAGACCAGCTTGG	PNPLA3	ENSG00000100344	0.362963240197711	[121,64]	[24,26]	1	dCas9-VP64	positive selection	2472639
43947096	43947119	22	+	25494202	A375	resistance to PLX-4720 (zeocin)	CGGCTGTAATCCCAGCACTTTGG	PNPLA3	ENSG00000100344	-0.5867812044469465	[72,239]	[21,43]	-6	dCas9-VP64	positive selection	2518642
43955262	43955285	22	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGCGCGTGGACTGTGTGGGGAGG	PNPLA3	ENSG00000100344	-1.2955859389349689	[448,27]	[25,36]	-9	dCas9-VP64	positive selection	2541025
43955231	43955254	22	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGTGAAGGTGGGTCTGCGAGAGG	PNPLA3	ENSG00000100344	0.028365005395953213	[36,60]	[9,21]	0	dCas9-VP64	positive selection	2541026
43955207	43955230	22	-	25494202	A375	resistance to PLX-4720 (zeocin)	TCCGCTGGGAGGCTGGCGTCTGG	PNPLA3	ENSG00000100344	0.3751206274108293	[119,62]	[19,55]	3	dCas9-VP64	positive selection	2541027
43940597	43940620	22	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCAGGAGTTTGAGACCAGCTTGG	PNPLA3	ENSG00000100344	-1.016658803330618	[35,140]	[14,11]	-8	dCas9-VP64	positive selection	2567894
43933072	43933095	22	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AACTCACCTTGAGATCCGGGGGG	PNPLA3	ENSG00000100344	-0.07985344823383766	[4,4]	[2,3]	-1	hSpCas9	positive selection	3012273
43928868	43928891	22	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CCACGCCTCTGAAGGAAGGAGGG	PNPLA3	ENSG00000100344	-0.21902938376163233	[4,4]	[3,2]	-3	hSpCas9	positive selection	3012274
43923910	43923933	22	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-0.1979127289822245	[2,2]	[2,1]	-3	hSpCas9	positive selection	3012275
43924092	43924115	22	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCGTCCCCAGACGCACCCAGCGG	PNPLA3	ENSG00000100344	-0.35058203728220827	[2,2]	[2,0]	-5	hSpCas9	positive selection	3012276
43933072	43933095	22	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AACTCACCTTGAGATCCGGGGGG	PNPLA3	ENSG00000100344	-0.4419289405821589	[4,4]	[3,0]	-6	hSpCas9	positive selection	3080131
43928868	43928891	22	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CCACGCCTCTGAAGGAAGGAGGG	PNPLA3	ENSG00000100344	0.009120803713902947	[4,4]	[3,2]	0	hSpCas9	positive selection	3080132
43923910	43923933	22	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-0.7187892799995916	[2,2]	[1,0]	-8	hSpCas9	positive selection	3080133
43924092	43924115	22	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCGTCCCCAGACGCACCCAGCGG	PNPLA3	ENSG00000100344	-0.3456804606884265	[2,2]	[2,0]	-5	hSpCas9	positive selection	3080134
43928876	43928899		-	24336571	A375	resistance to PLX after 7 days	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	-0.0024827704662128795	[12,11]	[12,11]	0	hSpCas9	positive selection	3136562
43927014	43927037		+	24336571	A375	resistance to PLX after 7 days	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.34812694587330695	[10,10]	[12,14]	8	hSpCas9	positive selection	3136563
43928825	43928848		-	24336571	A375	resistance to PLX after 7 days	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-0.3256276087211498	[7,6]	[5,5]	-8	hSpCas9	positive selection	3136564
43927148	43927171		-	24336571	A375	resistance to PLX after 7 days	TACATCCACGACTTCGTCTTTGG	PNPLA3	ENSG00000100344	-0.09263387249059707	[31,35]	[30,31]	-3	hSpCas9	positive selection	3136565
43928876	43928899		-	24336571	A375	resistance to PLX after 14 days	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	-0.09280941265360887	[18,19]	[7,7]	-1	hSpCas9	positive selection	3194355
43927014	43927037		+	24336571	A375	resistance to PLX after 14 days	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.5737619832939822	[8,15]	[9,7]	5	hSpCas9	positive selection	3194356
43928825	43928848		-	24336571	A375	resistance to PLX after 14 days	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-0.34348163753889116	[8,4]	[1,1]	-4	hSpCas9	positive selection	3194357
43927148	43927171		-	24336571	A375	resistance to PLX after 14 days	TACATCCACGACTTCGTCTTTGG	PNPLA3	ENSG00000100344	-0.893289720020004	[39,35]	[8,8]	-9	hSpCas9	positive selection	3194358
43928876	43928899		-	24336571	A375	viability after 7 days	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	-0.0598827660763701	[13]	[12,11]	-1	hSpCas9	negative selection	3252148
43927014	43927037		+	24336571	A375	viability after 7 days	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.1347203473530002	[10]	[10,10]	2	hSpCas9	negative selection	3252149
43928825	43928848		-	24336571	A375	viability after 7 days	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-0.1693440346812657	[8]	[7,6]	-2	hSpCas9	negative selection	3252150
43927148	43927171		-	24336571	A375	viability after 7 days	TACATCCACGACTTCGTCTTTGG	PNPLA3	ENSG00000100344	0.43591139091560127	[25]	[31,35]	6	hSpCas9	negative selection	3252151
43928876	43928899		-	24336571	A375	viability after 14 days	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.5386923916650901	[13]	[18,19]	7	hSpCas9	negative selection	3309941
43927014	43927037		+	24336571	A375	viability after 14 days	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.36257338754454993	[10]	[8,15]	4	hSpCas9	negative selection	3309942
43928825	43928848		-	24336571	A375	viability after 14 days	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-0.2785080539553372	[8]	[8,4]	-3	hSpCas9	negative selection	3309943
43927148	43927171		-	24336571	A375	viability after 14 days	TACATCCACGACTTCGTCTTTGG	PNPLA3	ENSG00000100344	0.6200074576949367	[25]	[39,35]	7	hSpCas9	negative selection	3309944
43933051	43933074	22	-	27383988	293T	resistance to West Nile virus (flavivirus)	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	2.0478728458168853	[73,73]	[1,1]	7	hSpCas9	positive selection	3386566
43927014	43927037	22	+	27383988	293T	resistance to West Nile virus (flavivirus)	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	1.5216493132482016	[372,372]	[6,6]	6	hSpCas9	positive selection	3386567
43932948	43932971	22	-	27383988	293T	resistance to West Nile virus (flavivirus)	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.26864152467366925	[126,126]	[0,0]	1	hSpCas9	positive selection	3386568
43933072	43933095	22	-	26780180	HT29	viability (Avana library 4 designs)	AACTCACCTTGAGATCCGGGGGG	PNPLA3	ENSG00000100344	1.25194660506792	[]	[]	5	hSpCas9	negative selection	3450382
43928868	43928891	22	-	26780180	HT29	viability (Avana library 4 designs)	CCACGCCTCTGAAGGAAGGAGGG	PNPLA3	ENSG00000100344	0.585048856554102	[]	[]	2	hSpCas9	negative selection	3450383
43923909	43923932	22	+	26780180	HT29	viability (Avana library 4 designs)	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	1.69959407390757	[]	[]	6	hSpCas9	negative selection	3450384
43924092	43924115	22	-	26780180	HT29	viability (Avana library 4 designs)	GCGTCCCCAGACGCACCCAGCGG	PNPLA3	ENSG00000100344	0.510425161853253	[]	[]	2	hSpCas9	negative selection	3450385
43923909	43923932	22	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	6.23915401713091	[]	[]	9	hSpCas9	negative selection	3545597
43933072	43933095	22	-	26780180	A375	viability (Avana lentiCRISPRv2)	AACTCACCTTGAGATCCGGGGGG	PNPLA3	ENSG00000100344	2.40725183930281	[]	[]	3	hSpCas9	negative selection	3545598
43924092	43924115	22	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCGTCCCCAGACGCACCCAGCGG	PNPLA3	ENSG00000100344	5.90734297703243	[]	[]	9	hSpCas9	negative selection	3545599
43928868	43928891	22	-	26780180	A375	viability (Avana lentiCRISPRv2)	CCACGCCTCTGAAGGAAGGAGGG	PNPLA3	ENSG00000100344	2.72431685999422	[]	[]	4	hSpCas9	negative selection	3545600
43926951	43926974	22	-	26780180	A375	viability (Avana lentiCRISPRv2)	CCTTCCGCACAAGATCTGAGAGG	PNPLA3	ENSG00000100344	2.51167964152303	[]	[]	4	hSpCas9	negative selection	3545601
43927026	43927049	22	-	26780180	A375	viability (Avana lentiCRISPRv2)	ATTTGCAGAGACCCTGTCGGAGG	PNPLA3	ENSG00000100344	4.96400568382934	[]	[]	8	hSpCas9	negative selection	3545602
43923909	43923932	22	+	26780180	A375	viability (Avana lentiGuide)	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	1.69793167968128	[]	[]	2	hSpCas9	negative selection	3654256
43933072	43933095	22	-	26780180	A375	viability (Avana lentiGuide)	AACTCACCTTGAGATCCGGGGGG	PNPLA3	ENSG00000100344	1.93354642024169	[]	[]	2	hSpCas9	negative selection	3654257
43924092	43924115	22	-	26780180	A375	viability (Avana lentiGuide)	GCGTCCCCAGACGCACCCAGCGG	PNPLA3	ENSG00000100344	-2.43987979215368	[]	[]	-4	hSpCas9	negative selection	3654258
43928868	43928891	22	-	26780180	A375	viability (Avana lentiGuide)	CCACGCCTCTGAAGGAAGGAGGG	PNPLA3	ENSG00000100344	1.52203980522146	[]	[]	1	hSpCas9	negative selection	3654259
43926951	43926974	22	-	26780180	A375	viability (Avana lentiGuide)	CCTTCCGCACAAGATCTGAGAGG	PNPLA3	ENSG00000100344	-3.38720479521824	[]	[]	-6	hSpCas9	negative selection	3654260
43927026	43927049	22	-	26780180	A375	viability (Avana lentiGuide)	ATTTGCAGAGACCCTGTCGGAGG	PNPLA3	ENSG00000100344	-0.0322086938927123	[]	[]	0	hSpCas9	negative selection	3654261
43923909	43923932	22	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.47008015525767866	[4]	[6,5]	9	hSpCas9	positive selection	3762915
43933072	43933095	22	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AACTCACCTTGAGATCCGGGGGG	PNPLA3	ENSG00000100344	-0.05624754828898715	[6]	[6,5]	-1	hSpCas9	positive selection	3762916
43924092	43924115	22	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCGTCCCCAGACGCACCCAGCGG	PNPLA3	ENSG00000100344	-0.027408036444149242	[3]	[5,1]	0	hSpCas9	positive selection	3762917
43928868	43928891	22	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCACGCCTCTGAAGGAAGGAGGG	PNPLA3	ENSG00000100344	0.23174871972527364	[5]	[6,5]	6	hSpCas9	positive selection	3762918
43926951	43926974	22	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCTTCCGCACAAGATCTGAGAGG	PNPLA3	ENSG00000100344	0.18469179745538727	[5]	[6,5]	5	hSpCas9	positive selection	3762919
43927026	43927049	22	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATTTGCAGAGACCCTGTCGGAGG	PNPLA3	ENSG00000100344	0.2718515617183002	[5]	[5,6]	7	hSpCas9	positive selection	3762920
43923909	43923932	22	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.1840329307884136	[4]	[5,3]	4	hSpCas9	positive selection	3871522
43933072	43933095	22	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AACTCACCTTGAGATCCGGGGGG	PNPLA3	ENSG00000100344	-0.4030217923842565	[6]	[4,2]	-5	hSpCas9	positive selection	3871523
43924092	43924115	22	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCGTCCCCAGACGCACCCAGCGG	PNPLA3	ENSG00000100344	-0.87016017973225	[4]	[0,2]	-8	hSpCas9	positive selection	3871524
43928868	43928891	22	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCACGCCTCTGAAGGAAGGAGGG	PNPLA3	ENSG00000100344	0.3331764956155418	[5]	[5,5]	8	hSpCas9	positive selection	3871525
43926951	43926974	22	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCTTCCGCACAAGATCTGAGAGG	PNPLA3	ENSG00000100344	0.18432945862421227	[6]	[5,6]	4	hSpCas9	positive selection	3871526
43927026	43927049	22	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATTTGCAGAGACCCTGTCGGAGG	PNPLA3	ENSG00000100344	0.04280755770248694	[5]	[3,4]	0	hSpCas9	positive selection	3871527
43928876	43928899	22	-	26780180	A375	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	1.07533790280281	[]	[]	5	hSpCas9	negative selection	3982355
43927014	43927037	22	+	26780180	A375	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.367365671486668	[]	[]	0	hSpCas9	negative selection	3982356
43928825	43928848	22	-	26780180	A375	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.927591457296682	[]	[]	4	hSpCas9	negative selection	3982357
43926974	43926997	22	-	26780180	A375	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	1.15427589148735	[]	[]	6	hSpCas9	negative selection	3982358
43932948	43932971	22	-	26780180	A375	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	1.05691007628377	[]	[]	5	hSpCas9	negative selection	3982359
43933051	43933074	22	-	26780180	A375	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	1.11703032369639	[]	[]	5	hSpCas9	negative selection	3982360
43928876	43928899	22	-	26780180	HT29	viability (GeCKOv2 library)	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	1.78379425442939	[]	[]	8	hSpCas9	negative selection	4090321
43927014	43927037	22	+	26780180	HT29	viability (GeCKOv2 library)	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.318567623148882	[]	[]	0	hSpCas9	negative selection	4090322
43928825	43928848	22	-	26780180	HT29	viability (GeCKOv2 library)	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.618487081383325	[]	[]	2	hSpCas9	negative selection	4090323
43926974	43926997	22	-	26780180	HT29	viability (GeCKOv2 library)	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	1.39017221010842	[]	[]	7	hSpCas9	negative selection	4090324
43932948	43932971	22	-	26780180	HT29	viability (GeCKOv2 library)	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	1.02162538906031	[]	[]	4	hSpCas9	negative selection	4090325
43933051	43933074	22	-	26780180	HT29	viability (GeCKOv2 library)	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	1.32588260827235	[]	[]	6	hSpCas9	negative selection	4090326
43928876	43928899	22	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.02613868791786913	[3]	[1,2]	0	hSpCas9	positive selection	4161597
43927014	43927037	22	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.5447588774097667	[3]	[3,3]	9	hSpCas9	positive selection	4161598
43928825	43928848	22	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-0.5829131226804869	[2]	[0,0]	-9	hSpCas9	positive selection	4161599
43927148	43927171	22	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TACATCCACGACTTCGTCTTTGG	PNPLA3	ENSG00000100344	0.08984916849369906	[4]	[3,3]	2	hSpCas9	positive selection	4161600
43928876	43928899	22	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	-0.11066555520740719	[3]	[0,0,4,0]	-1	hSpCas9	positive selection	4225619
43927014	43927037	22	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	-0.3846714643465458	[3]	[0,0,1,0]	-5	hSpCas9	positive selection	4225620
43928825	43928848	22	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-0.4487967433635316	[3]	[1,0,0,0]	-6	hSpCas9	positive selection	4225621
43927148	43927171	22	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TACATCCACGACTTCGTCTTTGG	PNPLA3	ENSG00000100344	0.26921511714158586	[3]	[4,3,0,0]	2	hSpCas9	positive selection	4225622
43926974	43926997	22	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.47263396021579057	[2]	[3,2]	8	hSpCas9	positive selection	4291060
43928825	43928848	22	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.36656739451520337	[3]	[3,2]	7	hSpCas9	positive selection	4291061
43928876	43928899	22	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	-0.0338340967864036	[2]	[2,1]	0	hSpCas9	positive selection	4291062
43933051	43933074	22	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.0869489322265844	[1]	[1,0]	-2	hSpCas9	positive selection	4355309
43927014	43927037	22	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.1952544803004339	[3]	[4,2]	4	hSpCas9	positive selection	4355310
43932948	43932971	22	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.17208193457642298	[2]	[2,1]	3	hSpCas9	positive selection	4355311
43924037	43924059	22	+	27760321	OCIAML3	viability	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	-0.1477528672343152	[671,633]	[384,560]	-1	hSpCas9	negative selection	4429014
43924084	43924106	22	-	27760321	OCIAML3	viability	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	-0.011005969315512426	[496,364]	[343,314]	0	hSpCas9	negative selection	4429015
43927016	43927038	22	+	27760321	OCIAML3	viability	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.14648966722812293	[605,510]	[357,438]	-1	hSpCas9	negative selection	4429016
43927144	43927166	22	+	27760321	OCIAML3	viability	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	0.21627498252184885	[246,228]	[227,200]	2	hSpCas9	negative selection	4429017
43932946	43932968	22	-	27760321	OCIAML3	viability	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	-0.5018888601815199	[206,148]	[49,158]	-5	hSpCas9	negative selection	4429018
43924037	43924059	22	+	27760321	OCIAML2	viability	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	0.6218763778208526	[671,633]	[719,936]	8	hSpCas9	negative selection	4512477
43924084	43924106	22	-	27760321	OCIAML2	viability	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	0.10215787501564616	[496,364]	[299,463]	1	hSpCas9	negative selection	4512478
43927016	43927038	22	+	27760321	OCIAML2	viability	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.08391936267868905	[605,510]	[379,604]	1	hSpCas9	negative selection	4512479
43927144	43927166	22	+	27760321	OCIAML2	viability	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	0.9715779317576471	[246,228]	[286,496]	9	hSpCas9	negative selection	4512480
43932946	43932968	22	-	27760321	OCIAML2	viability	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	0.17488732909695792	[206,148]	[131,198]	2	hSpCas9	negative selection	4512481
43924037	43924059	22	+	27760321	MV411	viability	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	-0.21266025654917586	[671,633]	[358,391]	-1	hSpCas9	negative selection	4595940
43924084	43924106	22	-	27760321	MV411	viability	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	0.5226040815046221	[496,364]	[385,432]	4	hSpCas9	negative selection	4595941
43927016	43927038	22	+	27760321	MV411	viability	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	1.4874709596168185	[605,510]	[1264,675]	9	hSpCas9	negative selection	4595942
43927144	43927166	22	+	27760321	MV411	viability	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	-1.331318897512222	[246,228]	[93,14]	-7	hSpCas9	negative selection	4595943
43932946	43932968	22	-	27760321	MV411	viability	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	-0.6648316315831115	[206,148]	[4,175]	-4	hSpCas9	negative selection	4595944
43924037	43924059	22	+	27760321	HL60	viability	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	0.1674605103199508	[671,633]	[652,542]	2	hSpCas9	negative selection	4679403
43924084	43924106	22	-	27760321	HL60	viability	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	-0.5121286781389128	[496,364]	[213,276]	-5	hSpCas9	negative selection	4679404
43927016	43927038	22	+	27760321	HL60	viability	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.6773240379446122	[605,510]	[291,275]	-6	hSpCas9	negative selection	4679405
43927144	43927166	22	+	27760321	HL60	viability	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	-0.17861938692726653	[246,228]	[181,160]	-2	hSpCas9	negative selection	4679406
43932946	43932968	22	-	27760321	HL60	viability	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	0.4157306330372449	[206,148]	[241,138]	5	hSpCas9	negative selection	4679407
43924037	43924059	22	+	27760321	HT1080	viability	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	1.7779840343419249	[633,494]	[986,534]	8	hSpCas9	negative selection	4762866
43924084	43924106	22	-	27760321	HT1080	viability	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	0.18489543907836536	[364,284]	[171,119]	0	hSpCas9	negative selection	4762867
43927016	43927038	22	+	27760321	HT1080	viability	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.045673398102131224	[510,398]	[167,207]	0	hSpCas9	negative selection	4762868
43927144	43927166	22	+	27760321	HT1080	viability	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	0.8273426899909396	[228,178]	[74,219]	4	hSpCas9	negative selection	4762869
43932946	43932968	22	-	27760321	HT1080	viability	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	-4.181083806619888	[148,115]	[0,4]	-8	hSpCas9	negative selection	4762870
43924037	43924059	22	+	27760321	HT29	viability after 7 days	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	-0.15169751044798746	[633,494]	[872,576,543]	-2	hSpCas9	negative selection	4846329
43924084	43924106	22	-	27760321	HT29	viability after 7 days	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	0.08728135227701164	[364,284]	[597,402,354]	1	hSpCas9	negative selection	4846330
43927016	43927038	22	+	27760321	HT29	viability after 7 days	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.13927804204329797	[510,398]	[1051,575,370]	2	hSpCas9	negative selection	4846331
43927144	43927166	22	+	27760321	HT29	viability after 7 days	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	-0.08326033695797364	[228,178]	[244,278,218]	-1	hSpCas9	negative selection	4846332
43932946	43932968	22	-	27760321	HT29	viability after 7 days	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	0.6941658328229912	[148,115]	[217,446,156]	9	hSpCas9	negative selection	4846333
43924037	43924059	22	+	27760321	HT29	viability after 25 days	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	-0.4278955474569658	[633,494]	[441,443,562]	-4	hSpCas9	negative selection	4929792
43924084	43924106	22	-	27760321	HT29	viability after 25 days	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	0.32501039945423704	[364,284]	[259,622,531]	3	hSpCas9	negative selection	4929793
43927016	43927038	22	+	27760321	HT29	viability after 25 days	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.2396151850096378	[510,398]	[526,639,686]	2	hSpCas9	negative selection	4929794
43927144	43927166	22	+	27760321	HT29	viability after 25 days	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	-0.32931525399928097	[228,178]	[88,257,218]	-3	hSpCas9	negative selection	4929795
43932946	43932968	22	-	27760321	HT29	viability after 25 days	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	0.41386306021115304	[148,115]	[200,174,231]	4	hSpCas9	negative selection	4929796
43924037	43924059	22	+	27760321	HT29	viability after 22 days	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	-0.27485196849812593	[633,494]	[485,554,578]	-3	hSpCas9	negative selection	5013255
43924084	43924106	22	-	27760321	HT29	viability after 22 days	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	0.36229333471073355	[364,284]	[327,654,469]	4	hSpCas9	negative selection	5013256
43927016	43927038	22	+	27760321	HT29	viability after 22 days	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.16648586583138697	[510,398]	[624,462,682]	1	hSpCas9	negative selection	5013257
43927144	43927166	22	+	27760321	HT29	viability after 22 days	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	0.16224336640692072	[228,178]	[240,328,221]	1	hSpCas9	negative selection	5013258
43932946	43932968	22	-	27760321	HT29	viability after 22 days	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	0.3076128835929397	[148,115]	[194,235,136]	3	hSpCas9	negative selection	5013259
43924037	43924059	22	+	27760321	HT29	viability after 19 days	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	-0.42339199672529854	[633,494]	[811,411,262]	-4	hSpCas9	negative selection	5096718
43924084	43924106	22	-	27760321	HT29	viability after 19 days	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	0.2923557723142192	[364,284]	[318,521,507]	2	hSpCas9	negative selection	5096719
43927016	43927038	22	+	27760321	HT29	viability after 19 days	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.15671940183896127	[510,398]	[641,537,246]	-1	hSpCas9	negative selection	5096720
43927144	43927166	22	+	27760321	HT29	viability after 19 days	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	-0.06996247682474677	[228,178]	[217,218,228]	0	hSpCas9	negative selection	5096721
43932946	43932968	22	-	27760321	HT29	viability after 19 days	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	0.6607976484209117	[148,115]	[214,210,287]	6	hSpCas9	negative selection	5096722
43924037	43924059	22	+	27760321	HT29	viability after 16 days	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	-0.37719321669218553	[633,494]	[453,512,487]	-4	hSpCas9	negative selection	5180181
43924084	43924106	22	-	27760321	HT29	viability after 16 days	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	0.39821806324847414	[364,284]	[511,618,305]	4	hSpCas9	negative selection	5180182
43927016	43927038	22	+	27760321	HT29	viability after 16 days	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.2152677842572625	[510,398]	[802,548,441]	2	hSpCas9	negative selection	5180183
43927144	43927166	22	+	27760321	HT29	viability after 16 days	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	-0.04959019720420421	[228,178]	[238,271,150]	0	hSpCas9	negative selection	5180184
43932946	43932968	22	-	27760321	HT29	viability after 16 days	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	-0.24163801824654518	[148,115]	[158,57,163]	-3	hSpCas9	negative selection	5180185
43924037	43924059	22	+	27760321	HT29	viability after 13 days	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	-0.44491225185537997	[633,494]	[496,495,451]	-5	hSpCas9	negative selection	5263644
43924084	43924106	22	-	27760321	HT29	viability after 13 days	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	0.3303816568041935	[364,284]	[325,562,529]	4	hSpCas9	negative selection	5263645
43927016	43927038	22	+	27760321	HT29	viability after 13 days	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.5652902622300657	[510,398]	[728,863,751]	7	hSpCas9	negative selection	5263646
43927144	43927166	22	+	27760321	HT29	viability after 13 days	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	-0.18156377769522403	[228,178]	[143,218,259]	-2	hSpCas9	negative selection	5263647
43932946	43932968	22	-	27760321	HT29	viability after 13 days	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	0.9685579212167323	[148,115]	[409,157,331]	9	hSpCas9	negative selection	5263648
43924037	43924059	22	+	27760321	HT29	viability after 10 days	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	-0.553296516174892	[633,494]	[473,465,499]	-6	hSpCas9	negative selection	5347107
43924084	43924106	22	-	27760321	HT29	viability after 10 days	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	0.2883287202706341	[364,284]	[579,625,288]	4	hSpCas9	negative selection	5347108
43927016	43927038	22	+	27760321	HT29	viability after 10 days	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.0500093070353822	[510,398]	[765,641,362]	0	hSpCas9	negative selection	5347109
43927144	43927166	22	+	27760321	HT29	viability after 10 days	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	0.46076651699587673	[228,178]	[262,255,525]	6	hSpCas9	negative selection	5347110
43932946	43932968	22	-	27760321	HT29	viability after 10 days	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	0.6324715913736043	[148,115]	[298,192,274]	8	hSpCas9	negative selection	5347111
43924037	43924059	22	+	27760321	MOLM13	viability	GTTGTTCGGCGCTTCGGCCGGG	PNPLA3	ENSG00000100344	0.6082506172816232	[671,633]	[546,574]	4	hSpCas9	negative selection	5430570
43924084	43924106	22	-	27760321	MOLM13	viability	GACGCACCCAGCGGGATACCGG	PNPLA3	ENSG00000100344	0.4992555464414396	[496,364]	[198,460]	3	hSpCas9	negative selection	5430571
43927016	43927038	22	+	27760321	MOLM13	viability	TAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.14550109090507918	[605,510]	[511,206]	1	hSpCas9	negative selection	5430572
43927144	43927166	22	+	27760321	MOLM13	viability	CGGTCCAAAGACGAAGTCGTGG	PNPLA3	ENSG00000100344	1.875955041180791	[246,228]	[997,62]	9	hSpCas9	negative selection	5430573
43932946	43932968	22	-	27760321	MOLM13	viability	GTCGTACTCCCCATAGAAGGGG	PNPLA3	ENSG00000100344	0.04721793580795097	[206,148]	[166,47]	0	hSpCas9	negative selection	5430574
43923798	43923821	22	+	27661255	K562	viability	GCAGGGTAGAGAGCGCTTGCGGG	PNPLA3	ENSG00000100344	0.15979910239127748	[253,293]	[265,224]	5	dCas9-KRAB	negative selection	5502903
43924195	43924218	22	+	27661255	K562	viability	GCGGGCATCGGACGCGGACACGG	PNPLA3	ENSG00000100344	-0.012239714495528131	[987,866]	[778,699]	0	dCas9-KRAB	negative selection	5502904
43923974	43923997	22	-	27661255	K562	viability	GGCAGCGGGTCGCCCCGACGTGG	PNPLA3	ENSG00000100344	0.032071493754970426	[959,869]	[820,686]	1	dCas9-KRAB	negative selection	5502905
43924185	43924208	22	-	27661255	K562	viability	GTCCGATGCCCGCTCCTCCAGGG	PNPLA3	ENSG00000100344	0.15526057631417772	[694,784]	[719,602]	5	dCas9-KRAB	negative selection	5502906
43926974	43926997	22	-	27260156	BXPC3	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.27707068527534884	[386]	[344,536,442,666]	6	hSpCas9	negative selection	5563520
43928825	43928848	22	-	27260156	BXPC3	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.10741361891831636	[534]	[463,676,659,618]	2	hSpCas9	negative selection	5563521
43928876	43928899	22	-	27260156	BXPC3	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.12874325170885742	[398]	[417,397,539,476]	3	hSpCas9	negative selection	5563522
43933051	43933074	22	-	27260156	BXPC3	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.35960267791232914	[122]	[113,72,84,131]	-7	hSpCas9	negative selection	5627769
43927014	43927037	22	+	27260156	BXPC3	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.17693540233822302	[862]	[937,916,1114,1133]	4	hSpCas9	negative selection	5627770
43932948	43932971	22	-	27260156	BXPC3	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.17715567584916148	[318]	[274,243,258,419]	-4	hSpCas9	negative selection	5627771
43926974	43926997	22	-	27260156	A673	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.44098166787636217	[386]	[623,586,678,631]	8	hSpCas9	negative selection	5684771
43928825	43928848	22	-	27260156	A673	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.1840990395318039	[534]	[860,577,761,735]	4	hSpCas9	negative selection	5684772
43928876	43928899	22	-	27260156	A673	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.19328584688860997	[398]	[565,592,418,617]	4	hSpCas9	negative selection	5684773
43933051	43933074	22	-	27260156	A673	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.015718978033582687	[122]	[197,106,141,143]	0	hSpCas9	negative selection	5749020
43927014	43927037	22	+	27260156	A673	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.18195488154987993	[862]	[1220,1139,1124,1222]	4	hSpCas9	negative selection	5749021
43932948	43932971	22	-	27260156	A673	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.02364094723720578	[318]	[349,302,441,462]	0	hSpCas9	negative selection	5749022
43926974	43926997	22	-	27260156	A375	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.6365604065869206	[386]	[665,1019,620,561]	8	hSpCas9	negative selection	5806022
43928825	43928848	22	-	27260156	A375	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.3891286849716548	[534]	[713,1303,833,520]	5	hSpCas9	negative selection	5806023
43928876	43928899	22	-	27260156	A375	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	-0.05154588086174697	[398]	[389,530,438,447]	0	hSpCas9	negative selection	5806024
43933051	43933074	22	-	27260156	A375	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.9023908862069625	[122]	[115,6,118,57]	-8	hSpCas9	negative selection	5870271
43927014	43927037	22	+	27260156	A375	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.06601356998037233	[862]	[1495,1091,822,839]	0	hSpCas9	negative selection	5870272
43932948	43932971	22	-	27260156	A375	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.0653149322488456	[318]	[299,604,475,225]	0	hSpCas9	negative selection	5870273
43926974	43926997	22	-	27260156	COLO741	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.5149172645684925	[386]	[704,706,705]	8	hSpCas9	negative selection	5927273
43928825	43928848	22	-	27260156	COLO741	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.07703643480436617	[534]	[796,804,576]	1	hSpCas9	negative selection	5927274
43928876	43928899	22	-	27260156	COLO741	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.04326789265360648	[398]	[650,447,488]	0	hSpCas9	negative selection	5927275
43933051	43933074	22	-	27260156	COLO741	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.16522048890039365	[122]	[217,168,146]	3	hSpCas9	negative selection	5991522
43927014	43927037	22	+	27260156	COLO741	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.1238672624404833	[862]	[1146,1257,1192]	2	hSpCas9	negative selection	5991523
43932948	43932971	22	-	27260156	COLO741	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.06636464839397871	[318]	[483,357,440]	1	hSpCas9	negative selection	5991524
43926974	43926997	22	-	27260156	CAL120	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.930863717549944	[386]	[790,1038,904]	9	hSpCas9	negative selection	6048524
43928825	43928848	22	-	27260156	CAL120	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.07571877667529997	[534]	[591,789,705]	1	hSpCas9	negative selection	6048525
43928876	43928899	22	-	27260156	CAL120	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.14288353316617886	[398]	[687,517,460]	2	hSpCas9	negative selection	6048526
43933051	43933074	22	-	27260156	CAL120	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.023779528536069572	[122]	[90,208,156]	0	hSpCas9	negative selection	6112773
43927014	43927037	22	+	27260156	CAL120	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.3248155530819099	[862]	[1420,995,1623]	5	hSpCas9	negative selection	6112774
43932948	43932971	22	-	27260156	CAL120	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.3758602790361627	[318]	[354,207,360]	-5	hSpCas9	negative selection	6112775
43926974	43926997	22	-	27260156	CADOES1	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.7685222797340552	[386]	[648,631,623,544]	9	hSpCas9	negative selection	6169775
43928825	43928848	22	-	27260156	CADOES1	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.13297211604541104	[534]	[486,635,509,549]	2	hSpCas9	negative selection	6169776
43928876	43928899	22	-	27260156	CADOES1	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	-0.005623502862087015	[398]	[522,325,364,259]	0	hSpCas9	negative selection	6169777
43933051	43933074	22	-	27260156	CADOES1	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.2911461021307562	[122]	[101,100,101,67]	-5	hSpCas9	negative selection	6234024
43927014	43927037	22	+	27260156	CADOES1	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.13689830131022696	[862]	[992,744,795,999]	2	hSpCas9	negative selection	6234025
43932948	43932971	22	-	27260156	CADOES1	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.15658240916359878	[318]	[260,280,198,325]	-3	hSpCas9	negative selection	6234026
43926974	43926997	22	-	27260156	EWS502	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.6263306852146657	[386]	[417,558,871,717]	9	hSpCas9	negative selection	6291026
43928825	43928848	22	-	27260156	EWS502	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.14950332068098482	[534]	[485,612,660,780]	2	hSpCas9	negative selection	6291027
43928876	43928899	22	-	27260156	EWS502	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.13375180722544255	[398]	[428,423,603,398]	2	hSpCas9	negative selection	6291028
43933051	43933074	22	-	27260156	EWS502	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.1833152222556511	[122]	[114,147,146,187]	3	hSpCas9	negative selection	6355275
43927014	43927037	22	+	27260156	EWS502	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.24091033898974223	[862]	[1069,1018,915,1330]	4	hSpCas9	negative selection	6355276
43932948	43932971	22	-	27260156	EWS502	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.2336682920112833	[318]	[332,553,410,282]	4	hSpCas9	negative selection	6355277
43926974	43926997	22	-	27260156	EW8	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.2848774390276879	[386]	[286,417,344,472]	5	hSpCas9	negative selection	6412277
43928825	43928848	22	-	27260156	EW8	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.11804295265116094	[534]	[531,451,425,484]	2	hSpCas9	negative selection	6412278
43928876	43928899	22	-	27260156	EW8	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.12329254649642514	[398]	[402,279,273,468]	2	hSpCas9	negative selection	6412279
43933051	43933074	22	-	27260156	EW8	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.46082701239001667	[122]	[188,103,118,144]	8	hSpCas9	negative selection	6476526
43927014	43927037	22	+	27260156	EW8	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.22206677188008683	[862]	[1063,684,765,780]	4	hSpCas9	negative selection	6476527
43932948	43932971	22	-	27260156	EW8	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.246958309555539	[318]	[364,107,184,233]	-5	hSpCas9	negative selection	6476528
43926974	43926997	22	-	27260156	CORL105	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.5319564976954856	[386]	[615,757,617,618]	8	hSpCas9	negative selection	6533528
43928825	43928848	22	-	27260156	CORL105	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.39355466522903976	[534]	[922,696,975,724]	7	hSpCas9	negative selection	6533529
43928876	43928899	22	-	27260156	CORL105	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.47207299149161625	[398]	[611,548,762,685]	8	hSpCas9	negative selection	6533530
43933051	43933074	22	-	27260156	CORL105	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.575248755894348	[122]	[258,213,196,186]	9	hSpCas9	negative selection	6597777
43927014	43927037	22	+	27260156	CORL105	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.29006579271432287	[862]	[1232,1111,1606,1049]	5	hSpCas9	negative selection	6597778
43932948	43932971	22	-	27260156	CORL105	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.33176530558146	[318]	[275,299,296,312]	-6	hSpCas9	negative selection	6597779
43926974	43926997	22	-	27260156	HS294T	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.5642491011457693	[386]	[187,282,204,206]	7	hSpCas9	negative selection	6654779
43928825	43928848	22	-	27260156	HS294T	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-0.10233323438510392	[534]	[161,129,196,304]	-1	hSpCas9	negative selection	6654780
43928876	43928899	22	-	27260156	HS294T	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	1.1310700605277244	[398]	[273,347,422,305]	9	hSpCas9	negative selection	6654781
43933051	43933074	22	-	27260156	HS294T	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.5940366076461796	[122]	[27,26,36,34]	-7	hSpCas9	negative selection	6719028
43927014	43927037	22	+	27260156	HS294T	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.146739248523847	[862]	[326,449,304,400]	2	hSpCas9	negative selection	6719029
43932948	43932971	22	-	27260156	HS294T	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.18230181598126294	[318]	[185,77,82,223]	2	hSpCas9	negative selection	6719030
43926974	43926997	22	-	27260156	HCC44	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.645929706877138	[386]	[854,459,988,534]	9	hSpCas9	negative selection	6776030
43928825	43928848	22	-	27260156	HCC44	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.09955098730016981	[534]	[783,710,563,521]	1	hSpCas9	negative selection	6776031
43928876	43928899	22	-	27260156	HCC44	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.3344182747830425	[398]	[1083,342,445,459]	5	hSpCas9	negative selection	6776032
43933051	43933074	22	-	27260156	HCC44	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.47660270235901714	[122]	[152,149,376,128]	7	hSpCas9	negative selection	6840279
43927014	43927037	22	+	27260156	HCC44	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.29906128687571876	[862]	[1526,776,1390,1220]	5	hSpCas9	negative selection	6840280
43932948	43932971	22	-	27260156	HCC44	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.22487863534738373	[318]	[195,343,443,257]	-4	hSpCas9	negative selection	6840281
43926974	43926997	22	-	27260156	G402	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.7913697711572169	[386]	[1771,681,337,613]	8	hSpCas9	negative selection	6897281
43928825	43928848	22	-	27260156	G402	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.05449785613468308	[534]	[858,518,838,516]	0	hSpCas9	negative selection	6897282
43928876	43928899	22	-	27260156	G402	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.40682701992584	[398]	[464,455,1181,448]	5	hSpCas9	negative selection	6897283
43933051	43933074	22	-	27260156	G402	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-1.0238386640654968	[122]	[46,91,54,96]	-8	hSpCas9	negative selection	6961530
43927014	43927037	22	+	27260156	G402	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.5381552052198462	[862]	[1432,1370,1510,1760]	6	hSpCas9	negative selection	6961531
43932948	43932971	22	-	27260156	G402	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.9069211208097844	[318]	[164,238,250,171]	-8	hSpCas9	negative selection	6961532
43926974	43926997	22	-	27260156	L33	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.47461912052131633	[386]	[569,181,310,639]	8	hSpCas9	negative selection	7018532
43928825	43928848	22	-	27260156	L33	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.07032594869204456	[534]	[541,239,352,557]	1	hSpCas9	negative selection	7018533
43928876	43928899	22	-	27260156	L33	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.40841765648662737	[398]	[563,165,384,535]	8	hSpCas9	negative selection	7018534
43933051	43933074	22	-	27260156	L33	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.009738342426197866	[122]	[97,46,109,101]	0	hSpCas9	negative selection	7082781
43927014	43927037	22	+	27260156	L33	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.0365112869255394	[862]	[925,298,671,815]	0	hSpCas9	negative selection	7082782
43932948	43932971	22	-	27260156	L33	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.24176334306435704	[318]	[425,122,229,414]	5	hSpCas9	negative selection	7082783
43926974	43926997	22	-	27260156	K562	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.829044219118001	[386]	[876,949,289,386]	9	hSpCas9	negative selection	7139783
43928825	43928848	22	-	27260156	K562	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.5799953420862345	[534]	[915,760,530,653]	7	hSpCas9	negative selection	7139784
43928876	43928899	22	-	27260156	K562	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.25993899034907864	[398]	[272,283,877,258]	3	hSpCas9	negative selection	7139785
43933051	43933074	22	-	27260156	K562	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.5196595043637142	[122]	[284,246,78,42]	6	hSpCas9	negative selection	7204032
43927014	43927037	22	+	27260156	K562	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.14483654759008835	[862]	[778,803,1157,656]	1	hSpCas9	negative selection	7204033
43932948	43932971	22	-	27260156	K562	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.013704855510595748	[318]	[383,355,103,287]	0	hSpCas9	negative selection	7204034
43926974	43926997	22	-	27260156	HT29	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.6147533652386721	[386]	[884,876,649,515]	9	hSpCas9	negative selection	7261034
43928825	43928848	22	-	27260156	HT29	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.2766039442415064	[534]	[873,838,839,623]	5	hSpCas9	negative selection	7261035
43928876	43928899	22	-	27260156	HT29	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.1986975810687661	[398]	[502,653,595,482]	4	hSpCas9	negative selection	7261036
43933051	43933074	22	-	27260156	HT29	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.5173796373495672	[122]	[255,228,132,237]	8	hSpCas9	negative selection	7325283
43927014	43927037	22	+	27260156	HT29	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.13215982663144565	[862]	[1257,1102,1139,1099]	2	hSpCas9	negative selection	7325284
43932948	43932971	22	-	27260156	HT29	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.25832032707015107	[318]	[259,279,387,353]	-5	hSpCas9	negative selection	7325285
43926974	43926997	22	-	27260156	MHHES1	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.29661807673331414	[386]	[728,530,442,464]	5	hSpCas9	negative selection	7382285
43928825	43928848	22	-	27260156	MHHES1	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.16603715924633877	[534]	[857,748,573,562]	3	hSpCas9	negative selection	7382286
43928876	43928899	22	-	27260156	MHHES1	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	-0.008435992839196632	[398]	[653,310,580,281]	0	hSpCas9	negative selection	7382287
43933051	43933074	22	-	27260156	MHHES1	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.36950928449974385	[122]	[315,151,108,153]	6	hSpCas9	negative selection	7446534
43927014	43927037	22	+	27260156	MHHES1	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.0848943217989867	[862]	[1106,1173,1195,720]	1	hSpCas9	negative selection	7446535
43932948	43932971	22	-	27260156	MHHES1	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.6688726039343759	[318]	[270,210,232,194]	-8	hSpCas9	negative selection	7446536
43926974	43926997	22	-	27260156	MEWO	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.49213366538087755	[386]	[506,549,469]	8	hSpCas9	negative selection	7503536
43928825	43928848	22	-	27260156	MEWO	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.22635810836350267	[534]	[568,446,737]	5	hSpCas9	negative selection	7503537
43928876	43928899	22	-	27260156	MEWO	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.05833057433719341	[398]	[470,374,335]	1	hSpCas9	negative selection	7503538
43933051	43933074	22	-	27260156	MEWO	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.0970270871710015	[122]	[172,98,106]	2	hSpCas9	negative selection	7567785
43927014	43927037	22	+	27260156	MEWO	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.11138571798651964	[862]	[1011,764,866]	2	hSpCas9	negative selection	7567786
43932948	43932971	22	-	27260156	MEWO	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.01302103236607155	[318]	[340,292,261]	0	hSpCas9	negative selection	7567787
43926974	43926997	22	-	27260156	LNCAPCLONEFGC	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.5085556667769962	[386]	[438,500,595,473]	7	hSpCas9	negative selection	7624787
43928825	43928848	22	-	27260156	LNCAPCLONEFGC	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.2061238679231967	[534]	[493,610,587,544]	3	hSpCas9	negative selection	7624788
43928876	43928899	22	-	27260156	LNCAPCLONEFGC	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	-0.21027560127317166	[398]	[212,283,404,364]	-3	hSpCas9	negative selection	7624789
43933051	43933074	22	-	27260156	LNCAPCLONEFGC	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.13090777626752548	[122]	[82,82,97,143]	-2	hSpCas9	negative selection	7689036
43927014	43927037	22	+	27260156	LNCAPCLONEFGC	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.1681165322576128	[862]	[871,865,919,861]	2	hSpCas9	negative selection	7689037
43932948	43932971	22	-	27260156	LNCAPCLONEFGC	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.31483554269258796	[318]	[166,174,392,222]	-5	hSpCas9	negative selection	7689038
43926974	43926997	22	-	27260156	PANC0327	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.7665067468024244	[386]	[625,532,532,656]	9	hSpCas9	negative selection	7746038
43928825	43928848	22	-	27260156	PANC0327	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-0.3108340061809277	[534]	[387,283,580,292]	-4	hSpCas9	negative selection	7746039
43928876	43928899	22	-	27260156	PANC0327	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.6550922801665662	[398]	[554,796,365,482]	8	hSpCas9	negative selection	7746040
43933051	43933074	22	-	27260156	PANC0327	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.022043710483130807	[122]	[95,83,124,140]	0	hSpCas9	negative selection	7810287
43927014	43927037	22	+	27260156	PANC0327	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.2736320774029015	[862]	[1025,754,1003,951]	4	hSpCas9	negative selection	7810288
43932948	43932971	22	-	27260156	PANC0327	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.4616066923095973	[318]	[168,144,286,226]	-6	hSpCas9	negative selection	7810289
43926974	43926997	22	-	27260156	NCIH2009	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.5111910436779572	[386]	[864,836,625]	7	hSpCas9	negative selection	7867289
43928825	43928848	22	-	27260156	NCIH2009	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.11920798390096371	[534]	[1199,587,726]	1	hSpCas9	negative selection	7867290
43928876	43928899	22	-	27260156	NCIH2009	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.38149435438119295	[398]	[1097,663,489]	5	hSpCas9	negative selection	7867291
43933051	43933074	22	-	27260156	NCIH2009	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.3408895480621683	[122]	[217,143,291]	5	hSpCas9	negative selection	7931538
43927014	43927037	22	+	27260156	NCIH2009	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.2868131994380376	[862]	[1607,1548,1278]	4	hSpCas9	negative selection	7931539
43932948	43932971	22	-	27260156	NCIH2009	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.3649880348491703	[318]	[372,342,326]	-5	hSpCas9	negative selection	7931540
43926974	43926997	22	-	27260156	NCIH1373	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	1.0423260637451537	[386]	[1384,341,1062,239]	9	hSpCas9	negative selection	7988540
43928825	43928848	22	-	27260156	NCIH1373	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.24048939376082612	[534]	[569,737,524,260]	2	hSpCas9	negative selection	7988541
43928876	43928899	22	-	27260156	NCIH1373	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.46152587378214116	[398]	[789,416,732,147]	4	hSpCas9	negative selection	7988542
43933051	43933074	22	-	27260156	NCIH1373	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.5645687868963285	[122]	[80,78,119,23]	-5	hSpCas9	negative selection	8052789
43927014	43927037	22	+	27260156	NCIH1373	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.3776067911428749	[862]	[1300,1261,1134,350]	4	hSpCas9	negative selection	8052790
43932948	43932971	22	-	27260156	NCIH1373	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.8567349080314651	[318]	[334,101,227,39]	-7	hSpCas9	negative selection	8052791
43926974	43926997	22	-	27260156	PATU8902	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.9154552608820092	[386]	[1000,1167,824,1127]	8	hSpCas9	negative selection	8109791
43928825	43928848	22	-	27260156	PATU8902	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.05355474618481032	[534]	[626,731,486,1390]	0	hSpCas9	negative selection	8109792
43928876	43928899	22	-	27260156	PATU8902	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.9394847780715052	[398]	[967,1000,915,1455]	8	hSpCas9	negative selection	8109793
43933051	43933074	22	-	27260156	PATU8902	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.24218126193848977	[122]	[283,233,35,309]	2	hSpCas9	negative selection	8174040
43927014	43927037	22	+	27260156	PATU8902	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.30080879617119005	[862]	[1058,1995,1090,1925]	3	hSpCas9	negative selection	8174041
43932948	43932971	22	-	27260156	PATU8902	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.2257207079901023	[318]	[708,469,315,643]	2	hSpCas9	negative selection	8174042
43926974	43926997	22	-	27260156	PANC1	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.30561486898035933	[386]	[467,412,415,348]	5	hSpCas9	negative selection	8231042
43928825	43928848	22	-	27260156	PANC1	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.291003923108781	[534]	[532,793,586,400]	5	hSpCas9	negative selection	8231043
43928876	43928899	22	-	27260156	PANC1	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	-0.07179609437194032	[398]	[436,364,286,230]	-1	hSpCas9	negative selection	8231044
43933051	43933074	22	-	27260156	PANC1	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.4406680427834835	[122]	[168,274,71,89]	7	hSpCas9	negative selection	8295291
43927014	43927037	22	+	27260156	PANC1	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.010749257877797347	[862]	[751,805,885,572]	0	hSpCas9	negative selection	8295292
43932948	43932971	22	-	27260156	PANC1	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.18643638085308178	[318]	[207,366,313,117]	-3	hSpCas9	negative selection	8295293
43926974	43926997	22	-	27260156	PANC0813	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.42214548564017174	[386]	[609,476,804,547]	6	hSpCas9	negative selection	8352293
43928825	43928848	22	-	27260156	PANC0813	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.13239168087038816	[534]	[681,929,532,611]	2	hSpCas9	negative selection	8352294
43928876	43928899	22	-	27260156	PANC0813	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.5023357562080021	[398]	[835,526,482,814]	7	hSpCas9	negative selection	8352295
43933051	43933074	22	-	27260156	PANC0813	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.4913480947850275	[122]	[252,220,149,192]	7	hSpCas9	negative selection	8416542
43927014	43927037	22	+	27260156	PANC0813	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.31005259852057354	[862]	[1447,1337,1078,1180]	5	hSpCas9	negative selection	8416543
43932948	43932971	22	-	27260156	PANC0813	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.2272516079149448	[318]	[400,317,367,206]	-4	hSpCas9	negative selection	8416544
43926974	43926997	22	-	27260156	RDES	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.7055798151958828	[386]	[561,700,641,1062]	9	hSpCas9	negative selection	8473544
43928825	43928848	22	-	27260156	RDES	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.21958691564473914	[534]	[537,636,867,878]	3	hSpCas9	negative selection	8473545
43928876	43928899	22	-	27260156	RDES	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	-0.0504324089391007	[398]	[360,329,562,555]	-1	hSpCas9	negative selection	8473546
43933051	43933074	22	-	27260156	RDES	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.16396515085560326	[122]	[79,103,169,167]	-3	hSpCas9	negative selection	8537793
43927014	43927037	22	+	27260156	RDES	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.08235411720181707	[862]	[799,813,1259,1444]	1	hSpCas9	negative selection	8537794
43932948	43932971	22	-	27260156	RDES	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.32664573249464535	[318]	[249,293,286,346]	-5	hSpCas9	negative selection	8537795
43926974	43926997	22	-	27260156	PC3	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.7510466796198554	[386]	[384,701,1319,496]	9	hSpCas9	negative selection	8594795
43928825	43928848	22	-	27260156	PC3	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.31423451795055085	[534]	[344,696,1233,681]	6	hSpCas9	negative selection	8594796
43928876	43928899	22	-	27260156	PC3	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.27264580729299853	[398]	[255,436,766,640]	6	hSpCas9	negative selection	8594797
43933051	43933074	22	-	27260156	PC3	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.08234401086690069	[122]	[80,27,215,188]	-2	hSpCas9	negative selection	8659044
43927014	43927037	22	+	27260156	PC3	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.2063474980832707	[862]	[562,1030,1877,937]	4	hSpCas9	negative selection	8659045
43932948	43932971	22	-	27260156	PC3	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.07125083475995675	[318]	[232,390,620,201]	1	hSpCas9	negative selection	8659046
43926974	43926997	22	-	27260156	PATU8988T	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.36090062696129943	[386]	[355,649,530,391]	6	hSpCas9	negative selection	8716046
43928825	43928848	22	-	27260156	PATU8988T	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.6323284322324156	[534]	[731,815,922,727]	9	hSpCas9	negative selection	8716047
43928876	43928899	22	-	27260156	PATU8988T	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.02167336566049846	[398]	[338,472,422,332]	0	hSpCas9	negative selection	8716048
43933051	43933074	22	-	27260156	PATU8988T	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.07066862584919376	[122]	[157,124,92,74]	-1	hSpCas9	negative selection	8780295
43927014	43927037	22	+	27260156	PATU8988T	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.24666669520372775	[862]	[915,1073,911,1070]	4	hSpCas9	negative selection	8780296
43932948	43932971	22	-	27260156	PATU8988T	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.04596386013687359	[318]	[188,434,247,420]	0	hSpCas9	negative selection	8780297
43926974	43926997	22	-	27260156	T47D	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.4983916588269091	[386]	[613,549,690,700]	9	hSpCas9	negative selection	8837297
43928825	43928848	22	-	27260156	T47D	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.1319770115902691	[534]	[772,495,785,691]	3	hSpCas9	negative selection	8837298
43928876	43928899	22	-	27260156	T47D	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.17246517458987584	[398]	[568,461,534,534]	3	hSpCas9	negative selection	8837299
43933051	43933074	22	-	27260156	T47D	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.16930130935406273	[122]	[167,162,141,171]	3	hSpCas9	negative selection	8901546
43927014	43927037	22	+	27260156	T47D	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.274108305581815	[862]	[1245,1177,1141,1303]	6	hSpCas9	negative selection	8901547
43932948	43932971	22	-	27260156	T47D	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.17910266158720056	[318]	[308,371,348,276]	-4	hSpCas9	negative selection	8901548
43926974	43926997	22	-	27260156	SU8686	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.40272426380016263	[386]	[470,487,401,698]	6	hSpCas9	negative selection	8958548
43928825	43928848	22	-	27260156	SU8686	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.15585550664367426	[534]	[599,569,557,639]	2	hSpCas9	negative selection	8958549
43928876	43928899	22	-	27260156	SU8686	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.43884962791952553	[398]	[395,609,651,483]	7	hSpCas9	negative selection	8958550
43933051	43933074	22	-	27260156	SU8686	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.009581187292831306	[122]	[76,128,147,136]	0	hSpCas9	negative selection	9022797
43927014	43927037	22	+	27260156	SU8686	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.39250572218629176	[862]	[968,975,1190,1437]	6	hSpCas9	negative selection	9022798
43932948	43932971	22	-	27260156	SU8686	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.0755433247727687	[318]	[281,264,331,331]	-1	hSpCas9	negative selection	9022799
43926974	43926997	22	-	27260156	SKES1	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.44298128390727465	[386]	[426,509,583,552]	8	hSpCas9	negative selection	9079799
43928825	43928848	22	-	27260156	SKES1	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.15178592153218562	[534]	[626,750,541,482]	3	hSpCas9	negative selection	9079800
43928876	43928899	22	-	27260156	SKES1	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.13711608965671945	[398]	[663,409,404,310]	3	hSpCas9	negative selection	9079801
43933051	43933074	22	-	27260156	SKES1	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.3983423294944122	[122]	[37,119,118,89]	-7	hSpCas9	negative selection	9144048
43927014	43927037	22	+	27260156	SKES1	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.060821168714246254	[862]	[966,977,892,777]	1	hSpCas9	negative selection	9144049
43932948	43932971	22	-	27260156	SKES1	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.29338320894748504	[318]	[443,335,357,415]	6	hSpCas9	negative selection	9144050
43926974	43926997	22	-	27260156	TOV112D	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.43879056511860226	[386]	[533,766,412,448]	7	hSpCas9	negative selection	9201050
43928825	43928848	22	-	27260156	TOV112D	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.30690857237401015	[534]	[511,1041,734,447]	6	hSpCas9	negative selection	9201051
43928876	43928899	22	-	27260156	TOV112D	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.13481456833157748	[398]	[273,748,434,360]	2	hSpCas9	negative selection	9201052
43933051	43933074	22	-	27260156	TOV112D	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.003172728829436977	[122]	[86,197,175,49]	0	hSpCas9	negative selection	9265299
43927014	43927037	22	+	27260156	TOV112D	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.34062497092906985	[862]	[1044,1789,1003,714]	6	hSpCas9	negative selection	9265300
43932948	43932971	22	-	27260156	TOV112D	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.24620570248329643	[318]	[454,602,222,297]	5	hSpCas9	negative selection	9265301
43926974	43926997	22	-	27260156	TC71	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.3798587851231931	[386]	[362,588,536,682]	8	hSpCas9	negative selection	9322301
43928825	43928848	22	-	27260156	TC71	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.26632672720790346	[534]	[615,797,584,769]	6	hSpCas9	negative selection	9322302
43928876	43928899	22	-	27260156	TC71	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	0.34336684015461794	[398]	[528,480,559,603]	7	hSpCas9	negative selection	9322303
43933051	43933074	22	-	27260156	TC71	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	0.08720429451460165	[122]	[141,157,138,119]	2	hSpCas9	negative selection	9386550
43927014	43927037	22	+	27260156	TC71	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.1659892864305974	[862]	[942,1064,929,1230]	4	hSpCas9	negative selection	9386551
43932948	43932971	22	-	27260156	TC71	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	0.0013726344559920056	[318]	[349,317,331,370]	0	hSpCas9	negative selection	9386552
43926974	43926997	22	-	27260156	TC32	viability	GATGCCAATGTTCCGACTCCTGG	PNPLA3	ENSG00000100344	0.6693959594675981	[386]	[461,566,647,633]	9	hSpCas9	negative selection	9443552
43928825	43928848	22	-	27260156	TC32	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.37206405800337167	[534]	[638,626,807,515]	6	hSpCas9	negative selection	9443553
43928876	43928899	22	-	27260156	TC32	viability	CCGACTTACCACGCCTCTGAAGG	PNPLA3	ENSG00000100344	-0.11893595638694046	[398]	[313,318,393,354]	-2	hSpCas9	negative selection	9443554
43933051	43933074	22	-	27260156	TC32	viability	GGACAAAAGCTCTCGAGAGAAGG	PNPLA3	ENSG00000100344	-0.13287117157972306	[122]	[128,62,89,145]	-2	hSpCas9	negative selection	9507801
43927014	43927037	22	+	27260156	TC32	viability	CTTAAGCAAGTTCCTCCGACAGG	PNPLA3	ENSG00000100344	0.15613502594187212	[862]	[851,646,1315,922]	3	hSpCas9	negative selection	9507802
43932948	43932971	22	-	27260156	TC32	viability	GATGTCGTACTCCCCATAGAAGG	PNPLA3	ENSG00000100344	-0.1230718788555979	[318]	[195,253,279,378]	-2	hSpCas9	negative selection	9507803
43923909	43923932	22	+	27869803	HPAFII	viability after 27 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-0.2032593390932207	[431]	[169,219,NaN]	-1	hSpCas9	negative selection	9581277
43927015	43927038	22	+	27869803	HPAFII	viability after 27 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.11620454737146846	[443]	[258,178,NaN]	-1	hSpCas9	negative selection	9581278
43928869	43928892	22	-	27869803	HPAFII	viability after 27 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-1.65286656522296	[86]	[7,19,NaN]	-8	hSpCas9	negative selection	9581279
43933073	43933096	22	-	27869803	HPAFII	viability after 27 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	0.20604490077910337	[309]	[163,207,NaN]	1	hSpCas9	negative selection	9581280
43937120	43937143	22	-	27869803	HPAFII	viability after 27 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	0.9196578916823964	[248]	[209,278,NaN]	7	hSpCas9	negative selection	9581281
43940104	43940127	22	+	27869803	HPAFII	viability after 27 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.42355154891470476	[371]	[171,123,NaN]	-3	hSpCas9	negative selection	9581282
43923909	43923932	22	+	27869803	HPAFII	viability after 15 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.025977504011680974	[431]	[497,456,NaN]	0	hSpCas9	negative selection	9663726
43927015	43927038	22	+	27869803	HPAFII	viability after 15 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.2193997769317787	[443]	[623,512,NaN]	2	hSpCas9	negative selection	9663727
43928869	43928892	22	-	27869803	HPAFII	viability after 15 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-0.8483419454307715	[86]	[46,54,NaN]	-7	hSpCas9	negative selection	9663728
43933073	43933096	22	-	27869803	HPAFII	viability after 15 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-0.38458620409253014	[309]	[306,222,NaN]	-4	hSpCas9	negative selection	9663729
43937120	43937143	22	-	27869803	HPAFII	viability after 15 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	0.49737583075394465	[248]	[378,376,NaN]	6	hSpCas9	negative selection	9663730
43940104	43940127	22	+	27869803	HPAFII	viability after 15 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	0.19964478367120053	[371]	[661,332,NaN]	2	hSpCas9	negative selection	9663731
43923909	43923932	22	+	27869803	ASPC1	viability after 36 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-0.14170979091062674	[1150]	[583,279,272]	-1	hSpCas9	negative selection	9746175
43927015	43927038	22	+	27869803	ASPC1	viability after 36 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	0.48248474037055944	[1553]	[283,804,1044]	5	hSpCas9	negative selection	9746176
43928869	43928892	22	-	27869803	ASPC1	viability after 36 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	0.00020266135907398564	[210]	[35,0,156]	0	hSpCas9	negative selection	9746177
43933073	43933096	22	-	27869803	ASPC1	viability after 36 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-1.065846619400746	[717]	[26,200,118]	-7	hSpCas9	negative selection	9746178
43937120	43937143	22	-	27869803	ASPC1	viability after 36 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	-0.8109844046599791	[537]	[249,30,65]	-7	hSpCas9	negative selection	9746179
43940104	43940127	22	+	27869803	ASPC1	viability after 36 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	0.4679524989372644	[982]	[659,628,216]	5	hSpCas9	negative selection	9746180
43923909	43923932	22	+	27869803	PATU8988S	viability after 35 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.003806439819269536	[950]	[395,371,NaN]	0	hSpCas9	negative selection	9828624
43927015	43927038	22	+	27869803	PATU8988S	viability after 35 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.6204172224125646	[1381]	[387,335,NaN]	-6	hSpCas9	negative selection	9828625
43928869	43928892	22	-	27869803	PATU8988S	viability after 35 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-0.34473280552509245	[267]	[82,86,NaN]	-4	hSpCas9	negative selection	9828626
43933073	43933096	22	-	27869803	PATU8988S	viability after 35 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-1.105149821126485	[790]	[187,107,NaN]	-8	hSpCas9	negative selection	9828627
43937120	43937143	22	-	27869803	PATU8988S	viability after 35 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	0.19981405410669828	[512]	[150,323,NaN]	2	hSpCas9	negative selection	9828628
43940104	43940127	22	+	27869803	PATU8988S	viability after 35 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	0.8112469280967773	[759]	[801,270,NaN]	8	hSpCas9	negative selection	9828629
43923909	43923932	22	+	27869803	PATU8988S	viability after 31 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.051501216680796436	[950]	[326,476,NaN]	0	hSpCas9	negative selection	9911073
43927015	43927038	22	+	27869803	PATU8988S	viability after 31 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.6568184243759486	[1381]	[378,311,NaN]	-6	hSpCas9	negative selection	9911074
43928869	43928892	22	-	27869803	PATU8988S	viability after 31 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-1.320067820578123	[267]	[44,39,NaN]	-8	hSpCas9	negative selection	9911075
43933073	43933096	22	-	27869803	PATU8988S	viability after 31 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	-1.0670014767268001	[790]	[84,233,NaN]	-8	hSpCas9	negative selection	9911076
43937120	43937143	22	-	27869803	PATU8988S	viability after 31 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	-0.32733871665519393	[512]	[122,213,NaN]	-4	hSpCas9	negative selection	9911077
43940104	43940127	22	+	27869803	PATU8988S	viability after 31 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	0.4696492865642472	[759]	[460,366,NaN]	5	hSpCas9	negative selection	9911078
43923909	43923932	22	+	27869803	HPAFII	viability after 35 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.028382205270610084	[431]	[72,391,NaN]	0	hSpCas9	negative selection	9993522
43927015	43927038	22	+	27869803	HPAFII	viability after 35 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.4251443445645978	[443]	[149,186,NaN]	-3	hSpCas9	negative selection	9993523
43928869	43928892	22	-	27869803	HPAFII	viability after 35 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-3.0731611107391457	[86]	[0,9,NaN]	-8	hSpCas9	negative selection	9993524
43933073	43933096	22	-	27869803	HPAFII	viability after 35 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	0.0030888516092272833	[309]	[113,205,NaN]	0	hSpCas9	negative selection	9993525
43937120	43937143	22	-	27869803	HPAFII	viability after 35 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	1.3062637762814773	[248]	[132,512,NaN]	8	hSpCas9	negative selection	9993526
43940104	43940127	22	+	27869803	HPAFII	viability after 35 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.2085170332562753	[371]	[241,73,NaN]	-1	hSpCas9	negative selection	9993527
43923909	43923932	22	+	27869803	HPAFII	viability after 31 days	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.0744526944956756	[431]	[149,369,NaN]	0	hSpCas9	negative selection	10075971
43927015	43927038	22	+	27869803	HPAFII	viability after 31 days	TTAAGCAAGTTCCTCCGACAGGG	PNPLA3	ENSG00000100344	-0.20144177019329212	[443]	[198,235,NaN]	-1	hSpCas9	negative selection	10075972
43928869	43928892	22	-	27869803	HPAFII	viability after 31 days	ACCACGCCTCTGAAGGAAGGAGG	PNPLA3	ENSG00000100344	-2.256047356391769	[86]	[3,16,NaN]	-8	hSpCas9	negative selection	10075973
43933073	43933096	22	-	27869803	HPAFII	viability after 31 days	CAACTCACCTTGAGATCCGGGGG	PNPLA3	ENSG00000100344	0.36358926654946716	[309]	[130,324,NaN]	2	hSpCas9	negative selection	10075974
43937120	43937143	22	-	27869803	HPAFII	viability after 31 days	CAGACTCATGTTTGCCCAGCTGG	PNPLA3	ENSG00000100344	1.4376821031339153	[248]	[211,559,NaN]	9	hSpCas9	negative selection	10075975
43940104	43940127	22	+	27869803	HPAFII	viability after 31 days	CTGCCATTGCGATTGTCCAGAGG	PNPLA3	ENSG00000100344	-0.11664478113314541	[371]	[271,105,NaN]	-1	hSpCas9	negative selection	10075976
43923943	43923966	22	-	28162770	P31FUJ	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	-0.6478397036932225	[231]	[173]	-5	hSpCas9	negative selection	10213703
43932872	43932895	22	+	28162770	P31FUJ	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.7637858230669028	[634]	[1266]	8	hSpCas9	negative selection	10213704
43924019	43924042	22	-	28162770	P31FUJ	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	0.7102078170007915	[141]	[272]	7	hSpCas9	negative selection	10213705
43933030	43933053	22	-	28162770	P31FUJ	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.3207961253974425	[247]	[363]	3	hSpCas9	negative selection	10213706
43937079	43937102	22	+	28162770	P31FUJ	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	0.33508678294783606	[169]	[251]	3	hSpCas9	negative selection	10213707
43937220	43937243	22	-	28162770	P31FUJ	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	0.5556936903919094	[43]	[75]	6	hSpCas9	negative selection	10213708
43923909	43923932	22	+	28162770	P31FUJ	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.518078136330455	[453]	[763]	6	hSpCas9	negative selection	10213709
43923989	43924012	22	-	28162770	P31FUJ	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	-0.3036235416040754	[166]	[158]	-3	hSpCas9	negative selection	10213710
43927050	43927073	22	-	28162770	P31FUJ	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	0.5041633897518276	[197]	[329]	6	hSpCas9	negative selection	10213711
43928825	43928848	22	-	28162770	P31FUJ	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.5638385664117757	[250]	[435]	6	hSpCas9	negative selection	10213712
43923943	43923966	22	-	28162770	TF1	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	NaN	[NaN]	[211]	1	hSpCas9	negative selection	10383069
43932872	43932895	22	+	28162770	TF1	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	NaN	[NaN]	[753]	1	hSpCas9	negative selection	10383070
43924019	43924042	22	-	28162770	TF1	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	NaN	[NaN]	[214]	1	hSpCas9	negative selection	10383071
43933030	43933053	22	-	28162770	TF1	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	NaN	[NaN]	[168]	1	hSpCas9	negative selection	10383072
43937079	43937102	22	+	28162770	TF1	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	NaN	[NaN]	[149]	1	hSpCas9	negative selection	10383073
43937220	43937243	22	-	28162770	TF1	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	NaN	[NaN]	[64]	1	hSpCas9	negative selection	10383074
43923909	43923932	22	+	28162770	TF1	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	NaN	[NaN]	[489]	1	hSpCas9	negative selection	10383075
43923989	43924012	22	-	28162770	TF1	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	NaN	[NaN]	[173]	1	hSpCas9	negative selection	10383076
43927050	43927073	22	-	28162770	TF1	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	NaN	[NaN]	[315]	1	hSpCas9	negative selection	10383077
43928825	43928848	22	-	28162770	TF1	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	NaN	[NaN]	[152]	1	hSpCas9	negative selection	10383078
43923943	43923966	22	-	28162770	SKM1	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	0.03256786245643062	[72]	[131]	0	hSpCas9	negative selection	10552435
43932872	43932895	22	+	28162770	SKM1	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.0741624909934544	[143]	[267]	0	hSpCas9	negative selection	10552436
43924019	43924042	22	-	28162770	SKM1	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	0.6634251291482363	[29]	[83]	6	hSpCas9	negative selection	10552437
43933030	43933053	22	-	28162770	SKM1	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.5694232440348876	[76]	[201]	5	hSpCas9	negative selection	10552438
43937079	43937102	22	+	28162770	SKM1	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	-0.5153403597879537	[75]	[93]	-4	hSpCas9	negative selection	10552439
43937220	43937243	22	-	28162770	SKM1	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	-0.3783950465463908	[24]	[33]	-3	hSpCas9	negative selection	10552440
43923909	43923932	22	+	28162770	SKM1	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	1.0479377614136214	[86]	[317]	8	hSpCas9	negative selection	10552441
43923989	43924012	22	-	28162770	SKM1	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	-0.9289169019385176	[41]	[38]	-6	hSpCas9	negative selection	10552442
43927050	43927073	22	-	28162770	SKM1	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	0.22862437504796249	[41]	[86]	2	hSpCas9	negative selection	10552443
43928825	43928848	22	-	28162770	SKM1	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.14628944225065615	[68]	[134]	1	hSpCas9	negative selection	10552444
43923943	43923966	22	-	28162770	SKM1	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	0.03256786245643062	[72]	[131]	0	hSpCas9	negative selection	10721801
43932872	43932895	22	+	28162770	SKM1	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.0741624909934544	[143]	[267]	0	hSpCas9	negative selection	10721802
43924019	43924042	22	-	28162770	SKM1	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	0.6634251291482363	[29]	[83]	6	hSpCas9	negative selection	10721803
43933030	43933053	22	-	28162770	SKM1	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.5694232440348876	[76]	[201]	5	hSpCas9	negative selection	10721804
43937079	43937102	22	+	28162770	SKM1	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	-0.5153403597879537	[75]	[93]	-4	hSpCas9	negative selection	10721805
43937220	43937243	22	-	28162770	SKM1	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	-0.3783950465463908	[24]	[33]	-3	hSpCas9	negative selection	10721806
43923909	43923932	22	+	28162770	SKM1	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	1.0479377614136214	[86]	[317]	8	hSpCas9	negative selection	10721807
43923989	43924012	22	-	28162770	SKM1	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	-0.9289169019385176	[41]	[38]	-6	hSpCas9	negative selection	10721808
43927050	43927073	22	-	28162770	SKM1	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	0.22862437504796249	[41]	[86]	2	hSpCas9	negative selection	10721809
43928825	43928848	22	-	28162770	SKM1	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.14628944225065615	[68]	[134]	1	hSpCas9	negative selection	10721810
43923943	43923966	22	-	28162770	PL21	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	0.5315191847212546	[212]	[133]	4	hSpCas9	negative selection	10891167
43932872	43932895	22	+	28162770	PL21	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.24818051403124564	[442]	[228]	2	hSpCas9	negative selection	10891168
43924019	43924042	22	-	28162770	PL21	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	0.5815687211253442	[151]	[98]	5	hSpCas9	negative selection	10891169
43933030	43933053	22	-	28162770	PL21	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.1762928725349523	[243]	[119]	1	hSpCas9	negative selection	10891170
43937079	43937102	22	+	28162770	PL21	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	1.0036006204424335	[211]	[184]	8	hSpCas9	negative selection	10891171
43937220	43937243	22	-	28162770	PL21	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	2.4277403268285296	[78]	[184]	9	hSpCas9	negative selection	10891172
43923909	43923932	22	+	28162770	PL21	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.9326593036243341	[324]	[269]	7	hSpCas9	negative selection	10891173
43923989	43924012	22	-	28162770	PL21	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	-0.34919897650111476	[119]	[40]	-3	hSpCas9	negative selection	10891174
43927050	43927073	22	-	28162770	PL21	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	0.9522121010457345	[132]	[111]	7	hSpCas9	negative selection	10891175
43928825	43928848	22	-	28162770	PL21	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.4255597285233361	[271]	[158]	4	hSpCas9	negative selection	10891176
43923943	43923966	22	-	28162770	P31FUJ	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	-0.6478397036932225	[231]	[173]	-5	hSpCas9	negative selection	11060533
43932872	43932895	22	+	28162770	P31FUJ	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.7637858230669028	[634]	[1266]	8	hSpCas9	negative selection	11060534
43924019	43924042	22	-	28162770	P31FUJ	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	0.7102078170007915	[141]	[272]	7	hSpCas9	negative selection	11060535
43933030	43933053	22	-	28162770	P31FUJ	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.3207961253974425	[247]	[363]	3	hSpCas9	negative selection	11060536
43937079	43937102	22	+	28162770	P31FUJ	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	0.33508678294783606	[169]	[251]	3	hSpCas9	negative selection	11060537
43937220	43937243	22	-	28162770	P31FUJ	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	0.5556936903919094	[43]	[75]	6	hSpCas9	negative selection	11060538
43923909	43923932	22	+	28162770	P31FUJ	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.518078136330455	[453]	[763]	6	hSpCas9	negative selection	11060539
43923989	43924012	22	-	28162770	P31FUJ	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	-0.3036235416040754	[166]	[158]	-3	hSpCas9	negative selection	11060540
43927050	43927073	22	-	28162770	P31FUJ	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	0.5041633897518276	[197]	[329]	6	hSpCas9	negative selection	11060541
43928825	43928848	22	-	28162770	P31FUJ	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.5638385664117757	[250]	[435]	6	hSpCas9	negative selection	11060542
43923943	43923966	22	-	28162770	OCIAML5	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	0.48183416568944126	[95]	[241]	4	hSpCas9	negative selection	11229899
43932872	43932895	22	+	28162770	OCIAML5	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.4549699708885644	[408]	[1011]	4	hSpCas9	negative selection	11229900
43924019	43924042	22	-	28162770	OCIAML5	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	0.8398111337736711	[51]	[167]	7	hSpCas9	negative selection	11229901
43933030	43933053	22	-	28162770	OCIAML5	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.04901840306331573	[82]	[154]	0	hSpCas9	negative selection	11229902
43937079	43937102	22	+	28162770	OCIAML5	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	0.12521335263591946	[127]	[251]	1	hSpCas9	negative selection	11229903
43937220	43937243	22	-	28162770	OCIAML5	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	-4.437029071585153	[47]	[3]	-9	hSpCas9	negative selection	11229904
43923909	43923932	22	+	28162770	OCIAML5	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.3301367603567522	[207]	[471]	3	hSpCas9	negative selection	11229905
43923989	43924012	22	-	28162770	OCIAML5	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	0.48025312986996094	[82]	[208]	4	hSpCas9	negative selection	11229906
43927050	43927073	22	-	28162770	OCIAML5	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	0.35383772768388194	[87]	[202]	3	hSpCas9	negative selection	11229907
43928825	43928848	22	-	28162770	OCIAML5	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.12266667052557295	[143]	[282]	1	hSpCas9	negative selection	11229908
43923943	43923966	22	-	28162770	EOL1	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	-0.10647912405008986	[422]	[206]	-1	hSpCas9	negative selection	11399265
43932872	43932895	22	+	28162770	EOL1	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.0042260267762621595	[633]	[334]	0	hSpCas9	negative selection	11399266
43924019	43924042	22	-	28162770	EOL1	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	1.2453699292317277	[260]	[325]	9	hSpCas9	negative selection	11399267
43933030	43933053	22	-	28162770	EOL1	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	-0.21736285370218128	[458]	[207]	-2	hSpCas9	negative selection	11399268
43937079	43937102	22	+	28162770	EOL1	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	-0.35343697572923066	[387]	[159]	-3	hSpCas9	negative selection	11399269
43937220	43937243	22	-	28162770	EOL1	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	-2.3888688234613102	[168]	[16]	-8	hSpCas9	negative selection	11399270
43923909	43923932	22	+	28162770	EOL1	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	1.3453908925305842	[371]	[497]	9	hSpCas9	negative selection	11399271
43923989	43924012	22	-	28162770	EOL1	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	-0.5405749591446185	[126]	[45]	-4	hSpCas9	negative selection	11399272
43927050	43927073	22	-	28162770	EOL1	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	0.7244081570812144	[192]	[167]	6	hSpCas9	negative selection	11399273
43928825	43928848	22	-	28162770	EOL1	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.7858415007389423	[239]	[217]	7	hSpCas9	negative selection	11399274
43923943	43923966	22	-	28162770	MOLM13	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	0.5233844941362826	[254]	[264]	4	hSpCas9	negative selection	11568631
43932872	43932895	22	+	28162770	MOLM13	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.08854358940904383	[691]	[531]	0	hSpCas9	negative selection	11568632
43924019	43924042	22	-	28162770	MOLM13	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	1.3349951110472333	[249]	[455]	8	hSpCas9	negative selection	11568633
43933030	43933053	22	-	28162770	MOLM13	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.3200439135731848	[307]	[277]	2	hSpCas9	negative selection	11568634
43937079	43937102	22	+	28162770	MOLM13	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	0.49723334312672324	[291]	[297]	3	hSpCas9	negative selection	11568635
43937220	43937243	22	-	28162770	MOLM13	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	0.41681519695030966	[114]	[110]	3	hSpCas9	negative selection	11568636
43923909	43923932	22	+	28162770	MOLM13	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-0.2529565472583504	[444]	[269]	-1	hSpCas9	negative selection	11568637
43923989	43924012	22	-	28162770	MOLM13	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	-0.5509696457067371	[153]	[75]	-3	hSpCas9	negative selection	11568638
43927050	43927073	22	-	28162770	MOLM13	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	-0.14508749534617416	[181]	[118]	-1	hSpCas9	negative selection	11568639
43928825	43928848	22	-	28162770	MOLM13	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-0.7545030397918691	[384]	[164]	-4	hSpCas9	negative selection	11568640
43923943	43923966	22	-	28162770	HEL	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	0.23475609025546348	[271]	[204]	2	hSpCas9	negative selection	11737997
43932872	43932895	22	+	28162770	HEL	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.2867028827927305	[534]	[417]	2	hSpCas9	negative selection	11737998
43924019	43924042	22	-	28162770	HEL	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	0.32319732994987244	[150]	[120]	2	hSpCas9	negative selection	11737999
43933030	43933053	22	-	28162770	HEL	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.6770903367911338	[331]	[339]	6	hSpCas9	negative selection	11738000
43937079	43937102	22	+	28162770	HEL	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	1.179446164114292	[303]	[440]	9	hSpCas9	negative selection	11738001
43937220	43937243	22	-	28162770	HEL	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	-0.21524216312721522	[115]	[63]	-1	hSpCas9	negative selection	11738002
43923909	43923932	22	+	28162770	HEL	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.8683479660203477	[383]	[448]	7	hSpCas9	negative selection	11738003
43923989	43924012	22	-	28162770	HEL	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	1.4089987329606015	[116]	[198]	9	hSpCas9	negative selection	11738004
43927050	43927073	22	-	28162770	HEL	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	0.4851975550138768	[173]	[155]	4	hSpCas9	negative selection	11738005
43928825	43928848	22	-	28162770	HEL	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-0.3720077533688295	[294]	[145]	-3	hSpCas9	negative selection	11738006
43923943	43923966	22	-	28162770	MV411	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	-0.31105273857718985	[242]	[164]	-2	hSpCas9	negative selection	11907363
43932872	43932895	22	+	28162770	MV411	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.4170117449185835	[456]	[513]	4	hSpCas9	negative selection	11907364
43924019	43924042	22	-	28162770	MV411	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	-0.1428775190848372	[134]	[102]	-1	hSpCas9	negative selection	11907365
43933030	43933053	22	-	28162770	MV411	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.31720782908694944	[221]	[232]	3	hSpCas9	negative selection	11907366
43937079	43937102	22	+	28162770	MV411	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	0.4196185261654557	[212]	[239]	4	hSpCas9	negative selection	11907367
43937220	43937243	22	-	28162770	MV411	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	0.5052353082504222	[45]	[54]	4	hSpCas9	negative selection	11907368
43923909	43923932	22	+	28162770	MV411	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-0.2989903485193914	[313]	[214]	-2	hSpCas9	negative selection	11907369
43923989	43924012	22	-	28162770	MV411	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	0.8285477260083249	[124]	[186]	7	hSpCas9	negative selection	11907370
43927050	43927073	22	-	28162770	MV411	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	0.2866081480634531	[108]	[111]	2	hSpCas9	negative selection	11907371
43928825	43928848	22	-	28162770	MV411	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.5406339271268216	[141]	[173]	5	hSpCas9	negative selection	11907372
43923943	43923966	22	-	28162770	MONOMAC1	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	-0.43333487042121993	[138]	[117]	-4	hSpCas9	negative selection	12076729
43932872	43932895	22	+	28162770	MONOMAC1	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.015078095081067389	[321]	[372]	0	hSpCas9	negative selection	12076730
43924019	43924042	22	-	28162770	MONOMAC1	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	-0.21431483849138944	[83]	[82]	-2	hSpCas9	negative selection	12076731
43933030	43933053	22	-	28162770	MONOMAC1	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.2465698044160609	[174]	[237]	2	hSpCas9	negative selection	12076732
43937079	43937102	22	+	28162770	MONOMAC1	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	-0.014833515838804712	[155]	[176]	0	hSpCas9	negative selection	12076733
43937220	43937243	22	-	28162770	MONOMAC1	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	-0.31733108077726535	[49]	[45]	-3	hSpCas9	negative selection	12076734
43923909	43923932	22	+	28162770	MONOMAC1	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	-0.008459138715349535	[221]	[252]	0	hSpCas9	negative selection	12076735
43923989	43924012	22	-	28162770	MONOMAC1	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	0.6801064051549129	[48]	[89]	6	hSpCas9	negative selection	12076736
43927050	43927073	22	-	28162770	MONOMAC1	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	-0.46748872445583045	[116]	[96]	-4	hSpCas9	negative selection	12076737
43928825	43928848	22	-	28162770	MONOMAC1	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-0.05019545873028264	[139]	[154]	0	hSpCas9	negative selection	12076738
43923943	43923966	22	-	28162770	OCIAML2	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	0.7148499903949929	[40]	[372]	7	hSpCas9	negative selection	12246095
43932872	43932895	22	+	28162770	OCIAML2	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.7852090791874285	[66]	[639]	7	hSpCas9	negative selection	12246096
43924019	43924042	22	-	28162770	OCIAML2	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	0.013185952022095326	[31]	[178]	0	hSpCas9	negative selection	12246097
43933030	43933053	22	-	28162770	OCIAML2	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.36536514485934424	[56]	[406]	3	hSpCas9	negative selection	12246098
43937079	43937102	22	+	28162770	OCIAML2	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	-0.011198206604863925	[43]	[241]	0	hSpCas9	negative selection	12246099
43937220	43937243	22	-	28162770	OCIAML2	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	-0.21189555684199313	[13]	[66]	-2	hSpCas9	negative selection	12246100
43923909	43923932	22	+	28162770	OCIAML2	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.2852654974588962	[52]	[357]	2	hSpCas9	negative selection	12246101
43923989	43924012	22	-	28162770	OCIAML2	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	0.5766758895361955	[14]	[123]	5	hSpCas9	negative selection	12246102
43927050	43927073	22	-	28162770	OCIAML2	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	0.5824815112174012	[19]	[165]	5	hSpCas9	negative selection	12246103
43928825	43928848	22	-	28162770	OCIAML2	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	0.3159665366486454	[49]	[344]	3	hSpCas9	negative selection	12246104
43923943	43923966	22	-	28162770	OCIAML3	viability	CAGGAAGCCGCAGCCCGCGAAGG	PNPLA3	ENSG00000100344	-0.08499399283630549	[51]	[147]	0	hSpCas9	negative selection	12415461
43932872	43932895	22	+	28162770	OCIAML3	viability	TAAAAGCGATATGTGGATGGAGG	PNPLA3	ENSG00000100344	0.9267429571798911	[133]	[768]	7	hSpCas9	negative selection	12415462
43924019	43924042	22	-	28162770	OCIAML3	viability	ACAACATGCGCGCGTCGCGGAGG	PNPLA3	ENSG00000100344	-0.813788848204073	[45]	[78]	-6	hSpCas9	negative selection	12415463
43933030	43933053	22	-	28162770	OCIAML3	viability	GGTAGAGGTTCCCTGTGCAGAGG	PNPLA3	ENSG00000100344	0.5301136715050243	[63]	[278]	5	hSpCas9	negative selection	12415464
43937079	43937102	22	+	28162770	OCIAML3	viability	GAAGTCATCCTCAGAAGGGATGG	PNPLA3	ENSG00000100344	0.14921694431372545	[68]	[230]	1	hSpCas9	negative selection	12415465
43937220	43937243	22	-	28162770	OCIAML3	viability	GGATGCTCTCATCCCAGGGCAGG	PNPLA3	ENSG00000100344	-0.231437560939455	[20]	[53]	-2	hSpCas9	negative selection	12415466
43923909	43923932	22	+	28162770	OCIAML3	viability	GCCATGTACGACGCAGAGCGCGG	PNPLA3	ENSG00000100344	0.3844054974676908	[100]	[397]	3	hSpCas9	negative selection	12415467
43923989	43924012	22	-	28162770	OCIAML3	viability	GGGCGTGCTCGCTCAGGCAGCGG	PNPLA3	ENSG00000100344	1.2722409707870095	[23]	[174]	9	hSpCas9	negative selection	12415468
43927050	43927073	22	-	28162770	OCIAML3	viability	GCTGGTGGACATTGGCCGGGAGG	PNPLA3	ENSG00000100344	-0.3412415699441966	[46]	[111]	-3	hSpCas9	negative selection	12415469
43928825	43928848	22	-	28162770	OCIAML3	viability	GATGAAGCAGGAACATACCAAGG	PNPLA3	ENSG00000100344	-1.707218250772154	[52]	[48]	-8	hSpCas9	negative selection	12415470