Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 5621
• Symbol: PRNP
• Description: prion protein (Kanno blood group)

DataSource: http://genomecrispr.dkfz.de/#!/results/PRNP

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
4699782	4699805	20	+	26472758	Jiyoye	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	1.2538789710393028	[123]	[222]	7	hSpCas9	negative selection	127716
4699261	4699284	20	-	26472758	Jiyoye	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	0.6922667082128644	[118]	[144]	5	hSpCas9	negative selection	127717
4699932	4699955	20	-	26472758	Jiyoye	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-1.914752713381489	[34]	[6]	-8	hSpCas9	negative selection	127718
4699287	4699310	20	+	26472758	Jiyoye	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	-0.01617738598497409	[231]	[172]	0	hSpCas9	negative selection	127719
4699448	4699471	20	-	26472758	Jiyoye	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	-0.12023609665312418	[257]	[178]	-1	hSpCas9	negative selection	127720
4699476	4699499	20	+	26472758	Jiyoye	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-0.9589525172920238	[115]	[44]	-6	hSpCas9	negative selection	127721
4699495	4699518	20	+	26472758	Jiyoye	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	-0.16820107038608467	[224]	[150]	-1	hSpCas9	negative selection	127722
4699822	4699845	20	-	26472758	Jiyoye	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.4071753815058732	[131]	[131]	3	hSpCas9	negative selection	127723
4699859	4699882	20	+	26472758	Jiyoye	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-0.8511366140855172	[121]	[50]	-5	hSpCas9	negative selection	127724
4699229	4699252	20	-	26472758	Jiyoye	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.32917286950460023	[75]	[71]	2	hSpCas9	negative selection	127725
4699782	4699805	20	+	26472758	KBM7	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	0.454038540878968	[1058,719]	[525,598]	5	hSpCas9	negative selection	318834
4699261	4699284	20	-	26472758	KBM7	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	0.15760615647856446	[724,539]	[292,359]	1	hSpCas9	negative selection	318835
4699932	4699955	20	-	26472758	KBM7	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-1.2875748663994688	[204,108]	[39,19]	-7	hSpCas9	negative selection	318836
4699287	4699310	20	+	26472758	KBM7	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	-0.0955592609222524	[765,371]	[190,288]	-1	hSpCas9	negative selection	318837
4699448	4699471	20	-	26472758	KBM7	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	0.6540037489146857	[941,665]	[628,549]	7	hSpCas9	negative selection	318838
4699476	4699499	20	+	26472758	KBM7	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-0.648698264794261	[535,324]	[116,134]	-5	hSpCas9	negative selection	318839
4699495	4699518	20	+	26472758	KBM7	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.6881730612410831	[761,619]	[500,537]	7	hSpCas9	negative selection	318840
4699822	4699845	20	-	26472758	KBM7	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.1640628809791833	[939,926]	[461,331]	-1	hSpCas9	negative selection	318841
4699859	4699882	20	+	26472758	KBM7	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-1.0081160485937213	[337,303]	[74,74]	-7	hSpCas9	negative selection	318842
4699229	4699252	20	-	26472758	KBM7	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.06062887391042182	[449,458]	[182,260]	0	hSpCas9	negative selection	318843
4699782	4699805	20	+	26472758	Raji	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	1.005503921354386	[263]	[122]	8	hSpCas9	negative selection	509952
4699261	4699284	20	-	26472758	Raji	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	0.07175962564287824	[327]	[79]	0	hSpCas9	negative selection	509953
4699932	4699955	20	-	26472758	Raji	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-0.1594030053213018	[76]	[15]	-1	hSpCas9	negative selection	509954
4699287	4699310	20	+	26472758	Raji	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.8927019557007696	[310]	[133]	7	hSpCas9	negative selection	509955
4699448	4699471	20	-	26472758	Raji	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	0.07496205768122191	[269]	[65]	0	hSpCas9	negative selection	509956
4699476	4699499	20	+	26472758	Raji	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	0.4989620618284545	[185]	[60]	5	hSpCas9	negative selection	509957
4699495	4699518	20	+	26472758	Raji	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.35482108615637475	[309]	[91]	3	hSpCas9	negative selection	509958
4699822	4699845	20	-	26472758	Raji	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.35695568140083067	[322]	[95]	3	hSpCas9	negative selection	509959
4699859	4699882	20	+	26472758	Raji	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-0.9882687036900868	[264]	[30]	-6	hSpCas9	negative selection	509960
4699229	4699252	20	-	26472758	Raji	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.18899730092725142	[188]	[49]	1	hSpCas9	negative selection	509961
4699782	4699805	20	+	26472758	K562	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	0.11670028634482399	[719]	[658]	0	hSpCas9	negative selection	701070
4699261	4699284	20	-	26472758	K562	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	-0.4963384456621335	[380]	[227]	-3	hSpCas9	negative selection	701071
4699932	4699955	20	-	26472758	K562	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-1.5878538265954867	[145]	[40]	-7	hSpCas9	negative selection	701072
4699287	4699310	20	+	26472758	K562	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.4305909610901417	[362]	[412]	3	hSpCas9	negative selection	701073
4699448	4699471	20	-	26472758	K562	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	-0.2717048967267114	[531]	[371]	-2	hSpCas9	negative selection	701074
4699476	4699499	20	+	26472758	K562	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-2.5308749851588592	[533]	[77]	-8	hSpCas9	negative selection	701075
4699495	4699518	20	+	26472758	K562	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.8589255040016185	[434]	[665]	7	hSpCas9	negative selection	701076
4699822	4699845	20	-	26472758	K562	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.5617161562289013	[590]	[337]	-4	hSpCas9	negative selection	701077
4699859	4699882	20	+	26472758	K562	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-2.1665143732796603	[233]	[43]	-7	hSpCas9	negative selection	701078
4699229	4699252	20	-	26472758	K562	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.1995644918821864	[293]	[284]	1	hSpCas9	negative selection	701079
4699246	4699269	20	+	26627737	DLD1	viability	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	1.356141183622365	[113]	[84,126,66]	9	hSpCas9	negative selection	814973
4699291	4699314	20	+	26627737	DLD1	viability	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	-0.49780238996658255	[234]	[72,46,37]	-5	hSpCas9	negative selection	814974
4699783	4699806	20	+	26627737	DLD1	viability	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	-1.4774679930137644	[642]	[80,67,67]	-8	hSpCas9	negative selection	814975
4699826	4699849	20	+	26627737	DLD1	viability	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-2.031631670680106	[397]	[31,44,16]	-9	hSpCas9	negative selection	814976
4699858	4699881	20	+	26627737	DLD1	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.7597710461182853	[1160]	[178,357,125]	-6	hSpCas9	negative selection	814977
4699884	4699907	20	+	26627737	DLD1	viability	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	-2.279948221219184	[432]	[24,43,16]	-9	hSpCas9	negative selection	814978
4699246	4699269	20	+	26627737	GBM cells	viability after 5 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	0.407927522373543	[77]	[53,56]	6	hSpCas9	negative selection	897288
4699291	4699314	20	+	26627737	GBM cells	viability after 5 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	-0.11216962424333077	[391]	[150,237]	-2	hSpCas9	negative selection	897289
4699783	4699806	20	+	26627737	GBM cells	viability after 5 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.22295684194393672	[408]	[282,228]	3	hSpCas9	negative selection	897290
4699826	4699849	20	+	26627737	GBM cells	viability after 5 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	1.2547893016963858	[83]	[96,117]	9	hSpCas9	negative selection	897291
4699858	4699881	20	+	26627737	GBM cells	viability after 5 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.1703471641651504	[627]	[362,394]	2	hSpCas9	negative selection	897292
4699884	4699907	20	+	26627737	GBM cells	viability after 5 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.05091696833073561	[314]	[174,174]	0	hSpCas9	negative selection	897293
4699246	4699269	20	+	26627737	GBM cells	viability after 13 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	0.7196050090984606	[77]	[72,66]	8	hSpCas9	negative selection	979603
4699291	4699314	20	+	26627737	GBM cells	viability after 13 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	-0.3051089984569174	[391]	[191,155]	-4	hSpCas9	negative selection	979604
4699783	4699806	20	+	26627737	GBM cells	viability after 13 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.1922809224129015	[408]	[327,192]	2	hSpCas9	negative selection	979605
4699826	4699849	20	+	26627737	GBM cells	viability after 13 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	1.1933839742663015	[83]	[149,66]	9	hSpCas9	negative selection	979606
4699858	4699881	20	+	26627737	GBM cells	viability after 13 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.1268407858640741	[627]	[408,341]	1	hSpCas9	negative selection	979607
4699884	4699907	20	+	26627737	GBM cells	viability after 13 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	-0.15086952701113612	[314]	[175,135]	-2	hSpCas9	negative selection	979608
4699246	4699269	20	+	26627737	GBM cells	viability after 21 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	1.2782156347147722	[77]	[107,97]	9	hSpCas9	negative selection	1061918
4699291	4699314	20	+	26627737	GBM cells	viability after 21 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	-0.2884041559661936	[391]	[188,160]	-3	hSpCas9	negative selection	1061919
4699783	4699806	20	+	26627737	GBM cells	viability after 21 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.46996944237453986	[408]	[324,291]	5	hSpCas9	negative selection	1061920
4699826	4699849	20	+	26627737	GBM cells	viability after 21 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	1.7415270287840663	[83]	[161,143]	9	hSpCas9	negative selection	1061921
4699858	4699881	20	+	26627737	GBM cells	viability after 21 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.1734108985391407	[627]	[413,357]	1	hSpCas9	negative selection	1061922
4699884	4699907	20	+	26627737	GBM cells	viability after 21 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.1465716856711906	[314]	[190,187]	1	hSpCas9	negative selection	1061923
4699246	4699269	20	+	26627737	RPE1	viability after 9 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	1.170068923856917	[280]	[114,304]	7	hSpCas9	negative selection	1144233
4699291	4699314	20	+	26627737	RPE1	viability after 9 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.6310400810199016	[926]	[331,600]	4	hSpCas9	negative selection	1144234
4699783	4699806	20	+	26627737	RPE1	viability after 9 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.9296270254890011	[939]	[491,648]	6	hSpCas9	negative selection	1144235
4699826	4699849	20	+	26627737	RPE1	viability after 9 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-1.493976638813732	[1254]	[11,303]	-8	hSpCas9	negative selection	1144236
4699858	4699881	20	+	26627737	RPE1	viability after 9 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.33554023604018157	[1694]	[344,517]	-2	hSpCas9	negative selection	1144237
4699884	4699907	20	+	26627737	RPE1	viability after 9 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	1.1858662951094365	[729]	[515,524]	7	hSpCas9	negative selection	1144238
4699246	4699269	20	+	26627737	RPE1	viability after 12 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	0.4645009205463799	[280]	[92,115]	3	hSpCas9	negative selection	1226548
4699291	4699314	20	+	26627737	RPE1	viability after 12 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.48771366779227787	[926]	[356,340]	3	hSpCas9	negative selection	1226549
4699783	4699806	20	+	26627737	RPE1	viability after 12 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.7884404248615262	[939]	[476,392]	5	hSpCas9	negative selection	1226550
4699826	4699849	20	+	26627737	RPE1	viability after 12 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-0.53264346231744	[1254]	[150,319]	-4	hSpCas9	negative selection	1226551
4699858	4699881	20	+	26627737	RPE1	viability after 12 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.11064058845805436	[1694]	[430,411]	0	hSpCas9	negative selection	1226552
4699884	4699907	20	+	26627737	RPE1	viability after 12 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.783529851725581	[729]	[374,297]	5	hSpCas9	negative selection	1226553
4699246	4699269	20	+	26627737	RPE1	viability after 15 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	0.6541509454987686	[280]	[119,129]	4	hSpCas9	negative selection	1308863
4699291	4699314	20	+	26627737	RPE1	viability after 15 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.5117289926759736	[926]	[380,366]	3	hSpCas9	negative selection	1308864
4699783	4699806	20	+	26627737	RPE1	viability after 15 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.940020500661553	[939]	[388,626]	5	hSpCas9	negative selection	1308865
4699826	4699849	20	+	26627737	RPE1	viability after 15 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-0.3749420435658691	[1254]	[258,287]	-2	hSpCas9	negative selection	1308866
4699858	4699881	20	+	26627737	RPE1	viability after 15 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.270406661843557	[1694]	[503,649]	1	hSpCas9	negative selection	1308867
4699884	4699907	20	+	26627737	RPE1	viability after 15 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.9807005275527505	[729]	[462,353]	6	hSpCas9	negative selection	1308868
4699246	4699269	20	+	26627737	RPE1	viability after 18 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	0.8984740094084549	[280]	[78,207]	5	hSpCas9	negative selection	1391178
4699291	4699314	20	+	26627737	RPE1	viability after 18 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.529362896993343	[926]	[158,576]	3	hSpCas9	negative selection	1391179
4699783	4699806	20	+	26627737	RPE1	viability after 18 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.7731420149423696	[939]	[346,525]	5	hSpCas9	negative selection	1391180
4699826	4699849	20	+	26627737	RPE1	viability after 18 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-0.07034065241518872	[1254]	[207,444]	0	hSpCas9	negative selection	1391181
4699858	4699881	20	+	26627737	RPE1	viability after 18 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.5090985952870578	[1694]	[318,323]	-3	hSpCas9	negative selection	1391182
4699884	4699907	20	+	26627737	RPE1	viability after 18 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.6415686301686288	[729]	[316,296]	4	hSpCas9	negative selection	1391183
4699246	4699269	20	+	26627737	HeLa	viability after 8 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	1.7287619003045214	[61]	[143,116,23]	9	hSpCas9	negative selection	1473493
4699291	4699314	20	+	26627737	HeLa	viability after 8 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	-0.7269730940148484	[441]	[57,60,209]	-6	hSpCas9	negative selection	1473494
4699783	4699806	20	+	26627737	HeLa	viability after 8 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.12107355610617743	[766]	[372,323,391]	1	hSpCas9	negative selection	1473495
4699826	4699849	20	+	26627737	HeLa	viability after 8 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	0.3570287320225555	[296]	[166,165,163]	3	hSpCas9	negative selection	1473496
4699858	4699881	20	+	26627737	HeLa	viability after 8 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.8214990751151934	[632]	[519,510,439]	6	hSpCas9	negative selection	1473497
4699884	4699907	20	+	26627737	HeLa	viability after 8 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.7123137475320012	[289]	[261,201,170]	6	hSpCas9	negative selection	1473498
4699246	4699269	20	+	26627737	HeLa	viability after 12 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	2.0413219264372584	[61]	[103,89,123]	9	hSpCas9	negative selection	1555808
4699291	4699314	20	+	26627737	HeLa	viability after 12 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.1772841000649071	[441]	[99,239,272]	1	hSpCas9	negative selection	1555809
4699783	4699806	20	+	26627737	HeLa	viability after 12 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	-0.5977869464847452	[766]	[230,227,167]	-5	hSpCas9	negative selection	1555810
4699826	4699849	20	+	26627737	HeLa	viability after 12 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-1.1170344668408319	[296]	[39,96,27]	-8	hSpCas9	negative selection	1555811
4699858	4699881	20	+	26627737	HeLa	viability after 12 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.4407080550186715	[632]	[395,282,394]	4	hSpCas9	negative selection	1555812
4699884	4699907	20	+	26627737	HeLa	viability after 12 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.6640373654116742	[289]	[348,107,125]	5	hSpCas9	negative selection	1555813
4699246	4699269	20	+	26627737	HeLa	viability after 15 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	1.3307726159602864	[61]	[11,80,100]	8	hSpCas9	negative selection	1638123
4699291	4699314	20	+	26627737	HeLa	viability after 15 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.44170508871251235	[441]	[75,370,291]	3	hSpCas9	negative selection	1638124
4699783	4699806	20	+	26627737	HeLa	viability after 15 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.4163721248395452	[766]	[356,596,286]	3	hSpCas9	negative selection	1638125
4699826	4699849	20	+	26627737	HeLa	viability after 15 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-0.560043013903389	[296]	[78,97,67]	-5	hSpCas9	negative selection	1638126
4699858	4699881	20	+	26627737	HeLa	viability after 15 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.9431979003515907	[632]	[515,573,387]	7	hSpCas9	negative selection	1638127
4699884	4699907	20	+	26627737	HeLa	viability after 15 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.206402666126481	[289]	[125,143,138]	1	hSpCas9	negative selection	1638128
4699246	4699269	20	+	26627737	HeLa	viability after 18 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	1.3664528115135375	[61]	[7,70,100]	8	hSpCas9	negative selection	1720438
4699291	4699314	20	+	26627737	HeLa	viability after 18 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.4333305977992855	[441]	[45,309,291]	3	hSpCas9	negative selection	1720439
4699783	4699806	20	+	26627737	HeLa	viability after 18 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.43616904617796537	[766]	[250,493,286]	3	hSpCas9	negative selection	1720440
4699826	4699849	20	+	26627737	HeLa	viability after 18 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-0.685870019141563	[296]	[46,71,67]	-6	hSpCas9	negative selection	1720441
4699858	4699881	20	+	26627737	HeLa	viability after 18 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.9659956577801287	[632]	[356,480,387]	7	hSpCas9	negative selection	1720442
4699884	4699907	20	+	26627737	HeLa	viability after 18 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.16480655949876016	[289]	[77,117,138]	1	hSpCas9	negative selection	1720443
4699246	4699269	20	+	26627737	HCT116	viability after 6 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	2.0998420958361628	[20]	[37,0]	8	hSpCas9	negative selection	1802753
4699291	4699314	20	+	26627737	HCT116	viability after 6 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	-0.3112799079051027	[816]	[234,30]	-2	hSpCas9	negative selection	1802754
4699783	4699806	20	+	26627737	HCT116	viability after 6 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	1.7866328552393238	[791]	[785,232]	8	hSpCas9	negative selection	1802755
4699826	4699849	20	+	26627737	HCT116	viability after 6 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-0.29560063984974394	[513]	[128,30]	-2	hSpCas9	negative selection	1802756
4699858	4699881	20	+	26627737	HCT116	viability after 6 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.09989104106013635	[1914]	[379,290]	0	hSpCas9	negative selection	1802757
4699884	4699907	20	+	26627737	HCT116	viability after 6 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	-1.8372745003101931	[692]	[34,27]	-8	hSpCas9	negative selection	1802758
4699246	4699269	20	+	26627737	HCT116	viability after 8 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	0.08296063222936523	[118]	[82,88,36]	1	hSpCas9	negative selection	1885068
4699291	4699314	20	+	26627737	HCT116	viability after 8 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.39268673045782165	[297]	[167,189,286]	4	hSpCas9	negative selection	1885069
4699783	4699806	20	+	26627737	HCT116	viability after 8 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	1.116188200309948	[260]	[270,223,437]	8	hSpCas9	negative selection	1885070
4699826	4699849	20	+	26627737	HCT116	viability after 8 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	0.34574773063735575	[129]	[144,32,95]	4	hSpCas9	negative selection	1885071
4699858	4699881	20	+	26627737	HCT116	viability after 8 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.20502279082462893	[946]	[490,351,514]	-2	hSpCas9	negative selection	1885072
4699884	4699907	20	+	26627737	HCT116	viability after 8 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.2362988366355766	[402]	[325,288,171]	2	hSpCas9	negative selection	1885073
4699246	4699269	20	+	26627737	HCT116	viability after 9 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	3.161459099521614	[20]	[100,9]	9	hSpCas9	negative selection	1967383
4699291	4699314	20	+	26627737	HCT116	viability after 9 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.36790407920186924	[816]	[452,145]	2	hSpCas9	negative selection	1967384
4699783	4699806	20	+	26627737	HCT116	viability after 9 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.5175626766644997	[791]	[495,149]	4	hSpCas9	negative selection	1967385
4699826	4699849	20	+	26627737	HCT116	viability after 9 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-1.4859248937252016	[513]	[48,48]	-8	hSpCas9	negative selection	1967386
4699858	4699881	20	+	26627737	HCT116	viability after 9 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.005132122035971243	[1914]	[606,438]	0	hSpCas9	negative selection	1967387
4699884	4699907	20	+	26627737	HCT116	viability after 9 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.3847764321236583	[692]	[335,166]	3	hSpCas9	negative selection	1967388
4699246	4699269	20	+	26627737	HCT116	viability after 12 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	0.41861578391111975	[118]	[77,113,59]	4	hSpCas9	negative selection	2049698
4699291	4699314	20	+	26627737	HCT116	viability after 12 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	-0.08631965345490622	[297]	[62,272,116]	-1	hSpCas9	negative selection	2049699
4699783	4699806	20	+	26627737	HCT116	viability after 12 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	1.3084569388801792	[260]	[276,270,474]	8	hSpCas9	negative selection	2049700
4699826	4699849	20	+	26627737	HCT116	viability after 12 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	0.926724008321357	[129]	[219,59,99]	7	hSpCas9	negative selection	2049701
4699858	4699881	20	+	26627737	HCT116	viability after 12 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.03223664233121348	[946]	[502,414,606]	0	hSpCas9	negative selection	2049702
4699884	4699907	20	+	26627737	HCT116	viability after 12 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.05346053062206502	[402]	[225,227,204]	0	hSpCas9	negative selection	2049703
4699246	4699269	20	+	26627737	HCT116	viability after 15 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	-0.3488637853301424	[118]	[90,59,14]	-4	hSpCas9	negative selection	2132013
4699291	4699314	20	+	26627737	HCT116	viability after 15 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.4877252466392212	[297]	[179,239,291]	4	hSpCas9	negative selection	2132014
4699783	4699806	20	+	26627737	HCT116	viability after 15 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.707898741269191	[260]	[337,175,231]	6	hSpCas9	negative selection	2132015
4699826	4699849	20	+	26627737	HCT116	viability after 15 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	0.439124567882914	[129]	[158,75,75]	4	hSpCas9	negative selection	2132016
4699858	4699881	20	+	26627737	HCT116	viability after 15 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.2703228315226607	[946]	[521,434,404]	-3	hSpCas9	negative selection	2132017
4699884	4699907	20	+	26627737	HCT116	viability after 15 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.18049853737405597	[402]	[347,245,203]	1	hSpCas9	negative selection	2132018
4699246	4699269	20	+	26627737	HCT116	viability after 18 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	0.4982110840535985	[118]	[99,45,100]	4	hSpCas9	negative selection	2214328
4699291	4699314	20	+	26627737	HCT116	viability after 18 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	-0.10205403705650218	[297]	[99,196,99]	-1	hSpCas9	negative selection	2214329
4699783	4699806	20	+	26627737	HCT116	viability after 18 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.6914514193958975	[260]	[104,246,258]	5	hSpCas9	negative selection	2214330
4699826	4699849	20	+	26627737	HCT116	viability after 18 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	0.7792488969895426	[129]	[105,87,131]	6	hSpCas9	negative selection	2214331
4699858	4699881	20	+	26627737	HCT116	viability after 18 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.36114661944716864	[946]	[524,623,613]	3	hSpCas9	negative selection	2214332
4699884	4699907	20	+	26627737	HCT116	viability after 18 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.07903348163252077	[402]	[313,181,118]	0	hSpCas9	negative selection	2214333
4699212	4699235	20	+	24336569	HL60	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	1.0083083729697822	[513]	[2187]	7	hSpCas9	negative selection	2286662
4699219	4699242	20	+	24336569	HL60	viability	TTATGGCGAACCTTGGCTGCTGG	PRNP	ENSG00000171867	-0.2698659548039529	[387]	[680]	-2	hSpCas9	negative selection	2286663
4699226	4699249	20	+	24336569	HL60	viability	GAACCTTGGCTGCTGGATGCTGG	PRNP	ENSG00000171867	-2.0547467622531173	[427]	[217]	-9	hSpCas9	negative selection	2286664
4699300	4699323	20	+	24336569	HL60	viability	AGCCTGGAGGATGGAACACTGGG	PRNP	ENSG00000171867	-0.473890164172864	[1244]	[1896]	-4	hSpCas9	negative selection	2286665
4699349	4699372	20	-	24336569	HL60	viability	GTGGGTAGCGGTTGCCTCCAGGG	PRNP	ENSG00000171867	0.8211090513585213	[646]	[2418]	6	hSpCas9	negative selection	2286666
4699355	4699378	20	+	24336569	HL60	viability	AGGCAACCGCTACCCACCTCAGG	PRNP	ENSG00000171867	0.6325783492571897	[405]	[1331]	5	hSpCas9	negative selection	2286667
4699361	4699384	20	-	24336569	HL60	viability	CACCGCCCTGAGGTGGGTAGCGG	PRNP	ENSG00000171867	0.020810934810057136	[911]	[1957]	0	hSpCas9	negative selection	2286668
4699367	4699390	20	-	24336569	HL60	viability	AGCCACCACCGCCCTGAGGTGGG	PRNP	ENSG00000171867	-0.7024693512755836	[688]	[895]	-6	hSpCas9	negative selection	2286669
4699495	4699518	20	+	24336569	HL60	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	-0.46534066842127947	[915]	[1403]	-4	hSpCas9	negative selection	2286670
4699504	4699527	20	-	24336569	HL60	viability	CGGCTTGTTCCACTGACTGTGGG	PRNP	ENSG00000171867	-0.9742105139171449	[608]	[655]	-7	hSpCas9	negative selection	2286671
4699212	4699235	20	+	24336569	KBM7	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	0.17632373313068772	[596]	[1839]	1	hSpCas9	negative selection	2353839
4699219	4699242	20	+	24336569	KBM7	viability	TTATGGCGAACCTTGGCTGCTGG	PRNP	ENSG00000171867	0.367804099264656	[255]	[900]	3	hSpCas9	negative selection	2353840
4699226	4699249	20	+	24336569	KBM7	viability	GAACCTTGGCTGCTGGATGCTGG	PRNP	ENSG00000171867	-0.2752151496551529	[196]	[443]	-2	hSpCas9	negative selection	2353841
4699300	4699323	20	+	24336569	KBM7	viability	AGCCTGGAGGATGGAACACTGGG	PRNP	ENSG00000171867	-0.15598564850989405	[941]	[2305]	-1	hSpCas9	negative selection	2353842
4699349	4699372	20	-	24336569	KBM7	viability	GTGGGTAGCGGTTGCCTCCAGGG	PRNP	ENSG00000171867	-0.29186805432627094	[679]	[1514]	-2	hSpCas9	negative selection	2353843
4699355	4699378	20	+	24336569	KBM7	viability	AGGCAACCGCTACCCACCTCAGG	PRNP	ENSG00000171867	1.319081628997756	[338]	[2306]	9	hSpCas9	negative selection	2353844
4699361	4699384	20	-	24336569	KBM7	viability	CACCGCCCTGAGGTGGGTAGCGG	PRNP	ENSG00000171867	0.7855179251308075	[632]	[2975]	7	hSpCas9	negative selection	2353845
4699367	4699390	20	-	24336569	KBM7	viability	AGCCACCACCGCCCTGAGGTGGG	PRNP	ENSG00000171867	0.12313114924506796	[372]	[1107]	1	hSpCas9	negative selection	2353846
4699495	4699518	20	+	24336569	KBM7	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.1009991536780844	[347]	[1017]	0	hSpCas9	negative selection	2353847
4699504	4699527	20	-	24336569	KBM7	viability	CGGCTTGTTCCACTGACTGTGGG	PRNP	ENSG00000171867	0.5433962386531349	[440]	[1752]	5	hSpCas9	negative selection	2353848
4686367	4686390	20	-	25494202	A375	resistance to PLX-4720 (puromycin)	CTCGCGGGCGGAGGTCGGCGCGG	PRNP	ENSG00000171867	0.05771928461348422	[186,7]	[37,3]	0	dCas9-VP64	positive selection	2393152
4686344	4686367	20	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGACCAATTGCCGCGCGGCCCGG	PRNP	ENSG00000171867	0.7845341070491215	[221,17]	[82,2]	3	dCas9-VP64	positive selection	2393153
4686326	4686349	20	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGGGGCACAGAGTGTGCGCCGGG	PRNP	ENSG00000171867	3.7632997451039305	[21,5]	[78,3]	9	dCas9-VP64	positive selection	2393154
4686403	4686426	20	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGGAGGGACGCGGGGCGGGGAAG	PRNP	ENSG00000171867	0.5865672333456198	[9,0]	[1,0]	2	dCas9-VP64	positive selection	2459716
4686367	4686390	20	-	25494202	A375	resistance to PLX-4720 (zeocin)	CTCGCGGGCGGAGGTCGGCGCGG	PRNP	ENSG00000171867	0.39997106548715844	[53,165]	[11,79]	3	dCas9-VP64	positive selection	2488407
4686344	4686367	20	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGACCAATTGCCGCGCGGCCCGG	PRNP	ENSG00000171867	2.0601995664335164	[29,12]	[51,8]	8	dCas9-VP64	positive selection	2488408
4686326	4686349	20	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGGGGCACAGAGTGTGCGCCGGG	PRNP	ENSG00000171867	0.49686737385268204	[85,30]	[41,12]	4	dCas9-VP64	positive selection	2488409
4686403	4686426	20	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGGAGGGACGCGGGGCGGGGAAG	PRNP	ENSG00000171867	-0.2526986247951699	[4,5]	[0,0]	-2	dCas9-VP64	positive selection	2554971
4699360	4699383	20	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AACCGCTACCCACCTCAGGGCGG	PRNP	ENSG00000171867	1.011935372367417	[1,1]	[3,3]	9	hSpCas9	positive selection	3013780
4699288	4699311	20	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.05971354312721064	[3,4]	[4,2]	1	hSpCas9	positive selection	3013781
4699213	4699236	20	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	0.08989862013155292	[3,4]	[3,3]	1	hSpCas9	positive selection	3013782
4699470	4699493	20	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGACCCCAGCCACCACCATGAGG	PRNP	ENSG00000171867	0.5694431991024398	[2,3]	[3,4]	9	hSpCas9	positive selection	3013783
4699360	4699383	20	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AACCGCTACCCACCTCAGGGCGG	PRNP	ENSG00000171867	0.2633751584006324	[1,1]	[0,1]	4	hSpCas9	positive selection	3081638
4699288	4699311	20	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.520863681272346	[3,3]	[4,3]	8	hSpCas9	positive selection	3081639
4699213	4699236	20	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	0.46482774386328624	[3,3]	[4,3]	7	hSpCas9	positive selection	3081640
4699470	4699493	20	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGACCCCAGCCACCACCATGAGG	PRNP	ENSG00000171867	0.5186077543326537	[2,2]	[1,2]	8	hSpCas9	positive selection	3081641
4699868	4699891	20	-	27383988	293T	resistance to West Nile virus (flavivirus)	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	-1.9521271541831147	[591,591]	[0,0]	-9	hSpCas9	positive selection	3387579
4699858	4699881	20	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.17730201619088934	[172,172]	[0,0]	-1	hSpCas9	positive selection	3387580
4699822	4699845	20	-	27383988	293T	resistance to West Nile virus (flavivirus)	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.5522698652343732	[312,312]	[2,2]	3	hSpCas9	positive selection	3387581
4699359	4699382	20	+	26780180	HT29	viability (Avana library 4 designs)	AACCGCTACCCACCTCAGGGCGG	PRNP	ENSG00000171867	1.10834008804911	[]	[]	4	hSpCas9	negative selection	3451975
4699287	4699310	20	+	26780180	HT29	viability (Avana library 4 designs)	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	-0.0507619759999153	[]	[]	-1	hSpCas9	negative selection	3451976
4699212	4699235	20	+	26780180	HT29	viability (Avana library 4 designs)	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	0.0626914218718517	[]	[]	0	hSpCas9	negative selection	3451977
4699470	4699493	20	-	26780180	HT29	viability (Avana library 4 designs)	TGACCCCAGCCACCACCATGAGG	PRNP	ENSG00000171867	0.568828961628467	[]	[]	2	hSpCas9	negative selection	3451978
4699287	4699310	20	+	26780180	A375	viability (Avana lentiCRISPRv2)	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.896916235478454	[]	[]	1	hSpCas9	negative selection	3548123
4699470	4699493	20	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGACCCCAGCCACCACCATGAGG	PRNP	ENSG00000171867	2.77416128409741	[]	[]	4	hSpCas9	negative selection	3548124
4699212	4699235	20	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.152983718805163	[]	[]	0	hSpCas9	negative selection	3548125
4699359	4699382	20	+	26780180	A375	viability (Avana lentiCRISPRv2)	AACCGCTACCCACCTCAGGGCGG	PRNP	ENSG00000171867	3.65144012130881	[]	[]	6	hSpCas9	negative selection	3548126
4699446	4699469	20	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGTCCCCAGCCACCACCATGGGG	PRNP	ENSG00000171867	1.40780269293264	[]	[]	2	hSpCas9	negative selection	3548127
4699318	4699341	20	+	26780180	A375	viability (Avana lentiCRISPRv2)	CTGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	6.06005873445813	[]	[]	9	hSpCas9	negative selection	3548128
4699287	4699310	20	+	26780180	A375	viability (Avana lentiGuide)	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.705257346781252	[]	[]	0	hSpCas9	negative selection	3656782
4699470	4699493	20	-	26780180	A375	viability (Avana lentiGuide)	TGACCCCAGCCACCACCATGAGG	PRNP	ENSG00000171867	1.18048908208807	[]	[]	1	hSpCas9	negative selection	3656783
4699212	4699235	20	+	26780180	A375	viability (Avana lentiGuide)	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	0.248277752991339	[]	[]	0	hSpCas9	negative selection	3656784
4699359	4699382	20	+	26780180	A375	viability (Avana lentiGuide)	AACCGCTACCCACCTCAGGGCGG	PRNP	ENSG00000171867	6.30229001117801	[]	[]	5	hSpCas9	negative selection	3656785
4699446	4699469	20	-	26780180	A375	viability (Avana lentiGuide)	TGTCCCCAGCCACCACCATGGGG	PRNP	ENSG00000171867	1.91589357208122	[]	[]	2	hSpCas9	negative selection	3656786
4699318	4699341	20	+	26780180	A375	viability (Avana lentiGuide)	CTGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	-0.270591567279664	[]	[]	0	hSpCas9	negative selection	3656787
4699287	4699310	20	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	-0.11286242343226632	[4]	[4,4]	-2	hSpCas9	positive selection	3765389
4699470	4699493	20	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGACCCCAGCCACCACCATGAGG	PRNP	ENSG00000171867	0.115550325630738	[3]	[2,5]	3	hSpCas9	positive selection	3765390
4699212	4699235	20	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	0.1160571617518788	[4]	[5,4]	3	hSpCas9	positive selection	3765391
4699359	4699382	20	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AACCGCTACCCACCTCAGGGCGG	PRNP	ENSG00000171867	0.4168398259414494	[3]	[5,5]	9	hSpCas9	positive selection	3765392
4699446	4699469	20	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGTCCCCAGCCACCACCATGGGG	PRNP	ENSG00000171867	0.1516859158807304	[5]	[6,5]	4	hSpCas9	positive selection	3765393
4699318	4699341	20	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	0.43147469106376196	[4]	[6,5]	9	hSpCas9	positive selection	3765394
4699287	4699310	20	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.1306867614522881	[5]	[5,5]	3	hSpCas9	positive selection	3873996
4699470	4699493	20	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGACCCCAGCCACCACCATGAGG	PRNP	ENSG00000171867	-0.36301960431457164	[4]	[2,2]	-5	hSpCas9	positive selection	3873997
4699212	4699235	20	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.026780628765256907	[5]	[3,5]	0	hSpCas9	positive selection	3873998
4699359	4699382	20	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AACCGCTACCCACCTCAGGGCGG	PRNP	ENSG00000171867	-1.0431499419115615	[3]	[1,0]	-8	hSpCas9	positive selection	3873999
4699446	4699469	20	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGTCCCCAGCCACCACCATGGGG	PRNP	ENSG00000171867	-0.025173924224814376	[6]	[4,5]	0	hSpCas9	positive selection	3874000
4699318	4699341	20	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	0.03116497052228051	[4]	[4,3]	0	hSpCas9	positive selection	3874001
4699690	4699713	20	+	26780180	A375	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	2.27429110639077	[]	[]	9	hSpCas9	negative selection	3984467
4699868	4699891	20	-	26780180	A375	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	1.2994213376875	[]	[]	7	hSpCas9	negative selection	3984468
4699817	4699840	20	+	26780180	A375	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.702513939900716	[]	[]	2	hSpCas9	negative selection	3984469
4699212	4699235	20	+	26780180	A375	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	1.12140878224833	[]	[]	5	hSpCas9	negative selection	3984470
4699822	4699845	20	-	26780180	A375	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.982782434496354	[]	[]	4	hSpCas9	negative selection	3984471
4699858	4699881	20	+	26780180	A375	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	1.18433535608808	[]	[]	6	hSpCas9	negative selection	3984472
4699690	4699713	20	+	26780180	HT29	viability (GeCKOv2 library)	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	2.32895121517796	[]	[]	9	hSpCas9	negative selection	4092433
4699868	4699891	20	-	26780180	HT29	viability (GeCKOv2 library)	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.284706886320414	[]	[]	0	hSpCas9	negative selection	4092434
4699817	4699840	20	+	26780180	HT29	viability (GeCKOv2 library)	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.419180360429719	[]	[]	1	hSpCas9	negative selection	4092435
4699212	4699235	20	+	26780180	HT29	viability (GeCKOv2 library)	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	1.22780510521279	[]	[]	6	hSpCas9	negative selection	4092436
4699822	4699845	20	-	26780180	HT29	viability (GeCKOv2 library)	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	1.10194096389324	[]	[]	5	hSpCas9	negative selection	4092437
4699858	4699881	20	+	26780180	HT29	viability (GeCKOv2 library)	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	1.20966441675855	[]	[]	6	hSpCas9	negative selection	4092438
4699817	4699840	20	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.15455103242808896	[2]	[2,0]	-3	hSpCas9	positive selection	4292278
4699690	4699713	20	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	-0.8965524610889105	[3]	[1,0]	-9	hSpCas9	positive selection	4292279
4699212	4699235	20	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.3907881869671671	[2]	[2,0]	-7	hSpCas9	positive selection	4292280
4699868	4699891	20	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.25225494598202597	[4]	[4,3]	5	hSpCas9	positive selection	4356537
4699858	4699881	20	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.07207386944482672	[3]	[2,1]	1	hSpCas9	positive selection	4356538
4699822	4699845	20	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.24918614081452722	[3]	[2,1]	-5	hSpCas9	positive selection	4356539
4699319	4699341	20	+	27760321	OCIAML3	viability	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	0.5922631567894723	[672,540]	[636,808]	7	hSpCas9	negative selection	4430753
4699350	4699372	20	-	27760321	OCIAML3	viability	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	0.2825129806417733	[754,693]	[705,666]	3	hSpCas9	negative selection	4430754
4699368	4699390	20	-	27760321	OCIAML3	viability	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	0.23863351604175276	[1103,834]	[790,1012]	2	hSpCas9	negative selection	4430755
4699629	4699651	20	-	27760321	OCIAML3	viability	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	0.5950275911382512	[311,237]	[294,357]	7	hSpCas9	negative selection	4430756
4699697	4699719	20	-	27760321	OCIAML3	viability	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	0.35100966694332847	[556,449]	[413,610]	4	hSpCas9	negative selection	4430757
4699319	4699341	20	+	27760321	OCIAML2	viability	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	0.8075791236068477	[672,540]	[807,915]	9	hSpCas9	negative selection	4514216
4699350	4699372	20	-	27760321	OCIAML2	viability	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	0.20309039704666887	[754,693]	[611,756]	2	hSpCas9	negative selection	4514217
4699368	4699390	20	-	27760321	OCIAML2	viability	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	-0.17174988137502412	[1103,834]	[599,809]	-2	hSpCas9	negative selection	4514218
4699629	4699651	20	-	27760321	OCIAML2	viability	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	0.4553594102565116	[311,237]	[268,346]	6	hSpCas9	negative selection	4514219
4699697	4699719	20	-	27760321	OCIAML2	viability	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	0.2575654590476404	[556,449]	[422,564]	3	hSpCas9	negative selection	4514220
4699319	4699341	20	+	27760321	MV411	viability	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	0.20080704407027816	[672,540]	[436,488]	1	hSpCas9	negative selection	4597679
4699350	4699372	20	-	27760321	MV411	viability	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	0.4284363610881775	[754,693]	[524,820]	3	hSpCas9	negative selection	4597680
4699368	4699390	20	-	27760321	MV411	viability	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	-0.7174515955492065	[1103,834]	[70,858]	-5	hSpCas9	negative selection	4597681
4699629	4699651	20	-	27760321	MV411	viability	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	-0.17207241458333722	[311,237]	[182,124]	-1	hSpCas9	negative selection	4597682
4699697	4699719	20	-	27760321	MV411	viability	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	0.30708136168972555	[556,449]	[453,340]	2	hSpCas9	negative selection	4597683
4699319	4699341	20	+	27760321	HL60	viability	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	0.05644400542152661	[672,540]	[403,627]	0	hSpCas9	negative selection	4681142
4699350	4699372	20	-	27760321	HL60	viability	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	0.2527108014451611	[754,693]	[754,651]	3	hSpCas9	negative selection	4681143
4699368	4699390	20	-	27760321	HL60	viability	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	0.12495379495587589	[1103,834]	[1108,588]	1	hSpCas9	negative selection	4681144
4699629	4699651	20	-	27760321	HL60	viability	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	0.7861210404085726	[311,237]	[346,423]	8	hSpCas9	negative selection	4681145
4699697	4699719	20	-	27760321	HL60	viability	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	0.21286367563888117	[556,449]	[410,540]	2	hSpCas9	negative selection	4681146
4699319	4699341	20	+	27760321	HT1080	viability	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	0.8165648774055901	[540,421]	[354,318]	4	hSpCas9	negative selection	4764605
4699350	4699372	20	-	27760321	HT1080	viability	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	-1.806258626257891	[693,541]	[4,141]	-6	hSpCas9	negative selection	4764606
4699368	4699390	20	-	27760321	HT1080	viability	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	-1.9829371646687504	[834,651]	[83,64]	-6	hSpCas9	negative selection	4764607
4699629	4699651	20	-	27760321	HT1080	viability	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	0.16071523508288288	[237,185]	[60,130]	0	hSpCas9	negative selection	4764608
4699697	4699719	20	-	27760321	HT1080	viability	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	1.8767712147152695	[449,350]	[794,356]	8	hSpCas9	negative selection	4764609
4699319	4699341	20	+	27760321	HT29	viability after 7 days	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	0.43547248037881425	[540,421]	[1227,626,714]	6	hSpCas9	negative selection	4848068
4699350	4699372	20	-	27760321	HT29	viability after 7 days	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	0.38607875811326786	[693,541]	[1091,1105,926]	6	hSpCas9	negative selection	4848069
4699368	4699390	20	-	27760321	HT29	viability after 7 days	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	0.7829321152044459	[834,651]	[1575,1595,1746]	9	hSpCas9	negative selection	4848070
4699629	4699651	20	-	27760321	HT29	viability after 7 days	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	0.1767361010404893	[237,185]	[257,230,423]	2	hSpCas9	negative selection	4848071
4699697	4699719	20	-	27760321	HT29	viability after 7 days	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	0.5513107033269651	[449,350]	[995,768,538]	8	hSpCas9	negative selection	4848072
4699319	4699341	20	+	27760321	HT29	viability after 25 days	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	1.0623737609508486	[540,421]	[1028,957,1502]	9	hSpCas9	negative selection	4931531
4699350	4699372	20	-	27760321	HT29	viability after 25 days	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	0.2876461425100427	[693,541]	[679,955,971]	3	hSpCas9	negative selection	4931532
4699368	4699390	20	-	27760321	HT29	viability after 25 days	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	0.7014038994135601	[834,651]	[1317,1352,1486]	7	hSpCas9	negative selection	4931533
4699629	4699651	20	-	27760321	HT29	viability after 25 days	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	0.6519371702750412	[237,185]	[287,421,443]	7	hSpCas9	negative selection	4931534
4699697	4699719	20	-	27760321	HT29	viability after 25 days	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	0.7950889958660275	[449,350]	[597,739,1085]	8	hSpCas9	negative selection	4931535
4699319	4699341	20	+	27760321	HT29	viability after 22 days	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	0.9373997347479616	[540,421]	[929,1051,1220]	9	hSpCas9	negative selection	5014994
4699350	4699372	20	-	27760321	HT29	viability after 22 days	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	0.25453326994269543	[693,541]	[615,919,1028]	2	hSpCas9	negative selection	5014995
4699368	4699390	20	-	27760321	HT29	viability after 22 days	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	0.7536324662459928	[834,651]	[1815,1041,1479]	8	hSpCas9	negative selection	5014996
4699629	4699651	20	-	27760321	HT29	viability after 22 days	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	0.5659285338416014	[237,185]	[405,456,222]	6	hSpCas9	negative selection	5014997
4699697	4699719	20	-	27760321	HT29	viability after 22 days	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	1.0210091439276765	[449,350]	[855,1009,954]	9	hSpCas9	negative selection	5014998
4699319	4699341	20	+	27760321	HT29	viability after 19 days	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	0.6827164853419122	[540,421]	[1103,494,1067]	7	hSpCas9	negative selection	5098457
4699350	4699372	20	-	27760321	HT29	viability after 19 days	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	0.48565095193599483	[693,541]	[807,1086,1051]	5	hSpCas9	negative selection	5098458
4699368	4699390	20	-	27760321	HT29	viability after 19 days	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	0.5144882688925534	[834,651]	[1563,1118,1004]	5	hSpCas9	negative selection	5098459
4699629	4699651	20	-	27760321	HT29	viability after 19 days	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	0.9098076322212832	[237,185]	[467,478,421]	8	hSpCas9	negative selection	5098460
4699697	4699719	20	-	27760321	HT29	viability after 19 days	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	0.9848461646404707	[449,350]	[824,1104,784]	8	hSpCas9	negative selection	5098461
4699319	4699341	20	+	27760321	HT29	viability after 16 days	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	1.0917210442526075	[540,421]	[1165,1292,982]	9	hSpCas9	negative selection	5181920
4699350	4699372	20	-	27760321	HT29	viability after 16 days	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	0.49519490684835676	[693,541]	[1047,1073,805]	5	hSpCas9	negative selection	5181921
4699368	4699390	20	-	27760321	HT29	viability after 16 days	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	0.7530157126472787	[834,651]	[1252,1076,1869]	8	hSpCas9	negative selection	5181922
4699629	4699651	20	-	27760321	HT29	viability after 16 days	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	0.7152704561668933	[237,185]	[450,315,408]	8	hSpCas9	negative selection	5181923
4699697	4699719	20	-	27760321	HT29	viability after 16 days	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	0.9972388301356394	[449,350]	[501,933,1208]	9	hSpCas9	negative selection	5181924
4699319	4699341	20	+	27760321	HT29	viability after 13 days	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	1.074413526518017	[540,421]	[1360,1021,1146]	9	hSpCas9	negative selection	5265383
4699350	4699372	20	-	27760321	HT29	viability after 13 days	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	0.3771141583419264	[693,541]	[1030,1033,739]	5	hSpCas9	negative selection	5265384
4699368	4699390	20	-	27760321	HT29	viability after 13 days	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	0.7304652422687605	[834,651]	[1252,1360,1664]	8	hSpCas9	negative selection	5265385
4699629	4699651	20	-	27760321	HT29	viability after 13 days	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	0.6360161664470176	[237,185]	[335,449,361]	8	hSpCas9	negative selection	5265386
4699697	4699719	20	-	27760321	HT29	viability after 13 days	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	1.0715918276566248	[449,350]	[1381,785,772]	9	hSpCas9	negative selection	5265387
4699319	4699341	20	+	27760321	HT29	viability after 10 days	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	0.9402111252404998	[540,421]	[1261,997,1194]	9	hSpCas9	negative selection	5348846
4699350	4699372	20	-	27760321	HT29	viability after 10 days	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	0.36891167921387824	[693,541]	[873,1085,1030]	5	hSpCas9	negative selection	5348847
4699368	4699390	20	-	27760321	HT29	viability after 10 days	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	0.790592657451318	[834,651]	[1533,1293,1971]	9	hSpCas9	negative selection	5348848
4699629	4699651	20	-	27760321	HT29	viability after 10 days	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	0.48725564433082724	[237,185]	[439,276,392]	6	hSpCas9	negative selection	5348849
4699697	4699719	20	-	27760321	HT29	viability after 10 days	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	0.32416737042291566	[449,350]	[752,610,515]	4	hSpCas9	negative selection	5348850
4699319	4699341	20	+	27760321	MOLM13	viability	TGGGGGCAGCCGATACCCGGGG	PRNP	ENSG00000171867	1.3622450543407425	[672,540]	[1070,708]	8	hSpCas9	negative selection	5432309
4699350	4699372	20	-	27760321	MOLM13	viability	GTGGGTAGCGGTTGCCTCCAGG	PRNP	ENSG00000171867	-0.8860782340881028	[754,693]	[373,90]	-5	hSpCas9	negative selection	5432310
4699368	4699390	20	-	27760321	MOLM13	viability	AGCCACCACCGCCCTGAGGTGG	PRNP	ENSG00000171867	0.5092472939956985	[1103,834]	[163,1289]	3	hSpCas9	negative selection	5432311
4699629	4699651	20	-	27760321	MOLM13	viability	CACTGCCGAAATGTATGATGGG	PRNP	ENSG00000171867	0.27563120791271156	[311,237]	[120,241]	1	hSpCas9	negative selection	5432312
4699697	4699719	20	-	27760321	MOLM13	viability	CATGGGCCTGTAGTACACTTGG	PRNP	ENSG00000171867	0.7771264409160614	[556,449]	[918,113]	5	hSpCas9	negative selection	5432313
4686454	4686477	20	+	27661255	K562	viability	GAGCCAGTCGCTGACAGCCGCGG	PRNP	ENSG00000171867	-0.009049598553843963	[526,699]	[463,501]	0	dCas9-KRAB	negative selection	5504292
4686508	4686531	20	+	27661255	K562	viability	GGCAGGTAAACGCCCGGGGTGGG	PRNP	ENSG00000171867	-1.3178235949767674	[636,789]	[237,218]	-9	dCas9-KRAB	negative selection	5504293
4686870	4686893	20	+	27661255	K562	viability	GGCGCCCAGGGAACTCCGGGAGG	PRNP	ENSG00000171867	0.05083089233415361	[354,369]	[316,284]	1	dCas9-KRAB	negative selection	5504294
4686892	4686915	20	+	27661255	K562	viability	GGCCGCCAGCGGGCTCCGCAGGG	PRNP	ENSG00000171867	0.23408599950377895	[665,872]	[807,643]	7	dCas9-KRAB	negative selection	5504295
4699817	4699840	20	+	27260156	BXPC3	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.05955158710582287	[278]	[321,242,278,269]	-1	hSpCas9	negative selection	5564738
4699690	4699713	20	+	27260156	BXPC3	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.16291000000936307	[763]	[853,875,873,982]	3	hSpCas9	negative selection	5564739
4699212	4699235	20	+	27260156	BXPC3	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.3555816979956753	[255]	[181,267,175,207]	-7	hSpCas9	negative selection	5564740
4699868	4699891	20	-	27260156	BXPC3	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	-0.02087653948864321	[1179]	[983,1253,1300,1358]	0	hSpCas9	negative selection	5628997
4699858	4699881	20	+	27260156	BXPC3	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.21046254852577148	[491]	[405,395,586,388]	-5	hSpCas9	negative selection	5628998
4699822	4699845	20	-	27260156	BXPC3	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.14982882240116752	[712]	[556,620,768,764]	-3	hSpCas9	negative selection	5628999
4699817	4699840	20	+	27260156	A673	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.10807358418662538	[278]	[252,228,340,420]	-3	hSpCas9	negative selection	5685989
4699690	4699713	20	+	27260156	A673	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.018236646405438983	[763]	[1020,898,907,895]	0	hSpCas9	negative selection	5685990
4699212	4699235	20	+	27260156	A673	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.198937065800331	[255]	[328,272,238,234]	-5	hSpCas9	negative selection	5685991
4699868	4699891	20	-	27260156	A673	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.12051528733693617	[1179]	[1633,1235,1747,1557]	3	hSpCas9	negative selection	5750248
4699858	4699881	20	+	27260156	A673	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.09143533036417982	[491]	[552,546,514,604]	-2	hSpCas9	negative selection	5750249
4699822	4699845	20	-	27260156	A673	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.04802436802063759	[712]	[1023,846,820,862]	1	hSpCas9	negative selection	5750250
4699817	4699840	20	+	27260156	A375	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.14210886005626144	[278]	[206,357,298,320]	-2	hSpCas9	negative selection	5807240
4699690	4699713	20	+	27260156	A375	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.3558792972326734	[763]	[992,1354,1147,1100]	5	hSpCas9	negative selection	5807241
4699212	4699235	20	+	27260156	A375	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.23388479331925682	[255]	[237,228,231,306]	-3	hSpCas9	negative selection	5807242
4699868	4699891	20	-	27260156	A375	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.14686165019906783	[1179]	[1433,2045,1612,1124]	2	hSpCas9	negative selection	5871499
4699858	4699881	20	+	27260156	A375	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.02994308104229232	[491]	[576,841,614,371]	0	hSpCas9	negative selection	5871500
4699822	4699845	20	-	27260156	A375	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.12643189429613277	[712]	[843,1005,663,589]	-2	hSpCas9	negative selection	5871501
4699817	4699840	20	+	27260156	COLO741	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.03639128432179406	[278]	[380,360,305]	-1	hSpCas9	negative selection	5928491
4699690	4699713	20	+	27260156	COLO741	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.3188818645263529	[763]	[1262,1243,1151]	6	hSpCas9	negative selection	5928492
4699212	4699235	20	+	27260156	COLO741	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.09009668563861994	[255]	[260,371,285]	-2	hSpCas9	negative selection	5928493
4699868	4699891	20	-	27260156	COLO741	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.06964702744923179	[1179]	[1966,1433,1388]	1	hSpCas9	negative selection	5992750
4699858	4699881	20	+	27260156	COLO741	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.19364045037469665	[491]	[615,650,397]	-4	hSpCas9	negative selection	5992751
4699822	4699845	20	-	27260156	COLO741	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.016512854699638257	[712]	[1010,839,918]	0	hSpCas9	negative selection	5992752
4699817	4699840	20	+	27260156	CAL120	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.08387719695719831	[278]	[253,360,355]	-1	hSpCas9	negative selection	6049742
4699690	4699713	20	+	27260156	CAL120	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.4155257000114452	[763]	[1900,1185,819]	6	hSpCas9	negative selection	6049743
4699212	4699235	20	+	27260156	CAL120	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.30394788431896325	[255]	[303,165,309]	-4	hSpCas9	negative selection	6049744
4699868	4699891	20	-	27260156	CAL120	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.21720863154010028	[1179]	[2120,1439,1622]	3	hSpCas9	negative selection	6114001
4699858	4699881	20	+	27260156	CAL120	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.14123737553254506	[491]	[718,535,436]	-2	hSpCas9	negative selection	6114002
4699822	4699845	20	-	27260156	CAL120	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.07368593418904845	[712]	[1241,882,725]	1	hSpCas9	negative selection	6114003
4699817	4699840	20	+	27260156	CADOES1	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.010152541673536408	[278]	[181,138,339,388]	0	hSpCas9	negative selection	6170993
4699690	4699713	20	+	27260156	CADOES1	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.0827597731381785	[763]	[656,655,767,935]	1	hSpCas9	negative selection	6170994
4699212	4699235	20	+	27260156	CADOES1	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.5935927653385987	[255]	[151,138,133,207]	-8	hSpCas9	negative selection	6170995
4699868	4699891	20	-	27260156	CADOES1	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	-0.03007967286215929	[1179]	[1249,938,972,1138]	0	hSpCas9	negative selection	6235252
4699858	4699881	20	+	27260156	CADOES1	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.09455915402104434	[491]	[382,577,367,383]	-2	hSpCas9	negative selection	6235253
4699822	4699845	20	-	27260156	CADOES1	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.2518124824025078	[712]	[510,540,561,615]	-4	hSpCas9	negative selection	6235254
4699817	4699840	20	+	27260156	EWS502	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.32619847158138254	[278]	[260,498,427,295]	6	hSpCas9	negative selection	6292244
4699690	4699713	20	+	27260156	EWS502	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.05009250544208921	[763]	[792,1011,723,813]	0	hSpCas9	negative selection	6292245
4699212	4699235	20	+	27260156	EWS502	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.1197962122569266	[255]	[291,188,323,185]	-2	hSpCas9	negative selection	6292246
4699868	4699891	20	-	27260156	EWS502	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.0037318253073512775	[1179]	[915,1155,1475,1526]	0	hSpCas9	negative selection	6356503
4699858	4699881	20	+	27260156	EWS502	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.11252212994518737	[491]	[534,346,439,611]	-2	hSpCas9	negative selection	6356504
4699822	4699845	20	-	27260156	EWS502	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.028247477676484167	[712]	[725,733,911,709]	0	hSpCas9	negative selection	6356505
4699817	4699840	20	+	27260156	EW8	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.4681797995800341	[278]	[187,164,169,131]	-7	hSpCas9	negative selection	6413495
4699690	4699713	20	+	27260156	EW8	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.0554812496238718	[763]	[694,633,562,698]	1	hSpCas9	negative selection	6413496
4699212	4699235	20	+	27260156	EW8	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.6353777976558413	[255]	[140,117,94,186]	-8	hSpCas9	negative selection	6413497
4699868	4699891	20	-	27260156	EW8	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	-0.04995245991640229	[1179]	[1078,845,924,858]	-1	hSpCas9	negative selection	6477754
4699858	4699881	20	+	27260156	EW8	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.17181544830374332	[491]	[396,377,400,235]	-3	hSpCas9	negative selection	6477755
4699822	4699845	20	-	27260156	EW8	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.1693962690733939	[712]	[489,596,397,585]	-3	hSpCas9	negative selection	6477756
4699817	4699840	20	+	27260156	CORL105	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.3322363981058032	[278]	[186,302,351,206]	-6	hSpCas9	negative selection	6534746
4699690	4699713	20	+	27260156	CORL105	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.19208485061097746	[763]	[873,848,1360,1053]	3	hSpCas9	negative selection	6534747
4699212	4699235	20	+	27260156	CORL105	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.16120122959518846	[255]	[217,271,311,274]	-3	hSpCas9	negative selection	6534748
4699868	4699891	20	-	27260156	CORL105	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	-0.03887929098130827	[1179]	[1351,1198,1714,1173]	0	hSpCas9	negative selection	6599005
4699858	4699881	20	+	27260156	CORL105	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.04128594982256274	[491]	[601,588,572,477]	-1	hSpCas9	negative selection	6599006
4699822	4699845	20	-	27260156	CORL105	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.05121440471601235	[712]	[855,854,933,824]	0	hSpCas9	negative selection	6599007
4699817	4699840	20	+	27260156	HS294T	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.06259775889694452	[278]	[33,208,86,126]	0	hSpCas9	negative selection	6655997
4699690	4699713	20	+	27260156	HS294T	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.4642297453348141	[763]	[288,326,654,364]	6	hSpCas9	negative selection	6655998
4699212	4699235	20	+	27260156	HS294T	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.6187084493369489	[255]	[40,59,84,75]	-7	hSpCas9	negative selection	6655999
4699868	4699891	20	-	27260156	HS294T	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	-0.11283000249904807	[1179]	[279,483,451,493]	-1	hSpCas9	negative selection	6720256
4699858	4699881	20	+	27260156	HS294T	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.19151346595345134	[491]	[223,241,226,164]	2	hSpCas9	negative selection	6720257
4699822	4699845	20	-	27260156	HS294T	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.28777946688860323	[712]	[216,199,242,247]	-4	hSpCas9	negative selection	6720258
4699817	4699840	20	+	27260156	HCC44	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.11003471245738927	[278]	[159,337,390,276]	-2	hSpCas9	negative selection	6777248
4699690	4699713	20	+	27260156	HCC44	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.43797262208540166	[763]	[1692,661,1602,917]	7	hSpCas9	negative selection	6777249
4699212	4699235	20	+	27260156	HCC44	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.04915777166903024	[255]	[166,220,461,295]	-1	hSpCas9	negative selection	6777250
4699868	4699891	20	-	27260156	HCC44	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.12567854950723678	[1179]	[2111,1022,1703,1147]	2	hSpCas9	negative selection	6841507
4699858	4699881	20	+	27260156	HCC44	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.21293758395380927	[491]	[412,672,716,754]	3	hSpCas9	negative selection	6841508
4699822	4699845	20	-	27260156	HCC44	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.06429215584941628	[712]	[944,797,662,940]	1	hSpCas9	negative selection	6841509
4699817	4699840	20	+	27260156	G402	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.0007074937581197371	[278]	[304,442,444,176]	0	hSpCas9	negative selection	6898499
4699690	4699713	20	+	27260156	G402	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.4954255415840667	[763]	[1489,1771,966,1085]	6	hSpCas9	negative selection	6898500
4699212	4699235	20	+	27260156	G402	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.059266228749906946	[255]	[326,111,196,542]	0	hSpCas9	negative selection	6898501
4699868	4699891	20	-	27260156	G402	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.035313324384751876	[1179]	[1871,1428,1621,1048]	0	hSpCas9	negative selection	6962758
4699858	4699881	20	+	27260156	G402	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.09298893355180257	[491]	[803,663,416,695]	1	hSpCas9	negative selection	6962759
4699822	4699845	20	-	27260156	G402	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.10325008738721153	[712]	[854,1086,665,1114]	1	hSpCas9	negative selection	6962760
4699817	4699840	20	+	27260156	L33	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.07629371384065109	[278]	[328,130,151,284]	1	hSpCas9	negative selection	7019750
4699690	4699713	20	+	27260156	L33	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	-0.17078909724431512	[763]	[642,240,461,748]	-4	hSpCas9	negative selection	7019751
4699212	4699235	20	+	27260156	L33	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.12511980801395584	[255]	[167,106,148,273]	-3	hSpCas9	negative selection	7019752
4699868	4699891	20	-	27260156	L33	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.12167516122523381	[1179]	[1156,534,816,1374]	2	hSpCas9	negative selection	7084009
4699858	4699881	20	+	27260156	L33	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.031179679341306943	[491]	[446,206,329,449]	0	hSpCas9	negative selection	7084010
4699822	4699845	20	-	27260156	L33	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.04896669301441714	[712]	[803,264,522,666]	1	hSpCas9	negative selection	7084011
4699817	4699840	20	+	27260156	K562	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.14511322745600264	[278]	[229,330,268,86]	-2	hSpCas9	negative selection	7141001
4699690	4699713	20	+	27260156	K562	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.40905847950992724	[763]	[1506,573,1037,551]	5	hSpCas9	negative selection	7141002
4699212	4699235	20	+	27260156	K562	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	0.2311778069561201	[255]	[135,421,313,198]	3	hSpCas9	negative selection	7141003
4699868	4699891	20	-	27260156	K562	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.3487941495943616	[1179]	[1138,1977,1334,940]	4	hSpCas9	negative selection	7205260
4699858	4699881	20	+	27260156	K562	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.16479483182180243	[491]	[536,401,447,203]	-2	hSpCas9	negative selection	7205261
4699822	4699845	20	-	27260156	K562	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.771833826828306	[712]	[465,358,443,234]	-7	hSpCas9	negative selection	7205262
4699817	4699840	20	+	27260156	HT29	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.06591888174467164	[278]	[470,246,405,299]	1	hSpCas9	negative selection	7262252
4699690	4699713	20	+	27260156	HT29	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.2739186905149973	[763]	[1368,1149,1080,928]	5	hSpCas9	negative selection	7262253
4699212	4699235	20	+	27260156	HT29	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.002556432391231378	[255]	[300,433,247,271]	0	hSpCas9	negative selection	7262254
4699868	4699891	20	-	27260156	HT29	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.07561808539336567	[1179]	[1629,1694,1409,1345]	1	hSpCas9	negative selection	7326511
4699858	4699881	20	+	27260156	HT29	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.18409201500116662	[491]	[554,547,521,485]	-4	hSpCas9	negative selection	7326512
4699822	4699845	20	-	27260156	HT29	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.023194032320676516	[712]	[987,924,781,740]	0	hSpCas9	negative selection	7326513
4699817	4699840	20	+	27260156	MHHES1	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.09636509802486903	[278]	[272,337,473,261]	1	hSpCas9	negative selection	7383503
4699690	4699713	20	+	27260156	MHHES1	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.011766974698038779	[763]	[1064,831,1078,566]	0	hSpCas9	negative selection	7383504
4699212	4699235	20	+	27260156	MHHES1	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.41996680117318375	[255]	[233,297,230,125]	-7	hSpCas9	negative selection	7383505
4699868	4699891	20	-	27260156	MHHES1	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.09056707317223256	[1179]	[1416,1557,1660,1085]	1	hSpCas9	negative selection	7447762
4699858	4699881	20	+	27260156	MHHES1	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.25462931328924276	[491]	[418,1485,514,338]	5	hSpCas9	negative selection	7447763
4699822	4699845	20	-	27260156	MHHES1	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.32011255149452494	[712]	[704,785,724,417]	-6	hSpCas9	negative selection	7447764
4699817	4699840	20	+	27260156	MEWO	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.01966222313188426	[278]	[315,204,262]	0	hSpCas9	negative selection	7504754
4699690	4699713	20	+	27260156	MEWO	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.1718152681283659	[763]	[1012,721,720]	4	hSpCas9	negative selection	7504755
4699212	4699235	20	+	27260156	MEWO	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.13746723772200997	[255]	[189,173,283]	-3	hSpCas9	negative selection	7504756
4699868	4699891	20	-	27260156	MEWO	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	-0.0009844927008313409	[1179]	[1238,1039,1056]	0	hSpCas9	negative selection	7569013
4699858	4699881	20	+	27260156	MEWO	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.10095963474712907	[491]	[656,346,327]	-2	hSpCas9	negative selection	7569014
4699822	4699845	20	-	27260156	MEWO	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.22797260504472439	[712]	[595,499,617]	-5	hSpCas9	negative selection	7569015
4699817	4699840	20	+	27260156	LNCAPCLONEFGC	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.11302475933307177	[278]	[216,296,221,192]	-2	hSpCas9	negative selection	7626005
4699690	4699713	20	+	27260156	LNCAPCLONEFGC	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.05387999794107079	[763]	[568,748,697,854]	0	hSpCas9	negative selection	7626006
4699212	4699235	20	+	27260156	LNCAPCLONEFGC	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	0.28805399330925463	[255]	[205,372,269,276]	4	hSpCas9	negative selection	7626007
4699868	4699891	20	-	27260156	LNCAPCLONEFGC	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	-0.03344672438561602	[1179]	[1066,893,1128,1108]	0	hSpCas9	negative selection	7690264
4699858	4699881	20	+	27260156	LNCAPCLONEFGC	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.45127328831948443	[491]	[267,332,370,338]	-6	hSpCas9	negative selection	7690265
4699822	4699845	20	-	27260156	LNCAPCLONEFGC	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.05185083757233844	[712]	[741,683,721,534]	0	hSpCas9	negative selection	7690266
4699817	4699840	20	+	27260156	PANC0327	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.40751305828285783	[278]	[716,193,246,205]	6	hSpCas9	negative selection	7747256
4699690	4699713	20	+	27260156	PANC0327	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.26948373566151684	[763]	[933,747,597,1009]	4	hSpCas9	negative selection	7747257
4699212	4699235	20	+	27260156	PANC0327	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.16134150415884585	[255]	[278,136,166,244]	-2	hSpCas9	negative selection	7747258
4699868	4699891	20	-	27260156	PANC0327	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.20785651686274997	[1179]	[1154,876,1448,1399]	3	hSpCas9	negative selection	7811515
4699858	4699881	20	+	27260156	PANC0327	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.025633018054794267	[491]	[653,302,408,385]	0	hSpCas9	negative selection	7811516
4699822	4699845	20	-	27260156	PANC0327	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.27036757623571805	[712]	[677,512,298,623]	-4	hSpCas9	negative selection	7811517
4699817	4699840	20	+	27260156	NCIH2009	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.12396947375276568	[278]	[361,322,388]	-2	hSpCas9	negative selection	7868507
4699690	4699713	20	+	27260156	NCIH2009	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.4081020682734935	[763]	[1891,1241,1209]	5	hSpCas9	negative selection	7868508
4699212	4699235	20	+	27260156	NCIH2009	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.48407012856194653	[255]	[324,333,119]	-6	hSpCas9	negative selection	7868509
4699868	4699891	20	-	27260156	NCIH2009	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.022088304958741034	[1179]	[2114,1428,1566]	0	hSpCas9	negative selection	7932766
4699858	4699881	20	+	27260156	NCIH2009	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.07719258289265896	[491]	[761,622,590]	-1	hSpCas9	negative selection	7932767
4699822	4699845	20	-	27260156	NCIH2009	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.20932652476537222	[712]	[1218,699,737]	-3	hSpCas9	negative selection	7932768
4699817	4699840	20	+	27260156	NCIH1373	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.4724112350390775	[278]	[1106,228,174,91]	4	hSpCas9	negative selection	7989758
4699690	4699713	20	+	27260156	NCIH1373	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.44045562049528986	[763]	[1200,1348,795,340]	4	hSpCas9	negative selection	7989759
4699212	4699235	20	+	27260156	NCIH1373	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.7009735946157002	[255]	[172,104,302,32]	-6	hSpCas9	negative selection	7989760
4699868	4699891	20	-	27260156	NCIH1373	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.19926239922028732	[1179]	[1816,1221,1382,456]	2	hSpCas9	negative selection	8054017
4699858	4699881	20	+	27260156	NCIH1373	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.6713365077472319	[491]	[269,284,389,114]	-6	hSpCas9	negative selection	8054018
4699822	4699845	20	-	27260156	NCIH1373	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.08915214133669358	[712]	[997,384,949,302]	0	hSpCas9	negative selection	8054019
4699817	4699840	20	+	27260156	PATU8902	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.4010279781741006	[278]	[619,622,440,363]	4	hSpCas9	negative selection	8111009
4699690	4699713	20	+	27260156	PATU8902	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.541908861143972	[763]	[2384,1135,1028,1784]	5	hSpCas9	negative selection	8111010
4699212	4699235	20	+	27260156	PATU8902	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	0.046388069556049794	[255]	[337,426,66,763]	0	hSpCas9	negative selection	8111011
4699868	4699891	20	-	27260156	PATU8902	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.5298012621303696	[1179]	[2886,2337,2104,2180]	5	hSpCas9	negative selection	8175268
4699858	4699881	20	+	27260156	PATU8902	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.2979267448891491	[491]	[580,153,406,1196]	-3	hSpCas9	negative selection	8175269
4699822	4699845	20	-	27260156	PATU8902	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.1359803802292069	[712]	[1160,689,1102,1437]	1	hSpCas9	negative selection	8175270
4699817	4699840	20	+	27260156	PANC1	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.13639231905150984	[278]	[255,180,271,160]	-2	hSpCas9	negative selection	8232260
4699690	4699713	20	+	27260156	PANC1	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.2277969016770507	[763]	[850,925,639,686]	3	hSpCas9	negative selection	8232261
4699212	4699235	20	+	27260156	PANC1	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.31203970772851763	[255]	[257,122,145,166]	-5	hSpCas9	negative selection	8232262
4699868	4699891	20	-	27260156	PANC1	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.07184510803193067	[1179]	[1204,1201,1012,878]	1	hSpCas9	negative selection	8296519
4699858	4699881	20	+	27260156	PANC1	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.07603996443082359	[491]	[349,265,392,537]	-1	hSpCas9	negative selection	8296520
4699822	4699845	20	-	27260156	PANC1	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.15075293484878816	[712]	[583,588,593,453]	-2	hSpCas9	negative selection	8296521
4699817	4699840	20	+	27260156	PANC0813	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.28164903151208304	[278]	[495,478,364,268]	4	hSpCas9	negative selection	8353511
4699690	4699713	20	+	27260156	PANC0813	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.16248819376647228	[763]	[1350,782,1085,837]	2	hSpCas9	negative selection	8353512
4699212	4699235	20	+	27260156	PANC0813	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.35658428154713107	[255]	[355,172,236,186]	-5	hSpCas9	negative selection	8353513
4699868	4699891	20	-	27260156	PANC0813	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.214973466820926	[1179]	[1785,1734,1653,1291]	3	hSpCas9	negative selection	8417770
4699858	4699881	20	+	27260156	PANC0813	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.43160939482172955	[491]	[838,926,832,536]	7	hSpCas9	negative selection	8417771
4699822	4699845	20	-	27260156	PANC0813	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.0301690365148094	[712]	[998,924,828,688]	0	hSpCas9	negative selection	8417772
4699817	4699840	20	+	27260156	RDES	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.6558812326163295	[278]	[183,158,245,233]	-8	hSpCas9	negative selection	8474762
4699690	4699713	20	+	27260156	RDES	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.3052300095392839	[763]	[1031,835,1064,1467]	5	hSpCas9	negative selection	8474763
4699212	4699235	20	+	27260156	RDES	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.7061651934722887	[255]	[118,179,223,213]	-8	hSpCas9	negative selection	8474764
4699868	4699891	20	-	27260156	RDES	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	-0.0837363708844987	[1179]	[1053,1148,1344,1656]	-1	hSpCas9	negative selection	8539021
4699858	4699881	20	+	27260156	RDES	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.3764581206660701	[491]	[423,326,405,610]	-6	hSpCas9	negative selection	8539022
4699822	4699845	20	-	27260156	RDES	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.1808917143440636	[712]	[748,622,744,761]	-3	hSpCas9	negative selection	8539023
4699817	4699840	20	+	27260156	PC3	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.040347348488292356	[278]	[243,370,320,192]	0	hSpCas9	negative selection	8596013
4699690	4699713	20	+	27260156	PC3	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	-0.20985193021527837	[763]	[449,855,1005,456]	-5	hSpCas9	negative selection	8596014
4699212	4699235	20	+	27260156	PC3	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.5119104600532008	[255]	[148,146,234,199]	-8	hSpCas9	negative selection	8596015
4699868	4699891	20	-	27260156	PC3	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	-0.054738177106411934	[1179]	[703,918,1963,1368]	-1	hSpCas9	negative selection	8660272
4699858	4699881	20	+	27260156	PC3	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.046616787707401644	[491]	[313,494,687,506]	-1	hSpCas9	negative selection	8660273
4699822	4699845	20	-	27260156	PC3	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.041150886338149895	[712]	[431,766,975,913]	0	hSpCas9	negative selection	8660274
4699817	4699840	20	+	27260156	PATU8988T	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.2605519449375624	[278]	[259,232,197,208]	-4	hSpCas9	negative selection	8717264
4699690	4699713	20	+	27260156	PATU8988T	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.10763692499662758	[763]	[774,936,789,683]	1	hSpCas9	negative selection	8717265
4699212	4699235	20	+	27260156	PATU8988T	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.1665124647682087	[255]	[154,137,318,263]	-3	hSpCas9	negative selection	8717266
4699868	4699891	20	-	27260156	PATU8988T	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.11534295761605184	[1179]	[942,1059,1422,1517]	2	hSpCas9	negative selection	8781523
4699858	4699881	20	+	27260156	PATU8988T	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.09779760528250762	[491]	[158,607,582,439]	-2	hSpCas9	negative selection	8781524
4699822	4699845	20	-	27260156	PATU8988T	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.3213264152535066	[712]	[996,817,838,778]	5	hSpCas9	negative selection	8781525
4699817	4699840	20	+	27260156	T47D	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.003496498378445456	[278]	[294,386,315,298]	0	hSpCas9	negative selection	8838515
4699690	4699713	20	+	27260156	T47D	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.00515052558047957	[763]	[1055,882,795,838]	0	hSpCas9	negative selection	8838516
4699212	4699235	20	+	27260156	T47D	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.2340394116094423	[255]	[237,268,268,235]	-5	hSpCas9	negative selection	8838517
4699868	4699891	20	-	27260156	T47D	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.07693952925002612	[1179]	[1553,1356,1467,1427]	1	hSpCas9	negative selection	8902774
4699858	4699881	20	+	27260156	T47D	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.04453922819276247	[491]	[504,554,474,841]	0	hSpCas9	negative selection	8902775
4699822	4699845	20	-	27260156	T47D	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.27586423154102463	[712]	[715,633,717,679]	-6	hSpCas9	negative selection	8902776
4699817	4699840	20	+	27260156	SU8686	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.17074460677400993	[278]	[181,289,197,323]	-3	hSpCas9	negative selection	8959766
4699690	4699713	20	+	27260156	SU8686	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.2364867182919671	[763]	[940,794,720,1149]	4	hSpCas9	negative selection	8959767
4699212	4699235	20	+	27260156	SU8686	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.15455072866983477	[255]	[213,248,198,249]	-3	hSpCas9	negative selection	8959768
4699868	4699891	20	-	27260156	SU8686	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.12691903709790786	[1179]	[1356,1185,1022,1578]	2	hSpCas9	negative selection	9024025
4699858	4699881	20	+	27260156	SU8686	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.11531930180294861	[491]	[387,611,502,626]	2	hSpCas9	negative selection	9024026
4699822	4699845	20	-	27260156	SU8686	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.1461223782776283	[712]	[560,763,772,1104]	2	hSpCas9	negative selection	9024027
4699817	4699840	20	+	27260156	SKES1	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.0230149360138725	[278]	[400,298,226,226]	0	hSpCas9	negative selection	9081017
4699690	4699713	20	+	27260156	SKES1	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.11601952380274272	[763]	[782,1099,638,804]	2	hSpCas9	negative selection	9081018
4699212	4699235	20	+	27260156	SKES1	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.1151205505394084	[255]	[292,232,229,196]	-3	hSpCas9	negative selection	9081019
4699868	4699891	20	-	27260156	SKES1	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	-0.03604492023687822	[1179]	[1289,1241,1018,1070]	-1	hSpCas9	negative selection	9145276
4699858	4699881	20	+	27260156	SKES1	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.09525669896389105	[491]	[422,491,501,418]	-2	hSpCas9	negative selection	9145277
4699822	4699845	20	-	27260156	SKES1	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.007652038535772676	[712]	[640,817,794,611]	0	hSpCas9	negative selection	9145278
4699817	4699840	20	+	27260156	TOV112D	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	0.17326444205094071	[278]	[311,406,240,321]	3	hSpCas9	negative selection	9202268
4699690	4699713	20	+	27260156	TOV112D	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	-0.0021063799264702254	[763]	[689,1183,654,626]	0	hSpCas9	negative selection	9202269
4699212	4699235	20	+	27260156	TOV112D	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.3417591285578422	[255]	[177,208,199,220]	-6	hSpCas9	negative selection	9202270
4699868	4699891	20	-	27260156	TOV112D	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.10688524361368756	[1179]	[1292,1518,882,1450]	2	hSpCas9	negative selection	9266527
4699858	4699881	20	+	27260156	TOV112D	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.07362440211922718	[491]	[345,455,410,640]	-1	hSpCas9	negative selection	9266528
4699822	4699845	20	-	27260156	TOV112D	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.1109743074885291	[712]	[969,741,642,738]	2	hSpCas9	negative selection	9266529
4699817	4699840	20	+	27260156	TC71	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.0954387945287204	[278]	[217,242,335,324]	-2	hSpCas9	negative selection	9323519
4699690	4699713	20	+	27260156	TC71	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	-0.027693634867550276	[763]	[734,794,794,895]	0	hSpCas9	negative selection	9323520
4699212	4699235	20	+	27260156	TC71	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	-0.007852080454443855	[255]	[269,314,234,272]	0	hSpCas9	negative selection	9323521
4699868	4699891	20	-	27260156	TC71	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	-0.09593355983964313	[1179]	[988,1295,1202,1253]	-2	hSpCas9	negative selection	9387778
4699858	4699881	20	+	27260156	TC71	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.28084265506507755	[491]	[352,524,390,472]	-6	hSpCas9	negative selection	9387779
4699822	4699845	20	-	27260156	TC71	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.03501248399222401	[712]	[720,752,532,999]	-1	hSpCas9	negative selection	9387780
4699817	4699840	20	+	27260156	TC32	viability	CGAGACCGACGTTAAGATGATGG	PRNP	ENSG00000171867	-0.13453468475919483	[278]	[172,96,315,444]	-2	hSpCas9	negative selection	9444770
4699690	4699713	20	+	27260156	TC32	viability	ACCCCAACCAAGTGTACTACAGG	PRNP	ENSG00000171867	0.06900701641374862	[763]	[637,666,976,770]	1	hSpCas9	negative selection	9444771
4699212	4699235	20	+	27260156	TC32	viability	GCAGTCATTATGGCGAACCTTGG	PRNP	ENSG00000171867	0.0035648529738030454	[255]	[180,249,226,295]	0	hSpCas9	negative selection	9444772
4699868	4699891	20	-	27260156	TC32	viability	CCTGAGATTCCCTCTCGTACTGG	PRNP	ENSG00000171867	0.0014716206052358682	[1179]	[894,868,1368,1422]	0	hSpCas9	negative selection	9509029
4699858	4699881	20	+	27260156	TC32	viability	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	-0.17144292751226117	[491]	[294,341,565,486]	-3	hSpCas9	negative selection	9509030
4699822	4699845	20	-	27260156	TC32	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.08547573080322646	[712]	[588,481,672,823]	-1	hSpCas9	negative selection	9509031
4699246	4699269	20	+	27869803	HPAFII	viability after 27 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	0.10712987470641622	[82]	[64,31,NaN]	0	hSpCas9	negative selection	9578033
4699291	4699314	20	+	27869803	HPAFII	viability after 27 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.7346199160334568	[296]	[291,232,NaN]	6	hSpCas9	negative selection	9578034
4699783	4699806	20	+	27869803	HPAFII	viability after 27 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	-1.0070961860969945	[472]	[144,105,NaN]	-6	hSpCas9	negative selection	9578035
4699826	4699849	20	+	27869803	HPAFII	viability after 27 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-2.4393390254720555	[150]	[0,25,NaN]	-8	hSpCas9	negative selection	9578036
4699858	4699881	20	+	27869803	HPAFII	viability after 27 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.8918445576359224	[731]	[538,859,NaN]	7	hSpCas9	negative selection	9578037
4699884	4699907	20	+	27869803	HPAFII	viability after 27 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.5484764006859233	[309]	[311,176,NaN]	4	hSpCas9	negative selection	9578038
4699246	4699269	20	+	27869803	HPAFII	viability after 15 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	0.5266306699966359	[82]	[146,116,NaN]	6	hSpCas9	negative selection	9660482
4699291	4699314	20	+	27869803	HPAFII	viability after 15 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.5505509590919531	[296]	[715,312,NaN]	6	hSpCas9	negative selection	9660483
4699783	4699806	20	+	27869803	HPAFII	viability after 15 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	-0.7225613982247321	[472]	[505,184,NaN]	-6	hSpCas9	negative selection	9660484
4699826	4699849	20	+	27869803	HPAFII	viability after 15 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-0.5619928662315383	[150]	[30,158,NaN]	-6	hSpCas9	negative selection	9660485
4699858	4699881	20	+	27869803	HPAFII	viability after 15 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.1958336445115776	[731]	[1016,828,NaN]	2	hSpCas9	negative selection	9660486
4699884	4699907	20	+	27869803	HPAFII	viability after 15 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.41024692919870825	[309]	[607,339,NaN]	5	hSpCas9	negative selection	9660487
4699246	4699269	20	+	27869803	ASPC1	viability after 36 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	-0.7415550617678537	[273]	[104,50,27]	-6	hSpCas9	negative selection	9742931
4699291	4699314	20	+	27869803	ASPC1	viability after 36 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.8492830910368944	[743]	[262,265,766]	7	hSpCas9	negative selection	9742932
4699783	4699806	20	+	27869803	ASPC1	viability after 36 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	-0.08654875692720715	[912]	[509,57,341]	-1	hSpCas9	negative selection	9742933
4699826	4699849	20	+	27869803	ASPC1	viability after 36 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	2.229740535579424	[177]	[369,156,339]	9	hSpCas9	negative selection	9742934
4699858	4699881	20	+	27869803	ASPC1	viability after 36 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.059666715815581695	[1754]	[730,495,679]	0	hSpCas9	negative selection	9742935
4699884	4699907	20	+	27869803	ASPC1	viability after 36 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	-0.40280214022578553	[765]	[181,310,127]	-4	hSpCas9	negative selection	9742936
4699246	4699269	20	+	27869803	PATU8988S	viability after 35 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	-0.22476617613216954	[269]	[116,68,NaN]	-2	hSpCas9	negative selection	9825380
4699291	4699314	20	+	27869803	PATU8988S	viability after 35 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	-0.06836886118481705	[701]	[113,425,NaN]	0	hSpCas9	negative selection	9825381
4699783	4699806	20	+	27869803	PATU8988S	viability after 35 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.04248343471303684	[799]	[256,406,NaN]	0	hSpCas9	negative selection	9825382
4699826	4699849	20	+	27869803	PATU8988S	viability after 35 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	0.40501180312917384	[198]	[159,51,NaN]	4	hSpCas9	negative selection	9825383
4699858	4699881	20	+	27869803	PATU8988S	viability after 35 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.3584991083475706	[1514]	[908,654,NaN]	4	hSpCas9	negative selection	9825384
4699884	4699907	20	+	27869803	PATU8988S	viability after 35 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.08467434046066391	[706]	[282,320,NaN]	1	hSpCas9	negative selection	9825385
4699246	4699269	20	+	27869803	PATU8988S	viability after 31 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	-0.38921028170925065	[269]	[101,56,NaN]	-4	hSpCas9	negative selection	9907829
4699291	4699314	20	+	27869803	PATU8988S	viability after 31 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	-0.43856900622940387	[701]	[118,317,NaN]	-5	hSpCas9	negative selection	9907830
4699783	4699806	20	+	27869803	PATU8988S	viability after 31 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	0.4572113244584962	[799]	[356,540,NaN]	5	hSpCas9	negative selection	9907831
4699826	4699849	20	+	27869803	PATU8988S	viability after 31 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	0.4346687827043336	[198]	[152,48,NaN]	5	hSpCas9	negative selection	9907832
4699858	4699881	20	+	27869803	PATU8988S	viability after 31 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.42863760152884156	[1514]	[864,746,NaN]	5	hSpCas9	negative selection	9907833
4699884	4699907	20	+	27869803	PATU8988S	viability after 31 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.18586197514025732	[706]	[288,360,NaN]	2	hSpCas9	negative selection	9907834
4699246	4699269	20	+	27869803	HPAFII	viability after 35 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	-1.1091579123496584	[82]	[34,1,NaN]	-6	hSpCas9	negative selection	9990278
4699291	4699314	20	+	27869803	HPAFII	viability after 35 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.8587081946154459	[296]	[290,251,NaN]	5	hSpCas9	negative selection	9990279
4699783	4699806	20	+	27869803	HPAFII	viability after 35 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	-1.230288268973486	[472]	[110,91,NaN]	-6	hSpCas9	negative selection	9990280
4699826	4699849	20	+	27869803	HPAFII	viability after 35 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-2.338820276188065	[150]	[0,30,NaN]	-8	hSpCas9	negative selection	9990281
4699858	4699881	20	+	27869803	HPAFII	viability after 35 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.8500247139302985	[731]	[484,873,NaN]	5	hSpCas9	negative selection	9990282
4699884	4699907	20	+	27869803	HPAFII	viability after 35 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.6548622698525317	[309]	[311,173,NaN]	4	hSpCas9	negative selection	9990283
4699246	4699269	20	+	27869803	HPAFII	viability after 31 days	TGGTTCTCTTTGTGGCCACATGG	PRNP	ENSG00000171867	0.4557532242265565	[82]	[105,17,NaN]	3	hSpCas9	negative selection	10072727
4699291	4699314	20	+	27869803	HPAFII	viability after 31 days	AGCGCCCGAAGCCTGGAGGATGG	PRNP	ENSG00000171867	0.8844327123206744	[296]	[300,314,NaN]	6	hSpCas9	negative selection	10072728
4699783	4699806	20	+	27869803	HPAFII	viability after 31 days	CGGTCACCACAACCACCAAGGGG	PRNP	ENSG00000171867	-1.179144751716569	[472]	[99,135,NaN]	-6	hSpCas9	negative selection	10072729
4699826	4699849	20	+	27869803	HPAFII	viability after 31 days	CGTTAAGATGATGGAGCGCGTGG	PRNP	ENSG00000171867	-2.262853528690413	[150]	[9,25,NaN]	-8	hSpCas9	negative selection	10072730
4699858	4699881	20	+	27869803	HPAFII	viability after 31 days	TGTGTATCACCCAGTACGAGAGG	PRNP	ENSG00000171867	0.7906087445178984	[731]	[556,877,NaN]	6	hSpCas9	negative selection	10072731
4699884	4699907	20	+	27869803	HPAFII	viability after 31 days	TCTCAGGCCTATTACCAGAGAGG	PRNP	ENSG00000171867	0.6195628217567359	[309]	[340,186,NaN]	4	hSpCas9	negative selection	10072732
4699782	4699805	20	+	28162770	P31FUJ	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	0.15167782788849538	[333]	[435]	1	hSpCas9	negative selection	10217393
4699261	4699284	20	-	28162770	P31FUJ	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	-0.05036893109604246	[318]	[361]	0	hSpCas9	negative selection	10217394
4699932	4699955	20	-	28162770	P31FUJ	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-1.3903434814008588	[28]	[12]	-7	hSpCas9	negative selection	10217395
4699287	4699310	20	+	28162770	P31FUJ	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	-0.2328022044143787	[208]	[208]	-2	hSpCas9	negative selection	10217396
4699448	4699471	20	-	28162770	P31FUJ	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	0.06061946278398944	[367]	[450]	0	hSpCas9	negative selection	10217397
4699476	4699499	20	+	28162770	P31FUJ	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-0.6525161909026957	[205]	[153]	-5	hSpCas9	negative selection	10217398
4699495	4699518	20	+	28162770	P31FUJ	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.4271223539879997	[299]	[473]	5	hSpCas9	negative selection	10217399
4699822	4699845	20	-	28162770	P31FUJ	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.13500839046641488	[441]	[472]	-1	hSpCas9	negative selection	10217400
4699859	4699882	20	+	28162770	P31FUJ	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-0.22434062566618274	[169]	[170]	-2	hSpCas9	negative selection	10217401
4699229	4699252	20	-	28162770	P31FUJ	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.38949644757975027	[177]	[273]	4	hSpCas9	negative selection	10217402
4699782	4699805	20	+	28162770	TF1	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	NaN	[NaN]	[426]	1	hSpCas9	negative selection	10386759
4699261	4699284	20	-	28162770	TF1	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	NaN	[NaN]	[281]	1	hSpCas9	negative selection	10386760
4699932	4699955	20	-	28162770	TF1	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	NaN	[NaN]	[6]	1	hSpCas9	negative selection	10386761
4699287	4699310	20	+	28162770	TF1	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	NaN	[NaN]	[189]	1	hSpCas9	negative selection	10386762
4699448	4699471	20	-	28162770	TF1	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	NaN	[NaN]	[351]	1	hSpCas9	negative selection	10386763
4699476	4699499	20	+	28162770	TF1	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	NaN	[NaN]	[47]	1	hSpCas9	negative selection	10386764
4699495	4699518	20	+	28162770	TF1	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	NaN	[NaN]	[398]	1	hSpCas9	negative selection	10386765
4699822	4699845	20	-	28162770	TF1	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	NaN	[NaN]	[335]	1	hSpCas9	negative selection	10386766
4699859	4699882	20	+	28162770	TF1	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	NaN	[NaN]	[99]	1	hSpCas9	negative selection	10386767
4699229	4699252	20	-	28162770	TF1	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	NaN	[NaN]	[207]	1	hSpCas9	negative selection	10386768
4699782	4699805	20	+	28162770	SKM1	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	0.05012347942583628	[111]	[204]	0	hSpCas9	negative selection	10556125
4699261	4699284	20	-	28162770	SKM1	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	0.9345721807693497	[94]	[320]	8	hSpCas9	negative selection	10556126
4699932	4699955	20	-	28162770	SKM1	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-0.7345388567716662	[15]	[16]	-5	hSpCas9	negative selection	10556127
4699287	4699310	20	+	28162770	SKM1	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.5211428827750526	[53]	[136]	5	hSpCas9	negative selection	10556128
4699448	4699471	20	-	28162770	SKM1	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	-0.4312117449898392	[89]	[117]	-4	hSpCas9	negative selection	10556129
4699476	4699499	20	+	28162770	SKM1	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-0.8436967691213246	[66]	[65]	-6	hSpCas9	negative selection	10556130
4699495	4699518	20	+	28162770	SKM1	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.3943162089047582	[67]	[157]	4	hSpCas9	negative selection	10556131
4699822	4699845	20	-	28162770	SKM1	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.011639915555874403	[100]	[179]	0	hSpCas9	negative selection	10556132
4699859	4699882	20	+	28162770	SKM1	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-0.9422959317397175	[49]	[45]	-6	hSpCas9	negative selection	10556133
4699229	4699252	20	-	28162770	SKM1	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.2654611432283338	[39]	[84]	2	hSpCas9	negative selection	10556134
4699782	4699805	20	+	28162770	SKM1	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	0.05012347942583628	[111]	[204]	0	hSpCas9	negative selection	10725491
4699261	4699284	20	-	28162770	SKM1	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	0.9345721807693497	[94]	[320]	8	hSpCas9	negative selection	10725492
4699932	4699955	20	-	28162770	SKM1	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-0.7345388567716662	[15]	[16]	-5	hSpCas9	negative selection	10725493
4699287	4699310	20	+	28162770	SKM1	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.5211428827750526	[53]	[136]	5	hSpCas9	negative selection	10725494
4699448	4699471	20	-	28162770	SKM1	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	-0.4312117449898392	[89]	[117]	-4	hSpCas9	negative selection	10725495
4699476	4699499	20	+	28162770	SKM1	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-0.8436967691213246	[66]	[65]	-6	hSpCas9	negative selection	10725496
4699495	4699518	20	+	28162770	SKM1	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.3943162089047582	[67]	[157]	4	hSpCas9	negative selection	10725497
4699822	4699845	20	-	28162770	SKM1	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.011639915555874403	[100]	[179]	0	hSpCas9	negative selection	10725498
4699859	4699882	20	+	28162770	SKM1	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-0.9422959317397175	[49]	[45]	-6	hSpCas9	negative selection	10725499
4699229	4699252	20	-	28162770	SKM1	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.2654611432283338	[39]	[84]	2	hSpCas9	negative selection	10725500
4699782	4699805	20	+	28162770	PL21	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	0.09885627865213831	[353]	[164]	0	hSpCas9	negative selection	10894857
4699261	4699284	20	-	28162770	PL21	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	-0.6177459750604534	[274]	[77]	-4	hSpCas9	negative selection	10894858
4699932	4699955	20	-	28162770	PL21	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-2.1748998168576046	[82]	[7]	-8	hSpCas9	negative selection	10894859
4699287	4699310	20	+	28162770	PL21	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.18964724067167782	[275]	[136]	1	hSpCas9	negative selection	10894860
4699448	4699471	20	-	28162770	PL21	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	0.5713228241787367	[333]	[215]	5	hSpCas9	negative selection	10894861
4699476	4699499	20	+	28162770	PL21	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-0.5756452285674141	[225]	[65]	-4	hSpCas9	negative selection	10894862
4699495	4699518	20	+	28162770	PL21	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.2784679751742796	[232]	[122]	2	hSpCas9	negative selection	10894863
4699822	4699845	20	-	28162770	PL21	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-1.5747938298759063	[307]	[44]	-7	hSpCas9	negative selection	10894864
4699859	4699882	20	+	28162770	PL21	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-1.1217884803980422	[119]	[23]	-6	hSpCas9	negative selection	10894865
4699229	4699252	20	-	28162770	PL21	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.4261432893781469	[170]	[99]	4	hSpCas9	negative selection	10894866
4699782	4699805	20	+	28162770	P31FUJ	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	0.15167782788849538	[333]	[435]	1	hSpCas9	negative selection	11064223
4699261	4699284	20	-	28162770	P31FUJ	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	-0.05036893109604246	[318]	[361]	0	hSpCas9	negative selection	11064224
4699932	4699955	20	-	28162770	P31FUJ	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-1.3903434814008588	[28]	[12]	-7	hSpCas9	negative selection	11064225
4699287	4699310	20	+	28162770	P31FUJ	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	-0.2328022044143787	[208]	[208]	-2	hSpCas9	negative selection	11064226
4699448	4699471	20	-	28162770	P31FUJ	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	0.06061946278398944	[367]	[450]	0	hSpCas9	negative selection	11064227
4699476	4699499	20	+	28162770	P31FUJ	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-0.6525161909026957	[205]	[153]	-5	hSpCas9	negative selection	11064228
4699495	4699518	20	+	28162770	P31FUJ	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.4271223539879997	[299]	[473]	5	hSpCas9	negative selection	11064229
4699822	4699845	20	-	28162770	P31FUJ	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.13500839046641488	[441]	[472]	-1	hSpCas9	negative selection	11064230
4699859	4699882	20	+	28162770	P31FUJ	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-0.22434062566618274	[169]	[170]	-2	hSpCas9	negative selection	11064231
4699229	4699252	20	-	28162770	P31FUJ	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.38949644757975027	[177]	[273]	4	hSpCas9	negative selection	11064232
4699782	4699805	20	+	28162770	OCIAML5	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	0.2064856114911161	[168]	[351]	1	hSpCas9	negative selection	11233589
4699261	4699284	20	-	28162770	OCIAML5	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	1.057650068823285	[135]	[510]	8	hSpCas9	negative selection	11233590
4699932	4699955	20	-	28162770	OCIAML5	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-0.09125423474342309	[35]	[60]	0	hSpCas9	negative selection	11233591
4699287	4699310	20	+	28162770	OCIAML5	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	1.27775166962296	[76]	[336]	9	hSpCas9	negative selection	11233592
4699448	4699471	20	-	28162770	OCIAML5	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	0.22168176911731552	[142]	[300]	1	hSpCas9	negative selection	11233593
4699476	4699499	20	+	28162770	OCIAML5	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-3.5799870254271964	[105]	[15]	-9	hSpCas9	negative selection	11233594
4699495	4699518	20	+	28162770	OCIAML5	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	1.028945392918916	[179]	[662]	8	hSpCas9	negative selection	11233595
4699822	4699845	20	-	28162770	OCIAML5	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.019609332160463566	[234]	[429]	0	hSpCas9	negative selection	11233596
4699859	4699882	20	+	28162770	OCIAML5	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	1.3947910908131795	[70]	[336]	9	hSpCas9	negative selection	11233597
4699229	4699252	20	-	28162770	OCIAML5	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.5970641270832548	[114]	[313]	5	hSpCas9	negative selection	11233598
4699782	4699805	20	+	28162770	EOL1	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	-0.08393869431729373	[681]	[338]	0	hSpCas9	negative selection	11402955
4699261	4699284	20	-	28162770	EOL1	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	0.7035485855339529	[344]	[295]	6	hSpCas9	negative selection	11402956
4699932	4699955	20	-	28162770	EOL1	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-0.9379487046795305	[79]	[21]	-6	hSpCas9	negative selection	11402957
4699287	4699310	20	+	28162770	EOL1	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	1.6044355297119322	[396]	[635]	9	hSpCas9	negative selection	11402958
4699448	4699471	20	-	28162770	EOL1	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	-0.5566589633871131	[750]	[268]	-4	hSpCas9	negative selection	11402959
4699476	4699499	20	+	28162770	EOL1	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	0.6756344739813935	[365]	[307]	6	hSpCas9	negative selection	11402960
4699495	4699518	20	+	28162770	EOL1	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	-0.2407368429798684	[387]	[172]	-2	hSpCas9	negative selection	11402961
4699822	4699845	20	-	28162770	EOL1	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	1.3620926702589482	[476]	[645]	9	hSpCas9	negative selection	11402962
4699859	4699882	20	+	28162770	EOL1	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	0.22520724970424566	[163]	[100]	2	hSpCas9	negative selection	11402963
4699229	4699252	20	-	28162770	EOL1	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	-0.10621448220015256	[236]	[115]	-1	hSpCas9	negative selection	11402964
4699782	4699805	20	+	28162770	MOLM13	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	-0.8440546247701615	[503]	[202]	-5	hSpCas9	negative selection	11572321
4699261	4699284	20	-	28162770	MOLM13	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	-0.4073841384224487	[298]	[162]	-2	hSpCas9	negative selection	11572322
4699932	4699955	20	-	28162770	MOLM13	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-3.6475878358753566	[51]	[2]	-9	hSpCas9	negative selection	11572323
4699287	4699310	20	+	28162770	MOLM13	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.6697373083041893	[292]	[336]	5	hSpCas9	negative selection	11572324
4699448	4699471	20	-	28162770	MOLM13	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	0.42297695966900417	[521]	[505]	3	hSpCas9	negative selection	11572325
4699476	4699499	20	+	28162770	MOLM13	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-3.7698782656787855	[282]	[14]	-9	hSpCas9	negative selection	11572326
4699495	4699518	20	+	28162770	MOLM13	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.18702168262346663	[406]	[334]	1	hSpCas9	negative selection	11572327
4699822	4699845	20	-	28162770	MOLM13	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-2.07507903051195	[710]	[121]	-7	hSpCas9	negative selection	11572328
4699859	4699882	20	+	28162770	MOLM13	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-2.53993012291472	[369]	[45]	-8	hSpCas9	negative selection	11572329
4699229	4699252	20	-	28162770	MOLM13	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	-0.16380416952156854	[250]	[161]	-1	hSpCas9	negative selection	11572330
4699782	4699805	20	+	28162770	HEL	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	0.15510351600865313	[522]	[372]	1	hSpCas9	negative selection	11741687
4699261	4699284	20	-	28162770	HEL	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	-0.4806435835049252	[304]	[139]	-3	hSpCas9	negative selection	11741688
4699932	4699955	20	-	28162770	HEL	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-2.1646160900572475	[62]	[8]	-8	hSpCas9	negative selection	11741689
4699287	4699310	20	+	28162770	HEL	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.2146451798960669	[295]	[219]	1	hSpCas9	negative selection	11741690
4699448	4699471	20	-	28162770	HEL	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	0.37970442616656297	[509]	[424]	3	hSpCas9	negative selection	11741691
4699476	4699499	20	+	28162770	HEL	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-0.24803209824488454	[266]	[143]	-2	hSpCas9	negative selection	11741692
4699495	4699518	20	+	28162770	HEL	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.8857155854928973	[337]	[399]	7	hSpCas9	negative selection	11741693
4699822	4699845	20	-	28162770	HEL	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-1.1479373489106168	[601]	[173]	-6	hSpCas9	negative selection	11741694
4699859	4699882	20	+	28162770	HEL	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	0.022586902816900734	[248]	[161]	0	hSpCas9	negative selection	11741695
4699229	4699252	20	-	28162770	HEL	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	-0.07069822666960839	[222]	[135]	0	hSpCas9	negative selection	11741696
4699782	4699805	20	+	28162770	MV411	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	0.4411399355082136	[340]	[389]	4	hSpCas9	negative selection	11911053
4699261	4699284	20	-	28162770	MV411	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	0.5593815570975156	[231]	[287]	5	hSpCas9	negative selection	11911054
4699932	4699955	20	-	28162770	MV411	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-1.4306343543298623	[31]	[9]	-7	hSpCas9	negative selection	11911055
4699287	4699310	20	+	28162770	MV411	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	-0.1111592541519838	[258]	[201]	-1	hSpCas9	negative selection	11911056
4699448	4699471	20	-	28162770	MV411	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	-0.42173795384146606	[387]	[243]	-3	hSpCas9	negative selection	11911057
4699476	4699499	20	+	28162770	MV411	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-0.19393409630953096	[257]	[189]	-1	hSpCas9	negative selection	11911058
4699495	4699518	20	+	28162770	MV411	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	-0.22619460240691674	[267]	[192]	-2	hSpCas9	negative selection	11911059
4699822	4699845	20	-	28162770	MV411	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.10832413918046246	[301]	[235]	-1	hSpCas9	negative selection	11911060
4699859	4699882	20	+	28162770	MV411	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-0.38191906929683417	[98]	[63]	-3	hSpCas9	negative selection	11911061
4699229	4699252	20	-	28162770	MV411	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.692078763106517	[204]	[278]	6	hSpCas9	negative selection	11911062
4699782	4699805	20	+	28162770	MONOMAC1	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	0.22798474079191233	[215]	[289]	2	hSpCas9	negative selection	12080419
4699261	4699284	20	-	28162770	MONOMAC1	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	-0.3164520140043244	[213]	[196]	-3	hSpCas9	negative selection	12080420
4699932	4699955	20	-	28162770	MONOMAC1	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-0.4507934393053368	[30]	[25]	-4	hSpCas9	negative selection	12080421
4699287	4699310	20	+	28162770	MONOMAC1	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.48103505805308394	[164]	[263]	5	hSpCas9	negative selection	12080422
4699448	4699471	20	-	28162770	MONOMAC1	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	0.2081046160767901	[255]	[338]	2	hSpCas9	negative selection	12080423
4699476	4699499	20	+	28162770	MONOMAC1	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-2.1085001724578967	[157]	[41]	-9	hSpCas9	negative selection	12080424
4699495	4699518	20	+	28162770	MONOMAC1	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.5116233778865068	[174]	[285]	5	hSpCas9	negative selection	12080425
4699822	4699845	20	-	28162770	MONOMAC1	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.07263501069638467	[252]	[304]	0	hSpCas9	negative selection	12080426
4699859	4699882	20	+	28162770	MONOMAC1	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-0.1739532339465124	[61]	[62]	-1	hSpCas9	negative selection	12080427
4699229	4699252	20	-	28162770	MONOMAC1	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.04912374020984395	[85]	[101]	0	hSpCas9	negative selection	12080428
4699782	4699805	20	+	28162770	OCIAML2	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	-0.08848420752069219	[60]	[317]	0	hSpCas9	negative selection	12249785
4699261	4699284	20	-	28162770	OCIAML2	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	0.4270715989116969	[41]	[312]	4	hSpCas9	negative selection	12249786
4699932	4699955	20	-	28162770	OCIAML2	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-3.3450989431583027	[10]	[5]	-9	hSpCas9	negative selection	12249787
4699287	4699310	20	+	28162770	OCIAML2	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.9216875975365989	[37]	[398]	8	hSpCas9	negative selection	12249788
4699448	4699471	20	-	28162770	OCIAML2	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	0.016247675796805527	[70]	[397]	0	hSpCas9	negative selection	12249789
4699476	4699499	20	+	28162770	OCIAML2	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-0.5744656362267011	[35]	[133]	-4	hSpCas9	negative selection	12249790
4699495	4699518	20	+	28162770	OCIAML2	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	0.13203467721245377	[53]	[327]	1	hSpCas9	negative selection	12249791
4699822	4699845	20	-	28162770	OCIAML2	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	0.3831995266149436	[47]	[346]	3	hSpCas9	negative selection	12249792
4699859	4699882	20	+	28162770	OCIAML2	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-0.20528525872116626	[25]	[124]	-2	hSpCas9	negative selection	12249793
4699229	4699252	20	-	28162770	OCIAML2	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	-0.682133930435873	[43]	[151]	-5	hSpCas9	negative selection	12249794
4699782	4699805	20	+	28162770	OCIAML3	viability	ACGGTCACCACAACCACCAAGGG	PRNP	ENSG00000171867	-0.09874794255123898	[93]	[264]	-1	hSpCas9	negative selection	12419151
4699261	4699284	20	-	28162770	OCIAML3	viability	GAGGCCCAGGTCACTCCATGTGG	PRNP	ENSG00000171867	0.070389327891398	[52]	[167]	0	hSpCas9	negative selection	12419152
4699932	4699955	20	-	28162770	OCIAML3	viability	GAGATCAGGAGGATCACAGGTGG	PRNP	ENSG00000171867	-3.5940076403241634	[11]	[2]	-9	hSpCas9	negative selection	12419153
4699287	4699310	20	+	28162770	OCIAML3	viability	AAGAAGCGCCCGAAGCCTGGAGG	PRNP	ENSG00000171867	0.39119535774775616	[48]	[193]	3	hSpCas9	negative selection	12419154
4699448	4699471	20	-	28162770	OCIAML3	viability	GCTGTCCCCAGCCACCACCATGG	PRNP	ENSG00000171867	0.27540824986569246	[103]	[379]	2	hSpCas9	negative selection	12419155
4699476	4699499	20	+	28162770	OCIAML3	viability	GGTGGTGGCTGGGGTCAAGGAGG	PRNP	ENSG00000171867	-0.8821330271207873	[57]	[94]	-6	hSpCas9	negative selection	12419156
4699495	4699518	20	+	28162770	OCIAML3	viability	GAGGTGGCACCCACAGTCAGTGG	PRNP	ENSG00000171867	-0.3690412753238891	[79]	[186]	-3	hSpCas9	negative selection	12419157
4699822	4699845	20	-	28162770	OCIAML3	viability	GCGCTCCATCATCTTAACGTCGG	PRNP	ENSG00000171867	-0.5012972665093893	[112]	[240]	-4	hSpCas9	negative selection	12419158
4699859	4699882	20	+	28162770	OCIAML3	viability	GTGTATCACCCAGTACGAGAGGG	PRNP	ENSG00000171867	-0.5665269039020562	[25]	[52]	-4	hSpCas9	negative selection	12419159
4699229	4699252	20	-	28162770	OCIAML3	viability	GAACCAGCATCCAGCAGCCAAGG	PRNP	ENSG00000171867	0.8150060713269105	[44]	[238]	7	hSpCas9	negative selection	12419160