Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 6261
• Symbol: RYR1
• Description: ryanodine receptor 1

DataSource: http://genomecrispr.dkfz.de/#!/results/RYR1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
38442417	38442440	19	+	26472758	Jiyoye	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	2.729103476393236	[13]	[69]	9	hSpCas9	negative selection	141524
38440809	38440832	19	-	26472758	Jiyoye	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	-0.12716104614531476	[41]	[28]	-1	hSpCas9	negative selection	141525
38448415	38448438	19	+	26472758	Jiyoye	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	3.2916981640859375	[12]	[95]	9	hSpCas9	negative selection	141526
38448486	38448509	19	-	26472758	Jiyoye	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-1.9774884687294514	[93]	[17]	-8	hSpCas9	negative selection	141527
38485992	38486015	19	-	26472758	Jiyoye	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	0.3448911032515307	[141]	[135]	2	hSpCas9	negative selection	141528
38496483	38496506	19	-	26472758	Jiyoye	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	-0.22085584110716883	[50]	[32]	-1	hSpCas9	negative selection	141529
38505358	38505381	19	-	26472758	Jiyoye	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	-1.2221812385737363	[98]	[31]	-7	hSpCas9	negative selection	141530
38546480	38546503	19	+	26472758	Jiyoye	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-0.3297902126603327	[124]	[74]	-2	hSpCas9	negative selection	141531
38440735	38440758	19	+	26472758	Jiyoye	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	1.0195143211583346	[86]	[132]	6	hSpCas9	negative selection	141532
38442417	38442440	19	+	26472758	KBM7	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	0.9048102793145915	[258,101]	[93,204]	8	hSpCas9	negative selection	332642
38440809	38440832	19	-	26472758	KBM7	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	0.1799581972103932	[201,171]	[112,86]	1	hSpCas9	negative selection	332643
38448415	38448438	19	+	26472758	KBM7	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	0.5950658245028946	[428,382]	[276,297]	6	hSpCas9	negative selection	332644
38448486	38448509	19	-	26472758	KBM7	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-0.635506312775211	[159,102]	[36,40]	-5	hSpCas9	negative selection	332645
38485992	38486015	19	-	26472758	KBM7	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	0.15854819052736585	[597,544]	[328,273]	1	hSpCas9	negative selection	332646
38496483	38496506	19	-	26472758	KBM7	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	0.7741016974199866	[220,122]	[135,133]	8	hSpCas9	negative selection	332647
38505358	38505381	19	-	26472758	KBM7	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	-0.22433684867700138	[449,335]	[201,115]	-2	hSpCas9	negative selection	332648
38546480	38546503	19	+	26472758	KBM7	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-0.3924484616682037	[419,640]	[194,194]	-4	hSpCas9	negative selection	332649
38440735	38440758	19	+	26472758	KBM7	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	0.5020865593137412	[827,863]	[362,749]	5	hSpCas9	negative selection	332650
38442417	38442440	19	+	26472758	Raji	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	-0.5706883697390384	[95]	[14]	-4	hSpCas9	negative selection	523760
38440809	38440832	19	-	26472758	Raji	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	-1.2013691707660294	[108]	[10]	-7	hSpCas9	negative selection	523761
38448415	38448438	19	+	26472758	Raji	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	1.7217298428758498	[80]	[61]	9	hSpCas9	negative selection	523762
38448486	38448509	19	-	26472758	Raji	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-0.7576868845402922	[50]	[6]	-5	hSpCas9	negative selection	523763
38485992	38486015	19	-	26472758	Raji	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	-0.4161784206834136	[321]	[55]	-3	hSpCas9	negative selection	523764
38496483	38496506	19	-	26472758	Raji	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	-0.9941544910884628	[102]	[11]	-6	hSpCas9	negative selection	523765
38505358	38505381	19	-	26472758	Raji	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	-0.04948531324326655	[164]	[36]	0	hSpCas9	negative selection	523766
38546480	38546503	19	+	26472758	Raji	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-1.3076539639052442	[255]	[23]	-7	hSpCas9	negative selection	523767
38440735	38440758	19	+	26472758	Raji	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	-0.4594316186372972	[473]	[79]	-4	hSpCas9	negative selection	523768
38442417	38442440	19	+	26472758	K562	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	-1.5242557262270975	[183]	[53]	-6	hSpCas9	negative selection	714878
38440809	38440832	19	-	26472758	K562	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	-2.3405437730547094	[161]	[26]	-8	hSpCas9	negative selection	714879
38448415	38448438	19	+	26472758	K562	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	-0.5697898654322197	[210]	[119]	-4	hSpCas9	negative selection	714880
38448486	38448509	19	-	26472758	K562	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-1.4997423679039632	[66]	[19]	-6	hSpCas9	negative selection	714881
38485992	38486015	19	-	26472758	K562	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	0.017783082562659563	[453]	[387]	0	hSpCas9	negative selection	714882
38496483	38496506	19	-	26472758	K562	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	0.24441872766644668	[142]	[142]	1	hSpCas9	negative selection	714883
38505358	38505381	19	-	26472758	K562	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	-0.3293165176314553	[319]	[214]	-2	hSpCas9	negative selection	714884
38546480	38546503	19	+	26472758	K562	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-2.131315810916709	[518]	[99]	-7	hSpCas9	negative selection	714885
38440735	38440758	19	+	26472758	K562	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	0.36994960975030566	[571]	[623]	3	hSpCas9	negative selection	714886
38433835	38433858	19	+	26627737	DLD1	viability	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	0.7135419167888164	[199]	[121,89,95]	7	hSpCas9	negative selection	804541
38440843	38440866	19	+	26627737	DLD1	viability	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	0.039912393144240235	[436]	[100,145,169]	0	hSpCas9	negative selection	804542
38442395	38442418	19	-	26627737	DLD1	viability	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.411542385881172	[1433]	[371,239,386]	-4	hSpCas9	negative selection	804543
38443611	38443634	19	+	26627737	DLD1	viability	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	-0.014232804620567308	[992]	[424,302,208]	0	hSpCas9	negative selection	804544
38443775	38443798	19	+	26627737	DLD1	viability	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	0.3334974428375951	[725]	[325,243,285]	3	hSpCas9	negative selection	804545
38444654	38444677	19	-	26627737	DLD1	viability	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	1.2033030307974932	[236]	[237,171,110]	9	hSpCas9	negative selection	804546
38433835	38433858	19	+	26627737	GBM cells	viability after 5 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	0.24119503172921516	[182]	[108,122]	4	hSpCas9	negative selection	886856
38440843	38440866	19	+	26627737	GBM cells	viability after 5 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-0.28649963382563426	[198]	[84,89]	-4	hSpCas9	negative selection	886857
38442395	38442418	19	-	26627737	GBM cells	viability after 5 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	0.1765105749223712	[574]	[389,306]	3	hSpCas9	negative selection	886858
38443611	38443634	19	+	26627737	GBM cells	viability after 5 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	-0.07043591227412976	[325]	[175,156]	-1	hSpCas9	negative selection	886859
38443775	38443798	19	+	26627737	GBM cells	viability after 5 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	0.1476576231690857	[371]	[202,238]	2	hSpCas9	negative selection	886860
38444654	38444677	19	-	26627737	GBM cells	viability after 5 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.6196692418706328	[178]	[127,166]	8	hSpCas9	negative selection	886861
38433835	38433858	19	+	26627737	GBM cells	viability after 13 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	0.5586235642544152	[182]	[148,143]	7	hSpCas9	negative selection	969171
38440843	38440866	19	+	26627737	GBM cells	viability after 13 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-0.47020769387761685	[198]	[99,59]	-5	hSpCas9	negative selection	969172
38442395	38442418	19	-	26627737	GBM cells	viability after 13 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.14223197888424344	[574]	[285,279]	-2	hSpCas9	negative selection	969173
38443611	38443634	19	+	26627737	GBM cells	viability after 13 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	-0.18592248111742454	[325]	[176,137]	-2	hSpCas9	negative selection	969174
38443775	38443798	19	+	26627737	GBM cells	viability after 13 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	0.06625391256477542	[371]	[239,187]	0	hSpCas9	negative selection	969175
38444654	38444677	19	-	26627737	GBM cells	viability after 13 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	1.0216309387632032	[178]	[205,189]	9	hSpCas9	negative selection	969176
38433835	38433858	19	+	26627737	GBM cells	viability after 21 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	1.2208552325374975	[182]	[237,225]	9	hSpCas9	negative selection	1051486
38440843	38440866	19	+	26627737	GBM cells	viability after 21 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	0.26548317869477245	[198]	[130,128]	2	hSpCas9	negative selection	1051487
38442395	38442418	19	-	26627737	GBM cells	viability after 21 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.36726216696922664	[574]	[237,245]	-3	hSpCas9	negative selection	1051488
38443611	38443634	19	+	26627737	GBM cells	viability after 21 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	0.1037211294404159	[325]	[182,196]	1	hSpCas9	negative selection	1051489
38443775	38443798	19	+	26627737	GBM cells	viability after 21 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	-0.0770554266650294	[371]	[212,171]	0	hSpCas9	negative selection	1051490
38444654	38444677	19	-	26627737	GBM cells	viability after 21 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.9109781717323528	[178]	[197,168]	8	hSpCas9	negative selection	1051491
38433835	38433858	19	+	26627737	RPE1	viability after 9 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	-2.2099276692279934	[403]	[8,50]	-9	hSpCas9	negative selection	1133801
38440843	38440866	19	+	26627737	RPE1	viability after 9 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-1.3958364545421325	[1068]	[93,169]	-7	hSpCas9	negative selection	1133802
38442395	38442418	19	-	26627737	RPE1	viability after 9 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.025475677418646203	[2779]	[934,751]	0	hSpCas9	negative selection	1133803
38443611	38443634	19	+	26627737	RPE1	viability after 9 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	1.332718991362132	[460]	[249,509]	7	hSpCas9	negative selection	1133804
38443775	38443798	19	+	26627737	RPE1	viability after 9 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	-0.05807715064087554	[1082]	[350,292]	0	hSpCas9	negative selection	1133805
38444654	38444677	19	-	26627737	RPE1	viability after 9 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.26051973314478694	[672]	[230,279]	1	hSpCas9	negative selection	1133806
38433835	38433858	19	+	26627737	RPE1	viability after 12 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	0.024496290812149768	[403]	[55,167]	0	hSpCas9	negative selection	1216116
38440843	38440866	19	+	26627737	RPE1	viability after 12 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-1.571556798582336	[1068]	[100,91]	-8	hSpCas9	negative selection	1216117
38442395	38442418	19	-	26627737	RPE1	viability after 12 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.2537515506632406	[2779]	[623,628]	-2	hSpCas9	negative selection	1216118
38443611	38443634	19	+	26627737	RPE1	viability after 12 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	1.6186451724399258	[460]	[289,475]	8	hSpCas9	negative selection	1216119
38443775	38443798	19	+	26627737	RPE1	viability after 12 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	-0.2176033984275048	[1082]	[257,241]	-1	hSpCas9	negative selection	1216120
38444654	38444677	19	-	26627737	RPE1	viability after 12 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	-0.38059688109356415	[672]	[134,142]	-3	hSpCas9	negative selection	1216121
38433835	38433858	19	+	26627737	RPE1	viability after 15 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	-0.1689416173794226	[403]	[92,109]	-1	hSpCas9	negative selection	1298431
38440843	38440866	19	+	26627737	RPE1	viability after 15 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-0.6955163617006043	[1068]	[173,198]	-4	hSpCas9	negative selection	1298432
38442395	38442418	19	-	26627737	RPE1	viability after 15 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.010510049364923058	[2779]	[1022,546]	0	hSpCas9	negative selection	1298433
38443611	38443634	19	+	26627737	RPE1	viability after 15 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	1.8619793558868238	[460]	[246,692]	8	hSpCas9	negative selection	1298434
38443775	38443798	19	+	26627737	RPE1	viability after 15 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	-0.7078171221958047	[1082]	[211,163]	-4	hSpCas9	negative selection	1298435
38444654	38444677	19	-	26627737	RPE1	viability after 15 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.13266054947849837	[672]	[252,165]	0	hSpCas9	negative selection	1298436
38433835	38433858	19	+	26627737	RPE1	viability after 18 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	-1.15174180849731	[403]	[21,77]	-6	hSpCas9	negative selection	1380746
38440843	38440866	19	+	26627737	RPE1	viability after 18 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-1.499617407062832	[1068]	[58,147]	-7	hSpCas9	negative selection	1380747
38442395	38442418	19	-	26627737	RPE1	viability after 18 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.31977496011561435	[2779]	[792,395]	-2	hSpCas9	negative selection	1380748
38443611	38443634	19	+	26627737	RPE1	viability after 18 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	1.6962411273508855	[460]	[261,553]	8	hSpCas9	negative selection	1380749
38443775	38443798	19	+	26627737	RPE1	viability after 18 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	-1.0511130733778906	[1082]	[156,123]	-6	hSpCas9	negative selection	1380750
38444654	38444677	19	-	26627737	RPE1	viability after 18 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.25625256846529654	[672]	[170,265]	1	hSpCas9	negative selection	1380751
38433835	38433858	19	+	26627737	HeLa	viability after 8 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	0.9220963358037344	[219]	[220,151,179]	7	hSpCas9	negative selection	1463061
38440843	38440866	19	+	26627737	HeLa	viability after 8 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	1.6984207237790006	[122]	[225,108,195]	9	hSpCas9	negative selection	1463062
38442395	38442418	19	-	26627737	HeLa	viability after 8 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	0.029477944047029414	[1366]	[651,746,443]	0	hSpCas9	negative selection	1463063
38443611	38443634	19	+	26627737	HeLa	viability after 8 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	-0.1614663157277194	[653]	[313,156,301]	-1	hSpCas9	negative selection	1463064
38443775	38443798	19	+	26627737	HeLa	viability after 8 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	0.24346151948119543	[479]	[65,256,369]	2	hSpCas9	negative selection	1463065
38444654	38444677	19	-	26627737	HeLa	viability after 8 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.7671923678115771	[169]	[119,94,158]	6	hSpCas9	negative selection	1463066
38433835	38433858	19	+	26627737	HeLa	viability after 12 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	-0.4907966459148253	[219]	[126,44,25]	-4	hSpCas9	negative selection	1545376
38440843	38440866	19	+	26627737	HeLa	viability after 12 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	1.6869332736045415	[122]	[192,114,188]	9	hSpCas9	negative selection	1545377
38442395	38442418	19	-	26627737	HeLa	viability after 12 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.5447924361237324	[1366]	[380,288,501]	-5	hSpCas9	negative selection	1545378
38443611	38443634	19	+	26627737	HeLa	viability after 12 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	0.4794006940881663	[653]	[360,451,308]	4	hSpCas9	negative selection	1545379
38443775	38443798	19	+	26627737	HeLa	viability after 12 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	0.5339219882387358	[479]	[253,283,322]	4	hSpCas9	negative selection	1545380
38444654	38444677	19	-	26627737	HeLa	viability after 12 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.6509563484227211	[169]	[118,64,151]	5	hSpCas9	negative selection	1545381
38433835	38433858	19	+	26627737	HeLa	viability after 15 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	1.1147329905733008	[219]	[396,123,46]	7	hSpCas9	negative selection	1627691
38440843	38440866	19	+	26627737	HeLa	viability after 15 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	1.4686271580389139	[122]	[148,62,208]	8	hSpCas9	negative selection	1627692
38442395	38442418	19	-	26627737	HeLa	viability after 15 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.3195927944084864	[1366]	[294,498,553]	-3	hSpCas9	negative selection	1627693
38443611	38443634	19	+	26627737	HeLa	viability after 15 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	0.27660826792597115	[653]	[409,250,303]	2	hSpCas9	negative selection	1627694
38443775	38443798	19	+	26627737	HeLa	viability after 15 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	0.20398876286348616	[479]	[162,167,354]	1	hSpCas9	negative selection	1627695
38444654	38444677	19	-	26627737	HeLa	viability after 15 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	1.1267750195047321	[169]	[151,190,106]	7	hSpCas9	negative selection	1627696
38433835	38433858	19	+	26627737	HeLa	viability after 18 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	1.1249668224122766	[219]	[271,98,46]	7	hSpCas9	negative selection	1710006
38440843	38440866	19	+	26627737	HeLa	viability after 18 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	1.4882593663123473	[122]	[102,52,208]	8	hSpCas9	negative selection	1710007
38442395	38442418	19	-	26627737	HeLa	viability after 18 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.32840698016532754	[1366]	[191,413,553]	-3	hSpCas9	negative selection	1710008
38443611	38443634	19	+	26627737	HeLa	viability after 18 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	0.30582861709089126	[653]	[286,208,303]	2	hSpCas9	negative selection	1710009
38443775	38443798	19	+	26627737	HeLa	viability after 18 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	0.22864053676045026	[479]	[116,138,354]	2	hSpCas9	negative selection	1710010
38444654	38444677	19	-	26627737	HeLa	viability after 18 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	1.0803486736680397	[169]	[95,153,106]	7	hSpCas9	negative selection	1710011
38433835	38433858	19	+	26627737	HCT116	viability after 6 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	0.49934708513837545	[577]	[257,56]	2	hSpCas9	negative selection	1792321
38440843	38440866	19	+	26627737	HCT116	viability after 6 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	0.40122773689119257	[443]	[77,99]	2	hSpCas9	negative selection	1792322
38442395	38442418	19	-	26627737	HCT116	viability after 6 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	0.6426932317727139	[2272]	[738,457]	3	hSpCas9	negative selection	1792323
38443611	38443634	19	+	26627737	HCT116	viability after 6 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	0.5961203113725078	[1888]	[348,503]	3	hSpCas9	negative selection	1792324
38443775	38443798	19	+	26627737	HCT116	viability after 6 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	-1.0115653291811282	[1019]	[201,11]	-5	hSpCas9	negative selection	1792325
38444654	38444677	19	-	26627737	HCT116	viability after 6 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	-0.9044306644488828	[512]	[64,30]	-5	hSpCas9	negative selection	1792326
38433835	38433858	19	+	26627737	HCT116	viability after 8 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	0.09133907087010022	[267]	[162,144,163]	1	hSpCas9	negative selection	1874636
38440843	38440866	19	+	26627737	HCT116	viability after 8 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-0.3789362120042785	[347]	[96,156,186]	-4	hSpCas9	negative selection	1874637
38442395	38442418	19	-	26627737	HCT116	viability after 8 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.5789048049980215	[882]	[291,308,374]	-6	hSpCas9	negative selection	1874638
38443611	38443634	19	+	26627737	HCT116	viability after 8 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	0.3358050666287096	[352]	[270,308,157]	3	hSpCas9	negative selection	1874639
38443775	38443798	19	+	26627737	HCT116	viability after 8 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	0.8002761078673774	[349]	[319,328,357]	7	hSpCas9	negative selection	1874640
38444654	38444677	19	-	26627737	HCT116	viability after 8 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	-0.2698865647489746	[218]	[120,109,69]	-3	hSpCas9	negative selection	1874641
38433835	38433858	19	+	26627737	HCT116	viability after 9 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	-0.3628286709228823	[577]	[157,89]	-3	hSpCas9	negative selection	1956951
38440843	38440866	19	+	26627737	HCT116	viability after 9 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	0.13084067261182597	[443]	[288,3]	1	hSpCas9	negative selection	1956952
38442395	38442418	19	-	26627737	HCT116	viability after 9 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.20528759436862254	[2272]	[817,295]	-1	hSpCas9	negative selection	1956953
38443611	38443634	19	+	26627737	HCT116	viability after 9 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	-0.15109593037583036	[1888]	[408,489]	-1	hSpCas9	negative selection	1956954
38443775	38443798	19	+	26627737	HCT116	viability after 9 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	-0.20980797117269967	[1019]	[225,242]	-1	hSpCas9	negative selection	1956955
38444654	38444677	19	-	26627737	HCT116	viability after 9 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	-0.6547323224310359	[512]	[105,71]	-4	hSpCas9	negative selection	1956956
38433835	38433858	19	+	26627737	HCT116	viability after 12 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	-0.19612798050615865	[267]	[189,125,46]	-2	hSpCas9	negative selection	2039266
38440843	38440866	19	+	26627737	HCT116	viability after 12 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-0.18796046177296372	[347]	[71,184,232]	-2	hSpCas9	negative selection	2039267
38442395	38442418	19	-	26627737	HCT116	viability after 12 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	0.1156867770750114	[882]	[624,394,474]	1	hSpCas9	negative selection	2039268
38443611	38443634	19	+	26627737	HCT116	viability after 12 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	0.8403883767861147	[352]	[419,423,146]	7	hSpCas9	negative selection	2039269
38443775	38443798	19	+	26627737	HCT116	viability after 12 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	0.94642490006935	[349]	[350,243,465]	7	hSpCas9	negative selection	2039270
38444654	38444677	19	-	26627737	HCT116	viability after 12 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	-0.4982614361345747	[218]	[117,71,50]	-5	hSpCas9	negative selection	2039271
38433835	38433858	19	+	26627737	HCT116	viability after 15 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	0.12143558426559074	[267]	[317,67,134]	1	hSpCas9	negative selection	2121581
38440843	38440866	19	+	26627737	HCT116	viability after 15 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-0.6740517458840205	[347]	[80,131,156]	-6	hSpCas9	negative selection	2121582
38442395	38442418	19	-	26627737	HCT116	viability after 15 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	0.0626135485859074	[882]	[721,426,463]	0	hSpCas9	negative selection	2121583
38443611	38443634	19	+	26627737	HCT116	viability after 15 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	0.9301072776716077	[352]	[519,342,312]	7	hSpCas9	negative selection	2121584
38443775	38443798	19	+	26627737	HCT116	viability after 15 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	0.7388807404419039	[349]	[368,269,370]	6	hSpCas9	negative selection	2121585
38444654	38444677	19	-	26627737	HCT116	viability after 15 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	-0.009758433851570658	[218]	[156,123,97]	0	hSpCas9	negative selection	2121586
38433835	38433858	19	+	26627737	HCT116	viability after 18 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	-0.06823987960578812	[267]	[214,40,119]	0	hSpCas9	negative selection	2203896
38440843	38440866	19	+	26627737	HCT116	viability after 18 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-0.1018096494214985	[347]	[110,186,170]	-1	hSpCas9	negative selection	2203897
38442395	38442418	19	-	26627737	HCT116	viability after 18 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	0.21750429040994068	[882]	[391,513,585]	2	hSpCas9	negative selection	2203898
38443611	38443634	19	+	26627737	HCT116	viability after 18 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	1.2764060746967383	[352]	[381,581,257]	8	hSpCas9	negative selection	2203899
38443775	38443798	19	+	26627737	HCT116	viability after 18 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	1.2986742124122161	[349]	[564,181,521]	8	hSpCas9	negative selection	2203900
38444654	38444677	19	-	26627737	HCT116	viability after 18 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.5479984440719677	[218]	[168,177,113]	4	hSpCas9	negative selection	2203901
38539313	38539336	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCGCTGCAACCTCTGCCTCCTGG	RYR1	ENSG00000196218	-0.9365880081613079	[154,441]	[7,61]	-5	dCas9-VP64	positive selection	2389275
38438501	38438524	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	ACCTCAGCCTCCCGAGTAGCAGG	RYR1	ENSG00000196218	0.6074328335071536	[9,93]	[21,11]	2	dCas9-VP64	positive selection	2393289
38470124	38470147	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTGCCCAGGCTGGAGTGCAAGGG	RYR1	ENSG00000196218	-0.29783996533031276	[705,290]	[109,64]	-1	dCas9-VP64	positive selection	2393669
38571591	38571614	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	TGCACCACTACACTCCAGCCTAG	RYR1	ENSG00000196218	1.5534549579245929	[63,822]	[25,576]	6	dCas9-VP64	positive selection	2395520
38554374	38554397	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	TCACTGCAACCTCTAACTCCCGG	RYR1	ENSG00000196218	1.3898839408481742	[621,603]	[69,659]	5	dCas9-VP64	positive selection	2395838
38564407	38564430	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCCAGCTACTCAGGAGGCCGAGG	RYR1	ENSG00000196218	1.2848086487689858	[4,11]	[0,7]	5	dCas9-VP64	positive selection	2402925
38558634	38558657	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCATGTGCTACCACGCCAAG	RYR1	ENSG00000196218	3.748247150670283	[1,20]	[67,2]	9	dCas9-VP64	positive selection	2410081
38495407	38495430	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	AGGCTGCAGTGAGCTGTGATTGG	RYR1	ENSG00000196218	-0.2191175493670201	[259,121]	[39,30]	-1	dCas9-VP64	positive selection	2412048
38549345	38549368	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	AATTTGGGAGGCCGAGGTGGGAG	RYR1	ENSG00000196218	-0.2800147640918198	[48,6]	[5,2]	-1	dCas9-VP64	positive selection	2422594
38439232	38439255	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	GAGTTTCACTCTTGTTGCCCCAG	RYR1	ENSG00000196218	1.0342323942437988	[48,24]	[15,15]	4	dCas9-VP64	positive selection	2423060
38520537	38520560	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATACAAAAATTAGCCAGGCGTAG	RYR1	ENSG00000196218	0.7667043826941231	[92,346]	[53,113]	3	dCas9-VP64	positive selection	2426040
38436185	38436208	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGTGTGAGCCACCACGCCCGG	RYR1	ENSG00000196218	1.2080578617800355	[188,10]	[73,23]	5	dCas9-VP64	positive selection	2430251
38583202	38583225	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGAGAATCTCTTGAACCCCGG	RYR1	ENSG00000196218	0.7055876385115556	[3,484]	[1,182]	3	dCas9-VP64	positive selection	2452137
38539313	38539336	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCGCTGCAACCTCTGCCTCCTGG	RYR1	ENSG00000196218	-0.39148980799888866	[423,502]	[155,76]	-4	dCas9-VP64	positive selection	2484530
38438501	38438524	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	ACCTCAGCCTCCCGAGTAGCAGG	RYR1	ENSG00000196218	-0.7211613622673668	[190,191]	[45,29]	-7	dCas9-VP64	positive selection	2488544
38470124	38470147	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTGCCCAGGCTGGAGTGCAAGGG	RYR1	ENSG00000196218	-0.2409913144319511	[429,255]	[120,70]	-2	dCas9-VP64	positive selection	2488924
38571591	38571614	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	TGCACCACTACACTCCAGCCTAG	RYR1	ENSG00000196218	-0.4021395541078192	[270,438]	[81,91]	-4	dCas9-VP64	positive selection	2490775
38554374	38554397	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	TCACTGCAACCTCTAACTCCCGG	RYR1	ENSG00000196218	0.08036349274582033	[264,419]	[96,136]	0	dCas9-VP64	positive selection	2491093
38564407	38564430	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCCAGCTACTCAGGAGGCCGAGG	RYR1	ENSG00000196218	-0.42778639369274607	[66,93]	[18,18]	-4	dCas9-VP64	positive selection	2498180
38558634	38558657	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCATGTGCTACCACGCCAAG	RYR1	ENSG00000196218	-0.05566307319411967	[8,287]	[6,81]	0	dCas9-VP64	positive selection	2505336
38495407	38495430	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	AGGCTGCAGTGAGCTGTGATTGG	RYR1	ENSG00000196218	-0.13774130468097318	[186,55]	[21,49]	-1	dCas9-VP64	positive selection	2507303
38549345	38549368	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	AATTTGGGAGGCCGAGGTGGGAG	RYR1	ENSG00000196218	-0.15064112702583676	[301,462]	[54,164]	-1	dCas9-VP64	positive selection	2517849
38439232	38439255	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	GAGTTTCACTCTTGTTGCCCCAG	RYR1	ENSG00000196218	1.1207783393058013	[70,52]	[75,13]	7	dCas9-VP64	positive selection	2518315
38520537	38520560	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATACAAAAATTAGCCAGGCGTAG	RYR1	ENSG00000196218	0.15255249232697954	[139,139]	[73,28]	1	dCas9-VP64	positive selection	2521295
38436185	38436208	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGTGTGAGCCACCACGCCCGG	RYR1	ENSG00000196218	1.0270683763310697	[166,152]	[69,140]	6	dCas9-VP64	positive selection	2525506
38583202	38583225	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGAGAATCTCTTGAACCCCGG	RYR1	ENSG00000196218	-0.4319067453035411	[83,67]	[14,20]	-4	dCas9-VP64	positive selection	2547392
38469014	38469037	19	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ATACAGCCAACGACATCGCCCGG	RYR1	ENSG00000196218	-0.06412458953893252	[2,2]	[3,0]	-1	hSpCas9	positive selection	3018411
38448416	38448439	19	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	-0.5256973660450026	[2,2]	[2,0]	-6	hSpCas9	positive selection	3018412
38460573	38460596	19	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTACCTGGACAGTGTCCACAGGG	RYR1	ENSG00000196218	0.34217028982597486	[4,4]	[3,5]	7	hSpCas9	positive selection	3018413
38446494	38446517	19	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TATGTCCATGAAAGAGGCGGAGG	RYR1	ENSG00000196218	-0.48936458586441123	[3,3]	[3,0]	-6	hSpCas9	positive selection	3018414
38469014	38469037	19	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ATACAGCCAACGACATCGCCCGG	RYR1	ENSG00000196218	-0.23513884980897948	[2,2]	[2,0]	-3	hSpCas9	positive selection	3086269
38448416	38448439	19	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	-0.6743313785932724	[2,2]	[0,0]	-8	hSpCas9	positive selection	3086270
38460573	38460596	19	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTACCTGGACAGTGTCCACAGGG	RYR1	ENSG00000196218	-0.42408130417982254	[4,4]	[2,1]	-6	hSpCas9	positive selection	3086271
38446494	38446517	19	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TATGTCCATGAAAGAGGCGGAGG	RYR1	ENSG00000196218	-0.7535246462439349	[3,3]	[1,0]	-8	hSpCas9	positive selection	3086272
38444655	38444678		+	24336571	A375	resistance to PLX after 7 days	CATCTGCTCCCGCTGCGAAGAGG	RYR1	ENSG00000196218	-0.49408992269328905	[18,12]	[10,11]	-9	hSpCas9	positive selection	3142325
38446540	38446563		-	24336571	A375	resistance to PLX after 7 days	CGCTGGTCATCACTGTCAGCAGG	RYR1	ENSG00000196218	-0.48740297379012054	[18,19]	[11,14]	-9	hSpCas9	positive selection	3142326
38446544	38446567		+	24336571	A375	resistance to PLX after 7 days	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	-0.8080061578480596	[14,15]	[9,7]	-9	hSpCas9	positive selection	3142328
38444624	38444647		-	24336571	A375	resistance to PLX after 7 days	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	-0.06264561385418829	[13,16]	[15,12]	-2	hSpCas9	positive selection	3142329
38444655	38444678		+	24336571	A375	resistance to PLX after 14 days	CATCTGCTCCCGCTGCGAAGAGG	RYR1	ENSG00000196218	-0.6401490021615512	[18,14]	[3,4]	-7	hSpCas9	positive selection	3200118
38446540	38446563		-	24336571	A375	resistance to PLX after 14 days	CGCTGGTCATCACTGTCAGCAGG	RYR1	ENSG00000196218	1.2816866275981271	[14,18]	[22,15]	8	hSpCas9	positive selection	3200119
38446544	38446567		+	24336571	A375	resistance to PLX after 14 days	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.4770706509735711	[19,12]	[11,8]	4	hSpCas9	positive selection	3200121
38444624	38444647		-	24336571	A375	resistance to PLX after 14 days	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	-0.2536101193712575	[11,18]	[4,6]	-3	hSpCas9	positive selection	3200122
38444655	38444678		+	24336571	A375	viability after 7 days	CATCTGCTCCCGCTGCGAAGAGG	RYR1	ENSG00000196218	0.018066195563534115	[16]	[18,12]	0	hSpCas9	negative selection	3257911
38446540	38446563		-	24336571	A375	viability after 7 days	CGCTGGTCATCACTGTCAGCAGG	RYR1	ENSG00000196218	2.321146185080036	[3]	[18,19]	9	hSpCas9	negative selection	3257912
38446544	38446567		+	24336571	A375	viability after 7 days	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	2.488887747949081	[2]	[14,15]	9	hSpCas9	negative selection	3257914
38444624	38444647		-	24336571	A375	viability after 7 days	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.05560965482928626	[15]	[13,16]	0	hSpCas9	negative selection	3257915
38444655	38444678		+	24336571	A375	viability after 14 days	CATCTGCTCCCGCTGCGAAGAGG	RYR1	ENSG00000196218	0.09889542319671768	[16]	[18,14]	1	hSpCas9	negative selection	3315704
38446540	38446563		-	24336571	A375	viability after 14 days	CGCTGGTCATCACTGTCAGCAGG	RYR1	ENSG00000196218	2.1778305643927327	[3]	[14,18]	9	hSpCas9	negative selection	3315705
38446544	38446567		+	24336571	A375	viability after 14 days	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	2.5269050267421806	[2]	[19,12]	9	hSpCas9	negative selection	3315707
38444624	38444647		-	24336571	A375	viability after 14 days	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.07750307975089293	[15]	[11,18]	1	hSpCas9	negative selection	3315708
38446489	38446512	19	+	27383988	293T	resistance to West Nile virus (flavivirus)	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	-1.3573836326693731	[391,391]	[0,0]	-8	hSpCas9	positive selection	3391002
38446755	38446778	19	-	27383988	293T	resistance to West Nile virus (flavivirus)	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.01879819382840228	[154,154]	[0,0]	0	hSpCas9	positive selection	3391003
38446688	38446711	19	+	27383988	293T	resistance to West Nile virus (flavivirus)	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.5692222758450799	[226,226]	[0,0]	-4	hSpCas9	positive selection	3391004
38469014	38469037	19	-	26780180	HT29	viability (Avana library 4 designs)	ATACAGCCAACGACATCGCCCGG	RYR1	ENSG00000196218	1.76928465505239	[]	[]	6	hSpCas9	negative selection	3456809
38448415	38448438	19	+	26780180	HT29	viability (Avana library 4 designs)	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	1.96788179025432	[]	[]	7	hSpCas9	negative selection	3456810
38460573	38460596	19	-	26780180	HT29	viability (Avana library 4 designs)	GTACCTGGACAGTGTCCACAGGG	RYR1	ENSG00000196218	1.09334233264174	[]	[]	4	hSpCas9	negative selection	3456811
38446494	38446517	19	-	26780180	HT29	viability (Avana library 4 designs)	TATGTCCATGAAAGAGGCGGAGG	RYR1	ENSG00000196218	1.61394818449684	[]	[]	6	hSpCas9	negative selection	3456812
38460573	38460596	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTACCTGGACAGTGTCCACAGGG	RYR1	ENSG00000196218	1.76455644202122	[]	[]	2	hSpCas9	negative selection	3555460
38448415	38448438	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	2.9876105721327	[]	[]	4	hSpCas9	negative selection	3555461
38446494	38446517	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	TATGTCCATGAAAGAGGCGGAGG	RYR1	ENSG00000196218	3.51254461932062	[]	[]	5	hSpCas9	negative selection	3555462
38469014	38469037	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	ATACAGCCAACGACATCGCCCGG	RYR1	ENSG00000196218	0.294985044743401	[]	[]	0	hSpCas9	negative selection	3555463
38478492	38478515	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGGGCCGGATCAGCCACACGG	RYR1	ENSG00000196218	3.15355674882201	[]	[]	5	hSpCas9	negative selection	3555464
38483487	38483510	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	GATGGCGCTGCACATCCCCGAGG	RYR1	ENSG00000196218	3.9521655101413	[]	[]	6	hSpCas9	negative selection	3555465
38460573	38460596	19	-	26780180	A375	viability (Avana lentiGuide)	GTACCTGGACAGTGTCCACAGGG	RYR1	ENSG00000196218	7.50224613005379	[]	[]	6	hSpCas9	negative selection	3664119
38448415	38448438	19	+	26780180	A375	viability (Avana lentiGuide)	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	7.87097709548775	[]	[]	6	hSpCas9	negative selection	3664120
38446494	38446517	19	-	26780180	A375	viability (Avana lentiGuide)	TATGTCCATGAAAGAGGCGGAGG	RYR1	ENSG00000196218	2.38310884482199	[]	[]	2	hSpCas9	negative selection	3664121
38469014	38469037	19	-	26780180	A375	viability (Avana lentiGuide)	ATACAGCCAACGACATCGCCCGG	RYR1	ENSG00000196218	1.88434098143095	[]	[]	2	hSpCas9	negative selection	3664122
38478492	38478515	19	+	26780180	A375	viability (Avana lentiGuide)	GCAGGGCCGGATCAGCCACACGG	RYR1	ENSG00000196218	-0.17286955748663	[]	[]	0	hSpCas9	negative selection	3664123
38483487	38483510	19	+	26780180	A375	viability (Avana lentiGuide)	GATGGCGCTGCACATCCCCGAGG	RYR1	ENSG00000196218	11.7283126659264	[]	[]	7	hSpCas9	negative selection	3664124
38460573	38460596	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTACCTGGACAGTGTCCACAGGG	RYR1	ENSG00000196218	0.04248414469073197	[6]	[6,6]	1	hSpCas9	positive selection	3772726
38448415	38448438	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	0.15671288281287543	[4]	[5,4]	4	hSpCas9	positive selection	3772727
38446494	38446517	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TATGTCCATGAAAGAGGCGGAGG	RYR1	ENSG00000196218	-0.010294647529062083	[4]	[4,4]	0	hSpCas9	positive selection	3772728
38469014	38469037	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATACAGCCAACGACATCGCCCGG	RYR1	ENSG00000196218	0.0426553393931407	[4]	[5,4]	1	hSpCas9	positive selection	3772729
38478492	38478515	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGGGCCGGATCAGCCACACGG	RYR1	ENSG00000196218	0.030314483155384375	[4]	[5,2]	0	hSpCas9	positive selection	3772730
38483487	38483510	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GATGGCGCTGCACATCCCCGAGG	RYR1	ENSG00000196218	0.1865052610419663	[3]	[5,3]	5	hSpCas9	positive selection	3772731
38460573	38460596	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTACCTGGACAGTGTCCACAGGG	RYR1	ENSG00000196218	-0.187211686047159	[6]	[5,3]	-3	hSpCas9	positive selection	3881333
38448415	38448438	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	-0.47274243451577397	[4]	[4,1]	-6	hSpCas9	positive selection	3881334
38446494	38446517	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TATGTCCATGAAAGAGGCGGAGG	RYR1	ENSG00000196218	-0.3363181149497451	[5]	[2,3]	-4	hSpCas9	positive selection	3881335
38469014	38469037	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATACAGCCAACGACATCGCCCGG	RYR1	ENSG00000196218	-0.004813565519561025	[4]	[4,3]	0	hSpCas9	positive selection	3881336
38478492	38478515	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGGGCCGGATCAGCCACACGG	RYR1	ENSG00000196218	0.068731745435546	[4]	[3,4]	1	hSpCas9	positive selection	3881337
38483487	38483510	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GATGGCGCTGCACATCCCCGAGG	RYR1	ENSG00000196218	-0.3198826757580673	[4]	[2,2]	-4	hSpCas9	positive selection	3881338
38446489	38446512	19	+	26780180	A375	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.916532752088401	[]	[]	4	hSpCas9	negative selection	3991365
38444581	38444604	19	+	26780180	A375	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.962648683161089	[]	[]	4	hSpCas9	negative selection	3991366
38446688	38446711	19	+	26780180	A375	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	1.54531038143561	[]	[]	8	hSpCas9	negative selection	3991367
38446755	38446778	19	-	26780180	A375	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	1.49455558436242	[]	[]	8	hSpCas9	negative selection	3991368
38446544	38446567	19	+	26780180	A375	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.733180624530015	[]	[]	2	hSpCas9	negative selection	3991369
38444624	38444647	19	-	26780180	A375	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.82480059119075	[]	[]	3	hSpCas9	negative selection	3991370
38446489	38446512	19	+	26780180	HT29	viability (GeCKOv2 library)	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	1.2265913726962	[]	[]	6	hSpCas9	negative selection	4099331
38444581	38444604	19	+	26780180	HT29	viability (GeCKOv2 library)	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.764881735581964	[]	[]	3	hSpCas9	negative selection	4099332
38446688	38446711	19	+	26780180	HT29	viability (GeCKOv2 library)	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.639800751601471	[]	[]	2	hSpCas9	negative selection	4099333
38446755	38446778	19	-	26780180	HT29	viability (GeCKOv2 library)	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	1.62013604704561	[]	[]	8	hSpCas9	negative selection	4099334
38446544	38446567	19	+	26780180	HT29	viability (GeCKOv2 library)	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	1.57500768592245	[]	[]	8	hSpCas9	negative selection	4099335
38444624	38444647	19	-	26780180	HT29	viability (GeCKOv2 library)	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	1.00848278663681	[]	[]	4	hSpCas9	negative selection	4099336
38444655	38444678	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CATCTGCTCCCGCTGCGAAGAGG	RYR1	ENSG00000196218	-0.39083111178095303	[3]	[1,2]	-7	hSpCas9	positive selection	4168052
38446540	38446563	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGCTGGTCATCACTGTCAGCAGG	RYR1	ENSG00000196218	0.2952159814066111	[4]	[2,4]	7	hSpCas9	positive selection	4168053
38446544	38446567	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.04787035433116224	[3]	[1,3]	1	hSpCas9	positive selection	4168055
38444624	38444647	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	-0.16081705732811874	[4]	[2,2]	-4	hSpCas9	positive selection	4168056
38444655	38444678	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CATCTGCTCCCGCTGCGAAGAGG	RYR1	ENSG00000196218	-0.42108018617701404	[4]	[1,0,0,0]	-6	hSpCas9	positive selection	4232074
38446540	38446563	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGCTGGTCATCACTGTCAGCAGG	RYR1	ENSG00000196218	1.239561883956657	[4]	[3,4,2,5]	8	hSpCas9	positive selection	4232075
38446544	38446567	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.6698515079310119	[4]	[1,2,1,4]	4	hSpCas9	positive selection	4232077
38444624	38444647	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.09931139943980138	[3]	[1,2,2,0]	0	hSpCas9	positive selection	4232078
38446544	38446567	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.3292636641793619	[2]	[2,2]	6	hSpCas9	positive selection	4296151
38444624	38444647	19	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.29331705166137295	[2]	[3,2]	6	hSpCas9	positive selection	4296152
38444581	38444604	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.8498132610463636	[2]	[2,4]	9	hSpCas9	positive selection	4296153
38446489	38446512	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.2109818551465174	[4]	[4,3]	4	hSpCas9	positive selection	4360405
38446755	38446778	19	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.3050292711598824	[3]	[2,0]	-6	hSpCas9	positive selection	4360406
38446688	38446711	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.04769623269643897	[3]	[2,2]	1	hSpCas9	positive selection	4360407
38460487	38460509	19	+	27760321	OCIAML3	viability	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	0.471813381283419	[349,316]	[202,567]	5	hSpCas9	negative selection	4436512
38463490	38463512	19	+	27760321	OCIAML3	viability	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	0.27120299321652497	[820,654]	[480,967]	3	hSpCas9	negative selection	4436513
38486126	38486148	19	+	27760321	OCIAML3	viability	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	0.3578123861258581	[970,786]	[752,1036]	4	hSpCas9	negative selection	4436514
38494451	38494473	19	+	27760321	OCIAML3	viability	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	0.5312259647684747	[807,680]	[856,813]	6	hSpCas9	negative selection	4436515
38494487	38494509	19	-	27760321	OCIAML3	viability	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	0.26281172250340135	[704,703]	[545,815]	3	hSpCas9	negative selection	4436516
38460487	38460509	19	+	27760321	OCIAML2	viability	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	0.24053603612209215	[349,316]	[267,384]	3	hSpCas9	negative selection	4519975
38463490	38463512	19	+	27760321	OCIAML2	viability	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	0.3794724240169649	[820,654]	[623,966]	5	hSpCas9	negative selection	4519976
38486126	38486148	19	+	27760321	OCIAML2	viability	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	0.4164242032195983	[970,786]	[738,1213]	5	hSpCas9	negative selection	4519977
38494451	38494473	19	+	27760321	OCIAML2	viability	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	0.520155324175914	[807,680]	[743,1013]	7	hSpCas9	negative selection	4519978
38494487	38494509	19	-	27760321	OCIAML2	viability	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	0.24113589350326803	[704,703]	[563,822]	3	hSpCas9	negative selection	4519979
38460487	38460509	19	+	27760321	MV411	viability	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	-0.4180354582168324	[349,316]	[148,187]	-3	hSpCas9	negative selection	4603438
38463490	38463512	19	+	27760321	MV411	viability	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	-0.6747154378555207	[820,654]	[150,531]	-4	hSpCas9	negative selection	4603439
38486126	38486148	19	+	27760321	MV411	viability	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	-0.035563337526119176	[970,786]	[472,697]	0	hSpCas9	negative selection	4603440
38494451	38494473	19	+	27760321	MV411	viability	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	1.4395701562566545	[807,680]	[1614,895]	9	hSpCas9	negative selection	4603441
38494487	38494509	19	-	27760321	MV411	viability	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	0.463824211898747	[704,703]	[709,542]	3	hSpCas9	negative selection	4603442
38460487	38460509	19	+	27760321	HL60	viability	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	0.2333153300238702	[349,316]	[319,319]	3	hSpCas9	negative selection	4686901
38463490	38463512	19	+	27760321	HL60	viability	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	0.3178702515417571	[820,654]	[878,606]	4	hSpCas9	negative selection	4686902
38486126	38486148	19	+	27760321	HL60	viability	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	-0.15831470337105435	[970,786]	[672,604]	-2	hSpCas9	negative selection	4686903
38494451	38494473	19	+	27760321	HL60	viability	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	1.2431520557621383	[807,680]	[1177,1705]	9	hSpCas9	negative selection	4686904
38494487	38494509	19	-	27760321	HL60	viability	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	-0.10970690098129043	[704,703]	[553,514]	-1	hSpCas9	negative selection	4686905
38460487	38460509	19	+	27760321	HT1080	viability	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	-0.41127647734941375	[316,247]	[76,92]	-2	hSpCas9	negative selection	4770364
38463490	38463512	19	+	27760321	HT1080	viability	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	-0.26904931848766556	[654,510]	[165,221]	-1	hSpCas9	negative selection	4770365
38486126	38486148	19	+	27760321	HT1080	viability	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	0.3412104561526341	[786,613]	[300,410]	1	hSpCas9	negative selection	4770366
38494451	38494473	19	+	27760321	HT1080	viability	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	1.1218287207299307	[680,531]	[300,771]	6	hSpCas9	negative selection	4770367
38494487	38494509	19	-	27760321	HT1080	viability	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	0.689055768739546	[703,549]	[417,385]	3	hSpCas9	negative selection	4770368
38460487	38460509	19	+	27760321	HT29	viability after 7 days	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	0.395124599789698	[316,247]	[320,575,511]	6	hSpCas9	negative selection	4853827
38463490	38463512	19	+	27760321	HT29	viability after 7 days	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	0.24862337788876765	[654,510]	[1014,749,921]	4	hSpCas9	negative selection	4853828
38486126	38486148	19	+	27760321	HT29	viability after 7 days	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	0.16155551401123214	[786,613]	[969,680,1352]	2	hSpCas9	negative selection	4853829
38494451	38494473	19	+	27760321	HT29	viability after 7 days	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	0.2701095892200148	[680,531]	[826,919,1052]	4	hSpCas9	negative selection	4853830
38494487	38494509	19	-	27760321	HT29	viability after 7 days	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	-0.01808353001350005	[703,549]	[911,796,697]	0	hSpCas9	negative selection	4853831
38460487	38460509	19	+	27760321	HT29	viability after 25 days	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	0.15257658392078266	[316,247]	[283,264,551]	1	hSpCas9	negative selection	4937290
38463490	38463512	19	+	27760321	HT29	viability after 25 days	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	0.11486382325691058	[654,510]	[500,783,911]	1	hSpCas9	negative selection	4937291
38486126	38486148	19	+	27760321	HT29	viability after 25 days	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	-0.5010028295467575	[786,613]	[617,369,720]	-4	hSpCas9	negative selection	4937292
38494451	38494473	19	+	27760321	HT29	viability after 25 days	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	0.3279805687302483	[680,531]	[688,874,1077]	3	hSpCas9	negative selection	4937293
38494487	38494509	19	-	27760321	HT29	viability after 25 days	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	-0.6458682452523963	[703,549]	[532,338,500]	-5	hSpCas9	negative selection	4937294
38460487	38460509	19	+	27760321	HT29	viability after 22 days	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	-0.07040473816581205	[316,247]	[306,348,276]	0	hSpCas9	negative selection	5020753
38463490	38463512	19	+	27760321	HT29	viability after 22 days	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	0.016840753998620617	[654,510]	[487,967,593]	0	hSpCas9	negative selection	5020754
38486126	38486148	19	+	27760321	HT29	viability after 22 days	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	-0.12588684999535593	[786,613]	[807,629,786]	-1	hSpCas9	negative selection	5020755
38494451	38494473	19	+	27760321	HT29	viability after 22 days	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	0.5989256452358186	[680,531]	[1097,920,1166]	6	hSpCas9	negative selection	5020756
38494487	38494509	19	-	27760321	HT29	viability after 22 days	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	-0.22769208068470093	[703,549]	[630,482,743]	-2	hSpCas9	negative selection	5020757
38460487	38460509	19	+	27760321	HT29	viability after 19 days	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	0.5124085719864385	[316,247]	[302,522,536]	5	hSpCas9	negative selection	5104216
38463490	38463512	19	+	27760321	HT29	viability after 19 days	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	0.32781002127520775	[654,510]	[893,1054,576]	3	hSpCas9	negative selection	5104217
38486126	38486148	19	+	27760321	HT29	viability after 19 days	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	-0.3592132300302945	[786,613]	[944,530,437]	-3	hSpCas9	negative selection	5104218
38494451	38494473	19	+	27760321	HT29	viability after 19 days	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	0.807877783196321	[680,531]	[946,1202,1454]	8	hSpCas9	negative selection	5104219
38494487	38494509	19	-	27760321	HT29	viability after 19 days	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	-0.5659838927207003	[703,549]	[524,603,333]	-5	hSpCas9	negative selection	5104220
38460487	38460509	19	+	27760321	HT29	viability after 16 days	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	0.19727074916124765	[316,247]	[322,304,456]	2	hSpCas9	negative selection	5187679
38463490	38463512	19	+	27760321	HT29	viability after 16 days	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	0.3490868317860798	[654,510]	[725,959,792]	4	hSpCas9	negative selection	5187680
38486126	38486148	19	+	27760321	HT29	viability after 16 days	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	-0.5445790656612228	[786,613]	[369,690,530]	-5	hSpCas9	negative selection	5187681
38494451	38494473	19	+	27760321	HT29	viability after 16 days	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	0.585932336196178	[680,531]	[1214,601,1267]	6	hSpCas9	negative selection	5187682
38494487	38494509	19	-	27760321	HT29	viability after 16 days	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	-0.1949427218183709	[703,549]	[631,547,661]	-2	hSpCas9	negative selection	5187683
38460487	38460509	19	+	27760321	HT29	viability after 13 days	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	-0.0579798446511548	[316,247]	[276,324,340]	0	hSpCas9	negative selection	5271142
38463490	38463512	19	+	27760321	HT29	viability after 13 days	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	0.3917782445848961	[654,510]	[1044,839,782]	5	hSpCas9	negative selection	5271143
38486126	38486148	19	+	27760321	HT29	viability after 13 days	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	-0.06384142496041245	[786,613]	[985,691,660]	-1	hSpCas9	negative selection	5271144
38494451	38494473	19	+	27760321	HT29	viability after 13 days	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	0.5529876033909363	[680,531]	[1310,1039,761]	7	hSpCas9	negative selection	5271145
38494487	38494509	19	-	27760321	HT29	viability after 13 days	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	-0.3840001945319777	[703,549]	[577,533,559]	-4	hSpCas9	negative selection	5271146
38460487	38460509	19	+	27760321	HT29	viability after 10 days	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	-0.010871319377943556	[316,247]	[389,245,409]	0	hSpCas9	negative selection	5354605
38463490	38463512	19	+	27760321	HT29	viability after 10 days	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	-0.06689766419846943	[654,510]	[732,825,532]	-1	hSpCas9	negative selection	5354606
38486126	38486148	19	+	27760321	HT29	viability after 10 days	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	-0.054145529483158206	[786,613]	[869,749,902]	0	hSpCas9	negative selection	5354607
38494451	38494473	19	+	27760321	HT29	viability after 10 days	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	0.2628334470121686	[680,531]	[843,922,957]	3	hSpCas9	negative selection	5354608
38494487	38494509	19	-	27760321	HT29	viability after 10 days	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	0.11069606417158417	[703,549]	[799,988,752]	1	hSpCas9	negative selection	5354609
38460487	38460509	19	+	27760321	MOLM13	viability	ATCAAGGAGTATCGACGGGAGG	RYR1	ENSG00000196218	0.4539115779593005	[349,316]	[357,171]	3	hSpCas9	negative selection	5438068
38463490	38463512	19	+	27760321	MOLM13	viability	CGCTAACCCGCATCGAGCAGGG	RYR1	ENSG00000196218	0.1542621339376029	[820,654]	[633,312]	1	hSpCas9	negative selection	5438069
38486126	38486148	19	+	27760321	MOLM13	viability	AGCACGCTCGCGACCCCGTCGG	RYR1	ENSG00000196218	0.5281692351620441	[970,786]	[981,480]	3	hSpCas9	negative selection	5438070
38494451	38494473	19	+	27760321	MOLM13	viability	ACCGGCAGTACGACGGGCTGGG	RYR1	ENSG00000196218	0.32049487244672314	[807,680]	[581,471]	2	hSpCas9	negative selection	5438071
38494487	38494509	19	-	27760321	MOLM13	viability	ATGGTGTACGCCCGCGGCAGGG	RYR1	ENSG00000196218	0.37206816437843115	[704,703]	[467,556]	2	hSpCas9	negative selection	5438072
38433687	38433710	19	-	27661255	K562	viability	GCGAGGTAGATGGAACTGCGAGG	RYR1	ENSG00000196218	0.2983518880169468	[602,600]	[592,589]	8	dCas9-KRAB	negative selection	5509069
38433727	38433750	19	-	27661255	K562	viability	GGGCTGGGGTCGGAGACCTCTGG	RYR1	ENSG00000196218	-0.1032740554412388	[1424,1595]	[1229,1027]	-4	dCas9-KRAB	negative selection	5509070
38433784	38433807	19	-	27661255	K562	viability	GTCTGAGGTCGGGGAACAGAGGG	RYR1	ENSG00000196218	0.008698140409155675	[653,767]	[613,531]	0	dCas9-KRAB	negative selection	5509071
38434145	38434168	19	-	27661255	K562	viability	GTGAGGGTGTGCTCCCTCGGGGG	RYR1	ENSG00000196218	0.2833575064907153	[494,640]	[574,527]	8	dCas9-KRAB	negative selection	5509072
38446544	38446567	19	+	27260156	BXPC3	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.09544598814719224	[360]	[340,392,407,485]	2	hSpCas9	negative selection	5568611
38444624	38444647	19	-	27260156	BXPC3	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.48774199869905727	[438]	[496,703,707,678]	8	hSpCas9	negative selection	5568612
38444581	38444604	19	+	27260156	BXPC3	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.29153901814100786	[288]	[373,295,309,517]	6	hSpCas9	negative selection	5568613
38446489	38446512	19	+	27260156	BXPC3	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.012684086355066126	[1064]	[1041,1113,1147,1200]	0	hSpCas9	negative selection	5632865
38446755	38446778	19	-	27260156	BXPC3	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.01125737500485996	[553]	[548,538,571,648]	0	hSpCas9	negative selection	5632866
38446688	38446711	19	+	27260156	BXPC3	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.38682747233729886	[724]	[454,560,600,731]	-7	hSpCas9	negative selection	5632867
38446544	38446567	19	+	27260156	A673	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	-0.0004298021582064826	[360]	[422,415,407,487]	0	hSpCas9	negative selection	5689862
38444624	38444647	19	-	27260156	A673	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.4307696227642502	[438]	[731,640,768,701]	8	hSpCas9	negative selection	5689863
38444581	38444604	19	+	27260156	A673	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.2779824053324764	[288]	[538,428,345,379]	6	hSpCas9	negative selection	5689864
38446489	38446512	19	+	27260156	A673	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.08913765962661557	[1064]	[1552,1262,1255,1393]	2	hSpCas9	negative selection	5754116
38446755	38446778	19	-	27260156	A673	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.0424294322706647	[553]	[676,502,757,650]	-1	hSpCas9	negative selection	5754117
38446688	38446711	19	+	27260156	A673	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.13008073764227168	[724]	[849,819,700,816]	-3	hSpCas9	negative selection	5754118
38446544	38446567	19	+	27260156	A375	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.26687086273134686	[360]	[565,344,492,590]	4	hSpCas9	negative selection	5811113
38444624	38444647	19	-	27260156	A375	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.5207155850404638	[438]	[701,889,680,692]	7	hSpCas9	negative selection	5811114
38444581	38444604	19	+	27260156	A375	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.27994173898362357	[288]	[480,370,473,317]	4	hSpCas9	negative selection	5811115
38446489	38446512	19	+	27260156	A375	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.3012484319072084	[1064]	[1737,1383,1627,1374]	4	hSpCas9	negative selection	5875367
38446755	38446778	19	-	27260156	A375	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	0.004651499080895655	[553]	[700,889,609,450]	0	hSpCas9	negative selection	5875368
38446688	38446711	19	+	27260156	A375	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.012833776652015572	[724]	[688,1013,1033,714]	0	hSpCas9	negative selection	5875369
38446544	38446567	19	+	27260156	COLO741	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	-0.3389018325844981	[360]	[462,379,265]	-6	hSpCas9	negative selection	5932364
38444624	38444647	19	-	27260156	COLO741	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.31834071864116564	[438]	[683,706,703]	6	hSpCas9	negative selection	5932365
38444581	38444604	19	+	27260156	COLO741	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.17699491018417646	[288]	[474,388,393]	4	hSpCas9	negative selection	5932366
38446489	38446512	19	+	27260156	COLO741	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.2257717738713665	[1064]	[1567,1520,1672]	5	hSpCas9	negative selection	5996618
38446755	38446778	19	-	27260156	COLO741	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	0.1238136638031879	[553]	[727,773,803]	2	hSpCas9	negative selection	5996619
38446688	38446711	19	+	27260156	COLO741	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.01997822480500644	[724]	[878,735,1105]	0	hSpCas9	negative selection	5996620
38446544	38446567	19	+	27260156	CAL120	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.11272144950275409	[360]	[399,720,325]	1	hSpCas9	negative selection	6053615
38444624	38444647	19	-	27260156	CAL120	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.3188107536730588	[438]	[941,622,520]	5	hSpCas9	negative selection	6053616
38444581	38444604	19	+	27260156	CAL120	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.4936411710934104	[288]	[479,478,554]	7	hSpCas9	negative selection	6053617
38446489	38446512	19	+	27260156	CAL120	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.05351974684617056	[1064]	[1401,1546,1183]	0	hSpCas9	negative selection	6117869
38446755	38446778	19	-	27260156	CAL120	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	0.526655066951616	[553]	[1163,753,1084]	7	hSpCas9	negative selection	6117870
38446688	38446711	19	+	27260156	CAL120	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.2546836047040997	[724]	[1436,885,961]	4	hSpCas9	negative selection	6117871
38446544	38446567	19	+	27260156	CADOES1	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.19740538250647166	[360]	[476,307,306,449]	3	hSpCas9	negative selection	6174866
38444624	38444647	19	-	27260156	CADOES1	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.4141669884508532	[438]	[381,661,611,519]	7	hSpCas9	negative selection	6174867
38444581	38444604	19	+	27260156	CADOES1	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.15813677612517674	[288]	[282,356,332,223]	2	hSpCas9	negative selection	6174868
38446489	38446512	19	+	27260156	CADOES1	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.15447973276610472	[1064]	[1091,780,1232,1310]	2	hSpCas9	negative selection	6239120
38446755	38446778	19	-	27260156	CADOES1	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.35311694341009753	[553]	[297,350,399,570]	-6	hSpCas9	negative selection	6239121
38446688	38446711	19	+	27260156	CADOES1	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.03349166462306952	[724]	[653,596,728,654]	0	hSpCas9	negative selection	6239122
38446544	38446567	19	+	27260156	EWS502	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.28013640513120985	[360]	[441,530,509,365]	5	hSpCas9	negative selection	6296117
38444624	38444647	19	-	27260156	EWS502	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.43540605119984255	[438]	[593,450,777,708]	7	hSpCas9	negative selection	6296118
38444581	38444604	19	+	27260156	EWS502	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.30180111900265133	[288]	[290,269,564,400]	5	hSpCas9	negative selection	6296119
38446489	38446512	19	+	27260156	EWS502	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.22783399663127835	[1064]	[1042,1288,1403,1598]	4	hSpCas9	negative selection	6360371
38446755	38446778	19	-	27260156	EWS502	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.07282472328270168	[553]	[458,497,478,825]	-1	hSpCas9	negative selection	6360372
38446688	38446711	19	+	27260156	EWS502	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.08470049582304506	[724]	[608,765,712,824]	-1	hSpCas9	negative selection	6360373
38446544	38446567	19	+	27260156	EW8	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.07242799797597277	[360]	[438,217,323,259]	1	hSpCas9	negative selection	6417368
38444624	38444647	19	-	27260156	EW8	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.13420852446466452	[438]	[432,532,279,338]	2	hSpCas9	negative selection	6417369
38444581	38444604	19	+	27260156	EW8	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	-0.061217198165122166	[288]	[229,271,207,190]	-1	hSpCas9	negative selection	6417370
38446489	38446512	19	+	27260156	EW8	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.030007800636955517	[1064]	[985,938,674,968]	0	hSpCas9	negative selection	6481622
38446755	38446778	19	-	27260156	EW8	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.41840534595193	[553]	[325,358,208,468]	-6	hSpCas9	negative selection	6481623
38446688	38446711	19	+	27260156	EW8	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.8576168777600055	[724]	[378,375,249,309]	-9	hSpCas9	negative selection	6481624
38446544	38446567	19	+	27260156	CORL105	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	-0.07706506612545694	[360]	[382,377,568,298]	-1	hSpCas9	negative selection	6538619
38444624	38444647	19	-	27260156	CORL105	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.20797420710918055	[438]	[536,657,717,477]	4	hSpCas9	negative selection	6538620
38444581	38444604	19	+	27260156	CORL105	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.01666940958621077	[288]	[418,291,231,411]	0	hSpCas9	negative selection	6538621
38446489	38446512	19	+	27260156	CORL105	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	-0.062217432003168316	[1064]	[1261,1131,1351,1058]	-1	hSpCas9	negative selection	6602873
38446755	38446778	19	-	27260156	CORL105	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.30350262284374246	[553]	[424,473,557,646]	-5	hSpCas9	negative selection	6602874
38446688	38446711	19	+	27260156	CORL105	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.018212430695011328	[724]	[749,783,1065,785]	0	hSpCas9	negative selection	6602875
38446544	38446567	19	+	27260156	HS294T	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.05341625228672148	[360]	[111,191,133,141]	0	hSpCas9	negative selection	6659870
38444624	38444647	19	-	27260156	HS294T	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.7886629039888632	[438]	[392,291,254,207]	8	hSpCas9	negative selection	6659871
38444581	38444604	19	+	27260156	HS294T	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.6881083775494963	[288]	[178,265,114,151]	8	hSpCas9	negative selection	6659872
38446489	38446512	19	+	27260156	HS294T	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.004236796133142429	[1064]	[407,419,273,575]	0	hSpCas9	negative selection	6724124
38446755	38446778	19	-	27260156	HS294T	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.4734703184269781	[553]	[134,151,134,204]	-6	hSpCas9	negative selection	6724125
38446688	38446711	19	+	27260156	HS294T	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.2681170310491747	[724]	[257,375,321,411]	3	hSpCas9	negative selection	6724126
38446544	38446567	19	+	27260156	HCC44	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.1911467559441583	[360]	[522,294,667,439]	3	hSpCas9	negative selection	6781121
38444624	38444647	19	-	27260156	HCC44	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.528155246017733	[438]	[1083,572,816,463]	8	hSpCas9	negative selection	6781122
38444581	38444604	19	+	27260156	HCC44	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.8296879831484759	[288]	[779,354,575,654]	9	hSpCas9	negative selection	6781123
38446489	38446512	19	+	27260156	HCC44	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.17029750165900293	[1064]	[1321,1358,1548,1214]	2	hSpCas9	negative selection	6845375
38446755	38446778	19	-	27260156	HCC44	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	0.32622566346664006	[553]	[779,759,1136,530]	5	hSpCas9	negative selection	6845376
38446688	38446711	19	+	27260156	HCC44	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.23236962202699474	[724]	[1484,739,902,791]	4	hSpCas9	negative selection	6845377
38446544	38446567	19	+	27260156	G402	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.006836605119324102	[360]	[433,571,391,379]	0	hSpCas9	negative selection	6902372
38444624	38444647	19	-	27260156	G402	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.27908166875384893	[438]	[491,634,801,644]	3	hSpCas9	negative selection	6902373
38444581	38444604	19	+	27260156	G402	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	-0.11296774657556508	[288]	[235,239,460,346]	-1	hSpCas9	negative selection	6902374
38446489	38446512	19	+	27260156	G402	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.30121587848329723	[1064]	[1097,1306,2006,1882]	4	hSpCas9	negative selection	6966626
38446755	38446778	19	-	27260156	G402	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.3932840142531011	[553]	[666,521,455,437]	-5	hSpCas9	negative selection	6966627
38446688	38446711	19	+	27260156	G402	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.04567456481838039	[724]	[812,1124,719,779]	0	hSpCas9	negative selection	6966628
38446544	38446567	19	+	27260156	L33	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.08287367576877352	[360]	[340,249,197,264]	1	hSpCas9	negative selection	7023623
38444624	38444647	19	-	27260156	L33	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.37066796556765746	[438]	[581,216,388,539]	7	hSpCas9	negative selection	7023624
38444581	38444604	19	+	27260156	L33	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.15978494979522995	[288]	[246,121,261,331]	3	hSpCas9	negative selection	7023625
38446489	38446512	19	+	27260156	L33	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	-0.1624015075146914	[1064]	[931,385,569,1024]	-4	hSpCas9	negative selection	7087877
38446755	38446778	19	-	27260156	L33	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	0.13180927364013553	[553]	[617,268,344,603]	3	hSpCas9	negative selection	7087878
38446688	38446711	19	+	27260156	L33	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.047862383535839714	[724]	[898,279,377,808]	1	hSpCas9	negative selection	7087879
38446544	38446567	19	+	27260156	K562	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.017679261761904208	[360]	[358,404,318,230]	0	hSpCas9	negative selection	7144874
38444624	38444647	19	-	27260156	K562	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.7363432671532056	[438]	[994,276,915,438]	8	hSpCas9	negative selection	7144875
38444581	38444604	19	+	27260156	K562	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.40928623115459783	[288]	[298,299,364,385]	5	hSpCas9	negative selection	7144876
38446489	38446512	19	+	27260156	K562	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.1841005496900785	[1064]	[1029,1020,1073,1149]	2	hSpCas9	negative selection	7209128
38446755	38446778	19	-	27260156	K562	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.4725937231845454	[553]	[481,297,286,355]	-5	hSpCas9	negative selection	7209129
38446688	38446711	19	+	27260156	K562	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.5275970251065885	[724]	[531,306,364,564]	-6	hSpCas9	negative selection	7209130
38446544	38446567	19	+	27260156	HT29	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.20777811844024657	[360]	[453,678,409,492]	4	hSpCas9	negative selection	7266125
38444624	38444647	19	-	27260156	HT29	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	-0.024711553451894575	[438]	[658,630,469,372]	0	hSpCas9	negative selection	7266126
38444581	38444604	19	+	27260156	HT29	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.20220838729395807	[288]	[402,567,353,313]	4	hSpCas9	negative selection	7266127
38446489	38446512	19	+	27260156	HT29	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	-0.07032066501580791	[1064]	[1193,1212,1175,1323]	-1	hSpCas9	negative selection	7330379
38446755	38446778	19	-	27260156	HT29	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.1936203448531241	[553]	[578,701,542,541]	-4	hSpCas9	negative selection	7330380
38446688	38446711	19	+	27260156	HT29	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.10302704120205708	[724]	[851,628,993,790]	-2	hSpCas9	negative selection	7330381
38446544	38446567	19	+	27260156	MHHES1	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.1319396501062875	[360]	[376,496,531,378]	2	hSpCas9	negative selection	7387376
38444624	38444647	19	-	27260156	MHHES1	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.6326132928382686	[438]	[718,799,1023,554]	9	hSpCas9	negative selection	7387377
38444581	38444604	19	+	27260156	MHHES1	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.21281711153537425	[288]	[340,585,414,213]	4	hSpCas9	negative selection	7387378
38446489	38446512	19	+	27260156	MHHES1	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.14368964016200958	[1064]	[1509,1499,1360,1012]	2	hSpCas9	negative selection	7451630
38446755	38446778	19	-	27260156	MHHES1	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.0022708106736459843	[553]	[580,586,652,642]	0	hSpCas9	negative selection	7451631
38446688	38446711	19	+	27260156	MHHES1	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.03388455693729642	[724]	[950,825,723,711]	0	hSpCas9	negative selection	7451632
38446544	38446567	19	+	27260156	MEWO	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	-0.16813445038846003	[360]	[320,226,357]	-4	hSpCas9	negative selection	7508627
38444624	38444647	19	-	27260156	MEWO	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.5404407258891072	[438]	[561,608,613]	9	hSpCas9	negative selection	7508628
38444581	38444604	19	+	27260156	MEWO	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.25698788143764734	[288]	[433,261,294]	5	hSpCas9	negative selection	7508629
38446489	38446512	19	+	27260156	MEWO	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	-0.0712979719330038	[1064]	[1143,883,854]	-1	hSpCas9	negative selection	7572881
38446755	38446778	19	-	27260156	MEWO	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	0.07086535164374416	[553]	[604,504,534]	1	hSpCas9	negative selection	7572882
38446688	38446711	19	+	27260156	MEWO	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.05119716566822341	[724]	[817,532,644]	-1	hSpCas9	negative selection	7572883
38446544	38446567	19	+	27260156	LNCAPCLONEFGC	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	-0.3856123742872611	[360]	[201,252,311,243]	-5	hSpCas9	negative selection	7629878
38444624	38444647	19	-	27260156	LNCAPCLONEFGC	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.4032303506515531	[438]	[471,518,668,465]	6	hSpCas9	negative selection	7629879
38444581	38444604	19	+	27260156	LNCAPCLONEFGC	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.44118361197431427	[288]	[296,372,432,329]	7	hSpCas9	negative selection	7629880
38446489	38446512	19	+	27260156	LNCAPCLONEFGC	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.09564384399502135	[1064]	[920,839,1168,1227]	1	hSpCas9	negative selection	7694132
38446755	38446778	19	-	27260156	LNCAPCLONEFGC	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.08113944519436617	[553]	[468,520,431,465]	-1	hSpCas9	negative selection	7694133
38446688	38446711	19	+	27260156	LNCAPCLONEFGC	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.08686751525610092	[724]	[607,520,579,764]	-1	hSpCas9	negative selection	7694134
38446544	38446567	19	+	27260156	PANC0327	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	-0.2862311348141155	[360]	[186,303,152,395]	-4	hSpCas9	negative selection	7751129
38444624	38444647	19	-	27260156	PANC0327	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.7950436280194317	[438]	[879,807,544,472]	9	hSpCas9	negative selection	7751130
38444581	38444604	19	+	27260156	PANC0327	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.07257803126873186	[288]	[381,136,225,360]	1	hSpCas9	negative selection	7751131
38446489	38446512	19	+	27260156	PANC0327	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.0788253623752524	[1064]	[1175,802,919,1136]	1	hSpCas9	negative selection	7815383
38446755	38446778	19	-	27260156	PANC0327	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.26991510984996214	[553]	[324,413,466,418]	-4	hSpCas9	negative selection	7815384
38446688	38446711	19	+	27260156	PANC0327	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.19005524645818356	[724]	[666,364,549,709]	-3	hSpCas9	negative selection	7815385
38446544	38446567	19	+	27260156	NCIH2009	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.3672399827800796	[360]	[808,537,636]	5	hSpCas9	negative selection	7872380
38444624	38444647	19	-	27260156	NCIH2009	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.49098240904748847	[438]	[818,919,835]	6	hSpCas9	negative selection	7872381
38444581	38444604	19	+	27260156	NCIH2009	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.6517455962700863	[288]	[697,721,492]	8	hSpCas9	negative selection	7872382
38446489	38446512	19	+	27260156	NCIH2009	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.1088942508205275	[1064]	[1875,1593,1394]	1	hSpCas9	negative selection	7936634
38446755	38446778	19	-	27260156	NCIH2009	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.3206221322148043	[553]	[845,619,436]	-4	hSpCas9	negative selection	7936635
38446688	38446711	19	+	27260156	NCIH2009	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.271482592882036	[724]	[1669,1020,1066]	4	hSpCas9	negative selection	7936636
38446544	38446567	19	+	27260156	NCIH1373	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.12345153307808204	[360]	[480,363,368,149]	1	hSpCas9	negative selection	7993631
38444624	38444647	19	-	27260156	NCIH1373	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	-0.3940199439657557	[438]	[611,264,313,92]	-4	hSpCas9	negative selection	7993632
38444581	38444604	19	+	27260156	NCIH1373	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.312751684121734	[288]	[380,346,217,179]	3	hSpCas9	negative selection	7993633
38446489	38446512	19	+	27260156	NCIH1373	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.36768462953615977	[1064]	[1730,1426,1219,483]	3	hSpCas9	negative selection	8057885
38446755	38446778	19	-	27260156	NCIH1373	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	0.17043176485259573	[553]	[476,320,401,436]	1	hSpCas9	negative selection	8057886
38446688	38446711	19	+	27260156	NCIH1373	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.013953798554116936	[724]	[1376,536,697,205]	0	hSpCas9	negative selection	8057887
38446544	38446567	19	+	27260156	PATU8902	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.2193093161661194	[360]	[407,483,487,1037]	2	hSpCas9	negative selection	8114882
38444624	38444647	19	-	27260156	PATU8902	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.8664853009073579	[438]	[1057,1330,839,1317]	8	hSpCas9	negative selection	8114883
38444581	38444604	19	+	27260156	PATU8902	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.5469980026565889	[288]	[610,513,606,612]	6	hSpCas9	negative selection	8114884
38446489	38446512	19	+	27260156	PATU8902	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	-0.12524497781028976	[1064]	[880,1726,1166,1758]	-1	hSpCas9	negative selection	8179136
38446755	38446778	19	-	27260156	PATU8902	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.2425636620883406	[553]	[733,656,590,633]	-2	hSpCas9	negative selection	8179137
38446688	38446711	19	+	27260156	PATU8902	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.189629825538974	[724]	[655,1245,618,1113]	-2	hSpCas9	negative selection	8179138
38446544	38446567	19	+	27260156	PANC1	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.3117955848933699	[360]	[320,342,440,415]	5	hSpCas9	negative selection	8236133
38444624	38444647	19	-	27260156	PANC1	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.8710464986572177	[438]	[882,892,610,438]	9	hSpCas9	negative selection	8236134
38444581	38444604	19	+	27260156	PANC1	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.20380375244276255	[288]	[396,265,219,253]	3	hSpCas9	negative selection	8236135
38446489	38446512	19	+	27260156	PANC1	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	-0.027683639963898887	[1064]	[638,1330,937,780]	0	hSpCas9	negative selection	8300387
38446755	38446778	19	-	27260156	PANC1	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	0.17944976540652	[553]	[559,369,490,667]	3	hSpCas9	negative selection	8300388
38446688	38446711	19	+	27260156	PANC1	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.03038835474736623	[724]	[610,803,514,636]	0	hSpCas9	negative selection	8300389
38446544	38446567	19	+	27260156	PANC0813	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	-0.12845951115904392	[360]	[301,424,440,375]	-2	hSpCas9	negative selection	8357384
38444624	38444647	19	-	27260156	PANC0813	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.665792893119048	[438]	[1060,860,704,673]	9	hSpCas9	negative selection	8357385
38444581	38444604	19	+	27260156	PANC0813	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.4213777831444462	[288]	[646,381,418,390]	6	hSpCas9	negative selection	8357386
38446489	38446512	19	+	27260156	PANC0813	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	-0.09010796083912909	[1064]	[1240,1131,1052,1272]	-1	hSpCas9	negative selection	8421638
38446755	38446778	19	-	27260156	PANC0813	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.05764755651080297	[553]	[593,735,478,683]	-1	hSpCas9	negative selection	8421639
38446688	38446711	19	+	27260156	PANC0813	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.036236728824869724	[724]	[870,906,822,728]	0	hSpCas9	negative selection	8421640
38446544	38446567	19	+	27260156	RDES	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.037913556920795066	[360]	[328,327,506,586]	0	hSpCas9	negative selection	8478635
38444624	38444647	19	-	27260156	RDES	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.492206828489373	[438]	[537,682,761,908]	7	hSpCas9	negative selection	8478636
38444581	38444604	19	+	27260156	RDES	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.5898512949627192	[288]	[385,522,464,656]	8	hSpCas9	negative selection	8478637
38446489	38446512	19	+	27260156	RDES	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.39310213209875844	[1064]	[1390,1388,1931,1777]	6	hSpCas9	negative selection	8542889
38446755	38446778	19	-	27260156	RDES	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.3338431224906834	[553]	[473,459,420,685]	-5	hSpCas9	negative selection	8542890
38446688	38446711	19	+	27260156	RDES	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.2307755456019821	[724]	[716,609,791,709]	-4	hSpCas9	negative selection	8542891
38446544	38446567	19	+	27260156	PC3	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.00913342962609448	[360]	[294,271,622,349]	0	hSpCas9	negative selection	8599886
38444624	38444647	19	-	27260156	PC3	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.23706716899068198	[438]	[360,576,930,356]	5	hSpCas9	negative selection	8599887
38444581	38444604	19	+	27260156	PC3	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.44516332649033374	[288]	[256,558,483,308]	8	hSpCas9	negative selection	8599888
38446489	38446512	19	+	27260156	PC3	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.16973373626310284	[1064]	[966,973,1833,1217]	4	hSpCas9	negative selection	8664140
38446755	38446778	19	-	27260156	PC3	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.03878063711627111	[553]	[480,396,795,537]	-1	hSpCas9	negative selection	8664141
38446688	38446711	19	+	27260156	PC3	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.09882752910326598	[724]	[446,734,1806,576]	2	hSpCas9	negative selection	8664142
38446544	38446567	19	+	27260156	PATU8988T	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	-0.1389334737941293	[360]	[363,367,265,270]	-2	hSpCas9	negative selection	8721137
38444624	38444647	19	-	27260156	PATU8988T	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.010267904101903313	[438]	[285,368,488,569]	0	hSpCas9	negative selection	8721138
38444581	38444604	19	+	27260156	PATU8988T	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.17705763137703512	[288]	[325,201,513,197]	3	hSpCas9	negative selection	8721139
38446489	38446512	19	+	27260156	PATU8988T	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	-0.20576346767615428	[1064]	[665,1060,855,1011]	-4	hSpCas9	negative selection	8785391
38446755	38446778	19	-	27260156	PATU8988T	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.8946086107391705	[553]	[205,203,313,430]	-8	hSpCas9	negative selection	8785392
38446688	38446711	19	+	27260156	PATU8988T	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.32876228729548507	[724]	[591,530,437,678]	-5	hSpCas9	negative selection	8785393
38446544	38446567	19	+	27260156	T47D	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	-0.0054670919307522325	[360]	[413,402,374,487]	0	hSpCas9	negative selection	8842388
38444624	38444647	19	-	27260156	T47D	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.0733700011322318	[438]	[546,449,615,545]	1	hSpCas9	negative selection	8842389
38444581	38444604	19	+	27260156	T47D	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.3345723574860333	[288]	[398,498,396,395]	7	hSpCas9	negative selection	8842390
38446489	38446512	19	+	27260156	T47D	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.08759081630341314	[1064]	[1478,1266,1312,1215]	1	hSpCas9	negative selection	8906642
38446755	38446778	19	-	27260156	T47D	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.08179815088713707	[553]	[625,551,563,705]	-2	hSpCas9	negative selection	8906643
38446688	38446711	19	+	27260156	T47D	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.043227894132609745	[724]	[1006,777,775,931]	0	hSpCas9	negative selection	8906644
38446544	38446567	19	+	27260156	SU8686	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	-0.09956083436523361	[360]	[354,240,425,321]	-2	hSpCas9	negative selection	8963639
38444624	38444647	19	-	27260156	SU8686	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.2300235961843367	[438]	[463,484,482,633]	4	hSpCas9	negative selection	8963640
38444581	38444604	19	+	27260156	SU8686	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.24843113399962635	[288]	[302,318,316,442]	4	hSpCas9	negative selection	8963641
38446489	38446512	19	+	27260156	SU8686	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.011135163367525402	[1064]	[904,893,1236,1294]	0	hSpCas9	negative selection	9027893
38446755	38446778	19	-	27260156	SU8686	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.01621271784135861	[553]	[480,425,574,741]	0	hSpCas9	negative selection	9027894
38446688	38446711	19	+	27260156	SU8686	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.014807188127772153	[724]	[589,625,813,862]	0	hSpCas9	negative selection	9027895
38446544	38446567	19	+	27260156	SKES1	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.0003659790269129881	[360]	[360,491,318,289]	0	hSpCas9	negative selection	9084890
38444624	38444647	19	-	27260156	SKES1	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.5557243259224589	[438]	[805,603,583,597]	9	hSpCas9	negative selection	9084891
38444581	38444604	19	+	27260156	SKES1	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.2670250468677058	[288]	[415,434,301,261]	5	hSpCas9	negative selection	9084892
38446489	38446512	19	+	27260156	SKES1	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.1568682478174761	[1064]	[1222,1623,1152,826]	3	hSpCas9	negative selection	9149144
38446755	38446778	19	-	27260156	SKES1	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	0.01859909714551103	[553]	[621,665,484,490]	0	hSpCas9	negative selection	9149145
38446688	38446711	19	+	27260156	SKES1	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.004875490280232486	[724]	[704,807,768,613]	0	hSpCas9	negative selection	9149146
38446544	38446567	19	+	27260156	TOV112D	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	-0.2302638420957483	[360]	[315,419,232,291]	-4	hSpCas9	negative selection	9206141
38444624	38444647	19	-	27260156	TOV112D	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.5366521118762445	[438]	[615,994,596,433]	8	hSpCas9	negative selection	9206142
38444581	38444604	19	+	27260156	TOV112D	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.2462517102201781	[288]	[337,510,346,220]	5	hSpCas9	negative selection	9206143
38446489	38446512	19	+	27260156	TOV112D	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.2495133609560547	[1064]	[1432,1523,1213,983]	5	hSpCas9	negative selection	9270395
38446755	38446778	19	-	27260156	TOV112D	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.22573016862679665	[553]	[627,617,317,383]	-4	hSpCas9	negative selection	9270396
38446688	38446711	19	+	27260156	TOV112D	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.32277684050482114	[724]	[434,636,673,576]	-6	hSpCas9	negative selection	9270397
38446544	38446567	19	+	27260156	TC71	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.12708391301490457	[360]	[385,396,405,507]	3	hSpCas9	negative selection	9327392
38444624	38444647	19	-	27260156	TC71	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.28236723748866743	[438]	[637,591,532,522]	7	hSpCas9	negative selection	9327393
38444581	38444604	19	+	27260156	TC71	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.4021571416389149	[288]	[383,323,412,523]	8	hSpCas9	negative selection	9327394
38446489	38446512	19	+	27260156	TC71	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.08620645650450975	[1064]	[1383,1164,1223,1060]	2	hSpCas9	negative selection	9391646
38446755	38446778	19	-	27260156	TC71	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	-0.021679832351464645	[553]	[523,502,532,795]	0	hSpCas9	negative selection	9391647
38446688	38446711	19	+	27260156	TC71	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	0.1974289419149372	[724]	[836,944,808,982]	5	hSpCas9	negative selection	9391648
38446544	38446567	19	+	27260156	TC32	viability	CTGACAGTGATGACCAGCGCAGG	RYR1	ENSG00000196218	0.02318684537833854	[360]	[356,198,520,367]	0	hSpCas9	negative selection	9448643
38444624	38444647	19	-	27260156	TC32	viability	GTTCCATAGTGTCTGCATGAAGG	RYR1	ENSG00000196218	0.4925332023592283	[438]	[656,480,717,473]	8	hSpCas9	negative selection	9448644
38444581	38444604	19	+	27260156	TC32	viability	CAGCACCTGTCGACCGCCAGTGG	RYR1	ENSG00000196218	0.23729646117259495	[288]	[377,157,393,403]	4	hSpCas9	negative selection	9448645
38446489	38446512	19	+	27260156	TC32	viability	CACGTCCTCCGCCTCTTTCATGG	RYR1	ENSG00000196218	0.2393299384508445	[1064]	[1292,801,1402,1332]	4	hSpCas9	negative selection	9512897
38446755	38446778	19	-	27260156	TC32	viability	CCGCCCTACCTGATTCTCAGTGG	RYR1	ENSG00000196218	0.11598125418518099	[553]	[494,405,777,655]	2	hSpCas9	negative selection	9512898
38446688	38446711	19	+	27260156	TC32	viability	CCCCAGACTTGTCTACTATGAGG	RYR1	ENSG00000196218	-0.17884925631209286	[724]	[479,553,605,773]	-3	hSpCas9	negative selection	9512899
38433835	38433858	19	+	27869803	HPAFII	viability after 27 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	1.2233681826510983	[160]	[345,73,NaN]	8	hSpCas9	negative selection	9567577
38440843	38440866	19	+	27869803	HPAFII	viability after 27 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-0.5448942017371927	[249]	[196,0,NaN]	-4	hSpCas9	negative selection	9567578
38442395	38442418	19	-	27869803	HPAFII	viability after 27 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	0.6040611687671344	[700]	[737,411,NaN]	5	hSpCas9	negative selection	9567579
38443611	38443634	19	+	27869803	HPAFII	viability after 27 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	0.05558297496180398	[485]	[378,170,NaN]	0	hSpCas9	negative selection	9567580
38443775	38443798	19	+	27869803	HPAFII	viability after 27 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	-0.4026534911624263	[482]	[262,132,NaN]	-3	hSpCas9	negative selection	9567581
38444654	38444677	19	-	27869803	HPAFII	viability after 27 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.20804079001727166	[196]	[93,140,NaN]	1	hSpCas9	negative selection	9567582
38433835	38433858	19	+	27869803	HPAFII	viability after 15 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	0.47653788161129246	[160]	[479,91,NaN]	5	hSpCas9	negative selection	9650026
38440843	38440866	19	+	27869803	HPAFII	viability after 15 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-1.3275056771556837	[249]	[193,52,NaN]	-8	hSpCas9	negative selection	9650027
38442395	38442418	19	-	27869803	HPAFII	viability after 15 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	0.04644367484016754	[700]	[954,667,NaN]	0	hSpCas9	negative selection	9650028
38443611	38443634	19	+	27869803	HPAFII	viability after 15 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	-0.322562314749404	[485]	[466,386,NaN]	-4	hSpCas9	negative selection	9650029
38443775	38443798	19	+	27869803	HPAFII	viability after 15 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	-0.523320962777291	[482]	[391,341,NaN]	-5	hSpCas9	negative selection	9650030
38444654	38444677	19	-	27869803	HPAFII	viability after 15 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.16656230117628437	[196]	[228,242,NaN]	2	hSpCas9	negative selection	9650031
38433835	38433858	19	+	27869803	ASPC1	viability after 36 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	-0.36302613617008295	[494]	[421,0,36]	-4	hSpCas9	negative selection	9732475
38440843	38440866	19	+	27869803	ASPC1	viability after 36 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	0.6409334246450888	[592]	[464,184,328]	6	hSpCas9	negative selection	9732476
38442395	38442418	19	-	27869803	ASPC1	viability after 36 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	-0.19543514420967578	[1622]	[699,395,423]	-2	hSpCas9	negative selection	9732477
38443611	38443634	19	+	27869803	ASPC1	viability after 36 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	1.4982207881429876	[801]	[1457,691,392]	9	hSpCas9	negative selection	9732478
38443775	38443798	19	+	27869803	ASPC1	viability after 36 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	0.5311562248779446	[972]	[422,669,390]	5	hSpCas9	negative selection	9732479
38444654	38444677	19	-	27869803	ASPC1	viability after 36 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.00025465987968265047	[404]	[150,157,119]	0	hSpCas9	negative selection	9732480
38433835	38433858	19	+	27869803	PATU8988S	viability after 35 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	-0.16982705884715005	[410]	[211,81,NaN]	-2	hSpCas9	negative selection	9814924
38440843	38440866	19	+	27869803	PATU8988S	viability after 35 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-0.8469567753321935	[524]	[140,93,NaN]	-7	hSpCas9	negative selection	9814925
38442395	38442418	19	-	27869803	PATU8988S	viability after 35 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	0.1398062344152149	[1276]	[630,501,NaN]	1	hSpCas9	negative selection	9814926
38443611	38443634	19	+	27869803	PATU8988S	viability after 35 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	-0.8259291641829335	[827]	[240,134,NaN]	-7	hSpCas9	negative selection	9814927
38443775	38443798	19	+	27869803	PATU8988S	viability after 35 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	-0.4645778812600544	[757]	[104,337,NaN]	-5	hSpCas9	negative selection	9814928
38444654	38444677	19	-	27869803	PATU8988S	viability after 35 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.4760471288189367	[297]	[139,193,NaN]	5	hSpCas9	negative selection	9814929
38433835	38433858	19	+	27869803	PATU8988S	viability after 31 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	-0.19302318325608153	[410]	[145,139,NaN]	-2	hSpCas9	negative selection	9897373
38440843	38440866	19	+	27869803	PATU8988S	viability after 31 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-0.44559898060446085	[524]	[125,188,NaN]	-5	hSpCas9	negative selection	9897374
38442395	38442418	19	-	27869803	PATU8988S	viability after 31 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	0.1503151269950742	[1276]	[521,619,NaN]	1	hSpCas9	negative selection	9897375
38443611	38443634	19	+	27869803	PATU8988S	viability after 31 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	-0.1902614431655812	[827]	[324,243,NaN]	-2	hSpCas9	negative selection	9897376
38443775	38443798	19	+	27869803	PATU8988S	viability after 31 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	0.2161131365134754	[757]	[208,531,NaN]	2	hSpCas9	negative selection	9897377
38444654	38444677	19	-	27869803	PATU8988S	viability after 31 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.4843271711847851	[297]	[112,233,NaN]	6	hSpCas9	negative selection	9897378
38433835	38433858	19	+	27869803	HPAFII	viability after 35 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	1.3044911755246975	[160]	[245,150,NaN]	8	hSpCas9	negative selection	9979822
38440843	38440866	19	+	27869803	HPAFII	viability after 35 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-0.25755163075272036	[249]	[198,0,NaN]	-2	hSpCas9	negative selection	9979823
38442395	38442418	19	-	27869803	HPAFII	viability after 35 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	0.4224252218036395	[700]	[619,312,NaN]	2	hSpCas9	negative selection	9979824
38443611	38443634	19	+	27869803	HPAFII	viability after 35 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	-0.5145044814030063	[485]	[167,176,NaN]	-3	hSpCas9	negative selection	9979825
38443775	38443798	19	+	27869803	HPAFII	viability after 35 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	-0.4579612910185349	[482]	[201,150,NaN]	-3	hSpCas9	negative selection	9979826
38444654	38444677	19	-	27869803	HPAFII	viability after 35 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.7835471443220511	[196]	[102,248,NaN]	5	hSpCas9	negative selection	9979827
38433835	38433858	19	+	27869803	HPAFII	viability after 31 days	TGACGCAGAAGGCGAAGACGAGG	RYR1	ENSG00000196218	1.1381465335142955	[160]	[262,128,NaN]	8	hSpCas9	negative selection	10062271
38440843	38440866	19	+	27869803	HPAFII	viability after 31 days	GGAGCCCACTAGCAACGCGCAGG	RYR1	ENSG00000196218	-1.028376019200974	[249]	[130,0,NaN]	-6	hSpCas9	negative selection	10062272
38442395	38442418	19	-	27869803	HPAFII	viability after 31 days	CTGCAGGGCTCGCACAGACAGGG	RYR1	ENSG00000196218	0.43328949766224945	[700]	[714,330,NaN]	3	hSpCas9	negative selection	10062273
38443611	38443634	19	+	27869803	HPAFII	viability after 31 days	CCGGCATGCACACAGCCGCATGG	RYR1	ENSG00000196218	-0.3002784153755049	[485]	[187,257,NaN]	-2	hSpCas9	negative selection	10062274
38443775	38443798	19	+	27869803	HPAFII	viability after 31 days	GGACTGCAGGAGGACGCAACAGG	RYR1	ENSG00000196218	-0.7116339875042929	[482]	[165,164,NaN]	-5	hSpCas9	negative selection	10062275
38444654	38444677	19	-	27869803	HPAFII	viability after 31 days	CTCTTCGCAGCGGGAGCAGATGG	RYR1	ENSG00000196218	0.696688700860331	[196]	[82,283,NaN]	5	hSpCas9	negative selection	10062276
38442417	38442440	19	+	28162770	P31FUJ	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	-0.3366380153989186	[71]	[66]	-3	hSpCas9	negative selection	10229210
38440809	38440832	19	-	28162770	P31FUJ	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	-0.3748212092868066	[95]	[86]	-3	hSpCas9	negative selection	10229211
38448415	38448438	19	+	28162770	P31FUJ	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	0.1502451806200282	[170]	[222]	1	hSpCas9	negative selection	10229212
38448486	38448509	19	-	28162770	P31FUJ	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-2.4698414017152284	[32]	[6]	-8	hSpCas9	negative selection	10229213
38485992	38486015	19	-	28162770	P31FUJ	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	-0.05712252824625896	[138]	[156]	0	hSpCas9	negative selection	10229214
38496483	38496506	19	-	28162770	P31FUJ	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	-0.02129809922066661	[56]	[65]	0	hSpCas9	negative selection	10229215
38505358	38505381	19	-	28162770	P31FUJ	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	-0.15188220903081104	[207]	[219]	-1	hSpCas9	negative selection	10229216
38546480	38546503	19	+	28162770	P31FUJ	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-0.5791269536092082	[163]	[128]	-5	hSpCas9	negative selection	10229217
38440735	38440758	19	+	28162770	P31FUJ	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	0.4540399103259912	[409]	[659]	5	hSpCas9	negative selection	10229218
38442417	38442440	19	+	28162770	TF1	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	NaN	[NaN]	[1]	1	hSpCas9	negative selection	10398576
38440809	38440832	19	-	28162770	TF1	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10398577
38448415	38448438	19	+	28162770	TF1	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	NaN	[NaN]	[96]	1	hSpCas9	negative selection	10398578
38448486	38448509	19	-	28162770	TF1	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10398579
38485992	38486015	19	-	28162770	TF1	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	NaN	[NaN]	[87]	1	hSpCas9	negative selection	10398580
38496483	38496506	19	-	28162770	TF1	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	NaN	[NaN]	[1]	1	hSpCas9	negative selection	10398581
38505358	38505381	19	-	28162770	TF1	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	NaN	[NaN]	[106]	1	hSpCas9	negative selection	10398582
38546480	38546503	19	+	28162770	TF1	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	NaN	[NaN]	[24]	1	hSpCas9	negative selection	10398583
38440735	38440758	19	+	28162770	TF1	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	NaN	[NaN]	[65]	1	hSpCas9	negative selection	10398584
38442417	38442440	19	+	28162770	SKM1	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	0.4805610719984259	[14]	[36]	4	hSpCas9	negative selection	10567942
38440809	38440832	19	-	28162770	SKM1	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	0.42085482587415796	[29]	[70]	4	hSpCas9	negative selection	10567943
38448415	38448438	19	+	28162770	SKM1	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	-1.0263601965281919	[52]	[45]	-6	hSpCas9	negative selection	10567944
38448486	38448509	19	-	28162770	SKM1	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-2.8220016980220053	[15]	[3]	-9	hSpCas9	negative selection	10567945
38485992	38486015	19	-	28162770	SKM1	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	-0.07280980152253991	[46]	[78]	0	hSpCas9	negative selection	10567946
38496483	38496506	19	-	28162770	SKM1	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	0.34792330342030686	[23]	[53]	3	hSpCas9	negative selection	10567947
38505358	38505381	19	-	28162770	SKM1	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	-0.21534412620153032	[43]	[66]	-2	hSpCas9	negative selection	10567948
38546480	38546503	19	+	28162770	SKM1	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-1.3215727075125172	[40]	[28]	-7	hSpCas9	negative selection	10567949
38440735	38440758	19	+	28162770	SKM1	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	-0.1699250014423123	[69]	[109]	-1	hSpCas9	negative selection	10567950
38442417	38442440	19	+	28162770	SKM1	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	0.4805610719984259	[14]	[36]	4	hSpCas9	negative selection	10737308
38440809	38440832	19	-	28162770	SKM1	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	0.42085482587415796	[29]	[70]	4	hSpCas9	negative selection	10737309
38448415	38448438	19	+	28162770	SKM1	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	-1.0263601965281919	[52]	[45]	-6	hSpCas9	negative selection	10737310
38448486	38448509	19	-	28162770	SKM1	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-2.8220016980220053	[15]	[3]	-9	hSpCas9	negative selection	10737311
38485992	38486015	19	-	28162770	SKM1	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	-0.07280980152253991	[46]	[78]	0	hSpCas9	negative selection	10737312
38496483	38496506	19	-	28162770	SKM1	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	0.34792330342030686	[23]	[53]	3	hSpCas9	negative selection	10737313
38505358	38505381	19	-	28162770	SKM1	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	-0.21534412620153032	[43]	[66]	-2	hSpCas9	negative selection	10737314
38546480	38546503	19	+	28162770	SKM1	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-1.3215727075125172	[40]	[28]	-7	hSpCas9	negative selection	10737315
38440735	38440758	19	+	28162770	SKM1	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	-0.1699250014423123	[69]	[109]	-1	hSpCas9	negative selection	10737316
38442417	38442440	19	+	28162770	PL21	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	-1.7067509811191983	[59]	[7]	-8	hSpCas9	negative selection	10906674
38440809	38440832	19	-	28162770	PL21	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	-1.384822886231836	[77]	[12]	-7	hSpCas9	negative selection	10906675
38448415	38448438	19	+	28162770	PL21	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	-0.23010029143319416	[158]	[58]	-2	hSpCas9	negative selection	10906676
38448486	38448509	19	-	28162770	PL21	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-2.5724498894076078	[40]	[2]	-9	hSpCas9	negative selection	10906677
38485992	38486015	19	-	28162770	PL21	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	0.525101769466316	[189]	[118]	4	hSpCas9	negative selection	10906678
38496483	38496506	19	-	28162770	PL21	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	-0.0799683047034152	[67]	[27]	0	hSpCas9	negative selection	10906679
38505358	38505381	19	-	28162770	PL21	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	-0.7118042088454837	[142]	[37]	-5	hSpCas9	negative selection	10906680
38546480	38546503	19	+	28162770	PL21	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-0.7532102922118584	[212]	[54]	-5	hSpCas9	negative selection	10906681
38440735	38440758	19	+	28162770	PL21	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	0.2819779065457814	[256]	[135]	2	hSpCas9	negative selection	10906682
38442417	38442440	19	+	28162770	P31FUJ	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	-0.3366380153989186	[71]	[66]	-3	hSpCas9	negative selection	11076040
38440809	38440832	19	-	28162770	P31FUJ	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	-0.3748212092868066	[95]	[86]	-3	hSpCas9	negative selection	11076041
38448415	38448438	19	+	28162770	P31FUJ	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	0.1502451806200282	[170]	[222]	1	hSpCas9	negative selection	11076042
38448486	38448509	19	-	28162770	P31FUJ	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-2.4698414017152284	[32]	[6]	-8	hSpCas9	negative selection	11076043
38485992	38486015	19	-	28162770	P31FUJ	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	-0.05712252824625896	[138]	[156]	0	hSpCas9	negative selection	11076044
38496483	38496506	19	-	28162770	P31FUJ	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	-0.02129809922066661	[56]	[65]	0	hSpCas9	negative selection	11076045
38505358	38505381	19	-	28162770	P31FUJ	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	-0.15188220903081104	[207]	[219]	-1	hSpCas9	negative selection	11076046
38546480	38546503	19	+	28162770	P31FUJ	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-0.5791269536092082	[163]	[128]	-5	hSpCas9	negative selection	11076047
38440735	38440758	19	+	28162770	P31FUJ	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	0.4540399103259912	[409]	[659]	5	hSpCas9	negative selection	11076048
38442417	38442440	19	+	28162770	OCIAML5	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	0.7051509393742548	[34]	[102]	6	hSpCas9	negative selection	11245406
38440809	38440832	19	-	28162770	OCIAML5	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	0.3262706703945155	[37]	[85]	2	hSpCas9	negative selection	11245407
38448415	38448438	19	+	28162770	OCIAML5	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	0.5438621054671424	[75]	[199]	5	hSpCas9	negative selection	11245408
38448486	38448509	19	-	28162770	OCIAML5	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-2.989570094613932	[21]	[4]	-8	hSpCas9	negative selection	11245409
38485992	38486015	19	-	28162770	OCIAML5	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	-0.714563047114062	[109]	[120]	-5	hSpCas9	negative selection	11245410
38496483	38496506	19	-	28162770	OCIAML5	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	0.3918590120220924	[37]	[89]	3	hSpCas9	negative selection	11245411
38505358	38505381	19	-	28162770	OCIAML5	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	0.4564824942221656	[64]	[160]	4	hSpCas9	negative selection	11245412
38546480	38546503	19	+	28162770	OCIAML5	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-0.4010823751787618	[108]	[148]	-3	hSpCas9	negative selection	11245413
38440735	38440758	19	+	28162770	OCIAML5	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	0.6288510477845222	[205]	[574]	5	hSpCas9	negative selection	11245414
38442417	38442440	19	+	28162770	EOL1	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	-0.2532393476447481	[137]	[60]	-2	hSpCas9	negative selection	11414772
38440809	38440832	19	-	28162770	EOL1	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	1.6702305828378496	[98]	[165]	9	hSpCas9	negative selection	11414773
38448415	38448438	19	+	28162770	EOL1	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	0.24861161080188793	[269]	[168]	2	hSpCas9	negative selection	11414774
38448486	38448509	19	-	28162770	EOL1	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-3.4504916597763904	[82]	[3]	-9	hSpCas9	negative selection	11414775
38485992	38486015	19	-	28162770	EOL1	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	-0.9050807795007221	[358]	[100]	-6	hSpCas9	negative selection	11414776
38496483	38496506	19	-	28162770	EOL1	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	0.0665667764429625	[115]	[63]	0	hSpCas9	negative selection	11414777
38505358	38505381	19	-	28162770	EOL1	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	0.9774966515194936	[213]	[221]	8	hSpCas9	negative selection	11414778
38546480	38546503	19	+	28162770	EOL1	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-1.2849055940584153	[184]	[39]	-7	hSpCas9	negative selection	11414779
38440735	38440758	19	+	28162770	EOL1	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	1.443921930664114	[359]	[515]	9	hSpCas9	negative selection	11414780
38442417	38442440	19	+	28162770	MOLM13	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	0.493200470073766	[112]	[114]	3	hSpCas9	negative selection	11584138
38440809	38440832	19	-	28162770	MOLM13	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	-0.6316462920063355	[104]	[48]	-4	hSpCas9	negative selection	11584139
38448415	38448438	19	+	28162770	MOLM13	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	-0.4276413518993919	[252]	[135]	-3	hSpCas9	negative selection	11584140
38448486	38448509	19	-	28162770	MOLM13	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-2.934209062026767	[73]	[6]	-8	hSpCas9	negative selection	11584141
38485992	38486015	19	-	28162770	MOLM13	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	-0.6165609402547326	[298]	[140]	-4	hSpCas9	negative selection	11584142
38496483	38496506	19	-	28162770	MOLM13	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	0.8901223822276265	[49]	[66]	6	hSpCas9	negative selection	11584143
38505358	38505381	19	-	28162770	MOLM13	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	0.4768225063145867	[160]	[161]	3	hSpCas9	negative selection	11584144
38546480	38546503	19	+	28162770	MOLM13	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-1.754503039791869	[209]	[44]	-7	hSpCas9	negative selection	11584145
38440735	38440758	19	+	28162770	MOLM13	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	0.3758137966461997	[371]	[348]	2	hSpCas9	negative selection	11584146
38442417	38442440	19	+	28162770	HEL	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	0.23180573105424973	[116]	[87]	2	hSpCas9	negative selection	11753504
38440809	38440832	19	-	28162770	HEL	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	-0.5571987385083952	[84]	[36]	-4	hSpCas9	negative selection	11753505
38448415	38448438	19	+	28162770	HEL	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	0.5614387298985088	[218]	[206]	5	hSpCas9	negative selection	11753506
38448486	38448509	19	-	28162770	HEL	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-1.153727773914511	[65]	[18]	-6	hSpCas9	negative selection	11753507
38485992	38486015	19	-	28162770	HEL	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	0.345606648960135	[273]	[222]	3	hSpCas9	negative selection	11753508
38496483	38496506	19	-	28162770	HEL	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	0.04007432954574175	[81]	[53]	0	hSpCas9	negative selection	11753509
38505358	38505381	19	-	28162770	HEL	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	-0.23861667150102406	[174]	[94]	-2	hSpCas9	negative selection	11753510
38546480	38546503	19	+	28162770	HEL	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-0.5444641608737908	[188]	[82]	-4	hSpCas9	negative selection	11753511
38440735	38440758	19	+	28162770	HEL	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	-0.09960995886275253	[357]	[213]	0	hSpCas9	negative selection	11753512
38442417	38442440	19	+	28162770	MV411	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	0.03170885972733828	[71]	[61]	0	hSpCas9	negative selection	11922870
38440809	38440832	19	-	28162770	MV411	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	-0.3375249499383808	[65]	[43]	-3	hSpCas9	negative selection	11922871
38448415	38448438	19	+	28162770	MV411	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	0.03403391267358216	[159]	[137]	0	hSpCas9	negative selection	11922872
38448486	38448509	19	-	28162770	MV411	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-1.822951777108623	[62]	[14]	-8	hSpCas9	negative selection	11922873
38485992	38486015	19	-	28162770	MV411	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	-1.519363272924194	[227]	[66]	-7	hSpCas9	negative selection	11922874
38496483	38496506	19	-	28162770	MV411	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	0.29474326556113184	[89]	[92]	2	hSpCas9	negative selection	11922875
38505358	38505381	19	-	28162770	MV411	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	0.04098667331534889	[104]	[90]	0	hSpCas9	negative selection	11922876
38546480	38546503	19	+	28162770	MV411	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-0.5074499513806933	[161]	[95]	-4	hSpCas9	negative selection	11922877
38440735	38440758	19	+	28162770	MV411	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	-0.1049809113263086	[262]	[205]	-1	hSpCas9	negative selection	11922878
38442417	38442440	19	+	28162770	MONOMAC1	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	0.05350661459104322	[57]	[68]	0	hSpCas9	negative selection	12092236
38440809	38440832	19	-	28162770	MONOMAC1	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	-1.0403113433721005	[60]	[33]	-7	hSpCas9	negative selection	12092237
38448415	38448438	19	+	28162770	MONOMAC1	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	0.9816690399249686	[90]	[205]	8	hSpCas9	negative selection	12092238
38448486	38448509	19	-	28162770	MONOMAC1	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-2.4449643605031395	[37]	[7]	-9	hSpCas9	negative selection	12092239
38485992	38486015	19	-	28162770	MONOMAC1	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	1.4041358808428612	[117]	[357]	9	hSpCas9	negative selection	12092240
38496483	38496506	19	-	28162770	MONOMAC1	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	-0.24010556895143975	[33]	[32]	-2	hSpCas9	negative selection	12092241
38505358	38505381	19	-	28162770	MONOMAC1	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	1.1360894544326727	[76]	[193]	8	hSpCas9	negative selection	12092242
38546480	38546503	19	+	28162770	MONOMAC1	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	-0.2111120322712764	[102]	[101]	-2	hSpCas9	negative selection	12092243
38440735	38440758	19	+	28162770	MONOMAC1	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	-0.04913815194724008	[175]	[194]	0	hSpCas9	negative selection	12092244
38442417	38442440	19	+	28162770	OCIAML2	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	-0.6524681482279743	[18]	[66]	-5	hSpCas9	negative selection	12261602
38440809	38440832	19	-	28162770	OCIAML2	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	0.42749056073862524	[10]	[81]	4	hSpCas9	negative selection	12261603
38448415	38448438	19	+	28162770	OCIAML2	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	0.630908201219901	[23]	[205]	6	hSpCas9	negative selection	12261604
38448486	38448509	19	-	28162770	OCIAML2	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-1.5637392296336428	[7]	[14]	-7	hSpCas9	negative selection	12261605
38485992	38486015	19	-	28162770	OCIAML2	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	-0.16629579036953704	[32]	[162]	-1	hSpCas9	negative selection	12261606
38496483	38496506	19	-	28162770	OCIAML2	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	0.2918708610311822	[13]	[94]	3	hSpCas9	negative selection	12261607
38505358	38505381	19	-	28162770	OCIAML2	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	0.07780679945388091	[19]	[116]	0	hSpCas9	negative selection	12261608
38546480	38546503	19	+	28162770	OCIAML2	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	0.11433267547899481	[38]	[233]	1	hSpCas9	negative selection	12261609
38440735	38440758	19	+	28162770	OCIAML2	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	1.2162122894982086	[40]	[527]	9	hSpCas9	negative selection	12261610
38442417	38442440	19	+	28162770	OCIAML3	viability	GGAGATGCTGGCTAACACGGTGG	RYR1	ENSG00000196218	0.11968817451919567	[24]	[81]	1	hSpCas9	negative selection	12430968
38440809	38440832	19	-	28162770	OCIAML3	viability	GCGGTTGCCGAAGCCCTCGGCGG	RYR1	ENSG00000196218	-0.41343539468234236	[14]	[33]	-3	hSpCas9	negative selection	12430969
38448415	38448438	19	+	28162770	OCIAML3	viability	GCAGTACCTAGCGCTCACCGAGG	RYR1	ENSG00000196218	0.5190550241624726	[45]	[198]	5	hSpCas9	negative selection	12430970
38448486	38448509	19	-	28162770	OCIAML3	viability	GGAGATGCGGAAGCAGAAGGAGG	RYR1	ENSG00000196218	-6.294447358465256	[25]	[0]	-9	hSpCas9	negative selection	12430971
38485992	38486015	19	-	28162770	OCIAML3	viability	GCAGAGCGGCCACGAAACAGGGG	RYR1	ENSG00000196218	0.18522368081905294	[36]	[126]	1	hSpCas9	negative selection	12430972
38496483	38496506	19	-	28162770	OCIAML3	viability	GGTGGTCAAACATGGAGCGCTGG	RYR1	ENSG00000196218	0.873118370103135	[16]	[93]	7	hSpCas9	negative selection	12430973
38505358	38505381	19	-	28162770	OCIAML3	viability	GTAGGGCCTCAGCATGGGGTGGG	RYR1	ENSG00000196218	0.4968457901269504	[49]	[212]	4	hSpCas9	negative selection	12430974
38546480	38546503	19	+	28162770	OCIAML3	viability	GGATCTGCAGAAGGACATGGTGG	RYR1	ENSG00000196218	0.3620490120882396	[24]	[96]	3	hSpCas9	negative selection	12430975
38440735	38440758	19	+	28162770	OCIAML3	viability	GGTTCCGCAGGACGATGAGGTGG	RYR1	ENSG00000196218	-0.1502212025637013	[117]	[320]	-1	hSpCas9	negative selection	12430976