Crispr

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 5664
  • Symbol: PSEN2
  • Description: presenilin 2
DataSource: http://genomecrispr.dkfz.de/#!/results/PSEN2

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Start The end chr strand pubmed cellline condition sequence symbol ensg log2fc rc_initial rc_final effect cas screentype index
226883704 226883727 1 + 26472758 Jiyoye viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -1.224329705152313 [188] [60] -7 hSpCas9 negative selection 129438
226885554 226885577 1 + 26472758 Jiyoye viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 0.200724504038447 [74] [64] 1 hSpCas9 negative selection 129439
226883874 226883897 1 - 26472758 Jiyoye viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 -0.12007162135899521 [146] [101] -1 hSpCas9 negative selection 129440
226882026 226882049 1 + 26472758 Jiyoye viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 1.6718786077002856 [71] [172] 8 hSpCas9 negative selection 129441
226888867 226888890 1 - 26472758 Jiyoye viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 0.17922343482752479 [129] [110] 1 hSpCas9 negative selection 129442
226888919 226888942 1 - 26472758 Jiyoye viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -1.725274914517776 [170] [38] -8 hSpCas9 negative selection 129443
226890072 226890095 1 + 26472758 Jiyoye viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.8327821224949045 [101] [136] 6 hSpCas9 negative selection 129444
226891315 226891338 1 - 26472758 Jiyoye viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -2.0221362487550882 [236] [43] -8 hSpCas9 negative selection 129445
226883716 226883739 1 + 26472758 Jiyoye viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 3.5771003829481853 [0] [8] 9 hSpCas9 negative selection 129446
226883746 226883769 1 - 26472758 Jiyoye viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.7677650967623408 [80] [103] 5 hSpCas9 negative selection 129447
226883704 226883727 1 + 26472758 KBM7 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -1.1827014342509214 [545,485] [148,68] -7 hSpCas9 negative selection 320556
226885554 226885577 1 + 26472758 KBM7 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 0.8610402510342424 [349,360] [209,390] 8 hSpCas9 negative selection 320557
226883874 226883897 1 - 26472758 KBM7 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 0.17685127788775473 [370,272] [68,258] 1 hSpCas9 negative selection 320558
226882026 226882049 1 + 26472758 KBM7 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.8748247794967587 [488,306] [330,341] 8 hSpCas9 negative selection 320559
226888867 226888890 1 - 26472758 KBM7 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -0.7257934096365906 [698,367] [173,123] -6 hSpCas9 negative selection 320560
226888919 226888942 1 - 26472758 KBM7 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -1.5070521626152202 [598,364] [65,88] -8 hSpCas9 negative selection 320561
226890072 226890095 1 + 26472758 KBM7 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.44836052346802546 [588,282] [307,237] 5 hSpCas9 negative selection 320562
226891315 226891338 1 - 26472758 KBM7 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -0.66228520845897 [532,438] [149,137] -5 hSpCas9 negative selection 320563
226883716 226883739 1 + 26472758 KBM7 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -0.0571295282604698 [25,36] [3,23] 0 hSpCas9 negative selection 320564
226883746 226883769 1 - 26472758 KBM7 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.5393166912479853 [402,444] [318,268] 6 hSpCas9 negative selection 320565
226883704 226883727 1 + 26472758 Raji viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -2.0846352369193295 [328] [17] -8 hSpCas9 negative selection 511674
226885554 226885577 1 + 26472758 Raji viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 0.13059092653492463 [184] [46] 1 hSpCas9 negative selection 511675
226883874 226883897 1 - 26472758 Raji viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 0.15417774685254063 [181] [46] 1 hSpCas9 negative selection 511676
226882026 226882049 1 + 26472758 Raji viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.8409505530779409 [254] [105] 7 hSpCas9 negative selection 511677
226888867 226888890 1 - 26472758 Raji viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -0.3413745817492455 [201] [36] -3 hSpCas9 negative selection 511678
226888919 226888942 1 - 26472758 Raji viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -1.365104236089144 [221] [19] -7 hSpCas9 negative selection 511679
226890072 226890095 1 + 26472758 Raji viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.7203604122643523 [237] [90] 6 hSpCas9 negative selection 511680
226891315 226891338 1 - 26472758 Raji viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -0.7450592762125428 [194] [26] -5 hSpCas9 negative selection 511681
226883716 226883739 1 + 26472758 Raji viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -2.846812775013276 [30] [0] -9 hSpCas9 negative selection 511682
226883746 226883769 1 - 26472758 Raji viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.7252379176521304 [158] [60] 6 hSpCas9 negative selection 511683
226883704 226883727 1 + 26472758 K562 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -1.9427842652077012 [377] [82] -7 hSpCas9 negative selection 702792
226885554 226885577 1 + 26472758 K562 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 1.566346822553809 [289] [724] 9 hSpCas9 negative selection 702793
226883874 226883897 1 - 26472758 K562 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 0.31000706929402355 [300] [314] 2 hSpCas9 negative selection 702794
226882026 226882049 1 + 26472758 K562 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.5397350923064894 [382] [469] 4 hSpCas9 negative selection 702795
226888867 226888890 1 - 26472758 K562 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -2.9525364797450138 [430] [46] -8 hSpCas9 negative selection 702796
226888919 226888942 1 - 26472758 K562 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -2.283318904361759 [345] [59] -8 hSpCas9 negative selection 702797
226890072 226890095 1 + 26472758 K562 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -0.15193420834747018 [357] [271] -1 hSpCas9 negative selection 702798
226891315 226891338 1 - 26472758 K562 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -0.9322636399511741 [320] [141] -5 hSpCas9 negative selection 702799
226883716 226883739 1 + 26472758 K562 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -5.040983491195801 [38] [0] -9 hSpCas9 negative selection 702800
226883746 226883769 1 - 26472758 K562 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.33653692965487825 [454] [484] 2 hSpCas9 negative selection 702801
226881916 226881939 1 + 26627737 DLD1 viability ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 -0.5018295300104989 [506] [83,163,92] -5 hSpCas9 negative selection 769428
226883891 226883914 1 + 26627737 DLD1 viability CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.5042152340830378 [716] [237,404,314] 5 hSpCas9 negative selection 769429
226885594 226885617 1 - 26627737 DLD1 viability CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 -0.05437544549543327 [1159] [499,257,293] 0 hSpCas9 negative selection 769430
226888096 226888119 1 - 26627737 DLD1 viability AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.2818816651138174 [461] [185,75,248] 3 hSpCas9 negative selection 769431
226888838 226888861 1 + 26627737 DLD1 viability CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 -0.263376437988306 [970] [147,440,187] -3 hSpCas9 negative selection 769432
226890072 226890095 1 + 26627737 DLD1 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 5.268302783106524 [3] [49,89,11] 9 hSpCas9 negative selection 769433
226881916 226881939 1 + 26627737 GBM cells viability after 5 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 -0.48531757761198346 [277] [76,135] -6 hSpCas9 negative selection 851743
226883891 226883914 1 + 26627737 GBM cells viability after 5 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 -0.06795934550571969 [817] [376,459] -1 hSpCas9 negative selection 851744
226885594 226885617 1 - 26627737 GBM cells viability after 5 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.6188059556929504 [339] [294,264] 8 hSpCas9 negative selection 851745
226888096 226888119 1 - 26627737 GBM cells viability after 5 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.4447379816998836 [273] [185,213] 6 hSpCas9 negative selection 851746
226888838 226888861 1 + 26627737 GBM cells viability after 5 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.3929796203297999 [332] [245,222] 6 hSpCas9 negative selection 851747
226890072 226890095 1 + 26627737 GBM cells viability after 5 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -0.48810924822356183 [67] [18,32] -6 hSpCas9 negative selection 851748
226881916 226881939 1 + 26627737 GBM cells viability after 13 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.10484438008334565 [277] [159,163] 1 hSpCas9 negative selection 934058
226883891 226883914 1 + 26627737 GBM cells viability after 13 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.12239878944890825 [817] [604,383] 1 hSpCas9 negative selection 934059
226885594 226885617 1 - 26627737 GBM cells viability after 13 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.5657024535192035 [339] [368,194] 7 hSpCas9 negative selection 934060
226888096 226888119 1 - 26627737 GBM cells viability after 13 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.6663994100599597 [273] [273,204] 7 hSpCas9 negative selection 934061
226888838 226888861 1 + 26627737 GBM cells viability after 13 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.31980246141122765 [332] [294,168] 4 hSpCas9 negative selection 934062
226890072 226890095 1 + 26627737 GBM cells viability after 13 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -0.6107057939721572 [67] [0,42] -6 hSpCas9 negative selection 934063
226881916 226881939 1 + 26627737 GBM cells viability after 21 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 -0.3534859370603397 [277] [124,111] -3 hSpCas9 negative selection 1016373
226883891 226883914 1 + 26627737 GBM cells viability after 21 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.1464323344129188 [817] [482,499] 1 hSpCas9 negative selection 1016374
226885594 226885617 1 - 26627737 GBM cells viability after 21 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.35199032151471893 [339] [217,251] 3 hSpCas9 negative selection 1016375
226888096 226888119 1 - 26627737 GBM cells viability after 21 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.6796433472342287 [273] [239,236] 7 hSpCas9 negative selection 1016376
226888838 226888861 1 + 26627737 GBM cells viability after 21 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.2972190706840238 [332] [226,217] 3 hSpCas9 negative selection 1016377
226890072 226890095 1 + 26627737 GBM cells viability after 21 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.16549044380928546 [67] [42,39] 1 hSpCas9 negative selection 1016378
226881916 226881939 1 + 26627737 RPE1 viability after 9 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.41073057245491684 [664] [126,469] 3 hSpCas9 negative selection 1098688
226883891 226883914 1 + 26627737 RPE1 viability after 9 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 1.1162913209761895 [1539] [925,1198] 6 hSpCas9 negative selection 1098689
226885594 226885617 1 - 26627737 RPE1 viability after 9 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 -0.04659463325500712 [1907] [473,712] 0 hSpCas9 negative selection 1098690
226888096 226888119 1 - 26627737 RPE1 viability after 9 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.24482714985600645 [707] [118,447] 1 hSpCas9 negative selection 1098691
226888838 226888861 1 + 26627737 RPE1 viability after 9 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.7891139708060342 [750] [359,465] 5 hSpCas9 negative selection 1098692
226890072 226890095 1 + 26627737 RPE1 viability after 9 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -2.513022587262669 [471] [0,57] -9 hSpCas9 negative selection 1098693
226881916 226881939 1 + 26627737 RPE1 viability after 12 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 -0.05411559207738778 [664] [157,186] 0 hSpCas9 negative selection 1181003
226883891 226883914 1 + 26627737 RPE1 viability after 12 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 1.3379850959242967 [1539] [992,1101] 7 hSpCas9 negative selection 1181004
226885594 226885617 1 - 26627737 RPE1 viability after 12 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.16640079055577606 [1907] [567,582] 1 hSpCas9 negative selection 1181005
226888096 226888119 1 - 26627737 RPE1 viability after 12 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.08630916919679063 [707] [148,257] 0 hSpCas9 negative selection 1181006
226888838 226888861 1 + 26627737 RPE1 viability after 12 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 1.252821129253944 [750] [457,504] 7 hSpCas9 negative selection 1181007
226890072 226890095 1 + 26627737 RPE1 viability after 12 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -3.0714205352752164 [471] [0,29] -9 hSpCas9 negative selection 1181008
226881916 226881939 1 + 26627737 RPE1 viability after 15 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 -0.7993959631559078 [664] [74,139] -5 hSpCas9 negative selection 1263318
226883891 226883914 1 + 26627737 RPE1 viability after 15 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 1.3190173136866528 [1539] [1233,944] 7 hSpCas9 negative selection 1263319
226885594 226885617 1 - 26627737 RPE1 viability after 15 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.04900710962518495 [1907] [536,578] 0 hSpCas9 negative selection 1263320
226888096 226888119 1 - 26627737 RPE1 viability after 15 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.1978725703151034 [707] [132,322] 1 hSpCas9 negative selection 1263321
226888838 226888861 1 + 26627737 RPE1 viability after 15 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 1.4260722566440636 [750] [409,725] 7 hSpCas9 negative selection 1263322
226890072 226890095 1 + 26627737 RPE1 viability after 15 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -2.8269492182007725 [471] [0,35] -9 hSpCas9 negative selection 1263323
226881916 226881939 1 + 26627737 RPE1 viability after 18 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 -0.0022757039854002237 [664] [198,157] 0 hSpCas9 negative selection 1345633
226883891 226883914 1 + 26627737 RPE1 viability after 18 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 1.4074328390573214 [1539] [1187,1010] 7 hSpCas9 negative selection 1345634
226885594 226885617 1 - 26627737 RPE1 viability after 18 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.07596366527476128 [1907] [447,643] 0 hSpCas9 negative selection 1345635
226888096 226888119 1 - 26627737 RPE1 viability after 18 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.6144607116885068 [707] [263,322] 4 hSpCas9 negative selection 1345636
226888838 226888861 1 + 26627737 RPE1 viability after 18 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 1.3871315014434387 [750] [401,666] 7 hSpCas9 negative selection 1345637
226890072 226890095 1 + 26627737 RPE1 viability after 18 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -2.717247449947625 [471] [0,38] -9 hSpCas9 negative selection 1345638
226881916 226881939 1 + 26627737 HeLa viability after 8 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 -0.022779183775477663 [304] [182,112,108] 0 hSpCas9 negative selection 1427948
226883891 226883914 1 + 26627737 HeLa viability after 8 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 -0.35242927368477783 [1400] [689,470,328] -3 hSpCas9 negative selection 1427949
226885594 226885617 1 - 26627737 HeLa viability after 8 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.66507549255193 [645] [444,549,348] 6 hSpCas9 negative selection 1427950
226888096 226888119 1 - 26627737 HeLa viability after 8 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.444785893116559 [375] [259,218,198] 4 hSpCas9 negative selection 1427951
226888838 226888861 1 + 26627737 HeLa viability after 8 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.9491549818048377 [329] [124,288,376] 7 hSpCas9 negative selection 1427952
226890072 226890095 1 + 26627737 HeLa viability after 8 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -0.9992569897872627 [73] [24,4,19] -7 hSpCas9 negative selection 1427953
226881916 226881939 1 + 26627737 HeLa viability after 12 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.7485615179114634 [304] [280,195,161] 6 hSpCas9 negative selection 1510263
226883891 226883914 1 + 26627737 HeLa viability after 12 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 -0.5585097484919306 [1400] [426,358,397] -5 hSpCas9 negative selection 1510264
226885594 226885617 1 - 26627737 HeLa viability after 12 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.6836277986875858 [645] [364,499,411] 5 hSpCas9 negative selection 1510265
226888096 226888119 1 - 26627737 HeLa viability after 12 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 -0.4383255597400961 [375] [50,87,205] -4 hSpCas9 negative selection 1510266
226888838 226888861 1 + 26627737 HeLa viability after 12 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 1.2149177067239043 [329] [672,52,261] 8 hSpCas9 negative selection 1510267
226890072 226890095 1 + 26627737 HeLa viability after 12 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.2204966850129959 [73] [84,0,25] 2 hSpCas9 negative selection 1510268
226881916 226881939 1 + 26627737 HeLa viability after 15 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.5235646373871605 [304] [107,338,81] 4 hSpCas9 negative selection 1592578
226883891 226883914 1 + 26627737 HeLa viability after 15 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 -0.6200063805225697 [1400] [410,412,281] -5 hSpCas9 negative selection 1592579
226885594 226885617 1 - 26627737 HeLa viability after 15 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.9659900810173596 [645] [388,576,581] 7 hSpCas9 negative selection 1592580
226888096 226888119 1 - 26627737 HeLa viability after 15 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 -0.4918245257580771 [375] [17,100,216] -4 hSpCas9 negative selection 1592581
226888838 226888861 1 + 26627737 HeLa viability after 15 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 1.7717833237903897 [329] [724,198,447] 9 hSpCas9 negative selection 1592582
226890072 226890095 1 + 26627737 HeLa viability after 15 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -1.0953928712122893 [73] [36,2,0] -7 hSpCas9 negative selection 1592583
226881916 226881939 1 + 26627737 HeLa viability after 18 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.5167962338439098 [304] [68,282,81] 4 hSpCas9 negative selection 1674893
226883891 226883914 1 + 26627737 HeLa viability after 18 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 -0.5937602950162975 [1400] [292,336,281] -5 hSpCas9 negative selection 1674894
226885594 226885617 1 - 26627737 HeLa viability after 18 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.9575585234238313 [645] [250,482,581] 7 hSpCas9 negative selection 1674895
226888096 226888119 1 - 26627737 HeLa viability after 18 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 -0.4957947185448661 [375] [15,77,216] -4 hSpCas9 negative selection 1674896
226888838 226888861 1 + 26627737 HeLa viability after 18 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 1.7826179658328947 [329] [492,164,447] 9 hSpCas9 negative selection 1674897
226890072 226890095 1 + 26627737 HeLa viability after 18 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -1.0142376167696847 [73] [25,2,0] -7 hSpCas9 negative selection 1674898
226881916 226881939 1 + 26627737 HCT116 viability after 6 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 1.1598700873937604 [284] [248,17] 6 hSpCas9 negative selection 1757208
226883891 226883914 1 + 26627737 HCT116 viability after 6 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 -0.23222373334344992 [1426] [170,201] -1 hSpCas9 negative selection 1757209
226885594 226885617 1 - 26627737 HCT116 viability after 6 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.4042973441984463 [1802] [436,340] 2 hSpCas9 negative selection 1757210
226888096 226888119 1 - 26627737 HCT116 viability after 6 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 -0.7200453873384066 [888] [89,81] -4 hSpCas9 negative selection 1757211
226888838 226888861 1 + 26627737 HCT116 viability after 6 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.6084686941171803 [1143] [415,195] 3 hSpCas9 negative selection 1757212
226890072 226890095 1 + 26627737 HCT116 viability after 6 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.7625250490573494 [10] [0,3] 4 hSpCas9 negative selection 1757213
226881916 226881939 1 + 26627737 HCT116 viability after 8 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.13545946219802166 [248] [269,93,90] 1 hSpCas9 negative selection 1839523
226883891 226883914 1 + 26627737 HCT116 viability after 8 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.19171127819759026 [787] [413,469,600] 2 hSpCas9 negative selection 1839524
226885594 226885617 1 - 26627737 HCT116 viability after 8 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 -0.0968527586346456 [531] [259,280,280] -1 hSpCas9 negative selection 1839525
226888096 226888119 1 - 26627737 HCT116 viability after 8 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.03941003590287967 [413] [210,264,226] 0 hSpCas9 negative selection 1839526
226888838 226888861 1 + 26627737 HCT116 viability after 8 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 -0.05361986855646439 [565] [311,312,276] 0 hSpCas9 negative selection 1839527
226890072 226890095 1 + 26627737 HCT116 viability after 8 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 1.0209603342178606 [25] [11,52,21] 8 hSpCas9 negative selection 1839528
226881916 226881939 1 + 26627737 HCT116 viability after 9 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.6329248936673735 [284] [260,4] 4 hSpCas9 negative selection 1921838
226883891 226883914 1 + 26627737 HCT116 viability after 9 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.26528208159241107 [1426] [424,483] 2 hSpCas9 negative selection 1921839
226885594 226885617 1 - 26627737 HCT116 viability after 9 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 -1.274177425784611 [1802] [250,157] -7 hSpCas9 negative selection 1921840
226888096 226888119 1 - 26627737 HCT116 viability after 9 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.14994330704000114 [888] [316,220] 1 hSpCas9 negative selection 1921841
226888838 226888861 1 + 26627737 HCT116 viability after 9 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 -0.23336378315204898 [1143] [370,171] -2 hSpCas9 negative selection 1921842
226890072 226890095 1 + 26627737 HCT116 viability after 9 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 3.226208790944722 [10] [60,0] 9 hSpCas9 negative selection 1921843
226881916 226881939 1 + 26627737 HCT116 viability after 12 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.18119435533581574 [248] [256,83,92] 2 hSpCas9 negative selection 2004153
226883891 226883914 1 + 26627737 HCT116 viability after 12 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 -0.18763711545963813 [787] [355,342,391] -2 hSpCas9 negative selection 2004154
226885594 226885617 1 - 26627737 HCT116 viability after 12 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.645800954095534 [531] [379,381,553] 6 hSpCas9 negative selection 2004155
226888096 226888119 1 - 26627737 HCT116 viability after 12 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 -0.10386553373645141 [413] [213,187,203] -1 hSpCas9 negative selection 2004156
226888838 226888861 1 + 26627737 HCT116 viability after 12 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.031326333451204835 [565] [304,227,376] 0 hSpCas9 negative selection 2004157
226890072 226890095 1 + 26627737 HCT116 viability after 12 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.6930415046051519 [25] [28,35,0] 6 hSpCas9 negative selection 2004158
226881916 226881939 1 + 26627737 HCT116 viability after 15 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.2994155460750765 [248] [205,99,224] 3 hSpCas9 negative selection 2086468
226883891 226883914 1 + 26627737 HCT116 viability after 15 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.2931742226215508 [787] [915,274,516] 3 hSpCas9 negative selection 2086469
226885594 226885617 1 - 26627737 HCT116 viability after 15 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.5188173390493084 [531] [329,437,530] 5 hSpCas9 negative selection 2086470
226888096 226888119 1 - 26627737 HCT116 viability after 15 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 -0.2855247656938985 [413] [282,125,186] -3 hSpCas9 negative selection 2086471
226888838 226888861 1 + 26627737 HCT116 viability after 15 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 -0.247116292401247 [565] [310,227,286] -3 hSpCas9 negative selection 2086472
226890072 226890095 1 + 26627737 HCT116 viability after 15 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.9997245886885366 [25] [41,14,33] 8 hSpCas9 negative selection 2086473
226881916 226881939 1 + 26627737 HCT116 viability after 18 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.18214476584194778 [248] [283,30,99] 1 hSpCas9 negative selection 2168783
226883891 226883914 1 + 26627737 HCT116 viability after 18 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 -0.1649651684507456 [787] [317,334,367] -1 hSpCas9 negative selection 2168784
226885594 226885617 1 - 26627737 HCT116 viability after 18 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 1.2514370479483783 [531] [536,548,761] 8 hSpCas9 negative selection 2168785
226888096 226888119 1 - 26627737 HCT116 viability after 18 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.20995905346056482 [413] [143,228,325] 1 hSpCas9 negative selection 2168786
226888838 226888861 1 + 26627737 HCT116 viability after 18 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.0574792401612052 [565] [232,196,436] 0 hSpCas9 negative selection 2168787
226890072 226890095 1 + 26627737 HCT116 viability after 18 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -0.3991804384279045 [25] [0,0,27] -4 hSpCas9 negative selection 2168788
226881916 226881939 1 + 24336569 HL60 viability ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.5291343270791091 [501] [1532] 5 hSpCas9 negative selection 2286902
226881924 226881947 1 - 24336569 HL60 viability CACTTCTTCCTCGCTGTCAGAGG PSEN2 ENSG00000143801 -0.24471085578409135 [228] [408] -2 hSpCas9 negative selection 2286903
226881936 226881959 1 + 24336569 HL60 viability AGGAAGAAGTGTGTGATGAGCGG PSEN2 ENSG00000143801 1.1254982801379456 [234] [1084] 8 hSpCas9 negative selection 2286904
226881952 226881975 1 + 24336569 HL60 viability TGAGCGGACGTCCCTAATGTCGG PSEN2 ENSG00000143801 0.09576866155491678 [546] [1236] 0 hSpCas9 negative selection 2286905
226881983 226882006 1 - 24336569 HL60 viability TCCTGGCAGGAGCGCGGCGTGGG PSEN2 ENSG00000143801 1.2297375876654075 [134] [669] 8 hSpCas9 negative selection 2286906
226881989 226882012 1 - 24336569 HL60 viability CTGCCCTCCTGGCAGGAGCGCGG PSEN2 ENSG00000143801 -0.41626754060788446 [407] [646] -4 hSpCas9 negative selection 2286907
226881994 226882017 1 + 24336569 HL60 viability CTCCTGCCAGGAGGGCAGGCAGG PSEN2 ENSG00000143801 -2.000240305354924 [258] [136] -9 hSpCas9 negative selection 2286908
226882003 226882026 1 + 24336569 HL60 viability GGAGGGCAGGCAGGGCCCAGAGG PSEN2 ENSG00000143801 -1.090528183057133 [478] [475] -7 hSpCas9 negative selection 2286909
226882018 226882041 1 - 24336569 HL60 viability CAGTGTTCTCTCCATCCTCTGGG PSEN2 ENSG00000143801 -0.2963496706376371 [606] [1045] -3 hSpCas9 negative selection 2286910
226882026 226882049 1 + 24336569 HL60 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.6652280395220835 [339] [1140] 5 hSpCas9 negative selection 2286911
226881916 226881939 1 + 24336569 KBM7 viability ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.6537364834473178 [566] [2432] 6 hSpCas9 negative selection 2354079
226881924 226881947 1 - 24336569 KBM7 viability CACTTCTTCCTCGCTGTCAGAGG PSEN2 ENSG00000143801 1.1057951922723317 [176] [1038] 8 hSpCas9 negative selection 2354080
226881936 226881959 1 + 24336569 KBM7 viability AGGAAGAAGTGTGTGATGAGCGG PSEN2 ENSG00000143801 -0.11462407951249624 [390] [984] -1 hSpCas9 negative selection 2354081
226881952 226881975 1 + 24336569 KBM7 viability TGAGCGGACGTCCCTAATGTCGG PSEN2 ENSG00000143801 -0.32924592754384197 [426] [926] -3 hSpCas9 negative selection 2354082
226881983 226882006 1 - 24336569 KBM7 viability TCCTGGCAGGAGCGCGGCGTGGG PSEN2 ENSG00000143801 -0.08410883941833669 [88] [228] 0 hSpCas9 negative selection 2354083
226881989 226882012 1 - 24336569 KBM7 viability CTGCCCTCCTGGCAGGAGCGCGG PSEN2 ENSG00000143801 1.1184489462658542 [293] [1740] 8 hSpCas9 negative selection 2354084
226881994 226882017 1 + 24336569 KBM7 viability CTCCTGCCAGGAGGGCAGGCAGG PSEN2 ENSG00000143801 0.20750939056291595 [173] [547] 2 hSpCas9 negative selection 2354085
226882003 226882026 1 + 24336569 KBM7 viability GGAGGGCAGGCAGGGCCCAGAGG PSEN2 ENSG00000143801 -2.420842814076755 [694] [353] -8 hSpCas9 negative selection 2354086
226882018 226882041 1 - 24336569 KBM7 viability CAGTGTTCTCTCCATCCTCTGGG PSEN2 ENSG00000143801 -1.2983409061216862 [678] [752] -7 hSpCas9 negative selection 2354087
226882026 226882049 1 + 24336569 KBM7 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.1594770750228903 [431] [1315] 1 hSpCas9 negative selection 2354088
226884835 226884858 1 - 25494202 A375 resistance to PLX-4720 (puromycin) TCACTGCAGCCTCGACTTCTGGG PSEN2 ENSG00000143801 -0.3334344553746127 [914,176] [125,59] -1 dCas9-VP64 positive selection 2383766
226870401 226870424 1 - 25494202 A375 resistance to PLX-4720 (puromycin) CCTTAGAAGGAGTGGAGGCCGGG PSEN2 ENSG00000143801 -2.9599959871179795 [305,32] [5,1] -9 dCas9-VP64 positive selection 2384022
226870425 226870448 1 + 25494202 A375 resistance to PLX-4720 (puromycin) CGTCGCTTAGTTCCGACGTCGGG PSEN2 ENSG00000143801 2.2550078553699837 [34,39] [18,61] 7 dCas9-VP64 positive selection 2384023
226870453 226870476 1 - 25494202 A375 resistance to PLX-4720 (puromycin) CTTCACGCCGCGTGGATGACAGG PSEN2 ENSG00000143801 -0.033851734106017606 [5,31] [0,6] 0 dCas9-VP64 positive selection 2384024
226884835 226884858 1 - 25494202 A375 resistance to PLX-4720 (zeocin) TCACTGCAGCCTCGACTTCTGGG PSEN2 ENSG00000143801 -0.34054073104189286 [370,392] [107,88] -3 dCas9-VP64 positive selection 2479021
226870401 226870424 1 - 25494202 A375 resistance to PLX-4720 (zeocin) CCTTAGAAGGAGTGGAGGCCGGG PSEN2 ENSG00000143801 -0.2160261772066231 [79,52] [16,18] -2 dCas9-VP64 positive selection 2479277
226870425 226870448 1 + 25494202 A375 resistance to PLX-4720 (zeocin) CGTCGCTTAGTTCCGACGTCGGG PSEN2 ENSG00000143801 -0.2116324272541188 [11,67] [7,13] -2 dCas9-VP64 positive selection 2479278
226870453 226870476 1 - 25494202 A375 resistance to PLX-4720 (zeocin) CTTCACGCCGCGTGGATGACAGG PSEN2 ENSG00000143801 -1.0784731755910302 [112,69] [14,12] -8 dCas9-VP64 positive selection 2479279
226885659 226885682 1 + 27453484 HT29 resistance to T3SS1-dependent cytotoxicity CTACAAGTACCGCTGCTACAAGG PSEN2 ENSG00000143801 0.07288249190718538 [5,5] [4,4] 1 hSpCas9 positive selection 3014221
226888878 226888901 1 + 27453484 HT29 resistance to T3SS1-dependent cytotoxicity GCTGACTGTCTGGAACTTCGGGG PSEN2 ENSG00000143801 -0.010647175107206391 [3,3] [2,3] 0 hSpCas9 positive selection 3014222
226883755 226883778 1 + 27453484 HT29 resistance to T3SS1-dependent cytotoxicity TCTGTAGTGGGGTTCCCGGGCGG PSEN2 ENSG00000143801 -0.13463457714819535 [3,3] [1,3] -2 hSpCas9 positive selection 3014223
226883744 226883767 1 + 27453484 HT29 resistance to T3SS1-dependent cytotoxicity TGACCGCTATGTCTGTAGTGGGG PSEN2 ENSG00000143801 0.1524931303541458 [5,5] [4,4] 3 hSpCas9 positive selection 3014224
226885659 226885682 1 + 27453484 HT29 resistance to T3SS2-dependent cytotoxicity CTACAAGTACCGCTGCTACAAGG PSEN2 ENSG00000143801 0.14646608195128724 [5,5] [6,2] 2 hSpCas9 positive selection 3082079
226888878 226888901 1 + 27453484 HT29 resistance to T3SS2-dependent cytotoxicity GCTGACTGTCTGGAACTTCGGGG PSEN2 ENSG00000143801 -0.27939573584901956 [3,3] [3,0] -4 hSpCas9 positive selection 3082080
226883755 226883778 1 + 27453484 HT29 resistance to T3SS2-dependent cytotoxicity TCTGTAGTGGGGTTCCCGGGCGG PSEN2 ENSG00000143801 -0.011038107485599566 [3,3] [2,2] 0 hSpCas9 positive selection 3082081
226883744 226883767 1 + 27453484 HT29 resistance to T3SS2-dependent cytotoxicity TGACCGCTATGTCTGTAGTGGGG PSEN2 ENSG00000143801 0.44748746645065723 [5,5] [8,2] 7 hSpCas9 positive selection 3082082
226888096 226888119 - 24336571 A375 resistance to PLX after 7 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 -0.05557406986989466 [20,17] [18,17] -1 hSpCas9 positive selection 3138296
226889004 226889027 - 24336571 A375 resistance to PLX after 7 days ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.07703715870023298 [39,39] [34,39] -2 hSpCas9 positive selection 3138297
226888958 226888981 + 24336571 A375 resistance to PLX after 7 days CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.0103184818863844 [33,28] [30,30] 0 hSpCas9 positive selection 3138298
226888136 226888159 + 24336571 A375 resistance to PLX after 7 days CTCTTCACCTATATCTACCTTGG PSEN2 ENSG00000143801 0.08440807543799744 [26,27] [28,27] 3 hSpCas9 positive selection 3138299
226888990 226889013 + 24336571 A375 resistance to PLX after 7 days TCATCAAGTACCTCCCAGAGTGG PSEN2 ENSG00000143801 -0.20113327680168958 [14,16] [15,11] -6 hSpCas9 positive selection 3138300
226888083 226888106 + 24336571 A375 resistance to PLX after 7 days TTGTCTAGTTCATCCATGGCTGG PSEN2 ENSG00000143801 0.020036380184207614 [30,21] [26,25] 0 hSpCas9 positive selection 3138301
226888096 226888119 - 24336571 A375 resistance to PLX after 14 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 -0.28574191599035736 [20,21] [5,9] -3 hSpCas9 positive selection 3196089
226889004 226889027 - 24336571 A375 resistance to PLX after 14 days ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.4018902212261357 [48,28] [10,15] -5 hSpCas9 positive selection 3196090
226888958 226888981 + 24336571 A375 resistance to PLX after 14 days CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 -0.17965487485237586 [27,26] [9,11] -2 hSpCas9 positive selection 3196091
226888136 226888159 + 24336571 A375 resistance to PLX after 14 days CTCTTCACCTATATCTACCTTGG PSEN2 ENSG00000143801 -0.5410741619695824 [26,21] [7,6] -6 hSpCas9 positive selection 3196092
226888990 226889013 + 24336571 A375 resistance to PLX after 14 days TCATCAAGTACCTCCCAGAGTGG PSEN2 ENSG00000143801 -0.5492362254268566 [15,17] [4,4] -6 hSpCas9 positive selection 3196093
226888083 226888106 + 24336571 A375 resistance to PLX after 14 days TTGTCTAGTTCATCCATGGCTGG PSEN2 ENSG00000143801 -0.08312116497604882 [35,25] [12,13] -1 hSpCas9 positive selection 3196094
226888096 226888119 - 24336571 A375 viability after 7 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.034618667116672164 [19] [20,17] 0 hSpCas9 negative selection 3253882
226889004 226889027 - 24336571 A375 viability after 7 days ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.5008856940171973 [28] [39,39] 7 hSpCas9 negative selection 3253883
226888958 226888981 + 24336571 A375 viability after 7 days CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.1632789849631313 [28] [33,28] 2 hSpCas9 negative selection 3253884
226888136 226888159 + 24336571 A375 viability after 7 days CTCTTCACCTATATCTACCTTGG PSEN2 ENSG00000143801 -0.5525261249589537 [41] [26,27] -7 hSpCas9 negative selection 3253885
226888990 226889013 + 24336571 A375 viability after 7 days TCATCAAGTACCTCCCAGAGTGG PSEN2 ENSG00000143801 0.13983127837137005 [14] [14,16] 2 hSpCas9 negative selection 3253886
226888083 226888106 + 24336571 A375 viability after 7 days TTGTCTAGTTCATCCATGGCTGG PSEN2 ENSG00000143801 0.20278281587141422 [23] [30,21] 3 hSpCas9 negative selection 3253887
226888096 226888119 - 24336571 A375 viability after 14 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.17140728561279106 [19] [20,21] 2 hSpCas9 negative selection 3311675
226889004 226889027 - 24336571 A375 viability after 14 days ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.49639660424319265 [28] [48,28] 6 hSpCas9 negative selection 3311676
226888958 226888981 + 24336571 A375 viability after 14 days CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 -0.014833061189835517 [28] [27,26] 0 hSpCas9 negative selection 3311677
226888136 226888159 + 24336571 A375 viability after 14 days CTCTTCACCTATATCTACCTTGG PSEN2 ENSG00000143801 -0.6835802209545297 [41] [26,21] -7 hSpCas9 negative selection 3311678
226888990 226889013 + 24336571 A375 viability after 14 days TCATCAAGTACCTCCCAGAGTGG PSEN2 ENSG00000143801 0.26245946480408766 [14] [15,17] 3 hSpCas9 negative selection 3311679
226888083 226888106 + 24336571 A375 viability after 14 days TTGTCTAGTTCATCCATGGCTGG PSEN2 ENSG00000143801 0.4445598712817016 [23] [35,25] 5 hSpCas9 negative selection 3311680
226889004 226889027 1 - 27383988 293T resistance to West Nile virus (flavivirus) ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.8143827155971068 [86,86] [0,0] 4 hSpCas9 positive selection 3387897
226894023 226894046 1 - 27383988 293T resistance to West Nile virus (flavivirus) TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 0.057653866609470694 [146,146] [0,0] 0 hSpCas9 positive selection 3387898
226894000 226894023 1 + 27383988 293T resistance to West Nile virus (flavivirus) CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.47596649792117546 [109,109] [0,0] 2 hSpCas9 positive selection 3387899
226885658 226885681 1 + 26780180 HT29 viability (Avana library 4 designs) CTACAAGTACCGCTGCTACAAGG PSEN2 ENSG00000143801 -0.151081203822979 [] [] -2 hSpCas9 negative selection 3452449
226888877 226888900 1 + 26780180 HT29 viability (Avana library 4 designs) GCTGACTGTCTGGAACTTCGGGG PSEN2 ENSG00000143801 -0.399235433596112 [] [] -6 hSpCas9 negative selection 3452450
226883754 226883777 1 + 26780180 HT29 viability (Avana library 4 designs) TCTGTAGTGGGGTTCCCGGGCGG PSEN2 ENSG00000143801 0.825237318797816 [] [] 3 hSpCas9 negative selection 3452451
226883743 226883766 1 + 26780180 HT29 viability (Avana library 4 designs) TGACCGCTATGTCTGTAGTGGGG PSEN2 ENSG00000143801 0.069687866314955 [] [] 0 hSpCas9 negative selection 3452452
226883754 226883777 1 + 26780180 A375 viability (Avana lentiCRISPRv2) TCTGTAGTGGGGTTCCCGGGCGG PSEN2 ENSG00000143801 4.05219938445044 [] [] 6 hSpCas9 negative selection 3548830
226885658 226885681 1 + 26780180 A375 viability (Avana lentiCRISPRv2) CTACAAGTACCGCTGCTACAAGG PSEN2 ENSG00000143801 2.25721915996648 [] [] 3 hSpCas9 negative selection 3548831
226888877 226888900 1 + 26780180 A375 viability (Avana lentiCRISPRv2) GCTGACTGTCTGGAACTTCGGGG PSEN2 ENSG00000143801 0.601434971587103 [] [] 0 hSpCas9 negative selection 3548832
226883743 226883766 1 + 26780180 A375 viability (Avana lentiCRISPRv2) TGACCGCTATGTCTGTAGTGGGG PSEN2 ENSG00000143801 3.51605254596461 [] [] 5 hSpCas9 negative selection 3548833
226885606 226885629 1 - 26780180 A375 viability (Avana lentiCRISPRv2) GATGACGCTGATCATGATGAGGG PSEN2 ENSG00000143801 1.97246472010017 [] [] 3 hSpCas9 negative selection 3548834
226883704 226883727 1 + 26780180 A375 viability (Avana lentiCRISPRv2) GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -6.18253701050725 [] [] -6 hSpCas9 negative selection 3548835
226883754 226883777 1 + 26780180 A375 viability (Avana lentiGuide) TCTGTAGTGGGGTTCCCGGGCGG PSEN2 ENSG00000143801 4.06138532853961 [] [] 4 hSpCas9 negative selection 3657489
226885658 226885681 1 + 26780180 A375 viability (Avana lentiGuide) CTACAAGTACCGCTGCTACAAGG PSEN2 ENSG00000143801 -6.07191129959329 [] [] -8 hSpCas9 negative selection 3657490
226888877 226888900 1 + 26780180 A375 viability (Avana lentiGuide) GCTGACTGTCTGGAACTTCGGGG PSEN2 ENSG00000143801 6.90658087131739 [] [] 5 hSpCas9 negative selection 3657491
226883743 226883766 1 + 26780180 A375 viability (Avana lentiGuide) TGACCGCTATGTCTGTAGTGGGG PSEN2 ENSG00000143801 0.467104426523905 [] [] 0 hSpCas9 negative selection 3657492
226885606 226885629 1 - 26780180 A375 viability (Avana lentiGuide) GATGACGCTGATCATGATGAGGG PSEN2 ENSG00000143801 3.5536262091423 [] [] 3 hSpCas9 negative selection 3657493
226883704 226883727 1 + 26780180 A375 viability (Avana lentiGuide) GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 15.8361209729908 [] [] 8 hSpCas9 negative selection 3657494
226883754 226883777 1 + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) TCTGTAGTGGGGTTCCCGGGCGG PSEN2 ENSG00000143801 0.3572397434278654 [4] [5,5] 9 hSpCas9 positive selection 3766096
226885658 226885681 1 + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) CTACAAGTACCGCTGCTACAAGG PSEN2 ENSG00000143801 -0.008802440106801285 [6] [6,5] 0 hSpCas9 positive selection 3766097
226888877 226888900 1 + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) GCTGACTGTCTGGAACTTCGGGG PSEN2 ENSG00000143801 0.05356511540559426 [4] [4,4] 1 hSpCas9 positive selection 3766098
226883743 226883766 1 + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) TGACCGCTATGTCTGTAGTGGGG PSEN2 ENSG00000143801 0.2051290846618723 [6] [7,7] 6 hSpCas9 positive selection 3766099
226885606 226885629 1 - 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) GATGACGCTGATCATGATGAGGG PSEN2 ENSG00000143801 0.12127101006209529 [6] [7,7] 3 hSpCas9 positive selection 3766100
226883704 226883727 1 + 26780180 A375 resistance to vemurafenib (Avana lentiCRISPRv2) GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -0.27827915517717083 [5] [4,3] -4 hSpCas9 positive selection 3766101
226883754 226883777 1 + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) TCTGTAGTGGGGTTCCCGGGCGG PSEN2 ENSG00000143801 0.04415557194153726 [5] [4,4] 0 hSpCas9 positive selection 3874703
226885658 226885681 1 + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) CTACAAGTACCGCTGCTACAAGG PSEN2 ENSG00000143801 0.22276872009621307 [6] [8,5] 6 hSpCas9 positive selection 3874704
226888877 226888900 1 + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) GCTGACTGTCTGGAACTTCGGGG PSEN2 ENSG00000143801 0.11754697995317652 [5] [5,3] 2 hSpCas9 positive selection 3874705
226883743 226883766 1 + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) TGACCGCTATGTCTGTAGTGGGG PSEN2 ENSG00000143801 0.11098572416628899 [6] [6,5] 2 hSpCas9 positive selection 3874706
226885606 226885629 1 - 26780180 A375 resistance to vemurafenib (Avana lentiGuide) GATGACGCTGATCATGATGAGGG PSEN2 ENSG00000143801 0.12414742547177465 [7] [6,6] 3 hSpCas9 positive selection 3874707
226883704 226883727 1 + 26780180 A375 resistance to vemurafenib (Avana lentiGuide) GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -0.8522453927881034 [6] [3,0] -8 hSpCas9 positive selection 3874708
226883843 226883866 1 - 26780180 A375 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 0.88462769834596 [] [] 4 hSpCas9 negative selection 3985140
226889004 226889027 1 - 26780180 A375 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 1.45232737239061 [] [] 8 hSpCas9 negative selection 3985141
226894000 226894023 1 + 26780180 A375 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 1.023783170507 [] [] 5 hSpCas9 negative selection 3985142
226888958 226888981 1 + 26780180 A375 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 1.62694883925943 [] [] 8 hSpCas9 negative selection 3985143
226883803 226883826 1 - 26780180 A375 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.224809842660875 [] [] 0 hSpCas9 negative selection 3985144
226894023 226894046 1 - 26780180 A375 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 1.11235416257897 [] [] 5 hSpCas9 negative selection 3985145
226883843 226883866 1 - 26780180 HT29 viability (GeCKOv2 library) ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 2.08644991587415 [] [] 9 hSpCas9 negative selection 4093106
226889004 226889027 1 - 26780180 HT29 viability (GeCKOv2 library) ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.810020950728025 [] [] 3 hSpCas9 negative selection 4093107
226894000 226894023 1 + 26780180 HT29 viability (GeCKOv2 library) CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 1.1724348870852 [] [] 5 hSpCas9 negative selection 4093108
226888958 226888981 1 + 26780180 HT29 viability (GeCKOv2 library) CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.944416894424158 [] [] 4 hSpCas9 negative selection 4093109
226883803 226883826 1 - 26780180 HT29 viability (GeCKOv2 library) CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.142151872254772 [] [] 0 hSpCas9 negative selection 4093110
226894023 226894046 1 - 26780180 HT29 viability (GeCKOv2 library) TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 1.11555345464779 [] [] 5 hSpCas9 negative selection 4093111
226888096 226888119 1 - 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.04967109463499968 [3] [2,2] 1 hSpCas9 positive selection 4163512
226889004 226889027 1 - 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.24593886687055344 [5] [4,3] 6 hSpCas9 positive selection 4163513
226888958 226888981 1 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.14495852367213397 [4] [3,3] 4 hSpCas9 positive selection 4163514
226888136 226888159 1 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) CTCTTCACCTATATCTACCTTGG PSEN2 ENSG00000143801 -0.0697257534535072 [4] [2,2] -2 hSpCas9 positive selection 4163515
226888990 226889013 1 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) TCATCAAGTACCTCCCAGAGTGG PSEN2 ENSG00000143801 0.08067064324211691 [4] [3,2] 2 hSpCas9 positive selection 4163516
226888083 226888106 1 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) TTGTCTAGTTCATCCATGGCTGG PSEN2 ENSG00000143801 0.17503574650242956 [4] [2,3] 4 hSpCas9 positive selection 4163517
226888096 226888119 1 - 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiGuide) AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.5398610544275186 [4] [0,0,4,3] 4 hSpCas9 positive selection 4227534
226889004 226889027 1 - 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiGuide) ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.9265895773876794 [4] [3,4,2,3] 6 hSpCas9 positive selection 4227535
226888958 226888981 1 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiGuide) CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 1.0667266360711734 [4] [5,5,3,3] 7 hSpCas9 positive selection 4227536
226888136 226888159 1 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiGuide) CTCTTCACCTATATCTACCTTGG PSEN2 ENSG00000143801 0.5912280971943201 [5] [3,1,4,3] 4 hSpCas9 positive selection 4227537
226888990 226889013 1 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiGuide) TCATCAAGTACCTCCCAGAGTGG PSEN2 ENSG00000143801 1.1682219852976474 [3] [0,1,4,4] 8 hSpCas9 positive selection 4227538
226888083 226888106 1 + 26780180 A375 resistance to vemurafenib (GeCKOv1 lentiGuide) TTGTCTAGTTCATCCATGGCTGG PSEN2 ENSG00000143801 0.7066364859886949 [4] [0,3,2,4] 4 hSpCas9 positive selection 4227539
226883803 226883826 1 - 26780180 A375 resistance to vemurafenib (GeCKOv2 lentiGuide) CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.6991590197710595 [2] [3,3] 9 hSpCas9 positive selection 4292660
226883843 226883866 1 - 26780180 A375 resistance to vemurafenib (GeCKOv2 lentiGuide) ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.5913108239493763 [3] [2,0] -8 hSpCas9 positive selection 4292661
226888958 226888981 1 + 26780180 A375 resistance to vemurafenib (GeCKOv2 lentiGuide) CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.18305743309728087 [3] [3,1] 3 hSpCas9 positive selection 4292662
226889004 226889027 1 - 26780180 A375 resistance to vemurafenib (GeCKOv2 lentiGuide) ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.6165244142733178 [2] [1,0] -8 hSpCas9 positive selection 4356919
226894023 226894046 1 - 26780180 A375 resistance to vemurafenib (GeCKOv2 lentiGuide) TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.13682543808017616 [2] [2,1] -3 hSpCas9 positive selection 4356920
226894000 226894023 1 + 26780180 A375 resistance to vemurafenib (GeCKOv2 lentiGuide) CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.18569934171359015 [2] [2,1] 4 hSpCas9 positive selection 4356921
226883746 226883768 1 - 27760321 OCIAML3 viability AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.8062122344906797 [371,286] [320,611] 8 hSpCas9 negative selection 4431276
226883846 226883868 1 + 27760321 OCIAML3 viability GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 0.5514113412877284 [843,703] [869,900] 6 hSpCas9 negative selection 4431277
226888080 226888102 1 + 27760321 OCIAML3 viability CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 0.1447916905063303 [343,337] [180,444] 1 hSpCas9 negative selection 4431278
226888908 226888930 1 + 27760321 OCIAML3 viability ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 0.460557965964273 [493,429] [449,555] 5 hSpCas9 negative selection 4431279
226889010 226889032 1 + 27760321 OCIAML3 viability TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 0.5034904804365464 [654,643] [678,777] 6 hSpCas9 negative selection 4431280
226883746 226883768 1 - 27760321 OCIAML2 viability AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.06465422743176297 [371,286] [252,307] 0 hSpCas9 negative selection 4514739
226883846 226883868 1 + 27760321 OCIAML2 viability GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 -0.33302916848163 [843,703] [409,606] -4 hSpCas9 negative selection 4514740
226888080 226888102 1 + 27760321 OCIAML2 viability CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 -0.1533149622199113 [343,337] [211,296] -2 hSpCas9 negative selection 4514741
226888908 226888930 1 + 27760321 OCIAML2 viability ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 0.26818625122313966 [493,429] [467,423] 3 hSpCas9 negative selection 4514742
226889010 226889032 1 + 27760321 OCIAML2 viability TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 0.36085390815156326 [654,643] [584,796] 5 hSpCas9 negative selection 4514743
226883746 226883768 1 - 27760321 MV411 viability AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 1.2281105949026303 [371,286] [563,417] 8 hSpCas9 negative selection 4598202
226883846 226883868 1 + 27760321 MV411 viability GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 0.7706638734538518 [843,703] [364,1622] 5 hSpCas9 negative selection 4598203
226888080 226888102 1 + 27760321 MV411 viability CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 0.42113644805621797 [343,337] [395,160] 3 hSpCas9 negative selection 4598204
226888908 226888930 1 + 27760321 MV411 viability ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 0.8446025814393971 [493,429] [749,239] 6 hSpCas9 negative selection 4598205
226889010 226889032 1 + 27760321 MV411 viability TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 0.6077630829164723 [654,643] [703,580] 4 hSpCas9 negative selection 4598206
226883746 226883768 1 - 27760321 HL60 viability AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.23417700903408878 [371,286] [273,356] 3 hSpCas9 negative selection 4681665
226883846 226883868 1 + 27760321 HL60 viability GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 -0.07646553033128123 [843,703] [634,556] -1 hSpCas9 negative selection 4681666
226888080 226888102 1 + 27760321 HL60 viability CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 -0.027126222960600854 [343,337] [209,341] 0 hSpCas9 negative selection 4681667
226888908 226888930 1 + 27760321 HL60 viability ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 -0.7757980100160355 [493,429] [232,205] -7 hSpCas9 negative selection 4681668
226889010 226889032 1 + 27760321 HL60 viability TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 0.4177405340487974 [654,643] [679,742] 5 hSpCas9 negative selection 4681669
226883746 226883768 1 - 27760321 HT1080 viability AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 -0.03549659275631373 [286,223] [10,195] 0 hSpCas9 negative selection 4765128
226883846 226883868 1 + 27760321 HT1080 viability GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 0.9594420341075403 [703,549] [553,410] 5 hSpCas9 negative selection 4765129
226888080 226888102 1 + 27760321 HT1080 viability CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 0.6053991267139346 [337,263] [275,79] 3 hSpCas9 negative selection 4765130
226888908 226888930 1 + 27760321 HT1080 viability ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 0.19869733900230183 [429,335] [145,206] 1 hSpCas9 negative selection 4765131
226889010 226889032 1 + 27760321 HT1080 viability TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 0.689995523352499 [643,502] [64,700] 3 hSpCas9 negative selection 4765132
226883746 226883768 1 - 27760321 HT29 viability after 7 days AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.30371517724892094 [286,223] [630,338,281] 4 hSpCas9 negative selection 4848591
226883846 226883868 1 + 27760321 HT29 viability after 7 days GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 -0.4290546044224025 [703,549] [555,652,580] -6 hSpCas9 negative selection 4848592
226888080 226888102 1 + 27760321 HT29 viability after 7 days CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 0.12788112506848504 [337,263] [349,272,627] 2 hSpCas9 negative selection 4848593
226888908 226888930 1 + 27760321 HT29 viability after 7 days ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 -0.15384294112446747 [429,335] [586,543,223] -2 hSpCas9 negative selection 4848594
226889010 226889032 1 + 27760321 HT29 viability after 7 days TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 -0.17875959699412314 [643,502] [565,588,781] -3 hSpCas9 negative selection 4848595
226883746 226883768 1 - 27760321 HT29 viability after 25 days AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.5808831394567914 [286,223] [425,423,462] 6 hSpCas9 negative selection 4932054
226883846 226883868 1 + 27760321 HT29 viability after 25 days GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 0.025615703821914804 [703,549] [786,559,848] 0 hSpCas9 negative selection 4932055
226888080 226888102 1 + 27760321 HT29 viability after 25 days CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 -0.2196942688900893 [337,263] [204,334,357] -2 hSpCas9 negative selection 4932056
226888908 226888930 1 + 27760321 HT29 viability after 25 days ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 0.5452861858279902 [429,335] [588,703,623] 6 hSpCas9 negative selection 4932057
226889010 226889032 1 + 27760321 HT29 viability after 25 days TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 0.4112114272723979 [643,502] [811,616,1224] 4 hSpCas9 negative selection 4932058
226883746 226883768 1 - 27760321 HT29 viability after 22 days AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.8529742285826265 [286,223] [339,598,667] 8 hSpCas9 negative selection 5015517
226883846 226883868 1 + 27760321 HT29 viability after 22 days GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 0.08011530458346039 [703,549] [797,728,770] 0 hSpCas9 negative selection 5015518
226888080 226888102 1 + 27760321 HT29 viability after 22 days CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 -0.43523706508266874 [337,263] [336,271,159] -4 hSpCas9 negative selection 5015519
226888908 226888930 1 + 27760321 HT29 viability after 22 days ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 0.5742686753173153 [429,335] [736,553,684] 6 hSpCas9 negative selection 5015520
226889010 226889032 1 + 27760321 HT29 viability after 22 days TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 0.1792188462304345 [643,502] [854,572,821] 1 hSpCas9 negative selection 5015521
226883746 226883768 1 - 27760321 HT29 viability after 19 days AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.42604212132300545 [286,223] [619,313,271] 4 hSpCas9 negative selection 5098980
226883846 226883868 1 + 27760321 HT29 viability after 19 days GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 0.24955659523123996 [703,549] [951,588,1019] 2 hSpCas9 negative selection 5098981
226888080 226888102 1 + 27760321 HT29 viability after 19 days CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 -0.4450234392935069 [337,263] [354,236,179] -4 hSpCas9 negative selection 5098982
226888908 226888930 1 + 27760321 HT29 viability after 19 days ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 0.03784962332379299 [429,335] [636,350,382] 0 hSpCas9 negative selection 5098983
226889010 226889032 1 + 27760321 HT29 viability after 19 days TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 0.31009491141120415 [643,502] [809,982,651] 3 hSpCas9 negative selection 5098984
226883746 226883768 1 - 27760321 HT29 viability after 16 days AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.9007455313708977 [286,223] [540,598,459] 9 hSpCas9 negative selection 5182443
226883846 226883868 1 + 27760321 HT29 viability after 16 days GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 0.0199306818904339 [703,549] [949,416,796] 0 hSpCas9 negative selection 5182444
226888080 226888102 1 + 27760321 HT29 viability after 16 days CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 0.5157029254592952 [337,263] [601,280,577] 6 hSpCas9 negative selection 5182445
226888908 226888930 1 + 27760321 HT29 viability after 16 days ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 0.31837477897394206 [429,335] [496,550,550] 3 hSpCas9 negative selection 5182446
226889010 226889032 1 + 27760321 HT29 viability after 16 days TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 0.22949803602805008 [643,502] [827,596,842] 2 hSpCas9 negative selection 5182447
226883746 226883768 1 - 27760321 HT29 viability after 13 days AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.7090327910213418 [286,223] [458,482,509] 8 hSpCas9 negative selection 5265906
226883846 226883868 1 + 27760321 HT29 viability after 13 days GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 -0.0944580322556885 [703,549] [653,760,631] -1 hSpCas9 negative selection 5265907
226888080 226888102 1 + 27760321 HT29 viability after 13 days CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 0.26304534791578754 [337,263] [372,495,389] 3 hSpCas9 negative selection 5265908
226888908 226888930 1 + 27760321 HT29 viability after 13 days ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 0.5385194639855171 [429,335] [829,635,479] 7 hSpCas9 negative selection 5265909
226889010 226889032 1 + 27760321 HT29 viability after 13 days TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 0.37062067070834526 [643,502] [955,979,656] 5 hSpCas9 negative selection 5265910
226883746 226883768 1 - 27760321 HT29 viability after 10 days AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 1.0077630644242177 [286,223] [862,476,580] 9 hSpCas9 negative selection 5349369
226883846 226883868 1 + 27760321 HT29 viability after 10 days GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 -0.0421081663224282 [703,549] [645,951,689] 0 hSpCas9 negative selection 5349370
226888080 226888102 1 + 27760321 HT29 viability after 10 days CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 0.24710650518106234 [337,263] [426,372,533] 3 hSpCas9 negative selection 5349371
226888908 226888930 1 + 27760321 HT29 viability after 10 days ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 0.31428853226279396 [429,335] [618,707,462] 4 hSpCas9 negative selection 5349372
226889010 226889032 1 + 27760321 HT29 viability after 10 days TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 -0.09082625963151902 [643,502] [596,684,733] -1 hSpCas9 negative selection 5349373
226883746 226883768 1 - 27760321 MOLM13 viability AACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.9546889426922331 [371,286] [166,519] 6 hSpCas9 negative selection 5432832
226883846 226883868 1 + 27760321 MOLM13 viability GTCACTCTGTGCATGATCGTGG PSEN2 ENSG00000143801 0.2948478933756411 [843,703] [499,561] 2 hSpCas9 negative selection 5432833
226888080 226888102 1 + 27760321 MOLM13 viability CTGTTGTCTAGTTCATCCATGG PSEN2 ENSG00000143801 0.4669078997090996 [343,337] [493,72] 3 hSpCas9 negative selection 5432834
226888908 226888930 1 + 27760321 MOLM13 viability ATGGTGTGCATCCACTGGAAGG PSEN2 ENSG00000143801 1.1758067154930296 [493,429] [782,420] 8 hSpCas9 negative selection 5432835
226889010 226889032 1 + 27760321 MOLM13 viability TGGTCCGCGTGGGTCATCCTGG PSEN2 ENSG00000143801 1.1614898139553684 [654,643] [904,750] 7 hSpCas9 negative selection 5432836
226870616 226870639 1 + 27661255 K562 viability GCGTAAACTCCGCTGGAGCGCGG PSEN2 ENSG00000143801 0.17997148691444353 [205,276] [218,215] 6 dCas9-KRAB negative selection 5504767
226870990 226871013 1 + 27661255 K562 viability GCGCGGCGCGAGCGGTTAAAGGG PSEN2 ENSG00000143801 0.29009744646392766 [262,196] [241,211] 8 dCas9-KRAB negative selection 5504768
226870994 226871017 1 + 27661255 K562 viability GGCGCGAGCGGTTAAAGGGCCGG PSEN2 ENSG00000143801 -0.00425162753106223 [339,363] [306,256] 0 dCas9-KRAB negative selection 5504769
226871011 226871034 1 + 27661255 K562 viability GGCCGGTGCATTTAAAGGAGCGG PSEN2 ENSG00000143801 -0.08986217924051565 [449,298] [321,249] -3 dCas9-KRAB negative selection 5504770
226883803 226883826 1 - 27260156 BXPC3 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.3407275612690626 [309] [385,400,410,448] 7 hSpCas9 negative selection 5565120
226883843 226883866 1 - 27260156 BXPC3 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.04371589955558685 [496] [471,484,487,581] -1 hSpCas9 negative selection 5565121
226888958 226888981 1 + 27260156 BXPC3 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.16647696765348302 [559] [605,589,730,714] 3 hSpCas9 negative selection 5565122
226889004 226889027 1 - 27260156 BXPC3 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.17413721264617854 [296] [426,308,282,375] 4 hSpCas9 negative selection 5629379
226894023 226894046 1 - 27260156 BXPC3 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 0.04572284967591683 [354] [379,372,352,429] 1 hSpCas9 negative selection 5629380
226894000 226894023 1 + 27260156 BXPC3 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.01505322558146216 [227] [238,203,240,262] 0 hSpCas9 negative selection 5629381
226883803 226883826 1 - 27260156 A673 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.6600670979916671 [309] [645,573,490,651] 9 hSpCas9 negative selection 5686371
226883843 226883866 1 - 27260156 A673 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.11039844475079887 [496] [593,417,498,716] -3 hSpCas9 negative selection 5686372
226888958 226888981 1 + 27260156 A673 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.24783704704173237 [559] [808,698,846,842] 6 hSpCas9 negative selection 5686373
226889004 226889027 1 - 27260156 A673 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.20007249283256479 [296] [367,286,306,284] -5 hSpCas9 negative selection 5750630
226894023 226894046 1 - 27260156 A673 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.29792127781035843 [354] [368,337,307,375] -6 hSpCas9 negative selection 5750631
226894000 226894023 1 + 27260156 A673 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.22918774180119394 [227] [311,321,353,291] 5 hSpCas9 negative selection 5750632
226883803 226883826 1 - 27260156 A375 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.8743899809279039 [309] [662,739,650,614] 9 hSpCas9 negative selection 5807622
226883843 226883866 1 - 27260156 A375 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.19759759572873875 [496] [595,448,542,435] -3 hSpCas9 negative selection 5807623
226888958 226888981 1 + 27260156 A375 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 -0.09154359041621751 [559] [576,671,663,554] -1 hSpCas9 negative selection 5807624
226889004 226889027 1 - 27260156 A375 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.3976383172194511 [296] [149,250,276,359] -5 hSpCas9 negative selection 5871881
226894023 226894046 1 - 27260156 A375 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.29864917726679113 [354] [388,379,427,175] -4 hSpCas9 negative selection 5871882
226894000 226894023 1 + 27260156 A375 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.15969069343667797 [227] [106,295,320,235] -2 hSpCas9 negative selection 5871883
226883803 226883826 1 - 27260156 COLO741 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.671587223296945 [309] [857,475,579] 9 hSpCas9 negative selection 5928873
226883843 226883866 1 - 27260156 COLO741 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.18456695945849305 [496] [592,527,556] -4 hSpCas9 negative selection 5928874
226888958 226888981 1 + 27260156 COLO741 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.20687344978314876 [559] [908,795,780] 4 hSpCas9 negative selection 5928875
226889004 226889027 1 - 27260156 COLO741 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.03356658071733509 [296] [476,380,269] 0 hSpCas9 negative selection 5993132
226894023 226894046 1 - 27260156 COLO741 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.04886952091114699 [354] [435,505,376] -1 hSpCas9 negative selection 5993133
226894000 226894023 1 + 27260156 COLO741 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.04905968600612376 [227] [361,223,320] 1 hSpCas9 negative selection 5993134
226883803 226883826 1 - 27260156 CAL120 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.8384251102322055 [309] [1038,415,666] 9 hSpCas9 negative selection 6050124
226883843 226883866 1 - 27260156 CAL120 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 0.3595103035566245 [496] [761,910,703] 5 hSpCas9 negative selection 6050125
226888958 226888981 1 + 27260156 CAL120 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.09702659813157938 [559] [887,558,808] 1 hSpCas9 negative selection 6050126
226889004 226889027 1 - 27260156 CAL120 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.17675194107494419 [296] [379,426,439] 2 hSpCas9 negative selection 6114383
226894023 226894046 1 - 27260156 CAL120 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.28526954315759306 [354] [366,300,418] -4 hSpCas9 negative selection 6114384
226894000 226894023 1 + 27260156 CAL120 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.13814978126356192 [227] [335,241,207] -2 hSpCas9 negative selection 6114385
226883803 226883826 1 - 27260156 CADOES1 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.7850242116811117 [309] [452,539,533,458] 9 hSpCas9 negative selection 6171375
226883843 226883866 1 - 27260156 CADOES1 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.14547201441606677 [496] [419,523,407,315] -3 hSpCas9 negative selection 6171376
226888958 226888981 1 + 27260156 CADOES1 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.033509208710438554 [559] [578,470,447,637] 0 hSpCas9 negative selection 6171377
226889004 226889027 1 - 27260156 CADOES1 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.18969925485643357 [296] [200,253,268,244] -3 hSpCas9 negative selection 6235634
226894023 226894046 1 - 27260156 CADOES1 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.3237892324168243 [354] [193,315,318,224] -5 hSpCas9 negative selection 6235635
226894000 226894023 1 + 27260156 CADOES1 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.4399200267853558 [227] [205,121,142,153] -6 hSpCas9 negative selection 6235636
226883803 226883826 1 - 27260156 EWS502 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.49383190028821217 [309] [325,585,428,521] 8 hSpCas9 negative selection 6292626
226883843 226883866 1 - 27260156 EWS502 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.0537234481434645 [496] [448,441,531,621] -1 hSpCas9 negative selection 6292627
226888958 226888981 1 + 27260156 EWS502 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.1630446391790658 [559] [580,586,796,706] 3 hSpCas9 negative selection 6292628
226889004 226889027 1 - 27260156 EWS502 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.031222816009354726 [296] [280,309,265,380] 0 hSpCas9 negative selection 6356885
226894023 226894046 1 - 27260156 EWS502 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.2099446665602031 [354] [380,292,344,270] -4 hSpCas9 negative selection 6356886
226894000 226894023 1 + 27260156 EWS502 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.19743056551880445 [227] [347,127,145,204] -4 hSpCas9 negative selection 6356887
226883803 226883826 1 - 27260156 EW8 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.5088048047008769 [309] [296,369,441,298] 8 hSpCas9 negative selection 6413877
226883843 226883866 1 - 27260156 EW8 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.007655305786207628 [496] [387,453,258,522] 0 hSpCas9 negative selection 6413878
226888958 226888981 1 + 27260156 EW8 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.22720133756277872 [559] [659,619,360,525] 4 hSpCas9 negative selection 6413879
226889004 226889027 1 - 27260156 EW8 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.22396413357964684 [296] [215,287,172,153] -4 hSpCas9 negative selection 6478136
226894023 226894046 1 - 27260156 EW8 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.09720031882732644 [354] [532,204,186,192] -2 hSpCas9 negative selection 6478137
226894000 226894023 1 + 27260156 EW8 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.07078094936396795 [227] [152,227,181,136] -1 hSpCas9 negative selection 6478138
226883803 226883826 1 - 27260156 CORL105 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.7531217028500763 [309] [649,691,619,485] 9 hSpCas9 negative selection 6535128
226883843 226883866 1 - 27260156 CORL105 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.28342696279997714 [496] [437,431,557,495] -5 hSpCas9 negative selection 6535129
226888958 226888981 1 + 27260156 CORL105 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 -0.09166613484266445 [559] [649,553,677,590] -2 hSpCas9 negative selection 6535130
226889004 226889027 1 - 27260156 CORL105 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.042547934047542646 [296] [335,388,328,293] -1 hSpCas9 negative selection 6599387
226894023 226894046 1 - 27260156 CORL105 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.10103837862669324 [354] [372,306,271,579] -2 hSpCas9 negative selection 6599388
226894000 226894023 1 + 27260156 CORL105 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.3689811219645486 [227] [420,385,300,265] 7 hSpCas9 negative selection 6599389
226883803 226883826 1 - 27260156 HS294T viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 1.1779877067347133 [309] [212,276,169,460] 9 hSpCas9 negative selection 6656379
226883843 226883866 1 - 27260156 HS294T viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.4956907542352327 [496] [140,131,101,175] -6 hSpCas9 negative selection 6656380
226888958 226888981 1 + 27260156 HS294T viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.5253813842867369 [559] [241,206,284,563] 7 hSpCas9 negative selection 6656381
226889004 226889027 1 - 27260156 HS294T viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.6662078790329186 [296] [380,86,92,144] 8 hSpCas9 negative selection 6720638
226894023 226894046 1 - 27260156 HS294T viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.6236038639649222 [354] [80,59,96,125] -7 hSpCas9 negative selection 6720639
226894000 226894023 1 + 27260156 HS294T viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.16783584080660385 [227] [92,67,65,86] -2 hSpCas9 negative selection 6720640
226883803 226883826 1 - 27260156 HCC44 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.5610469766132338 [309] [438,441,775,457] 8 hSpCas9 negative selection 6777630
226883843 226883866 1 - 27260156 HCC44 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 0.14904901650904556 [496] [558,743,539,607] 2 hSpCas9 negative selection 6777631
226888958 226888981 1 + 27260156 HCC44 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.3715570017169616 [559] [724,702,924,939] 6 hSpCas9 negative selection 6777632
226889004 226889027 1 - 27260156 HCC44 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.052253484013123463 [296] [388,437,288,257] 0 hSpCas9 negative selection 6841889
226894023 226894046 1 - 27260156 HCC44 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.2228233740561692 [354] [452,414,137,331] -4 hSpCas9 negative selection 6841890
226894000 226894023 1 + 27260156 HCC44 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.19532414548409394 [227] [296,229,456,233] 3 hSpCas9 negative selection 6841891
226883803 226883826 1 - 27260156 G402 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.6626096981806228 [309] [941,525,411,559] 7 hSpCas9 negative selection 6898881
226883843 226883866 1 - 27260156 G402 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.2183408557356678 [496] [699,635,225,551] -3 hSpCas9 negative selection 6898882
226888958 226888981 1 + 27260156 G402 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.09118873604004124 [559] [871,880,701,494] 1 hSpCas9 negative selection 6898883
226889004 226889027 1 - 27260156 G402 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.4435405021278742 [296] [267,319,208,270] -5 hSpCas9 negative selection 6963140
226894023 226894046 1 - 27260156 G402 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 0.42715598671066496 [354] [180,341,481,1218] 5 hSpCas9 negative selection 6963141
226894000 226894023 1 + 27260156 G402 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.06369181800960766 [227] [338,311,140,373] 0 hSpCas9 negative selection 6963142
226883803 226883826 1 - 27260156 L33 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.7306782176723854 [309] [597,174,337,492] 9 hSpCas9 negative selection 7020132
226883843 226883866 1 - 27260156 L33 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.1275459429261538 [496] [454,217,247,437] -3 hSpCas9 negative selection 7020133
226888958 226888981 1 + 27260156 L33 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.20264624330060793 [559] [599,252,438,662] 4 hSpCas9 negative selection 7020134
226889004 226889027 1 - 27260156 L33 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.18980218102092672 [296] [184,100,172,335] -4 hSpCas9 negative selection 7084391
226894023 226894046 1 - 27260156 L33 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.0013030883309916863 [354] [397,155,211,301] 0 hSpCas9 negative selection 7084392
226894000 226894023 1 + 27260156 L33 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.06542110716204164 [227] [187,83,171,205] -1 hSpCas9 negative selection 7084393
226883803 226883826 1 - 27260156 K562 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.6301292515377855 [309] [671,468,319,279] 7 hSpCas9 negative selection 7141383
226883843 226883866 1 - 27260156 K562 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.08564020290951106 [496] [616,180,536,338] -1 hSpCas9 negative selection 7141384
226888958 226888981 1 + 27260156 K562 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.39042960323254283 [559] [357,659,1227,366] 5 hSpCas9 negative selection 7141385
226889004 226889027 1 - 27260156 K562 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.13202899510417676 [296] [223,662,233,72] 1 hSpCas9 negative selection 7205642
226894023 226894046 1 - 27260156 K562 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.2666427206093596 [354] [151,312,387,194] -3 hSpCas9 negative selection 7205643
226894000 226894023 1 + 27260156 K562 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.717422493956996 [227] [396,571,260,139] 8 hSpCas9 negative selection 7205644
226883803 226883826 1 - 27260156 HT29 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.735285825573919 [309] [658,635,648,570] 9 hSpCas9 negative selection 7262634
226883843 226883866 1 - 27260156 HT29 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.3627699444206603 [496] [591,415,333,530] -6 hSpCas9 negative selection 7262635
226888958 226888981 1 + 27260156 HT29 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.05077113270914296 [559] [787,792,791,483] 1 hSpCas9 negative selection 7262636
226889004 226889027 1 - 27260156 HT29 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.25995276583189075 [296] [600,475,270,398] 5 hSpCas9 negative selection 7326893
226894023 226894046 1 - 27260156 HT29 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.3135754090732043 [354] [320,297,510,260] -6 hSpCas9 negative selection 7326894
226894000 226894023 1 + 27260156 HT29 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.05298969597202141 [227] [271,374,189,313] 1 hSpCas9 negative selection 7326895
226883803 226883826 1 - 27260156 MHHES1 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.7273173997148081 [309] [742,465,702,430] 9 hSpCas9 negative selection 7383885
226883843 226883866 1 - 27260156 MHHES1 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 0.027312493039207297 [496] [753,486,689,393] 0 hSpCas9 negative selection 7383886
226888958 226888981 1 + 27260156 MHHES1 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 -0.27914351829526457 [559] [565,459,457,569] -5 hSpCas9 negative selection 7383887
226889004 226889027 1 - 27260156 MHHES1 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.11909739110286666 [296] [378,352,342,368] 2 hSpCas9 negative selection 7448144
226894023 226894046 1 - 27260156 MHHES1 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.05429722304181317 [354] [391,359,505,293] -1 hSpCas9 negative selection 7448145
226894000 226894023 1 + 27260156 MHHES1 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.09112347431977119 [227] [208,311,309,256] 1 hSpCas9 negative selection 7448146
226883803 226883826 1 - 27260156 MEWO viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.5731039897444176 [309] [543,252,519] 9 hSpCas9 negative selection 7505136
226883843 226883866 1 - 27260156 MEWO viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.6371119036619949 [496] [420,197,301] -8 hSpCas9 negative selection 7505137
226888958 226888981 1 + 27260156 MEWO viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.32004207221438064 [559] [790,551,645] 6 hSpCas9 negative selection 7505138
226889004 226889027 1 - 27260156 MEWO viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.05492969085647914 [296] [233,346,273] 1 hSpCas9 negative selection 7569395
226894023 226894046 1 - 27260156 MEWO viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.39430485192228476 [354] [368,164,246] -7 hSpCas9 negative selection 7569396
226894000 226894023 1 + 27260156 MEWO viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.3670303819435623 [227] [385,219,240] 7 hSpCas9 negative selection 7569397
226883803 226883826 1 - 27260156 LNCAPCLONEFGC viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.6822787477605374 [309] [432,427,544,411] 9 hSpCas9 negative selection 7626387
226883843 226883866 1 - 27260156 LNCAPCLONEFGC viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.2360066513876597 [496] [431,287,502,328] -4 hSpCas9 negative selection 7626388
226888958 226888981 1 + 27260156 LNCAPCLONEFGC viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.020451305188509017 [559] [591,281,624,588] 0 hSpCas9 negative selection 7626389
226889004 226889027 1 - 27260156 LNCAPCLONEFGC viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.02444782409219659 [296] [205,200,357,347] 0 hSpCas9 negative selection 7690646
226894023 226894046 1 - 27260156 LNCAPCLONEFGC viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.366400279304183 [354] [175,242,299,287] -5 hSpCas9 negative selection 7690647
226894000 226894023 1 + 27260156 LNCAPCLONEFGC viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.0006757407502593349 [227] [237,241,169,167] 0 hSpCas9 negative selection 7690648
226883803 226883826 1 - 27260156 PANC0327 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.9647553019625156 [309] [622,356,578,620] 9 hSpCas9 negative selection 7747638
226883843 226883866 1 - 27260156 PANC0327 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 0.08352075594409415 [496] [722,202,410,588] 1 hSpCas9 negative selection 7747639
226888958 226888981 1 + 27260156 PANC0327 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 -0.09210223008834789 [559] [361,316,816,381] -1 hSpCas9 negative selection 7747640
226889004 226889027 1 - 27260156 PANC0327 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.13850432709847715 [296] [377,107,255,244] -2 hSpCas9 negative selection 7811897
226894023 226894046 1 - 27260156 PANC0327 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.008383516314997175 [354] [436,229,349,257] 0 hSpCas9 negative selection 7811898
226894000 226894023 1 + 27260156 PANC0327 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.17197773819491302 [227] [347,154,128,103] -3 hSpCas9 negative selection 7811899
226883803 226883826 1 - 27260156 NCIH2009 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.6618158887290916 [309] [829,526,728] 8 hSpCas9 negative selection 7868889
226883843 226883866 1 - 27260156 NCIH2009 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.23305060906704977 [496] [566,519,680] -3 hSpCas9 negative selection 7868890
226888958 226888981 1 + 27260156 NCIH2009 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.305435145129768 [559] [1377,872,730] 4 hSpCas9 negative selection 7868891
226889004 226889027 1 - 27260156 NCIH2009 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.20118432472638736 [296] [588,266,272] -3 hSpCas9 negative selection 7933148
226894023 226894046 1 - 27260156 NCIH2009 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 0.44562945527423437 [354] [925,556,593] 6 hSpCas9 negative selection 7933149
226894000 226894023 1 + 27260156 NCIH2009 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.09630084312929665 [227] [464,320,259] 1 hSpCas9 negative selection 7933150
226883803 226883826 1 - 27260156 NCIH1373 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 1.0392622490309746 [309] [764,593,779,192] 9 hSpCas9 negative selection 7990140
226883843 226883866 1 - 27260156 NCIH1373 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.05976395750175789 [496] [574,425,634,134] 0 hSpCas9 negative selection 7990141
226888958 226888981 1 + 27260156 NCIH1373 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.9463066938524675 [559] [1163,1366,1229,271] 8 hSpCas9 negative selection 7990142
226889004 226889027 1 - 27260156 NCIH1373 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.33219088760984244 [296] [367,431,539,82] 3 hSpCas9 negative selection 8054399
226894023 226894046 1 - 27260156 NCIH1373 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.16456478255781054 [354] [481,113,321,146] -2 hSpCas9 negative selection 8054400
226894000 226894023 1 + 27260156 NCIH1373 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.009039268745617335 [227] [390,165,247,62] 0 hSpCas9 negative selection 8054401
226883803 226883826 1 - 27260156 PATU8902 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 1.608806505523921 [309] [1266,1730,404,2197] 9 hSpCas9 negative selection 8111391
226883843 226883866 1 - 27260156 PATU8902 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 0.46719802887295114 [496] [1264,1081,533,1056] 5 hSpCas9 negative selection 8111392
226888958 226888981 1 + 27260156 PATU8902 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 -0.32371459261395774 [559] [687,633,640,504] -3 hSpCas9 negative selection 8111393
226889004 226889027 1 - 27260156 PATU8902 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.7075903829189978 [296] [281,405,130,219] -6 hSpCas9 negative selection 8175650
226894023 226894046 1 - 27260156 PATU8902 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 0.6948149605515134 [354] [765,755,683,1048] 7 hSpCas9 negative selection 8175651
226894000 226894023 1 + 27260156 PATU8902 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.4763696891507696 [227] [138,558,592,436] 5 hSpCas9 negative selection 8175652
226883803 226883826 1 - 27260156 PANC1 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.9518297824287594 [309] [570,807,425,334] 9 hSpCas9 negative selection 8232642
226883843 226883866 1 - 27260156 PANC1 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.20594461902316347 [496] [289,394,495,310] -3 hSpCas9 negative selection 8232643
226888958 226888981 1 + 27260156 PANC1 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.23316775444032833 [559] [710,642,595,350] 4 hSpCas9 negative selection 8232644
226889004 226889027 1 - 27260156 PANC1 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.4291225924263481 [296] [256,452,421,272] 7 hSpCas9 negative selection 8296901
226894023 226894046 1 - 27260156 PANC1 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.095333301791868 [354] [268,255,251,343] -1 hSpCas9 negative selection 8296902
226894000 226894023 1 + 27260156 PANC1 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.0035989683594377375 [227] [247,214,132,185] 0 hSpCas9 negative selection 8296903
226883803 226883826 1 - 27260156 PANC0813 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.8836030257747394 [309] [786,539,765,607] 9 hSpCas9 negative selection 8353893
226883843 226883866 1 - 27260156 PANC0813 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 0.23565506062775865 [496] [782,775,572,627] 4 hSpCas9 negative selection 8353894
226888958 226888981 1 + 27260156 PANC0813 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.36487849387877036 [559] [1020,761,879,745] 6 hSpCas9 negative selection 8353895
226889004 226889027 1 - 27260156 PANC0813 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.03783680507807763 [296] [354,374,401,302] 0 hSpCas9 negative selection 8418152
226894023 226894046 1 - 27260156 PANC0813 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 0.16767101457231778 [354] [395,672,528,278] 2 hSpCas9 negative selection 8418153
226894000 226894023 1 + 27260156 PANC0813 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.20034416318906456 [227] [233,249,283,167] -3 hSpCas9 negative selection 8418154
226883803 226883826 1 - 27260156 RDES viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.6039883808350068 [309] [519,537,521,578] 8 hSpCas9 negative selection 8475144
226883843 226883866 1 - 27260156 RDES viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.1500773927590916 [496] [435,445,570,635] -3 hSpCas9 negative selection 8475145
226888958 226888981 1 + 27260156 RDES viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 -0.3104311526528827 [559] [516,409,636,509] -5 hSpCas9 negative selection 8475146
226889004 226889027 1 - 27260156 RDES viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.04921837113795313 [296] [282,275,463,416] 0 hSpCas9 negative selection 8539403
226894023 226894046 1 - 27260156 RDES viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.423358644134508 [354] [251,333,270,367] -6 hSpCas9 negative selection 8539404
226894000 226894023 1 + 27260156 RDES viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.05881546714775965 [227] [196,298,269,238] -1 hSpCas9 negative selection 8539405
226883803 226883826 1 - 27260156 PC3 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.6243804898813843 [309] [278,601,786,388] 9 hSpCas9 negative selection 8596395
226883843 226883866 1 - 27260156 PC3 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 0.040353243766910296 [496] [249,602,722,616] 0 hSpCas9 negative selection 8596396
226888958 226888981 1 + 27260156 PC3 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 -0.08665198433333948 [559] [283,683,754,518] -2 hSpCas9 negative selection 8596397
226889004 226889027 1 - 27260156 PC3 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.19247043809582887 [296] [198,183,327,356] -4 hSpCas9 negative selection 8660654
226894023 226894046 1 - 27260156 PC3 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.8747286336750726 [354] [114,108,333,294] -9 hSpCas9 negative selection 8660655
226894000 226894023 1 + 27260156 PC3 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.3280457700891932 [227] [177,382,376,249] 7 hSpCas9 negative selection 8660656
226883803 226883826 1 - 27260156 PATU8988T viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.5398235368916563 [309] [426,287,654,347] 8 hSpCas9 negative selection 8717646
226883843 226883866 1 - 27260156 PATU8988T viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.20979258171630882 [496] [374,418,468,395] -4 hSpCas9 negative selection 8717647
226888958 226888981 1 + 27260156 PATU8988T viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 -0.11393810771502222 [559] [482,704,377,450] -2 hSpCas9 negative selection 8717648
226889004 226889027 1 - 27260156 PATU8988T viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.01809813814729766 [296] [151,175,493,329] 0 hSpCas9 negative selection 8781905
226894023 226894046 1 - 27260156 PATU8988T viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.19362435334638034 [354] [242,451,181,341] -3 hSpCas9 negative selection 8781906
226894000 226894023 1 + 27260156 PATU8988T viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.43547861304209334 [227] [272,311,298,309] 7 hSpCas9 negative selection 8781907
226883803 226883826 1 - 27260156 T47D viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.5506400971937028 [309] [516,506,544,548] 9 hSpCas9 negative selection 8838897
226883843 226883866 1 - 27260156 T47D viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.18134901372514917 [496] [522,434,554,535] -4 hSpCas9 negative selection 8838898
226888958 226888981 1 + 27260156 T47D viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.05029245366180518 [559] [660,636,696,710] 1 hSpCas9 negative selection 8838899
226889004 226889027 1 - 27260156 T47D viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.08393567481907083 [296] [376,351,266,307] -2 hSpCas9 negative selection 8903156
226894023 226894046 1 - 27260156 T47D viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.40668632946334343 [354] [349,270,306,323] -7 hSpCas9 negative selection 8903157
226894000 226894023 1 + 27260156 T47D viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.02881725365774357 [227] [245,193,351,297] 0 hSpCas9 negative selection 8903158
226883803 226883826 1 - 27260156 SU8686 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.6553166282787352 [309] [410,493,387,674] 9 hSpCas9 negative selection 8960148
226883843 226883866 1 - 27260156 SU8686 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.13627280726506757 [496] [480,402,381,538] -2 hSpCas9 negative selection 8960149
226888958 226888981 1 + 27260156 SU8686 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.2982530349008625 [559] [581,609,840,724] 5 hSpCas9 negative selection 8960150
226889004 226889027 1 - 27260156 SU8686 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.1833102515625838 [296] [247,315,485,294] 3 hSpCas9 negative selection 9024407
226894023 226894046 1 - 27260156 SU8686 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 0.13079877655474942 [354] [321,379,464,380] 2 hSpCas9 negative selection 9024408
226894000 226894023 1 + 27260156 SU8686 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.059613431345914236 [227] [329,177,165,175] -1 hSpCas9 negative selection 9024409
226883803 226883826 1 - 27260156 SKES1 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.49147919526720224 [309] [470,561,385,346] 8 hSpCas9 negative selection 9081399
226883843 226883866 1 - 27260156 SKES1 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.030101937810008216 [496] [583,408,434,510] 0 hSpCas9 negative selection 9081400
226888958 226888981 1 + 27260156 SKES1 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.14380338008244103 [559] [746,613,645,487] 3 hSpCas9 negative selection 9081401
226889004 226889027 1 - 27260156 SKES1 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.2962438199087192 [296] [244,272,204,243] -6 hSpCas9 negative selection 9145658
226894023 226894046 1 - 27260156 SKES1 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.21844011133536306 [354] [357,343,360,177] -5 hSpCas9 negative selection 9145659
226894000 226894023 1 + 27260156 SKES1 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.14450859033315155 [227] [195,275,254,268] 3 hSpCas9 negative selection 9145660
226883803 226883826 1 - 27260156 TOV112D viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.326170542152842 [309] [542,553,274,241] 6 hSpCas9 negative selection 9202650
226883843 226883866 1 - 27260156 TOV112D viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.01857723054582102 [496] [510,570,338,562] 0 hSpCas9 negative selection 9202651
226888958 226888981 1 + 27260156 TOV112D viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.2791453750958567 [559] [671,744,696,623] 5 hSpCas9 negative selection 9202652
226889004 226889027 1 - 27260156 TOV112D viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.13725638824223685 [296] [156,497,243,229] -3 hSpCas9 negative selection 9266909
226894023 226894046 1 - 27260156 TOV112D viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.34775243485097856 [354] [251,413,204,276] -6 hSpCas9 negative selection 9266910
226894000 226894023 1 + 27260156 TOV112D viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 0.592117153522614 [227] [201,436,504,245] 9 hSpCas9 negative selection 9266911
226883803 226883826 1 - 27260156 TC71 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.40182139988064225 [309] [470,411,418,454] 8 hSpCas9 negative selection 9323901
226883843 226883866 1 - 27260156 TC71 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.12433932999670455 [496] [439,428,580,503] -3 hSpCas9 negative selection 9323902
226888958 226888981 1 + 27260156 TC71 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 0.2315477472847507 [559] [588,758,673,806] 6 hSpCas9 negative selection 9323903
226889004 226889027 1 - 27260156 TC71 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 0.09672297681949171 [296] [428,310,327,288] 2 hSpCas9 negative selection 9388160
226894023 226894046 1 - 27260156 TC71 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 0.016472798368184494 [354] [344,530,340,320] 0 hSpCas9 negative selection 9388161
226894000 226894023 1 + 27260156 TC71 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.2054477618451782 [227] [225,191,180,251] -5 hSpCas9 negative selection 9388162
226883803 226883826 1 - 27260156 TC32 viability CGTGCTTCGCTCCGTATTTGAGG PSEN2 ENSG00000143801 0.6322968959765802 [309] [447,378,457,525] 9 hSpCas9 negative selection 9445152
226883843 226883866 1 - 27260156 TC32 viability ACGATCATGCACAGAGTGACAGG PSEN2 ENSG00000143801 -0.22382175275394883 [496] [407,324,406,466] -4 hSpCas9 negative selection 9445153
226888958 226888981 1 + 27260156 TC32 viability CATCATGATCAGTGCGCTCATGG PSEN2 ENSG00000143801 -0.07432940208340191 [559] [565,287,601,609] -1 hSpCas9 negative selection 9445154
226889004 226889027 1 - 27260156 TC32 viability ATGACCCACGCGGACCACTCTGG PSEN2 ENSG00000143801 -0.31782739578134944 [296] [313,80,338,210] -5 hSpCas9 negative selection 9509411
226894023 226894046 1 - 27260156 TC32 viability TGTAGAAGATGAAGTCCCCGAGG PSEN2 ENSG00000143801 -0.28756181665241703 [354] [257,157,406,326] -5 hSpCas9 negative selection 9509412
226894000 226894023 1 + 27260156 TC32 viability CACACAGGGGGCGTGAAGCTTGG PSEN2 ENSG00000143801 -0.44927481873127495 [227] [133,79,221,230] -7 hSpCas9 negative selection 9509413
226881916 226881939 1 + 27869803 HPAFII viability after 27 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 -0.09510266737237316 [168] [158,19,NaN] 0 hSpCas9 negative selection 9532416
226883891 226883914 1 + 27869803 HPAFII viability after 27 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.5489025698728316 [709] [628,476,NaN] 4 hSpCas9 negative selection 9532417
226885594 226885617 1 - 27869803 HPAFII viability after 27 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 -0.1806452768519854 [438] [129,264,NaN] -1 hSpCas9 negative selection 9532418
226888096 226888119 1 - 27869803 HPAFII viability after 27 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 1.2710163668036965 [229] [251,324,NaN] 9 hSpCas9 negative selection 9532419
226888838 226888861 1 + 27869803 HPAFII viability after 27 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.19027058266559205 [380] [281,183,NaN] 1 hSpCas9 negative selection 9532420
226890072 226890095 1 + 27869803 HPAFII viability after 27 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -0.13425879944215913 [25] [12,11,NaN] -1 hSpCas9 negative selection 9532421
226881916 226881939 1 + 27869803 HPAFII viability after 15 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.21314960728008986 [168] [360,116,NaN] 2 hSpCas9 negative selection 9614865
226883891 226883914 1 + 27869803 HPAFII viability after 15 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.17698823507768924 [709] [1424,512,NaN] 2 hSpCas9 negative selection 9614866
226885594 226885617 1 - 27869803 HPAFII viability after 15 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.16818182919468283 [438] [613,477,NaN] 2 hSpCas9 negative selection 9614867
226888096 226888119 1 - 27869803 HPAFII viability after 15 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.6923640303294072 [229] [449,367,NaN] 7 hSpCas9 negative selection 9614868
226888838 226888861 1 + 27869803 HPAFII viability after 15 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.4045040557895908 [380] [623,490,NaN] 4 hSpCas9 negative selection 9614869
226890072 226890095 1 + 27869803 HPAFII viability after 15 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.4768648258158956 [25] [94,3,NaN] 5 hSpCas9 negative selection 9614870
226881916 226881939 1 + 27869803 ASPC1 viability after 36 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.47120657098232815 [472] [26,451,190] 5 hSpCas9 negative selection 9697314
226883891 226883914 1 + 27869803 ASPC1 viability after 36 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.2931401550086248 [1490] [587,978,394] 3 hSpCas9 negative selection 9697315
226885594 226885617 1 - 27869803 ASPC1 viability after 36 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 0.06599856385716907 [974] [456,112,474] 0 hSpCas9 negative selection 9697316
226888096 226888119 1 - 27869803 ASPC1 viability after 36 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 -0.1067904641219749 [627] [405,188,70] -1 hSpCas9 negative selection 9697317
226888838 226888861 1 + 27869803 ASPC1 viability after 36 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.07390312693736878 [913] [436,242,334] 0 hSpCas9 negative selection 9697318
226890072 226890095 1 + 27869803 ASPC1 viability after 36 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -0.8439149896491314 [100] [9,0,40] -7 hSpCas9 negative selection 9697319
226881916 226881939 1 + 27869803 PATU8988S viability after 35 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 -0.4977743451268064 [353] [87,113,NaN] -5 hSpCas9 negative selection 9779763
226883891 226883914 1 + 27869803 PATU8988S viability after 35 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.0568023367805357 [1275] [554,513,NaN] 0 hSpCas9 negative selection 9779764
226885594 226885617 1 - 27869803 PATU8988S viability after 35 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 -0.13898286709991786 [837] [309,302,NaN] -1 hSpCas9 negative selection 9779765
226888096 226888119 1 - 27869803 PATU8988S viability after 35 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.8234486325121291 [541] [295,476,NaN] 8 hSpCas9 negative selection 9779766
226888838 226888861 1 + 27869803 PATU8988S viability after 35 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.60684325713671 [677] [352,478,NaN] 6 hSpCas9 negative selection 9779767
226890072 226890095 1 + 27869803 PATU8988S viability after 35 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 1.5912397403848613 [82] [197,2,NaN] 9 hSpCas9 negative selection 9779768
226881916 226881939 1 + 27869803 PATU8988S viability after 31 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 0.022662473472958466 [353] [94,204,NaN] 0 hSpCas9 negative selection 9862212
226883891 226883914 1 + 27869803 PATU8988S viability after 31 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.22494796611443535 [1275] [635,541,NaN] 2 hSpCas9 negative selection 9862213
226885594 226885617 1 - 27869803 PATU8988S viability after 31 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 -0.0830037756129186 [837] [241,408,NaN] -1 hSpCas9 negative selection 9862214
226888096 226888119 1 - 27869803 PATU8988S viability after 31 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 0.4801532980976645 [541] [216,408,NaN] 6 hSpCas9 negative selection 9862215
226888838 226888861 1 + 27869803 PATU8988S viability after 31 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.7148571567738247 [677] [287,641,NaN] 8 hSpCas9 negative selection 9862216
226890072 226890095 1 + 27869803 PATU8988S viability after 31 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.4123456208012404 [82] [69,10,NaN] 5 hSpCas9 negative selection 9862217
226881916 226881939 1 + 27869803 HPAFII viability after 35 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 -0.3973006220121468 [168] [103,20,NaN] -2 hSpCas9 negative selection 9944661
226883891 226883914 1 + 27869803 HPAFII viability after 35 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.9095709196788486 [709] [709,635,NaN] 6 hSpCas9 negative selection 9944662
226885594 226885617 1 - 27869803 HPAFII viability after 35 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 -1.3347437131548876 [438] [73,103,NaN] -6 hSpCas9 negative selection 9944663
226888096 226888119 1 - 27869803 HPAFII viability after 35 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 1.5047857345653128 [229] [122,563,NaN] 8 hSpCas9 negative selection 9944664
226888838 226888861 1 + 27869803 HPAFII viability after 35 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.21189611041456735 [380] [189,260,NaN] 1 hSpCas9 negative selection 9944665
226890072 226890095 1 + 27869803 HPAFII viability after 35 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -2.4486793073884785 [25] [0,3,NaN] -8 hSpCas9 negative selection 9944666
226881916 226881939 1 + 27869803 HPAFII viability after 31 days ATTCATGGCCTCTGACAGCGAGG PSEN2 ENSG00000143801 -0.5846775954540274 [168] [90,32,NaN] -4 hSpCas9 negative selection 10027110
226883891 226883914 1 + 27869803 HPAFII viability after 31 days CGCTTCTACACAGAGAAGAATGG PSEN2 ENSG00000143801 0.6151214198212185 [709] [784,419,NaN] 4 hSpCas9 negative selection 10027111
226885594 226885617 1 - 27869803 HPAFII viability after 31 days CATGATGAGGGTGTTCAGCACGG PSEN2 ENSG00000143801 -0.9125420992870591 [438] [38,230,NaN] -5 hSpCas9 negative selection 10027112
226888096 226888119 1 - 27869803 HPAFII viability after 31 days AAGACATGATCAACCAGCCATGG PSEN2 ENSG00000143801 1.2629746893375444 [229] [181,448,NaN] 8 hSpCas9 negative selection 10027113
226888838 226888861 1 + 27869803 HPAFII viability after 31 days CAAGACCTACAATGTGGCCATGG PSEN2 ENSG00000143801 0.32654359356850726 [380] [192,349,NaN] 2 hSpCas9 negative selection 10027114
226890072 226890095 1 + 27869803 HPAFII viability after 31 days AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -0.44176268373316363 [25] [4,16,NaN] -3 hSpCas9 negative selection 10027115
226883704 226883727 1 + 28162770 P31FUJ viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -0.5611280704998916 [112] [89] -5 hSpCas9 negative selection 10218551
226885554 226885577 1 + 28162770 P31FUJ viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 0.006663730281010743 [215] [254] 0 hSpCas9 negative selection 10218552
226883874 226883897 1 - 28162770 P31FUJ viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 0.3213980425360905 [78] [115] 3 hSpCas9 negative selection 10218553
226882026 226882049 1 + 28162770 P31FUJ viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.6982504418681299 [149] [285] 7 hSpCas9 negative selection 10218554
226888867 226888890 1 - 28162770 P31FUJ viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -0.6895177349430931 [198] [144] -5 hSpCas9 negative selection 10218555
226888919 226888942 1 - 28162770 P31FUJ viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -1.999515141974637 [244] [71] -8 hSpCas9 negative selection 10218556
226890072 226890095 1 + 28162770 P31FUJ viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.6082082718244645 [229] [411] 7 hSpCas9 negative selection 10218557
226891315 226891338 1 - 28162770 P31FUJ viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -1.0318895104883823 [260] [149] -6 hSpCas9 negative selection 10218558
226883716 226883739 1 + 28162770 P31FUJ viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 0.4676375137267139 [15] [25] 5 hSpCas9 negative selection 10218559
226883746 226883769 1 - 28162770 P31FUJ viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 -0.08134986304354522 [261] [290] -1 hSpCas9 negative selection 10218560
226883704 226883727 1 + 28162770 TF1 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 NaN [NaN] [1] 1 hSpCas9 negative selection 10387917
226885554 226885577 1 + 28162770 TF1 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 NaN [NaN] [228] 1 hSpCas9 negative selection 10387918
226883874 226883897 1 - 28162770 TF1 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 NaN [NaN] [27] 1 hSpCas9 negative selection 10387919
226882026 226882049 1 + 28162770 TF1 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 NaN [NaN] [87] 1 hSpCas9 negative selection 10387920
226888867 226888890 1 - 28162770 TF1 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 NaN [NaN] [66] 1 hSpCas9 negative selection 10387921
226888919 226888942 1 - 28162770 TF1 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 NaN [NaN] [9] 1 hSpCas9 negative selection 10387922
226890072 226890095 1 + 28162770 TF1 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 NaN [NaN] [252] 1 hSpCas9 negative selection 10387923
226891315 226891338 1 - 28162770 TF1 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 NaN [NaN] [219] 1 hSpCas9 negative selection 10387924
226883716 226883739 1 + 28162770 TF1 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 NaN [NaN] [23] 1 hSpCas9 negative selection 10387925
226883746 226883769 1 - 28162770 TF1 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 NaN [NaN] [221] 1 hSpCas9 negative selection 10387926
226883704 226883727 1 + 28162770 SKM1 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -1.1268562795504264 [41] [33] -7 hSpCas9 negative selection 10557283
226885554 226885577 1 + 28162770 SKM1 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 0.3943162089047582 [33] [78] 4 hSpCas9 negative selection 10557284
226883874 226883897 1 - 28162770 SKM1 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 0.34792330342030686 [23] [53] 3 hSpCas9 negative selection 10557285
226882026 226882049 1 + 28162770 SKM1 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.4140656602115189 [44] [105] 4 hSpCas9 negative selection 10557286
226888867 226888890 1 - 28162770 SKM1 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -0.3987902672974616 [43] [58] -3 hSpCas9 negative selection 10557287
226888919 226888942 1 - 28162770 SKM1 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -3.332963617299385 [56] [9] -9 hSpCas9 negative selection 10557288
226890072 226890095 1 + 28162770 SKM1 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.6710383132581113 [53] [151] 6 hSpCas9 negative selection 10557289
226891315 226891338 1 - 28162770 SKM1 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -2.3663222142458156 [69] [23] -8 hSpCas9 negative selection 10557290
226883716 226883739 1 + 28162770 SKM1 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -1.8220016980220048 [1] [0] -8 hSpCas9 negative selection 10557291
226883746 226883769 1 - 28162770 SKM1 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 -0.44696226667508077 [63] [82] -4 hSpCas9 negative selection 10557292
226883704 226883727 1 + 28162770 SKM1 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -1.1268562795504264 [41] [33] -7 hSpCas9 negative selection 10726649
226885554 226885577 1 + 28162770 SKM1 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 0.3943162089047582 [33] [78] 4 hSpCas9 negative selection 10726650
226883874 226883897 1 - 28162770 SKM1 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 0.34792330342030686 [23] [53] 3 hSpCas9 negative selection 10726651
226882026 226882049 1 + 28162770 SKM1 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.4140656602115189 [44] [105] 4 hSpCas9 negative selection 10726652
226888867 226888890 1 - 28162770 SKM1 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -0.3987902672974616 [43] [58] -3 hSpCas9 negative selection 10726653
226888919 226888942 1 - 28162770 SKM1 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -3.332963617299385 [56] [9] -9 hSpCas9 negative selection 10726654
226890072 226890095 1 + 28162770 SKM1 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.6710383132581113 [53] [151] 6 hSpCas9 negative selection 10726655
226891315 226891338 1 - 28162770 SKM1 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -2.3663222142458156 [69] [23] -8 hSpCas9 negative selection 10726656
226883716 226883739 1 + 28162770 SKM1 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -1.8220016980220048 [1] [0] -8 hSpCas9 negative selection 10726657
226883746 226883769 1 - 28162770 SKM1 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 -0.44696226667508077 [63] [82] -4 hSpCas9 negative selection 10726658
226883704 226883727 1 + 28162770 PL21 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -0.259292004147977 [142] [51] -2 hSpCas9 negative selection 10896015
226885554 226885577 1 + 28162770 PL21 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 0.9106329972943351 [109] [89] 7 hSpCas9 negative selection 10896016
226883874 226883897 1 - 28162770 PL21 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 1.1006039409384056 [104] [97] 8 hSpCas9 negative selection 10896017
226882026 226882049 1 + 28162770 PL21 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 1.1648065413770394 [247] [241] 8 hSpCas9 negative selection 10896018
226888867 226888890 1 - 28162770 PL21 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -1.0510854890548402 [218] [45] -6 hSpCas9 negative selection 10896019
226888919 226888942 1 - 28162770 PL21 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -1.6564962103395027 [267] [36] -8 hSpCas9 negative selection 10896020
226890072 226890095 1 + 28162770 PL21 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.45845161008071084 [203] [121] 4 hSpCas9 negative selection 10896021
226891315 226891338 1 - 28162770 PL21 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -1.3294798523880609 [178] [30] -7 hSpCas9 negative selection 10896022
226883716 226883739 1 + 28162770 PL21 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -0.9153376029306166 [12] [2] -6 hSpCas9 negative selection 10896023
226883746 226883769 1 - 28162770 PL21 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.6184522458010249 [219] [146] 5 hSpCas9 negative selection 10896024
226883704 226883727 1 + 28162770 P31FUJ viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -0.5611280704998916 [112] [89] -5 hSpCas9 negative selection 11065381
226885554 226885577 1 + 28162770 P31FUJ viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 0.006663730281010743 [215] [254] 0 hSpCas9 negative selection 11065382
226883874 226883897 1 - 28162770 P31FUJ viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 0.3213980425360905 [78] [115] 3 hSpCas9 negative selection 11065383
226882026 226882049 1 + 28162770 P31FUJ viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.6982504418681299 [149] [285] 7 hSpCas9 negative selection 11065384
226888867 226888890 1 - 28162770 P31FUJ viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -0.6895177349430931 [198] [144] -5 hSpCas9 negative selection 11065385
226888919 226888942 1 - 28162770 P31FUJ viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -1.999515141974637 [244] [71] -8 hSpCas9 negative selection 11065386
226890072 226890095 1 + 28162770 P31FUJ viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.6082082718244645 [229] [411] 7 hSpCas9 negative selection 11065387
226891315 226891338 1 - 28162770 P31FUJ viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -1.0318895104883823 [260] [149] -6 hSpCas9 negative selection 11065388
226883716 226883739 1 + 28162770 P31FUJ viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 0.4676375137267139 [15] [25] 5 hSpCas9 negative selection 11065389
226883746 226883769 1 - 28162770 P31FUJ viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 -0.08134986304354522 [261] [290] -1 hSpCas9 negative selection 11065390
226883704 226883727 1 + 28162770 OCIAML5 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -0.8362992550056804 [90] [91] -5 hSpCas9 negative selection 11234747
226885554 226885577 1 + 28162770 OCIAML5 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 1.2859743695585295 [121] [536] 9 hSpCas9 negative selection 11234748
226883874 226883897 1 - 28162770 OCIAML5 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 -3.0135299935581132 [84] [18] -8 hSpCas9 negative selection 11234749
226882026 226882049 1 + 28162770 OCIAML5 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.9866525221029423 [77] [278] 8 hSpCas9 negative selection 11234750
226888867 226888890 1 - 28162770 OCIAML5 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 0.30101275914039205 [66] [148] 2 hSpCas9 negative selection 11234751
226888919 226888942 1 - 28162770 OCIAML5 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -1.9196298546766315 [152] [72] -7 hSpCas9 negative selection 11234752
226890072 226890095 1 + 28162770 OCIAML5 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.182980376235204 [121] [249] 1 hSpCas9 negative selection 11234753
226891315 226891338 1 - 28162770 OCIAML5 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 0.02367532617385734 [102] [188] 0 hSpCas9 negative selection 11234754
226883716 226883739 1 + 28162770 OCIAML5 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -0.8520665708639967 [0] [0] -5 hSpCas9 negative selection 11234755
226883746 226883769 1 - 28162770 OCIAML5 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 -0.37633313989759926 [191] [266] -3 hSpCas9 negative selection 11234756
226883704 226883727 1 + 28162770 EOL1 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -0.3908571997354934 [330] [132] -3 hSpCas9 negative selection 11404113
226885554 226885577 1 + 28162770 EOL1 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 1.5180217721472082 [168] [254] 9 hSpCas9 negative selection 11404114
226883874 226883897 1 - 28162770 EOL1 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 0.1171928495129303 [181] [103] 1 hSpCas9 negative selection 11404115
226882026 226882049 1 + 28162770 EOL1 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.11822889626545494 [347] [198] 1 hSpCas9 negative selection 11404116
226888867 226888890 1 - 28162770 EOL1 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -0.16006445614440679 [315] [148] -1 hSpCas9 negative selection 11404117
226888919 226888942 1 - 28162770 EOL1 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -1.724831457646392 [457] [72] -8 hSpCas9 negative selection 11404118
226890072 226890095 1 + 28162770 EOL1 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.522651371979757 [254] [192] 5 hSpCas9 negative selection 11404119
226891315 226891338 1 - 28162770 EOL1 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 0.40371560826909386 [263] [183] 3 hSpCas9 negative selection 11404120
226883716 226883739 1 + 28162770 EOL1 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -1.8828071504870696 [6] [0] -8 hSpCas9 negative selection 11404121
226883746 226883769 1 - 28162770 EOL1 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 -0.1749879019803798 [254] [118] -1 hSpCas9 negative selection 11404122
226883704 226883727 1 + 28162770 MOLM13 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -2.241061836452031 [254] [38] -7 hSpCas9 negative selection 11573479
226885554 226885577 1 + 28162770 MOLM13 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 0.4597615006611785 [177] [176] 3 hSpCas9 negative selection 11573480
226883874 226883897 1 - 28162770 MOLM13 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 -0.5093905419553377 [125] [63] -3 hSpCas9 negative selection 11573481
226882026 226882049 1 + 28162770 MOLM13 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 1.19035540601567 [259] [428] 8 hSpCas9 negative selection 11573482
226888867 226888890 1 - 28162770 MOLM13 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -0.028635154508993566 [260] [184] 0 hSpCas9 negative selection 11573483
226888919 226888942 1 - 28162770 MOLM13 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -3.157945400592105 [357] [28] -8 hSpCas9 negative selection 11573484
226890072 226890095 1 + 28162770 MOLM13 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.32791337211512334 [291] [264] 2 hSpCas9 negative selection 11573485
226891315 226891338 1 - 28162770 MOLM13 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -0.8965220446642971 [223] [86] -5 hSpCas9 negative selection 11573486
226883716 226883739 1 + 28162770 MOLM13 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -3.232550336596514 [12] [0] -8 hSpCas9 negative selection 11573487
226883746 226883769 1 - 28162770 MOLM13 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.42500356869140243 [477] [463] 3 hSpCas9 negative selection 11573488
226883704 226883727 1 + 28162770 HEL viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -0.3391138212893837 [157] [79] -2 hSpCas9 negative selection 11742845
226885554 226885577 1 + 28162770 HEL viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 -0.28944578377207153 [186] [97] -2 hSpCas9 negative selection 11742846
226883874 226883897 1 - 28162770 HEL viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 0.6780719051126377 [120] [123] 6 hSpCas9 negative selection 11742847
226882026 226882049 1 + 28162770 HEL viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 1.3392096479385036 [223] [362] 9 hSpCas9 negative selection 11742848
226888867 226888890 1 - 28162770 HEL viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 0.06559583573850014 [275] [184] 0 hSpCas9 negative selection 11742849
226888919 226888942 1 - 28162770 HEL viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -2.9801915189198196 [307] [24] -8 hSpCas9 negative selection 11742850
226890072 226890095 1 + 28162770 HEL viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.8591325127153617 [240] [279] 7 hSpCas9 negative selection 11742851
226891315 226891338 1 - 28162770 HEL viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -0.42203142338988087 [204] [97] -3 hSpCas9 negative selection 11742852
226883716 226883739 1 + 28162770 HEL viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -2.942223668720799 [11] [0] -8 hSpCas9 negative selection 11742853
226883746 226883769 1 - 28162770 HEL viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 -0.21496728553452132 [327] [180] -1 hSpCas9 negative selection 11742854
226883704 226883727 1 + 28162770 MV411 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -0.6165008996411963 [181] [99] -4 hSpCas9 negative selection 11912211
226885554 226885577 1 + 28162770 MV411 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 0.6534299104586121 [159] [211] 6 hSpCas9 negative selection 11912212
226883874 226883897 1 - 28162770 MV411 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 0.7949253460852688 [51] [75] 7 hSpCas9 negative selection 11912213
226882026 226882049 1 + 28162770 MV411 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.035933445589063584 [219] [189] 0 hSpCas9 negative selection 11912214
226888867 226888890 1 - 28162770 MV411 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -2.25240833630043 [180] [31] -8 hSpCas9 negative selection 11912215
226888919 226888942 1 - 28162770 MV411 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -2.532540932343524 [260] [37] -8 hSpCas9 negative selection 11912216
226890072 226890095 1 + 28162770 MV411 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.6566459712594215 [185] [246] 6 hSpCas9 negative selection 11912217
226891315 226891338 1 - 28162770 MV411 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 0.5330586416838095 [168] [205] 5 hSpCas9 negative selection 11912218
226883716 226883739 1 + 28162770 MV411 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -0.974954870553673 [6] [2] -6 hSpCas9 negative selection 11912219
226883746 226883769 1 - 28162770 MV411 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.6227749262413615 [174] [226] 5 hSpCas9 negative selection 11912220
226883704 226883727 1 + 28162770 MONOMAC1 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 0.1164626257572279 [102] [127] 1 hSpCas9 negative selection 12081577
226885554 226885577 1 + 28162770 MONOMAC1 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 -0.6219221322947448 [97] [72] -5 hSpCas9 negative selection 12081578
226883874 226883897 1 - 28162770 MONOMAC1 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 0.014467258134158056 [56] [65] 0 hSpCas9 negative selection 12081579
226882026 226882049 1 + 28162770 MONOMAC1 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.31850425270412297 [148] [212] 3 hSpCas9 negative selection 12081580
226888867 226888890 1 - 28162770 MONOMAC1 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -0.1970368470595539 [124] [124] -2 hSpCas9 negative selection 12081581
226888919 226888942 1 - 28162770 MONOMAC1 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -1.3715345782916903 [157] [69] -8 hSpCas9 negative selection 12081582
226890072 226890095 1 + 28162770 MONOMAC1 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.6134853540767334 [129] [227] 6 hSpCas9 negative selection 12081583
226891315 226891338 1 - 28162770 MONOMAC1 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -0.4627704024943027 [106] [88] -4 hSpCas9 negative selection 12081584
226883716 226883739 1 + 28162770 MONOMAC1 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -1.1970368470595538 [1] [0] -7 hSpCas9 negative selection 12081585
226883746 226883769 1 - 28162770 MONOMAC1 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 1.172608749405276 [112] [291] 8 hSpCas9 negative selection 12081586
226883704 226883727 1 + 28162770 OCIAML2 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -1.6108074832904216 [26] [48] -7 hSpCas9 negative selection 12250943
226885554 226885577 1 + 28162770 OCIAML2 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 0.5246166447872043 [37] [302] 5 hSpCas9 negative selection 12250944
226883874 226883897 1 - 28162770 OCIAML2 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 0.5737642941162922 [7] [65] 5 hSpCas9 negative selection 12250945
226882026 226882049 1 + 28162770 OCIAML2 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 0.2584736511510745 [45] [304] 2 hSpCas9 negative selection 12250946
226888867 226888890 1 - 28162770 OCIAML2 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -0.9274875002156321 [34] [101] -6 hSpCas9 negative selection 12250947
226888919 226888942 1 - 28162770 OCIAML2 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -2.541019153133559 [41] [39] -8 hSpCas9 negative selection 12250948
226890072 226890095 1 + 28162770 OCIAML2 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 -0.39848003948632593 [38] [163] -3 hSpCas9 negative selection 12250949
226891315 226891338 1 - 28162770 OCIAML2 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -1.3402331879864862 [36] [80] -7 hSpCas9 negative selection 12250950
226883716 226883739 1 + 28162770 OCIAML2 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 0.33672509681544227 [0] [6] 3 hSpCas9 negative selection 12250951
226883746 226883769 1 - 28162770 OCIAML2 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 0.5682891640501413 [31] [262] 5 hSpCas9 negative selection 12250952
226883704 226883727 1 + 28162770 OCIAML3 viability GAGAAGCCAGGAGAACGAGGAGG PSEN2 ENSG00000143801 -0.5820349986580872 [59] [120] -4 hSpCas9 negative selection 12420309
226885554 226885577 1 + 28162770 OCIAML3 viability ACTGAGGACACACCCTCGGTGGG PSEN2 ENSG00000143801 -0.4402023042451278 [39] [88] -3 hSpCas9 negative selection 12420310
226883874 226883897 1 - 28162770 OCIAML3 viability GAAGCGCACAGACTTGATGGTGG PSEN2 ENSG00000143801 -1.825333186430619 [26] [22] -8 hSpCas9 negative selection 12420311
226882026 226882049 1 + 28162770 OCIAML3 viability ATGGAGAGAACACTGCCCAGTGG PSEN2 ENSG00000143801 1.099014606254446 [29] [193] 8 hSpCas9 negative selection 12420312
226888867 226888890 1 - 28162770 OCIAML3 viability CCAGACAGTCAGCAAGAGGGTGG PSEN2 ENSG00000143801 -0.3681262329078353 [58] [137] -3 hSpCas9 negative selection 12420313
226888919 226888942 1 - 28162770 OCIAML3 viability GCACCAGAGGGCCCTTCCAGTGG PSEN2 ENSG00000143801 -1.9830499310700624 [54] [41] -8 hSpCas9 negative selection 12420314
226890072 226890095 1 + 28162770 OCIAML3 viability AATGCTGGTAGAAACTGCCCAGG PSEN2 ENSG00000143801 0.5612705851537478 [65] [293] 5 hSpCas9 negative selection 12420315
226891315 226891338 1 - 28162770 OCIAML3 viability GGAGGGCACCCTGAGAGGAGGGG PSEN2 ENSG00000143801 -1.165913988219873 [54] [73] -7 hSpCas9 negative selection 12420316
226883716 226883739 1 + 28162770 OCIAML3 viability GAACGAGGAGGACGGTGAGGAGG PSEN2 ENSG00000143801 -2.4013625623817676 [6] [3] -9 hSpCas9 negative selection 12420317
226883746 226883769 1 - 28162770 OCIAML3 viability GAACCCCACTACAGACATAGCGG PSEN2 ENSG00000143801 -0.746010733769213 [59] [107] -5 hSpCas9 negative selection 12420318