Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 23411
• Symbol: SIRT1
• Description: sirtuin 1

DataSource: http://genomecrispr.dkfz.de/#!/results/SIRT1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
67912707	67912730	10	-	26472758	Jiyoye	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-1.575546627062291	[82]	[20]	-7	hSpCas9	negative selection	147031
67912518	67912541	10	-	26472758	Jiyoye	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	-0.2913821510572425	[382]	[235]	-2	hSpCas9	negative selection	147032
67912752	67912775	10	-	26472758	Jiyoye	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	0.11672551809167908	[169]	[138]	0	hSpCas9	negative selection	147033
67906835	67906858	10	+	26472758	Jiyoye	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	0.10600584678530867	[68]	[55]	0	hSpCas9	negative selection	147034
67909390	67909413	10	-	26472758	Jiyoye	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-0.5746772717838674	[78]	[39]	-4	hSpCas9	negative selection	147035
67912979	67913002	10	+	26472758	Jiyoye	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	0.2257285101683415	[329]	[290]	1	hSpCas9	negative selection	147036
67906876	67906899	10	+	26472758	Jiyoye	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.04276395529699753	[111]	[86]	0	hSpCas9	negative selection	147037
67913002	67913025	10	+	26472758	Jiyoye	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	0.4071753815058734	[325]	[325]	3	hSpCas9	negative selection	147038
67906888	67906911	10	+	26472758	Jiyoye	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	-0.3077332917871356	[237]	[144]	-2	hSpCas9	negative selection	147039
67909262	67909285	10	-	26472758	Jiyoye	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	1.0327798667243757	[34]	[53]	6	hSpCas9	negative selection	147040
67912707	67912730	10	-	26472758	KBM7	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-0.31053813460297097	[213,128]	[78,49]	-3	hSpCas9	negative selection	338149
67912518	67912541	10	-	26472758	KBM7	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.7696508945835159	[1099,1304]	[853,1086]	8	hSpCas9	negative selection	338150
67912752	67912775	10	-	26472758	KBM7	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	-0.7974809611746265	[734,571]	[167,181]	-6	hSpCas9	negative selection	338151
67906835	67906858	10	+	26472758	KBM7	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-0.7598174958545102	[296,222]	[80,62]	-6	hSpCas9	negative selection	338152
67909390	67909413	10	-	26472758	KBM7	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-1.3437904363629656	[127,211]	[42,22]	-7	hSpCas9	negative selection	338153
67912979	67913002	10	+	26472758	KBM7	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	-0.42788678793674634	[1101,627]	[392,207]	-4	hSpCas9	negative selection	338154
67906876	67906899	10	+	26472758	KBM7	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.2068517864040307	[455,615]	[217,226]	-2	hSpCas9	negative selection	338155
67913002	67913025	10	+	26472758	KBM7	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	-0.08906541224063602	[1280,1429]	[709,511]	-1	hSpCas9	negative selection	338156
67906888	67906911	10	+	26472758	KBM7	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.2622407516433136	[857,710]	[528,360]	2	hSpCas9	negative selection	338157
67909262	67909285	10	-	26472758	KBM7	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	0.088979943303377	[228,337]	[130,157]	0	hSpCas9	negative selection	338158
67912707	67912730	10	-	26472758	Raji	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	0.5339166734902728	[124]	[41]	5	hSpCas9	negative selection	529267
67912518	67912541	10	-	26472758	Raji	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	-0.15474664289008033	[637]	[132]	-1	hSpCas9	negative selection	529268
67912752	67912775	10	-	26472758	Raji	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	0.29475367127532104	[273]	[77]	2	hSpCas9	negative selection	529269
67906835	67906858	10	+	26472758	Raji	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	0.29180810651102695	[87]	[24]	2	hSpCas9	negative selection	529270
67909390	67909413	10	-	26472758	Raji	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-0.29471490819774626	[73]	[13]	-2	hSpCas9	negative selection	529271
67912979	67913002	10	+	26472758	Raji	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	-0.4161784206834134	[459]	[79]	-3	hSpCas9	negative selection	529272
67906876	67906899	10	+	26472758	Raji	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.11869884860143358	[253]	[63]	1	hSpCas9	negative selection	529273
67913002	67913025	10	+	26472758	Raji	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	0.39942136794650085	[672]	[205]	4	hSpCas9	negative selection	529274
67906888	67906911	10	+	26472758	Raji	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.17387894716050623	[423]	[110]	1	hSpCas9	negative selection	529275
67909262	67909285	10	-	26472758	Raji	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	0.6719973907029534	[118]	[43]	6	hSpCas9	negative selection	529276
67912707	67912730	10	-	26472758	K562	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-0.30101540886807165	[107]	[73]	-2	hSpCas9	negative selection	720385
67912518	67912541	10	-	26472758	K562	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.4857617275565227	[993]	[1174]	4	hSpCas9	negative selection	720386
67912752	67912775	10	-	26472758	K562	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	-0.46411845817324193	[468]	[286]	-3	hSpCas9	negative selection	720387
67906835	67906858	10	+	26472758	K562	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	0.20259855197181986	[174]	[169]	1	hSpCas9	negative selection	720388
67909390	67909413	10	-	26472758	K562	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-2.3828545779126737	[172]	[27]	-8	hSpCas9	negative selection	720389
67912979	67913002	10	+	26472758	K562	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	-0.5282555633387823	[708]	[414]	-3	hSpCas9	negative selection	720390
67906876	67906899	10	+	26472758	K562	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.0665501552310491	[458]	[369]	0	hSpCas9	negative selection	720391
67913002	67913025	10	+	26472758	K562	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	0.5297059403473683	[964]	[1175]	4	hSpCas9	negative selection	720392
67906888	67906911	10	+	26472758	K562	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	-0.12400782932080712	[669]	[518]	-1	hSpCas9	negative selection	720393
67909262	67909285	10	-	26472758	K562	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	-0.9185198434597587	[205]	[91]	-5	hSpCas9	negative selection	720394
67884712	67884735	10	+	26627737	DLD1	viability	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.5698517689502898	[897]	[224,234,119]	-5	hSpCas9	negative selection	775319
67884837	67884860	10	+	26627737	DLD1	viability	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	0.40492818132601505	[89]	[40,29,39]	4	hSpCas9	negative selection	775320
67891458	67891481	10	-	26627737	DLD1	viability	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-0.7360621675257228	[545]	[134,39,125]	-6	hSpCas9	negative selection	775321
67906876	67906899	10	+	26627737	DLD1	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.6228732382396651	[372]	[267,112,157]	6	hSpCas9	negative selection	775322
67912985	67913008	10	+	26627737	DLD1	viability	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.7074321795266939	[532]	[243,286,283]	7	hSpCas9	negative selection	775323
67916305	67916328	10	-	26627737	DLD1	viability	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	0.712585686436725	[321]	[162,85,231]	7	hSpCas9	negative selection	775324
67884712	67884735	10	+	26627737	GBM cells	viability after 5 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.1960826390500613	[407]	[216,164]	-3	hSpCas9	negative selection	857634
67884837	67884860	10	+	26627737	GBM cells	viability after 5 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-0.194195529505796	[79]	[32,41]	-3	hSpCas9	negative selection	857635
67891458	67891481	10	-	26627737	GBM cells	viability after 5 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-0.01830844932985611	[253]	[153,114]	0	hSpCas9	negative selection	857636
67906876	67906899	10	+	26627737	GBM cells	viability after 5 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.1526704671314686	[259]	[121,187]	2	hSpCas9	negative selection	857637
67912985	67913008	10	+	26627737	GBM cells	viability after 5 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.26197709905075167	[324]	[206,210]	4	hSpCas9	negative selection	857638
67916305	67916328	10	-	26627737	GBM cells	viability after 5 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.48750294645339054	[182]	[91,47]	-6	hSpCas9	negative selection	857639
67884712	67884735	10	+	26627737	GBM cells	viability after 13 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	0.035384856479368954	[407]	[238,216]	0	hSpCas9	negative selection	939949
67884837	67884860	10	+	26627737	GBM cells	viability after 13 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-2.409644711170162	[79]	[0,13]	-9	hSpCas9	negative selection	939950
67891458	67891481	10	-	26627737	GBM cells	viability after 13 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-0.12375571448237802	[253]	[131,121]	-1	hSpCas9	negative selection	939951
67906876	67906899	10	+	26627737	GBM cells	viability after 13 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.20414642207731742	[259]	[138,108]	-2	hSpCas9	negative selection	939952
67912985	67913008	10	+	26627737	GBM cells	viability after 13 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.6373484142299299	[324]	[297,254]	7	hSpCas9	negative selection	939953
67916305	67916328	10	-	26627737	GBM cells	viability after 13 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.7011213995311395	[182]	[70,52]	-7	hSpCas9	negative selection	939954
67884712	67884735	10	+	26627737	GBM cells	viability after 21 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.08184477321825101	[407]	[210,207]	0	hSpCas9	negative selection	1022264
67884837	67884860	10	+	26627737	GBM cells	viability after 21 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-1.9209233527363192	[79]	[11,10]	-8	hSpCas9	negative selection	1022265
67891458	67891481	10	-	26627737	GBM cells	viability after 21 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	0.08772721892775198	[253]	[154,138]	0	hSpCas9	negative selection	1022266
67906876	67906899	10	+	26627737	GBM cells	viability after 21 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.9446447636082808	[259]	[75,70]	-7	hSpCas9	negative selection	1022267
67912985	67913008	10	+	26627737	GBM cells	viability after 21 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.5132809246898979	[324]	[286,219]	5	hSpCas9	negative selection	1022268
67916305	67916328	10	-	26627737	GBM cells	viability after 21 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-2.5891307029456403	[182]	[15,16]	-9	hSpCas9	negative selection	1022269
67884712	67884735	10	+	26627737	RPE1	viability after 9 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-1.6369884769714822	[1422]	[137,149]	-8	hSpCas9	negative selection	1104579
67884837	67884860	10	+	26627737	RPE1	viability after 9 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	0.6177014116756441	[27]	[19,4]	4	hSpCas9	negative selection	1104580
67891458	67891481	10	-	26627737	RPE1	viability after 9 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-0.4388597219361067	[768]	[167,189]	-3	hSpCas9	negative selection	1104581
67906876	67906899	10	+	26627737	RPE1	viability after 9 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.08885910899769991	[660]	[232,144]	0	hSpCas9	negative selection	1104582
67912985	67913008	10	+	26627737	RPE1	viability after 9 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.2611758516879108	[520]	[122,288]	1	hSpCas9	negative selection	1104583
67916305	67916328	10	-	26627737	RPE1	viability after 9 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-1.2284991447446436	[964]	[124,133]	-7	hSpCas9	negative selection	1104584
67884712	67884735	10	+	26627737	RPE1	viability after 12 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-1.6204287105479716	[1422]	[169,75]	-8	hSpCas9	negative selection	1186894
67884837	67884860	10	+	26627737	RPE1	viability after 12 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	1.8813144097450571	[27]	[17,37]	8	hSpCas9	negative selection	1186895
67891458	67891481	10	-	26627737	RPE1	viability after 12 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-0.3065305172546089	[768]	[134,200]	-2	hSpCas9	negative selection	1186896
67906876	67906899	10	+	26627737	RPE1	viability after 12 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.28313525707679643	[660]	[75,219]	-2	hSpCas9	negative selection	1186897
67912985	67913008	10	+	26627737	RPE1	viability after 12 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.5281626776709647	[520]	[247,152]	3	hSpCas9	negative selection	1186898
67916305	67916328	10	-	26627737	RPE1	viability after 12 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.6333358280691422	[964]	[103,233]	-4	hSpCas9	negative selection	1186899
67884712	67884735	10	+	26627737	RPE1	viability after 15 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.9793302369288702	[1422]	[306,104]	-6	hSpCas9	negative selection	1269209
67884837	67884860	10	+	26627737	RPE1	viability after 15 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	2.1018567930646292	[27]	[33,33]	8	hSpCas9	negative selection	1269210
67891458	67891481	10	-	26627737	RPE1	viability after 15 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-1.095965359027744	[768]	[142,61]	-6	hSpCas9	negative selection	1269211
67906876	67906899	10	+	26627737	RPE1	viability after 15 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.09185032196003118	[660]	[211,186]	0	hSpCas9	negative selection	1269212
67912985	67913008	10	+	26627737	RPE1	viability after 15 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.3786618653865913	[520]	[128,251]	2	hSpCas9	negative selection	1269213
67916305	67916328	10	-	26627737	RPE1	viability after 15 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-1.4909074784144587	[964]	[33,157]	-7	hSpCas9	negative selection	1269214
67884712	67884735	10	+	26627737	RPE1	viability after 18 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-2.0707349395303987	[1422]	[15,171]	-8	hSpCas9	negative selection	1351524
67884837	67884860	10	+	26627737	RPE1	viability after 18 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	1.6834239930848471	[27]	[2,46]	8	hSpCas9	negative selection	1351525
67891458	67891481	10	-	26627737	RPE1	viability after 18 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-1.2539137022456808	[768]	[72,101]	-7	hSpCas9	negative selection	1351526
67906876	67906899	10	+	26627737	RPE1	viability after 18 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.07307162317486368	[660]	[127,213]	0	hSpCas9	negative selection	1351527
67912985	67913008	10	+	26627737	RPE1	viability after 18 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.9144804498796243	[520]	[250,279]	5	hSpCas9	negative selection	1351528
67916305	67916328	10	-	26627737	RPE1	viability after 18 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.5913934815384108	[964]	[109,239]	-4	hSpCas9	negative selection	1351529
67884712	67884735	10	+	26627737	HeLa	viability after 8 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.6288662766767088	[951]	[175,421,190]	-6	hSpCas9	negative selection	1433839
67884837	67884860	10	+	26627737	HeLa	viability after 8 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-1.2805278790968577	[75]	[41,4,0]	-8	hSpCas9	negative selection	1433840
67891458	67891481	10	-	26627737	HeLa	viability after 8 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-1.6445527436070893	[778]	[96,135,90]	-9	hSpCas9	negative selection	1433841
67906876	67906899	10	+	26627737	HeLa	viability after 8 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.19758172157267043	[393]	[86,93,371]	2	hSpCas9	negative selection	1433842
67912985	67913008	10	+	26627737	HeLa	viability after 8 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.5127150698625079	[631]	[418,416,349]	4	hSpCas9	negative selection	1433843
67916305	67916328	10	-	26627737	HeLa	viability after 8 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.758609865716333	[342]	[208,34,49]	-6	hSpCas9	negative selection	1433844
67884712	67884735	10	+	26627737	HeLa	viability after 12 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.44729626461601224	[951]	[117,445,279]	-4	hSpCas9	negative selection	1516154
67884837	67884860	10	+	26627737	HeLa	viability after 12 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-0.23475403526521843	[75]	[19,34,23]	-2	hSpCas9	negative selection	1516155
67891458	67891481	10	-	26627737	HeLa	viability after 12 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-2.2041589949283127	[778]	[191,23,1]	-9	hSpCas9	negative selection	1516156
67906876	67906899	10	+	26627737	HeLa	viability after 12 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.9560022473530956	[393]	[2,40,209]	-7	hSpCas9	negative selection	1516157
67912985	67913008	10	+	26627737	HeLa	viability after 12 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.3107454442241333	[631]	[382,187,416]	2	hSpCas9	negative selection	1516158
67916305	67916328	10	-	26627737	HeLa	viability after 12 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	0.11901263458362178	[342]	[179,64,226]	1	hSpCas9	negative selection	1516159
67884712	67884735	10	+	26627737	HeLa	viability after 15 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.8150273120440854	[951]	[165,257,238]	-6	hSpCas9	negative selection	1598469
67884837	67884860	10	+	26627737	HeLa	viability after 15 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-1.7013830421625173	[75]	[0,25,0]	-9	hSpCas9	negative selection	1598470
67891458	67891481	10	-	26627737	HeLa	viability after 15 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-1.3744924026782357	[778]	[137,54,177]	-8	hSpCas9	negative selection	1598471
67906876	67906899	10	+	26627737	HeLa	viability after 15 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.04128990296509073	[393]	[199,89,207]	0	hSpCas9	negative selection	1598472
67912985	67913008	10	+	26627737	HeLa	viability after 15 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.6174478582631361	[631]	[309,374,508]	5	hSpCas9	negative selection	1598473
67916305	67916328	10	-	26627737	HeLa	viability after 15 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.673736257333164	[342]	[72,135,50]	-5	hSpCas9	negative selection	1598474
67884712	67884735	10	+	26627737	HeLa	viability after 18 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.801239073584538	[951]	[111,217,238]	-6	hSpCas9	negative selection	1680784
67884837	67884860	10	+	26627737	HeLa	viability after 18 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-1.7087219071671789	[75]	[0,20,0]	-9	hSpCas9	negative selection	1680785
67891458	67891481	10	-	26627737	HeLa	viability after 18 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-1.3613736700027708	[778]	[95,43,177]	-8	hSpCas9	negative selection	1680786
67906876	67906899	10	+	26627737	HeLa	viability after 18 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.03312729956324897	[393]	[131,74,207]	0	hSpCas9	negative selection	1680787
67912985	67913008	10	+	26627737	HeLa	viability after 18 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.5889691237445692	[631]	[194,307,508]	5	hSpCas9	negative selection	1680788
67916305	67916328	10	-	26627737	HeLa	viability after 18 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.6309102280213137	[342]	[56,108,50]	-5	hSpCas9	negative selection	1680789
67884712	67884735	10	+	26627737	HCT116	viability after 6 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	1.0036365988567544	[1628]	[1012,237]	5	hSpCas9	negative selection	1763099
67884837	67884860	10	+	26627737	HCT116	viability after 6 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	0.8837482347040264	[184]	[72,42]	5	hSpCas9	negative selection	1763100
67891458	67891481	10	-	26627737	HCT116	viability after 6 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-0.46869336709249704	[628]	[142,31]	-3	hSpCas9	negative selection	1763101
67906876	67906899	10	+	26627737	HCT116	viability after 6 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.018229653483903485	[1004]	[233,112]	0	hSpCas9	negative selection	1763102
67912985	67913008	10	+	26627737	HCT116	viability after 6 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.028422320479083718	[696]	[123,104]	0	hSpCas9	negative selection	1763103
67916305	67916328	10	-	26627737	HCT116	viability after 6 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	1.324961921209602	[285]	[276,21]	7	hSpCas9	negative selection	1763104
67884712	67884735	10	+	26627737	HCT116	viability after 8 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.08870622832446484	[536]	[261,254,316]	-1	hSpCas9	negative selection	1845414
67884837	67884860	10	+	26627737	HCT116	viability after 8 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	0.4885051193907368	[63]	[37,41,67]	5	hSpCas9	negative selection	1845415
67891458	67891481	10	-	26627737	HCT116	viability after 8 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	0.9231817560502511	[118]	[88,125,156]	8	hSpCas9	negative selection	1845416
67906876	67906899	10	+	26627737	HCT116	viability after 8 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.4416725734594291	[469]	[81,125,77]	-9	hSpCas9	negative selection	1845417
67912985	67913008	10	+	26627737	HCT116	viability after 8 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.5076288680874819	[362]	[291,172,386]	5	hSpCas9	negative selection	1845418
67916305	67916328	10	-	26627737	HCT116	viability after 8 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.6141059140718911	[249]	[140,46,82]	-6	hSpCas9	negative selection	1845419
67884712	67884735	10	+	26627737	HCT116	viability after 9 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.7436135096711327	[1628]	[299,227]	-5	hSpCas9	negative selection	1927729
67884837	67884860	10	+	26627737	HCT116	viability after 9 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	0.5737227113762611	[184]	[120,35]	4	hSpCas9	negative selection	1927730
67891458	67891481	10	-	26627737	HCT116	viability after 9 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	0.22417533971605952	[628]	[36,321]	1	hSpCas9	negative selection	1927731
67906876	67906899	10	+	26627737	HCT116	viability after 9 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.7478404380809721	[1004]	[186,658]	5	hSpCas9	negative selection	1927732
67912985	67913008	10	+	26627737	HCT116	viability after 9 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.6246101470024823	[696]	[420,180]	4	hSpCas9	negative selection	1927733
67916305	67916328	10	-	26627737	HCT116	viability after 9 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	1.365255723052116	[285]	[327,92]	8	hSpCas9	negative selection	1927734
67884712	67884735	10	+	26627737	HCT116	viability after 12 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.33799629787650853	[536]	[261,206,196]	-4	hSpCas9	negative selection	2010044
67884837	67884860	10	+	26627737	HCT116	viability after 12 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	0.7051378693857571	[63]	[41,28,93]	6	hSpCas9	negative selection	2010045
67891458	67891481	10	-	26627737	HCT116	viability after 12 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	0.9343018433988408	[118]	[56,118,187]	7	hSpCas9	negative selection	2010046
67906876	67906899	10	+	26627737	HCT116	viability after 12 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.0083123682031288	[469]	[133,106,125]	-8	hSpCas9	negative selection	2010047
67912985	67913008	10	+	26627737	HCT116	viability after 12 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.1400217367681868	[362]	[168,199,264]	1	hSpCas9	negative selection	2010048
67916305	67916328	10	-	26627737	HCT116	viability after 12 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.3538417743459733	[249]	[55,80,174]	-4	hSpCas9	negative selection	2010049
67884712	67884735	10	+	26627737	HCT116	viability after 15 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.28665269435930907	[536]	[311,227,225]	-3	hSpCas9	negative selection	2092359
67884837	67884860	10	+	26627737	HCT116	viability after 15 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	0.023065424438239557	[63]	[50,49,12]	0	hSpCas9	negative selection	2092360
67891458	67891481	10	-	26627737	HCT116	viability after 15 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	1.1945480010745717	[118]	[212,95,166]	8	hSpCas9	negative selection	2092361
67906876	67906899	10	+	26627737	HCT116	viability after 15 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.8653543428778923	[469]	[79,71,70]	-9	hSpCas9	negative selection	2092362
67912985	67913008	10	+	26627737	HCT116	viability after 15 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.21864206120846214	[362]	[290,229,212]	2	hSpCas9	negative selection	2092363
67916305	67916328	10	-	26627737	HCT116	viability after 15 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.7750267857302001	[249]	[64,66,116]	-7	hSpCas9	negative selection	2092364
67884712	67884735	10	+	26627737	HCT116	viability after 18 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	0.22175892234415917	[536]	[335,256,318]	2	hSpCas9	negative selection	2174674
67884837	67884860	10	+	26627737	HCT116	viability after 18 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	0.5357653611700799	[63]	[71,29,32]	4	hSpCas9	negative selection	2174675
67891458	67891481	10	-	26627737	HCT116	viability after 18 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	0.8048047856867311	[118]	[31,72,202]	6	hSpCas9	negative selection	2174676
67906876	67906899	10	+	26627737	HCT116	viability after 18 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.4646006245723928	[469]	[52,119,70]	-8	hSpCas9	negative selection	2174677
67912985	67913008	10	+	26627737	HCT116	viability after 18 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.2790660969021194	[362]	[253,168,218]	2	hSpCas9	negative selection	2174678
67916305	67916328	10	-	26627737	HCT116	viability after 18 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.8151648072378658	[249]	[30,41,137]	-6	hSpCas9	negative selection	2174679
67891528	67891551	10	-	24336569	HL60	viability	GCAAACTTGAAGAATGGTCTTGG	SIRT1	ENSG00000096717	0.8452571466819893	[630]	[2398]	7	hSpCas9	negative selection	2295143
67891534	67891557	10	-	24336569	HL60	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	-0.36035245766352725	[548]	[904]	-3	hSpCas9	negative selection	2295144
67906781	67906804	10	+	24336569	HL60	viability	TTGATACAGGAAATATATCCTGG	SIRT1	ENSG00000096717	-0.5103541862544864	[592]	[880]	-4	hSpCas9	negative selection	2295145
67906799	67906822	10	-	24336569	HL60	viability	AGAGATGGCTGGAATTGTCCAGG	SIRT1	ENSG00000096717	-0.9118590936518837	[1001]	[1126]	-7	hSpCas9	negative selection	2295146
67906810	67906833	10	-	24336569	HL60	viability	ATTTGTGACAGAGAGATGGCTGG	SIRT1	ENSG00000096717	0.6156087664137972	[1022]	[3316]	5	hSpCas9	negative selection	2295147
67906831	67906854	10	+	24336569	HL60	viability	ATTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	0.12721438625567705	[754]	[1744]	1	hSpCas9	negative selection	2295148
67906876	67906899	10	+	24336569	HL60	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.0844572449408798	[964]	[962]	-7	hSpCas9	negative selection	2295149
67906882	67906905	10	+	24336569	HL60	viability	GAACATAGACACGCTGGAACAGG	SIRT1	ENSG00000096717	-0.08435237995372291	[249]	[498]	0	hSpCas9	negative selection	2295150
67906888	67906911	10	+	24336569	HL60	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	-1.2488424199608623	[565]	[503]	-8	hSpCas9	negative selection	2295151
67906899	67906922	10	+	24336569	HL60	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.2115246411932692	[231]	[423]	-2	hSpCas9	negative selection	2295152
67891528	67891551	10	-	24336569	KBM7	viability	GCAAACTTGAAGAATGGTCTTGG	SIRT1	ENSG00000096717	0.5044290806407277	[595]	[2305]	4	hSpCas9	negative selection	2362320
67891534	67891557	10	-	24336569	KBM7	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.0906024039599314	[396]	[1152]	0	hSpCas9	negative selection	2362321
67906781	67906804	10	+	24336569	KBM7	viability	TTGATACAGGAAATATATCCTGG	SIRT1	ENSG00000096717	0.019386094773822367	[381]	[1055]	0	hSpCas9	negative selection	2362322
67906799	67906822	10	-	24336569	KBM7	viability	AGAGATGGCTGGAATTGTCCAGG	SIRT1	ENSG00000096717	-0.8642702146802401	[581]	[871]	-6	hSpCas9	negative selection	2362323
67906810	67906833	10	-	24336569	KBM7	viability	ATTTGTGACAGAGAGATGGCTGG	SIRT1	ENSG00000096717	-0.6172397986427247	[1022]	[1818]	-5	hSpCas9	negative selection	2362324
67906831	67906854	10	+	24336569	KBM7	viability	ATTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	0.44557359826395104	[815]	[3030]	4	hSpCas9	negative selection	2362325
67906876	67906899	10	+	24336569	KBM7	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.9750106990675472	[804]	[1116]	-6	hSpCas9	negative selection	2362326
67906882	67906905	10	+	24336569	KBM7	viability	GAACATAGACACGCTGGAACAGG	SIRT1	ENSG00000096717	-0.32590063996063023	[249]	[543]	-3	hSpCas9	negative selection	2362327
67906888	67906911	10	+	24336569	KBM7	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	-0.36443796124863675	[294]	[624]	-3	hSpCas9	negative selection	2362328
67906899	67906922	10	+	24336569	KBM7	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-1.556189694480552	[261]	[242]	-8	hSpCas9	negative selection	2362329
67885039	67885062	10	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCTCCCGAGATGGGCCCTGCAGG	SIRT1	ENSG00000096717	0.24312712977654605	[268,160]	[35,76]	1	dCas9-VP64	positive selection	2400735
67885016	67885039	10	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGGGAAGGAGACAATGGGCCGGG	SIRT1	ENSG00000096717	1.8152743515635184	[8,8]	[12,0]	6	dCas9-VP64	positive selection	2400736
67885061	67885084	10	-	25494202	A375	resistance to PLX-4720 (puromycin)	TACAAGTTGTCGGCCAGCGGTGG	SIRT1	ENSG00000096717	3.1384032199333247	[13,2]	[11,20]	8	dCas9-VP64	positive selection	2400737
67885039	67885062	10	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCTCCCGAGATGGGCCCTGCAGG	SIRT1	ENSG00000096717	0.6279646330766548	[43,122]	[37,44]	4	dCas9-VP64	positive selection	2495990
67885016	67885039	10	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGGGAAGGAGACAATGGGCCGGG	SIRT1	ENSG00000096717	1.1247047836185928	[39,28]	[23,24]	7	dCas9-VP64	positive selection	2495991
67885061	67885084	10	-	25494202	A375	resistance to PLX-4720 (zeocin)	TACAAGTTGTCGGCCAGCGGTGG	SIRT1	ENSG00000096717	0.3673639653093317	[10,18]	[8,2]	3	dCas9-VP64	positive selection	2495992
67884813	67884836	10	+	27260157	DLD1	viability	AGCCGCTCCGCAAGAGGCCGCGG	SIRT1	ENSG00000096717	0.0865957619530983	[]	[]	3	hSpCas9	negative selection	2574312
67885061	67885084	10	-	27260157	DLD1	viability	TACAAGTTGTCGGCCAGCGGTGG	SIRT1	ENSG00000096717	-0.155741937957096	[]	[]	-1	hSpCas9	negative selection	2578219
67906876	67906899	10	+	27260157	DLD1	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.456719700202278	[]	[]	-4	hSpCas9	negative selection	2578488
67884830	67884853	10	-	27260157	DLD1	viability	AGGCCGGGACCATCTCTCCGCGG	SIRT1	ENSG00000096717	0.651775053803643	[]	[]	8	hSpCas9	negative selection	2578892
67906799	67906822	10	-	27260157	DLD1	viability	AGAGATGGCTGGAATTGTCCAGG	SIRT1	ENSG00000096717	0.293190755191276	[]	[]	4	hSpCas9	negative selection	2581044
67906882	67906905	10	+	27260157	DLD1	viability	GAACATAGACACGCTGGAACAGG	SIRT1	ENSG00000096717	-0.0795738058931478	[]	[]	0	hSpCas9	negative selection	2581997
67884780	67884803	10	-	27260157	DLD1	viability	GGACGACGCGGCCTCCCTGTCGG	SIRT1	ENSG00000096717	-1.00193879480673	[]	[]	-7	hSpCas9	negative selection	2585177
67884837	67884860	10	+	27260157	DLD1	viability	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	0.763677914373812	[]	[]	8	hSpCas9	negative selection	2586537
67891528	67891551	10	-	27260157	DLD1	viability	GCAAACTTGAAGAATGGTCTTGG	SIRT1	ENSG00000096717	-0.335488758598946	[]	[]	-3	hSpCas9	negative selection	2605806
67885035	67885058	10	+	27260157	DLD1	viability	CGGGCCTGCAGGGCCCATCTCGG	SIRT1	ENSG00000096717	-0.404540699547329	[]	[]	-3	hSpCas9	negative selection	2605840
67906831	67906854	10	+	27260157	DLD1	viability	ATTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	-0.247893970851037	[]	[]	-2	hSpCas9	negative selection	2607334
67884885	67884908	10	-	27260157	DLD1	viability	CGCCGGCACCTCACGCTCTGGGG	SIRT1	ENSG00000096717	0.0354890582137599	[]	[]	0	hSpCas9	negative selection	2610314
67885199	67885222	10	-	27260157	DLD1	viability	CTCAGGCCAGTAGGAGCCCGGGG	SIRT1	ENSG00000096717	-0.345800530262761	[]	[]	-3	hSpCas9	negative selection	2611974
67891534	67891557	10	-	27260157	DLD1	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.377180227902614	[]	[]	4	hSpCas9	negative selection	2612125
67906781	67906804	10	+	27260157	DLD1	viability	TTGATACAGGAAATATATCCTGG	SIRT1	ENSG00000096717	-0.629507860390283	[]	[]	-5	hSpCas9	negative selection	2612903
67906899	67906922	10	+	27260157	DLD1	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.925066854245873	[]	[]	-6	hSpCas9	negative selection	2618243
67906810	67906833	10	-	27260157	DLD1	viability	ATTTGTGACAGAGAGATGGCTGG	SIRT1	ENSG00000096717	1.11646148844967	[]	[]	9	hSpCas9	negative selection	2620309
67906888	67906911	10	+	27260157	DLD1	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.0174371467948076	[]	[]	0	hSpCas9	negative selection	2623206
67884807	67884830	10	-	27260157	DLD1	viability	CCTCTTGCGGAGCGGCTCCCCGG	SIRT1	ENSG00000096717	-1.30716171673656	[]	[]	-7	hSpCas9	negative selection	2644163
67884813	67884836	10	+	27260157	HT1080	viability	AGCCGCTCCGCAAGAGGCCGCGG	SIRT1	ENSG00000096717	0.294948319294611	[]	[]	2	hSpCas9	negative selection	2650442
67885061	67885084	10	-	27260157	HT1080	viability	TACAAGTTGTCGGCCAGCGGTGG	SIRT1	ENSG00000096717	-0.669215885110255	[]	[]	-8	hSpCas9	negative selection	2654349
67906876	67906899	10	+	27260157	HT1080	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.179203255872792	[]	[]	0	hSpCas9	negative selection	2654618
67884830	67884853	10	-	27260157	HT1080	viability	AGGCCGGGACCATCTCTCCGCGG	SIRT1	ENSG00000096717	0.937698692977375	[]	[]	7	hSpCas9	negative selection	2655022
67906799	67906822	10	-	27260157	HT1080	viability	AGAGATGGCTGGAATTGTCCAGG	SIRT1	ENSG00000096717	0.702471054855943	[]	[]	6	hSpCas9	negative selection	2657174
67906882	67906905	10	+	27260157	HT1080	viability	GAACATAGACACGCTGGAACAGG	SIRT1	ENSG00000096717	0.342852389283621	[]	[]	3	hSpCas9	negative selection	2658127
67884780	67884803	10	-	27260157	HT1080	viability	GGACGACGCGGCCTCCCTGTCGG	SIRT1	ENSG00000096717	-0.433216076915488	[]	[]	-7	hSpCas9	negative selection	2661307
67884837	67884860	10	+	27260157	HT1080	viability	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	0.991583201528688	[]	[]	8	hSpCas9	negative selection	2662667
67891528	67891551	10	-	27260157	HT1080	viability	GCAAACTTGAAGAATGGTCTTGG	SIRT1	ENSG00000096717	0.622485850256571	[]	[]	5	hSpCas9	negative selection	2681936
67885035	67885058	10	+	27260157	HT1080	viability	CGGGCCTGCAGGGCCCATCTCGG	SIRT1	ENSG00000096717	-0.0581636999581838	[]	[]	0	hSpCas9	negative selection	2681970
67906831	67906854	10	+	27260157	HT1080	viability	ATTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	0.571625328070567	[]	[]	5	hSpCas9	negative selection	2683464
67884885	67884908	10	-	27260157	HT1080	viability	CGCCGGCACCTCACGCTCTGGGG	SIRT1	ENSG00000096717	-0.161518820361118	[]	[]	0	hSpCas9	negative selection	2686444
67885199	67885222	10	-	27260157	HT1080	viability	CTCAGGCCAGTAGGAGCCCGGGG	SIRT1	ENSG00000096717	-0.498845049614124	[]	[]	-7	hSpCas9	negative selection	2688104
67891534	67891557	10	-	27260157	HT1080	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.445090019837998	[]	[]	4	hSpCas9	negative selection	2688255
67906781	67906804	10	+	27260157	HT1080	viability	TTGATACAGGAAATATATCCTGG	SIRT1	ENSG00000096717	-2.05721269154827	[]	[]	-9	hSpCas9	negative selection	2689033
67906899	67906922	10	+	27260157	HT1080	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.312989448414245	[]	[]	-7	hSpCas9	negative selection	2694373
67906810	67906833	10	-	27260157	HT1080	viability	ATTTGTGACAGAGAGATGGCTGG	SIRT1	ENSG00000096717	0.789723103734793	[]	[]	7	hSpCas9	negative selection	2696439
67906888	67906911	10	+	27260157	HT1080	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	1.2052008933352	[]	[]	8	hSpCas9	negative selection	2699336
67884807	67884830	10	-	27260157	HT1080	viability	CCTCTTGCGGAGCGGCTCCCCGG	SIRT1	ENSG00000096717	-1.23765303226914	[]	[]	-9	hSpCas9	negative selection	2720293
67884813	67884836	10	+	27260157	MKN45	viability	AGCCGCTCCGCAAGAGGCCGCGG	SIRT1	ENSG00000096717	0.0759232912690141	[]	[]	0	hSpCas9	negative selection	2726572
67885061	67885084	10	-	27260157	MKN45	viability	TACAAGTTGTCGGCCAGCGGTGG	SIRT1	ENSG00000096717	-1.40070581872863	[]	[]	-8	hSpCas9	negative selection	2730479
67906876	67906899	10	+	27260157	MKN45	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.543059119230194	[]	[]	-6	hSpCas9	negative selection	2730748
67884830	67884853	10	-	27260157	MKN45	viability	AGGCCGGGACCATCTCTCCGCGG	SIRT1	ENSG00000096717	0.0298358807518582	[]	[]	0	hSpCas9	negative selection	2731152
67906799	67906822	10	-	27260157	MKN45	viability	AGAGATGGCTGGAATTGTCCAGG	SIRT1	ENSG00000096717	-0.258697974144605	[]	[]	-1	hSpCas9	negative selection	2733304
67906882	67906905	10	+	27260157	MKN45	viability	GAACATAGACACGCTGGAACAGG	SIRT1	ENSG00000096717	0.12809342102471	[]	[]	4	hSpCas9	negative selection	2734257
67884780	67884803	10	-	27260157	MKN45	viability	GGACGACGCGGCCTCCCTGTCGG	SIRT1	ENSG00000096717	-0.0460437003808267	[]	[]	0	hSpCas9	negative selection	2737437
67884837	67884860	10	+	27260157	MKN45	viability	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	1.08106730021875	[]	[]	8	hSpCas9	negative selection	2738797
67891528	67891551	10	-	27260157	MKN45	viability	GCAAACTTGAAGAATGGTCTTGG	SIRT1	ENSG00000096717	-0.129519498968458	[]	[]	0	hSpCas9	negative selection	2758066
67885035	67885058	10	+	27260157	MKN45	viability	CGGGCCTGCAGGGCCCATCTCGG	SIRT1	ENSG00000096717	-0.219828658750073	[]	[]	-1	hSpCas9	negative selection	2758100
67906831	67906854	10	+	27260157	MKN45	viability	ATTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	0.156675550399363	[]	[]	5	hSpCas9	negative selection	2759594
67884885	67884908	10	-	27260157	MKN45	viability	CGCCGGCACCTCACGCTCTGGGG	SIRT1	ENSG00000096717	-0.596218414989873	[]	[]	-6	hSpCas9	negative selection	2762574
67885199	67885222	10	-	27260157	MKN45	viability	CTCAGGCCAGTAGGAGCCCGGGG	SIRT1	ENSG00000096717	-0.231835429750714	[]	[]	-1	hSpCas9	negative selection	2764234
67891534	67891557	10	-	27260157	MKN45	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	1.00740314555432	[]	[]	8	hSpCas9	negative selection	2764385
67906781	67906804	10	+	27260157	MKN45	viability	TTGATACAGGAAATATATCCTGG	SIRT1	ENSG00000096717	-0.719019008613333	[]	[]	-7	hSpCas9	negative selection	2765163
67906899	67906922	10	+	27260157	MKN45	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.700421202209072	[]	[]	7	hSpCas9	negative selection	2770503
67906810	67906833	10	-	27260157	MKN45	viability	ATTTGTGACAGAGAGATGGCTGG	SIRT1	ENSG00000096717	0.564499290619019	[]	[]	7	hSpCas9	negative selection	2772569
67906888	67906911	10	+	27260157	MKN45	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	-0.728080755808537	[]	[]	-7	hSpCas9	negative selection	2775466
67884807	67884830	10	-	27260157	MKN45	viability	CCTCTTGCGGAGCGGCTCCCCGG	SIRT1	ENSG00000096717	0.472680069249021	[]	[]	6	hSpCas9	negative selection	2796423
67884813	67884836	10	+	27260157	RKO	viability	AGCCGCTCCGCAAGAGGCCGCGG	SIRT1	ENSG00000096717	-0.275498275374623	[]	[]	-1	hSpCas9	negative selection	2802702
67885061	67885084	10	-	27260157	RKO	viability	TACAAGTTGTCGGCCAGCGGTGG	SIRT1	ENSG00000096717	-0.360057129604936	[]	[]	-6	hSpCas9	negative selection	2806609
67906876	67906899	10	+	27260157	RKO	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.561240014092736	[]	[]	-7	hSpCas9	negative selection	2806878
67884830	67884853	10	-	27260157	RKO	viability	AGGCCGGGACCATCTCTCCGCGG	SIRT1	ENSG00000096717	0.480460036854666	[]	[]	2	hSpCas9	negative selection	2807282
67906799	67906822	10	-	27260157	RKO	viability	AGAGATGGCTGGAATTGTCCAGG	SIRT1	ENSG00000096717	0.775321968316658	[]	[]	8	hSpCas9	negative selection	2809434
67906882	67906905	10	+	27260157	RKO	viability	GAACATAGACACGCTGGAACAGG	SIRT1	ENSG00000096717	-0.179365385097676	[]	[]	-1	hSpCas9	negative selection	2810387
67884780	67884803	10	-	27260157	RKO	viability	GGACGACGCGGCCTCCCTGTCGG	SIRT1	ENSG00000096717	-0.946847692680276	[]	[]	-8	hSpCas9	negative selection	2813567
67884837	67884860	10	+	27260157	RKO	viability	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	0.31210743999651	[]	[]	1	hSpCas9	negative selection	2814927
67891528	67891551	10	-	27260157	RKO	viability	GCAAACTTGAAGAATGGTCTTGG	SIRT1	ENSG00000096717	1.08159689372171	[]	[]	9	hSpCas9	negative selection	2834196
67885035	67885058	10	+	27260157	RKO	viability	CGGGCCTGCAGGGCCCATCTCGG	SIRT1	ENSG00000096717	0.0736123755009451	[]	[]	0	hSpCas9	negative selection	2834230
67906831	67906854	10	+	27260157	RKO	viability	ATTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	0.290384832086363	[]	[]	1	hSpCas9	negative selection	2835724
67884885	67884908	10	-	27260157	RKO	viability	CGCCGGCACCTCACGCTCTGGGG	SIRT1	ENSG00000096717	-1.13340189510054	[]	[]	-8	hSpCas9	negative selection	2838704
67885199	67885222	10	-	27260157	RKO	viability	CTCAGGCCAGTAGGAGCCCGGGG	SIRT1	ENSG00000096717	-0.267282171059206	[]	[]	-1	hSpCas9	negative selection	2840364
67891534	67891557	10	-	27260157	RKO	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.873386943817664	[]	[]	8	hSpCas9	negative selection	2840515
67906781	67906804	10	+	27260157	RKO	viability	TTGATACAGGAAATATATCCTGG	SIRT1	ENSG00000096717	-0.646925345207848	[]	[]	-7	hSpCas9	negative selection	2841293
67906899	67906922	10	+	27260157	RKO	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.168180511344646	[]	[]	0	hSpCas9	negative selection	2846633
67906810	67906833	10	-	27260157	RKO	viability	ATTTGTGACAGAGAGATGGCTGG	SIRT1	ENSG00000096717	0.458148051176457	[]	[]	2	hSpCas9	negative selection	2848699
67906888	67906911	10	+	27260157	RKO	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.215200837104059	[]	[]	1	hSpCas9	negative selection	2851596
67884807	67884830	10	-	27260157	RKO	viability	CCTCTTGCGGAGCGGCTCCCCGG	SIRT1	ENSG00000096717	-0.969009965211248	[]	[]	-8	hSpCas9	negative selection	2872553
67884813	67884836	10	+	27260157	SF268	viability	AGCCGCTCCGCAAGAGGCCGCGG	SIRT1	ENSG00000096717	1.22595842980324	[]	[]	9	hSpCas9	negative selection	2878832
67885061	67885084	10	-	27260157	SF268	viability	TACAAGTTGTCGGCCAGCGGTGG	SIRT1	ENSG00000096717	-0.561831061876524	[]	[]	-4	hSpCas9	negative selection	2882739
67906876	67906899	10	+	27260157	SF268	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.649863860977019	[]	[]	-5	hSpCas9	negative selection	2883008
67884830	67884853	10	-	27260157	SF268	viability	AGGCCGGGACCATCTCTCCGCGG	SIRT1	ENSG00000096717	0.564171764162239	[]	[]	8	hSpCas9	negative selection	2883412
67906799	67906822	10	-	27260157	SF268	viability	AGAGATGGCTGGAATTGTCCAGG	SIRT1	ENSG00000096717	0.825409120921926	[]	[]	8	hSpCas9	negative selection	2885564
67906882	67906905	10	+	27260157	SF268	viability	GAACATAGACACGCTGGAACAGG	SIRT1	ENSG00000096717	0.686545388055891	[]	[]	8	hSpCas9	negative selection	2886517
67884780	67884803	10	-	27260157	SF268	viability	GGACGACGCGGCCTCCCTGTCGG	SIRT1	ENSG00000096717	0.23406931956072	[]	[]	3	hSpCas9	negative selection	2889697
67884837	67884860	10	+	27260157	SF268	viability	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	1.08707855077169	[]	[]	9	hSpCas9	negative selection	2891057
67891528	67891551	10	-	27260157	SF268	viability	GCAAACTTGAAGAATGGTCTTGG	SIRT1	ENSG00000096717	1.02967731154628	[]	[]	9	hSpCas9	negative selection	2910326
67885035	67885058	10	+	27260157	SF268	viability	CGGGCCTGCAGGGCCCATCTCGG	SIRT1	ENSG00000096717	0.512524767751151	[]	[]	7	hSpCas9	negative selection	2910360
67906831	67906854	10	+	27260157	SF268	viability	ATTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	0.523496051805856	[]	[]	8	hSpCas9	negative selection	2911854
67884885	67884908	10	-	27260157	SF268	viability	CGCCGGCACCTCACGCTCTGGGG	SIRT1	ENSG00000096717	-0.78442533383969	[]	[]	-6	hSpCas9	negative selection	2914834
67885199	67885222	10	-	27260157	SF268	viability	CTCAGGCCAGTAGGAGCCCGGGG	SIRT1	ENSG00000096717	-0.555972755803501	[]	[]	-4	hSpCas9	negative selection	2916494
67891534	67891557	10	-	27260157	SF268	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	1.1055524197255	[]	[]	9	hSpCas9	negative selection	2916645
67906781	67906804	10	+	27260157	SF268	viability	TTGATACAGGAAATATATCCTGG	SIRT1	ENSG00000096717	-0.409576886601854	[]	[]	-3	hSpCas9	negative selection	2917423
67906899	67906922	10	+	27260157	SF268	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-1.00998357736235	[]	[]	-7	hSpCas9	negative selection	2922763
67906810	67906833	10	-	27260157	SF268	viability	ATTTGTGACAGAGAGATGGCTGG	SIRT1	ENSG00000096717	1.10074628838575	[]	[]	9	hSpCas9	negative selection	2924829
67906888	67906911	10	+	27260157	SF268	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	-0.145748444901655	[]	[]	-1	hSpCas9	negative selection	2927726
67884807	67884830	10	-	27260157	SF268	viability	CCTCTTGCGGAGCGGCTCCCCGG	SIRT1	ENSG00000096717	-0.545782218373814	[]	[]	-4	hSpCas9	negative selection	2948683
67906836	67906859	10	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	0.28758151182655084	[4,4]	[5,4]	6	hSpCas9	positive selection	3020378
67909390	67909413	10	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-0.351022581255955	[2,3]	[1,2]	-5	hSpCas9	positive selection	3020379
67908088	67908111	10	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.3481300632607154	[3,3]	[3,4]	7	hSpCas9	positive selection	3020380
67909292	67909315	10	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TCTGGTTTCATGATAGCAAGCGG	SIRT1	ENSG00000096717	0.7398125602608435	[3,3]	[5,5]	9	hSpCas9	positive selection	3020381
67906836	67906859	10	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-0.06377420305263332	[4,4]	[3,2]	-1	hSpCas9	positive selection	3088236
67909390	67909413	10	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-0.2047664922273964	[2,2]	[2,0]	-3	hSpCas9	positive selection	3088237
67908088	67908111	10	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.17768721495459594	[3,3]	[3,2]	3	hSpCas9	positive selection	3088238
67909292	67909315	10	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TCTGGTTTCATGATAGCAAGCGG	SIRT1	ENSG00000096717	-0.5390090313929525	[3,3]	[2,0]	-7	hSpCas9	positive selection	3088239
67906899	67906922		+	24336571	A375	resistance to PLX after 7 days	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.10994942721954121	[14,17]	[17,17]	3	hSpCas9	positive selection	3144330
67891534	67891557		-	24336571	A375	resistance to PLX after 7 days	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	-0.15816605896805536	[2,1]	[1,1]	-5	hSpCas9	positive selection	3144331
67891423	67891446		-	24336571	A375	resistance to PLX after 7 days	CCATCCCTTGACCTGAAGTCAGG	SIRT1	ENSG00000096717	-0.04967807378100797	[7,6]	[7,5]	-1	hSpCas9	positive selection	3144332
67906876	67906899		+	24336571	A375	resistance to PLX after 7 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.24906507609637538	[10,11]	[14,12]	7	hSpCas9	positive selection	3144333
67891489	67891512		-	24336571	A375	resistance to PLX after 7 days	TCAATATCAAACATCGCTTGAGG	SIRT1	ENSG00000096717	-0.07098057222108822	[19,17]	[18,16]	-2	hSpCas9	positive selection	3144334
67906899	67906922		+	24336571	A375	resistance to PLX after 14 days	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.48670148285504167	[14,15]	[3,4]	-6	hSpCas9	positive selection	3202123
67891534	67891557		-	24336571	A375	resistance to PLX after 14 days	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.5265682775995666	[1,2]	[1,1]	5	hSpCas9	positive selection	3202124
67891423	67891446		-	24336571	A375	resistance to PLX after 14 days	CCATCCCTTGACCTGAAGTCAGG	SIRT1	ENSG00000096717	-0.19505167212537733	[8,6]	[2,2]	-2	hSpCas9	positive selection	3202125
67906876	67906899		+	24336571	A375	resistance to PLX after 14 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.16836042139909768	[8,8]	[3,4]	1	hSpCas9	positive selection	3202126
67891489	67891512		-	24336571	A375	resistance to PLX after 14 days	TCAATATCAAACATCGCTTGAGG	SIRT1	ENSG00000096717	0.04402189588532762	[18,10]	[5,7]	0	hSpCas9	positive selection	3202127
67906899	67906922		+	24336571	A375	viability after 7 days	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.004912161799612236	[16]	[14,17]	0	hSpCas9	negative selection	3259916
67891534	67891557		-	24336571	A375	viability after 7 days	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.026378995776478398	[1]	[2,1]	0	hSpCas9	negative selection	3259917
67891423	67891446		-	24336571	A375	viability after 7 days	CCATCCCTTGACCTGAAGTCAGG	SIRT1	ENSG00000096717	-0.16506731563307386	[8]	[7,6]	-2	hSpCas9	negative selection	3259918
67906876	67906899		+	24336571	A375	viability after 7 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.3793503667700597	[33]	[10,11]	-9	hSpCas9	negative selection	3259919
67891489	67891512		-	24336571	A375	viability after 7 days	TCAATATCAAACATCGCTTGAGG	SIRT1	ENSG00000096717	0.13838009280177282	[17]	[19,17]	2	hSpCas9	negative selection	3259920
67906899	67906922		+	24336571	A375	viability after 14 days	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.0914416128620984	[16]	[14,15]	-1	hSpCas9	negative selection	3317709
67891534	67891557		-	24336571	A375	viability after 14 days	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.24923549117521393	[1]	[1,2]	3	hSpCas9	negative selection	3317710
67891423	67891446		-	24336571	A375	viability after 14 days	CCATCCCTTGACCTGAAGTCAGG	SIRT1	ENSG00000096717	-0.08264693704745096	[8]	[8,6]	-1	hSpCas9	negative selection	3317711
67906876	67906899		+	24336571	A375	viability after 14 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.7544894188881028	[33]	[8,8]	-9	hSpCas9	negative selection	3317712
67891489	67891512		-	24336571	A375	viability after 14 days	TCAATATCAAACATCGCTTGAGG	SIRT1	ENSG00000096717	-0.16213616756777544	[17]	[18,10]	-2	hSpCas9	negative selection	3317713
67891534	67891557	10	-	27383988	293T	resistance to West Nile virus (flavivirus)	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.3148117061065953	[122,122]	[0,0]	1	hSpCas9	positive selection	3392502
67891533	67891556	10	+	27383988	293T	resistance to West Nile virus (flavivirus)	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	-0.6851882938934047	[245,245]	[0,0]	-5	hSpCas9	positive selection	3392503
67908068	67908091	10	-	27383988	293T	resistance to West Nile virus (flavivirus)	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-1.4807660481746554	[426,426]	[0,0]	-8	hSpCas9	positive selection	3392504
67906835	67906858	10	+	26780180	HT29	viability (Avana library 4 designs)	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-0.18197694636809	[]	[]	-3	hSpCas9	negative selection	3458890
67909390	67909413	10	-	26780180	HT29	viability (Avana library 4 designs)	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	0.258921864440466	[]	[]	0	hSpCas9	negative selection	3458891
67908087	67908110	10	+	26780180	HT29	viability (Avana library 4 designs)	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.861055551404855	[]	[]	3	hSpCas9	negative selection	3458892
67909292	67909315	10	-	26780180	HT29	viability (Avana library 4 designs)	TCTGGTTTCATGATAGCAAGCGG	SIRT1	ENSG00000096717	1.38993591169036	[]	[]	5	hSpCas9	negative selection	3458893
67909292	67909315	10	-	26780180	A375	viability (Avana lentiCRISPRv2)	TCTGGTTTCATGATAGCAAGCGG	SIRT1	ENSG00000096717	0.861670548354598	[]	[]	1	hSpCas9	negative selection	3558549
67908087	67908110	10	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	1.49154538242132	[]	[]	2	hSpCas9	negative selection	3558550
67906835	67906858	10	+	26780180	A375	viability (Avana lentiCRISPRv2)	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-1.30550889169203	[]	[]	-2	hSpCas9	negative selection	3558551
67909390	67909413	10	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-11.0375369571161	[]	[]	-8	hSpCas9	negative selection	3558552
67909262	67909285	10	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	-3.68164101332518	[]	[]	-4	hSpCas9	negative selection	3558553
67906814	67906837	10	-	26780180	A375	viability (Avana lentiCRISPRv2)	ATGAATTTGTGACAGAGAGATGG	SIRT1	ENSG00000096717	-4.25677854848259	[]	[]	-5	hSpCas9	negative selection	3558554
67909292	67909315	10	-	26780180	A375	viability (Avana lentiGuide)	TCTGGTTTCATGATAGCAAGCGG	SIRT1	ENSG00000096717	-1.6825610635724	[]	[]	-3	hSpCas9	negative selection	3667208
67908087	67908110	10	+	26780180	A375	viability (Avana lentiGuide)	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.228079987825192	[]	[]	0	hSpCas9	negative selection	3667209
67906835	67906858	10	+	26780180	A375	viability (Avana lentiGuide)	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-0.254562622889811	[]	[]	0	hSpCas9	negative selection	3667210
67909390	67909413	10	-	26780180	A375	viability (Avana lentiGuide)	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-4.72738969794891	[]	[]	-7	hSpCas9	negative selection	3667211
67909262	67909285	10	-	26780180	A375	viability (Avana lentiGuide)	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	4.9546098822046	[]	[]	4	hSpCas9	negative selection	3667212
67906814	67906837	10	-	26780180	A375	viability (Avana lentiGuide)	ATGAATTTGTGACAGAGAGATGG	SIRT1	ENSG00000096717	0.95147980222793	[]	[]	1	hSpCas9	negative selection	3667213
67909292	67909315	10	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCTGGTTTCATGATAGCAAGCGG	SIRT1	ENSG00000096717	-0.07805444335823962	[5]	[5,4]	-1	hSpCas9	positive selection	3775815
67908087	67908110	10	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.12275334353094042	[4]	[5,4]	3	hSpCas9	positive selection	3775816
67906835	67906858	10	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-0.10858612743996068	[6]	[5,5]	-2	hSpCas9	positive selection	3775817
67909390	67909413	10	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-0.007998767924849659	[4]	[4,3]	0	hSpCas9	positive selection	3775818
67909262	67909285	10	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	0.13461158395812106	[4]	[4,4]	3	hSpCas9	positive selection	3775819
67906814	67906837	10	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATGAATTTGTGACAGAGAGATGG	SIRT1	ENSG00000096717	0.23921762468529068	[6]	[5,8]	6	hSpCas9	positive selection	3775820
67909292	67909315	10	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCTGGTTTCATGATAGCAAGCGG	SIRT1	ENSG00000096717	0.24591275192743806	[5]	[6,4]	6	hSpCas9	positive selection	3884422
67908087	67908110	10	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.23073819713103622	[5]	[6,5]	6	hSpCas9	positive selection	3884423
67906835	67906858	10	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	0.29418897983101744	[6]	[6,6]	7	hSpCas9	positive selection	3884424
67909390	67909413	10	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	0.25798914692911146	[4]	[4,4]	7	hSpCas9	positive selection	3884425
67909262	67909285	10	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	0.37911112459814506	[5]	[6,5]	9	hSpCas9	positive selection	3884426
67906814	67906837	10	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATGAATTTGTGACAGAGAGATGG	SIRT1	ENSG00000096717	0.08106022011686667	[5]	[5,3]	1	hSpCas9	positive selection	3884427
67906899	67906922	10	+	26780180	A375	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	1.35856217617451	[]	[]	7	hSpCas9	negative selection	3994478
67891533	67891556	10	+	26780180	A375	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.748541777383311	[]	[]	2	hSpCas9	negative selection	3994479
67891534	67891557	10	-	26780180	A375	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	1.21317748556352	[]	[]	6	hSpCas9	negative selection	3994480
67908068	67908091	10	-	26780180	A375	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	1.13868218167299	[]	[]	6	hSpCas9	negative selection	3994481
67908087	67908110	10	+	26780180	A375	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	1.5578417687774	[]	[]	8	hSpCas9	negative selection	3994482
67906876	67906899	10	+	26780180	A375	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	2.27240072055856	[]	[]	9	hSpCas9	negative selection	3994483
67906899	67906922	10	+	26780180	HT29	viability (GeCKOv2 library)	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	1.37902409048281	[]	[]	7	hSpCas9	negative selection	4102444
67891533	67891556	10	+	26780180	HT29	viability (GeCKOv2 library)	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.430836229433624	[]	[]	1	hSpCas9	negative selection	4102445
67891534	67891557	10	-	26780180	HT29	viability (GeCKOv2 library)	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.983598730102544	[]	[]	4	hSpCas9	negative selection	4102446
67908068	67908091	10	-	26780180	HT29	viability (GeCKOv2 library)	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	1.70846598294218	[]	[]	8	hSpCas9	negative selection	4102447
67908087	67908110	10	+	26780180	HT29	viability (GeCKOv2 library)	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.0585565342933708	[]	[]	0	hSpCas9	negative selection	4102448
67906876	67906899	10	+	26780180	HT29	viability (GeCKOv2 library)	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	1.84952656812152	[]	[]	8	hSpCas9	negative selection	4102449
67906899	67906922	10	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.25520622473084464	[4]	[2,2]	-6	hSpCas9	positive selection	4170281
67891534	67891557	10	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	-0.509159403441763	[1]	[0,0]	-8	hSpCas9	positive selection	4170282
67891423	67891446	10	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CCATCCCTTGACCTGAAGTCAGG	SIRT1	ENSG00000096717	0.38922850275543297	[2]	[3,1]	8	hSpCas9	positive selection	4170283
67906876	67906899	10	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.022887440533960787	[3]	[2,1]	0	hSpCas9	positive selection	4170284
67891489	67891512	10	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TCAATATCAAACATCGCTTGAGG	SIRT1	ENSG00000096717	0.6935778760436027	[4]	[6,2]	9	hSpCas9	positive selection	4170285
67906899	67906922	10	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.6409188925194136	[4]	[3,1,0,3]	4	hSpCas9	positive selection	4234303
67891534	67891557	10	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.3984893905031883	[0]	[0,0,0,0]	3	hSpCas9	positive selection	4234304
67891423	67891446	10	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CCATCCCTTGACCTGAAGTCAGG	SIRT1	ENSG00000096717	-0.41964295438066757	[4]	[0,4,0,0]	-6	hSpCas9	positive selection	4234305
67906876	67906899	10	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.04353804267737266	[4]	[2,3,2,0]	0	hSpCas9	positive selection	4234306
67891489	67891512	10	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TCAATATCAAACATCGCTTGAGG	SIRT1	ENSG00000096717	-0.24524588093027763	[4]	[4,0,1,0]	-4	hSpCas9	positive selection	4234307
67908087	67908110	10	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.047697260589369406	[3]	[3,2]	-1	hSpCas9	positive selection	4297846
67906899	67906922	10	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.47824536883124097	[2]	[2,2]	8	hSpCas9	positive selection	4297847
67906876	67906899	10	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.46803092487013354	[4]	[2,1]	-7	hSpCas9	positive selection	4297848
67891534	67891557	10	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.3811449422022548	[2]	[2,2]	7	hSpCas9	positive selection	4362100
67891533	67891556	10	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.603768302558882	[3]	[4,4]	9	hSpCas9	positive selection	4362101
67908068	67908091	10	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.3996994520705375	[4]	[3,1]	-7	hSpCas9	positive selection	4362102
67906832	67906854	10	+	27760321	OCIAML3	viability	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	-0.7602613352432261	[128,119]	[73,35]	-6	hSpCas9	negative selection	4439082
67906900	67906922	10	+	27760321	OCIAML3	viability	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.2517318269589147	[372,272]	[257,349]	3	hSpCas9	negative selection	4439083
67908049	67908071	10	-	27760321	OCIAML3	viability	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	0.14994072998095492	[391,293]	[262,336]	1	hSpCas9	negative selection	4439084
67909387	67909409	10	-	27760321	OCIAML3	viability	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	-0.40047241534048283	[225,152]	[86,141]	-4	hSpCas9	negative selection	4439085
67909424	67909446	10	-	27760321	OCIAML3	viability	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	-0.4946592173759581	[170,125]	[39,135]	-5	hSpCas9	negative selection	4439086
67906832	67906854	10	+	27760321	OCIAML2	viability	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	0.24262579583825739	[128,119]	[110,129]	3	hSpCas9	negative selection	4522545
67906900	67906922	10	+	27760321	OCIAML2	viability	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.33446633314960456	[372,272]	[293,368]	4	hSpCas9	negative selection	4522546
67908049	67908071	10	-	27760321	OCIAML2	viability	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	-0.06074099323970167	[391,293]	[252,277]	-1	hSpCas9	negative selection	4522547
67909387	67909409	10	-	27760321	OCIAML2	viability	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	0.44535931785660177	[225,152]	[187,229]	6	hSpCas9	negative selection	4522548
67909424	67909446	10	-	27760321	OCIAML2	viability	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	0.2931496080526439	[170,125]	[125,171]	4	hSpCas9	negative selection	4522549
67906832	67906854	10	+	27760321	MV411	viability	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	-2.472511948350503	[128,119]	[23,0]	-9	hSpCas9	negative selection	4606008
67906900	67906922	10	+	27760321	MV411	viability	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.6546718345319401	[372,272]	[317,353]	5	hSpCas9	negative selection	4606009
67908049	67908071	10	-	27760321	MV411	viability	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	-0.5515003529354535	[391,293]	[73,271]	-4	hSpCas9	negative selection	4606010
67909387	67909409	10	-	27760321	MV411	viability	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	0.5183485015768559	[225,152]	[259,51]	4	hSpCas9	negative selection	4606011
67909424	67909446	10	-	27760321	MV411	viability	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	0.8648384247784765	[170,125]	[211,123]	6	hSpCas9	negative selection	4606012
67906832	67906854	10	+	27760321	HL60	viability	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	0.4539335402698903	[128,119]	[150,126]	5	hSpCas9	negative selection	4689471
67906900	67906922	10	+	27760321	HL60	viability	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	1.1834099704361556	[372,272]	[546,642]	9	hSpCas9	negative selection	4689472
67908049	67908071	10	-	27760321	HL60	viability	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	0.4881755496153442	[391,293]	[362,417]	6	hSpCas9	negative selection	4689473
67909387	67909409	10	-	27760321	HL60	viability	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	-0.18493324082131113	[225,152]	[149,117]	-2	hSpCas9	negative selection	4689474
67909424	67909446	10	-	27760321	HL60	viability	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	0.21684447284306896	[170,125]	[145,132]	2	hSpCas9	negative selection	4689475
67906832	67906854	10	+	27760321	HT1080	viability	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	0.29974109185907394	[119,93]	[30,75]	1	hSpCas9	negative selection	4772934
67906900	67906922	10	+	27760321	HT1080	viability	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-2.6406647662276197	[272,212]	[15,14]	-7	hSpCas9	negative selection	4772935
67908049	67908071	10	-	27760321	HT1080	viability	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	1.294084508725027	[293,229]	[360,140]	7	hSpCas9	negative selection	4772936
67909387	67909409	10	-	27760321	HT1080	viability	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	-1.3573494861575568	[152,119]	[4,38]	-5	hSpCas9	negative selection	4772937
67909424	67909446	10	-	27760321	HT1080	viability	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	-3.280782525050295	[125,98]	[6,1]	-7	hSpCas9	negative selection	4772938
67906832	67906854	10	+	27760321	HT29	viability after 7 days	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	-0.011455677262336872	[119,93]	[263,73,90]	0	hSpCas9	negative selection	4856397
67906900	67906922	10	+	27760321	HT29	viability after 7 days	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	1.0269684369985779	[272,212]	[704,553,658]	9	hSpCas9	negative selection	4856398
67908049	67908071	10	-	27760321	HT29	viability after 7 days	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	0.20588364840463158	[293,229]	[417,286,461]	3	hSpCas9	negative selection	4856399
67909387	67909409	10	-	27760321	HT29	viability after 7 days	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	-0.5823391398486388	[152,119]	[151,133,71]	-7	hSpCas9	negative selection	4856400
67909424	67909446	10	-	27760321	HT29	viability after 7 days	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	0.23879226715932278	[125,98]	[34,170,282]	3	hSpCas9	negative selection	4856401
67906832	67906854	10	+	27760321	HT29	viability after 25 days	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	-0.24531572693954273	[119,93]	[96,124,85]	-3	hSpCas9	negative selection	4939860
67906900	67906922	10	+	27760321	HT29	viability after 25 days	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	1.0550234840880608	[272,212]	[588,574,563]	9	hSpCas9	negative selection	4939861
67908049	67908071	10	-	27760321	HT29	viability after 25 days	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	0.7381826401269166	[293,229]	[487,420,599]	8	hSpCas9	negative selection	4939862
67909387	67909409	10	-	27760321	HT29	viability after 25 days	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	0.3345857773168892	[152,119]	[222,188,173]	3	hSpCas9	negative selection	4939863
67909424	67909446	10	-	27760321	HT29	viability after 25 days	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	0.6675785708123976	[125,98]	[217,212,177]	7	hSpCas9	negative selection	4939864
67906832	67906854	10	+	27760321	HT29	viability after 22 days	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	-0.0847737404801403	[119,93]	[47,170,132]	-1	hSpCas9	negative selection	5023323
67906900	67906922	10	+	27760321	HT29	viability after 22 days	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	1.2418825510383045	[272,212]	[623,727,641]	9	hSpCas9	negative selection	5023324
67908049	67908071	10	-	27760321	HT29	viability after 22 days	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	0.7942153129186837	[293,229]	[671,580,316]	8	hSpCas9	negative selection	5023325
67909387	67909409	10	-	27760321	HT29	viability after 22 days	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	0.7200850771851909	[152,119]	[80,327,376]	7	hSpCas9	negative selection	5023326
67909424	67909446	10	-	27760321	HT29	viability after 22 days	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	0.42490033877925626	[125,98]	[231,162,126]	4	hSpCas9	negative selection	5023327
67906832	67906854	10	+	27760321	HT29	viability after 19 days	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	-0.621946018388118	[119,93]	[166,8,71]	-5	hSpCas9	negative selection	5106786
67906900	67906922	10	+	27760321	HT29	viability after 19 days	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.41393176031250256	[272,212]	[250,555,293]	4	hSpCas9	negative selection	5106787
67908049	67908071	10	-	27760321	HT29	viability after 19 days	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	0.09649361806275597	[293,229]	[419,325,228]	0	hSpCas9	negative selection	5106788
67909387	67909409	10	-	27760321	HT29	viability after 19 days	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	0.45302876982977935	[152,119]	[57,222,338]	4	hSpCas9	negative selection	5106789
67909424	67909446	10	-	27760321	HT29	viability after 19 days	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	-0.2072893310719539	[125,98]	[69,173,86]	-2	hSpCas9	negative selection	5106790
67906832	67906854	10	+	27760321	HT29	viability after 16 days	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	-0.863390216101652	[119,93]	[108,8,84]	-6	hSpCas9	negative selection	5190249
67906900	67906922	10	+	27760321	HT29	viability after 16 days	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.9573956779738071	[272,212]	[447,377,753]	9	hSpCas9	negative selection	5190250
67908049	67908071	10	-	27760321	HT29	viability after 16 days	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	0.1862688512267005	[293,229]	[488,346,178]	2	hSpCas9	negative selection	5190251
67909387	67909409	10	-	27760321	HT29	viability after 16 days	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	-0.4940603792192926	[152,119]	[84,152,83]	-5	hSpCas9	negative selection	5190252
67909424	67909446	10	-	27760321	HT29	viability after 16 days	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	0.6088103432857948	[125,98]	[70,291,198]	7	hSpCas9	negative selection	5190253
67906832	67906854	10	+	27760321	HT29	viability after 13 days	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	0.04474406462353486	[119,93]	[181,89,112]	0	hSpCas9	negative selection	5273712
67906900	67906922	10	+	27760321	HT29	viability after 13 days	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.8953256511506275	[272,212]	[553,530,489]	9	hSpCas9	negative selection	5273713
67908049	67908071	10	-	27760321	HT29	viability after 13 days	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	-0.08795200510820472	[293,229]	[257,244,350]	-1	hSpCas9	negative selection	5273714
67909387	67909409	10	-	27760321	HT29	viability after 13 days	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	0.7764557831718162	[152,119]	[221,421,175]	8	hSpCas9	negative selection	5273715
67909424	67909446	10	-	27760321	HT29	viability after 13 days	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	0.13913221588423008	[125,98]	[95,115,214]	1	hSpCas9	negative selection	5273716
67906832	67906854	10	+	27760321	HT29	viability after 10 days	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	-0.3013834131404889	[119,93]	[82,53,184]	-4	hSpCas9	negative selection	5357175
67906900	67906922	10	+	27760321	HT29	viability after 10 days	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.8099084470117561	[272,212]	[399,619,576]	9	hSpCas9	negative selection	5357176
67908049	67908071	10	-	27760321	HT29	viability after 10 days	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	0.27386663484972273	[293,229]	[299,485,402]	3	hSpCas9	negative selection	5357177
67909387	67909409	10	-	27760321	HT29	viability after 10 days	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	0.5367334908018382	[152,119]	[189,254,295]	7	hSpCas9	negative selection	5357178
67909424	67909446	10	-	27760321	HT29	viability after 10 days	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	-0.23556333158199005	[125,98]	[57,105,191]	-3	hSpCas9	negative selection	5357179
67906832	67906854	10	+	27760321	MOLM13	viability	TTCATAGCCTTGTCAGATAAGG	SIRT1	ENSG00000096717	0.4132546442006453	[128,119]	[58,122]	3	hSpCas9	negative selection	5440638
67906900	67906922	10	+	27760321	MOLM13	viability	ACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.26257497790555717	[372,272]	[40,365]	1	hSpCas9	negative selection	5440639
67908049	67908071	10	-	27760321	MOLM13	viability	AGGCAAGATGCTGTTGCAAAGG	SIRT1	ENSG00000096717	-0.4823906875519608	[391,293]	[172,106]	-3	hSpCas9	negative selection	5440640
67909387	67909409	10	-	27760321	MOLM13	viability	AGACCCAATAACAATGAGGAGG	SIRT1	ENSG00000096717	0.5839937718723217	[225,152]	[100,206]	4	hSpCas9	negative selection	5440641
67909424	67909446	10	-	27760321	MOLM13	viability	TACTTGGAATTAGTGCTACTGG	SIRT1	ENSG00000096717	-0.19488892291522242	[170,125]	[51,89]	-1	hSpCas9	negative selection	5440642
67884751	67884774	10	+	27661255	K562	viability	GCCCGGCGGCTCCCCCTCGGCGG	SIRT1	ENSG00000096717	0.04909557393562625	[416,310]	[323,283]	1	dCas9-KRAB	negative selection	5511136
67885130	67885153	10	+	27661255	K562	viability	GCGGCGGCGATTGGGTACCGAGG	SIRT1	ENSG00000096717	0.009252775494533405	[673,667]	[572,510]	0	dCas9-KRAB	negative selection	5511137
67885144	67885167	10	+	27661255	K562	viability	GTACCGAGGTGCGCAGGGTGCGG	SIRT1	ENSG00000096717	0.05110609394249954	[698,794]	[612,619]	1	dCas9-KRAB	negative selection	5511138
67884744	67884767	10	-	27661255	K562	viability	GGGGGAGCCGCCGGGCTGAAGGG	SIRT1	ENSG00000096717	-0.3730679434059454	[1951,2157]	[1336,1203]	-7	dCas9-KRAB	negative selection	5511139
67908087	67908110	10	+	27260156	BXPC3	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.9002918474482596	[909]	[1384,2064,1747,1937]	9	hSpCas9	negative selection	5570306
67906899	67906922	10	+	27260156	BXPC3	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.5469227983618976	[224]	[350,400,227,391]	9	hSpCas9	negative selection	5570307
67906876	67906899	10	+	27260156	BXPC3	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.5338471375101448	[1049]	[1543,1445,1548,1852]	9	hSpCas9	negative selection	5570308
67891534	67891557	10	-	27260156	BXPC3	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.6856621541885835	[326]	[482,519,478,745]	9	hSpCas9	negative selection	5634560
67891533	67891556	10	+	27260156	BXPC3	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.8222558807726035	[629]	[1248,969,1153,1295]	9	hSpCas9	negative selection	5634561
67908068	67908091	10	-	27260156	BXPC3	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.023108825604760463	[1084]	[1049,968,1166,1479]	0	hSpCas9	negative selection	5634562
67908087	67908110	10	+	27260156	A673	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.09406712628894265	[909]	[1168,986,818,1143]	-2	hSpCas9	negative selection	5691557
67906899	67906922	10	+	27260156	A673	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.13578888371146824	[224]	[302,215,205,266]	-3	hSpCas9	negative selection	5691558
67906876	67906899	10	+	27260156	A673	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.38655761457833904	[1049]	[993,869,930,1072]	-7	hSpCas9	negative selection	5691559
67891534	67891557	10	-	27260156	A673	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.29385880774604123	[326]	[505,529,505,377]	7	hSpCas9	negative selection	5755811
67891533	67891556	10	+	27260156	A673	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.11751263967315717	[629]	[1020,688,717,883]	3	hSpCas9	negative selection	5755812
67908068	67908091	10	-	27260156	A673	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.18729730029281577	[1084]	[1305,1237,857,1193]	-5	hSpCas9	negative selection	5755813
67908087	67908110	10	+	27260156	A375	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.19521316389420973	[909]	[1133,1232,1507,1013]	3	hSpCas9	negative selection	5812808
67906899	67906922	10	+	27260156	A375	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.0714948974601487	[224]	[175,339,414,190]	1	hSpCas9	negative selection	5812809
67906876	67906899	10	+	27260156	A375	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.11382139308005779	[1049]	[945,1465,1112,1057]	-2	hSpCas9	negative selection	5812810
67891534	67891557	10	-	27260156	A375	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.31572157294164177	[326]	[601,441,589,284]	4	hSpCas9	negative selection	5877062
67891533	67891556	10	+	27260156	A375	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.21426565404667552	[629]	[937,1031,846,644]	3	hSpCas9	negative selection	5877063
67908068	67908091	10	-	27260156	A375	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.2895701779973723	[1084]	[1407,1937,1441,1464]	4	hSpCas9	negative selection	5877064
67908087	67908110	10	+	27260156	COLO741	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.23569797060594444	[909]	[1566,1288,1271]	5	hSpCas9	negative selection	5934059
67906899	67906922	10	+	27260156	COLO741	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.2701822523929507	[224]	[277,188,249]	-5	hSpCas9	negative selection	5934060
67906876	67906899	10	+	27260156	COLO741	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.1372786018984249	[1049]	[1552,1046,1093]	-3	hSpCas9	negative selection	5934061
67891534	67891557	10	-	27260156	COLO741	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.3761591076548497	[326]	[448,502,656]	7	hSpCas9	negative selection	5998313
67891533	67891556	10	+	27260156	COLO741	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.19524926010821453	[629]	[956,974,839]	4	hSpCas9	negative selection	5998314
67908068	67908091	10	-	27260156	COLO741	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.03474917285806667	[1084]	[1649,1238,1203]	0	hSpCas9	negative selection	5998315
67908087	67908110	10	+	27260156	CAL120	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.38384630904614847	[909]	[1571,1268,1602]	6	hSpCas9	negative selection	6055310
67906899	67906922	10	+	27260156	CAL120	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.6806476885428097	[224]	[194,155,175]	-7	hSpCas9	negative selection	6055311
67906876	67906899	10	+	27260156	CAL120	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.450609632049663	[1049]	[1303,815,802]	-6	hSpCas9	negative selection	6055312
67891534	67891557	10	-	27260156	CAL120	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.0038306915076652404	[326]	[588,306,355]	0	hSpCas9	negative selection	6119564
67891533	67891556	10	+	27260156	CAL120	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.16713320175673219	[629]	[1158,791,733]	2	hSpCas9	negative selection	6119565
67908068	67908091	10	-	27260156	CAL120	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.19160700181713897	[1084]	[1719,1560,1373]	3	hSpCas9	negative selection	6119566
67908087	67908110	10	+	27260156	CADOES1	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.036592928306691364	[909]	[745,804,892,857]	0	hSpCas9	negative selection	6176561
67906899	67906922	10	+	27260156	CADOES1	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.6788962997151355	[224]	[186,104,116,112]	-8	hSpCas9	negative selection	6176562
67906876	67906899	10	+	27260156	CADOES1	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.5537841164812264	[1049]	[556,872,560,670]	-7	hSpCas9	negative selection	6176563
67891534	67891557	10	-	27260156	CADOES1	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.20476720353152517	[326]	[335,385,307,372]	3	hSpCas9	negative selection	6240815
67891533	67891556	10	+	27260156	CADOES1	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.09394834978497268	[629]	[455,721,572,755]	1	hSpCas9	negative selection	6240816
67908068	67908091	10	-	27260156	CADOES1	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.09027969184813678	[1084]	[1046,1189,920,1141]	1	hSpCas9	negative selection	6240817
67908087	67908110	10	+	27260156	EWS502	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.08929455084006177	[909]	[939,883,886,905]	-2	hSpCas9	negative selection	6297812
67906899	67906922	10	+	27260156	EWS502	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.7033365759245194	[224]	[159,196,111,108]	-8	hSpCas9	negative selection	6297813
67906876	67906899	10	+	27260156	EWS502	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.6158072469945228	[1049]	[640,680,660,943]	-7	hSpCas9	negative selection	6297814
67891534	67891557	10	-	27260156	EWS502	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.27819829892945525	[326]	[296,431,474,494]	5	hSpCas9	negative selection	6362066
67891533	67891556	10	+	27260156	EWS502	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	-0.29520733234042973	[629]	[335,740,515,600]	-5	hSpCas9	negative selection	6362067
67908068	67908091	10	-	27260156	EWS502	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.03800903968484426	[1084]	[993,1092,1545,1107]	0	hSpCas9	negative selection	6362068
67908087	67908110	10	+	27260156	EW8	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.12520777574734654	[909]	[982,647,436,708]	-2	hSpCas9	negative selection	6419063
67906899	67906922	10	+	27260156	EW8	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.06023943967766199	[224]	[200,157,215,119]	-1	hSpCas9	negative selection	6419064
67906876	67906899	10	+	27260156	EW8	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.3680429646093808	[1049]	[644,765,638,587]	-6	hSpCas9	negative selection	6419065
67891534	67891557	10	-	27260156	EW8	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.3134561052288021	[326]	[411,303,289,325]	6	hSpCas9	negative selection	6483317
67891533	67891556	10	+	27260156	EW8	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.033490876901140554	[629]	[549,538,437,578]	0	hSpCas9	negative selection	6483318
67908068	67908091	10	-	27260156	EW8	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.2329249964261888	[1084]	[849,835,632,702]	-4	hSpCas9	negative selection	6483319
67908087	67908110	10	+	27260156	CORL105	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.07983394491209783	[909]	[1010,764,1392,927]	-1	hSpCas9	negative selection	6540314
67906899	67906922	10	+	27260156	CORL105	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.636098345172452	[224]	[135,166,177,196]	-8	hSpCas9	negative selection	6540315
67906876	67906899	10	+	27260156	CORL105	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.3487088287629202	[1049]	[1197,971,879,805]	-6	hSpCas9	negative selection	6540316
67891534	67891557	10	-	27260156	CORL105	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	-0.054996843443642196	[326]	[260,460,447,310]	-1	hSpCas9	negative selection	6604568
67891533	67891556	10	+	27260156	CORL105	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	-0.5961341451949153	[629]	[489,519,437,494]	-8	hSpCas9	negative selection	6604569
67908068	67908091	10	-	27260156	CORL105	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.1295613985306452	[1084]	[1266,1109,1280,1009]	-2	hSpCas9	negative selection	6604570
67908087	67908110	10	+	27260156	HS294T	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.23105314832045754	[909]	[262,478,386,557]	3	hSpCas9	negative selection	6661565
67906899	67906922	10	+	27260156	HS294T	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	1.3658308699606272	[224]	[490,79,74,229]	9	hSpCas9	negative selection	6661566
67906876	67906899	10	+	27260156	HS294T	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.2605779910787924	[1049]	[382,489,557,529]	3	hSpCas9	negative selection	6661567
67891534	67891557	10	-	27260156	HS294T	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.6264259572785366	[326]	[143,171,128,369]	7	hSpCas9	negative selection	6725819
67891533	67891556	10	+	27260156	HS294T	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.8971374922371518	[629]	[428,430,243,763]	9	hSpCas9	negative selection	6725820
67908068	67908091	10	-	27260156	HS294T	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.08966391174709121	[1084]	[490,293,343,697]	1	hSpCas9	negative selection	6725821
67908087	67908110	10	+	27260156	HCC44	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.25296783998019634	[909]	[1224,1230,1309,1145]	4	hSpCas9	negative selection	6782816
67906899	67906922	10	+	27260156	HCC44	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.7656215674998008	[224]	[160,173,127,128]	-8	hSpCas9	negative selection	6782817
67906876	67906899	10	+	27260156	HCC44	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.05343607270240991	[1049]	[1094,991,1066,1408]	-1	hSpCas9	negative selection	6782818
67891534	67891557	10	-	27260156	HCC44	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.14797350588372726	[326]	[347,395,530,378]	2	hSpCas9	negative selection	6847070
67891533	67891556	10	+	27260156	HCC44	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.19010707387300063	[629]	[1105,655,581,906]	3	hSpCas9	negative selection	6847071
67908068	67908091	10	-	27260156	HCC44	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.0151041723460823	[1084]	[1240,1084,1762,981]	0	hSpCas9	negative selection	6847072
67908087	67908110	10	+	27260156	G402	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.5297520395688663	[909]	[1054,889,749,442]	-6	hSpCas9	negative selection	6904067
67906899	67906922	10	+	27260156	G402	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.43804777765624925	[224]	[361,185,62,219]	-5	hSpCas9	negative selection	6904068
67906876	67906899	10	+	27260156	G402	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.6918488433498087	[1049]	[716,724,1034,682]	-7	hSpCas9	negative selection	6904069
67891534	67891557	10	-	27260156	G402	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	-0.08575452771267866	[326]	[334,441,402,322]	-1	hSpCas9	negative selection	6968321
67891533	67891556	10	+	27260156	G402	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	-0.28524118840923496	[629]	[490,666,782,564]	-4	hSpCas9	negative selection	6968322
67908068	67908091	10	-	27260156	G402	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.42876816300937537	[1084]	[1741,2189,1776,1446]	5	hSpCas9	negative selection	6968323
67908087	67908110	10	+	27260156	L33	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.20467715749179238	[909]	[1008,479,622,1023]	4	hSpCas9	negative selection	7025318
67906899	67906922	10	+	27260156	L33	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.15943654174292843	[224]	[229,92,199,230]	3	hSpCas9	negative selection	7025319
67906876	67906899	10	+	27260156	L33	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.0015927683150838146	[1049]	[1020,444,698,986]	0	hSpCas9	negative selection	7025320
67891534	67891557	10	-	27260156	L33	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	-0.21988782565981269	[326]	[396,73,222,188]	-5	hSpCas9	negative selection	7089572
67891533	67891556	10	+	27260156	L33	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.10547828696091688	[629]	[570,289,373,837]	2	hSpCas9	negative selection	7089573
67908068	67908091	10	-	27260156	L33	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.24119772316369015	[1084]	[1039,329,582,895]	-5	hSpCas9	negative selection	7089574
67908087	67908110	10	+	27260156	K562	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.18925884876372479	[909]	[623,925,730,569]	-2	hSpCas9	negative selection	7146569
67906899	67906922	10	+	27260156	K562	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.7373093799378434	[224]	[100,88,104,173]	-7	hSpCas9	negative selection	7146570
67906876	67906899	10	+	27260156	K562	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.2685931394331341	[1049]	[610,1310,667,542]	-3	hSpCas9	negative selection	7146571
67891534	67891557	10	-	27260156	K562	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	-0.027715083895192727	[326]	[235,392,157,344]	0	hSpCas9	negative selection	7210823
67891533	67891556	10	+	27260156	K562	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.01591173286064368	[629]	[442,507,788,511]	0	hSpCas9	negative selection	7210824
67908068	67908091	10	-	27260156	K562	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.04283385774982107	[1084]	[828,877,1032,977]	0	hSpCas9	negative selection	7210825
67908087	67908110	10	+	27260156	HT29	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.10774325231949111	[909]	[1290,1408,1041,1059]	2	hSpCas9	negative selection	7267820
67906899	67906922	10	+	27260156	HT29	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.24857025314632897	[224]	[412,160,200,160]	-5	hSpCas9	negative selection	7267821
67906876	67906899	10	+	27260156	HT29	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.1968582942286069	[1049]	[1457,1269,885,898]	-4	hSpCas9	negative selection	7267822
67891534	67891557	10	-	27260156	HT29	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.30148547430195977	[326]	[649,462,461,401]	6	hSpCas9	negative selection	7332074
67891533	67891556	10	+	27260156	HT29	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.25741592309849215	[629]	[1056,942,875,805]	5	hSpCas9	negative selection	7332075
67908068	67908091	10	-	27260156	HT29	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.005391807615252819	[1084]	[1488,1353,1470,989]	0	hSpCas9	negative selection	7332076
67908087	67908110	10	+	27260156	MHHES1	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.1493389040302615	[909]	[1124,1009,914,708]	-3	hSpCas9	negative selection	7389071
67906899	67906922	10	+	27260156	MHHES1	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.24255130761473498	[224]	[364,249,232,61]	-4	hSpCas9	negative selection	7389072
67906876	67906899	10	+	27260156	MHHES1	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.5001446957383888	[1049]	[978,918,760,718]	-7	hSpCas9	negative selection	7389073
67891534	67891557	10	-	27260156	MHHES1	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.1388669600828556	[326]	[339,515,381,382]	2	hSpCas9	negative selection	7453325
67891533	67891556	10	+	27260156	MHHES1	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	-0.3137365317736807	[629]	[616,550,587,527]	-5	hSpCas9	negative selection	7453326
67908068	67908091	10	-	27260156	MHHES1	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.04301643197866456	[1084]	[1715,1333,1363,771]	0	hSpCas9	negative selection	7453327
67908087	67908110	10	+	27260156	MEWO	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.06821876122216863	[909]	[1087,772,854]	1	hSpCas9	negative selection	7510322
67906899	67906922	10	+	27260156	MEWO	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.4267677528171614	[224]	[177,136,158]	-7	hSpCas9	negative selection	7510323
67906876	67906899	10	+	27260156	MEWO	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.2394027971033159	[1049]	[889,920,695]	-5	hSpCas9	negative selection	7510324
67891534	67891557	10	-	27260156	MEWO	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.3467569682760108	[326]	[457,269,452]	7	hSpCas9	negative selection	7574576
67891533	67891556	10	+	27260156	MEWO	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	-0.018418051635678556	[629]	[625,620,506]	0	hSpCas9	negative selection	7574577
67908068	67908091	10	-	27260156	MEWO	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.11345049875987812	[1084]	[1186,922,752]	-2	hSpCas9	negative selection	7574578
67908087	67908110	10	+	27260156	LNCAPCLONEFGC	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.2628137987146396	[909]	[1013,894,1310,788]	4	hSpCas9	negative selection	7631573
67906899	67906922	10	+	27260156	LNCAPCLONEFGC	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.048500109317606954	[224]	[197,151,283,223]	0	hSpCas9	negative selection	7631574
67906876	67906899	10	+	27260156	LNCAPCLONEFGC	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.08234968393568387	[1049]	[1126,832,1137,957]	1	hSpCas9	negative selection	7631575
67891534	67891557	10	-	27260156	LNCAPCLONEFGC	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.5190981362641265	[326]	[384,279,538,520]	7	hSpCas9	negative selection	7695827
67891533	67891556	10	+	27260156	LNCAPCLONEFGC	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.2476882503258624	[629]	[731,552,710,725]	4	hSpCas9	negative selection	7695828
67908068	67908091	10	-	27260156	LNCAPCLONEFGC	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.16226083509363698	[1084]	[1254,859,1082,1210]	2	hSpCas9	negative selection	7695829
67908087	67908110	10	+	27260156	PANC0327	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.17287341787607202	[909]	[874,881,308,792]	-3	hSpCas9	negative selection	7752824
67906899	67906922	10	+	27260156	PANC0327	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.07099578430650944	[224]	[170,215,132,235]	-1	hSpCas9	negative selection	7752825
67906876	67906899	10	+	27260156	PANC0327	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.31845052092521886	[1049]	[750,762,741,733]	-5	hSpCas9	negative selection	7752826
67891534	67891557	10	-	27260156	PANC0327	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.6416236542274465	[326]	[453,485,287,579]	8	hSpCas9	negative selection	7817078
67891533	67891556	10	+	27260156	PANC0327	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	-0.27826957492129123	[629]	[789,342,437,316]	-4	hSpCas9	negative selection	7817079
67908068	67908091	10	-	27260156	PANC0327	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.1148157743467415	[1084]	[1048,739,1121,681]	-2	hSpCas9	negative selection	7817080
67908087	67908110	10	+	27260156	NCIH2009	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.45149139798409554	[909]	[1409,799,674]	-5	hSpCas9	negative selection	7874075
67906899	67906922	10	+	27260156	NCIH2009	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.2784948259571456	[224]	[653,223,321]	4	hSpCas9	negative selection	7874076
67906876	67906899	10	+	27260156	NCIH2009	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.02979215031737792	[1049]	[1455,1348,1508]	0	hSpCas9	negative selection	7874077
67891534	67891557	10	-	27260156	NCIH2009	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	-0.09939518657692248	[326]	[305,416,531]	-1	hSpCas9	negative selection	7938329
67891533	67891556	10	+	27260156	NCIH2009	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	-0.41102042937650834	[629]	[552,789,617]	-5	hSpCas9	negative selection	7938330
67908068	67908091	10	-	27260156	NCIH2009	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.074512233896324	[1084]	[1743,1501,1570]	1	hSpCas9	negative selection	7938331
67908087	67908110	10	+	27260156	NCIH1373	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.004011930665761998	[909]	[929,1073,1141,232]	0	hSpCas9	negative selection	7995326
67906899	67906922	10	+	27260156	NCIH1373	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.7448494059893269	[224]	[143,120,41,80]	-6	hSpCas9	negative selection	7995327
67906876	67906899	10	+	27260156	NCIH1373	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.0030663276666320627	[1049]	[1365,1207,852,342]	0	hSpCas9	negative selection	7995328
67891534	67891557	10	-	27260156	NCIH1373	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.4358682896939253	[326]	[356,427,370,218]	4	hSpCas9	negative selection	8059580
67891533	67891556	10	+	27260156	NCIH1373	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	-0.24531507392199345	[629]	[620,633,573,143]	-2	hSpCas9	negative selection	8059581
67908068	67908091	10	-	27260156	NCIH1373	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.7777015493174961	[1084]	[2776,1870,2027,463]	7	hSpCas9	negative selection	8059582
67908087	67908110	10	+	27260156	PATU8902	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.01573232600071861	[909]	[1410,1246,1348,1061]	0	hSpCas9	negative selection	8116577
67906899	67906922	10	+	27260156	PATU8902	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.33414667767783013	[224]	[139,115,266,494]	-3	hSpCas9	negative selection	8116578
67906876	67906899	10	+	27260156	PATU8902	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.1657374412749878	[1049]	[1262,1746,1094,1134]	-2	hSpCas9	negative selection	8116579
67891534	67891557	10	-	27260156	PATU8902	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.2630757035015809	[326]	[765,529,337,605]	2	hSpCas9	negative selection	8180831
67891533	67891556	10	+	27260156	PATU8902	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	-0.6245065371188769	[629]	[583,426,628,621]	-6	hSpCas9	negative selection	8180832
67908068	67908091	10	-	27260156	PATU8902	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.5179566461577094	[1084]	[1957,1803,2232,2688]	5	hSpCas9	negative selection	8180833
67908087	67908110	10	+	27260156	PANC1	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.11233126771411428	[909]	[863,943,655,495]	-2	hSpCas9	negative selection	8237828
67906899	67906922	10	+	27260156	PANC1	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.5861332749149759	[224]	[134,172,121,96]	-7	hSpCas9	negative selection	8237829
67906876	67906899	10	+	27260156	PANC1	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.23903833965853283	[1049]	[714,1149,645,633]	-4	hSpCas9	negative selection	8237830
67891534	67891557	10	-	27260156	PANC1	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.2907096561467457	[326]	[436,397,320,238]	5	hSpCas9	negative selection	8302082
67891533	67891556	10	+	27260156	PANC1	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.31387230305164016	[629]	[496,662,687,809]	5	hSpCas9	negative selection	8302083
67908068	67908091	10	-	27260156	PANC1	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.052229627988564564	[1084]	[765,1291,838,1013]	0	hSpCas9	negative selection	8302084
67908087	67908110	10	+	27260156	PANC0813	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.8799201648645275	[909]	[1719,2024,2386,1725]	9	hSpCas9	negative selection	8359079
67906899	67906922	10	+	27260156	PANC0813	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.7880915673439627	[224]	[394,476,623,330]	9	hSpCas9	negative selection	8359080
67906876	67906899	10	+	27260156	PANC0813	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.49639856407202854	[1049]	[1833,1503,1934,1695]	7	hSpCas9	negative selection	8359081
67891534	67891557	10	-	27260156	PANC0813	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.4225988191623505	[326]	[554,534,595,383]	6	hSpCas9	negative selection	8423333
67891533	67891556	10	+	27260156	PANC0813	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.8546103632891293	[629]	[1225,1469,1102,1528]	9	hSpCas9	negative selection	8423334
67908068	67908091	10	-	27260156	PANC0813	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.02663317227178763	[1084]	[1265,1188,1597,1144]	0	hSpCas9	negative selection	8423335
67908087	67908110	10	+	27260156	RDES	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.22947023786337772	[909]	[786,801,928,1086]	-4	hSpCas9	negative selection	8480330
67906899	67906922	10	+	27260156	RDES	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.5272097228768566	[224]	[140,178,155,255]	-7	hSpCas9	negative selection	8480331
67906876	67906899	10	+	27260156	RDES	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.4950946224193872	[1049]	[693,748,897,1152]	-7	hSpCas9	negative selection	8480332
67891534	67891557	10	-	27260156	RDES	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.29716954588585553	[326]	[381,322,662,512]	5	hSpCas9	negative selection	8544584
67891533	67891556	10	+	27260156	RDES	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	-0.08244059750363614	[629]	[613,586,543,1044]	-1	hSpCas9	negative selection	8544585
67908068	67908091	10	-	27260156	RDES	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	0.1465446136785733	[1084]	[985,1357,1348,1968]	2	hSpCas9	negative selection	8544586
67908087	67908110	10	+	27260156	PC3	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.34042519186209363	[909]	[825,1169,1644,1158]	7	hSpCas9	negative selection	8601581
67906899	67906922	10	+	27260156	PC3	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.4066482506906064	[224]	[72,311,129,166]	-7	hSpCas9	negative selection	8601582
67906876	67906899	10	+	27260156	PC3	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.3872289552446784	[1049]	[393,796,1415,955]	-7	hSpCas9	negative selection	8601583
67891534	67891557	10	-	27260156	PC3	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.035081621844309074	[326]	[168,354,586,368]	0	hSpCas9	negative selection	8665835
67891533	67891556	10	+	27260156	PC3	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.058445273377199236	[629]	[489,575,824,798]	1	hSpCas9	negative selection	8665836
67908068	67908091	10	-	27260156	PC3	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.32348373304246925	[1084]	[558,889,1559,759]	-6	hSpCas9	negative selection	8665837
67908087	67908110	10	+	27260156	PATU8988T	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.3198742501429701	[909]	[694,747,549,841]	-5	hSpCas9	negative selection	8722832
67906899	67906922	10	+	27260156	PATU8988T	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.07658269195693457	[224]	[152,201,188,286]	-1	hSpCas9	negative selection	8722833
67906876	67906899	10	+	27260156	PATU8988T	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.6256712831359829	[1049]	[636,681,631,683]	-7	hSpCas9	negative selection	8722834
67891534	67891557	10	-	27260156	PATU8988T	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.42220612557863746	[326]	[285,421,222,794]	7	hSpCas9	negative selection	8787086
67891533	67891556	10	+	27260156	PATU8988T	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.02136923311485428	[629]	[730,605,463,675]	0	hSpCas9	negative selection	8787087
67908068	67908091	10	-	27260156	PATU8988T	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.2861170168242706	[1084]	[985,699,818,924]	-5	hSpCas9	negative selection	8787088
67908087	67908110	10	+	27260156	T47D	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.09394187262209419	[909]	[1145,942,925,962]	-2	hSpCas9	negative selection	8844083
67906899	67906922	10	+	27260156	T47D	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.33984248614607604	[224]	[193,161,212,264]	-6	hSpCas9	negative selection	8844084
67906876	67906899	10	+	27260156	T47D	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.36793425320673456	[1049]	[982,840,953,1024]	-7	hSpCas9	negative selection	8844085
67891534	67891557	10	-	27260156	T47D	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.2916945310113125	[326]	[473,364,472,564]	6	hSpCas9	negative selection	8908337
67891533	67891556	10	+	27260156	T47D	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.2196720647162682	[629]	[871,817,860,870]	5	hSpCas9	negative selection	8908338
67908068	67908091	10	-	27260156	T47D	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.055301327560638436	[1084]	[1134,1268,1141,1318]	-1	hSpCas9	negative selection	8908339
67908087	67908110	10	+	27260156	SU8686	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.2064971176336331	[909]	[993,832,1153,1243]	3	hSpCas9	negative selection	8965334
67906899	67906922	10	+	27260156	SU8686	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	0.4876783719216671	[224]	[358,268,140,506]	7	hSpCas9	negative selection	8965335
67906876	67906899	10	+	27260156	SU8686	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.10340460316413158	[1049]	[1178,1007,1123,1169]	1	hSpCas9	negative selection	8965336
67891534	67891557	10	-	27260156	SU8686	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.07584359497691795	[326]	[298,284,345,466]	1	hSpCas9	negative selection	9029588
67891533	67891556	10	+	27260156	SU8686	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.4156076951616571	[629]	[718,622,909,1171]	7	hSpCas9	negative selection	9029589
67908068	67908091	10	-	27260156	SU8686	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.06649132117691114	[1084]	[890,915,1112,1249]	-1	hSpCas9	negative selection	9029590
67908087	67908110	10	+	27260156	SKES1	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.17178901096550225	[909]	[825,934,792,692]	-4	hSpCas9	negative selection	9086585
67906899	67906922	10	+	27260156	SKES1	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.3616659983353854	[224]	[110,233,225,128]	-7	hSpCas9	negative selection	9086586
67906876	67906899	10	+	27260156	SKES1	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.4896814343035989	[1049]	[805,754,604,812]	-8	hSpCas9	negative selection	9086587
67891534	67891557	10	-	27260156	SKES1	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	-0.07400617115291541	[326]	[332,373,301,245]	-2	hSpCas9	negative selection	9150839
67891533	67891556	10	+	27260156	SKES1	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.08494700926406229	[629]	[668,812,603,599]	1	hSpCas9	negative selection	9150840
67908068	67908091	10	-	27260156	SKES1	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.05860948332847471	[1084]	[1018,1250,976,934]	-1	hSpCas9	negative selection	9150841
67908087	67908110	10	+	27260156	TOV112D	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	0.24466157644817843	[909]	[1293,1861,685,696]	5	hSpCas9	negative selection	9207836
67906899	67906922	10	+	27260156	TOV112D	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.3752289855845823	[224]	[230,125,129,199]	-6	hSpCas9	negative selection	9207837
67906876	67906899	10	+	27260156	TOV112D	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.11292728086846404	[1049]	[1146,1125,851,819]	-2	hSpCas9	negative selection	9207838
67891534	67891557	10	-	27260156	TOV112D	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.16030857126234938	[326]	[366,298,306,470]	3	hSpCas9	negative selection	9272090
67891533	67891556	10	+	27260156	TOV112D	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.1628600578957572	[629]	[461,1019,657,739]	3	hSpCas9	negative selection	9272091
67908068	67908091	10	-	27260156	TOV112D	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.16762569789716886	[1084]	[957,1213,781,973]	-3	hSpCas9	negative selection	9272092
67908087	67908110	10	+	27260156	TC71	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.25007481201710835	[909]	[738,854,847,840]	-6	hSpCas9	negative selection	9329087
67906899	67906922	10	+	27260156	TC71	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.1837523263139802	[224]	[132,237,209,273]	-5	hSpCas9	negative selection	9329088
67906876	67906899	10	+	27260156	TC71	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.4870513827177688	[1049]	[835,796,768,810]	-8	hSpCas9	negative selection	9329089
67891534	67891557	10	-	27260156	TC71	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.20228960853883465	[326]	[414,344,421,431]	5	hSpCas9	negative selection	9393341
67891533	67891556	10	+	27260156	TC71	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	-0.043039724078785646	[629]	[661,519,785,648]	-1	hSpCas9	negative selection	9393342
67908068	67908091	10	-	27260156	TC71	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.18772208523776257	[1084]	[980,906,1026,1179]	-5	hSpCas9	negative selection	9393343
67908087	67908110	10	+	27260156	TC32	viability	GTTGACTGTGAAGCTGTACGAGG	SIRT1	ENSG00000096717	-0.18567025376092994	[909]	[835,449,881,931]	-3	hSpCas9	negative selection	9450338
67906899	67906922	10	+	27260156	TC32	viability	AACAGGTTGCGGGAATCCAAAGG	SIRT1	ENSG00000096717	-0.22270391957211455	[224]	[154,186,176,194]	-4	hSpCas9	negative selection	9450339
67906876	67906899	10	+	27260156	TC32	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.09713420179984933	[1049]	[723,888,1105,985]	-2	hSpCas9	negative selection	9450340
67891534	67891557	10	-	27260156	TC32	viability	ACCTTTGCAAACTTGAAGAATGG	SIRT1	ENSG00000096717	0.593933136679601	[326]	[394,427,438,588]	8	hSpCas9	negative selection	9514592
67891533	67891556	10	+	27260156	TC32	viability	ACCATTCTTCAAGTTTGCAAAGG	SIRT1	ENSG00000096717	0.0798000281515221	[629]	[749,416,664,706]	1	hSpCas9	negative selection	9514593
67908068	67908091	10	-	27260156	TC32	viability	CAACTTTGTATTTACAAATCAGG	SIRT1	ENSG00000096717	-0.007646606632371711	[1084]	[877,722,1395,1205]	0	hSpCas9	negative selection	9514594
67884712	67884735	10	+	27869803	HPAFII	viability after 27 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.5723302336166639	[505]	[245,122,NaN]	-4	hSpCas9	negative selection	9538313
67884837	67884860	10	+	27869803	HPAFII	viability after 27 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-1.3735890803448614	[68]	[13,13,NaN]	-7	hSpCas9	negative selection	9538314
67891458	67891481	10	-	27869803	HPAFII	viability after 27 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	0.12301334968971886	[234]	[157,114,NaN]	1	hSpCas9	negative selection	9538315
67906876	67906899	10	+	27869803	HPAFII	viability after 27 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.7100857992798235	[369]	[65,53,NaN]	-8	hSpCas9	negative selection	9538316
67912985	67913008	10	+	27869803	HPAFII	viability after 27 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	1.5671492857473301	[336]	[464,574,NaN]	9	hSpCas9	negative selection	9538317
67916305	67916328	10	-	27869803	HPAFII	viability after 27 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	1.2870917320712223	[185]	[452,59,NaN]	9	hSpCas9	negative selection	9538318
67884712	67884735	10	+	27869803	HPAFII	viability after 15 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-0.3986372215996721	[505]	[652,262,NaN]	-4	hSpCas9	negative selection	9620762
67884837	67884860	10	+	27869803	HPAFII	viability after 15 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-0.10960027595780764	[68]	[48,80,NaN]	-1	hSpCas9	negative selection	9620763
67891458	67891481	10	-	27869803	HPAFII	viability after 15 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	0.3678068254080107	[234]	[529,198,NaN]	4	hSpCas9	negative selection	9620764
67906876	67906899	10	+	27869803	HPAFII	viability after 15 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.6648890331540558	[369]	[383,167,NaN]	-6	hSpCas9	negative selection	9620765
67912985	67913008	10	+	27869803	HPAFII	viability after 15 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.9400700342795076	[336]	[980,516,NaN]	8	hSpCas9	negative selection	9620766
67916305	67916328	10	-	27869803	HPAFII	viability after 15 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	0.5823426256787076	[185]	[532,153,NaN]	6	hSpCas9	negative selection	9620767
67884712	67884735	10	+	27869803	ASPC1	viability after 36 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	0.12528065545011247	[1263]	[418,630,400]	1	hSpCas9	negative selection	9703211
67884837	67884860	10	+	27869803	ASPC1	viability after 36 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	1.787972283565453	[123]	[306,120,59]	9	hSpCas9	negative selection	9703212
67891458	67891481	10	-	27869803	ASPC1	viability after 36 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	1.121943960611293	[689]	[550,935,172]	9	hSpCas9	negative selection	9703213
67906876	67906899	10	+	27869803	ASPC1	viability after 36 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.13960433250000223	[720]	[280,160,363]	1	hSpCas9	negative selection	9703214
67912985	67913008	10	+	27869803	ASPC1	viability after 36 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	0.8453621770294456	[950]	[882,641,352]	7	hSpCas9	negative selection	9703215
67916305	67916328	10	-	27869803	ASPC1	viability after 36 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.6358239031290407	[617]	[113,159,137]	-6	hSpCas9	negative selection	9703216
67884712	67884735	10	+	27869803	PATU8988S	viability after 35 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	0.04538888026995036	[983]	[615,200,NaN]	0	hSpCas9	negative selection	9785660
67884837	67884860	10	+	27869803	PATU8988S	viability after 35 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-0.5635669448872112	[195]	[14,91,NaN]	-5	hSpCas9	negative selection	9785661
67891458	67891481	10	-	27869803	PATU8988S	viability after 35 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	0.5905721003153265	[519]	[476,152,NaN]	6	hSpCas9	negative selection	9785662
67906876	67906899	10	+	27869803	PATU8988S	viability after 35 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.8467274504407815	[696]	[195,115,NaN]	-7	hSpCas9	negative selection	9785663
67912985	67913008	10	+	27869803	PATU8988S	viability after 35 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	-0.38566093699752446	[875]	[291,247,NaN]	-4	hSpCas9	negative selection	9785664
67916305	67916328	10	-	27869803	PATU8988S	viability after 35 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	-0.06405109536507708	[401]	[99,209,NaN]	0	hSpCas9	negative selection	9785665
67884712	67884735	10	+	27869803	PATU8988S	viability after 31 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	0.019146379636417632	[983]	[423,363,NaN]	0	hSpCas9	negative selection	9868109
67884837	67884860	10	+	27869803	PATU8988S	viability after 31 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-2.5747762542278725	[195]	[2,25,NaN]	-9	hSpCas9	negative selection	9868110
67891458	67891481	10	-	27869803	PATU8988S	viability after 31 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	0.41683733052868477	[519]	[311,231,NaN]	5	hSpCas9	negative selection	9868111
67906876	67906899	10	+	27869803	PATU8988S	viability after 31 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.0255388879566558	[696]	[154,112,NaN]	-7	hSpCas9	negative selection	9868112
67912985	67913008	10	+	27869803	PATU8988S	viability after 31 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	-0.4673966588264976	[875]	[238,269,NaN]	-5	hSpCas9	negative selection	9868113
67916305	67916328	10	-	27869803	PATU8988S	viability after 31 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	0.4126417619552228	[401]	[76,386,NaN]	5	hSpCas9	negative selection	9868114
67884712	67884735	10	+	27869803	HPAFII	viability after 35 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-1.5569786965712415	[505]	[87,85,NaN]	-7	hSpCas9	negative selection	9950558
67884837	67884860	10	+	27869803	HPAFII	viability after 35 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-0.5067306134578393	[68]	[17,31,NaN]	-3	hSpCas9	negative selection	9950559
67891458	67891481	10	-	27869803	HPAFII	viability after 35 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-0.10887577426276922	[234]	[162,50,NaN]	0	hSpCas9	negative selection	9950560
67906876	67906899	10	+	27869803	HPAFII	viability after 35 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-2.5784538000686665	[369]	[44,15,NaN]	-8	hSpCas9	negative selection	9950561
67912985	67913008	10	+	27869803	HPAFII	viability after 35 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	2.0507436527287037	[336]	[402,1048,NaN]	9	hSpCas9	negative selection	9950562
67916305	67916328	10	-	27869803	HPAFII	viability after 35 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	1.7143374060905388	[185]	[522,67,NaN]	9	hSpCas9	negative selection	9950563
67884712	67884735	10	+	27869803	HPAFII	viability after 31 days	CAGTTGGAAGATGGCGGACGAGG	SIRT1	ENSG00000096717	-1.2429894265298702	[505]	[152,83,NaN]	-6	hSpCas9	negative selection	10033007
67884837	67884860	10	+	27869803	HPAFII	viability after 31 days	GAGATGGTCCCGGCCTCGAGCGG	SIRT1	ENSG00000096717	-0.5766966252409209	[68]	[13,38,NaN]	-4	hSpCas9	negative selection	10033008
67891458	67891481	10	-	27869803	HPAFII	viability after 31 days	GATCTGGGAAGTCTACAGCAAGG	SIRT1	ENSG00000096717	-0.6344824034585044	[234]	[83,85,NaN]	-4	hSpCas9	negative selection	10033009
67906876	67906899	10	+	27869803	HPAFII	viability after 31 days	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-2.8818494414081095	[369]	[31,23,NaN]	-8	hSpCas9	negative selection	10033010
67912985	67913008	10	+	27869803	HPAFII	viability after 31 days	CTGGCCTAATAGAGTGGCAAAGG	SIRT1	ENSG00000096717	1.4037249910792717	[336]	[341,672,NaN]	9	hSpCas9	negative selection	10033011
67916305	67916328	10	-	27869803	HPAFII	viability after 31 days	CTGAATATACCTCAGCGCCATGG	SIRT1	ENSG00000096717	1.281029613788131	[185]	[424,66,NaN]	8	hSpCas9	negative selection	10033012
67912707	67912730	10	-	28162770	P31FUJ	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	0.2581841480977638	[36]	[51]	2	hSpCas9	negative selection	10234466
67912518	67912541	10	-	28162770	P31FUJ	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.7280979758966812	[560]	[1091]	8	hSpCas9	negative selection	10234467
67912752	67912775	10	-	28162770	P31FUJ	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	0.21211233619908082	[226]	[308]	2	hSpCas9	negative selection	10234468
67906835	67906858	10	+	28162770	P31FUJ	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-0.20109334468704043	[89]	[91]	-2	hSpCas9	negative selection	10234469
67909390	67909413	10	-	28162770	P31FUJ	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	0.19461901932029768	[86]	[116]	2	hSpCas9	negative selection	10234470
67912979	67913002	10	+	28162770	P31FUJ	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	0.05619399528337024	[256]	[313]	0	hSpCas9	negative selection	10234471
67906876	67906899	10	+	28162770	P31FUJ	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.6058456150285954	[394]	[304]	-5	hSpCas9	negative selection	10234472
67913002	67913025	10	+	28162770	P31FUJ	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	0.14457944420481628	[785]	[1020]	1	hSpCas9	negative selection	10234473
67906888	67906911	10	+	28162770	P31FUJ	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.6770908793556633	[255]	[480]	7	hSpCas9	negative selection	10234474
67909262	67909285	10	-	28162770	P31FUJ	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	0.4017423251573379	[142]	[221]	4	hSpCas9	negative selection	10234475
67912707	67912730	10	-	28162770	TF1	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	NaN	[NaN]	[84]	1	hSpCas9	negative selection	10403832
67912518	67912541	10	-	28162770	TF1	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	NaN	[NaN]	[678]	1	hSpCas9	negative selection	10403833
67912752	67912775	10	-	28162770	TF1	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	NaN	[NaN]	[138]	1	hSpCas9	negative selection	10403834
67906835	67906858	10	+	28162770	TF1	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	NaN	[NaN]	[68]	1	hSpCas9	negative selection	10403835
67909390	67909413	10	-	28162770	TF1	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	NaN	[NaN]	[82]	1	hSpCas9	negative selection	10403836
67912979	67913002	10	+	28162770	TF1	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	NaN	[NaN]	[180]	1	hSpCas9	negative selection	10403837
67906876	67906899	10	+	28162770	TF1	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	NaN	[NaN]	[259]	1	hSpCas9	negative selection	10403838
67913002	67913025	10	+	28162770	TF1	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	NaN	[NaN]	[400]	1	hSpCas9	negative selection	10403839
67906888	67906911	10	+	28162770	TF1	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	NaN	[NaN]	[540]	1	hSpCas9	negative selection	10403840
67909262	67909285	10	-	28162770	TF1	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	NaN	[NaN]	[184]	1	hSpCas9	negative selection	10403841
67912707	67912730	10	-	28162770	SKM1	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-1.9000042100232788	[18]	[8]	-8	hSpCas9	negative selection	10573198
67912518	67912541	10	-	28162770	SKM1	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.4675049191729794	[161]	[395]	4	hSpCas9	negative selection	10573199
67912752	67912775	10	-	28162770	SKM1	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	-0.6245556338157883	[74]	[85]	-5	hSpCas9	negative selection	10573200
67906835	67906858	10	+	28162770	SKM1	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-0.262574289407987	[18]	[27]	-2	hSpCas9	negative selection	10573201
67909390	67909413	10	-	28162770	SKM1	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-1.6585029657391264	[24]	[13]	-8	hSpCas9	negative selection	10573202
67912979	67913002	10	+	28162770	SKM1	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	0.4440731621318392	[78]	[189]	4	hSpCas9	negative selection	10573203
67906876	67906899	10	+	28162770	SKM1	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.4160093383461687	[79]	[52]	-7	hSpCas9	negative selection	10573204
67913002	67913025	10	+	28162770	SKM1	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	0.23478432806957183	[136]	[284]	2	hSpCas9	negative selection	10573205
67906888	67906911	10	+	28162770	SKM1	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.3369018973290548	[72]	[162]	3	hSpCas9	negative selection	10573206
67909262	67909285	10	-	28162770	SKM1	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	-1.4386730584704996	[45]	[29]	-7	hSpCas9	negative selection	10573207
67912707	67912730	10	-	28162770	SKM1	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-1.9000042100232788	[18]	[8]	-8	hSpCas9	negative selection	10742564
67912518	67912541	10	-	28162770	SKM1	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.4675049191729794	[161]	[395]	4	hSpCas9	negative selection	10742565
67912752	67912775	10	-	28162770	SKM1	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	-0.6245556338157883	[74]	[85]	-5	hSpCas9	negative selection	10742566
67906835	67906858	10	+	28162770	SKM1	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-0.262574289407987	[18]	[27]	-2	hSpCas9	negative selection	10742567
67909390	67909413	10	-	28162770	SKM1	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-1.6585029657391264	[24]	[13]	-8	hSpCas9	negative selection	10742568
67912979	67913002	10	+	28162770	SKM1	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	0.4440731621318392	[78]	[189]	4	hSpCas9	negative selection	10742569
67906876	67906899	10	+	28162770	SKM1	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.4160093383461687	[79]	[52]	-7	hSpCas9	negative selection	10742570
67913002	67913025	10	+	28162770	SKM1	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	0.23478432806957183	[136]	[284]	2	hSpCas9	negative selection	10742571
67906888	67906911	10	+	28162770	SKM1	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.3369018973290548	[72]	[162]	3	hSpCas9	negative selection	10742572
67909262	67909285	10	-	28162770	SKM1	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	-1.4386730584704996	[45]	[29]	-7	hSpCas9	negative selection	10742573
67912707	67912730	10	-	28162770	PL21	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-0.40472244366954113	[72]	[23]	-3	hSpCas9	negative selection	10911930
67912518	67912541	10	-	28162770	PL21	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.6072501979965349	[364]	[241]	5	hSpCas9	negative selection	10911931
67912752	67912775	10	-	28162770	PL21	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	0.5021681519389775	[291]	[179]	4	hSpCas9	negative selection	10911932
67906835	67906858	10	+	28162770	PL21	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-0.9697853869529922	[98]	[21]	-6	hSpCas9	negative selection	10911933
67909390	67909413	10	-	28162770	PL21	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-1.5623610717840235	[94]	[13]	-7	hSpCas9	negative selection	10911934
67912979	67913002	10	+	28162770	PL21	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	0.6370918901966045	[293]	[198]	5	hSpCas9	negative selection	10911935
67906876	67906899	10	+	28162770	PL21	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.4656349318199333	[256]	[80]	-3	hSpCas9	negative selection	10911936
67913002	67913025	10	+	28162770	PL21	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	0.2672538103478572	[398]	[208]	2	hSpCas9	negative selection	10911937
67906888	67906911	10	+	28162770	PL21	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	-0.24646796379039332	[307]	[112]	-2	hSpCas9	negative selection	10911938
67909262	67909285	10	-	28162770	PL21	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	0.5049941960177411	[101]	[62]	4	hSpCas9	negative selection	10911939
67912707	67912730	10	-	28162770	P31FUJ	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	0.2581841480977638	[36]	[51]	2	hSpCas9	negative selection	11081296
67912518	67912541	10	-	28162770	P31FUJ	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.7280979758966812	[560]	[1091]	8	hSpCas9	negative selection	11081297
67912752	67912775	10	-	28162770	P31FUJ	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	0.21211233619908082	[226]	[308]	2	hSpCas9	negative selection	11081298
67906835	67906858	10	+	28162770	P31FUJ	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-0.20109334468704043	[89]	[91]	-2	hSpCas9	negative selection	11081299
67909390	67909413	10	-	28162770	P31FUJ	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	0.19461901932029768	[86]	[116]	2	hSpCas9	negative selection	11081300
67912979	67913002	10	+	28162770	P31FUJ	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	0.05619399528337024	[256]	[313]	0	hSpCas9	negative selection	11081301
67906876	67906899	10	+	28162770	P31FUJ	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.6058456150285954	[394]	[304]	-5	hSpCas9	negative selection	11081302
67913002	67913025	10	+	28162770	P31FUJ	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	0.14457944420481628	[785]	[1020]	1	hSpCas9	negative selection	11081303
67906888	67906911	10	+	28162770	P31FUJ	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.6770908793556633	[255]	[480]	7	hSpCas9	negative selection	11081304
67909262	67909285	10	-	28162770	P31FUJ	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	0.4017423251573379	[142]	[221]	4	hSpCas9	negative selection	11081305
67912707	67912730	10	-	28162770	OCIAML5	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-0.9940855757364246	[31]	[28]	-6	hSpCas9	negative selection	11250662
67912518	67912541	10	-	28162770	OCIAML5	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.7718671613699915	[279]	[862]	6	hSpCas9	negative selection	11250663
67912752	67912775	10	-	28162770	OCIAML5	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	0.1698926817121431	[162]	[330]	1	hSpCas9	negative selection	11250664
67906835	67906858	10	+	28162770	OCIAML5	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-0.22962936472417772	[75]	[116]	-2	hSpCas9	negative selection	11250665
67909390	67909413	10	-	28162770	OCIAML5	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-0.08653182450101993	[59]	[101]	0	hSpCas9	negative selection	11250666
67912979	67913002	10	+	28162770	OCIAML5	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	0.44859290726971407	[163]	[403]	4	hSpCas9	negative selection	11250667
67906876	67906899	10	+	28162770	OCIAML5	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.49615637654739975	[192]	[246]	-3	hSpCas9	negative selection	11250668
67913002	67913025	10	+	28162770	OCIAML5	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	1.066478210210445	[336]	[1273]	8	hSpCas9	negative selection	11250669
67906888	67906911	10	+	28162770	OCIAML5	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.376374895145256	[203]	[477]	3	hSpCas9	negative selection	11250670
67909262	67909285	10	-	28162770	OCIAML5	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	-2.063570676057709	[87]	[37]	-8	hSpCas9	negative selection	11250671
67912707	67912730	10	-	28162770	EOL1	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	1.5168898026572881	[129]	[195]	9	hSpCas9	negative selection	11420028
67912518	67912541	10	-	28162770	EOL1	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.3370696729305954	[573]	[381]	3	hSpCas9	negative selection	11420029
67912752	67912775	10	-	28162770	EOL1	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	0.039190337511657236	[398]	[215]	0	hSpCas9	negative selection	11420030
67906835	67906858	10	+	28162770	EOL1	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	1.1275347937343896	[138]	[159]	8	hSpCas9	negative selection	11420031
67909390	67909413	10	-	28162770	EOL1	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-1.162915069679805	[135]	[31]	-7	hSpCas9	negative selection	11420032
67912979	67913002	10	+	28162770	EOL1	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	-0.09194035121803446	[527]	[260]	0	hSpCas9	negative selection	11420033
67906876	67906899	10	+	28162770	EOL1	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	0.8112312480409054	[277]	[256]	7	hSpCas9	negative selection	11420034
67913002	67913025	10	+	28162770	EOL1	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	0.037879717158913806	[672]	[363]	0	hSpCas9	negative selection	11420035
67906888	67906911	10	+	28162770	EOL1	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.9542951149645869	[335]	[342]	7	hSpCas9	negative selection	11420036
67909262	67909285	10	-	28162770	EOL1	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	0.11487898367468385	[155]	[88]	1	hSpCas9	negative selection	11420037
67912707	67912730	10	-	28162770	MOLM13	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-2.2082210072347728	[146]	[22]	-7	hSpCas9	negative selection	11589394
67912518	67912541	10	-	28162770	MOLM13	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.6741741360293945	[578]	[667]	5	hSpCas9	negative selection	11589395
67912752	67912775	10	-	28162770	MOLM13	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	-0.6411823176028907	[411]	[190]	-4	hSpCas9	negative selection	11589396
67906835	67906858	10	+	28162770	MOLM13	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	0.5388559028987222	[118]	[124]	4	hSpCas9	negative selection	11589397
67909390	67909413	10	-	28162770	MOLM13	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	0.3819161584347258	[120]	[113]	3	hSpCas9	negative selection	11589398
67912979	67913002	10	+	28162770	MOLM13	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	0.827739959575695	[412]	[529]	6	hSpCas9	negative selection	11589399
67906876	67906899	10	+	28162770	MOLM13	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-3.0040984089598117	[576]	[51]	-8	hSpCas9	negative selection	11589400
67913002	67913025	10	+	28162770	MOLM13	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	0.3114069633512371	[680]	[610]	2	hSpCas9	negative selection	11589401
67906888	67906911	10	+	28162770	MOLM13	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.6336982745146595	[311]	[349]	5	hSpCas9	negative selection	11589402
67909262	67909285	10	-	28162770	MOLM13	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	0.2657839743531165	[152]	[132]	2	hSpCas9	negative selection	11589403
67912707	67912730	10	-	28162770	HEL	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-0.6051886814432286	[75]	[31]	-4	hSpCas9	negative selection	11758760
67912518	67912541	10	-	28162770	HEL	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.04991421350623049	[551]	[365]	0	hSpCas9	negative selection	11758761
67912752	67912775	10	-	28162770	HEL	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	-0.10294397926695836	[331]	[197]	0	hSpCas9	negative selection	11758762
67906835	67906858	10	+	28162770	HEL	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	0.1508857356706823	[89]	[63]	1	hSpCas9	negative selection	11758763
67909390	67909413	10	-	28162770	HEL	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-0.007074813070767405	[90]	[57]	0	hSpCas9	negative selection	11758764
67912979	67913002	10	+	28162770	HEL	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	0.5977149073143616	[357]	[346]	5	hSpCas9	negative selection	11758765
67906876	67906899	10	+	28162770	HEL	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.4227785789238507	[472]	[112]	-7	hSpCas9	negative selection	11758766
67913002	67913025	10	+	28162770	HEL	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	-0.20183298721202014	[588]	[327]	-1	hSpCas9	negative selection	11758767
67906888	67906911	10	+	28162770	HEL	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.10066214413237717	[347]	[238]	0	hSpCas9	negative selection	11758768
67909262	67909285	10	-	28162770	HEL	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	0.18705934822416714	[95]	[69]	1	hSpCas9	negative selection	11758769
67912707	67912730	10	-	28162770	MV411	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-0.698114665194848	[51]	[26]	-5	hSpCas9	negative selection	11928126
67912518	67912541	10	-	28162770	MV411	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.7688133682493292	[401]	[576]	7	hSpCas9	negative selection	11928127
67912752	67912775	10	-	28162770	MV411	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	-0.7462209223433981	[226]	[113]	-5	hSpCas9	negative selection	11928128
67906835	67906858	10	+	28162770	MV411	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	0.7280633916891959	[85]	[119]	6	hSpCas9	negative selection	11928129
67909390	67909413	10	-	28162770	MV411	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	0.7893313296120456	[67]	[98]	7	hSpCas9	negative selection	11928130
67912979	67913002	10	+	28162770	MV411	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	0.4592008305107131	[252]	[292]	4	hSpCas9	negative selection	11928131
67906876	67906899	10	+	28162770	MV411	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-1.2754032380305835	[249]	[86]	-7	hSpCas9	negative selection	11928132
67913002	67913025	10	+	28162770	MV411	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	0.3821150304539469	[510]	[560]	3	hSpCas9	negative selection	11928133
67906888	67906911	10	+	28162770	MV411	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.4340335840523661	[238]	[271]	4	hSpCas9	negative selection	11928134
67909262	67909285	10	-	28162770	MV411	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	1.7006101789483903	[83]	[229]	9	hSpCas9	negative selection	11928135
67912707	67912730	10	-	28162770	MONOMAC1	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-1.0550178421871261	[28]	[15]	-7	hSpCas9	negative selection	12097492
67912518	67912541	10	-	28162770	MONOMAC1	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.081563816163708	[337]	[409]	0	hSpCas9	negative selection	12097493
67912752	67912775	10	-	28162770	MONOMAC1	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	-0.7613890681054238	[138]	[93]	-6	hSpCas9	negative selection	12097494
67906835	67906858	10	+	28162770	MONOMAC1	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-1.9675550009367864	[57]	[16]	-8	hSpCas9	negative selection	12097495
67909390	67909413	10	-	28162770	MONOMAC1	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	1.6138070610779303	[58]	[206]	9	hSpCas9	negative selection	12097496
67912979	67913002	10	+	28162770	MONOMAC1	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	-0.5475340941436868	[203]	[159]	-4	hSpCas9	negative selection	12097497
67906876	67906899	10	+	28162770	MONOMAC1	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.8001466944909692	[119]	[78]	-6	hSpCas9	negative selection	12097498
67913002	67913025	10	+	28162770	MONOMAC1	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	-0.027651675386267227	[296]	[333]	0	hSpCas9	negative selection	12097499
67906888	67906911	10	+	28162770	MONOMAC1	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.8960725573319276	[134]	[287]	8	hSpCas9	negative selection	12097500
67909262	67909285	10	-	28162770	MONOMAC1	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	0.4506614090095651	[59]	[93]	4	hSpCas9	negative selection	12097501
67912707	67912730	10	-	28162770	OCIAML2	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-1.0035038148148632	[16]	[46]	-6	hSpCas9	negative selection	12266858
67912518	67912541	10	-	28162770	OCIAML2	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	0.7639785458039258	[62]	[592]	7	hSpCas9	negative selection	12266859
67912752	67912775	10	-	28162770	OCIAML2	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	-0.48924550340950834	[38]	[153]	-4	hSpCas9	negative selection	12266860
67906835	67906858	10	+	28162770	OCIAML2	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-0.7264687296717511	[19]	[66]	-5	hSpCas9	negative selection	12266861
67909390	67909413	10	-	28162770	OCIAML2	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	0.8401577120400006	[12]	[128]	7	hSpCas9	negative selection	12266862
67912979	67913002	10	+	28162770	OCIAML2	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	0.426176989637327	[66]	[498]	4	hSpCas9	negative selection	12266863
67906876	67906899	10	+	28162770	OCIAML2	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.40173474403109366	[45]	[192]	-3	hSpCas9	negative selection	12266864
67913002	67913025	10	+	28162770	OCIAML2	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	-0.04839682455911354	[99]	[535]	0	hSpCas9	negative selection	12266865
67906888	67906911	10	+	28162770	OCIAML2	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.06056141903801421	[40]	[236]	0	hSpCas9	negative selection	12266866
67909262	67909285	10	-	28162770	OCIAML2	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	-0.8665585015733004	[24]	[75]	-6	hSpCas9	negative selection	12266867
67912707	67912730	10	-	28162770	OCIAML3	viability	GAGTCTTCTGAAACATGAAGAGG	SIRT1	ENSG00000096717	-1.0579547400839535	[19]	[28]	-6	hSpCas9	negative selection	12436224
67912518	67912541	10	-	28162770	OCIAML3	viability	TCAAAATGCAGATGAGGCAAAGG	SIRT1	ENSG00000096717	-0.10152605561997097	[101]	[286]	-1	hSpCas9	negative selection	12436225
67912752	67912775	10	-	28162770	OCIAML3	viability	ACAATCACTGAAGAATCTGGTGG	SIRT1	ENSG00000096717	-1.1429008863377974	[78]	[107]	-7	hSpCas9	negative selection	12436226
67906835	67906858	10	+	28162770	OCIAML3	viability	ATAGCCTTGTCAGATAAGGAAGG	SIRT1	ENSG00000096717	-1.313899721131428	[27]	[33]	-7	hSpCas9	negative selection	12436227
67909390	67909413	10	-	28162770	OCIAML3	viability	GGGAAGACCCAATAACAATGAGG	SIRT1	ENSG00000096717	-0.07943446749440497	[13]	[39]	0	hSpCas9	negative selection	12436228
67912979	67913002	10	+	28162770	OCIAML3	viability	AAAATGCTGGCCTAATAGAGTGG	SIRT1	ENSG00000096717	-0.9246529523126346	[82]	[131]	-6	hSpCas9	negative selection	12436229
67906876	67906899	10	+	28162770	OCIAML3	viability	TACCCAGAACATAGACACGCTGG	SIRT1	ENSG00000096717	-0.8877388433808733	[75]	[123]	-6	hSpCas9	negative selection	12436230
67913002	67913025	10	+	28162770	OCIAML3	viability	CAAAGGAGCAGATTAGTAGGCGG	SIRT1	ENSG00000096717	-0.06865462874116224	[139]	[402]	0	hSpCas9	negative selection	12436231
67906888	67906911	10	+	28162770	OCIAML3	viability	AGACACGCTGGAACAGGTTGCGG	SIRT1	ENSG00000096717	0.1466057308571873	[78]	[263]	1	hSpCas9	negative selection	12436232
67909262	67909285	10	-	28162770	OCIAML3	viability	GCTGGGCACCTAGGACATCGAGG	SIRT1	ENSG00000096717	-0.338352764855967	[48]	[116]	-3	hSpCas9	negative selection	12436233