Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 5663
• Symbol: PSEN1
• Description: presenilin 1

DataSource: http://genomecrispr.dkfz.de/#!/results/PSEN1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
73170889	73170912	14	+	26472758	Jiyoye	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.2912451689985667	[356]	[109]	-7	hSpCas9	negative selection	129428
73211933	73211956	14	-	26472758	Jiyoye	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	0.15083562824608804	[128]	[107]	1	hSpCas9	negative selection	129429
73170973	73170996	14	+	26472758	Jiyoye	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	0.5381606936818405	[241]	[264]	4	hSpCas9	negative selection	129430
73192815	73192838	14	-	26472758	Jiyoye	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	-0.27429510006862917	[169]	[105]	-2	hSpCas9	negative selection	129431
73211823	73211846	14	+	26472758	Jiyoye	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	0.53645839845084	[63]	[69]	4	hSpCas9	negative selection	129432
73217179	73217202	14	+	26472758	Jiyoye	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.19144669045043616	[251]	[216]	1	hSpCas9	negative selection	129433
73148038	73148061	14	-	26472758	Jiyoye	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	-0.19427524200385177	[87]	[57]	-1	hSpCas9	negative selection	129434
73170813	73170836	14	+	26472758	Jiyoye	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	-1.2173154834019204	[147]	[47]	-7	hSpCas9	negative selection	129435
73173671	73173694	14	-	26472758	Jiyoye	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.748791811315348	[130]	[165]	5	hSpCas9	negative selection	129436
73192796	73192819	14	-	26472758	Jiyoye	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	-0.8058183418283249	[101]	[43]	-5	hSpCas9	negative selection	129437
73170889	73170912	14	+	26472758	KBM7	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.3795202565219227	[1216,1218]	[207,232]	-7	hSpCas9	negative selection	320546
73211933	73211956	14	-	26472758	KBM7	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	0.43475284268634223	[334,384]	[296,172]	5	hSpCas9	negative selection	320547
73170973	73170996	14	+	26472758	KBM7	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	0.644757907239385	[1377,765]	[874,673]	7	hSpCas9	negative selection	320548
73192815	73192838	14	-	26472758	KBM7	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	0.7223687358604085	[540,535]	[436,403]	7	hSpCas9	negative selection	320549
73211823	73211846	14	+	26472758	KBM7	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	-1.5825597813555001	[410,260]	[64,39]	-8	hSpCas9	negative selection	320550
73217179	73217202	14	+	26472758	KBM7	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.26302988742689115	[1134,478]	[511,372]	2	hSpCas9	negative selection	320551
73148038	73148061	14	-	26472758	KBM7	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	0.21428300699714914	[372,414]	[308,134]	2	hSpCas9	negative selection	320552
73170813	73170836	14	+	26472758	KBM7	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	-0.15044820044706642	[300,337]	[130,141]	-1	hSpCas9	negative selection	320553
73173671	73173694	14	-	26472758	KBM7	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.3786857255273336	[472,406]	[263,271]	4	hSpCas9	negative selection	320554
73192796	73192819	14	-	26472758	KBM7	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	-0.02868238564174419	[195,259]	[104,108]	0	hSpCas9	negative selection	320555
73170889	73170912	14	+	26472758	Raji	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.8499120136721623	[465]	[29]	-8	hSpCas9	negative selection	511664
73211933	73211956	14	-	26472758	Raji	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	-0.1513507330265687	[200]	[41]	-1	hSpCas9	negative selection	511665
73170973	73170996	14	+	26472758	Raji	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	-0.1005093162677333	[461]	[99]	-1	hSpCas9	negative selection	511666
73192815	73192838	14	-	26472758	Raji	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	0.7675335324889747	[161]	[63]	7	hSpCas9	negative selection	511667
73211823	73211846	14	+	26472758	Raji	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	0.43669116062655944	[155]	[48]	4	hSpCas9	negative selection	511668
73217179	73217202	14	+	26472758	Raji	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.8865073464845316	[316]	[135]	7	hSpCas9	negative selection	511669
73148038	73148061	14	-	26472758	Raji	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	0.8178769181786146	[109]	[44]	7	hSpCas9	negative selection	511670
73170813	73170836	14	+	26472758	Raji	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	-0.39511680515558356	[237]	[41]	-3	hSpCas9	negative selection	511671
73173671	73173694	14	-	26472758	Raji	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.4399588744604702	[377]	[118]	4	hSpCas9	negative selection	511672
73192796	73192819	14	-	26472758	Raji	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	0.20049293976508087	[104]	[27]	2	hSpCas9	negative selection	511673
73170889	73170912	14	+	26472758	K562	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-4.241008099503794	[1007]	[44]	-9	hSpCas9	negative selection	702782
73211933	73211956	14	-	26472758	K562	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	-0.11917200619372076	[403]	[313]	-1	hSpCas9	negative selection	702783
73170973	73170996	14	+	26472758	K562	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	0.9839411590829943	[901]	[1505]	8	hSpCas9	negative selection	702784
73192815	73192838	14	-	26472758	K562	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	1.2043412882911118	[437]	[851]	8	hSpCas9	negative selection	702785
73211823	73211846	14	+	26472758	K562	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	-2.760875572003066	[272]	[33]	-8	hSpCas9	negative selection	702786
73217179	73217202	14	+	26472758	K562	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.9048783359255494	[545]	[862]	7	hSpCas9	negative selection	702787
73148038	73148061	14	-	26472758	K562	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	0.12790471894002164	[347]	[320]	0	hSpCas9	negative selection	702788
73170813	73170836	14	+	26472758	K562	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	0.5795523613530768	[347]	[438]	5	hSpCas9	negative selection	702789
73173671	73173694	14	-	26472758	K562	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.5309816689964815	[445]	[543]	4	hSpCas9	negative selection	702790
73192796	73192819	14	-	26472758	K562	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	1.1102820550149106	[106]	[194]	8	hSpCas9	negative selection	702791
73148079	73148102	14	-	26627737	DLD1	viability	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	0.36787828601286066	[161]	[37,126,37]	4	hSpCas9	negative selection	789263
73170796	73170819	14	+	26627737	DLD1	viability	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	2.696838941334484	[36]	[28,104,89]	9	hSpCas9	negative selection	789264
73173736	73173759	14	-	26627737	DLD1	viability	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	0.19583070808237757	[133]	[64,40,38]	2	hSpCas9	negative selection	789265
73192779	73192802	14	+	26627737	DLD1	viability	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	-0.21059709321694256	[482]	[155,177,68]	-2	hSpCas9	negative selection	789266
73206397	73206420	14	+	26627737	DLD1	viability	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	0.15221745620816451	[326]	[68,195,83]	1	hSpCas9	negative selection	789267
73211811	73211834	14	+	26627737	DLD1	viability	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	-0.23024643754516083	[491]	[124,69,186]	-2	hSpCas9	negative selection	789268
73148079	73148102	14	-	26627737	GBM cells	viability after 5 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.647368157671411	[183]	[51,73]	-8	hSpCas9	negative selection	871578
73170796	73170819	14	+	26627737	GBM cells	viability after 5 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-0.2530892185593643	[79]	[23,47]	-4	hSpCas9	negative selection	871579
73173736	73173759	14	-	26627737	GBM cells	viability after 5 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	0.37021959381127467	[175]	[106,136]	5	hSpCas9	negative selection	871580
73192779	73192802	14	+	26627737	GBM cells	viability after 5 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	-0.006449250976239496	[117]	[71,53]	0	hSpCas9	negative selection	871581
73206397	73206420	14	+	26627737	GBM cells	viability after 5 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	0.2760714904934402	[163]	[122,89]	4	hSpCas9	negative selection	871582
73211811	73211834	14	+	26627737	GBM cells	viability after 5 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.08985665759708095	[105]	[73,46]	1	hSpCas9	negative selection	871583
73148079	73148102	14	-	26627737	GBM cells	viability after 13 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.6770330178235271	[183]	[46,74]	-7	hSpCas9	negative selection	953893
73170796	73170819	14	+	26627737	GBM cells	viability after 13 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-0.14277385116063623	[79]	[51,28]	-2	hSpCas9	negative selection	953894
73173736	73173759	14	-	26627737	GBM cells	viability after 13 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	0.2896776351250636	[175]	[124,109]	3	hSpCas9	negative selection	953895
73192779	73192802	14	+	26627737	GBM cells	viability after 13 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.5403288476451117	[117]	[107,80]	6	hSpCas9	negative selection	953896
73206397	73206420	14	+	26627737	GBM cells	viability after 13 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	0.5126509914507734	[163]	[164,95]	6	hSpCas9	negative selection	953897
73211811	73211834	14	+	26627737	GBM cells	viability after 13 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.06548652912642439	[105]	[84,39]	0	hSpCas9	negative selection	953898
73148079	73148102	14	-	26627737	GBM cells	viability after 21 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	0.2920001218172162	[183]	[124,119]	3	hSpCas9	negative selection	1036208
73170796	73170819	14	+	26627737	GBM cells	viability after 21 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	0.13657305287544386	[79]	[52,42]	1	hSpCas9	negative selection	1036209
73173736	73173759	14	-	26627737	GBM cells	viability after 21 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	0.6826876520118662	[175]	[153,152]	7	hSpCas9	negative selection	1036210
73192779	73192802	14	+	26627737	GBM cells	viability after 21 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.5461981248807256	[117]	[90,95]	5	hSpCas9	negative selection	1036211
73206397	73206420	14	+	26627737	GBM cells	viability after 21 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	0.3499357744928838	[163]	[123,103]	3	hSpCas9	negative selection	1036212
73211811	73211834	14	+	26627737	GBM cells	viability after 21 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	-0.2355968213856583	[105]	[50,46]	-2	hSpCas9	negative selection	1036213
73148079	73148102	14	-	26627737	RPE1	viability after 9 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.5668687461389089	[532]	[123,97]	-4	hSpCas9	negative selection	1118523
73170796	73170819	14	+	26627737	RPE1	viability after 9 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	1.0103012908269258	[163]	[95,112]	6	hSpCas9	negative selection	1118524
73173736	73173759	14	-	26627737	RPE1	viability after 9 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	0.775771214996789	[229]	[138,102]	5	hSpCas9	negative selection	1118525
73192779	73192802	14	+	26627737	RPE1	viability after 9 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	-1.0924607915355942	[407]	[72,42]	-7	hSpCas9	negative selection	1118526
73206397	73206420	14	+	26627737	RPE1	viability after 9 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-0.41554496368402266	[626]	[106,198]	-3	hSpCas9	negative selection	1118527
73211811	73211834	14	+	26627737	RPE1	viability after 9 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.4990332822750831	[830]	[454,254]	3	hSpCas9	negative selection	1118528
73148079	73148102	14	-	26627737	RPE1	viability after 12 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.3149572378824058	[532]	[118,110]	-2	hSpCas9	negative selection	1200838
73170796	73170819	14	+	26627737	RPE1	viability after 12 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-0.23868018409447922	[163]	[31,42]	-2	hSpCas9	negative selection	1200839
73173736	73173759	14	-	26627737	RPE1	viability after 12 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	1.0001562937457749	[229]	[177,65]	6	hSpCas9	negative selection	1200840
73192779	73192802	14	+	26627737	RPE1	viability after 12 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	-0.24026103005814803	[407]	[119,63]	-2	hSpCas9	negative selection	1200841
73206397	73206420	14	+	26627737	RPE1	viability after 12 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-0.7498829573143295	[626]	[71,129]	-5	hSpCas9	negative selection	1200842
73211811	73211834	14	+	26627737	RPE1	viability after 12 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	-0.0007694390128317186	[830]	[312,127]	0	hSpCas9	negative selection	1200843
73148079	73148102	14	-	26627737	RPE1	viability after 15 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.07286069331174083	[532]	[179,107]	0	hSpCas9	negative selection	1283153
73170796	73170819	14	+	26627737	RPE1	viability after 15 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-0.6159151946087973	[163]	[14,44]	-4	hSpCas9	negative selection	1283154
73173736	73173759	14	-	26627737	RPE1	viability after 15 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	0.8335643463107711	[229]	[118,112]	5	hSpCas9	negative selection	1283155
73192779	73192802	14	+	26627737	RPE1	viability after 15 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	-0.9684760650681139	[407]	[59,57]	-6	hSpCas9	negative selection	1283156
73206397	73206420	14	+	26627737	RPE1	viability after 15 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	0.2047935976597135	[626]	[180,226]	1	hSpCas9	negative selection	1283157
73211811	73211834	14	+	26627737	RPE1	viability after 15 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.8291065205196451	[830]	[719,125]	5	hSpCas9	negative selection	1283158
73148079	73148102	14	-	26627737	RPE1	viability after 18 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	0.019485929600570495	[532]	[168,120]	0	hSpCas9	negative selection	1365468
73170796	73170819	14	+	26627737	RPE1	viability after 18 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-0.4197649370980212	[163]	[20,45]	-3	hSpCas9	negative selection	1365469
73173736	73173759	14	-	26627737	RPE1	viability after 18 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	0.6732585434993372	[229]	[112,83]	4	hSpCas9	negative selection	1365470
73192779	73192802	14	+	26627737	RPE1	viability after 18 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	-0.9670019877481411	[407]	[94,14]	-6	hSpCas9	negative selection	1365471
73206397	73206420	14	+	26627737	RPE1	viability after 18 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-0.07343623268896876	[626]	[96,228]	0	hSpCas9	negative selection	1365472
73211811	73211834	14	+	26627737	RPE1	viability after 18 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.24981454789320112	[830]	[314,214]	1	hSpCas9	negative selection	1365473
73148079	73148102	14	-	26627737	HeLa	viability after 8 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.6957611712882947	[364]	[137,111,55]	-6	hSpCas9	negative selection	1447783
73170796	73170819	14	+	26627737	HeLa	viability after 8 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	0.8862180756768325	[131]	[66,108,131]	7	hSpCas9	negative selection	1447784
73173736	73173759	14	-	26627737	HeLa	viability after 8 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	1.8329514342369575	[74]	[153,25,172]	9	hSpCas9	negative selection	1447785
73192779	73192802	14	+	26627737	HeLa	viability after 8 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	1.8074005419340404	[48]	[152,55,34]	9	hSpCas9	negative selection	1447786
73206397	73206420	14	+	26627737	HeLa	viability after 8 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-0.9424117734970283	[494]	[148,62,130]	-7	hSpCas9	negative selection	1447787
73211811	73211834	14	+	26627737	HeLa	viability after 8 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.4073305115463647	[435]	[331,195,244]	4	hSpCas9	negative selection	1447788
73148079	73148102	14	-	26627737	HeLa	viability after 12 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-1.0703250736080026	[364]	[60,82,69]	-7	hSpCas9	negative selection	1530098
73170796	73170819	14	+	26627737	HeLa	viability after 12 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	0.8971106408618397	[131]	[269,22,24]	7	hSpCas9	negative selection	1530099
73173736	73173759	14	-	26627737	HeLa	viability after 12 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	1.2741536349917644	[74]	[92,59,73]	8	hSpCas9	negative selection	1530100
73192779	73192802	14	+	26627737	HeLa	viability after 12 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	1.2790385928211474	[48]	[35,58,50]	8	hSpCas9	negative selection	1530101
73206397	73206420	14	+	26627737	HeLa	viability after 12 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-1.1518959645956002	[494]	[25,103,142]	-8	hSpCas9	negative selection	1530102
73211811	73211834	14	+	26627737	HeLa	viability after 12 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.575204859844958	[435]	[375,206,231]	5	hSpCas9	negative selection	1530103
73148079	73148102	14	-	26627737	HeLa	viability after 15 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.4194848155113331	[364]	[160,140,23]	-4	hSpCas9	negative selection	1612413
73170796	73170819	14	+	26627737	HeLa	viability after 15 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-0.10089623589456487	[131]	[105,36,2]	-1	hSpCas9	negative selection	1612414
73173736	73173759	14	-	26627737	HeLa	viability after 15 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	1.642697251198574	[74]	[57,114,114]	9	hSpCas9	negative selection	1612415
73192779	73192802	14	+	26627737	HeLa	viability after 15 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	2.11772970848154	[48]	[43,120,95]	9	hSpCas9	negative selection	1612416
73206397	73206420	14	+	26627737	HeLa	viability after 15 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-0.2796953230731396	[494]	[263,123,103]	-2	hSpCas9	negative selection	1612417
73211811	73211834	14	+	26627737	HeLa	viability after 15 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.05940618321674537	[435]	[237,48,273]	0	hSpCas9	negative selection	1612418
73148079	73148102	14	-	26627737	HeLa	viability after 18 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.48662645668318427	[364]	[101,111,23]	-4	hSpCas9	negative selection	1694728
73170796	73170819	14	+	26627737	HeLa	viability after 18 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-0.006815281292329001	[131]	[78,28,2]	0	hSpCas9	negative selection	1694729
73173736	73173759	14	-	26627737	HeLa	viability after 18 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	1.643517969068362	[74]	[43,88,114]	9	hSpCas9	negative selection	1694730
73192779	73192802	14	+	26627737	HeLa	viability after 18 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	2.0611609970781988	[48]	[27,93,95]	9	hSpCas9	negative selection	1694731
73206397	73206420	14	+	26627737	HeLa	viability after 18 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-0.23862467019141387	[494]	[186,101,103]	-2	hSpCas9	negative selection	1694732
73211811	73211834	14	+	26627737	HeLa	viability after 18 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.045104278619172766	[435]	[154,41,273]	0	hSpCas9	negative selection	1694733
73148079	73148102	14	-	26627737	HCT116	viability after 6 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.30193606673650275	[450]	[52,59]	-2	hSpCas9	negative selection	1777043
73170796	73170819	14	+	26627737	HCT116	viability after 6 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-1.6693692946972052	[209]	[1,14]	-7	hSpCas9	negative selection	1777044
73173736	73173759	14	-	26627737	HCT116	viability after 6 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	0.8858873349705758	[502]	[71,186]	5	hSpCas9	negative selection	1777045
73192779	73192802	14	+	26627737	HCT116	viability after 6 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	1.9848102164029657	[207]	[238,68]	8	hSpCas9	negative selection	1777046
73206397	73206420	14	+	26627737	HCT116	viability after 6 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-0.5363240078021061	[468]	[84,31]	-3	hSpCas9	negative selection	1777047
73211811	73211834	14	+	26627737	HCT116	viability after 6 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.5888607766358003	[786]	[207,173]	3	hSpCas9	negative selection	1777048
73148079	73148102	14	-	26627737	HCT116	viability after 8 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	0.7280556370229312	[139]	[118,120,142]	7	hSpCas9	negative selection	1859358
73170796	73170819	14	+	26627737	HCT116	viability after 8 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	1.1679840786237496	[49]	[46,38,98]	8	hSpCas9	negative selection	1859359
73173736	73173759	14	-	26627737	HCT116	viability after 8 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	-0.22134035140960945	[226]	[124,73,122]	-3	hSpCas9	negative selection	1859360
73192779	73192802	14	+	26627737	HCT116	viability after 8 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.5418347078285821	[47]	[56,32,25]	5	hSpCas9	negative selection	1859361
73206397	73206420	14	+	26627737	HCT116	viability after 8 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	0.9187182642522173	[149]	[188,95,183]	8	hSpCas9	negative selection	1859362
73211811	73211834	14	+	26627737	HCT116	viability after 8 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	-0.1037083568795405	[486]	[253,221,272]	-1	hSpCas9	negative selection	1859363
73148079	73148102	14	-	26627737	HCT116	viability after 9 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.6103534390710721	[450]	[79,77]	-4	hSpCas9	negative selection	1941673
73170796	73170819	14	+	26627737	HCT116	viability after 9 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	1.1090703544129747	[209]	[25,195]	7	hSpCas9	negative selection	1941674
73173736	73173759	14	-	26627737	HCT116	viability after 9 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	0.4219227806018393	[502]	[356,39]	3	hSpCas9	negative selection	1941675
73192779	73192802	14	+	26627737	HCT116	viability after 9 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.22451641581384307	[207]	[84,48]	1	hSpCas9	negative selection	1941676
73206397	73206420	14	+	26627737	HCT116	viability after 9 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	1.009547511290218	[468]	[269,237]	7	hSpCas9	negative selection	1941677
73211811	73211834	14	+	26627737	HCT116	viability after 9 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.153078119135449	[786]	[336,151]	1	hSpCas9	negative selection	1941678
73148079	73148102	14	-	26627737	HCT116	viability after 12 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	0.8228005310900838	[139]	[104,62,222]	7	hSpCas9	negative selection	2023988
73170796	73170819	14	+	26627737	HCT116	viability after 12 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	0.8271897029698423	[49]	[50,26,60]	7	hSpCas9	negative selection	2023989
73173736	73173759	14	-	26627737	HCT116	viability after 12 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	-0.826041903098796	[226]	[52,61,87]	-7	hSpCas9	negative selection	2023990
73192779	73192802	14	+	26627737	HCT116	viability after 12 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	1.0034878137038556	[47]	[54,36,58]	8	hSpCas9	negative selection	2023991
73206397	73206420	14	+	26627737	HCT116	viability after 12 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	1.2057774872770266	[149]	[94,135,320]	8	hSpCas9	negative selection	2023992
73211811	73211834	14	+	26627737	HCT116	viability after 12 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.09585829369551935	[486]	[146,328,356]	1	hSpCas9	negative selection	2023993
73148079	73148102	14	-	26627737	HCT116	viability after 15 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	0.6633825251442682	[139]	[188,29,169]	6	hSpCas9	negative selection	2106303
73170796	73170819	14	+	26627737	HCT116	viability after 15 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	0.11292661732874087	[49]	[53,14,26]	1	hSpCas9	negative selection	2106304
73173736	73173759	14	-	26627737	HCT116	viability after 15 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	-0.886138953246838	[226]	[110,73,31]	-7	hSpCas9	negative selection	2106305
73192779	73192802	14	+	26627737	HCT116	viability after 15 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	1.1561843561135066	[47]	[75,41,67]	8	hSpCas9	negative selection	2106306
73206397	73206420	14	+	26627737	HCT116	viability after 15 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	0.9210995903476976	[149]	[125,125,231]	7	hSpCas9	negative selection	2106307
73211811	73211834	14	+	26627737	HCT116	viability after 15 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.1518758868558835	[486]	[214,266,436]	1	hSpCas9	negative selection	2106308
73148079	73148102	14	-	26627737	HCT116	viability after 18 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	0.8818549798515427	[139]	[182,67,126]	7	hSpCas9	negative selection	2188618
73170796	73170819	14	+	26627737	HCT116	viability after 18 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	1.2271321143012452	[49]	[57,53,57]	8	hSpCas9	negative selection	2188619
73173736	73173759	14	-	26627737	HCT116	viability after 18 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	-0.7363585402818265	[226]	[34,100,58]	-6	hSpCas9	negative selection	2188620
73192779	73192802	14	+	26627737	HCT116	viability after 18 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	2.1960210548657737	[47]	[133,34,156]	9	hSpCas9	negative selection	2188621
73206397	73206420	14	+	26627737	HCT116	viability after 18 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	0.8778042122763001	[149]	[140,110,149]	7	hSpCas9	negative selection	2188622
73211811	73211834	14	+	26627737	HCT116	viability after 18 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.10939978860888733	[486]	[238,139,396]	1	hSpCas9	negative selection	2188623
73148017	73148040	14	-	24336569	HL60	viability	GGTGCAGGTAACTCTGTCATTGG	PSEN1	ENSG00000080815	-0.42677619059266514	[551]	[868]	-4	hSpCas9	negative selection	2286892
73148032	73148055	14	-	24336569	HL60	viability	TGGAAGTAGGACAACGGTGCAGG	PSEN1	ENSG00000080815	0.21834469466505502	[906]	[2232]	2	hSpCas9	negative selection	2286893
73148038	73148061	14	-	24336569	HL60	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	1.962930018729557	[179]	[1484]	9	hSpCas9	negative selection	2286894
73148045	73148068	14	-	24336569	HL60	viability	CATCTGTGCATTCTGGAAGTAGG	PSEN1	ENSG00000080815	0.18207219946666098	[478]	[1149]	1	hSpCas9	negative selection	2286895
73148052	73148075	14	+	24336569	HL60	viability	CCAGAATGCACAGATGTCTGAGG	PSEN1	ENSG00000080815	0.08826468251445485	[816]	[1837]	0	hSpCas9	negative selection	2286896
73148079	73148102	14	-	24336569	HL60	viability	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.22256938773395973	[761]	[1381]	-2	hSpCas9	negative selection	2286897
73170792	73170815	14	+	24336569	HL60	viability	TATAGAATGACAATAGAGAACGG	PSEN1	ENSG00000080815	-0.9373231249568167	[275]	[304]	-7	hSpCas9	negative selection	2286898
73170813	73170836	14	+	24336569	HL60	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	-0.609615679959195	[609]	[845]	-5	hSpCas9	negative selection	2286899
73170821	73170844	14	+	24336569	HL60	viability	CACAACGACAGACGGAGCCTTGG	PSEN1	ENSG00000080815	0.6514508730732257	[641]	[2133]	5	hSpCas9	negative selection	2286900
73170838	73170861	14	-	24336569	HL60	viability	ATAATGGCTCAGGGTGGCCAAGG	PSEN1	ENSG00000080815	0.5525720403905836	[683]	[2122]	5	hSpCas9	negative selection	2286901
73148017	73148040	14	-	24336569	KBM7	viability	GGTGCAGGTAACTCTGTCATTGG	PSEN1	ENSG00000080815	-1.1038329914558294	[419]	[532]	-7	hSpCas9	negative selection	2354069
73148032	73148055	14	-	24336569	KBM7	viability	TGGAAGTAGGACAACGGTGCAGG	PSEN1	ENSG00000080815	0.16604706242441725	[896]	[2744]	1	hSpCas9	negative selection	2354070
73148038	73148061	14	-	24336569	KBM7	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	-0.28211384329727	[287]	[645]	-2	hSpCas9	negative selection	2354071
73148045	73148068	14	-	24336569	KBM7	viability	CATCTGTGCATTCTGGAAGTAGG	PSEN1	ENSG00000080815	0.24656511506073062	[317]	[1028]	2	hSpCas9	negative selection	2354072
73148052	73148075	14	+	24336569	KBM7	viability	CCAGAATGCACAGATGTCTGAGG	PSEN1	ENSG00000080815	0.7942117910927509	[495]	[2345]	7	hSpCas9	negative selection	2354073
73148079	73148102	14	-	24336569	KBM7	viability	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	0.1383204234263271	[512]	[1539]	1	hSpCas9	negative selection	2354074
73170792	73170815	14	+	24336569	KBM7	viability	TATAGAATGACAATAGAGAACGG	PSEN1	ENSG00000080815	0.067891639925447	[240]	[688]	0	hSpCas9	negative selection	2354075
73170813	73170836	14	+	24336569	KBM7	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	-0.05737355024997437	[585]	[1535]	0	hSpCas9	negative selection	2354076
73170821	73170844	14	+	24336569	KBM7	viability	CACAACGACAGACGGAGCCTTGG	PSEN1	ENSG00000080815	0.4352881698531196	[653]	[2411]	4	hSpCas9	negative selection	2354077
73170838	73170861	14	-	24336569	KBM7	viability	ATAATGGCTCAGGGTGGCCAAGG	PSEN1	ENSG00000080815	-0.7333336788827596	[767]	[1259]	-5	hSpCas9	negative selection	2354078
73205434	73205457	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATGCCACTGTACTCCAGCCTGGG	PSEN1	ENSG00000080815	-1.9834711090057278	[190,159]	[9,8]	-9	dCas9-VP64	positive selection	2385595
73185369	73185392	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	CGAGGCTGGTGGATCACTTGCGG	PSEN1	ENSG00000080815	-0.5004197159700593	[34,216]	[12,25]	-2	dCas9-VP64	positive selection	2392179
73137913	73137936	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	AAAAAATTAGCTGGGCGTGGGGG	PSEN1	ENSG00000080815	-0.197392713830993	[100,122]	[28,12]	-1	dCas9-VP64	positive selection	2433304
73181801	73181824	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCTCACTTTGTCAGTCAGGCTGG	PSEN1	ENSG00000080815	-1.5063523378780252	[92,140]	[8,8]	-8	dCas9-VP64	positive selection	2433834
73145872	73145895	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	TGAGGTGGGTGGATCACTTGTGG	PSEN1	ENSG00000080815	0.9269503688862448	[9,0]	[1,1]	4	dCas9-VP64	positive selection	2463160
73147088	73147111	14	-	25494202	A375	resistance to PLX-4720 (puromycin)	AGGAGGCTGAGGCAGGAGAAAAG	PSEN1	ENSG00000080815	1.7244712313844854	[32,17]	[27,7]	6	dCas9-VP64	positive selection	2468513
73141819	73141842	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCACTTTGGGAGGCAGAGGCTGG	PSEN1	ENSG00000080815	1.3055372672802243	[104,28]	[48,21]	5	dCas9-VP64	positive selection	2470138
73205434	73205457	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATGCCACTGTACTCCAGCCTGGG	PSEN1	ENSG00000080815	-0.49457347436203747	[225,196]	[51,45]	-5	dCas9-VP64	positive selection	2480850
73185369	73185392	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	CGAGGCTGGTGGATCACTTGCGG	PSEN1	ENSG00000080815	3.8708272893405353	[79,171]	[9,1154]	9	dCas9-VP64	positive selection	2487434
73137913	73137936	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	AAAAAATTAGCTGGGCGTGGGGG	PSEN1	ENSG00000080815	-0.11251062881246372	[103,157]	[69,9]	-1	dCas9-VP64	positive selection	2528559
73181801	73181824	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCTCACTTTGTCAGTCAGGCTGG	PSEN1	ENSG00000080815	1.729933687670929	[231,166]	[375,68]	8	dCas9-VP64	positive selection	2529089
73145872	73145895	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	TGAGGTGGGTGGATCACTTGTGG	PSEN1	ENSG00000080815	-0.7008385215102662	[31,39]	[9,2]	-6	dCas9-VP64	positive selection	2558415
73147088	73147111	14	-	25494202	A375	resistance to PLX-4720 (zeocin)	AGGAGGCTGAGGCAGGAGAAAAG	PSEN1	ENSG00000080815	-0.1093774260535414	[64,117]	[17,35]	-1	dCas9-VP64	positive selection	2563768
73141819	73141842	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCACTTTGGGAGGCAGAGGCTGG	PSEN1	ENSG00000080815	4.207282944889167	[182,227]	[2502,59]	9	dCas9-VP64	positive selection	2565393
73173671	73173694	14	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	-0.28055836735252465	[3,3]	[3,1]	-4	hSpCas9	positive selection	3014217
73170970	73170993	14	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CCACCATGCAGAGAGTCACAGGG	PSEN1	ENSG00000080815	0.14700627555203297	[4,4]	[4,3]	3	hSpCas9	positive selection	3014218
73170793	73170816	14	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TATAGAATGACAATAGAGAACGG	PSEN1	ENSG00000080815	-0.08749993541129791	[2,2]	[2,1]	-1	hSpCas9	positive selection	3014219
73170858	73170881	14	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTATCTAATGGACGACCCCAGGG	PSEN1	ENSG00000080815	0.5874254908779613	[3,3]	[5,5]	9	hSpCas9	positive selection	3014220
73173671	73173694	14	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.6598934936895994	[3,3]	[2,5]	9	hSpCas9	positive selection	3082075
73170970	73170993	14	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CCACCATGCAGAGAGTCACAGGG	PSEN1	ENSG00000080815	-0.17018042417460416	[4,4]	[3,1]	-2	hSpCas9	positive selection	3082076
73170793	73170816	14	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TATAGAATGACAATAGAGAACGG	PSEN1	ENSG00000080815	0.27790100768546727	[2,2]	[2,2]	5	hSpCas9	positive selection	3082077
73170858	73170881	14	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTATCTAATGGACGACCCCAGGG	PSEN1	ENSG00000080815	-0.5940946792242372	[3,3]	[2,0]	-7	hSpCas9	positive selection	3082078
73170871	73170894		+	24336571	A375	resistance to PLX after 7 days	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.4887326113503604	[6,8]	[8,12]	9	hSpCas9	positive selection	3138292
73171030	73171053		-	24336571	A375	resistance to PLX after 7 days	CGTACAGCTGCCCATCCTTCCGG	PSEN1	ENSG00000080815	-0.09707888345298787	[53,48]	[48,46]	-3	hSpCas9	positive selection	3138294
73217195	73217218		-	24336571	A375	resistance to PLX after 7 days	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.1284563713736464	[26,26]	[23,24]	-4	hSpCas9	positive selection	3138295
73170871	73170894		+	24336571	A375	resistance to PLX after 14 days	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	2.0729231492551397	[13,4]	[17,19]	9	hSpCas9	positive selection	3196085
73171030	73171053		-	24336571	A375	resistance to PLX after 14 days	CGTACAGCTGCCCATCCTTCCGG	PSEN1	ENSG00000080815	-0.9034606599006192	[46,39]	[11,8]	-9	hSpCas9	positive selection	3196087
73217195	73217218		-	24336571	A375	resistance to PLX after 14 days	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-1.0000722779996776	[29,28]	[6,5]	-9	hSpCas9	positive selection	3196088
73170871	73170894		+	24336571	A375	viability after 7 days	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	-0.571260276288581	[12]	[6,8]	-7	hSpCas9	negative selection	3253878
73171030	73171053		-	24336571	A375	viability after 7 days	CGTACAGCTGCCCATCCTTCCGG	PSEN1	ENSG00000080815	0.34017152975864806	[42]	[53,48]	5	hSpCas9	negative selection	3253880
73217195	73217218		-	24336571	A375	viability after 7 days	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.03261800164421058	[28]	[26,26]	0	hSpCas9	negative selection	3253881
73170871	73170894		+	24336571	A375	viability after 14 days	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	-0.3060713323446131	[12]	[13,4]	-4	hSpCas9	negative selection	3311671
73171030	73171053		-	24336571	A375	viability after 14 days	CGTACAGCTGCCCATCCTTCCGG	PSEN1	ENSG00000080815	0.10477531679827368	[42]	[46,39]	1	hSpCas9	negative selection	3311673
73217195	73217218		-	24336571	A375	viability after 14 days	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.10648319700443554	[28]	[29,28]	1	hSpCas9	negative selection	3311674
73173656	73173679	14	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.21027933863716222	[176,176]	[0,0]	-1	hSpCas9	positive selection	3387894
73173576	73173599	14	-	27383988	293T	resistance to West Nile virus (flavivirus)	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	-0.40088527130595975	[201,201]	[0,0]	-3	hSpCas9	positive selection	3387895
73217195	73217218	14	-	27383988	293T	resistance to West Nile virus (flavivirus)	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.5108581133310913	[217,217]	[0,0]	-3	hSpCas9	positive selection	3387896
73173671	73173694	14	-	26780180	HT29	viability (Avana library 4 designs)	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	3.04492748764142	[]	[]	8	hSpCas9	negative selection	3452445
73170970	73170993	14	-	26780180	HT29	viability (Avana library 4 designs)	CCACCATGCAGAGAGTCACAGGG	PSEN1	ENSG00000080815	-0.118419441076051	[]	[]	-2	hSpCas9	negative selection	3452446
73170792	73170815	14	+	26780180	HT29	viability (Avana library 4 designs)	TATAGAATGACAATAGAGAACGG	PSEN1	ENSG00000080815	1.86025739343435	[]	[]	7	hSpCas9	negative selection	3452447
73170857	73170880	14	+	26780180	HT29	viability (Avana library 4 designs)	TTATCTAATGGACGACCCCAGGG	PSEN1	ENSG00000080815	1.18848734989569	[]	[]	4	hSpCas9	negative selection	3452448
73170857	73170880	14	+	26780180	A375	viability (Avana lentiCRISPRv2)	TTATCTAATGGACGACCCCAGGG	PSEN1	ENSG00000080815	0.845598377778421	[]	[]	1	hSpCas9	negative selection	3548824
73173671	73173694	14	-	26780180	A375	viability (Avana lentiCRISPRv2)	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	-4.55114195230443	[]	[]	-5	hSpCas9	negative selection	3548825
73170970	73170993	14	-	26780180	A375	viability (Avana lentiCRISPRv2)	CCACCATGCAGAGAGTCACAGGG	PSEN1	ENSG00000080815	3.98377923065612	[]	[]	6	hSpCas9	negative selection	3548826
73170792	73170815	14	+	26780180	A375	viability (Avana lentiCRISPRv2)	TATAGAATGACAATAGAGAACGG	PSEN1	ENSG00000080815	-17.0148840200965	[]	[]	-9	hSpCas9	negative selection	3548827
73170967	73170990	14	+	26780180	A375	viability (Avana lentiCRISPRv2)	TGTCCCTGTGACTCTCTGCATGG	PSEN1	ENSG00000080815	1.41818421766215	[]	[]	2	hSpCas9	negative selection	3548828
73170889	73170912	14	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	1.95599133804143	[]	[]	3	hSpCas9	negative selection	3548829
73170857	73170880	14	+	26780180	A375	viability (Avana lentiGuide)	TTATCTAATGGACGACCCCAGGG	PSEN1	ENSG00000080815	1.7050769809333	[]	[]	2	hSpCas9	negative selection	3657483
73173671	73173694	14	-	26780180	A375	viability (Avana lentiGuide)	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	-5.59453416254569	[]	[]	-8	hSpCas9	negative selection	3657484
73170970	73170993	14	-	26780180	A375	viability (Avana lentiGuide)	CCACCATGCAGAGAGTCACAGGG	PSEN1	ENSG00000080815	-0.925496503764735	[]	[]	-1	hSpCas9	negative selection	3657485
73170792	73170815	14	+	26780180	A375	viability (Avana lentiGuide)	TATAGAATGACAATAGAGAACGG	PSEN1	ENSG00000080815	-2.4433073241671	[]	[]	-4	hSpCas9	negative selection	3657486
73170967	73170990	14	+	26780180	A375	viability (Avana lentiGuide)	TGTCCCTGTGACTCTCTGCATGG	PSEN1	ENSG00000080815	-6.10082337320947	[]	[]	-9	hSpCas9	negative selection	3657487
73170889	73170912	14	+	26780180	A375	viability (Avana lentiGuide)	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	2.86626403205493	[]	[]	3	hSpCas9	negative selection	3657488
73170857	73170880	14	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTATCTAATGGACGACCCCAGGG	PSEN1	ENSG00000080815	-0.0686464468691638	[6]	[5,5]	-1	hSpCas9	positive selection	3766090
73173671	73173694	14	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	-0.6714550904924179	[5]	[2,3]	-7	hSpCas9	positive selection	3766091
73170970	73170993	14	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCACCATGCAGAGAGTCACAGGG	PSEN1	ENSG00000080815	0.11768441444879793	[5]	[6,4]	3	hSpCas9	positive selection	3766092
73170792	73170815	14	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TATAGAATGACAATAGAGAACGG	PSEN1	ENSG00000080815	-0.8187043583552166	[9]	[3,5]	-8	hSpCas9	positive selection	3766093
73170967	73170990	14	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGTCCCTGTGACTCTCTGCATGG	PSEN1	ENSG00000080815	0.2389320987969092	[5]	[6,6]	6	hSpCas9	positive selection	3766094
73170889	73170912	14	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-0.18488753769340732	[4]	[3,3]	-3	hSpCas9	positive selection	3766095
73170857	73170880	14	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTATCTAATGGACGACCCCAGGG	PSEN1	ENSG00000080815	0.1833954225567796	[5]	[5,5]	4	hSpCas9	positive selection	3874697
73173671	73173694	14	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	-0.09967061872568835	[5]	[4,3]	-1	hSpCas9	positive selection	3874698
73170970	73170993	14	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCACCATGCAGAGAGTCACAGGG	PSEN1	ENSG00000080815	0.1710645714424594	[6]	[5,5]	4	hSpCas9	positive selection	3874699
73170792	73170815	14	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TATAGAATGACAATAGAGAACGG	PSEN1	ENSG00000080815	-0.11411580311353833	[4]	[3,3]	-2	hSpCas9	positive selection	3874700
73170967	73170990	14	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGTCCCTGTGACTCTCTGCATGG	PSEN1	ENSG00000080815	0.23544651700052913	[5]	[5,6]	6	hSpCas9	positive selection	3874701
73170889	73170912	14	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-0.2278930961211075	[5]	[2,4]	-3	hSpCas9	positive selection	3874702
73217222	73217245	14	-	26780180	A375	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	1.85870936975197	[]	[]	9	hSpCas9	negative selection	3985134
73170871	73170894	14	+	26780180	A375	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	2.187259776292	[]	[]	9	hSpCas9	negative selection	3985135
73217195	73217218	14	-	26780180	A375	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.965994782043731	[]	[]	4	hSpCas9	negative selection	3985136
73173576	73173599	14	-	26780180	A375	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.394422056354259	[]	[]	0	hSpCas9	negative selection	3985137
73170854	73170877	14	-	26780180	A375	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.883171934110068	[]	[]	3	hSpCas9	negative selection	3985138
73173656	73173679	14	+	26780180	A375	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	1.16635767846212	[]	[]	6	hSpCas9	negative selection	3985139
73217222	73217245	14	-	26780180	HT29	viability (GeCKOv2 library)	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	3.31397332958548	[]	[]	9	hSpCas9	negative selection	4093100
73170871	73170894	14	+	26780180	HT29	viability (GeCKOv2 library)	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	2.46333020135372	[]	[]	9	hSpCas9	negative selection	4093101
73217195	73217218	14	-	26780180	HT29	viability (GeCKOv2 library)	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	1.39531866861653	[]	[]	7	hSpCas9	negative selection	4093102
73173576	73173599	14	-	26780180	HT29	viability (GeCKOv2 library)	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.930078137111827	[]	[]	4	hSpCas9	negative selection	4093103
73170854	73170877	14	-	26780180	HT29	viability (GeCKOv2 library)	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	1.18696097369156	[]	[]	6	hSpCas9	negative selection	4093104
73173656	73173679	14	+	26780180	HT29	viability (GeCKOv2 library)	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	2.20309731660589	[]	[]	9	hSpCas9	negative selection	4093105
73170871	73170894	14	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.6049417866718191	[2]	[2,4]	9	hSpCas9	positive selection	4163508
73171030	73171053	14	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGTACAGCTGCCCATCCTTCCGG	PSEN1	ENSG00000080815	-0.07139589293745519	[5]	[3,3]	-2	hSpCas9	positive selection	4163510
73217195	73217218	14	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.07680469183179828	[4]	[3,2]	-2	hSpCas9	positive selection	4163511
73170871	73170894	14	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	-0.0044401700224057095	[3]	[1,0,2,0]	0	hSpCas9	positive selection	4227530
73171030	73171053	14	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGTACAGCTGCCCATCCTTCCGG	PSEN1	ENSG00000080815	1.0839232937024088	[5]	[4,3,2,5]	7	hSpCas9	positive selection	4227532
73217195	73217218	14	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	1.0779540063791693	[4]	[4,3,1,4]	7	hSpCas9	positive selection	4227533
73170854	73170877	14	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.3077810246715683	[1]	[1,1]	6	hSpCas9	positive selection	4292657
73217222	73217245	14	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.5166291291862521	[3]	[2,1]	-8	hSpCas9	positive selection	4292658
73170871	73170894	14	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	-0.4652699141520208	[3]	[2,0]	-7	hSpCas9	positive selection	4292659
73173656	73173679	14	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.13911018702558375	[3]	[2,1]	-3	hSpCas9	positive selection	4356916
73173576	73173599	14	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.18330189527607155	[3]	[3,2]	3	hSpCas9	positive selection	4356917
73217195	73217218	14	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.6618355353911268	[3]	[7,2]	9	hSpCas9	positive selection	4356918
73170857	73170879	14	+	27760321	OCIAML3	viability	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	0.06437662865273983	[438,435]	[291,445]	0	hSpCas9	negative selection	4431271
73171020	73171042	14	+	27760321	OCIAML3	viability	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	0.3140682690480069	[367,270]	[289,330]	3	hSpCas9	negative selection	4431272
73173574	73173596	14	-	27760321	OCIAML3	viability	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	0.24659567334671692	[464,428]	[310,549]	3	hSpCas9	negative selection	4431273
73173657	73173679	14	+	27760321	OCIAML3	viability	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	0.10535085486309666	[454,359]	[308,381]	1	hSpCas9	negative selection	4431274
73192780	73192802	14	+	27760321	OCIAML3	viability	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.4358804772312488	[1008,864]	[907,1092]	5	hSpCas9	negative selection	4431275
73170857	73170879	14	+	27760321	OCIAML2	viability	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	0.07490038306965756	[438,435]	[325,436]	0	hSpCas9	negative selection	4514734
73171020	73171042	14	+	27760321	OCIAML2	viability	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	0.38098095924524195	[367,270]	[282,399]	5	hSpCas9	negative selection	4514735
73173574	73173596	14	-	27760321	OCIAML2	viability	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	0.10761064213453386	[464,428]	[301,504]	1	hSpCas9	negative selection	4514736
73173657	73173679	14	+	27760321	OCIAML2	viability	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.03915741139590523	[454,359]	[304,336]	0	hSpCas9	negative selection	4514737
73192780	73192802	14	+	27760321	OCIAML2	viability	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.4190917990049583	[1008,864]	[820,1259]	6	hSpCas9	negative selection	4514738
73170857	73170879	14	+	27760321	MV411	viability	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	1.2926419196259236	[438,435]	[692,733]	8	hSpCas9	negative selection	4598197
73171020	73171042	14	+	27760321	MV411	viability	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	1.1333722857026869	[367,270]	[305,686]	8	hSpCas9	negative selection	4598198
73173574	73173596	14	-	27760321	MV411	viability	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	1.3593835129911567	[464,428]	[1020,359]	8	hSpCas9	negative selection	4598199
73173657	73173679	14	+	27760321	MV411	viability	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	0.507494416779075	[454,359]	[468,245]	3	hSpCas9	negative selection	4598200
73192780	73192802	14	+	27760321	MV411	viability	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	1.229578580622241	[1008,864]	[1184,1836]	8	hSpCas9	negative selection	4598201
73170857	73170879	14	+	27760321	HL60	viability	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	-0.07440219731457129	[438,435]	[354,324]	-1	hSpCas9	negative selection	4681660
73171020	73171042	14	+	27760321	HL60	viability	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	0.1285796755440195	[367,270]	[305,257]	1	hSpCas9	negative selection	4681661
73173574	73173596	14	-	27760321	HL60	viability	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	0.03274555969074743	[464,428]	[456,284]	0	hSpCas9	negative selection	4681662
73173657	73173679	14	+	27760321	HL60	viability	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	0.19172292779797684	[454,359]	[337,419]	2	hSpCas9	negative selection	4681663
73192780	73192802	14	+	27760321	HL60	viability	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.48893016147898627	[1008,864]	[985,1160]	6	hSpCas9	negative selection	4681664
73170857	73170879	14	+	27760321	HT1080	viability	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	-1.8081413946239668	[435,339]	[46,40]	-6	hSpCas9	negative selection	4765123
73171020	73171042	14	+	27760321	HT1080	viability	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	-0.2537678222030242	[270,211]	[105,52]	-1	hSpCas9	negative selection	4765124
73173574	73173596	14	-	27760321	HT1080	viability	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	-1.320571811660929	[428,334]	[69,50]	-5	hSpCas9	negative selection	4765125
73173657	73173679	14	+	27760321	HT1080	viability	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	0.5967860788185828	[359,280]	[310,63]	3	hSpCas9	negative selection	4765126
73192780	73192802	14	+	27760321	HT1080	viability	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.5371387328805859	[864,674]	[594,280]	3	hSpCas9	negative selection	4765127
73170857	73170879	14	+	27760321	HT29	viability after 7 days	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	-0.4202259567277959	[435,339]	[273,465,363]	-6	hSpCas9	negative selection	4848586
73171020	73171042	14	+	27760321	HT29	viability after 7 days	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	0.04906993657542025	[270,211]	[456,275,251]	0	hSpCas9	negative selection	4848587
73173574	73173596	14	-	27760321	HT29	viability after 7 days	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	0.1492525068655897	[428,334]	[840,399,437]	2	hSpCas9	negative selection	4848588
73173657	73173679	14	+	27760321	HT29	viability after 7 days	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.046913361350276545	[359,280]	[630,256,342]	0	hSpCas9	negative selection	4848589
73192780	73192802	14	+	27760321	HT29	viability after 7 days	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.3435401993986591	[864,674]	[1304,1096,1367]	5	hSpCas9	negative selection	4848590
73170857	73170879	14	+	27760321	HT29	viability after 25 days	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	-0.525435153793071	[435,339]	[227,372,329]	-5	hSpCas9	negative selection	4932049
73171020	73171042	14	+	27760321	HT29	viability after 25 days	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	-0.4790167815521892	[270,211]	[184,199,210]	-4	hSpCas9	negative selection	4932050
73173574	73173596	14	-	27760321	HT29	viability after 25 days	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	-0.46292344194810675	[428,334]	[331,323,289]	-4	hSpCas9	negative selection	4932051
73173657	73173679	14	+	27760321	HT29	viability after 25 days	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.36286820639199835	[359,280]	[209,154,517]	-4	hSpCas9	negative selection	4932052
73192780	73192802	14	+	27760321	HT29	viability after 25 days	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	-0.33323210838825856	[864,674]	[732,515,859]	-3	hSpCas9	negative selection	4932053
73170857	73170879	14	+	27760321	HT29	viability after 22 days	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	-0.7219606042530549	[435,339]	[268,363,181]	-6	hSpCas9	negative selection	5015512
73171020	73171042	14	+	27760321	HT29	viability after 22 days	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	0.05401681437992556	[270,211]	[361,181,323]	0	hSpCas9	negative selection	5015513
73173574	73173596	14	-	27760321	HT29	viability after 22 days	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	-0.7764077126404665	[428,334]	[270,256,244]	-6	hSpCas9	negative selection	5015514
73173657	73173679	14	+	27760321	HT29	viability after 22 days	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.49263872928479313	[359,280]	[208,262,319]	-4	hSpCas9	negative selection	5015515
73192780	73192802	14	+	27760321	HT29	viability after 22 days	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	-0.11609901066811246	[864,674]	[630,815,1023]	-1	hSpCas9	negative selection	5015516
73170857	73170879	14	+	27760321	HT29	viability after 19 days	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	-1.2306509183303922	[435,339]	[235,172,163]	-7	hSpCas9	negative selection	5098975
73171020	73171042	14	+	27760321	HT29	viability after 19 days	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	0.10866365776144832	[270,211]	[259,240,384]	1	hSpCas9	negative selection	5098976
73173574	73173596	14	-	27760321	HT29	viability after 19 days	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	-1.0796259727490096	[428,334]	[318,138,174]	-6	hSpCas9	negative selection	5098977
73173657	73173679	14	+	27760321	HT29	viability after 19 days	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.49152928992511646	[359,280]	[423,192,184]	-4	hSpCas9	negative selection	5098978
73192780	73192802	14	+	27760321	HT29	viability after 19 days	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	-0.5612496802137754	[864,674]	[737,501,565]	-5	hSpCas9	negative selection	5098979
73170857	73170879	14	+	27760321	HT29	viability after 16 days	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	-0.7250887384827382	[435,339]	[302,245,242]	-6	hSpCas9	negative selection	5182438
73171020	73171042	14	+	27760321	HT29	viability after 16 days	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	-0.2369348852260178	[270,211]	[189,311,179]	-3	hSpCas9	negative selection	5182439
73173574	73173596	14	-	27760321	HT29	viability after 16 days	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	-0.3109245646388592	[428,334]	[323,367,338]	-3	hSpCas9	negative selection	5182440
73173657	73173679	14	+	27760321	HT29	viability after 16 days	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.7514357945900471	[359,280]	[110,263,252]	-6	hSpCas9	negative selection	5182441
73192780	73192802	14	+	27760321	HT29	viability after 16 days	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.11265691081005036	[864,674]	[1117,999,691]	1	hSpCas9	negative selection	5182442
73170857	73170879	14	+	27760321	HT29	viability after 13 days	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	-0.34437373652768966	[435,339]	[416,302,343]	-4	hSpCas9	negative selection	5265901
73171020	73171042	14	+	27760321	HT29	viability after 13 days	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	0.054996084847724336	[270,211]	[289,185,390]	0	hSpCas9	negative selection	5265902
73173574	73173596	14	-	27760321	HT29	viability after 13 days	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	-0.44407800885904003	[428,334]	[478,327,178]	-5	hSpCas9	negative selection	5265903
73173657	73173679	14	+	27760321	HT29	viability after 13 days	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.17275165914647078	[359,280]	[227,350,405]	-2	hSpCas9	negative selection	5265904
73192780	73192802	14	+	27760321	HT29	viability after 13 days	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	-0.0031664058175093768	[864,674]	[911,840,918]	0	hSpCas9	negative selection	5265905
73170857	73170879	14	+	27760321	HT29	viability after 10 days	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	-0.04472866768043793	[435,339]	[390,608,413]	0	hSpCas9	negative selection	5349364
73171020	73171042	14	+	27760321	HT29	viability after 10 days	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	0.07852855893272709	[270,211]	[303,519,140]	1	hSpCas9	negative selection	5349365
73173574	73173596	14	-	27760321	HT29	viability after 10 days	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	-0.18316159513071023	[428,334]	[600,434,228]	-2	hSpCas9	negative selection	5349366
73173657	73173679	14	+	27760321	HT29	viability after 10 days	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.17389271238619847	[359,280]	[254,396,411]	-2	hSpCas9	negative selection	5349367
73192780	73192802	14	+	27760321	HT29	viability after 10 days	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.181198461401755	[864,674]	[904,1033,1323]	2	hSpCas9	negative selection	5349368
73170857	73170879	14	+	27760321	MOLM13	viability	TTATCTAATGGACGACCCCAGG	PSEN1	ENSG00000080815	1.2813514714755547	[438,435]	[550,644]	8	hSpCas9	negative selection	5432827
73171020	73171042	14	+	27760321	MOLM13	viability	GCTTTTATACCCGGAAGGATGG	PSEN1	ENSG00000080815	1.1094170267437118	[367,270]	[393,377]	7	hSpCas9	negative selection	5432828
73173574	73173596	14	-	27760321	MOLM13	viability	TCGGTATCTTCTGTGAATGGGG	PSEN1	ENSG00000080815	-0.6117088570354323	[464,428]	[103,216]	-4	hSpCas9	negative selection	5432829
73173657	73173679	14	+	27760321	MOLM13	viability	GTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	0.8286107812582465	[454,359]	[314,482]	6	hSpCas9	negative selection	5432830
73192780	73192802	14	+	27760321	MOLM13	viability	ATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	1.1844877773852387	[1008,864]	[1205,1190]	8	hSpCas9	negative selection	5432831
73136468	73136491	14	+	27661255	K562	viability	GCCTGGGACAGGCAGCTCCGGGG	PSEN1	ENSG00000080815	-0.3764076531977003	[129,98]	[86,56]	-7	dCas9-KRAB	negative selection	5504764
73136534	73136557	14	+	27661255	K562	viability	GGAACCTGAGCTACGAGCCGCGG	PSEN1	ENSG00000080815	0.11148485370329053	[1397,1430]	[1332,1123]	4	dCas9-KRAB	negative selection	5504765
73136864	73136887	14	-	27661255	K562	viability	GTTCAGACGGCTACTAATCCCGG	PSEN1	ENSG00000080815	0.04722587930445543	[1148,1261]	[1022,967]	1	dCas9-KRAB	negative selection	5504766
73170854	73170877	14	-	27260156	BXPC3	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.044513310911713955	[101]	[85,152,86,82]	-1	hSpCas9	negative selection	5565117
73217222	73217245	14	-	27260156	BXPC3	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.1822977320584504	[745]	[513,673,721,878]	-4	hSpCas9	negative selection	5565118
73170871	73170894	14	+	27260156	BXPC3	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.2987123540688273	[503]	[594,550,706,761]	6	hSpCas9	negative selection	5565119
73173656	73173679	14	+	27260156	BXPC3	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.5505735205042599	[533]	[315,330,493,394]	-8	hSpCas9	negative selection	5629376
73173576	73173599	14	-	27260156	BXPC3	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.06137166663550403	[520]	[474,601,608,595]	1	hSpCas9	negative selection	5629377
73217195	73217218	14	-	27260156	BXPC3	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.24694749441408037	[507]	[382,381,494,551]	-5	hSpCas9	negative selection	5629378
73170854	73170877	14	-	27260156	A673	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.11422118857122232	[101]	[182,75,191,82]	2	hSpCas9	negative selection	5686368
73217222	73217245	14	-	27260156	A673	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.31708213288424303	[745]	[815,609,763,696]	-7	hSpCas9	negative selection	5686369
73170871	73170894	14	+	27260156	A673	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.13364927917018415	[503]	[690,693,551,723]	3	hSpCas9	negative selection	5686370
73173656	73173679	14	+	27260156	A673	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.27686212964842416	[533]	[604,461,505,554]	-6	hSpCas9	negative selection	5750627
73173576	73173599	14	-	27260156	A673	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.0768281299998132	[520]	[733,635,623,652]	1	hSpCas9	negative selection	5750628
73217195	73217218	14	-	27260156	A673	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.13145218099226086	[507]	[730,606,616,728]	3	hSpCas9	negative selection	5750629
73170854	73170877	14	-	27260156	A375	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.1164637071411736	[101]	[157,160,85,48]	-2	hSpCas9	negative selection	5807619
73217222	73217245	14	-	27260156	A375	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	0.05325829774768376	[745]	[760,1097,1182,629]	0	hSpCas9	negative selection	5807620
73170871	73170894	14	+	27260156	A375	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.26397515201272287	[503]	[858,712,624,637]	4	hSpCas9	negative selection	5807621
73173656	73173679	14	+	27260156	A375	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.31539847618744365	[533]	[750,337,464,435]	-4	hSpCas9	negative selection	5871878
73173576	73173599	14	-	27260156	A375	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.6511827719320462	[520]	[1005,855,1177,785]	8	hSpCas9	negative selection	5871879
73217195	73217218	14	-	27260156	A375	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.26246097283738545	[507]	[804,796,693,576]	4	hSpCas9	negative selection	5871880
73170854	73170877	14	-	27260156	COLO741	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.33342212277294503	[101]	[146,153,187]	7	hSpCas9	negative selection	5928870
73217222	73217245	14	-	27260156	COLO741	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.10914616561869162	[745]	[1093,694,877]	-2	hSpCas9	negative selection	5928871
73170871	73170894	14	+	27260156	COLO741	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.07680415833399305	[503]	[950,546,568]	1	hSpCas9	negative selection	5928872
73173656	73173679	14	+	27260156	COLO741	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.2698216333492409	[533]	[731,520,464]	-5	hSpCas9	negative selection	5993129
73173576	73173599	14	-	27260156	COLO741	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.3457295511336914	[520]	[853,660,1008]	7	hSpCas9	negative selection	5993130
73217195	73217218	14	-	27260156	COLO741	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.0688098809198015	[507]	[608,607,635]	-1	hSpCas9	negative selection	5993131
73170854	73170877	14	-	27260156	CAL120	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.16561189457935832	[101]	[240,120,80]	2	hSpCas9	negative selection	6050121
73217222	73217245	14	-	27260156	CAL120	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.286231946399807	[745]	[1003,779,539]	-4	hSpCas9	negative selection	6050122
73170871	73170894	14	+	27260156	CAL120	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.4592742678315863	[503]	[972,873,757]	7	hSpCas9	negative selection	6050123
73173656	73173679	14	+	27260156	CAL120	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.2605354700235382	[533]	[525,601,531]	-4	hSpCas9	negative selection	6114380
73173576	73173599	14	-	27260156	CAL120	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.026383695832065512	[520]	[681,704,597]	0	hSpCas9	negative selection	6114381
73217195	73217218	14	-	27260156	CAL120	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.07193817657379423	[507]	[425,606,741]	-1	hSpCas9	negative selection	6114382
73170854	73170877	14	-	27260156	CADOES1	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.6305611325925233	[101]	[56,39,62,85]	-8	hSpCas9	negative selection	6171372
73217222	73217245	14	-	27260156	CADOES1	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.14650980280282033	[745]	[713,490,490,817]	-3	hSpCas9	negative selection	6171373
73170871	73170894	14	+	27260156	CADOES1	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.13352190336527014	[503]	[498,494,619,439]	2	hSpCas9	negative selection	6171374
73173656	73173679	14	+	27260156	CADOES1	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.11894966753723973	[533]	[410,485,310,627]	-2	hSpCas9	negative selection	6235631
73173576	73173599	14	-	27260156	CADOES1	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.16899339412449935	[520]	[486,647,562,478]	3	hSpCas9	negative selection	6235632
73217195	73217218	14	-	27260156	CADOES1	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.14745834132845864	[507]	[622,458,509,499]	2	hSpCas9	negative selection	6235633
73170854	73170877	14	-	27260156	EWS502	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.21834097833107835	[101]	[44,112,69,151]	-4	hSpCas9	negative selection	6292623
73217222	73217245	14	-	27260156	EWS502	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.14572709092689196	[745]	[592,733,629,924]	-3	hSpCas9	negative selection	6292624
73170871	73170894	14	+	27260156	EWS502	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.37536744710681286	[503]	[639,633,546,972]	6	hSpCas9	negative selection	6292625
73173656	73173679	14	+	27260156	EWS502	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.21407909344843504	[533]	[514,381,478,579]	-4	hSpCas9	negative selection	6356882
73173576	73173599	14	-	27260156	EWS502	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.09446994631976999	[520]	[540,624,635,554]	1	hSpCas9	negative selection	6356883
73217195	73217218	14	-	27260156	EWS502	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.11819968463845269	[507]	[448,401,526,621]	-2	hSpCas9	negative selection	6356884
73170854	73170877	14	-	27260156	EW8	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.6467706807462044	[101]	[57,62,56,32]	-8	hSpCas9	negative selection	6413874
73217222	73217245	14	-	27260156	EW8	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.36254126462007014	[745]	[564,454,398,482]	-6	hSpCas9	negative selection	6413875
73170871	73170894	14	+	27260156	EW8	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.07731730278527439	[503]	[469,488,408,362]	1	hSpCas9	negative selection	6413876
73173656	73173679	14	+	27260156	EW8	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	0.2123158655829974	[533]	[351,406,779,400]	4	hSpCas9	negative selection	6478133
73173576	73173599	14	-	27260156	EW8	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	-0.0366476939918505	[520]	[420,324,373,531]	0	hSpCas9	negative selection	6478134
73217195	73217218	14	-	27260156	EW8	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.30665038097670144	[507]	[873,551,351,324]	5	hSpCas9	negative selection	6478135
73170854	73170877	14	-	27260156	CORL105	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.6036339165192026	[101]	[111,32,107,67]	-8	hSpCas9	negative selection	6535125
73217222	73217245	14	-	27260156	CORL105	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.22675759992322653	[745]	[680,626,931,773]	-4	hSpCas9	negative selection	6535126
73170871	73170894	14	+	27260156	CORL105	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.35289490751897157	[503]	[616,786,902,724]	6	hSpCas9	negative selection	6535127
73173656	73173679	14	+	27260156	CORL105	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.12465813791815555	[533]	[467,434,832,596]	-2	hSpCas9	negative selection	6599384
73173576	73173599	14	-	27260156	CORL105	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.04532073989680255	[520]	[611,662,715,538]	0	hSpCas9	negative selection	6599385
73217195	73217218	14	-	27260156	CORL105	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.40084575816972245	[507]	[490,323,555,450]	-6	hSpCas9	negative selection	6599386
73170854	73170877	14	-	27260156	HS294T	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.47778900885538533	[101]	[24,26,25,36]	-6	hSpCas9	negative selection	6656376
73217222	73217245	14	-	27260156	HS294T	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.6589299485688057	[745]	[147,193,168,229]	-7	hSpCas9	negative selection	6656377
73170871	73170894	14	+	27260156	HS294T	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.4483145664324144	[503]	[228,254,269,321]	6	hSpCas9	negative selection	6656378
73173656	73173679	14	+	27260156	HS294T	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	0.18777125457235697	[533]	[287,134,300,209]	2	hSpCas9	negative selection	6720635
73173576	73173599	14	-	27260156	HS294T	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.10420609284900026	[520]	[234,187,212,230]	1	hSpCas9	negative selection	6720636
73217195	73217218	14	-	27260156	HS294T	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.0864789156542299	[507]	[133,198,229,179]	-1	hSpCas9	negative selection	6720637
73170854	73170877	14	-	27260156	HCC44	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.09727311976899644	[101]	[106,92,97,131]	-2	hSpCas9	negative selection	6777627
73217222	73217245	14	-	27260156	HCC44	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.26580080159355235	[745]	[723,561,867,697]	-4	hSpCas9	negative selection	6777628
73170871	73170894	14	+	27260156	HCC44	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.09232848002983497	[503]	[398,717,737,559]	1	hSpCas9	negative selection	6777629
73173656	73173679	14	+	27260156	HCC44	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.29438930215202025	[533]	[442,501,587,444]	-5	hSpCas9	negative selection	6841886
73173576	73173599	14	-	27260156	HCC44	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.16842464556405937	[520]	[427,742,763,691]	2	hSpCas9	negative selection	6841887
73217195	73217218	14	-	27260156	HCC44	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.20769799642697967	[507]	[1025,432,653,601]	3	hSpCas9	negative selection	6841888
73170854	73170877	14	-	27260156	G402	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.7057382695426888	[101]	[197,45,47,30]	-7	hSpCas9	negative selection	6898878
73217222	73217245	14	-	27260156	G402	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.28184238446575344	[745]	[550,657,847,893]	-4	hSpCas9	negative selection	6898879
73170871	73170894	14	+	27260156	G402	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.12039981070409285	[503]	[717,293,831,805]	1	hSpCas9	negative selection	6898880
73173656	73173679	14	+	27260156	G402	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.5288516615531984	[533]	[387,500,533,378]	-6	hSpCas9	negative selection	6963137
73173576	73173599	14	-	27260156	G402	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.5554953554499732	[520]	[1801,657,684,708]	7	hSpCas9	negative selection	6963138
73217195	73217218	14	-	27260156	G402	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.045664852235080475	[507]	[530,619,582,797]	0	hSpCas9	negative selection	6963139
73170854	73170877	14	-	27260156	L33	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.3273917884776849	[101]	[95,37,45,62]	-6	hSpCas9	negative selection	7020129
73217222	73217245	14	-	27260156	L33	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.41733756282651513	[745]	[544,196,388,589]	-7	hSpCas9	negative selection	7020130
73170871	73170894	14	+	27260156	L33	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.21410875187746503	[503]	[568,248,407,513]	4	hSpCas9	negative selection	7020131
73173656	73173679	14	+	27260156	L33	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.3292373537479505	[533]	[416,184,203,505]	-6	hSpCas9	negative selection	7084388
73173576	73173599	14	-	27260156	L33	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	-0.021938933404973354	[520]	[399,211,336,600]	0	hSpCas9	negative selection	7084389
73217195	73217218	14	-	27260156	L33	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.059824264426427715	[507]	[468,185,306,537]	-1	hSpCas9	negative selection	7084390
73170854	73170877	14	-	27260156	K562	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.9990987006366019	[101]	[27,456,125,120]	9	hSpCas9	negative selection	7141380
73217222	73217245	14	-	27260156	K562	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.27962179830828	[745]	[669,428,658,437]	-3	hSpCas9	negative selection	7141381
73170871	73170894	14	+	27260156	K562	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.2613586857196115	[503]	[303,642,440,718]	3	hSpCas9	negative selection	7141382
73173656	73173679	14	+	27260156	K562	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.13013271753177003	[533]	[315,421,708,289]	-2	hSpCas9	negative selection	7205639
73173576	73173599	14	-	27260156	K562	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	-0.26949664774494897	[520]	[410,349,377,392]	-3	hSpCas9	negative selection	7205640
73217195	73217218	14	-	27260156	K562	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.07620353898422556	[507]	[241,517,748,383]	0	hSpCas9	negative selection	7205641
73170854	73170877	14	-	27260156	HT29	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.06268698072191725	[101]	[108,127,73,195]	1	hSpCas9	negative selection	7262631
73217222	73217245	14	-	27260156	HT29	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.15453618300928051	[745]	[784,900,935,655]	-3	hSpCas9	negative selection	7262632
73170871	73170894	14	+	27260156	HT29	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.25206174991631825	[503]	[764,829,666,669]	5	hSpCas9	negative selection	7262633
73173656	73173679	14	+	27260156	HT29	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.1735453516029702	[533]	[586,554,613,544]	-4	hSpCas9	negative selection	7326890
73173576	73173599	14	-	27260156	HT29	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.25437226347966746	[520]	[753,648,910,699]	5	hSpCas9	negative selection	7326891
73217195	73217218	14	-	27260156	HT29	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.12237077039988412	[507]	[588,674,641,391]	-3	hSpCas9	negative selection	7326892
73170854	73170877	14	-	27260156	MHHES1	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.21613739933461606	[101]	[149,80,215,90]	4	hSpCas9	negative selection	7383882
73217222	73217245	14	-	27260156	MHHES1	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.22119349766962443	[745]	[1092,567,687,579]	-4	hSpCas9	negative selection	7383883
73170871	73170894	14	+	27260156	MHHES1	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.2921891050826216	[503]	[804,739,662,596]	5	hSpCas9	negative selection	7383884
73173656	73173679	14	+	27260156	MHHES1	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.05953803655851758	[533]	[643,532,668,476]	-1	hSpCas9	negative selection	7448141
73173576	73173599	14	-	27260156	MHHES1	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.2950439528132742	[520]	[922,810,815,418]	5	hSpCas9	negative selection	7448142
73217195	73217218	14	-	27260156	MHHES1	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.05853987151003438	[507]	[835,613,432,381]	-1	hSpCas9	negative selection	7448143
73170854	73170877	14	-	27260156	MEWO	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.3376583150245358	[101]	[121,124,114]	7	hSpCas9	negative selection	7505133
73217222	73217245	14	-	27260156	MEWO	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.3208025288030209	[745]	[830,548,348]	-6	hSpCas9	negative selection	7505134
73170871	73170894	14	+	27260156	MEWO	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.34269779262575667	[503]	[605,654,533]	7	hSpCas9	negative selection	7505135
73173656	73173679	14	+	27260156	MEWO	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.16750821406279343	[533]	[580,394,384]	-4	hSpCas9	negative selection	7569392
73173576	73173599	14	-	27260156	MEWO	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.18608290651139428	[520]	[653,501,526]	4	hSpCas9	negative selection	7569393
73217195	73217218	14	-	27260156	MEWO	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.050386173748261195	[507]	[534,422,526]	1	hSpCas9	negative selection	7569394
73170854	73170877	14	-	27260156	LNCAPCLONEFGC	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.21688704332830078	[101]	[87,97,68,59]	-3	hSpCas9	negative selection	7626384
73217222	73217245	14	-	27260156	LNCAPCLONEFGC	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.01818712190656746	[745]	[677,546,764,700]	0	hSpCas9	negative selection	7626385
73170871	73170894	14	+	27260156	LNCAPCLONEFGC	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.2558697787870981	[503]	[508,594,513,554]	4	hSpCas9	negative selection	7626386
73173656	73173679	14	+	27260156	LNCAPCLONEFGC	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.17198959948358145	[533]	[391,442,388,486]	-3	hSpCas9	negative selection	7690643
73173576	73173599	14	-	27260156	LNCAPCLONEFGC	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.16970320953549148	[520]	[594,522,487,509]	2	hSpCas9	negative selection	7690644
73217195	73217218	14	-	27260156	LNCAPCLONEFGC	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.07834655423853859	[507]	[375,362,596,436]	-1	hSpCas9	negative selection	7690645
73170854	73170877	14	-	27260156	PANC0327	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.21478713309260766	[101]	[119,70,24,209]	3	hSpCas9	negative selection	7747635
73217222	73217245	14	-	27260156	PANC0327	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.25996117722705236	[745]	[690,442,550,553]	-4	hSpCas9	negative selection	7747636
73170871	73170894	14	+	27260156	PANC0327	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	-0.1596682212615639	[503]	[406,271,346,593]	-2	hSpCas9	negative selection	7747637
73173656	73173679	14	+	27260156	PANC0327	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.024410254396662473	[533]	[550,452,398,470]	0	hSpCas9	negative selection	7811894
73173576	73173599	14	-	27260156	PANC0327	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.5741381172508496	[520]	[730,598,727,712]	8	hSpCas9	negative selection	7811895
73217195	73217218	14	-	27260156	PANC0327	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.5598348288794158	[507]	[309,226,353,343]	-7	hSpCas9	negative selection	7811896
73170854	73170877	14	-	27260156	NCIH2009	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.4561962823359704	[101]	[120,149,42]	-5	hSpCas9	negative selection	7868886
73217222	73217245	14	-	27260156	NCIH2009	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.14805229237131667	[745]	[759,916,1107]	-2	hSpCas9	negative selection	7868887
73170871	73170894	14	+	27260156	NCIH2009	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.7113536205574019	[503]	[1446,934,1136]	8	hSpCas9	negative selection	7868888
73173656	73173679	14	+	27260156	NCIH2009	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.012240650769456962	[533]	[981,516,770]	0	hSpCas9	negative selection	7933145
73173576	73173599	14	-	27260156	NCIH2009	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.3916372082953795	[520]	[1063,996,822]	5	hSpCas9	negative selection	7933146
73217195	73217218	14	-	27260156	NCIH2009	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.020622001740169954	[507]	[957,584,607]	0	hSpCas9	negative selection	7933147
73170854	73170877	14	-	27260156	NCIH1373	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.3225025121983611	[101]	[220,95,20,11]	-3	hSpCas9	negative selection	7990137
73217222	73217245	14	-	27260156	NCIH1373	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	0.04932546422881601	[745]	[594,481,615,479]	0	hSpCas9	negative selection	7990138
73170871	73170894	14	+	27260156	NCIH1373	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.7248201200101082	[503]	[1209,853,654,282]	7	hSpCas9	negative selection	7990139
73173656	73173679	14	+	27260156	NCIH1373	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.7253602128064618	[533]	[471,323,443,56]	-6	hSpCas9	negative selection	8054396
73173576	73173599	14	-	27260156	NCIH1373	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.6631978815678523	[520]	[1062,952,725,256]	6	hSpCas9	negative selection	8054397
73217195	73217218	14	-	27260156	NCIH1373	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.6287628084954738	[507]	[495,230,240,144]	-6	hSpCas9	negative selection	8054398
73170854	73170877	14	-	27260156	PATU8902	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.8181106279941464	[101]	[349,407,193,35]	8	hSpCas9	negative selection	8111388
73217222	73217245	14	-	27260156	PATU8902	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	0.3919494947339093	[745]	[1296,1843,764,1738]	4	hSpCas9	negative selection	8111389
73170871	73170894	14	+	27260156	PATU8902	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.4944390424134292	[503]	[1157,1238,681,940]	5	hSpCas9	negative selection	8111390
73173656	73173679	14	+	27260156	PATU8902	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.19150637467187628	[533]	[235,1076,352,1067]	-2	hSpCas9	negative selection	8175647
73173576	73173599	14	-	27260156	PATU8902	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.49433661530568085	[520]	[1226,526,893,1520]	5	hSpCas9	negative selection	8175648
73217195	73217218	14	-	27260156	PATU8902	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.15853445526653565	[507]	[527,536,569,950]	-2	hSpCas9	negative selection	8175649
73170854	73170877	14	-	27260156	PANC1	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.03747596066333214	[101]	[87,140,49,73]	0	hSpCas9	negative selection	8232639
73217222	73217245	14	-	27260156	PANC1	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.06750824558956048	[745]	[565,704,761,450]	-1	hSpCas9	negative selection	8232640
73170871	73170894	14	+	27260156	PANC1	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.17279313009479264	[503]	[515,787,326,388]	2	hSpCas9	negative selection	8232641
73173656	73173679	14	+	27260156	PANC1	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.0575344846429558	[533]	[407,317,452,535]	-1	hSpCas9	negative selection	8296898
73173576	73173599	14	-	27260156	PANC1	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.2692777768424982	[520]	[494,820,518,395]	4	hSpCas9	negative selection	8296899
73217195	73217218	14	-	27260156	PANC1	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.5581048014276863	[507]	[324,384,242,251]	-7	hSpCas9	negative selection	8296900
73170854	73170877	14	-	27260156	PANC0813	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-1.244034858302972	[101]	[50,41,52,55]	-9	hSpCas9	negative selection	8353890
73217222	73217245	14	-	27260156	PANC0813	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.4520269297435718	[745]	[697,807,463,597]	-6	hSpCas9	negative selection	8353891
73170871	73170894	14	+	27260156	PANC0813	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.15563059515244176	[503]	[807,683,606,556]	2	hSpCas9	negative selection	8353892
73173656	73173679	14	+	27260156	PANC0813	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.5836906280448558	[533]	[479,482,390,329]	-7	hSpCas9	negative selection	8418149
73173576	73173599	14	-	27260156	PANC0813	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.2795783482632913	[520]	[674,514,938,830]	4	hSpCas9	negative selection	8418150
73217195	73217218	14	-	27260156	PANC0813	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.18792584596744993	[507]	[491,423,476,688]	-3	hSpCas9	negative selection	8418151
73170854	73170877	14	-	27260156	RDES	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-1.1651799115792896	[101]	[37,76,60,28]	-9	hSpCas9	negative selection	8475141
73217222	73217245	14	-	27260156	RDES	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.27657524930684874	[745]	[655,682,638,866]	-5	hSpCas9	negative selection	8475142
73170871	73170894	14	+	27260156	RDES	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.34009835863855176	[503]	[707,693,684,847]	5	hSpCas9	negative selection	8475143
73173656	73173679	14	+	27260156	RDES	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.09670316542580365	[533]	[533,644,446,661]	-2	hSpCas9	negative selection	8539400
73173576	73173599	14	-	27260156	RDES	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.46685490291452136	[520]	[564,891,919,990]	7	hSpCas9	negative selection	8539401
73217195	73217218	14	-	27260156	RDES	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.08416424866064766	[507]	[534,545,654,771]	1	hSpCas9	negative selection	8539402
73170854	73170877	14	-	27260156	PC3	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.26324237545907936	[101]	[69,80,77,103]	-5	hSpCas9	negative selection	8596392
73217222	73217245	14	-	27260156	PC3	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.26838496727664535	[745]	[405,544,1184,587]	-6	hSpCas9	negative selection	8596393
73170871	73170894	14	+	27260156	PC3	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.05799391480627074	[503]	[300,514,603,763]	1	hSpCas9	negative selection	8596394
73173656	73173679	14	+	27260156	PC3	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.6304205425441561	[533]	[146,240,753,467]	-8	hSpCas9	negative selection	8660651
73173576	73173599	14	-	27260156	PC3	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.1278252980425247	[520]	[277,536,1403,456]	3	hSpCas9	negative selection	8660652
73217195	73217218	14	-	27260156	PC3	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.26108818066157036	[507]	[234,546,743,321]	-5	hSpCas9	negative selection	8660653
73170854	73170877	14	-	27260156	PATU8988T	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.4569230382179925	[101]	[19,182,133,214]	7	hSpCas9	negative selection	8717643
73217222	73217245	14	-	27260156	PATU8988T	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.11879134719229933	[745]	[685,509,714,734]	-2	hSpCas9	negative selection	8717644
73170871	73170894	14	+	27260156	PATU8988T	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.13964692340518553	[503]	[766,494,323,560]	2	hSpCas9	negative selection	8717645
73173656	73173679	14	+	27260156	PATU8988T	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.10308610999194799	[533]	[520,522,398,483]	-2	hSpCas9	negative selection	8781902
73173576	73173599	14	-	27260156	PATU8988T	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.459942911174021	[520]	[822,626,647,663]	7	hSpCas9	negative selection	8781903
73217195	73217218	14	-	27260156	PATU8988T	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.25865194131263936	[507]	[627,625,459,644]	4	hSpCas9	negative selection	8781904
73170854	73170877	14	-	27260156	T47D	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.20289619626267763	[101]	[131,133,126,154]	4	hSpCas9	negative selection	8838894
73217222	73217245	14	-	27260156	T47D	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.12573370463145406	[745]	[806,659,905,823]	-3	hSpCas9	negative selection	8838895
73170871	73170894	14	+	27260156	T47D	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.16651068609466974	[503]	[781,567,686,604]	3	hSpCas9	negative selection	8838896
73173656	73173679	14	+	27260156	T47D	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.2013287107594539	[533]	[492,551,563,553]	-4	hSpCas9	negative selection	8903153
73173576	73173599	14	-	27260156	T47D	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.1421767722845149	[520]	[713,636,665,664]	3	hSpCas9	negative selection	8903154
73217195	73217218	14	-	27260156	T47D	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.14482206560368138	[507]	[520,486,561,575]	-3	hSpCas9	negative selection	8903155
73170854	73170877	14	-	27260156	SU8686	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.5655225992231925	[101]	[63,68,73,65]	-7	hSpCas9	negative selection	8960145
73217222	73217245	14	-	27260156	SU8686	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.38466730777622626	[745]	[448,568,590,685]	-6	hSpCas9	negative selection	8960146
73170871	73170894	14	+	27260156	SU8686	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.03731896895129368	[503]	[550,394,450,687]	0	hSpCas9	negative selection	8960147
73173656	73173679	14	+	27260156	SU8686	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.40630739736964605	[533]	[354,425,428,384]	-6	hSpCas9	negative selection	9024404
73173576	73173599	14	-	27260156	SU8686	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.1266767798867228	[520]	[463,454,724,651]	2	hSpCas9	negative selection	9024405
73217195	73217218	14	-	27260156	SU8686	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.09734553758638165	[507]	[539,419,487,422]	-2	hSpCas9	negative selection	9024406
73170854	73170877	14	-	27260156	SKES1	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.015418990853340198	[101]	[54,117,122,100]	0	hSpCas9	negative selection	9081396
73217222	73217245	14	-	27260156	SKES1	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.15163817406434588	[745]	[816,658,627,596]	-3	hSpCas9	negative selection	9081397
73170871	73170894	14	+	27260156	SKES1	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.18661922346262094	[503]	[673,669,509,467]	4	hSpCas9	negative selection	9081398
73173656	73173679	14	+	27260156	SKES1	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.0874560796046819	[533]	[532,465,372,615]	-2	hSpCas9	negative selection	9145655
73173576	73173599	14	-	27260156	SKES1	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.09373467439265004	[520]	[646,673,509,424]	2	hSpCas9	negative selection	9145656
73217195	73217218	14	-	27260156	SKES1	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.025093985204946198	[507]	[516,648,445,467]	0	hSpCas9	negative selection	9145657
73170854	73170877	14	-	27260156	TOV112D	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.03851502948181951	[101]	[135,33,90,122]	0	hSpCas9	negative selection	9202647
73217222	73217245	14	-	27260156	TOV112D	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.2625761651872332	[745]	[881,695,578,379]	-5	hSpCas9	negative selection	9202648
73170871	73170894	14	+	27260156	TOV112D	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.5064895722020449	[503]	[682,942,870,430]	8	hSpCas9	negative selection	9202649
73173656	73173679	14	+	27260156	TOV112D	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.3215134761298972	[533]	[579,380,378,373]	-6	hSpCas9	negative selection	9266906
73173576	73173599	14	-	27260156	TOV112D	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.14984012823701262	[520]	[558,665,549,559]	3	hSpCas9	negative selection	9266907
73217195	73217218	14	-	27260156	TOV112D	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.281995055004651	[507]	[689,912,586,368]	5	hSpCas9	negative selection	9266908
73170854	73170877	14	-	27260156	TC71	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	0.19537429522691951	[101]	[125,143,89,142]	5	hSpCas9	negative selection	9323898
73217222	73217245	14	-	27260156	TC71	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	-0.15039662829743838	[745]	[669,797,594,830]	-4	hSpCas9	negative selection	9323899
73170871	73170894	14	+	27260156	TC71	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.1078790794152006	[503]	[518,656,467,696]	2	hSpCas9	negative selection	9323900
73173656	73173679	14	+	27260156	TC71	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.2321586942624238	[533]	[388,493,602,459]	-6	hSpCas9	negative selection	9388157
73173576	73173599	14	-	27260156	TC71	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	0.1244435355377124	[520]	[552,570,544,779]	3	hSpCas9	negative selection	9388158
73217195	73217218	14	-	27260156	TC71	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	0.07531034642192942	[507]	[672,583,526,505]	2	hSpCas9	negative selection	9388159
73170854	73170877	14	-	27260156	TC32	viability	TGGGGTCGTCCATTAGATAATGG	PSEN1	ENSG00000080815	-0.8399672806429561	[101]	[34,3,153,57]	-9	hSpCas9	negative selection	9445149
73217222	73217245	14	-	27260156	TC32	viability	AATTAATATGGCTACGAAACAGG	PSEN1	ENSG00000080815	0.13792077754096144	[745]	[677,617,971,881]	2	hSpCas9	negative selection	9445150
73170871	73170894	14	+	27260156	TC32	viability	ACCCCAGGGTAACTCCCGGCAGG	PSEN1	ENSG00000080815	0.08252572693422101	[503]	[403,362,826,504]	1	hSpCas9	negative selection	9445151
73173656	73173679	14	+	27260156	TC32	viability	TGTTGTCATGACTATCCTCCTGG	PSEN1	ENSG00000080815	-0.24639025688796978	[533]	[357,307,488,584]	-4	hSpCas9	negative selection	9509408
73173576	73173599	14	-	27260156	TC32	viability	GTCTCGGTATCTTCTGTGAATGG	PSEN1	ENSG00000080815	-0.01995913064982044	[520]	[301,427,596,648]	0	hSpCas9	negative selection	9509409
73217195	73217218	14	-	27260156	TC32	viability	GGTTGTGTTCCAGTCTCCACTGG	PSEN1	ENSG00000080815	-0.2277643992630366	[507]	[368,263,664,413]	-4	hSpCas9	negative selection	9509410
73148079	73148102	14	-	27869803	HPAFII	viability after 27 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.9979866528230752	[181]	[12,76,NaN]	-6	hSpCas9	negative selection	9552269
73170796	73170819	14	+	27869803	HPAFII	viability after 27 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-1.1134468138843514	[106]	[55,0,NaN]	-6	hSpCas9	negative selection	9552270
73173736	73173759	14	-	27869803	HPAFII	viability after 27 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	1.018538187912136	[182]	[255,143,NaN]	8	hSpCas9	negative selection	9552271
73192779	73192802	14	+	27869803	HPAFII	viability after 27 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.049030159647745375	[58]	[30,32,NaN]	0	hSpCas9	negative selection	9552272
73206397	73206420	14	+	27869803	HPAFII	viability after 27 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	0.33935578145424977	[160]	[111,102,NaN]	2	hSpCas9	negative selection	9552273
73211811	73211834	14	+	27869803	HPAFII	viability after 27 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.30654374318205696	[334]	[207,225,NaN]	2	hSpCas9	negative selection	9552274
73148079	73148102	14	-	27869803	HPAFII	viability after 15 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.8779451197788328	[181]	[119,97,NaN]	-7	hSpCas9	negative selection	9634718
73170796	73170819	14	+	27869803	HPAFII	viability after 15 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-1.2795082944804415	[106]	[92,18,NaN]	-8	hSpCas9	negative selection	9634719
73173736	73173759	14	-	27869803	HPAFII	viability after 15 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	0.5282319257414267	[182]	[504,145,NaN]	6	hSpCas9	negative selection	9634720
73192779	73192802	14	+	27869803	HPAFII	viability after 15 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	1.0175584579622583	[58]	[173,99,NaN]	9	hSpCas9	negative selection	9634721
73206397	73206420	14	+	27869803	HPAFII	viability after 15 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-0.4159193819224669	[160]	[244,57,NaN]	-4	hSpCas9	negative selection	9634722
73211811	73211834	14	+	27869803	HPAFII	viability after 15 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.09326296709205467	[334]	[499,311,NaN]	1	hSpCas9	negative selection	9634723
73148079	73148102	14	-	27869803	ASPC1	viability after 36 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	1.0158696862554013	[351]	[170,317,244]	8	hSpCas9	negative selection	9717167
73170796	73170819	14	+	27869803	ASPC1	viability after 36 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-1.2019647140710554	[214]	[0,70,23]	-8	hSpCas9	negative selection	9717168
73173736	73173759	14	-	27869803	ASPC1	viability after 36 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	0.08676489673455567	[419]	[232,26,201]	0	hSpCas9	negative selection	9717169
73192779	73192802	14	+	27869803	ASPC1	viability after 36 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.46155374495606694	[278]	[296,82,58]	4	hSpCas9	negative selection	9717170
73206397	73206420	14	+	27869803	ASPC1	viability after 36 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-0.049912021249989946	[460]	[350,91,66]	0	hSpCas9	negative selection	9717171
73211811	73211834	14	+	27869803	ASPC1	viability after 36 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.48549091232913777	[928]	[600,394,392]	5	hSpCas9	negative selection	9717172
73148079	73148102	14	-	27869803	PATU8988S	viability after 35 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.5219429207110649	[393]	[115,104,NaN]	-5	hSpCas9	negative selection	9799616
73170796	73170819	14	+	27869803	PATU8988S	viability after 35 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-0.23505107885234056	[110]	[30,44,NaN]	-2	hSpCas9	negative selection	9799617
73173736	73173759	14	-	27869803	PATU8988S	viability after 35 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	0.23097662678822423	[479]	[176,276,NaN]	2	hSpCas9	negative selection	9799618
73192779	73192802	14	+	27869803	PATU8988S	viability after 35 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	1.1676810588785012	[226]	[154,255,NaN]	9	hSpCas9	negative selection	9799619
73206397	73206420	14	+	27869803	PATU8988S	viability after 35 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-1.2095039818436975	[395]	[53,83,NaN]	-8	hSpCas9	negative selection	9799620
73211811	73211834	14	+	27869803	PATU8988S	viability after 35 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	-0.09775083451962918	[841]	[272,360,NaN]	-1	hSpCas9	negative selection	9799621
73148079	73148102	14	-	27869803	PATU8988S	viability after 31 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.7250748845289248	[393]	[109,75,NaN]	-6	hSpCas9	negative selection	9882065
73170796	73170819	14	+	27869803	PATU8988S	viability after 31 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-0.749751716390878	[110]	[35,13,NaN]	-7	hSpCas9	negative selection	9882066
73173736	73173759	14	-	27869803	PATU8988S	viability after 31 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	-0.37881621239835156	[479]	[133,163,NaN]	-4	hSpCas9	negative selection	9882067
73192779	73192802	14	+	27869803	PATU8988S	viability after 31 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	1.0922570841058137	[226]	[115,290,NaN]	9	hSpCas9	negative selection	9882068
73206397	73206420	14	+	27869803	PATU8988S	viability after 31 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-1.2230962816720066	[395]	[64,70,NaN]	-8	hSpCas9	negative selection	9882069
73211811	73211834	14	+	27869803	PATU8988S	viability after 31 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.19172424575520686	[841]	[287,504,NaN]	2	hSpCas9	negative selection	9882070
73148079	73148102	14	-	27869803	HPAFII	viability after 35 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-1.703963610282301	[181]	[0,58,NaN]	-7	hSpCas9	negative selection	9964514
73170796	73170819	14	+	27869803	HPAFII	viability after 35 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-2.8805096680396307	[106]	[12,0,NaN]	-8	hSpCas9	negative selection	9964515
73173736	73173759	14	-	27869803	HPAFII	viability after 35 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	1.5855964195411856	[182]	[381,160,NaN]	9	hSpCas9	negative selection	9964516
73192779	73192802	14	+	27869803	HPAFII	viability after 35 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	1.2904413031070578	[58]	[73,71,NaN]	8	hSpCas9	negative selection	9964517
73206397	73206420	14	+	27869803	HPAFII	viability after 35 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	-0.11978155857370221	[160]	[98,47,NaN]	0	hSpCas9	negative selection	9964518
73211811	73211834	14	+	27869803	HPAFII	viability after 35 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.969024817648044	[334]	[172,510,NaN]	6	hSpCas9	negative selection	9964519
73148079	73148102	14	-	27869803	HPAFII	viability after 31 days	TACGTACAGTATTGCTCAGGTGG	PSEN1	ENSG00000080815	-0.7815120557077699	[181]	[12,109,NaN]	-5	hSpCas9	negative selection	10046963
73170796	73170819	14	+	27869803	HPAFII	viability after 31 days	GAATGACAATAGAGAACGGCAGG	PSEN1	ENSG00000080815	-1.8512645641292134	[106]	[30,0,NaN]	-8	hSpCas9	negative selection	10046964
73173736	73173759	14	-	27869803	HPAFII	viability after 31 days	CAACCATAAGAAGAACAGGGTGG	PSEN1	ENSG00000080815	1.4447813393526294	[182]	[392,155,NaN]	9	hSpCas9	negative selection	10046965
73192779	73192802	14	+	27869803	HPAFII	viability after 31 days	GATTAGTGCCCTCATGGCCCTGG	PSEN1	ENSG00000080815	0.24272103865900507	[58]	[31,46,NaN]	1	hSpCas9	negative selection	10046966
73206397	73206420	14	+	27869803	HPAFII	viability after 31 days	TGGTTGGTGAATATGGCAGAAGG	PSEN1	ENSG00000080815	0.23076359031320004	[160]	[128,80,NaN]	1	hSpCas9	negative selection	10046967
73211811	73211834	14	+	27869803	HPAFII	viability after 31 days	ATGGCGGGTTCAGTGAGGAATGG	PSEN1	ENSG00000080815	0.7427287748584472	[334]	[193,445,NaN]	5	hSpCas9	negative selection	10046968
73170889	73170912	14	+	28162770	P31FUJ	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.5668708621739529	[357]	[141]	-7	hSpCas9	negative selection	10218541
73211933	73211956	14	-	28162770	P31FUJ	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	0.42443619728109333	[278]	[439]	5	hSpCas9	negative selection	10218542
73170973	73170996	14	+	28162770	P31FUJ	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	0.13520176102095766	[264]	[341]	1	hSpCas9	negative selection	10218543
73192815	73192838	14	-	28162770	P31FUJ	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	-0.042699321034435994	[212]	[242]	0	hSpCas9	negative selection	10218544
73211823	73211846	14	+	28162770	P31FUJ	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	0.173823055048265	[128]	[170]	1	hSpCas9	negative selection	10218545
73217179	73217202	14	+	28162770	P31FUJ	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.19237985227000842	[247]	[332]	2	hSpCas9	negative selection	10218546
73148038	73148061	14	-	28162770	P31FUJ	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	0.08790791231631212	[236]	[295]	0	hSpCas9	negative selection	10218547
73170813	73170836	14	+	28162770	P31FUJ	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	0.6204624215151988	[242]	[438]	7	hSpCas9	negative selection	10218548
73173671	73173694	14	-	28162770	P31FUJ	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.32326415067232195	[352]	[518]	3	hSpCas9	negative selection	10218549
73192796	73192819	14	-	28162770	P31FUJ	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	-0.2926736603917772	[122]	[117]	-3	hSpCas9	negative selection	10218550
73170889	73170912	14	+	28162770	TF1	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	NaN	[NaN]	[74]	1	hSpCas9	negative selection	10387907
73211933	73211956	14	-	28162770	TF1	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	NaN	[NaN]	[101]	1	hSpCas9	negative selection	10387908
73170973	73170996	14	+	28162770	TF1	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	NaN	[NaN]	[289]	1	hSpCas9	negative selection	10387909
73192815	73192838	14	-	28162770	TF1	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	NaN	[NaN]	[186]	1	hSpCas9	negative selection	10387910
73211823	73211846	14	+	28162770	TF1	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	NaN	[NaN]	[29]	1	hSpCas9	negative selection	10387911
73217179	73217202	14	+	28162770	TF1	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	NaN	[NaN]	[294]	1	hSpCas9	negative selection	10387912
73148038	73148061	14	-	28162770	TF1	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	NaN	[NaN]	[171]	1	hSpCas9	negative selection	10387913
73170813	73170836	14	+	28162770	TF1	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	NaN	[NaN]	[176]	1	hSpCas9	negative selection	10387914
73173671	73173694	14	-	28162770	TF1	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	NaN	[NaN]	[436]	1	hSpCas9	negative selection	10387915
73192796	73192819	14	-	28162770	TF1	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	NaN	[NaN]	[101]	1	hSpCas9	negative selection	10387916
73170889	73170912	14	+	28162770	SKM1	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.3859025832153318	[101]	[68]	-7	hSpCas9	negative selection	10557273
73211933	73211956	14	-	28162770	SKM1	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	0.9556058806415466	[48]	[167]	8	hSpCas9	negative selection	10557274
73170973	73170996	14	+	28162770	SKM1	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	1.352496033210131	[69]	[315]	9	hSpCas9	negative selection	10557275
73192815	73192838	14	-	28162770	SKM1	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	0.703089346721752	[40]	[117]	6	hSpCas9	negative selection	10557276
73211823	73211846	14	+	28162770	SKM1	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	-1.4624593113348652	[52]	[33]	-7	hSpCas9	negative selection	10557277
73217179	73217202	14	+	28162770	SKM1	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.6393294535307732	[68]	[189]	6	hSpCas9	negative selection	10557278
73148038	73148061	14	-	28162770	SKM1	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	-0.1260078849121055	[49]	[80]	-1	hSpCas9	negative selection	10557279
73170813	73170836	14	+	28162770	SKM1	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	1.5150332892555651	[37]	[191]	9	hSpCas9	negative selection	10557280
73173671	73173694	14	-	28162770	SKM1	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.7273368929684295	[81]	[239]	7	hSpCas9	negative selection	10557281
73192796	73192819	14	-	28162770	SKM1	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	0.8409633147004237	[29]	[94]	7	hSpCas9	negative selection	10557282
73170889	73170912	14	+	28162770	SKM1	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.3859025832153318	[101]	[68]	-7	hSpCas9	negative selection	10726639
73211933	73211956	14	-	28162770	SKM1	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	0.9556058806415466	[48]	[167]	8	hSpCas9	negative selection	10726640
73170973	73170996	14	+	28162770	SKM1	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	1.352496033210131	[69]	[315]	9	hSpCas9	negative selection	10726641
73192815	73192838	14	-	28162770	SKM1	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	0.703089346721752	[40]	[117]	6	hSpCas9	negative selection	10726642
73211823	73211846	14	+	28162770	SKM1	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	-1.4624593113348652	[52]	[33]	-7	hSpCas9	negative selection	10726643
73217179	73217202	14	+	28162770	SKM1	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.6393294535307732	[68]	[189]	6	hSpCas9	negative selection	10726644
73148038	73148061	14	-	28162770	SKM1	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	-0.1260078849121055	[49]	[80]	-1	hSpCas9	negative selection	10726645
73170813	73170836	14	+	28162770	SKM1	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	1.5150332892555651	[37]	[191]	9	hSpCas9	negative selection	10726646
73173671	73173694	14	-	28162770	SKM1	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.7273368929684295	[81]	[239]	7	hSpCas9	negative selection	10726647
73192796	73192819	14	-	28162770	SKM1	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	0.8409633147004237	[29]	[94]	7	hSpCas9	negative selection	10726648
73170889	73170912	14	+	28162770	PL21	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.4289699899162183	[364]	[58]	-7	hSpCas9	negative selection	10896005
73211933	73211956	14	-	28162770	PL21	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	0.48497839064146225	[196]	[119]	4	hSpCas9	negative selection	10896006
73170973	73170996	14	+	28162770	PL21	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	-0.2716839108811009	[379]	[136]	-2	hSpCas9	negative selection	10896007
73192815	73192838	14	-	28162770	PL21	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	0.08466239706938412	[181]	[83]	0	hSpCas9	negative selection	10896008
73211823	73211846	14	+	28162770	PL21	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	-1.7738651769777354	[164]	[20]	-8	hSpCas9	negative selection	10896009
73217179	73217202	14	+	28162770	PL21	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.1822177064920577	[323]	[159]	1	hSpCas9	negative selection	10896010
73148038	73148061	14	-	28162770	PL21	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	1.1638434852663302	[160]	[156]	8	hSpCas9	negative selection	10896011
73170813	73170836	14	+	28162770	PL21	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	-0.44494387866940693	[146]	[46]	-3	hSpCas9	negative selection	10896012
73173671	73173694	14	-	28162770	PL21	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	1.5575663905980688	[280]	[359]	9	hSpCas9	negative selection	10896013
73192796	73192819	14	-	28162770	PL21	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	0.8509900508669336	[106]	[83]	7	hSpCas9	negative selection	10896014
73170889	73170912	14	+	28162770	P31FUJ	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.5668708621739529	[357]	[141]	-7	hSpCas9	negative selection	11065371
73211933	73211956	14	-	28162770	P31FUJ	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	0.42443619728109333	[278]	[439]	5	hSpCas9	negative selection	11065372
73170973	73170996	14	+	28162770	P31FUJ	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	0.13520176102095766	[264]	[341]	1	hSpCas9	negative selection	11065373
73192815	73192838	14	-	28162770	P31FUJ	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	-0.042699321034435994	[212]	[242]	0	hSpCas9	negative selection	11065374
73211823	73211846	14	+	28162770	P31FUJ	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	0.173823055048265	[128]	[170]	1	hSpCas9	negative selection	11065375
73217179	73217202	14	+	28162770	P31FUJ	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.19237985227000842	[247]	[332]	2	hSpCas9	negative selection	11065376
73148038	73148061	14	-	28162770	P31FUJ	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	0.08790791231631212	[236]	[295]	0	hSpCas9	negative selection	11065377
73170813	73170836	14	+	28162770	P31FUJ	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	0.6204624215151988	[242]	[438]	7	hSpCas9	negative selection	11065378
73173671	73173694	14	-	28162770	P31FUJ	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.32326415067232195	[352]	[518]	3	hSpCas9	negative selection	11065379
73192796	73192819	14	-	28162770	P31FUJ	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	-0.2926736603917772	[122]	[117]	-3	hSpCas9	negative selection	11065380
73170889	73170912	14	+	28162770	OCIAML5	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.9443250787159856	[225]	[105]	-8	hSpCas9	negative selection	11234737
73211933	73211956	14	-	28162770	OCIAML5	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	0.342482217547138	[141]	[324]	3	hSpCas9	negative selection	11234738
73170973	73170996	14	+	28162770	OCIAML5	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	0.9880620923576134	[142]	[511]	8	hSpCas9	negative selection	11234739
73192815	73192838	14	-	28162770	OCIAML5	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	-1.5682736048634058	[68]	[41]	-7	hSpCas9	negative selection	11234740
73211823	73211846	14	+	28162770	OCIAML5	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	-2.0626335568036547	[80]	[34]	-8	hSpCas9	negative selection	11234741
73217179	73217202	14	+	28162770	OCIAML5	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.8858294941767	[154]	[516]	7	hSpCas9	negative selection	11234742
73148038	73148061	14	-	28162770	OCIAML5	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	0.06547126894402996	[107]	[203]	0	hSpCas9	negative selection	11234743
73170813	73170836	14	+	28162770	OCIAML5	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	0.1989574321604698	[124]	[258]	1	hSpCas9	negative selection	11234744
73173671	73173694	14	-	28162770	OCIAML5	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.38091060111361674	[193]	[455]	3	hSpCas9	negative selection	11234745
73192796	73192819	14	-	28162770	OCIAML5	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	-0.2586918303266408	[56]	[85]	-2	hSpCas9	negative selection	11234746
73170889	73170912	14	+	28162770	EOL1	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.3924395820465576	[582]	[116]	-7	hSpCas9	negative selection	11404103
73211933	73211956	14	-	28162770	EOL1	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	-1.1772057272301986	[278]	[64]	-7	hSpCas9	negative selection	11404104
73170973	73170996	14	+	28162770	EOL1	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	1.0728580502770524	[664]	[736]	8	hSpCas9	negative selection	11404105
73192815	73192838	14	-	28162770	EOL1	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	0.28231046549762917	[333]	[213]	2	hSpCas9	negative selection	11404106
73211823	73211846	14	+	28162770	EOL1	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	-0.5567511699770304	[348]	[124]	-4	hSpCas9	negative selection	11404107
73217179	73217202	14	+	28162770	EOL1	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.4661601971526451	[517]	[376]	4	hSpCas9	negative selection	11404108
73148038	73148061	14	-	28162770	EOL1	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	1.024083445121449	[167]	[179]	8	hSpCas9	negative selection	11404109
73170813	73170836	14	+	28162770	EOL1	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	-0.7218152738147647	[215]	[68]	-5	hSpCas9	negative selection	11404110
73173671	73173694	14	-	28162770	EOL1	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.76072296966464	[353]	[315]	6	hSpCas9	negative selection	11404111
73192796	73192819	14	-	28162770	EOL1	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	-0.15637222381303284	[164]	[77]	-1	hSpCas9	negative selection	11404112
73170889	73170912	14	+	28162770	MOLM13	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.8925919541121767	[492]	[95]	-7	hSpCas9	negative selection	11573469
73211933	73211956	14	-	28162770	MOLM13	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	-0.17089581868272408	[354]	[227]	-1	hSpCas9	negative selection	11573470
73170973	73170996	14	+	28162770	MOLM13	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	1.2503659997298664	[492]	[847]	8	hSpCas9	negative selection	11573471
73192815	73192838	14	-	28162770	MOLM13	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	0.9533162087148207	[254]	[356]	7	hSpCas9	negative selection	11573472
73211823	73211846	14	+	28162770	MOLM13	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	-1.2501346489681673	[226]	[68]	-6	hSpCas9	negative selection	11573473
73217179	73217202	14	+	28162770	MOLM13	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	1.5616427025014872	[349]	[746]	9	hSpCas9	negative selection	11573474
73148038	73148061	14	-	28162770	MOLM13	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	-1.6475878358753573	[233]	[53]	-7	hSpCas9	negative selection	11573475
73170813	73170836	14	+	28162770	MOLM13	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	0.5929665145946962	[264]	[288]	4	hSpCas9	negative selection	11573476
73173671	73173694	14	-	28162770	MOLM13	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.3398095676300249	[411]	[376]	2	hSpCas9	negative selection	11573477
73192796	73192819	14	-	28162770	MOLM13	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	-0.7987116393094071	[242]	[100]	-4	hSpCas9	negative selection	11573478
73170889	73170912	14	+	28162770	HEL	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.2180253706284712	[453]	[124]	-6	hSpCas9	negative selection	11742835
73211933	73211956	14	-	28162770	HEL	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	0.642738832000357	[277]	[277]	5	hSpCas9	negative selection	11742836
73170973	73170996	14	+	28162770	HEL	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	0.9285566334784385	[355]	[433]	7	hSpCas9	negative selection	11742837
73192815	73192838	14	-	28162770	HEL	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	0.7443369720081637	[232]	[249]	6	hSpCas9	negative selection	11742838
73211823	73211846	14	+	28162770	HEL	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	-0.6561056497739642	[154]	[62]	-4	hSpCas9	negative selection	11742839
73217179	73217202	14	+	28162770	HEL	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.7916772508125755	[376]	[417]	7	hSpCas9	negative selection	11742840
73148038	73148061	14	-	28162770	HEL	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	1.557968728521605	[183]	[346]	9	hSpCas9	negative selection	11742841
73170813	73170836	14	+	28162770	HEL	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	0.8792754356570746	[173]	[204]	7	hSpCas9	negative selection	11742842
73173671	73173694	14	-	28162770	HEL	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.4583142608629295	[349]	[307]	4	hSpCas9	negative selection	11742843
73192796	73192819	14	-	28162770	HEL	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	-0.39813344941517115	[178]	[86]	-3	hSpCas9	negative selection	11742844
73170889	73170912	14	+	28162770	MV411	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.3904364809768235	[360]	[115]	-7	hSpCas9	negative selection	11912201
73211933	73211956	14	-	28162770	MV411	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	-0.03635541521781574	[167]	[137]	0	hSpCas9	negative selection	11912202
73170973	73170996	14	+	28162770	MV411	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	1.3747418750578535	[270]	[591]	9	hSpCas9	negative selection	11912203
73192815	73192838	14	-	28162770	MV411	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	1.3660820472813944	[174]	[379]	9	hSpCas9	negative selection	11912204
73211823	73211846	14	+	28162770	MV411	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	-1.939263163410364	[172]	[37]	-8	hSpCas9	negative selection	11912205
73217179	73217202	14	+	28162770	MV411	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.8925210439415023	[281]	[440]	7	hSpCas9	negative selection	11912206
73148038	73148061	14	-	28162770	MV411	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	0.5693656456701377	[143]	[179]	5	hSpCas9	negative selection	11912207
73170813	73170836	14	+	28162770	MV411	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	0.9858973916293118	[192]	[321]	8	hSpCas9	negative selection	11912208
73173671	73173694	14	-	28162770	MV411	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	1.0872803255892838	[275]	[493]	8	hSpCas9	negative selection	11912209
73192796	73192819	14	-	28162770	MV411	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	0.5421808163439074	[74]	[91]	5	hSpCas9	negative selection	11912210
73170889	73170912	14	+	28162770	MONOMAC1	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.1404533186931864	[249]	[129]	-7	hSpCas9	negative selection	12081567
73211933	73211956	14	-	28162770	MONOMAC1	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	0.16553323232515452	[111]	[143]	1	hSpCas9	negative selection	12081568
73170973	73170996	14	+	28162770	MONOMAC1	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	0.8778171476246597	[168]	[355]	7	hSpCas9	negative selection	12081569
73192815	73192838	14	-	28162770	MONOMAC1	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	0.12044534279661671	[129]	[161]	1	hSpCas9	negative selection	12081570
73211823	73211846	14	+	28162770	MONOMAC1	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	-2.47005534146597	[115]	[23]	-9	hSpCas9	negative selection	12081571
73217179	73217202	14	+	28162770	MONOMAC1	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.8297158805461315	[186]	[380]	7	hSpCas9	negative selection	12081572
73148038	73148061	14	-	28162770	MONOMAC1	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	0.36906662641028665	[76]	[113]	3	hSpCas9	negative selection	12081573
73170813	73170836	14	+	28162770	MONOMAC1	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	0.1710031726821209	[116]	[150]	1	hSpCas9	negative selection	12081574
73173671	73173694	14	-	28162770	MONOMAC1	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	1.7984192277954985	[158]	[633]	9	hSpCas9	negative selection	12081575
73192796	73192819	14	-	28162770	MONOMAC1	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	0.9498045412697174	[69]	[154]	8	hSpCas9	negative selection	12081576
73170889	73170912	14	+	28162770	OCIAML2	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-1.6520766965796931	[54]	[96]	-7	hSpCas9	negative selection	12250933
73211933	73211956	14	-	28162770	OCIAML2	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	0.9163932978670859	[25]	[271]	8	hSpCas9	negative selection	12250934
73170973	73170996	14	+	28162770	OCIAML2	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	-0.27236019810588735	[55]	[256]	-2	hSpCas9	negative selection	12250935
73192815	73192838	14	-	28162770	OCIAML2	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	-0.37948193718396594	[45]	[195]	-3	hSpCas9	negative selection	12250936
73211823	73211846	14	+	28162770	OCIAML2	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	-1.5303360713664291	[36]	[70]	-7	hSpCas9	negative selection	12250937
73217179	73217202	14	+	28162770	OCIAML2	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.00956035356193341	[68]	[384]	0	hSpCas9	negative selection	12250938
73148038	73148061	14	-	28162770	OCIAML2	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	1.2166943931086727	[16]	[218]	9	hSpCas9	negative selection	12250939
73170813	73170836	14	+	28162770	OCIAML2	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	0.17962413573071437	[35]	[225]	1	hSpCas9	negative selection	12250940
73173671	73173694	14	-	28162770	OCIAML2	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.3201422126198388	[49]	[345]	3	hSpCas9	negative selection	12250941
73192796	73192819	14	-	28162770	OCIAML2	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	-0.7019553713486169	[26]	[91]	-5	hSpCas9	negative selection	12250942
73170889	73170912	14	+	28162770	OCIAML3	viability	GCAGGTGGTGGAGCAAGATGAGG	PSEN1	ENSG00000080815	-0.1388130145733366	[92]	[254]	-1	hSpCas9	negative selection	12420299
73211933	73211956	14	-	28162770	OCIAML3	viability	GAAATGCACATACTTTCCTCTGG	PSEN1	ENSG00000080815	-0.30795658176539736	[56]	[138]	-2	hSpCas9	negative selection	12420300
73170973	73170996	14	+	28162770	OCIAML3	viability	TGTGACTCTCTGCATGGTGGTGG	PSEN1	ENSG00000080815	0.8330025006207566	[89]	[483]	7	hSpCas9	negative selection	12420301
73192815	73192838	14	-	28162770	OCIAML3	viability	GCCACGCAGTCCATTCAGGGAGG	PSEN1	ENSG00000080815	0.11025378876933728	[57]	[188]	1	hSpCas9	negative selection	12420302
73211823	73211846	14	+	28162770	OCIAML3	viability	GTGAGGAATGGGAAGCCCAGAGG	PSEN1	ENSG00000080815	0.026144288859293208	[26]	[82]	0	hSpCas9	negative selection	12420303
73217179	73217202	14	+	28162770	OCIAML3	viability	AAAGCCTCAGCAACAGCCAGTGG	PSEN1	ENSG00000080815	0.6499179425619261	[56]	[269]	6	hSpCas9	negative selection	12420304
73148038	73148061	14	-	28162770	OCIAML3	viability	GCATTCTGGAAGTAGGACAACGG	PSEN1	ENSG00000080815	0.45268559512387835	[37]	[156]	4	hSpCas9	negative selection	12420305
73170813	73170836	14	+	28162770	OCIAML3	viability	GGCAGGAGCACAACGACAGACGG	PSEN1	ENSG00000080815	0.45392683673953904	[36]	[152]	4	hSpCas9	negative selection	12420306
73173671	73173694	14	-	28162770	OCIAML3	viability	ATTTATACAGAACCACCAGGAGG	PSEN1	ENSG00000080815	0.06165785174019489	[72]	[229]	0	hSpCas9	negative selection	12420307
73192796	73192819	14	-	28162770	OCIAML3	viability	GAGGTACTTGATAAACACCAGGG	PSEN1	ENSG00000080815	-0.8164000616606112	[27]	[47]	-6	hSpCas9	negative selection	12420308