Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 6263
• Symbol: RYR3
• Description: ryanodine receptor 3

DataSource: http://genomecrispr.dkfz.de/#!/results/RYR3

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
33603283	33603306	15	+	26472758	Jiyoye	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-5.084677714823801	[134]	[2]	-9	hSpCas9	negative selection	141543
33530586	33530609	15	+	26472758	Jiyoye	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	-1.7083018359140625	[103]	[23]	-8	hSpCas9	negative selection	141544
33662517	33662540	15	-	26472758	Jiyoye	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-5.251036101245922	[100]	[1]	-9	hSpCas9	negative selection	141545
33662834	33662857	15	+	26472758	Jiyoye	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	0.40717538150587274	[0]	[0]	3	hSpCas9	negative selection	141546
33700977	33701000	15	-	26472758	Jiyoye	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	1.1956712763121615	[43]	[75]	7	hSpCas9	negative selection	141547
33707025	33707048	15	-	26472758	Jiyoye	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	2.4346561179279806	[12]	[52]	9	hSpCas9	negative selection	141548
33821561	33821584	15	+	26472758	Jiyoye	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	0.6147708009142409	[83]	[96]	4	hSpCas9	negative selection	141549
33473469	33473492	15	+	26472758	Jiyoye	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	5.86660700014317	[0]	[43]	9	hSpCas9	negative selection	141550
33473517	33473540	15	+	26472758	Jiyoye	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	0.2939647710578824	[158]	[146]	2	hSpCas9	negative selection	141551
33503715	33503738	15	+	26472758	Jiyoye	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.7067356633647813	[103]	[127]	5	hSpCas9	negative selection	141552
33603283	33603306	15	+	26472758	KBM7	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-5.534868357457208	[1266,515]	[4,11]	-9	hSpCas9	negative selection	332661
33530586	33530609	15	+	26472758	KBM7	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	0.8029591268272578	[311,299]	[369,145]	8	hSpCas9	negative selection	332662
33662517	33662540	15	-	26472758	KBM7	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-3.112681613630131	[323,106]	[7,13]	-9	hSpCas9	negative selection	332663
33662834	33662857	15	+	26472758	KBM7	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	-0.5756948416083496	[20,39]	[0,17]	-5	hSpCas9	negative selection	332664
33700977	33701000	15	-	26472758	KBM7	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	0.5496464331617272	[181,164]	[196,49]	6	hSpCas9	negative selection	332665
33707025	33707048	15	-	26472758	KBM7	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	0.08815275436792552	[348,349]	[164,184]	0	hSpCas9	negative selection	332666
33821561	33821584	15	+	26472758	KBM7	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	0.20950482088486203	[554,526]	[213,366]	2	hSpCas9	negative selection	332667
33473469	33473492	15	+	26472758	KBM7	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	1.7386039317485802	[64,41]	[138,31]	9	hSpCas9	negative selection	332668
33473517	33473540	15	+	26472758	KBM7	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	0.4891353532199411	[459,532]	[402,267]	5	hSpCas9	negative selection	332669
33503715	33503738	15	+	26472758	KBM7	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.4714514329476527	[828,674]	[279,672]	5	hSpCas9	negative selection	332670
33603283	33603306	15	+	26472758	Raji	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-3.944278584448893	[397]	[5]	-9	hSpCas9	negative selection	523779
33530586	33530609	15	+	26472758	Raji	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	0.6063222922613885	[166]	[58]	6	hSpCas9	negative selection	523780
33662517	33662540	15	-	26472758	Raji	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-3.507326308741609	[97]	[1]	-9	hSpCas9	negative selection	523781
33662834	33662857	15	+	26472758	Raji	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	-2.5364726544011256	[24]	[0]	-9	hSpCas9	negative selection	523782
33700977	33701000	15	-	26472758	Raji	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	0.5895352305109807	[62]	[21]	5	hSpCas9	negative selection	523783
33707025	33707048	15	-	26472758	Raji	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	0.2879557810154202	[119]	[33]	2	hSpCas9	negative selection	523784
33821561	33821584	15	+	26472758	Raji	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	0.557549258056045	[283]	[96]	5	hSpCas9	negative selection	523785
33473469	33473492	15	+	26472758	Raji	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	-0.8926164646264005	[95]	[11]	-6	hSpCas9	negative selection	523786
33473517	33473540	15	+	26472758	Raji	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	-1.0349951391830503	[414]	[46]	-6	hSpCas9	negative selection	523787
33503715	33503738	15	+	26472758	Raji	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.006856659419634981	[415]	[96]	0	hSpCas9	negative selection	523788
33603283	33603306	15	+	26472758	K562	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-5.473257695399949	[841]	[15]	-9	hSpCas9	negative selection	714897
33530586	33530609	15	+	26472758	K562	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	1.05538490327643	[227]	[399]	8	hSpCas9	negative selection	714898
33662517	33662540	15	-	26472758	K562	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-7.139285564807604	[166]	[0]	-9	hSpCas9	negative selection	714899
33662834	33662857	15	+	26472758	K562	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	-0.7369655941662066	[76]	[38]	-4	hSpCas9	negative selection	714900
33700977	33701000	15	-	26472758	K562	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	1.51959856336233	[68]	[166]	9	hSpCas9	negative selection	714901
33707025	33707048	15	-	26472758	K562	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	-0.7354033903959227	[354]	[179]	-4	hSpCas9	negative selection	714902
33821561	33821584	15	+	26472758	K562	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	1.2444187276664471	[390]	[781]	9	hSpCas9	negative selection	714903
33473469	33473492	15	+	26472758	K562	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.16977992677369103	[118]	[112]	1	hSpCas9	negative selection	714904
33473517	33473540	15	+	26472758	K562	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	-0.0031488768215764407	[500]	[421]	0	hSpCas9	negative selection	714905
33503715	33503738	15	+	26472758	K562	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.2847616150256036	[669]	[688]	2	hSpCas9	negative selection	714906
33311036	33311059	15	+	26627737	DLD1	viability	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.9382421171853476	[582]	[427,394,242]	8	hSpCas9	negative selection	790227
33473469	33473492	15	+	26627737	DLD1	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.7220835250535249	[136]	[94,57,59]	7	hSpCas9	negative selection	790228
33503697	33503720	15	+	26627737	DLD1	viability	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.0989324714833979	[1262]	[414,524,344]	1	hSpCas9	negative selection	790229
33530617	33530640	15	-	26627737	DLD1	viability	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.4513695349190705	[1135]	[426,503,520]	4	hSpCas9	negative selection	790230
33539356	33539379	15	-	26627737	DLD1	viability	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.8793474783275845	[402]	[207,341,160]	8	hSpCas9	negative selection	790231
33540869	33540892	15	+	26627737	DLD1	viability	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.5358832684896625	[525]	[139,400,188]	5	hSpCas9	negative selection	790232
33311036	33311059	15	+	26627737	GBM cells	viability after 5 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.11636724641058371	[417]	[230,254]	1	hSpCas9	negative selection	872542
33473469	33473492	15	+	26627737	GBM cells	viability after 5 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.22084196977304782	[123]	[86,67]	3	hSpCas9	negative selection	872543
33503697	33503720	15	+	26627737	GBM cells	viability after 5 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	-0.0887553232035947	[698]	[371,332]	-1	hSpCas9	negative selection	872544
33530617	33530640	15	-	26627737	GBM cells	viability after 5 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.36110622676133186	[616]	[432,416]	5	hSpCas9	negative selection	872545
33539356	33539379	15	-	26627737	GBM cells	viability after 5 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.6422772402500425	[269]	[232,218]	8	hSpCas9	negative selection	872546
33540869	33540892	15	+	26627737	GBM cells	viability after 5 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.07523664752614867	[399]	[197,253]	1	hSpCas9	negative selection	872547
33311036	33311059	15	+	26627737	GBM cells	viability after 13 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.19323056950876516	[417]	[239,274]	2	hSpCas9	negative selection	954857
33473469	33473492	15	+	26627737	GBM cells	viability after 13 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.4164558461480127	[123]	[91,87]	5	hSpCas9	negative selection	954858
33503697	33503720	15	+	26627737	GBM cells	viability after 13 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.09111344489121098	[698]	[446,368]	1	hSpCas9	negative selection	954859
33530617	33530640	15	-	26627737	GBM cells	viability after 13 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.15970071162962962	[616]	[427,329]	2	hSpCas9	negative selection	954860
33539356	33539379	15	-	26627737	GBM cells	viability after 13 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.32636829462146233	[269]	[170,193]	4	hSpCas9	negative selection	954861
33540869	33540892	15	+	26627737	GBM cells	viability after 13 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.26102269114166454	[399]	[269,251]	3	hSpCas9	negative selection	954862
33311036	33311059	15	+	26627737	GBM cells	viability after 21 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.49455177278857376	[417]	[332,307]	5	hSpCas9	negative selection	1037172
33473469	33473492	15	+	26627737	GBM cells	viability after 21 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.1821670332010582	[123]	[77,74]	2	hSpCas9	negative selection	1037173
33503697	33503720	15	+	26627737	GBM cells	viability after 21 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.23112169824910667	[698]	[451,439]	2	hSpCas9	negative selection	1037174
33530617	33530640	15	-	26627737	GBM cells	viability after 21 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.4728139070520967	[616]	[483,447]	5	hSpCas9	negative selection	1037175
33539356	33539379	15	-	26627737	GBM cells	viability after 21 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.4965948694164326	[269]	[207,205]	5	hSpCas9	negative selection	1037176
33540869	33540892	15	+	26627737	GBM cells	viability after 21 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.5532368609660083	[399]	[356,283]	5	hSpCas9	negative selection	1037177
33311036	33311059	15	+	26627737	RPE1	viability after 9 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.49567374291616006	[1322]	[521,663]	3	hSpCas9	negative selection	1119487
33473469	33473492	15	+	26627737	RPE1	viability after 9 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	1.6498573955772367	[563]	[378,779]	8	hSpCas9	negative selection	1119488
33503697	33503720	15	+	26627737	RPE1	viability after 9 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.1991374710678553	[2177]	[522,1117]	1	hSpCas9	negative selection	1119489
33530617	33530640	15	-	26627737	RPE1	viability after 9 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	1.0659140836369878	[1218]	[832,754]	6	hSpCas9	negative selection	1119490
33539356	33539379	15	-	26627737	RPE1	viability after 9 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	1.0014328417765352	[605]	[381,376]	6	hSpCas9	negative selection	1119491
33540869	33540892	15	+	26627737	RPE1	viability after 9 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	1.2095458141016675	[860]	[470,819]	7	hSpCas9	negative selection	1119492
33311036	33311059	15	+	26627737	RPE1	viability after 12 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.3043094827459797	[1322]	[418,459]	2	hSpCas9	negative selection	1201802
33473469	33473492	15	+	26627737	RPE1	viability after 12 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	1.1471589648268048	[563]	[219,457]	7	hSpCas9	negative selection	1201803
33503697	33503720	15	+	26627737	RPE1	viability after 12 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.3619120246338683	[2177]	[751,751]	2	hSpCas9	negative selection	1201804
33530617	33530640	15	-	26627737	RPE1	viability after 12 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	1.1779587333587593	[1218]	[655,830]	7	hSpCas9	negative selection	1201805
33539356	33539379	15	-	26627737	RPE1	viability after 12 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	1.1232186219917277	[605]	[393,312]	6	hSpCas9	negative selection	1201806
33540869	33540892	15	+	26627737	RPE1	viability after 12 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.9319980228499405	[860]	[350,536]	6	hSpCas9	negative selection	1201807
33311036	33311059	15	+	26627737	RPE1	viability after 15 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	-0.07279367624948929	[1322]	[308,400]	0	hSpCas9	negative selection	1284117
33473469	33473492	15	+	26627737	RPE1	viability after 15 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.9930878462928634	[563]	[285,347]	6	hSpCas9	negative selection	1284118
33503697	33503720	15	+	26627737	RPE1	viability after 15 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.35510772096638776	[2177]	[756,817]	2	hSpCas9	negative selection	1284119
33530617	33530640	15	-	26627737	RPE1	viability after 15 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	1.2414993066955864	[1218]	[796,832]	7	hSpCas9	negative selection	1284120
33539356	33539379	15	-	26627737	RPE1	viability after 15 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	1.205101571426028	[605]	[466,325]	7	hSpCas9	negative selection	1284121
33540869	33540892	15	+	26627737	RPE1	viability after 15 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.7539127709908908	[860]	[397,422]	4	hSpCas9	negative selection	1284122
33311036	33311059	15	+	26627737	RPE1	viability after 18 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	-0.10332531136046486	[1322]	[371,289]	0	hSpCas9	negative selection	1366432
33473469	33473492	15	+	26627737	RPE1	viability after 18 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.882960751365756	[563]	[227,336]	5	hSpCas9	negative selection	1366433
33503697	33503720	15	+	26627737	RPE1	viability after 18 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.4877870852700066	[2177]	[728,925]	3	hSpCas9	negative selection	1366434
33530617	33530640	15	-	26627737	RPE1	viability after 18 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.877541174656754	[1218]	[411,809]	5	hSpCas9	negative selection	1366435
33539356	33539379	15	-	26627737	RPE1	viability after 18 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	1.1983710723337913	[605]	[412,334]	6	hSpCas9	negative selection	1366436
33540869	33540892	15	+	26627737	RPE1	viability after 18 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	1.2229063078614426	[860]	[581,499]	7	hSpCas9	negative selection	1366437
33311036	33311059	15	+	26627737	HeLa	viability after 8 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	-0.4139364858491471	[976]	[376,258,332]	-4	hSpCas9	negative selection	1448747
33473469	33473492	15	+	26627737	HeLa	viability after 8 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.1466926894816596	[314]	[248,125,104]	1	hSpCas9	negative selection	1448748
33503697	33503720	15	+	26627737	HeLa	viability after 8 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	-0.32957363250394334	[1240]	[484,455,364]	-3	hSpCas9	negative selection	1448749
33530617	33530640	15	-	26627737	HeLa	viability after 8 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.679119371015775	[611]	[483,516,299]	6	hSpCas9	negative selection	1448750
33539356	33539379	15	-	26627737	HeLa	viability after 8 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	-0.017633431020581087	[402]	[192,260,76]	0	hSpCas9	negative selection	1448751
33540869	33540892	15	+	26627737	HeLa	viability after 8 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	1.0746207737986386	[360]	[427,285,301]	7	hSpCas9	negative selection	1448752
33311036	33311059	15	+	26627737	HeLa	viability after 12 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	-0.5708260873868344	[976]	[401,160,267]	-5	hSpCas9	negative selection	1531062
33473469	33473492	15	+	26627737	HeLa	viability after 12 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.5460451255382658	[314]	[171,205,189]	4	hSpCas9	negative selection	1531063
33503697	33503720	15	+	26627737	HeLa	viability after 12 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	-0.3118447533970192	[1240]	[453,447,334]	-3	hSpCas9	negative selection	1531064
33530617	33530640	15	-	26627737	HeLa	viability after 12 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.590102338243407	[611]	[484,363,297]	5	hSpCas9	negative selection	1531065
33539356	33539379	15	-	26627737	HeLa	viability after 12 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.8926415770508807	[402]	[328,310,287]	7	hSpCas9	negative selection	1531066
33540869	33540892	15	+	26627737	HeLa	viability after 12 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.9278774210571642	[360]	[321,279,250]	7	hSpCas9	negative selection	1531067
33311036	33311059	15	+	26627737	HeLa	viability after 15 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	-0.06523244170189102	[976]	[524,288,319]	0	hSpCas9	negative selection	1613377
33473469	33473492	15	+	26627737	HeLa	viability after 15 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.81514090949997	[314]	[232,263,175]	6	hSpCas9	negative selection	1613378
33503697	33503720	15	+	26627737	HeLa	viability after 15 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.3377969174382649	[1240]	[846,557,496]	3	hSpCas9	negative selection	1613379
33530617	33530640	15	-	26627737	HeLa	viability after 15 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.6013652500125566	[611]	[398,316,420]	5	hSpCas9	negative selection	1613380
33539356	33539379	15	-	26627737	HeLa	viability after 15 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.2920751407482376	[402]	[129,230,245]	2	hSpCas9	negative selection	1613381
33540869	33540892	15	+	26627737	HeLa	viability after 15 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.8696044433832446	[360]	[212,424,159]	6	hSpCas9	negative selection	1613382
33311036	33311059	15	+	26627737	HeLa	viability after 18 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	-0.06698464011357252	[976]	[349,240,319]	0	hSpCas9	negative selection	1695692
33473469	33473492	15	+	26627737	HeLa	viability after 18 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.8249216776878552	[314]	[162,213,175]	6	hSpCas9	negative selection	1695693
33503697	33503720	15	+	26627737	HeLa	viability after 18 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.36182641258274395	[1240]	[581,470,496]	3	hSpCas9	negative selection	1695694
33530617	33530640	15	-	26627737	HeLa	viability after 18 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.6364438646199315	[611]	[286,260,420]	5	hSpCas9	negative selection	1695695
33539356	33539379	15	-	26627737	HeLa	viability after 18 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.2874713019237218	[402]	[86,189,245]	2	hSpCas9	negative selection	1695696
33540869	33540892	15	+	26627737	HeLa	viability after 18 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.8995503514960471	[360]	[140,367,159]	6	hSpCas9	negative selection	1695697
33311036	33311059	15	+	26627737	HCT116	viability after 6 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	-0.428001186447472	[1671]	[215,183]	-2	hSpCas9	negative selection	1778007
33473469	33473492	15	+	26627737	HCT116	viability after 6 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.10652666414897127	[542]	[127,71]	0	hSpCas9	negative selection	1778008
33503697	33503720	15	+	26627737	HCT116	viability after 6 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.27112607887061535	[1668]	[431,252]	1	hSpCas9	negative selection	1778009
33530617	33530640	15	-	26627737	HCT116	viability after 6 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	-0.6781351514615979	[1314]	[270,50]	-4	hSpCas9	negative selection	1778010
33539356	33539379	15	-	26627737	HCT116	viability after 6 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	-0.17306967616985133	[669]	[95,91]	-1	hSpCas9	negative selection	1778011
33540869	33540892	15	+	26627737	HCT116	viability after 6 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.4983433163592278	[592]	[141,125]	2	hSpCas9	negative selection	1778012
33311036	33311059	15	+	26627737	HCT116	viability after 8 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.6494488848795356	[505]	[363,448,496]	6	hSpCas9	negative selection	1860322
33473469	33473492	15	+	26627737	HCT116	viability after 8 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	-0.7083446691520425	[269]	[121,83,67]	-7	hSpCas9	negative selection	1860323
33503697	33503720	15	+	26627737	HCT116	viability after 8 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	-0.5210203607020092	[1287]	[549,459,474]	-6	hSpCas9	negative selection	1860324
33530617	33530640	15	-	26627737	HCT116	viability after 8 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.46776428980341955	[586]	[365,566,407]	5	hSpCas9	negative selection	1860325
33539356	33539379	15	-	26627737	HCT116	viability after 8 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.2588719107633705	[370]	[263,210,258]	3	hSpCas9	negative selection	1860326
33540869	33540892	15	+	26627737	HCT116	viability after 8 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.43528047653487123	[426]	[367,240,345]	4	hSpCas9	negative selection	1860327
33311036	33311059	15	+	26627737	HCT116	viability after 9 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	-0.525867625199301	[1671]	[356,272]	-4	hSpCas9	negative selection	1942637
33473469	33473492	15	+	26627737	HCT116	viability after 9 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	-0.3208295260540168	[542]	[38,176]	-2	hSpCas9	negative selection	1942638
33503697	33503720	15	+	26627737	HCT116	viability after 9 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	-0.020813376830228547	[1668]	[574,331]	0	hSpCas9	negative selection	1942639
33530617	33530640	15	-	26627737	HCT116	viability after 9 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.9328969818658301	[1314]	[523,785]	6	hSpCas9	negative selection	1942640
33539356	33539379	15	-	26627737	HCT116	viability after 9 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.7421908211002988	[669]	[210,368]	5	hSpCas9	negative selection	1942641
33540869	33540892	15	+	26627737	HCT116	viability after 9 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.07493673042460543	[592]	[144,183]	0	hSpCas9	negative selection	1942642
33311036	33311059	15	+	26627737	HCT116	viability after 12 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.5758839100501859	[505]	[513,363,299]	5	hSpCas9	negative selection	2024952
33473469	33473492	15	+	26627737	HCT116	viability after 12 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.11843090410977632	[269]	[92,258,117]	1	hSpCas9	negative selection	2024953
33503697	33503720	15	+	26627737	HCT116	viability after 12 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	-0.25381308679723014	[1287]	[618,627,452]	-3	hSpCas9	negative selection	2024954
33530617	33530640	15	-	26627737	HCT116	viability after 12 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.6038490884527019	[586]	[362,395,654]	5	hSpCas9	negative selection	2024955
33539356	33539379	15	-	26627737	HCT116	viability after 12 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	-0.23579875494649866	[370]	[172,162,159]	-2	hSpCas9	negative selection	2024956
33540869	33540892	15	+	26627737	HCT116	viability after 12 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.1803975534667558	[426]	[247,236,277]	2	hSpCas9	negative selection	2024957
33311036	33311059	15	+	26627737	HCT116	viability after 15 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.1734869611210521	[505]	[512,353,140]	1	hSpCas9	negative selection	2107267
33473469	33473492	15	+	26627737	HCT116	viability after 15 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	-0.40353634432354246	[269]	[137,164,51]	-4	hSpCas9	negative selection	2107268
33503697	33503720	15	+	26627737	HCT116	viability after 15 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	-0.257410463755138	[1287]	[603,494,753]	-3	hSpCas9	negative selection	2107269
33530617	33530640	15	-	26627737	HCT116	viability after 15 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.6181656267880025	[586]	[426,570,542]	5	hSpCas9	negative selection	2107270
33539356	33539379	15	-	26627737	HCT116	viability after 15 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.3075563587843377	[370]	[232,262,290]	3	hSpCas9	negative selection	2107271
33540869	33540892	15	+	26627737	HCT116	viability after 15 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.5836104375671576	[426]	[386,279,436]	5	hSpCas9	negative selection	2107272
33311036	33311059	15	+	26627737	HCT116	viability after 18 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.4303347477855485	[505]	[274,205,524]	3	hSpCas9	negative selection	2189582
33473469	33473492	15	+	26627737	HCT116	viability after 18 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	-0.2271486111942895	[269]	[117,104,111]	-2	hSpCas9	negative selection	2189583
33503697	33503720	15	+	26627737	HCT116	viability after 18 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	-0.0051600596583960545	[1287]	[609,610,641]	0	hSpCas9	negative selection	2189584
33530617	33530640	15	-	26627737	HCT116	viability after 18 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.7821046376467407	[586]	[416,525,519]	6	hSpCas9	negative selection	2189585
33539356	33539379	15	-	26627737	HCT116	viability after 18 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.5388666686305379	[370]	[201,290,287]	4	hSpCas9	negative selection	2189586
33540869	33540892	15	+	26627737	HCT116	viability after 18 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.29656360922509095	[426]	[204,218,342]	2	hSpCas9	negative selection	2189587
33325679	33325702	15	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGAAGGGGGAAGGGGGAAGGTGG	RYR3	ENSG00000198838	0.0223570948433367	[33,1]	[5,0]	0	dCas9-VP64	positive selection	2385963
33558175	33558198	15	-	25494202	A375	resistance to PLX-4720 (puromycin)	ATGGGTGCAGCACACCAACATAG	RYR3	ENSG00000198838	0.9169296655708145	[41,70]	[10,35]	4	dCas9-VP64	positive selection	2394323
33477730	33477753	15	-	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCGCCCGCCACCACGTCCGG	RYR3	ENSG00000198838	1.5618735705212097	[103,49]	[83,12]	6	dCas9-VP64	positive selection	2398367
33386881	33386904	15	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGAGTCTTGCTCTGTCGCCCGGG	RYR3	ENSG00000198838	1.2077108984929388	[2,0]	[0,0]	5	dCas9-VP64	positive selection	2399308
33349827	33349850	15	+	25494202	A375	resistance to PLX-4720 (puromycin)	GAGTGAGAATATGCGGTGTTTGG	RYR3	ENSG00000198838	-0.6843799399670565	[176,164]	[29,15]	-3	dCas9-VP64	positive selection	2432592
33325679	33325702	15	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGAAGGGGGAAGGGGGAAGGTGG	RYR3	ENSG00000198838	-0.7235323598164394	[9,32]	[2,4]	-7	dCas9-VP64	positive selection	2481218
33558175	33558198	15	-	25494202	A375	resistance to PLX-4720 (zeocin)	ATGGGTGCAGCACACCAACATAG	RYR3	ENSG00000198838	-0.10177986135090777	[222,128]	[45,60]	-1	dCas9-VP64	positive selection	2489578
33477730	33477753	15	-	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCGCCCGCCACCACGTCCGG	RYR3	ENSG00000198838	0.22222393386236713	[95,81]	[49,17]	1	dCas9-VP64	positive selection	2493622
33386881	33386904	15	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGAGTCTTGCTCTGTCGCCCGGG	RYR3	ENSG00000198838	-0.1122041493399547	[42,120]	[2,43]	-1	dCas9-VP64	positive selection	2494563
33349827	33349850	15	+	25494202	A375	resistance to PLX-4720 (zeocin)	GAGTGAGAATATGCGGTGTTTGG	RYR3	ENSG00000198838	1.7345023813454719	[65,109]	[27,158]	8	dCas9-VP64	positive selection	2527847
33473448	33473471	15	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CCACCATTCATAAGGAGCAGAGG	RYR3	ENSG00000198838	0.5019123161280745	[4,4]	[5,6]	8	hSpCas9	positive selection	3018419
33548192	33548215	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CTTCCATTACCTTATCCGAAGGG	RYR3	ENSG00000198838	0.12895715707830668	[4,4]	[4,3]	2	hSpCas9	positive selection	3018420
33726386	33726409	15	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCTCATCCAGACAGGAAAGGGGG	RYR3	ENSG00000198838	0.349599859897382	[3,3]	[4,3]	7	hSpCas9	positive selection	3018421
33634609	33634632	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTAATGCATATGGCACCAGACGG	RYR3	ENSG00000198838	0.40480691272855035	[3,3]	[4,3]	8	hSpCas9	positive selection	3018422
33473448	33473471	15	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CCACCATTCATAAGGAGCAGAGG	RYR3	ENSG00000198838	0.16156623899987554	[4,4]	[4,3]	3	hSpCas9	positive selection	3086277
33548192	33548215	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CTTCCATTACCTTATCCGAAGGG	RYR3	ENSG00000198838	-0.0909140505012152	[4,4]	[3,2]	-1	hSpCas9	positive selection	3086278
33726386	33726409	15	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCTCATCCAGACAGGAAAGGGGG	RYR3	ENSG00000198838	-0.07933949260500303	[3,3]	[2,1]	-1	hSpCas9	positive selection	3086279
33634609	33634632	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTAATGCATATGGCACCAGACGG	RYR3	ENSG00000198838	-0.5393741829499294	[3,3]	[3,0]	-7	hSpCas9	positive selection	3086280
33748491	33748514		-	24336571	A375	resistance to PLX after 7 days	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.47222716358206795	[27,23]	[18,17]	-9	hSpCas9	positive selection	3142334
33748248	33748271		-	24336571	A375	resistance to PLX after 7 days	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	-0.0445970979190643	[25,22]	[26,20]	-1	hSpCas9	positive selection	3142335
33748491	33748514		-	24336571	A375	resistance to PLX after 14 days	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.984279733175063	[20,21]	[4,3]	-9	hSpCas9	positive selection	3200127
33748248	33748271		-	24336571	A375	resistance to PLX after 14 days	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	-0.3242785288612232	[26,29]	[8,11]	-4	hSpCas9	positive selection	3200128
33748491	33748514		-	24336571	A375	viability after 7 days	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.7472205929208593	[15]	[27,23]	9	hSpCas9	negative selection	3257920
33748248	33748271		-	24336571	A375	viability after 7 days	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.5652301099894296	[16]	[25,22]	8	hSpCas9	negative selection	3257921
33748491	33748514		-	24336571	A375	viability after 14 days	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.48964978396189546	[15]	[20,21]	6	hSpCas9	negative selection	3315713
33748248	33748271		-	24336571	A375	viability after 14 days	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.7915254394125135	[16]	[26,29]	8	hSpCas9	negative selection	3315714
33749998	33750021	15	+	27383988	293T	resistance to West Nile virus (flavivirus)	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.537089654904271	[221,221]	[0,0]	-4	hSpCas9	positive selection	3391008
33748517	33748540	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.06750165256581787	[145,145]	[0,0]	0	hSpCas9	positive selection	3391009
33749969	33749992	15	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	0.5708256842626168	[102,102]	[0,0]	3	hSpCas9	positive selection	3391010
33473447	33473470	15	+	26780180	HT29	viability (Avana library 4 designs)	CCACCATTCATAAGGAGCAGAGG	RYR3	ENSG00000198838	-0.632395490751965	[]	[]	-8	hSpCas9	negative selection	3456817
33548192	33548215	15	-	26780180	HT29	viability (Avana library 4 designs)	CTTCCATTACCTTATCCGAAGGG	RYR3	ENSG00000198838	0.758432735273996	[]	[]	3	hSpCas9	negative selection	3456818
33726385	33726408	15	+	26780180	HT29	viability (Avana library 4 designs)	GCTCATCCAGACAGGAAAGGGGG	RYR3	ENSG00000198838	0.886950811244948	[]	[]	3	hSpCas9	negative selection	3456819
33634609	33634632	15	-	26780180	HT29	viability (Avana library 4 designs)	GTAATGCATATGGCACCAGACGG	RYR3	ENSG00000198838	0.615817532059672	[]	[]	2	hSpCas9	negative selection	3456820
33473447	33473470	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	CCACCATTCATAAGGAGCAGAGG	RYR3	ENSG00000198838	3.15339056784902	[]	[]	5	hSpCas9	negative selection	3555472
33634609	33634632	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTAATGCATATGGCACCAGACGG	RYR3	ENSG00000198838	2.48340910194155	[]	[]	3	hSpCas9	negative selection	3555473
33548192	33548215	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTTCCATTACCTTATCCGAAGGG	RYR3	ENSG00000198838	-2.40974651767417	[]	[]	-3	hSpCas9	negative selection	3555474
33726385	33726408	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCTCATCCAGACAGGAAAGGGGG	RYR3	ENSG00000198838	3.02088230131362	[]	[]	4	hSpCas9	negative selection	3555475
33728933	33728956	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	GATCCTTAATGCCATAAACGCGG	RYR3	ENSG00000198838	-4.46618134343291	[]	[]	-5	hSpCas9	negative selection	3555476
33649089	33649112	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	GATCCTGTCCAGCAAAGATGCGG	RYR3	ENSG00000198838	-0.419320031003102	[]	[]	0	hSpCas9	negative selection	3555477
33473447	33473470	15	+	26780180	A375	viability (Avana lentiGuide)	CCACCATTCATAAGGAGCAGAGG	RYR3	ENSG00000198838	-6.47108493502996	[]	[]	-9	hSpCas9	negative selection	3664131
33634609	33634632	15	-	26780180	A375	viability (Avana lentiGuide)	GTAATGCATATGGCACCAGACGG	RYR3	ENSG00000198838	-7.09729643850812	[]	[]	-9	hSpCas9	negative selection	3664132
33548192	33548215	15	-	26780180	A375	viability (Avana lentiGuide)	CTTCCATTACCTTATCCGAAGGG	RYR3	ENSG00000198838	-3.10154662626605	[]	[]	-5	hSpCas9	negative selection	3664133
33726385	33726408	15	+	26780180	A375	viability (Avana lentiGuide)	GCTCATCCAGACAGGAAAGGGGG	RYR3	ENSG00000198838	6.70342794990897	[]	[]	5	hSpCas9	negative selection	3664134
33728933	33728956	15	-	26780180	A375	viability (Avana lentiGuide)	GATCCTTAATGCCATAAACGCGG	RYR3	ENSG00000198838	0.745654145286556	[]	[]	0	hSpCas9	negative selection	3664135
33649089	33649112	15	-	26780180	A375	viability (Avana lentiGuide)	GATCCTGTCCAGCAAAGATGCGG	RYR3	ENSG00000198838	5.42809840174549	[]	[]	5	hSpCas9	negative selection	3664136
33473447	33473470	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCACCATTCATAAGGAGCAGAGG	RYR3	ENSG00000198838	0.10183929718909651	[5]	[6,5]	2	hSpCas9	positive selection	3772738
33634609	33634632	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTAATGCATATGGCACCAGACGG	RYR3	ENSG00000198838	0.011146420798241713	[5]	[6,4]	0	hSpCas9	positive selection	3772739
33548192	33548215	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTTCCATTACCTTATCCGAAGGG	RYR3	ENSG00000198838	-0.28018298208232467	[6]	[5,4]	-4	hSpCas9	positive selection	3772740
33726385	33726408	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTCATCCAGACAGGAAAGGGGG	RYR3	ENSG00000198838	0.29174829114316886	[4]	[4,5]	8	hSpCas9	positive selection	3772741
33728933	33728956	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GATCCTTAATGCCATAAACGCGG	RYR3	ENSG00000198838	-0.2878584559068063	[5]	[4,3]	-4	hSpCas9	positive selection	3772742
33649089	33649112	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GATCCTGTCCAGCAAAGATGCGG	RYR3	ENSG00000198838	0.04503268817290986	[4]	[4,4]	1	hSpCas9	positive selection	3772743
33473447	33473470	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCACCATTCATAAGGAGCAGAGG	RYR3	ENSG00000198838	0.24809382116037246	[6]	[6,5]	6	hSpCas9	positive selection	3881345
33634609	33634632	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTAATGCATATGGCACCAGACGG	RYR3	ENSG00000198838	-0.3807248288572496	[4]	[2,3]	-5	hSpCas9	positive selection	3881346
33548192	33548215	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTTCCATTACCTTATCCGAAGGG	RYR3	ENSG00000198838	-0.21192123972693183	[6]	[2,5]	-3	hSpCas9	positive selection	3881347
33726385	33726408	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTCATCCAGACAGGAAAGGGGG	RYR3	ENSG00000198838	-0.0008101063095397876	[5]	[4,3]	0	hSpCas9	positive selection	3881348
33728933	33728956	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GATCCTTAATGCCATAAACGCGG	RYR3	ENSG00000198838	0.037797281857580606	[5]	[3,5]	0	hSpCas9	positive selection	3881349
33649089	33649112	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GATCCTGTCCAGCAAAGATGCGG	RYR3	ENSG00000198838	-0.18990935043949542	[5]	[2,5]	-3	hSpCas9	positive selection	3881350
33749998	33750021	15	+	26780180	A375	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	1.05466262970446	[]	[]	5	hSpCas9	negative selection	3991377
33748199	33748222	15	+	26780180	A375	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.758821519935605	[]	[]	3	hSpCas9	negative selection	3991378
33748491	33748514	15	-	26780180	A375	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	1.24741714406788	[]	[]	6	hSpCas9	negative selection	3991379
33748517	33748540	15	-	26780180	A375	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.789329227971141	[]	[]	3	hSpCas9	negative selection	3991380
33748248	33748271	15	-	26780180	A375	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.688206909620082	[]	[]	2	hSpCas9	negative selection	3991381
33749969	33749992	15	+	26780180	A375	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	1.64448548219268	[]	[]	8	hSpCas9	negative selection	3991382
33749998	33750021	15	+	26780180	HT29	viability (GeCKOv2 library)	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.316250236232049	[]	[]	0	hSpCas9	negative selection	4099343
33748199	33748222	15	+	26780180	HT29	viability (GeCKOv2 library)	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.638120652717007	[]	[]	2	hSpCas9	negative selection	4099344
33748491	33748514	15	-	26780180	HT29	viability (GeCKOv2 library)	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	1.21858162369567	[]	[]	6	hSpCas9	negative selection	4099345
33748517	33748540	15	-	26780180	HT29	viability (GeCKOv2 library)	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	1.66172581102853	[]	[]	8	hSpCas9	negative selection	4099346
33748248	33748271	15	-	26780180	HT29	viability (GeCKOv2 library)	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.725817916854132	[]	[]	2	hSpCas9	negative selection	4099347
33749969	33749992	15	+	26780180	HT29	viability (GeCKOv2 library)	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	1.76919497329954	[]	[]	8	hSpCas9	negative selection	4099348
33748491	33748514	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.057627753100382054	[3]	[3,2]	1	hSpCas9	positive selection	4168061
33748248	33748271	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	-0.031707205458058774	[4]	[2,3]	0	hSpCas9	positive selection	4168062
33748491	33748514	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	1.3566333011549117	[3]	[1,4,4,3]	9	hSpCas9	positive selection	4232083
33748248	33748271	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.7718285147991193	[4]	[3,0,2,3]	5	hSpCas9	positive selection	4232084
33748491	33748514	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.19221365870148527	[2]	[1,0]	-4	hSpCas9	positive selection	4296157
33748248	33748271	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.030184086604871208	[1]	[1,1]	0	hSpCas9	positive selection	4296158
33748199	33748222	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	-0.03445131226641074	[2]	[2,1]	0	hSpCas9	positive selection	4296159
33749998	33750021	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.07302372576776225	[3]	[3,2]	1	hSpCas9	positive selection	4360411
33748517	33748540	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	-0.36139415891344984	[2]	[1,0]	-6	hSpCas9	positive selection	4360412
33749969	33749992	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.6323902975484367	[2]	[1,0]	-9	hSpCas9	positive selection	4360413
33586085	33586107	15	-	27760321	OCIAML3	viability	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	-0.16268720160441796	[657,550]	[378,474]	-2	hSpCas9	negative selection	4436522
33635761	33635783	15	+	27760321	OCIAML3	viability	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	-0.21601214451569753	[560,477]	[319,385]	-2	hSpCas9	negative selection	4436523
33636436	33636458	15	+	27760321	OCIAML3	viability	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	-0.3550048017381301	[297,234]	[190,123]	-4	hSpCas9	negative selection	4436524
33636524	33636546	15	-	27760321	OCIAML3	viability	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	0.3866757814146531	[702,610]	[660,681]	4	hSpCas9	negative selection	4436525
33652782	33652804	15	+	27760321	OCIAML3	viability	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	1.0780296643248377	[617,514]	[907,961]	9	hSpCas9	negative selection	4436526
33586085	33586107	15	-	27760321	OCIAML2	viability	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	0.2917517307798278	[657,550]	[540,668]	4	hSpCas9	negative selection	4519985
33635761	33635783	15	+	27760321	OCIAML2	viability	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	0.3125138201274009	[560,477]	[470,584]	4	hSpCas9	negative selection	4519986
33636436	33636458	15	+	27760321	OCIAML2	viability	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	0.10643783160014464	[297,234]	[183,291]	1	hSpCas9	negative selection	4519987
33636524	33636546	15	-	27760321	OCIAML2	viability	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	0.6237163191510564	[702,610]	[765,883]	8	hSpCas9	negative selection	4519988
33652782	33652804	15	+	27760321	OCIAML2	viability	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	0.4285553095454592	[617,514]	[520,736]	6	hSpCas9	negative selection	4519989
33586085	33586107	15	-	27760321	MV411	viability	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	-1.350451063944623	[657,550]	[176,123]	-7	hSpCas9	negative selection	4603448
33635761	33635783	15	+	27760321	MV411	viability	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	0.16448587260217848	[560,477]	[95,813]	1	hSpCas9	negative selection	4603449
33636436	33636458	15	+	27760321	MV411	viability	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	1.9367139455446578	[297,234]	[839,411]	9	hSpCas9	negative selection	4603450
33636524	33636546	15	-	27760321	MV411	viability	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	-0.11628584496324557	[702,610]	[392,407]	-1	hSpCas9	negative selection	4603451
33652782	33652804	15	+	27760321	MV411	viability	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	0.8180284027264076	[617,514]	[310,1174]	6	hSpCas9	negative selection	4603452
33586085	33586107	15	-	27760321	HL60	viability	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	-0.1726194218108001	[657,550]	[282,598]	-2	hSpCas9	negative selection	4686911
33635761	33635783	15	+	27760321	HL60	viability	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	0.3413889561133767	[560,477]	[598,468]	4	hSpCas9	negative selection	4686912
33636436	33636458	15	+	27760321	HL60	viability	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	-0.30796070600959136	[297,234]	[148,201]	-3	hSpCas9	negative selection	4686913
33636524	33636546	15	-	27760321	HL60	viability	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	0.2783147498177396	[702,610]	[525,779]	3	hSpCas9	negative selection	4686914
33652782	33652804	15	+	27760321	HL60	viability	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	0.9658055906283517	[617,514]	[835,967]	9	hSpCas9	negative selection	4686915
33586085	33586107	15	-	27760321	HT1080	viability	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	1.006257521198028	[550,429]	[539,230]	5	hSpCas9	negative selection	4770374
33635761	33635783	15	+	27760321	HT1080	viability	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	1.4176287689416571	[477,372]	[406,502]	7	hSpCas9	negative selection	4770375
33636436	33636458	15	+	27760321	HT1080	viability	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	-0.20028549936471862	[234,183]	[96,45]	-1	hSpCas9	negative selection	4770376
33636524	33636546	15	-	27760321	HT1080	viability	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	1.3790151566644693	[610,476]	[408,732]	7	hSpCas9	negative selection	4770377
33652782	33652804	15	+	27760321	HT1080	viability	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	1.8254629780237486	[514,401]	[1044,211]	8	hSpCas9	negative selection	4770378
33586085	33586107	15	-	27760321	HT29	viability after 7 days	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	0.45335919438446465	[550,429]	[868,825,893]	7	hSpCas9	negative selection	4853837
33635761	33635783	15	+	27760321	HT29	viability after 7 days	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	-0.156915635531517	[477,372]	[416,462,577]	-2	hSpCas9	negative selection	4853838
33636436	33636458	15	+	27760321	HT29	viability after 7 days	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	-0.639404022929053	[234,183]	[182,98,235]	-7	hSpCas9	negative selection	4853839
33636524	33636546	15	-	27760321	HT29	viability after 7 days	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	0.058308880562954135	[610,476]	[550,480,1113]	0	hSpCas9	negative selection	4853840
33652782	33652804	15	+	27760321	HT29	viability after 7 days	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	0.0506694965710342	[514,401]	[683,504,650]	0	hSpCas9	negative selection	4853841
33586085	33586107	15	-	27760321	HT29	viability after 25 days	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	1.0729745514369455	[550,429]	[1087,1375,1065]	9	hSpCas9	negative selection	4937300
33635761	33635783	15	+	27760321	HT29	viability after 25 days	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	0.5240693446175481	[477,372]	[638,688,780]	6	hSpCas9	negative selection	4937301
33636436	33636458	15	+	27760321	HT29	viability after 25 days	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	0.25509321615032987	[234,183]	[177,362,326]	2	hSpCas9	negative selection	4937302
33636524	33636546	15	-	27760321	HT29	viability after 25 days	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	0.3461866463284432	[610,476]	[1004,579,768]	3	hSpCas9	negative selection	4937303
33652782	33652804	15	+	27760321	HT29	viability after 25 days	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	0.8338589960069768	[514,401]	[987,815,999]	8	hSpCas9	negative selection	4937304
33586085	33586107	15	-	27760321	HT29	viability after 22 days	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	0.9935531763308467	[550,429]	[1015,1252,1120]	9	hSpCas9	negative selection	5020763
33635761	33635783	15	+	27760321	HT29	viability after 22 days	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	0.37298359537002945	[477,372]	[632,654,622]	4	hSpCas9	negative selection	5020764
33636436	33636458	15	+	27760321	HT29	viability after 22 days	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	0.4230592373930671	[234,183]	[208,284,484]	4	hSpCas9	negative selection	5020765
33636524	33636546	15	-	27760321	HT29	viability after 22 days	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	-0.01940157232696149	[610,476]	[613,590,656]	0	hSpCas9	negative selection	5020766
33652782	33652804	15	+	27760321	HT29	viability after 22 days	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	0.8716110420711968	[514,401]	[1026,904,975]	8	hSpCas9	negative selection	5020767
33586085	33586107	15	-	27760321	HT29	viability after 19 days	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	0.7003225346976791	[550,429]	[1146,765,847]	7	hSpCas9	negative selection	5104226
33635761	33635783	15	+	27760321	HT29	viability after 19 days	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	0.713855861407997	[477,372]	[605,759,999]	7	hSpCas9	negative selection	5104227
33636436	33636458	15	+	27760321	HT29	viability after 19 days	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	0.18722057287634086	[234,183]	[327,245,250]	1	hSpCas9	negative selection	5104228
33636524	33636546	15	-	27760321	HT29	viability after 19 days	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	0.2843109159655317	[610,476]	[932,762,600]	2	hSpCas9	negative selection	5104229
33652782	33652804	15	+	27760321	HT29	viability after 19 days	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	0.4740270307373502	[514,401]	[1104,631,495]	5	hSpCas9	negative selection	5104230
33586085	33586107	15	-	27760321	HT29	viability after 16 days	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	0.7937547949920416	[550,429]	[1100,1027,736]	8	hSpCas9	negative selection	5187689
33635761	33635783	15	+	27760321	HT29	viability after 16 days	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	0.1483297985013481	[477,372]	[777,502,325]	1	hSpCas9	negative selection	5187690
33636436	33636458	15	+	27760321	HT29	viability after 16 days	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	0.01388763797946635	[234,183]	[258,166,287]	0	hSpCas9	negative selection	5187691
33636524	33636546	15	-	27760321	HT29	viability after 16 days	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	0.23875213683770058	[610,476]	[885,766,515]	2	hSpCas9	negative selection	5187692
33652782	33652804	15	+	27760321	HT29	viability after 16 days	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	0.5820012457622911	[514,401]	[781,762,759]	6	hSpCas9	negative selection	5187693
33586085	33586107	15	-	27760321	HT29	viability after 13 days	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	0.8775021626204156	[550,429]	[1299,1037,811]	9	hSpCas9	negative selection	5271152
33635761	33635783	15	+	27760321	HT29	viability after 13 days	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	0.3283961669241924	[477,372]	[640,764,462]	4	hSpCas9	negative selection	5271153
33636436	33636458	15	+	27760321	HT29	viability after 13 days	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	0.18685474742138797	[234,183]	[217,297,311]	2	hSpCas9	negative selection	5271154
33636524	33636546	15	-	27760321	HT29	viability after 13 days	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	0.31095034850450787	[610,476]	[647,953,748]	4	hSpCas9	negative selection	5271155
33652782	33652804	15	+	27760321	HT29	viability after 13 days	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	0.1510097085180273	[514,401]	[671,482,614]	1	hSpCas9	negative selection	5271156
33586085	33586107	15	-	27760321	HT29	viability after 10 days	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	0.797000915636821	[550,429]	[982,959,1241]	9	hSpCas9	negative selection	5354615
33635761	33635783	15	+	27760321	HT29	viability after 10 days	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	0.1188735690800331	[477,372]	[640,476,608]	1	hSpCas9	negative selection	5354616
33636436	33636458	15	+	27760321	HT29	viability after 10 days	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	0.39808343115987604	[234,183]	[320,310,399]	5	hSpCas9	negative selection	5354617
33636524	33636546	15	-	27760321	HT29	viability after 10 days	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	-0.26091954576416454	[610,476]	[607,458,628]	-3	hSpCas9	negative selection	5354618
33652782	33652804	15	+	27760321	HT29	viability after 10 days	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	0.5071457652415946	[514,401]	[930,726,780]	7	hSpCas9	negative selection	5354619
33586085	33586107	15	-	27760321	MOLM13	viability	CGCCCGTGCTTATCCAACAGGG	RYR3	ENSG00000198838	0.6513066077931353	[657,550]	[512,550]	4	hSpCas9	negative selection	5438078
33635761	33635783	15	+	27760321	MOLM13	viability	GTCGACCTGATGTCGAGCTGGG	RYR3	ENSG00000198838	0.17677333788325908	[560,477]	[259,389]	1	hSpCas9	negative selection	5438079
33636436	33636458	15	+	27760321	MOLM13	viability	GTCGGATGTATGATTAACCTGG	RYR3	ENSG00000198838	0.07375628784201516	[297,234]	[59,239]	0	hSpCas9	negative selection	5438080
33636524	33636546	15	-	27760321	MOLM13	viability	TCAATCTCGTAGTCAGCGAAGG	RYR3	ENSG00000198838	0.8062611729695142	[702,610]	[799,515]	5	hSpCas9	negative selection	5438081
33652782	33652804	15	+	27760321	MOLM13	viability	AATCGGAGCAACGTGGACCTGG	RYR3	ENSG00000198838	0.5932958405219337	[617,514]	[322,613]	4	hSpCas9	negative selection	5438082
33310986	33311009	15	+	27661255	K562	viability	GCGGCTGCCGGGGGAAGCAGAGG	RYR3	ENSG00000198838	0.10173710079930665	[431,426]	[425,318]	3	dCas9-KRAB	negative selection	5509080
33311179	33311202	15	-	27661255	K562	viability	GCACCGGGCACCCGGCACCGCGG	RYR3	ENSG00000198838	0.08432324614511189	[1024,942]	[961,725]	3	dCas9-KRAB	negative selection	5509081
33311339	33311362	15	-	27661255	K562	viability	GGAGAGCGAGCGGTCCTAGGTGG	RYR3	ENSG00000198838	0.344490284763351	[1005,1188]	[1220,1014]	9	dCas9-KRAB	negative selection	5509082
33311387	33311410	15	-	27661255	K562	viability	GGCTGAAGTTTGGGCATCAAGGG	RYR3	ENSG00000198838	0.39570419775713817	[811,1075]	[1114,877]	9	dCas9-KRAB	negative selection	5509083
33311408	33311431	15	-	27661255	K562	viability	GGACAACCGCGAACAAACCCCGG	RYR3	ENSG00000198838	0.06582613240774915	[416,409]	[408,291]	2	dCas9-KRAB	negative selection	5509084
33311462	33311485	15	-	27661255	K562	viability	GTGTCAGAGGGCCGACCCCGGGG	RYR3	ENSG00000198838	-0.2829222532865098	[731,812]	[536,479]	-6	dCas9-KRAB	negative selection	5509085
33748491	33748514	15	-	27260156	BXPC3	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.28491765447663386	[217]	[263,242,322,283]	6	hSpCas9	negative selection	5568617
33748248	33748271	15	-	27260156	BXPC3	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.5527087686200848	[191]	[265,221,296,412]	9	hSpCas9	negative selection	5568618
33748199	33748222	15	+	27260156	BXPC3	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.1318411160479913	[294]	[300,272,309,491]	3	hSpCas9	negative selection	5568619
33749998	33750021	15	+	27260156	BXPC3	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.08826535227545451	[696]	[605,545,825,791]	-2	hSpCas9	negative selection	5632871
33748517	33748540	15	-	27260156	BXPC3	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	-0.09423168631822154	[415]	[358,398,433,445]	-2	hSpCas9	negative selection	5632872
33749969	33749992	15	+	27260156	BXPC3	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	0.05217633585118964	[345]	[275,342,395,512]	1	hSpCas9	negative selection	5632873
33748491	33748514	15	-	27260156	A673	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.1533146362285488	[217]	[390,279,204,300]	3	hSpCas9	negative selection	5689868
33748248	33748271	15	-	27260156	A673	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.3248828747616307	[191]	[308,250,317,278]	7	hSpCas9	negative selection	5689869
33748199	33748222	15	+	27260156	A673	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.19536763671652313	[294]	[420,472,355,369]	4	hSpCas9	negative selection	5689870
33749998	33750021	15	+	27260156	A673	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.19675341595529994	[696]	[802,688,707,728]	-5	hSpCas9	negative selection	5754122
33748517	33748540	15	-	27260156	A673	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.11094105936436645	[415]	[588,597,431,542]	2	hSpCas9	negative selection	5754123
33749969	33749992	15	+	27260156	A673	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.048640671903019184	[345]	[449,388,328,446]	-1	hSpCas9	negative selection	5754124
33748491	33748514	15	-	27260156	A375	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.14116694218165338	[217]	[376,342,218,201]	2	hSpCas9	negative selection	5811119
33748248	33748271	15	-	27260156	A375	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.439172075763574	[191]	[277,235,383,306]	6	hSpCas9	negative selection	5811120
33748199	33748222	15	+	27260156	A375	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.16344600092063588	[294]	[361,413,311,449]	2	hSpCas9	negative selection	5811121
33749998	33750021	15	+	27260156	A375	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.09354067485908624	[696]	[988,1036,1012,500]	1	hSpCas9	negative selection	5875373
33748517	33748540	15	-	27260156	A375	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.37634906281975355	[415]	[809,445,627,613]	5	hSpCas9	negative selection	5875374
33749969	33749992	15	+	27260156	A375	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.6182081986646843	[345]	[287,300,218,250]	-7	hSpCas9	negative selection	5875375
33748491	33748514	15	-	27260156	COLO741	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.0593750486960376	[217]	[264,252,281]	-1	hSpCas9	negative selection	5932370
33748248	33748271	15	-	27260156	COLO741	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.49626208836289076	[191]	[476,194,373]	8	hSpCas9	negative selection	5932371
33748199	33748222	15	+	27260156	COLO741	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.2618104333579463	[294]	[584,359,422]	5	hSpCas9	negative selection	5932372
33749998	33750021	15	+	27260156	COLO741	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.14422001289397984	[696]	[834,886,703]	-3	hSpCas9	negative selection	5996624
33748517	33748540	15	-	27260156	COLO741	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	-0.05497430366478681	[415]	[564,555,423]	-1	hSpCas9	negative selection	5996625
33749969	33749992	15	+	27260156	COLO741	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.38669094937535975	[345]	[352,352,310]	-7	hSpCas9	negative selection	5996626
33748491	33748514	15	-	27260156	CAL120	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.43856871370873796	[217]	[529,272,324]	6	hSpCas9	negative selection	6053621
33748248	33748271	15	-	27260156	CAL120	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.24558538449018963	[191]	[429,172,268]	3	hSpCas9	negative selection	6053622
33748199	33748222	15	+	27260156	CAL120	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.24784462857872203	[294]	[395,384,518]	3	hSpCas9	negative selection	6053623
33749998	33750021	15	+	27260156	CAL120	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.2032261269536753	[696]	[1223,653,457]	-3	hSpCas9	negative selection	6117875
33748517	33748540	15	-	27260156	CAL120	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.005224734063893899	[415]	[512,444,597]	0	hSpCas9	negative selection	6117876
33749969	33749992	15	+	27260156	CAL120	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.015599689675998174	[345]	[494,478,315]	0	hSpCas9	negative selection	6117877
33748491	33748514	15	-	27260156	CADOES1	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.4096150717310819	[217]	[285,196,275,319]	6	hSpCas9	negative selection	6174872
33748248	33748271	15	-	27260156	CADOES1	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.16439751996988994	[191]	[355,168,152,118]	3	hSpCas9	negative selection	6174873
33748199	33748222	15	+	27260156	CADOES1	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.1420067588332713	[294]	[282,374,331,217]	2	hSpCas9	negative selection	6174874
33749998	33750021	15	+	27260156	CADOES1	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.006990871643381968	[696]	[467,790,707,612]	0	hSpCas9	negative selection	6239126
33748517	33748540	15	-	27260156	CADOES1	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.13668828184828877	[415]	[564,382,352,398]	2	hSpCas9	negative selection	6239127
33749969	33749992	15	+	27260156	CADOES1	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.3741605897915212	[345]	[306,306,159,217]	-6	hSpCas9	negative selection	6239128
33748491	33748514	15	-	27260156	EWS502	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.05251118666351662	[217]	[196,217,307,240]	0	hSpCas9	negative selection	6296123
33748248	33748271	15	-	27260156	EWS502	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.29817743707144617	[191]	[183,221,302,303]	5	hSpCas9	negative selection	6296124
33748199	33748222	15	+	27260156	EWS502	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.4222178669150597	[294]	[517,328,389,427]	7	hSpCas9	negative selection	6296125
33749998	33750021	15	+	27260156	EWS502	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.0973573807210516	[696]	[482,614,850,1287]	1	hSpCas9	negative selection	6360377
33748517	33748540	15	-	27260156	EWS502	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	-0.0725663473979927	[415]	[412,364,467,432]	-1	hSpCas9	negative selection	6360378
33749969	33749992	15	+	27260156	EWS502	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	0.18061188034311926	[345]	[445,389,388,432]	3	hSpCas9	negative selection	6360379
33748491	33748514	15	-	27260156	EW8	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.5611275974968245	[217]	[152,301,290,278]	8	hSpCas9	negative selection	6417374
33748248	33748271	15	-	27260156	EW8	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	-0.12185127459590595	[191]	[157,194,74,156]	-2	hSpCas9	negative selection	6417375
33748199	33748222	15	+	27260156	EW8	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.45239817096599205	[294]	[355,413,257,294]	7	hSpCas9	negative selection	6417376
33749998	33750021	15	+	27260156	EW8	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.1849719607245744	[696]	[644,500,441,423]	-3	hSpCas9	negative selection	6481628
33748517	33748540	15	-	27260156	EW8	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.24234425190474973	[415]	[403,344,417,423]	4	hSpCas9	negative selection	6481629
33749969	33749992	15	+	27260156	EW8	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.19070488330392443	[345]	[396,174,236,190]	-4	hSpCas9	negative selection	6481630
33748491	33748514	15	-	27260156	CORL105	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.05689570086165907	[217]	[247,221,296,222]	-1	hSpCas9	negative selection	6538625
33748248	33748271	15	-	27260156	CORL105	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.19935126792311308	[191]	[256,185,349,254]	4	hSpCas9	negative selection	6538626
33748199	33748222	15	+	27260156	CORL105	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.18359106228229433	[294]	[437,400,514,235]	3	hSpCas9	negative selection	6538627
33749998	33750021	15	+	27260156	CORL105	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.2186654295895088	[696]	[798,658,719,633]	-4	hSpCas9	negative selection	6602879
33748517	33748540	15	-	27260156	CORL105	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.012889905492973586	[415]	[505,466,545,455]	0	hSpCas9	negative selection	6602880
33749969	33749992	15	+	27260156	CORL105	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.29423497215829775	[345]	[351,345,362,265]	-5	hSpCas9	negative selection	6602881
33748491	33748514	15	-	27260156	HS294T	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.4537440653864866	[217]	[165,77,91,122]	6	hSpCas9	negative selection	6659876
33748248	33748271	15	-	27260156	HS294T	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.03777659356754315	[191]	[81,84,68,65]	0	hSpCas9	negative selection	6659877
33748199	33748222	15	+	27260156	HS294T	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	-0.28102140788755536	[294]	[50,75,103,159]	-4	hSpCas9	negative selection	6659878
33749998	33750021	15	+	27260156	HS294T	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.48573703021698167	[696]	[633,269,234,341]	6	hSpCas9	negative selection	6724130
33748517	33748540	15	-	27260156	HS294T	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.5223724600339056	[415]	[186,190,264,296]	7	hSpCas9	negative selection	6724131
33749969	33749992	15	+	27260156	HS294T	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.4689121740914237	[345]	[75,97,68,154]	-6	hSpCas9	negative selection	6724132
33748491	33748514	15	-	27260156	HCC44	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.4292267973659858	[217]	[536,378,190,209]	7	hSpCas9	negative selection	6781127
33748248	33748271	15	-	27260156	HCC44	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.7058911238441953	[191]	[453,321,366,288]	9	hSpCas9	negative selection	6781128
33748199	33748222	15	+	27260156	HCC44	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	-0.17750013615311533	[294]	[305,260,341,282]	-3	hSpCas9	negative selection	6781129
33749998	33750021	15	+	27260156	HCC44	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.24135032401513534	[696]	[1024,939,1185,629]	4	hSpCas9	negative selection	6845381
33748517	33748540	15	-	27260156	HCC44	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	-0.01879984163322579	[415]	[444,375,790,313]	0	hSpCas9	negative selection	6845382
33749969	33749992	15	+	27260156	HCC44	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.06723330331759658	[345]	[332,353,522,307]	-1	hSpCas9	negative selection	6845383
33748491	33748514	15	-	27260156	G402	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.1954847305209273	[217]	[375,388,216,252]	2	hSpCas9	negative selection	6902378
33748248	33748271	15	-	27260156	G402	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.8253306081646101	[191]	[343,459,299,540]	8	hSpCas9	negative selection	6902379
33748199	33748222	15	+	27260156	G402	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	1.0295366275016673	[294]	[989,324,911,722]	9	hSpCas9	negative selection	6902380
33749998	33750021	15	+	27260156	G402	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.30396090935132203	[696]	[1269,1059,952,949]	4	hSpCas9	negative selection	6966632
33748517	33748540	15	-	27260156	G402	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.3670620760652073	[415]	[929,644,778,317]	4	hSpCas9	negative selection	6966633
33749969	33749992	15	+	27260156	G402	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	0.12448144697156632	[345]	[459,486,291,594]	1	hSpCas9	negative selection	6966634
33748491	33748514	15	-	27260156	L33	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.40178869205501544	[217]	[297,102,175,321]	8	hSpCas9	negative selection	7023629
33748248	33748271	15	-	27260156	L33	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.003256499765278642	[191]	[257,84,104,135]	0	hSpCas9	negative selection	7023630
33748199	33748222	15	+	27260156	L33	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	-0.013857323562354695	[294]	[305,152,148,251]	0	hSpCas9	negative selection	7023631
33749998	33750021	15	+	27260156	L33	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.38856475922879946	[696]	[441,181,371,652]	-7	hSpCas9	negative selection	7087883
33748517	33748540	15	-	27260156	L33	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	-0.3235864895201456	[415]	[282,152,213,333]	-6	hSpCas9	negative selection	7087884
33749969	33749992	15	+	27260156	L33	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.04048907099044635	[345]	[258,166,184,385]	-1	hSpCas9	negative selection	7087885
33748491	33748514	15	-	27260156	K562	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.792415917916794	[217]	[490,498,202,184]	8	hSpCas9	negative selection	7144880
33748248	33748271	15	-	27260156	K562	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	1.0958564616291593	[191]	[708,291,202,284]	9	hSpCas9	negative selection	7144881
33748199	33748222	15	+	27260156	K562	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	-0.14067320072243905	[294]	[300,189,179,275]	-2	hSpCas9	negative selection	7144882
33749998	33750021	15	+	27260156	K562	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.1641122300539723	[696]	[740,547,426,509]	-2	hSpCas9	negative selection	7209134
33748517	33748540	15	-	27260156	K562	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.5415118805927437	[415]	[347,511,551,698]	7	hSpCas9	negative selection	7209135
33749969	33749992	15	+	27260156	K562	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.2704710911610271	[345]	[176,448,328,85]	-3	hSpCas9	negative selection	7209136
33748491	33748514	15	-	27260156	HT29	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.24776292085900975	[217]	[324,416,263,265]	5	hSpCas9	negative selection	7266131
33748248	33748271	15	-	27260156	HT29	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.07135774768284775	[191]	[286,174,328,191]	1	hSpCas9	negative selection	7266132
33748199	33748222	15	+	27260156	HT29	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.29547963490911566	[294]	[410,484,441,422]	6	hSpCas9	negative selection	7266133
33749998	33750021	15	+	27260156	HT29	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.027606658900335312	[696]	[815,889,868,756]	0	hSpCas9	negative selection	7330385
33748517	33748540	15	-	27260156	HT29	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	-0.07065678256728267	[415]	[468,714,377,390]	-1	hSpCas9	negative selection	7330386
33749969	33749992	15	+	27260156	HT29	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.148833573691583	[345]	[476,279,388,368]	-3	hSpCas9	negative selection	7330387
33748491	33748514	15	-	27260156	MHHES1	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.27413742133610985	[217]	[194,308,383,284]	5	hSpCas9	negative selection	7387382
33748248	33748271	15	-	27260156	MHHES1	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.4539851080699202	[191]	[355,416,241,203]	7	hSpCas9	negative selection	7387383
33748199	33748222	15	+	27260156	MHHES1	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	-0.09401077611527997	[294]	[399,349,378,159]	-2	hSpCas9	negative selection	7387384
33749998	33750021	15	+	27260156	MHHES1	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.19677301092393262	[696]	[872,728,672,515]	-4	hSpCas9	negative selection	7451636
33748517	33748540	15	-	27260156	MHHES1	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	-0.25729677225724845	[415]	[381,443,361,377]	-5	hSpCas9	negative selection	7451637
33749969	33749992	15	+	27260156	MHHES1	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.22012135739495575	[345]	[313,447,379,223]	-4	hSpCas9	negative selection	7451638
33748491	33748514	15	-	27260156	MEWO	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.01730512252564531	[217]	[270,196,149]	0	hSpCas9	negative selection	7508633
33748248	33748271	15	-	27260156	MEWO	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.4260558027910605	[191]	[282,248,199]	8	hSpCas9	negative selection	7508634
33748199	33748222	15	+	27260156	MEWO	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.19794363163537804	[294]	[410,307,248]	4	hSpCas9	negative selection	7508635
33749998	33750021	15	+	27260156	MEWO	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.09474194000568176	[696]	[767,665,427]	-2	hSpCas9	negative selection	7572887
33748517	33748540	15	-	27260156	MEWO	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	-0.18605659388726153	[415]	[397,354,283]	-4	hSpCas9	negative selection	7572888
33749969	33749992	15	+	27260156	MEWO	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	0.051080616190932626	[345]	[473,313,244]	1	hSpCas9	negative selection	7572889
33748491	33748514	15	-	27260156	LNCAPCLONEFGC	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.10100547237076118	[217]	[232,170,249,200]	1	hSpCas9	negative selection	7629884
33748248	33748271	15	-	27260156	LNCAPCLONEFGC	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.7254004899430562	[191]	[222,305,313,310]	9	hSpCas9	negative selection	7629885
33748199	33748222	15	+	27260156	LNCAPCLONEFGC	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.40870799957099246	[294]	[293,404,370,348]	6	hSpCas9	negative selection	7629886
33749998	33750021	15	+	27260156	LNCAPCLONEFGC	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.04426309600635725	[696]	[541,613,823,653]	0	hSpCas9	negative selection	7694138
33748517	33748540	15	-	27260156	LNCAPCLONEFGC	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.3768138564200797	[415]	[450,476,593,451]	6	hSpCas9	negative selection	7694139
33749969	33749992	15	+	27260156	LNCAPCLONEFGC	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.09452612444930908	[345]	[272,232,364,317]	-1	hSpCas9	negative selection	7694140
33748491	33748514	15	-	27260156	PANC0327	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.36608312766182594	[217]	[138,156,240,463]	5	hSpCas9	negative selection	7751135
33748248	33748271	15	-	27260156	PANC0327	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	1.035972149305506	[191]	[286,502,378,204]	9	hSpCas9	negative selection	7751136
33748199	33748222	15	+	27260156	PANC0327	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	-0.014620804206603277	[294]	[200,140,289,415]	0	hSpCas9	negative selection	7751137
33749998	33750021	15	+	27260156	PANC0327	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.13708109002695446	[696]	[836,620,747,537]	2	hSpCas9	negative selection	7815389
33748517	33748540	15	-	27260156	PANC0327	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.37927440725221007	[415]	[337,528,281,754]	5	hSpCas9	negative selection	7815390
33749969	33749992	15	+	27260156	PANC0327	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.15915709226888763	[345]	[362,277,352,113]	-2	hSpCas9	negative selection	7815391
33748491	33748514	15	-	27260156	NCIH2009	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.3251504070917375	[217]	[319,195,228]	-4	hSpCas9	negative selection	7872386
33748248	33748271	15	-	27260156	NCIH2009	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.6455389127796387	[191]	[700,298,315]	8	hSpCas9	negative selection	7872387
33748199	33748222	15	+	27260156	NCIH2009	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.30126647250867417	[294]	[360,382,751]	4	hSpCas9	negative selection	7872388
33749998	33750021	15	+	27260156	NCIH2009	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.159100084594191	[696]	[1065,499,1093]	-2	hSpCas9	negative selection	7936640
33748517	33748540	15	-	27260156	NCIH2009	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.08968858113885876	[415]	[565,621,655]	1	hSpCas9	negative selection	7936641
33749969	33749992	15	+	27260156	NCIH2009	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.6066806051240192	[345]	[410,335,222]	-6	hSpCas9	negative selection	7936642
33748491	33748514	15	-	27260156	NCIH1373	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.8398043042412915	[217]	[190,76,133,41]	-7	hSpCas9	negative selection	7993637
33748248	33748271	15	-	27260156	NCIH1373	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.4460120540648137	[191]	[131,119,682,56]	4	hSpCas9	negative selection	7993638
33748199	33748222	15	+	27260156	NCIH1373	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	-0.7225278353257291	[294]	[209,119,308,43]	-6	hSpCas9	negative selection	7993639
33749998	33750021	15	+	27260156	NCIH1373	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.17654556152667122	[696]	[1267,593,831,243]	1	hSpCas9	negative selection	8057891
33748517	33748540	15	-	27260156	NCIH1373	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.5920714291517619	[415]	[1112,906,364,119]	6	hSpCas9	negative selection	8057892
33749969	33749992	15	+	27260156	NCIH1373	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.20505412411531854	[345]	[444,136,133,181]	-2	hSpCas9	negative selection	8057893
33748491	33748514	15	-	27260156	PATU8902	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.20257104175297624	[217]	[292,82,301,377]	-2	hSpCas9	negative selection	8114888
33748248	33748271	15	-	27260156	PATU8902	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	1.0914749806556352	[191]	[663,707,396,546]	9	hSpCas9	negative selection	8114889
33748199	33748222	15	+	27260156	PATU8902	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.523802000191344	[294]	[447,368,465,1178]	5	hSpCas9	negative selection	8114890
33749998	33750021	15	+	27260156	PATU8902	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.28505648774012793	[696]	[1294,1094,792,1699]	3	hSpCas9	negative selection	8179142
33748517	33748540	15	-	27260156	PATU8902	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.7211640190128432	[415]	[587,1624,723,940]	7	hSpCas9	negative selection	8179143
33749969	33749992	15	+	27260156	PATU8902	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.8741660097659381	[345]	[274,211,276,283]	-7	hSpCas9	negative selection	8179144
33748491	33748514	15	-	27260156	PANC1	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.42308932561510015	[217]	[240,238,247,266]	6	hSpCas9	negative selection	8236139
33748248	33748271	15	-	27260156	PANC1	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.194948331219452	[191]	[182,170,208,185]	3	hSpCas9	negative selection	8236140
33748199	33748222	15	+	27260156	PANC1	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.5710767184416639	[294]	[333,669,343,235]	8	hSpCas9	negative selection	8236141
33749998	33750021	15	+	27260156	PANC1	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.08941716916337183	[696]	[590,836,657,513]	1	hSpCas9	negative selection	8300393
33748517	33748540	15	-	27260156	PANC1	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	-0.09051037697411474	[415]	[273,369,356,342]	-1	hSpCas9	negative selection	8300394
33749969	33749992	15	+	27260156	PANC1	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	0.05684265944505279	[345]	[220,363,397,268]	0	hSpCas9	negative selection	8300395
33748491	33748514	15	-	27260156	PANC0813	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.03473997465330125	[217]	[350,306,235,121]	0	hSpCas9	negative selection	8357390
33748248	33748271	15	-	27260156	PANC0813	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	-0.13667264331199025	[191]	[244,222,104,247]	-2	hSpCas9	negative selection	8357391
33748199	33748222	15	+	27260156	PANC0813	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.22546710303691753	[294]	[558,567,245,267]	3	hSpCas9	negative selection	8357392
33749998	33750021	15	+	27260156	PANC0813	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.07119423907176314	[696]	[904,658,1016,862]	1	hSpCas9	negative selection	8421644
33748517	33748540	15	-	27260156	PANC0813	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	-0.20117591120700984	[415]	[524,365,364,450]	-3	hSpCas9	negative selection	8421645
33749969	33749992	15	+	27260156	PANC0813	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.878834057297665	[345]	[287,111,282,207]	-8	hSpCas9	negative selection	8421646
33748491	33748514	15	-	27260156	RDES	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.4033569587618995	[217]	[264,397,369,284]	6	hSpCas9	negative selection	8478641
33748248	33748271	15	-	27260156	RDES	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.6328628952268446	[191]	[289,376,335,366]	8	hSpCas9	negative selection	8478642
33748199	33748222	15	+	27260156	RDES	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.001403615837338279	[294]	[311,281,284,502]	0	hSpCas9	negative selection	8478643
33749998	33750021	15	+	27260156	RDES	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.10108617499810013	[696]	[656,832,847,1168]	1	hSpCas9	negative selection	8542895
33748517	33748540	15	-	27260156	RDES	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.19159877660642696	[415]	[502,362,681,671]	3	hSpCas9	negative selection	8542896
33749969	33749992	15	+	27260156	RDES	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	0.043651202854710136	[345]	[345,432,404,462]	0	hSpCas9	negative selection	8542897
33748491	33748514	15	-	27260156	PC3	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.07453393970534372	[217]	[173,189,319,172]	-2	hSpCas9	negative selection	8599892
33748248	33748271	15	-	27260156	PC3	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.8306302621158972	[191]	[304,146,772,284]	9	hSpCas9	negative selection	8599893
33748199	33748222	15	+	27260156	PC3	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.7250940787477405	[294]	[299,355,872,614]	9	hSpCas9	negative selection	8599894
33749998	33750021	15	+	27260156	PC3	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.19091758403126402	[696]	[403,609,1069,554]	-4	hSpCas9	negative selection	8664146
33748517	33748540	15	-	27260156	PC3	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.06207822529883773	[415]	[311,413,611,470]	1	hSpCas9	negative selection	8664147
33749969	33749992	15	+	27260156	PC3	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	0.2575570900142702	[345]	[339,347,735,331]	5	hSpCas9	negative selection	8664148
33748491	33748514	15	-	27260156	PATU8988T	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.035565756718071384	[217]	[83,258,222,308]	0	hSpCas9	negative selection	8721143
33748248	33748271	15	-	27260156	PATU8988T	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.5038490189453848	[191]	[242,131,312,358]	8	hSpCas9	negative selection	8721144
33748199	33748222	15	+	27260156	PATU8988T	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.38031632707602603	[294]	[294,322,507,349]	6	hSpCas9	negative selection	8721145
33749998	33750021	15	+	27260156	PATU8988T	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.23525955957389355	[696]	[566,537,586,594]	-4	hSpCas9	negative selection	8785397
33748517	33748540	15	-	27260156	PATU8988T	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.14910094255034223	[415]	[551,543,250,447]	2	hSpCas9	negative selection	8785398
33749969	33749992	15	+	27260156	PATU8988T	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	0.5510952726075407	[345]	[336,621,417,604]	8	hSpCas9	negative selection	8785399
33748491	33748514	15	-	27260156	T47D	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.02163354352808411	[217]	[295,251,272,176]	0	hSpCas9	negative selection	8842394
33748248	33748271	15	-	27260156	T47D	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.2688705207184754	[191]	[226,381,193,265]	6	hSpCas9	negative selection	8842395
33748199	33748222	15	+	27260156	T47D	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.4681679305629072	[294]	[459,358,561,530]	8	hSpCas9	negative selection	8842396
33749998	33750021	15	+	27260156	T47D	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.030004999749751016	[696]	[847,778,880,810]	0	hSpCas9	negative selection	8906648
33748517	33748540	15	-	27260156	T47D	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.032000563129302884	[415]	[418,533,541,481]	0	hSpCas9	negative selection	8906649
33749969	33749992	15	+	27260156	T47D	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.13088385103048017	[345]	[398,374,299,399]	-3	hSpCas9	negative selection	8906650
33748491	33748514	15	-	27260156	SU8686	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.2527045347216592	[217]	[314,208,242,260]	4	hSpCas9	negative selection	8963645
33748248	33748271	15	-	27260156	SU8686	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.22307214388656038	[191]	[174,183,263,285]	4	hSpCas9	negative selection	8963646
33748199	33748222	15	+	27260156	SU8686	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.31187447829204745	[294]	[353,312,340,464]	5	hSpCas9	negative selection	8963647
33749998	33750021	15	+	27260156	SU8686	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.055606168838832515	[696]	[543,667,745,978]	0	hSpCas9	negative selection	9027899
33748517	33748540	15	-	27260156	SU8686	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.07001955869015093	[415]	[436,468,419,389]	1	hSpCas9	negative selection	9027900
33749969	33749992	15	+	27260156	SU8686	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.35880273399479456	[345]	[257,255,234,330]	-5	hSpCas9	negative selection	9027901
33748491	33748514	15	-	27260156	SKES1	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.4554924925714907	[217]	[262,286,335,296]	8	hSpCas9	negative selection	9084896
33748248	33748271	15	-	27260156	SKES1	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.3264369920598492	[191]	[269,165,361,162]	6	hSpCas9	negative selection	9084897
33748199	33748222	15	+	27260156	SKES1	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.14906795844861254	[294]	[367,307,379,256]	3	hSpCas9	negative selection	9084898
33749998	33750021	15	+	27260156	SKES1	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.061590791606262796	[696]	[778,596,470,803]	-1	hSpCas9	negative selection	9149150
33748517	33748540	15	-	27260156	SKES1	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.28501400646712366	[415]	[652,516,429,446]	6	hSpCas9	negative selection	9149151
33749969	33749992	15	+	27260156	SKES1	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.16501298002538678	[345]	[312,386,310,235]	-4	hSpCas9	negative selection	9149152
33748491	33748514	15	-	27260156	TOV112D	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.05649873608727862	[217]	[281,210,277,139]	1	hSpCas9	negative selection	9206147
33748248	33748271	15	-	27260156	TOV112D	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.20386956572361448	[191]	[345,318,103,152]	4	hSpCas9	negative selection	9206148
33748199	33748222	15	+	27260156	TOV112D	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.17637610915404794	[294]	[501,445,213,217]	3	hSpCas9	negative selection	9206149
33749998	33750021	15	+	27260156	TOV112D	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.06864574104600529	[696]	[662,839,674,529]	-1	hSpCas9	negative selection	9270401
33748517	33748540	15	-	27260156	TOV112D	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.09228435511741845	[415]	[511,575,314,411]	1	hSpCas9	negative selection	9270402
33749969	33749992	15	+	27260156	TOV112D	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	0.13034502690318345	[345]	[331,519,343,351]	2	hSpCas9	negative selection	9270403
33748491	33748514	15	-	27260156	TC71	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	-0.04349498828764209	[217]	[242,212,180,273]	-1	hSpCas9	negative selection	9327398
33748248	33748271	15	-	27260156	TC71	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.011464451698530942	[191]	[227,173,208,218]	0	hSpCas9	negative selection	9327399
33748199	33748222	15	+	27260156	TC71	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.3240597709663884	[294]	[267,395,433,492]	7	hSpCas9	negative selection	9327400
33749998	33750021	15	+	27260156	TC71	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	-0.26877757823863563	[696]	[585,538,638,722]	-6	hSpCas9	negative selection	9391652
33748517	33748540	15	-	27260156	TC71	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	-0.21460268187376724	[415]	[349,380,457,343]	-5	hSpCas9	negative selection	9391653
33749969	33749992	15	+	27260156	TC71	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	0.046328252787121715	[345]	[408,407,342,371]	1	hSpCas9	negative selection	9391654
33748491	33748514	15	-	27260156	TC32	viability	GCACAACGTTTGAGAGGTCGAGG	RYR3	ENSG00000198838	0.13671507394894378	[217]	[150,195,379,206]	2	hSpCas9	negative selection	9448649
33748248	33748271	15	-	27260156	TC32	viability	GGTGTCATACCTGGTTGGCCTGG	RYR3	ENSG00000198838	0.46114223364096074	[191]	[254,249,274,196]	7	hSpCas9	negative selection	9448650
33748199	33748222	15	+	27260156	TC32	viability	GAGAAGCTTTGGTTCAACAGCGG	RYR3	ENSG00000198838	0.25603483951596856	[294]	[235,315,451,338]	4	hSpCas9	negative selection	9448651
33749998	33750021	15	+	27260156	TC32	viability	CTGAGAACTATCACAATATCTGG	RYR3	ENSG00000198838	0.240052855133701	[696]	[787,594,1130,653]	4	hSpCas9	negative selection	9512903
33748517	33748540	15	-	27260156	TC32	viability	GGCACTGACCTGGAGCTCTCTGG	RYR3	ENSG00000198838	0.1262584610656008	[415]	[358,435,450,442]	2	hSpCas9	negative selection	9512904
33749969	33749992	15	+	27260156	TC32	viability	TGGGACACAGGGAATGGTGGAGG	RYR3	ENSG00000198838	-0.2647080861939448	[345]	[320,155,320,316]	-5	hSpCas9	negative selection	9512905
33311036	33311059	15	+	27869803	HPAFII	viability after 27 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.33462734009217954	[501]	[328,335,NaN]	2	hSpCas9	negative selection	9553233
33473469	33473492	15	+	27869803	HPAFII	viability after 27 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	-0.4191933634921317	[196]	[119,41,NaN]	-3	hSpCas9	negative selection	9553234
33503697	33503720	15	+	27869803	HPAFII	viability after 27 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.5867846084838642	[543]	[410,444,NaN]	5	hSpCas9	negative selection	9553235
33530617	33530640	15	-	27869803	HPAFII	viability after 27 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	1.0106383370023737	[427]	[586,341,NaN]	8	hSpCas9	negative selection	9553236
33539356	33539379	15	-	27869803	HPAFII	viability after 27 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.9321115354899883	[288]	[254,318,NaN]	7	hSpCas9	negative selection	9553237
33540869	33540892	15	+	27869803	HPAFII	viability after 27 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.38933008889731857	[441]	[257,342,NaN]	3	hSpCas9	negative selection	9553238
33311036	33311059	15	+	27869803	HPAFII	viability after 15 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	-0.009542783008166023	[501]	[789,377,NaN]	0	hSpCas9	negative selection	9635682
33473469	33473492	15	+	27869803	HPAFII	viability after 15 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	-0.013881948947871148	[196]	[324,137,NaN]	0	hSpCas9	negative selection	9635683
33503697	33503720	15	+	27869803	HPAFII	viability after 15 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.08094949164006704	[543]	[922,428,NaN]	0	hSpCas9	negative selection	9635684
33530617	33530640	15	-	27869803	HPAFII	viability after 15 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.6981166410295384	[427]	[1151,493,NaN]	7	hSpCas9	negative selection	9635685
33539356	33539379	15	-	27869803	HPAFII	viability after 15 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.461286030579624	[288]	[463,404,NaN]	5	hSpCas9	negative selection	9635686
33540869	33540892	15	+	27869803	HPAFII	viability after 15 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	-0.05456094403377676	[441]	[642,341,NaN]	0	hSpCas9	negative selection	9635687
33311036	33311059	15	+	27869803	ASPC1	viability after 36 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.19998212581705044	[1301]	[598,673,341]	2	hSpCas9	negative selection	9718131
33473469	33473492	15	+	27869803	ASPC1	viability after 36 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.010268860988906975	[566]	[223,294,103]	0	hSpCas9	negative selection	9718132
33503697	33503720	15	+	27869803	ASPC1	viability after 36 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	-0.36772492598281836	[1855]	[694,469,386]	-4	hSpCas9	negative selection	9718133
33530617	33530640	15	-	27869803	ASPC1	viability after 36 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.7277703350657965	[1108]	[507,961,472]	7	hSpCas9	negative selection	9718134
33539356	33539379	15	-	27869803	ASPC1	viability after 36 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.6084384253473435	[586]	[553,190,235]	6	hSpCas9	negative selection	9718135
33540869	33540892	15	+	27869803	ASPC1	viability after 36 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.4469577808622808	[956]	[361,224,698]	4	hSpCas9	negative selection	9718136
33311036	33311059	15	+	27869803	PATU8988S	viability after 35 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	-0.6984049266439423	[1001]	[332,163,NaN]	-6	hSpCas9	negative selection	9800580
33473469	33473492	15	+	27869803	PATU8988S	viability after 35 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.7564333066005927	[320]	[173,262,NaN]	7	hSpCas9	negative selection	9800581
33503697	33503720	15	+	27869803	PATU8988S	viability after 35 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.4788623546077453	[1315]	[1026,448,NaN]	5	hSpCas9	negative selection	9800582
33530617	33530640	15	-	27869803	PATU8988S	viability after 35 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.3158498810799414	[1049]	[476,575,NaN]	3	hSpCas9	negative selection	9800583
33539356	33539379	15	-	27869803	PATU8988S	viability after 35 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.530356899298857	[540]	[179,449,NaN]	6	hSpCas9	negative selection	9800584
33540869	33540892	15	+	27869803	PATU8988S	viability after 35 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	-0.11350042361008528	[791]	[226,362,NaN]	-1	hSpCas9	negative selection	9800585
33311036	33311059	15	+	27869803	PATU8988S	viability after 31 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	-0.46026140444656793	[1001]	[329,239,NaN]	-5	hSpCas9	negative selection	9883029
33473469	33473492	15	+	27869803	PATU8988S	viability after 31 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.48801442042206816	[320]	[164,197,NaN]	6	hSpCas9	negative selection	9883030
33503697	33503720	15	+	27869803	PATU8988S	viability after 31 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.11905453179070902	[1315]	[601,528,NaN]	1	hSpCas9	negative selection	9883031
33530617	33530640	15	-	27869803	PATU8988S	viability after 31 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	0.2149041290267556	[1049]	[349,658,NaN]	2	hSpCas9	negative selection	9883032
33539356	33539379	15	-	27869803	PATU8988S	viability after 31 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.6493129263242696	[540]	[241,460,NaN]	7	hSpCas9	negative selection	9883033
33540869	33540892	15	+	27869803	PATU8988S	viability after 31 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.026858612800410686	[791]	[220,449,NaN]	0	hSpCas9	negative selection	9883034
33311036	33311059	15	+	27869803	HPAFII	viability after 35 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.2523256563028333	[501]	[186,432,NaN]	1	hSpCas9	negative selection	9965478
33473469	33473492	15	+	27869803	HPAFII	viability after 35 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.26388286473040823	[196]	[202,25,NaN]	1	hSpCas9	negative selection	9965479
33503697	33503720	15	+	27869803	HPAFII	viability after 35 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.8501779926251944	[543]	[606,371,NaN]	5	hSpCas9	negative selection	9965480
33530617	33530640	15	-	27869803	HPAFII	viability after 35 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	1.4339472579177062	[427]	[599,568,NaN]	8	hSpCas9	negative selection	9965481
33539356	33539379	15	-	27869803	HPAFII	viability after 35 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.45841313737915473	[288]	[137,271,NaN]	3	hSpCas9	negative selection	9965482
33540869	33540892	15	+	27869803	HPAFII	viability after 35 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.42357480663013614	[441]	[182,431,NaN]	2	hSpCas9	negative selection	9965483
33311036	33311059	15	+	27869803	HPAFII	viability after 31 days	CTCGGGAGCCATGGCCGAAGGGG	RYR3	ENSG00000198838	0.14392320478278853	[501]	[205,425,NaN]	1	hSpCas9	negative selection	10047927
33473469	33473492	15	+	27869803	HPAFII	viability after 31 days	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	-0.1814560018475842	[196]	[141,48,NaN]	-1	hSpCas9	negative selection	10047928
33503697	33503720	15	+	27869803	HPAFII	viability after 31 days	CAGGAAATGCTTGCCAACACAGG	RYR3	ENSG00000198838	0.684878800787329	[543]	[407,580,NaN]	5	hSpCas9	negative selection	10047929
33530617	33530640	15	-	27869803	HPAFII	viability after 31 days	AACTGCATGGCCGTATAACAGGG	RYR3	ENSG00000198838	1.3152681483948743	[427]	[669,518,NaN]	8	hSpCas9	negative selection	10047930
33539356	33539379	15	-	27869803	HPAFII	viability after 31 days	AGGATGTATAGTCCACCAACAGG	RYR3	ENSG00000198838	0.8999520579974145	[288]	[238,371,NaN]	6	hSpCas9	negative selection	10047931
33540869	33540892	15	+	27869803	HPAFII	viability after 31 days	TCAGGAAGTAGCATCGAAGAAGG	RYR3	ENSG00000198838	0.35530225362293133	[441]	[212,430,NaN]	2	hSpCas9	negative selection	10047932
33603283	33603306	15	+	28162770	P31FUJ	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-4.809151574830827	[333]	[13]	-9	hSpCas9	negative selection	10229229
33530586	33530609	15	+	28162770	P31FUJ	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	0.45059003263152264	[202]	[325]	5	hSpCas9	negative selection	10229230
33662517	33662540	15	-	28162770	P31FUJ	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-4.575194401861457	[141]	[6]	-9	hSpCas9	negative selection	10229231
33662834	33662857	15	+	28162770	P31FUJ	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	0.08912589047298436	[11]	[14]	0	hSpCas9	negative selection	10229232
33700977	33701000	15	-	28162770	P31FUJ	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	0.994608291688694	[40]	[95]	9	hSpCas9	negative selection	10229233
33707025	33707048	15	-	28162770	P31FUJ	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	0.33317719293920467	[101]	[150]	3	hSpCas9	negative selection	10229234
33821561	33821584	15	+	28162770	P31FUJ	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	0.38924961504199773	[255]	[393]	4	hSpCas9	negative selection	10229235
33473469	33473492	15	+	28162770	P31FUJ	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	1.339776571850945	[38]	[115]	9	hSpCas9	negative selection	10229236
33473517	33473540	15	+	28162770	P31FUJ	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	-0.29274474487066066	[343]	[329]	-3	hSpCas9	negative selection	10229237
33503715	33503738	15	+	28162770	P31FUJ	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.7434416723330132	[397]	[782]	8	hSpCas9	negative selection	10229238
33603283	33603306	15	+	28162770	TF1	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	NaN	[NaN]	[12]	1	hSpCas9	negative selection	10398595
33530586	33530609	15	+	28162770	TF1	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	NaN	[NaN]	[313]	1	hSpCas9	negative selection	10398596
33662517	33662540	15	-	28162770	TF1	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	NaN	[NaN]	[7]	1	hSpCas9	negative selection	10398597
33662834	33662857	15	+	28162770	TF1	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	NaN	[NaN]	[36]	1	hSpCas9	negative selection	10398598
33700977	33701000	15	-	28162770	TF1	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	NaN	[NaN]	[35]	1	hSpCas9	negative selection	10398599
33707025	33707048	15	-	28162770	TF1	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	NaN	[NaN]	[155]	1	hSpCas9	negative selection	10398600
33821561	33821584	15	+	28162770	TF1	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	NaN	[NaN]	[197]	1	hSpCas9	negative selection	10398601
33473469	33473492	15	+	28162770	TF1	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	NaN	[NaN]	[164]	1	hSpCas9	negative selection	10398602
33473517	33473540	15	+	28162770	TF1	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	NaN	[NaN]	[279]	1	hSpCas9	negative selection	10398603
33503715	33503738	15	+	28162770	TF1	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	NaN	[NaN]	[478]	1	hSpCas9	negative selection	10398604
33603283	33603306	15	+	28162770	SKM1	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-3.4918530963296748	[69]	[10]	-9	hSpCas9	negative selection	10567961
33530586	33530609	15	+	28162770	SKM1	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	0.2752955033329093	[42]	[91]	2	hSpCas9	negative selection	10567962
33662517	33662540	15	-	28162770	SKM1	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-3.3663222142458156	[34]	[5]	-9	hSpCas9	negative selection	10567963
33662834	33662857	15	+	28162770	SKM1	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	-3.8220016980220053	[7]	[0]	-9	hSpCas9	negative selection	10567964
33700977	33701000	15	-	28162770	SKM1	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	-1.7065244806020692	[23]	[12]	-8	hSpCas9	negative selection	10567965
33707025	33707048	15	-	28162770	SKM1	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	0.38950240717170603	[37]	[87]	4	hSpCas9	negative selection	10567966
33821561	33821584	15	+	28162770	SKM1	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	0.7140512022182043	[59]	[173]	7	hSpCas9	negative selection	10567967
33473469	33473492	15	+	28162770	SKM1	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	1.1039977205342173	[9]	[37]	8	hSpCas9	negative selection	10567968
33473517	33473540	15	+	28162770	SKM1	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	0.3844491794454207	[64]	[149]	4	hSpCas9	negative selection	10567969
33503715	33503738	15	+	28162770	SKM1	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.1460081877335575	[113]	[222]	1	hSpCas9	negative selection	10567970
33603283	33603306	15	+	28162770	SKM1	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-3.4918530963296748	[69]	[10]	-9	hSpCas9	negative selection	10737327
33530586	33530609	15	+	28162770	SKM1	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	0.2752955033329093	[42]	[91]	2	hSpCas9	negative selection	10737328
33662517	33662540	15	-	28162770	SKM1	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-3.3663222142458156	[34]	[5]	-9	hSpCas9	negative selection	10737329
33662834	33662857	15	+	28162770	SKM1	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	-3.8220016980220053	[7]	[0]	-9	hSpCas9	negative selection	10737330
33700977	33701000	15	-	28162770	SKM1	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	-1.7065244806020692	[23]	[12]	-8	hSpCas9	negative selection	10737331
33707025	33707048	15	-	28162770	SKM1	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	0.38950240717170603	[37]	[87]	4	hSpCas9	negative selection	10737332
33821561	33821584	15	+	28162770	SKM1	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	0.7140512022182043	[59]	[173]	7	hSpCas9	negative selection	10737333
33473469	33473492	15	+	28162770	SKM1	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	1.1039977205342173	[9]	[37]	8	hSpCas9	negative selection	10737334
33473517	33473540	15	+	28162770	SKM1	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	0.3844491794454207	[64]	[149]	4	hSpCas9	negative selection	10737335
33503715	33503738	15	+	28162770	SKM1	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.1460081877335575	[113]	[222]	1	hSpCas9	negative selection	10737336
33603283	33603306	15	+	28162770	PL21	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-3.0376280327340437	[282]	[14]	-9	hSpCas9	negative selection	10906693
33530586	33530609	15	+	28162770	PL21	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	-0.6280940372441999	[173]	[48]	-4	hSpCas9	negative selection	10906694
33662517	33662540	15	-	28162770	PL21	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-1.8332833870481302	[130]	[15]	-8	hSpCas9	negative selection	10906695
33662834	33662857	15	+	28162770	PL21	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	-3.0477878989542657	[18]	[0]	-9	hSpCas9	negative selection	10906696
33700977	33701000	15	-	28162770	PL21	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	-1.6072153075682842	[69]	[9]	-8	hSpCas9	negative selection	10906697
33707025	33707048	15	-	28162770	PL21	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	-0.654009519047225	[93]	[25]	-4	hSpCas9	negative selection	10906698
33821561	33821584	15	+	28162770	PL21	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	0.12834893142131004	[205]	[97]	1	hSpCas9	negative selection	10906699
33473469	33473492	15	+	28162770	PL21	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.5277142725178243	[50]	[31]	4	hSpCas9	negative selection	10906700
33473517	33473540	15	+	28162770	PL21	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	1.240078359859464	[284]	[292]	8	hSpCas9	negative selection	10906701
33503715	33503738	15	+	28162770	PL21	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.43611212409581657	[286]	[168]	4	hSpCas9	negative selection	10906702
33603283	33603306	15	+	28162770	P31FUJ	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-4.809151574830827	[333]	[13]	-9	hSpCas9	negative selection	11076059
33530586	33530609	15	+	28162770	P31FUJ	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	0.45059003263152264	[202]	[325]	5	hSpCas9	negative selection	11076060
33662517	33662540	15	-	28162770	P31FUJ	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-4.575194401861457	[141]	[6]	-9	hSpCas9	negative selection	11076061
33662834	33662857	15	+	28162770	P31FUJ	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	0.08912589047298436	[11]	[14]	0	hSpCas9	negative selection	11076062
33700977	33701000	15	-	28162770	P31FUJ	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	0.994608291688694	[40]	[95]	9	hSpCas9	negative selection	11076063
33707025	33707048	15	-	28162770	P31FUJ	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	0.33317719293920467	[101]	[150]	3	hSpCas9	negative selection	11076064
33821561	33821584	15	+	28162770	P31FUJ	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	0.38924961504199773	[255]	[393]	4	hSpCas9	negative selection	11076065
33473469	33473492	15	+	28162770	P31FUJ	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	1.339776571850945	[38]	[115]	9	hSpCas9	negative selection	11076066
33473517	33473540	15	+	28162770	P31FUJ	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	-0.29274474487066066	[343]	[329]	-3	hSpCas9	negative selection	11076067
33503715	33503738	15	+	28162770	P31FUJ	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.7434416723330132	[397]	[782]	8	hSpCas9	negative selection	11076068
33603283	33603306	15	+	28162770	OCIAML5	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-5.487655144655121	[173]	[6]	-9	hSpCas9	negative selection	11245425
33530586	33530609	15	+	28162770	OCIAML5	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	0.5387233821681696	[89]	[235]	5	hSpCas9	negative selection	11245426
33662517	33662540	15	-	28162770	OCIAML5	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-1.5807645490466025	[57]	[34]	-7	hSpCas9	negative selection	11245427
33662834	33662857	15	+	28162770	OCIAML5	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	0.14793342913600327	[0]	[1]	1	hSpCas9	negative selection	11245428
33700977	33701000	15	-	28162770	OCIAML5	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	0.7328959298571593	[22]	[68]	6	hSpCas9	negative selection	11245429
33707025	33707048	15	-	28162770	OCIAML5	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	-1.6792299740017813	[54]	[30]	-7	hSpCas9	negative selection	11245430
33821561	33821584	15	+	28162770	OCIAML5	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	0.4449151668931346	[139]	[343]	4	hSpCas9	negative selection	11245431
33473469	33473492	15	+	28162770	OCIAML5	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	-1.7726321033695922	[52]	[27]	-7	hSpCas9	negative selection	11245432
33473517	33473540	15	+	28162770	OCIAML5	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	0.9878930166255349	[99]	[357]	8	hSpCas9	negative selection	11245433
33503715	33503738	15	+	28162770	OCIAML5	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.8986121909583908	[177]	[598]	7	hSpCas9	negative selection	11245434
33603283	33603306	15	+	28162770	EOL1	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-3.4300689420230026	[490]	[23]	-9	hSpCas9	negative selection	11414791
33530586	33530609	15	+	28162770	EOL1	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	-0.19744275280807577	[147]	[67]	-1	hSpCas9	negative selection	11414792
33662517	33662540	15	-	28162770	EOL1	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-4.42712766671088	[244]	[5]	-9	hSpCas9	negative selection	11414793
33662834	33662857	15	+	28162770	EOL1	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	-0.35556014762220123	[16]	[6]	-3	hSpCas9	negative selection	11414794
33700977	33701000	15	-	28162770	EOL1	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	1.32664621514188	[83]	[110]	9	hSpCas9	negative selection	11414795
33707025	33707048	15	-	28162770	EOL1	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	-0.2824146091963074	[216]	[93]	-2	hSpCas9	negative selection	11414796
33821561	33821584	15	+	28162770	EOL1	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	0.09076472423528534	[302]	[169]	0	hSpCas9	negative selection	11414797
33473469	33473492	15	+	28162770	EOL1	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.9995098292517565	[74]	[78]	8	hSpCas9	negative selection	11414798
33473517	33473540	15	+	28162770	EOL1	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	-0.7081904537200353	[306]	[98]	-5	hSpCas9	negative selection	11414799
33503715	33503738	15	+	28162770	EOL1	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.5820922744265908	[406]	[320]	5	hSpCas9	negative selection	11414800
33603283	33603306	15	+	28162770	MOLM13	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-4.094353042676493	[377]	[15]	-9	hSpCas9	negative selection	11584157
33530586	33530609	15	+	28162770	MOLM13	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	-1.0430725377328005	[227]	[79]	-5	hSpCas9	negative selection	11584158
33662517	33662540	15	-	28162770	MOLM13	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-3.854038713342783	[179]	[8]	-9	hSpCas9	negative selection	11584159
33662834	33662857	15	+	28162770	MOLM13	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	-4.232550336596514	[25]	[0]	-9	hSpCas9	negative selection	11584160
33700977	33701000	15	-	28162770	MOLM13	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	1.233424127907556	[59]	[101]	8	hSpCas9	negative selection	11584161
33707025	33707048	15	-	28162770	MOLM13	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	-0.5949983244108115	[210]	[100]	-3	hSpCas9	negative selection	11584162
33821561	33821584	15	+	28162770	MOLM13	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	0.05830631235784334	[351]	[264]	0	hSpCas9	negative selection	11584163
33473469	33473492	15	+	28162770	MOLM13	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.37825216905990255	[82]	[77]	2	hSpCas9	negative selection	11584164
33473517	33473540	15	+	28162770	MOLM13	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	-0.06951788951678084	[372]	[256]	0	hSpCas9	negative selection	11584165
33503715	33503738	15	+	28162770	MOLM13	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.11353980896483906	[449]	[351]	0	hSpCas9	negative selection	11584166
33603283	33603306	15	+	28162770	HEL	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-4.153532590928231	[388]	[13]	-9	hSpCas9	negative selection	11753523
33530586	33530609	15	+	28162770	HEL	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	1.0042469348624057	[150]	[193]	8	hSpCas9	negative selection	11753524
33662517	33662540	15	-	28162770	HEL	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-5.33454109149956	[125]	[1]	-9	hSpCas9	negative selection	11753525
33662834	33662857	15	+	28162770	HEL	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	-4.1646160900572475	[27]	[0]	-9	hSpCas9	negative selection	11753526
33700977	33701000	15	-	28162770	HEL	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	0.7271310192907293	[82]	[87]	6	hSpCas9	negative selection	11753527
33707025	33707048	15	-	28162770	HEL	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	0.7201433356859634	[126]	[133]	6	hSpCas9	negative selection	11753528
33821561	33821584	15	+	28162770	HEL	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	-0.7576021560717849	[292]	[110]	-5	hSpCas9	negative selection	11753529
33473469	33473492	15	+	28162770	HEL	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	1.03130411991801	[54]	[71]	8	hSpCas9	negative selection	11753530
33473517	33473540	15	+	28162770	HEL	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	0.2926058558538713	[296]	[232]	2	hSpCas9	negative selection	11753531
33503715	33503738	15	+	28162770	HEL	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.10217045063765418	[351]	[241]	0	hSpCas9	negative selection	11753532
33603283	33603306	15	+	28162770	MV411	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-4.240848930526707	[201]	[8]	-9	hSpCas9	negative selection	11922889
33530586	33530609	15	+	28162770	MV411	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	1.4006838110784572	[115]	[257]	9	hSpCas9	negative selection	11922890
33662517	33662540	15	-	28162770	MV411	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-3.222047732518445	[143]	[12]	-9	hSpCas9	negative selection	11922891
33662834	33662857	15	+	28162770	MV411	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	-3.5599173712748287	[13]	[0]	-9	hSpCas9	negative selection	11922892
33700977	33701000	15	-	28162770	MV411	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	0.10803449411735899	[75]	[68]	0	hSpCas9	negative selection	11922893
33707025	33707048	15	-	28162770	MV411	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	-1.0641485998831282	[138]	[55]	-6	hSpCas9	negative selection	11922894
33821561	33821584	15	+	28162770	MV411	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	0.5997392947136563	[187]	[239]	5	hSpCas9	negative selection	11922895
33473469	33473492	15	+	28162770	MV411	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.689955786483726	[38]	[52]	6	hSpCas9	negative selection	11922896
33473517	33473540	15	+	28162770	MV411	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	0.14002460836179587	[222]	[206]	1	hSpCas9	negative selection	11922897
33503715	33503738	15	+	28162770	MV411	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.046944611017694204	[315]	[274]	0	hSpCas9	negative selection	11922898
33603283	33603306	15	+	28162770	MONOMAC1	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-6.580741139533606	[166]	[1]	-9	hSpCas9	negative selection	12092255
33530586	33530609	15	+	28162770	MONOMAC1	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	0.7712542932131083	[91]	[179]	7	hSpCas9	negative selection	12092256
33662517	33662540	15	-	28162770	MONOMAC1	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-4.350842183138589	[88]	[4]	-9	hSpCas9	negative selection	12092257
33662834	33662857	15	+	28162770	MONOMAC1	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	-0.5189649419469164	[4]	[3]	-4	hSpCas9	negative selection	12092258
33700977	33701000	15	-	28162770	MONOMAC1	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	0.9769925527154953	[38]	[87]	8	hSpCas9	negative selection	12092259
33707025	33707048	15	-	28162770	MONOMAC1	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	0.1910336046190207	[80]	[105]	2	hSpCas9	negative selection	12092260
33821561	33821584	15	+	28162770	MONOMAC1	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	-0.316335775431898	[188]	[173]	-3	hSpCas9	negative selection	12092261
33473469	33473492	15	+	28162770	MONOMAC1	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.4619262351053792	[18]	[29]	4	hSpCas9	negative selection	12092262
33473517	33473540	15	+	28162770	MONOMAC1	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	0.6853591866282163	[197]	[364]	6	hSpCas9	negative selection	12092263
33503715	33503738	15	+	28162770	MONOMAC1	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.20592781991871512	[179]	[237]	2	hSpCas9	negative selection	12092264
33603283	33603306	15	+	28162770	OCIAML2	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-3.923142029939668	[51]	[18]	-9	hSpCas9	negative selection	12261621
33530586	33530609	15	+	28162770	OCIAML2	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	1.21920179333295	[20]	[270]	9	hSpCas9	negative selection	12261622
33662517	33662540	15	-	28162770	OCIAML2	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-2.300704823799849	[23]	[26]	-8	hSpCas9	negative selection	12261623
33662834	33662857	15	+	28162770	OCIAML2	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	-4.277984747299765	[6]	[1]	-9	hSpCas9	negative selection	12261624
33700977	33701000	15	-	28162770	OCIAML2	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	0.36587144247495906	[13]	[99]	3	hSpCas9	negative selection	12261625
33707025	33707048	15	-	28162770	OCIAML2	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	0.13423223291669983	[23]	[145]	1	hSpCas9	negative selection	12261626
33821561	33821584	15	+	28162770	OCIAML2	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	-0.16764329400825903	[45]	[226]	-1	hSpCas9	negative selection	12261627
33473469	33473492	15	+	28162770	OCIAML2	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	0.2949049211208159	[4]	[33]	3	hSpCas9	negative selection	12261628
33473517	33473540	15	+	28162770	OCIAML2	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	-0.4532825816782643	[61]	[250]	-4	hSpCas9	negative selection	12261629
33503715	33503738	15	+	28162770	OCIAML2	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.8726267790857132	[46]	[476]	8	hSpCas9	negative selection	12261630
33603283	33603306	15	+	28162770	OCIAML3	viability	GGAGGTGGAGAAGGATGGGGAGG	RYR3	ENSG00000198838	-4.8951771750447275	[68]	[6]	-9	hSpCas9	negative selection	12430987
33530586	33530609	15	+	28162770	OCIAML3	viability	CCACAGGCAGCACAAGGAGGTGG	RYR3	ENSG00000198838	1.1284583841469282	[34]	[230]	8	hSpCas9	negative selection	12430988
33662517	33662540	15	-	28162770	OCIAML3	viability	GGGGTGGAGAACCTGAACCCGGG	RYR3	ENSG00000198838	-2.371615218987715	[35]	[20]	-9	hSpCas9	negative selection	12430989
33662834	33662857	15	+	28162770	OCIAML3	viability	GGAGGAAGTGACCCAGGTGGAGG	RYR3	ENSG00000198838	1.4934552009261766	[1]	[16]	9	hSpCas9	negative selection	12430990
33700977	33701000	15	-	28162770	OCIAML3	viability	GGATCCCCTCATCGACGGGGAGG	RYR3	ENSG00000198838	-0.5565329349055002	[18]	[38]	-4	hSpCas9	negative selection	12430991
33707025	33707048	15	-	28162770	OCIAML3	viability	GAAGACAGCAAACCTCAGGAAGG	RYR3	ENSG00000198838	0.15493059550811905	[35]	[120]	1	hSpCas9	negative selection	12430992
33821561	33821584	15	+	28162770	OCIAML3	viability	GGGATCGCCATTCTGAACGGAGG	RYR3	ENSG00000198838	-0.4289483940536667	[65]	[147]	-3	hSpCas9	negative selection	12430993
33473469	33473492	15	+	28162770	OCIAML3	viability	GAAGTTCTGCCTGGCAGCCGAGG	RYR3	ENSG00000198838	-0.5521874646295359	[16]	[34]	-4	hSpCas9	negative selection	12430994
33473517	33473540	15	+	28162770	OCIAML3	viability	GGAACCCACTTCAGAAGCCAAGG	RYR3	ENSG00000198838	0.1030652267185303	[65]	[213]	1	hSpCas9	negative selection	12430995
33503715	33503738	15	+	28162770	OCIAML3	viability	ACAGGTGAAAATGGCGGCGAAGG	RYR3	ENSG00000198838	0.0018431765397292077	[87]	[265]	0	hSpCas9	negative selection	12430996