Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 4089
• Symbol: SMAD4
• Description: SMAD family member 4

DataSource: http://genomecrispr.dkfz.de/#!/results/SMAD4

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
51048724	51048747	18	-	26472758	Jiyoye	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	0.39190862485256295	[284]	[281]	3	hSpCas9	negative selection	151579
51048717	51048740	18	+	26472758	Jiyoye	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-0.2613104747775662	[239]	[150]	-2	hSpCas9	negative selection	151580
51054916	51054939	18	-	26472758	Jiyoye	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.256615704930492	[110]	[99]	2	hSpCas9	negative selection	151581
51058422	51058445	18	-	26472758	Jiyoye	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	5.407175381505873	[0]	[31]	9	hSpCas9	negative selection	151582
51058435	51058458	18	-	26472758	Jiyoye	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	0.5530262479693282	[93]	[103]	4	hSpCas9	negative selection	151583
51054931	51054954	18	-	26472758	Jiyoye	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.8986512533489202	[339]	[477]	6	hSpCas9	negative selection	151584
51065521	51065544	18	+	26472758	Jiyoye	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	-0.7303281422440615	[406]	[184]	-5	hSpCas9	negative selection	151585
51067076	51067099	18	+	26472758	Jiyoye	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.685083126346115	[451]	[211]	-5	hSpCas9	negative selection	151586
51067091	51067114	18	-	26472758	Jiyoye	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.28787645313352905	[125]	[115]	2	hSpCas9	negative selection	151587
51076725	51076748	18	+	26472758	Jiyoye	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.09721992828458709	[149]	[120]	0	hSpCas9	negative selection	151588
51048724	51048747	18	-	26472758	KBM7	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	-0.5203473063328102	[1147,893]	[292,366]	-4	hSpCas9	negative selection	342697
51048717	51048740	18	+	26472758	KBM7	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-0.6406290485149029	[391,486]	[74,187]	-5	hSpCas9	negative selection	342698
51054916	51054939	18	-	26472758	KBM7	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.1594295880378201	[477,361]	[189,243]	1	hSpCas9	negative selection	342699
51058422	51058445	18	-	26472758	KBM7	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	-0.008257035801384927	[40,67]	[30,21]	0	hSpCas9	negative selection	342700
51058435	51058458	18	-	26472758	KBM7	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	0.176718281517067	[478,326]	[199,220]	1	hSpCas9	negative selection	342701
51054931	51054954	18	-	26472758	KBM7	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	-0.013731014093451677	[1317,1113]	[710,432]	0	hSpCas9	negative selection	342702
51065521	51065544	18	+	26472758	KBM7	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	-0.8647393086738046	[782,910]	[127,304]	-6	hSpCas9	negative selection	342703
51067076	51067099	18	+	26472758	KBM7	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.3478137073790063	[1078,1014]	[396,378]	-3	hSpCas9	negative selection	342704
51067091	51067114	18	-	26472758	KBM7	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.03071803115456978	[296,368]	[179,133]	0	hSpCas9	negative selection	342705
51076725	51076748	18	+	26472758	KBM7	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.6142009835624123	[728,420]	[441,370]	6	hSpCas9	negative selection	342706
51048724	51048747	18	-	26472758	Raji	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	0.30613914782532303	[588]	[168]	3	hSpCas9	negative selection	533815
51048717	51048740	18	+	26472758	Raji	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.6571313435106978	[234]	[85]	6	hSpCas9	negative selection	533816
51054916	51054939	18	-	26472758	Raji	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.4327838221677669	[248]	[77]	4	hSpCas9	negative selection	533817
51058422	51058445	18	-	26472758	Raji	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	0.14802551987094548	[34]	[8]	1	hSpCas9	negative selection	533818
51058435	51058458	18	-	26472758	Raji	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	0.6790492134812978	[217]	[80]	6	hSpCas9	negative selection	533819
51054931	51054954	18	-	26472758	Raji	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.27626044738304567	[611]	[171]	2	hSpCas9	negative selection	533820
51065521	51065544	18	+	26472758	Raji	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	-0.11868454410624674	[654]	[139]	-1	hSpCas9	negative selection	533821
51067076	51067099	18	+	26472758	Raji	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.18538604737487274	[503]	[132]	1	hSpCas9	negative selection	533822
51067091	51067114	18	-	26472758	Raji	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.998154465618841	[191]	[88]	8	hSpCas9	negative selection	533823
51076725	51076748	18	+	26472758	Raji	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.6121756874107722	[295]	[104]	6	hSpCas9	negative selection	533824
51048724	51048747	18	-	26472758	K562	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	0.15398125641199645	[970]	[911]	1	hSpCas9	negative selection	724933
51048717	51048740	18	+	26472758	K562	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-0.2145493744878628	[388]	[282]	-1	hSpCas9	negative selection	724934
51054916	51054939	18	-	26472758	K562	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.06281192117649914	[278]	[245]	0	hSpCas9	negative selection	724935
51058422	51058445	18	-	26472758	K562	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	0.538149930723157	[61]	[75]	4	hSpCas9	negative selection	724936
51058435	51058458	18	-	26472758	K562	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	0.6700016973067342	[442]	[594]	5	hSpCas9	negative selection	724937
51054931	51054954	18	-	26472758	K562	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.8568981139732168	[1003]	[1534]	7	hSpCas9	negative selection	724938
51065521	51065544	18	+	26472758	K562	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	-0.11225460909840823	[871]	[680]	-1	hSpCas9	negative selection	724939
51067076	51067099	18	+	26472758	K562	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.2582813810481924	[724]	[731]	2	hSpCas9	negative selection	724940
51067091	51067114	18	-	26472758	K562	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.10491552456156733	[371]	[291]	0	hSpCas9	negative selection	724941
51076725	51076748	18	+	26472758	K562	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	-0.14986021144559947	[367]	[279]	-1	hSpCas9	negative selection	724942
51047090	51047113	18	-	26627737	DLD1	viability	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	0.21304417899309375	[619]	[213,209,245]	2	hSpCas9	negative selection	801682
51048717	51048740	18	+	26627737	DLD1	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-1.0157505040793804	[349]	[11,142,16]	-7	hSpCas9	negative selection	801683
51054933	51054956	18	-	26627737	DLD1	viability	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.07762930320733019	[282]	[69,145,69]	0	hSpCas9	negative selection	801684
51058339	51058362	18	+	26627737	DLD1	viability	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.6299615403187323	[319]	[76,72,46]	-6	hSpCas9	negative selection	801685
51067091	51067114	18	-	26627737	DLD1	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.25168591254105444	[369]	[28,193,75]	-3	hSpCas9	negative selection	801686
51076658	51076681	18	+	26627737	DLD1	viability	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	0.5768394436341324	[299]	[174,108,134]	6	hSpCas9	negative selection	801687
51047090	51047113	18	-	26627737	GBM cells	viability after 5 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.06667609432848307	[289]	[171,124]	-1	hSpCas9	negative selection	883997
51048717	51048740	18	+	26627737	GBM cells	viability after 5 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-0.4000530715583656	[186]	[81,69]	-6	hSpCas9	negative selection	883998
51054933	51054956	18	-	26627737	GBM cells	viability after 5 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.022545224054063118	[189]	[77,128]	0	hSpCas9	negative selection	883999
51058339	51058362	18	+	26627737	GBM cells	viability after 5 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	0.7125007506548042	[65]	[73,41]	8	hSpCas9	negative selection	884000
51067091	51067114	18	-	26627737	GBM cells	viability after 5 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.36505571511253543	[311]	[231,198]	5	hSpCas9	negative selection	884001
51076658	51076681	18	+	26627737	GBM cells	viability after 5 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	-0.3461986229508457	[255]	[138,76]	-5	hSpCas9	negative selection	884002
51047090	51047113	18	-	26627737	GBM cells	viability after 13 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.06397484899037797	[289]	[160,141]	-1	hSpCas9	negative selection	966312
51048717	51048740	18	+	26627737	GBM cells	viability after 13 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-1.7882743897441897	[186]	[19,36]	-9	hSpCas9	negative selection	966313
51054933	51054956	18	-	26627737	GBM cells	viability after 13 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.19919926380268727	[189]	[135,103]	2	hSpCas9	negative selection	966314
51058339	51058362	18	+	26627737	GBM cells	viability after 13 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	1.4655647153010034	[65]	[99,97]	9	hSpCas9	negative selection	966315
51067091	51067114	18	-	26627737	GBM cells	viability after 13 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.15759564547552507	[311]	[179,195]	2	hSpCas9	negative selection	966316
51076658	51076681	18	+	26627737	GBM cells	viability after 13 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	-0.6654739249204156	[255]	[134,48]	-7	hSpCas9	negative selection	966317
51047090	51047113	18	-	26627737	GBM cells	viability after 21 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.29043811645443907	[289]	[132,124]	-3	hSpCas9	negative selection	1048627
51048717	51048740	18	+	26627737	GBM cells	viability after 21 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-6.666661160271978	[186]	[0,0]	-9	hSpCas9	negative selection	1048628
51054933	51054956	18	-	26627737	GBM cells	viability after 21 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	-0.07246098560598496	[189]	[105,90]	0	hSpCas9	negative selection	1048629
51058339	51058362	18	+	26627737	GBM cells	viability after 21 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	1.2444755687621791	[65]	[85,83]	9	hSpCas9	negative selection	1048630
51067091	51067114	18	-	26627737	GBM cells	viability after 21 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.43746232245347433	[311]	[132,117]	-4	hSpCas9	negative selection	1048631
51076658	51076681	18	+	26627737	GBM cells	viability after 21 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	-2.666175960336105	[255]	[23,19]	-9	hSpCas9	negative selection	1048632
51047090	51047113	18	-	26627737	RPE1	viability after 9 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	0.48521474543850107	[523]	[264,183]	3	hSpCas9	negative selection	1130942
51048717	51048740	18	+	26627737	RPE1	viability after 9 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-0.19372311912532103	[383]	[67,152]	-1	hSpCas9	negative selection	1130943
51054933	51054956	18	-	26627737	RPE1	viability after 9 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.02567534992377407	[428]	[58,236]	0	hSpCas9	negative selection	1130944
51058339	51058362	18	+	26627737	RPE1	viability after 9 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-1.3553796702013243	[514]	[38,93]	-7	hSpCas9	negative selection	1130945
51067091	51067114	18	-	26627737	RPE1	viability after 9 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.665877068858398	[636]	[294,343]	4	hSpCas9	negative selection	1130946
51076658	51076681	18	+	26627737	RPE1	viability after 9 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	2.2155524953462646	[216]	[270,372]	9	hSpCas9	negative selection	1130947
51047090	51047113	18	-	26627737	RPE1	viability after 12 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	0.6810423311425489	[523]	[300,145]	4	hSpCas9	negative selection	1213257
51048717	51048740	18	+	26627737	RPE1	viability after 12 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.38061785920075164	[383]	[76,194]	2	hSpCas9	negative selection	1213258
51054933	51054956	18	-	26627737	RPE1	viability after 12 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	-0.31845544589150443	[428]	[55,130]	-2	hSpCas9	negative selection	1213259
51058339	51058362	18	+	26627737	RPE1	viability after 12 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-1.4334404544740345	[514]	[58,42]	-7	hSpCas9	negative selection	1213260
51067091	51067114	18	-	26627737	RPE1	viability after 12 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.39510939285546937	[636]	[209,240]	2	hSpCas9	negative selection	1213261
51076658	51076681	18	+	26627737	RPE1	viability after 12 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	1.4018819434655505	[216]	[155,151]	7	hSpCas9	negative selection	1213262
51047090	51047113	18	-	26627737	RPE1	viability after 15 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	0.47270164081652755	[523]	[278,134]	3	hSpCas9	negative selection	1295572
51048717	51048740	18	+	26627737	RPE1	viability after 15 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.6308319118101675	[383]	[184,151]	4	hSpCas9	negative selection	1295573
51054933	51054956	18	-	26627737	RPE1	viability after 15 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.5364022905720414	[428]	[259,94]	3	hSpCas9	negative selection	1295574
51058339	51058362	18	+	26627737	RPE1	viability after 15 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.1050366577999533	[514]	[109,159]	0	hSpCas9	negative selection	1295575
51067091	51067114	18	-	26627737	RPE1	viability after 15 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	1.0265290292296947	[636]	[390,343]	6	hSpCas9	negative selection	1295576
51076658	51076681	18	+	26627737	RPE1	viability after 15 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	2.1567875953519575	[216]	[260,285]	9	hSpCas9	negative selection	1295577
51047090	51047113	18	-	26627737	RPE1	viability after 18 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	0.754764265094066	[523]	[270,203]	4	hSpCas9	negative selection	1377887
51048717	51048740	18	+	26627737	RPE1	viability after 18 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.3134397095207646	[383]	[165,88]	2	hSpCas9	negative selection	1377888
51054933	51054956	18	-	26627737	RPE1	viability after 18 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	-0.22532558455955753	[428]	[99,97]	-1	hSpCas9	negative selection	1377889
51058339	51058362	18	+	26627737	RPE1	viability after 18 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-1.169535248112386	[514]	[40,83]	-6	hSpCas9	negative selection	1377890
51067091	51067114	18	-	26627737	RPE1	viability after 18 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.7504140686032755	[636]	[221,360]	4	hSpCas9	negative selection	1377891
51076658	51076681	18	+	26627737	RPE1	viability after 18 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	1.8052271004159295	[216]	[121,292]	8	hSpCas9	negative selection	1377892
51047090	51047113	18	-	26627737	HeLa	viability after 8 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.19395006932240275	[445]	[219,99,197]	-2	hSpCas9	negative selection	1460202
51048717	51048740	18	+	26627737	HeLa	viability after 8 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-0.8305662220157983	[361]	[158,59,63]	-7	hSpCas9	negative selection	1460203
51054933	51054956	18	-	26627737	HeLa	viability after 8 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	-0.31650320778573376	[370]	[124,134,127]	-3	hSpCas9	negative selection	1460204
51058339	51058362	18	+	26627737	HeLa	viability after 8 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.678571706987878	[196]	[20,26,101]	-6	hSpCas9	negative selection	1460205
51067091	51067114	18	-	26627737	HeLa	viability after 8 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.04989618829382153	[283]	[85,107,176]	0	hSpCas9	negative selection	1460206
51076658	51076681	18	+	26627737	HeLa	viability after 8 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	-0.12595807779323742	[431]	[124,321,66]	-1	hSpCas9	negative selection	1460207
51047090	51047113	18	-	26627737	HeLa	viability after 12 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.342944878084664	[445]	[108,134,191]	-3	hSpCas9	negative selection	1542517
51048717	51048740	18	+	26627737	HeLa	viability after 12 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-0.722970625718785	[361]	[54,79,136]	-6	hSpCas9	negative selection	1542518
51054933	51054956	18	-	26627737	HeLa	viability after 12 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	-0.20110167081382485	[370]	[150,110,140]	-2	hSpCas9	negative selection	1542519
51058339	51058362	18	+	26627737	HeLa	viability after 12 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.06903023745201597	[196]	[60,61,110]	0	hSpCas9	negative selection	1542520
51067091	51067114	18	-	26627737	HeLa	viability after 12 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.9058768909451139	[283]	[232,286,132]	7	hSpCas9	negative selection	1542521
51076658	51076681	18	+	26627737	HeLa	viability after 12 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	-0.012894716011724844	[431]	[268,209,50]	0	hSpCas9	negative selection	1542522
51047090	51047113	18	-	26627737	HeLa	viability after 15 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.40085152211404684	[445]	[195,75,139]	-3	hSpCas9	negative selection	1624832
51048717	51048740	18	+	26627737	HeLa	viability after 15 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-1.7351126929210643	[361]	[27,72,30]	-9	hSpCas9	negative selection	1624833
51054933	51054956	18	-	26627737	HeLa	viability after 15 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	-1.05908973337819	[370]	[46,131,35]	-7	hSpCas9	negative selection	1624834
51058339	51058362	18	+	26627737	HeLa	viability after 15 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.14542638857697177	[196]	[103,29,83]	-1	hSpCas9	negative selection	1624835
51067091	51067114	18	-	26627737	HeLa	viability after 15 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.17389201169215485	[283]	[85,64,249]	1	hSpCas9	negative selection	1624836
51076658	51076681	18	+	26627737	HeLa	viability after 15 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	-0.6037705495777422	[431]	[21,154,175]	-5	hSpCas9	negative selection	1624837
51047090	51047113	18	-	26627737	HeLa	viability after 18 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.4141455781626167	[445]	[132,57,139]	-4	hSpCas9	negative selection	1707147
51048717	51048740	18	+	26627737	HeLa	viability after 18 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-1.7408841234124794	[361]	[17,60,30]	-9	hSpCas9	negative selection	1707148
51054933	51054956	18	-	26627737	HeLa	viability after 18 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	-0.9987225260936451	[370]	[32,114,35]	-7	hSpCas9	negative selection	1707149
51058339	51058362	18	+	26627737	HeLa	viability after 18 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.11359257307499293	[196]	[71,25,83]	-1	hSpCas9	negative selection	1707150
51067091	51067114	18	-	26627737	HeLa	viability after 18 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.19444098816534716	[283]	[61,52,249]	1	hSpCas9	negative selection	1707151
51076658	51076681	18	+	26627737	HeLa	viability after 18 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	-0.6298746135043459	[431]	[14,122,175]	-5	hSpCas9	negative selection	1707152
51047090	51047113	18	-	26627737	HCT116	viability after 6 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	0.8979816926848149	[718]	[296,162]	5	hSpCas9	negative selection	1789462
51048717	51048740	18	+	26627737	HCT116	viability after 6 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-1.41853810382794	[427]	[68,0]	-7	hSpCas9	negative selection	1789463
51054933	51054956	18	-	26627737	HCT116	viability after 6 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.327872659953377	[311]	[145,14]	1	hSpCas9	negative selection	1789464
51058339	51058362	18	+	26627737	HCT116	viability after 6 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.1430336773143634	[501]	[191,4]	-1	hSpCas9	negative selection	1789465
51067091	51067114	18	-	26627737	HCT116	viability after 6 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-1.6509165981010885	[596]	[45,20]	-7	hSpCas9	negative selection	1789466
51076658	51076681	18	+	26627737	HCT116	viability after 6 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	1.1544313397707513	[232]	[203,13]	6	hSpCas9	negative selection	1789467
51047090	51047113	18	-	26627737	HCT116	viability after 8 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.7056138699431846	[560]	[194,204,168]	-7	hSpCas9	negative selection	1871777
51048717	51048740	18	+	26627737	HCT116	viability after 8 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.9149637720848514	[90]	[101,105,75]	8	hSpCas9	negative selection	1871778
51054933	51054956	18	-	26627737	HCT116	viability after 8 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.5044937002922625	[178]	[117,129,170]	5	hSpCas9	negative selection	1871779
51058339	51058362	18	+	26627737	HCT116	viability after 8 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.5235125637939011	[150]	[26,79,65]	-6	hSpCas9	negative selection	1871780
51067091	51067114	18	-	26627737	HCT116	viability after 8 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.5041711226745642	[337]	[201,126,66]	-6	hSpCas9	negative selection	1871781
51076658	51076681	18	+	26627737	HCT116	viability after 8 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	0.4582546561904365	[163]	[30,66,270]	5	hSpCas9	negative selection	1871782
51047090	51047113	18	-	26627737	HCT116	viability after 9 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.2727928627424781	[718]	[216,112]	-2	hSpCas9	negative selection	1954092
51048717	51048740	18	+	26627737	HCT116	viability after 9 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.43914402302198474	[427]	[40,244]	3	hSpCas9	negative selection	1954093
51054933	51054956	18	-	26627737	HCT116	viability after 9 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.5548986712504516	[311]	[194,64]	4	hSpCas9	negative selection	1954094
51058339	51058362	18	+	26627737	HCT116	viability after 9 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.6927676027101408	[501]	[116,55]	-5	hSpCas9	negative selection	1954095
51067091	51067114	18	-	26627737	HCT116	viability after 9 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.5466254802088131	[596]	[207,30]	-4	hSpCas9	negative selection	1954096
51076658	51076681	18	+	26627737	HCT116	viability after 9 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	2.3857392975047995	[232]	[194,427]	9	hSpCas9	negative selection	1954097
51047090	51047113	18	-	26627737	HCT116	viability after 12 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.20412755385332448	[560]	[340,119,295]	-2	hSpCas9	negative selection	2036407
51048717	51048740	18	+	26627737	HCT116	viability after 12 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.9235533026195213	[90]	[62,149,62]	7	hSpCas9	negative selection	2036408
51054933	51054956	18	-	26627737	HCT116	viability after 12 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	-0.06140813318136973	[178]	[102,76,88]	0	hSpCas9	negative selection	2036409
51058339	51058362	18	+	26627737	HCT116	viability after 12 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.1585879238896244	[150]	[83,64,62]	-2	hSpCas9	negative selection	2036410
51067091	51067114	18	-	26627737	HCT116	viability after 12 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.6410932314526596	[337]	[63,192,90]	-6	hSpCas9	negative selection	2036411
51076658	51076681	18	+	26627737	HCT116	viability after 12 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	0.4633940621308707	[163]	[98,108,149]	4	hSpCas9	negative selection	2036412
51047090	51047113	18	-	26627737	HCT116	viability after 15 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.2738135464638557	[560]	[302,242,257]	-3	hSpCas9	negative selection	2118722
51048717	51048740	18	+	26627737	HCT116	viability after 15 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.8717766282668681	[90]	[94,110,80]	7	hSpCas9	negative selection	2118723
51054933	51054956	18	-	26627737	HCT116	viability after 15 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	1.005495099887205	[178]	[279,132,214]	8	hSpCas9	negative selection	2118724
51058339	51058362	18	+	26627737	HCT116	viability after 15 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.14563971878003779	[150]	[69,72,90]	-1	hSpCas9	negative selection	2118725
51067091	51067114	18	-	26627737	HCT116	viability after 15 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.4363675565600417	[337]	[188,112,133]	-4	hSpCas9	negative selection	2118726
51076658	51076681	18	+	26627737	HCT116	viability after 15 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	0.571676207976455	[163]	[167,85,168]	5	hSpCas9	negative selection	2118727
51047090	51047113	18	-	26627737	HCT116	viability after 18 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	0.030326419114348968	[560]	[411,220,197]	0	hSpCas9	negative selection	2201037
51048717	51048740	18	+	26627737	HCT116	viability after 18 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.35847861932878855	[90]	[27,86,51]	3	hSpCas9	negative selection	2201038
51054933	51054956	18	-	26627737	HCT116	viability after 18 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.6736751979333367	[178]	[125,143,143]	5	hSpCas9	negative selection	2201039
51058339	51058362	18	+	26627737	HCT116	viability after 18 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	0.03397101114638168	[150]	[112,0,116]	0	hSpCas9	negative selection	2201040
51067091	51067114	18	-	26627737	HCT116	viability after 18 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.9132721828095108	[337]	[122,82,52]	-7	hSpCas9	negative selection	2201041
51076658	51076681	18	+	26627737	HCT116	viability after 18 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	0.3470624808959477	[163]	[68,32,209]	3	hSpCas9	negative selection	2201042
51047074	51047097	18	-	24336569	HL60	viability	AGACAGGCATCATTACTTGTTGG	SMAD4	ENSG00000141646	-0.24923450993226293	[919]	[1637]	-2	hSpCas9	negative selection	2295663
51047090	51047113	18	-	24336569	HL60	viability	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	0.25640553812748723	[107]	[272]	2	hSpCas9	negative selection	2295664
51047110	51047133	18	+	24336569	HL60	viability	AGTTTGATGTGCCATAGACAAGG	SMAD4	ENSG00000141646	-0.16980357529026824	[462]	[870]	-1	hSpCas9	negative selection	2295665
51047121	51047144	18	-	24336569	HL60	viability	CACTCTCTCCACCTTGTCTATGG	SMAD4	ENSG00000141646	-0.4455040681090588	[490]	[762]	-4	hSpCas9	negative selection	2295666
51047169	51047192	18	+	24336569	HL60	viability	AAGTTTGGTAAAGAAGCTGAAGG	SMAD4	ENSG00000141646	-2.908702447017049	[620]	[174]	-9	hSpCas9	negative selection	2295667
51047218	51047241	18	+	24336569	HL60	viability	ATAACAGCTATAACTACAAATGG	SMAD4	ENSG00000141646	2.254819287235536	[29]	[302]	9	hSpCas9	negative selection	2295668
51047248	51047271	18	-	24336569	HL60	viability	TGTATGGTAACACATTTACTAGG	SMAD4	ENSG00000141646	-0.8922973028261036	[570]	[650]	-7	hSpCas9	negative selection	2295669
51047259	51047282	18	+	24336569	HL60	viability	TGTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	0.34207773088511173	[147]	[396]	3	hSpCas9	negative selection	2295670
51047264	51047287	18	+	24336569	HL60	viability	CCATACAGAGAACATTGGATGGG	SMAD4	ENSG00000141646	1.2195550044954853	[277]	[1369]	8	hSpCas9	negative selection	2295671
51047274	51047297	18	+	24336569	HL60	viability	AACATTGGATGGGAGGCTTCAGG	SMAD4	ENSG00000141646	0.8121906678229283	[583]	[2169]	6	hSpCas9	negative selection	2295672
51047074	51047097	18	-	24336569	KBM7	viability	AGACAGGCATCATTACTTGTTGG	SMAD4	ENSG00000141646	-0.369814733395751	[956]	[2019]	-3	hSpCas9	negative selection	2362840
51047090	51047113	18	-	24336569	KBM7	viability	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-1.183163560316728	[173]	[208]	-7	hSpCas9	negative selection	2362841
51047110	51047133	18	+	24336569	KBM7	viability	AGTTTGATGTGCCATAGACAAGG	SMAD4	ENSG00000141646	-0.9283528469980673	[680]	[975]	-6	hSpCas9	negative selection	2362842
51047121	51047144	18	-	24336569	KBM7	viability	CACTCTCTCCACCTTGTCTATGG	SMAD4	ENSG00000141646	-1.1118892004170355	[625]	[789]	-7	hSpCas9	negative selection	2362843
51047169	51047192	18	+	24336569	KBM7	viability	AAGTTTGGTAAAGAAGCTGAAGG	SMAD4	ENSG00000141646	0.672160047725213	[155]	[677]	6	hSpCas9	negative selection	2362844
51047218	51047241	18	+	24336569	KBM7	viability	ATAACAGCTATAACTACAAATGG	SMAD4	ENSG00000141646	0.3771820021123373	[152]	[541]	3	hSpCas9	negative selection	2362845
51047248	51047271	18	-	24336569	KBM7	viability	TGTATGGTAACACATTTACTAGG	SMAD4	ENSG00000141646	-0.629159665192474	[333]	[588]	-5	hSpCas9	negative selection	2362846
51047259	51047282	18	+	24336569	KBM7	viability	TGTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	-0.5559553575936744	[151]	[281]	-4	hSpCas9	negative selection	2362847
51047264	51047287	18	+	24336569	KBM7	viability	CCATACAGAGAACATTGGATGGG	SMAD4	ENSG00000141646	-1.5872753945423197	[855]	[776]	-8	hSpCas9	negative selection	2362848
51047274	51047297	18	+	24336569	KBM7	viability	AACATTGGATGGGAGGCTTCAGG	SMAD4	ENSG00000141646	1.062538794631376	[299]	[1708]	8	hSpCas9	negative selection	2362849
51035446	51035469	18	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCAAGAGGATCACTTGAGCCCAG	SMAD4	ENSG00000141646	0.169734143386715	[57,44]	[12,10]	0	dCas9-VP64	positive selection	2416832
51062572	51062595	18	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCACTGCAACCTCCACCTCCAGG	SMAD4	ENSG00000141646	0.058421953785092295	[801,622]	[115,212]	0	dCas9-VP64	positive selection	2420375
51030049	51030072	18	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCAGATTCAGAGCCGCCCGCCGG	SMAD4	ENSG00000141646	2.163682586167508	[42,31]	[29,43]	7	dCas9-VP64	positive selection	2437764
51030100	51030123	18	+	25494202	A375	resistance to PLX-4720 (puromycin)	GAGCGACCCTCCCCGTCACTCGG	SMAD4	ENSG00000141646	0.06583744463760577	[148,93]	[18,35]	0	dCas9-VP64	positive selection	2437765
51030068	51030091	18	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCCTACAGGGCAGCGCCAGCCGG	SMAD4	ENSG00000141646	-0.9172680984732969	[44,147]	[13,7]	-5	dCas9-VP64	positive selection	2437766
51035446	51035469	18	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCAAGAGGATCACTTGAGCCCAG	SMAD4	ENSG00000141646	-0.04478500742304492	[42,58]	[7,21]	0	dCas9-VP64	positive selection	2512087
51062572	51062595	18	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCACTGCAACCTCCACCTCCAGG	SMAD4	ENSG00000141646	0.1281772646791315	[789,694]	[166,357]	1	dCas9-VP64	positive selection	2515630
51030049	51030072	18	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCAGATTCAGAGCCGCCCGCCGG	SMAD4	ENSG00000141646	0.024228564611003645	[25,98]	[9,29]	0	dCas9-VP64	positive selection	2533019
51030100	51030123	18	+	25494202	A375	resistance to PLX-4720 (zeocin)	GAGCGACCCTCCCCGTCACTCGG	SMAD4	ENSG00000141646	1.4912852382040835	[183,212]	[80,277]	8	dCas9-VP64	positive selection	2533020
51030068	51030091	18	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCCTACAGGGCAGCGCCAGCCGG	SMAD4	ENSG00000141646	-0.10292332669284132	[10,57]	[11,7]	-1	dCas9-VP64	positive selection	2533021
51047274	51047297	18	+	27260157	DLD1	viability	AACATTGGATGGGAGGCTTCAGG	SMAD4	ENSG00000141646	-0.271756242052087	[]	[]	-2	hSpCas9	negative selection	2576507
51047218	51047241	18	+	27260157	DLD1	viability	ATAACAGCTATAACTACAAATGG	SMAD4	ENSG00000141646	-0.334931919569482	[]	[]	-3	hSpCas9	negative selection	2576810
51047113	51047136	18	+	27260157	DLD1	viability	TTGATGTGCCATAGACAAGGTGG	SMAD4	ENSG00000141646	-1.03336350404454	[]	[]	-7	hSpCas9	negative selection	2581788
51048711	51048734	18	+	27260157	DLD1	viability	ATGTGATCTATGCCCGTCTCTGG	SMAD4	ENSG00000141646	-0.678514895409295	[]	[]	-5	hSpCas9	negative selection	2604308
51047121	51047144	18	-	27260157	DLD1	viability	CACTCTCTCCACCTTGTCTATGG	SMAD4	ENSG00000141646	-1.08281870386329	[]	[]	-7	hSpCas9	negative selection	2604847
51047090	51047113	18	-	27260157	DLD1	viability	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	0.119790793248577	[]	[]	3	hSpCas9	negative selection	2606576
51048723	51048746	18	-	27260157	DLD1	viability	ATCAGGCCACCTCCAGAGACGGG	SMAD4	ENSG00000141646	0.555362942743881	[]	[]	8	hSpCas9	negative selection	2613572
51047264	51047287	18	+	27260157	DLD1	viability	CCATACAGAGAACATTGGATGGG	SMAD4	ENSG00000141646	-0.478997634810817	[]	[]	-4	hSpCas9	negative selection	2616392
51054868	51054891	18	-	27260157	DLD1	viability	ATTACTTGGTGGATGCTGGATGG	SMAD4	ENSG00000141646	-0.670177623945133	[]	[]	-5	hSpCas9	negative selection	2618149
51047248	51047271	18	-	27260157	DLD1	viability	TGTATGGTAACACATTTACTAGG	SMAD4	ENSG00000141646	-0.862356168434073	[]	[]	-6	hSpCas9	negative selection	2620477
51047110	51047133	18	+	27260157	DLD1	viability	AGTTTGATGTGCCATAGACAAGG	SMAD4	ENSG00000141646	-0.373861163262212	[]	[]	-3	hSpCas9	negative selection	2620993
51054831	51054854	18	+	27260157	DLD1	viability	CAGCCATCGTTGTCCACTGAAGG	SMAD4	ENSG00000141646	-0.0199485163650557	[]	[]	0	hSpCas9	negative selection	2621618
51047074	51047097	18	-	27260157	DLD1	viability	AGACAGGCATCATTACTTGTTGG	SMAD4	ENSG00000141646	-0.740219668210437	[]	[]	-5	hSpCas9	negative selection	2621962
51054834	51054857	18	-	27260157	DLD1	viability	TGTCCTTCAGTGGACAACGATGG	SMAD4	ENSG00000141646	-0.13828095223495	[]	[]	-1	hSpCas9	negative selection	2622403
51048707	51048730	18	-	27260157	DLD1	viability	AGACGGGCATAGATCACATGAGG	SMAD4	ENSG00000141646	-0.20772775453964	[]	[]	-1	hSpCas9	negative selection	2644368
51048833	51048856	18	+	27260157	DLD1	viability	TACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	-0.440828906657721	[]	[]	-4	hSpCas9	negative selection	2647310
51047259	51047282	18	+	27260157	DLD1	viability	TGTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	-0.419255034088968	[]	[]	-3	hSpCas9	negative selection	2648905
51047169	51047192	18	+	27260157	DLD1	viability	AAGTTTGGTAAAGAAGCTGAAGG	SMAD4	ENSG00000141646	-1.15814571494706	[]	[]	-7	hSpCas9	negative selection	2649498
51047274	51047297	18	+	27260157	HT1080	viability	AACATTGGATGGGAGGCTTCAGG	SMAD4	ENSG00000141646	0.559696603430356	[]	[]	5	hSpCas9	negative selection	2652637
51047218	51047241	18	+	27260157	HT1080	viability	ATAACAGCTATAACTACAAATGG	SMAD4	ENSG00000141646	0.0170310046129513	[]	[]	0	hSpCas9	negative selection	2652940
51047113	51047136	18	+	27260157	HT1080	viability	TTGATGTGCCATAGACAAGGTGG	SMAD4	ENSG00000141646	-0.932554141367988	[]	[]	-8	hSpCas9	negative selection	2657918
51048711	51048734	18	+	27260157	HT1080	viability	ATGTGATCTATGCCCGTCTCTGG	SMAD4	ENSG00000141646	-0.384220079088252	[]	[]	-7	hSpCas9	negative selection	2680438
51047121	51047144	18	-	27260157	HT1080	viability	CACTCTCTCCACCTTGTCTATGG	SMAD4	ENSG00000141646	-0.72190430841568	[]	[]	-8	hSpCas9	negative selection	2680977
51047090	51047113	18	-	27260157	HT1080	viability	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	1.00282883317576	[]	[]	8	hSpCas9	negative selection	2682706
51048723	51048746	18	-	27260157	HT1080	viability	ATCAGGCCACCTCCAGAGACGGG	SMAD4	ENSG00000141646	0.0958703429793779	[]	[]	1	hSpCas9	negative selection	2689702
51047264	51047287	18	+	27260157	HT1080	viability	CCATACAGAGAACATTGGATGGG	SMAD4	ENSG00000141646	-0.436674744627749	[]	[]	-7	hSpCas9	negative selection	2692522
51054868	51054891	18	-	27260157	HT1080	viability	ATTACTTGGTGGATGCTGGATGG	SMAD4	ENSG00000141646	-0.0438498359573611	[]	[]	0	hSpCas9	negative selection	2694279
51047248	51047271	18	-	27260157	HT1080	viability	TGTATGGTAACACATTTACTAGG	SMAD4	ENSG00000141646	-0.662382931171553	[]	[]	-8	hSpCas9	negative selection	2696607
51047110	51047133	18	+	27260157	HT1080	viability	AGTTTGATGTGCCATAGACAAGG	SMAD4	ENSG00000141646	-0.275466656046133	[]	[]	-4	hSpCas9	negative selection	2697123
51054831	51054854	18	+	27260157	HT1080	viability	CAGCCATCGTTGTCCACTGAAGG	SMAD4	ENSG00000141646	0.042900551702479	[]	[]	0	hSpCas9	negative selection	2697748
51047074	51047097	18	-	27260157	HT1080	viability	AGACAGGCATCATTACTTGTTGG	SMAD4	ENSG00000141646	-0.0147870233627892	[]	[]	0	hSpCas9	negative selection	2698092
51054834	51054857	18	-	27260157	HT1080	viability	TGTCCTTCAGTGGACAACGATGG	SMAD4	ENSG00000141646	-0.404202885272684	[]	[]	-7	hSpCas9	negative selection	2698533
51048707	51048730	18	-	27260157	HT1080	viability	AGACGGGCATAGATCACATGAGG	SMAD4	ENSG00000141646	0.502850833540586	[]	[]	4	hSpCas9	negative selection	2720498
51048833	51048856	18	+	27260157	HT1080	viability	TACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	-0.171200825141265	[]	[]	0	hSpCas9	negative selection	2723440
51047259	51047282	18	+	27260157	HT1080	viability	TGTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	-0.179770952669222	[]	[]	0	hSpCas9	negative selection	2725035
51047169	51047192	18	+	27260157	HT1080	viability	AAGTTTGGTAAAGAAGCTGAAGG	SMAD4	ENSG00000141646	-0.350056958399912	[]	[]	-7	hSpCas9	negative selection	2725628
51047274	51047297	18	+	27260157	MKN45	viability	AACATTGGATGGGAGGCTTCAGG	SMAD4	ENSG00000141646	0.898019378225026	[]	[]	8	hSpCas9	negative selection	2728767
51047218	51047241	18	+	27260157	MKN45	viability	ATAACAGCTATAACTACAAATGG	SMAD4	ENSG00000141646	1.00419746772383	[]	[]	8	hSpCas9	negative selection	2729070
51047113	51047136	18	+	27260157	MKN45	viability	TTGATGTGCCATAGACAAGGTGG	SMAD4	ENSG00000141646	0.067468701889793	[]	[]	0	hSpCas9	negative selection	2734048
51048711	51048734	18	+	27260157	MKN45	viability	ATGTGATCTATGCCCGTCTCTGG	SMAD4	ENSG00000141646	0.0225144217757879	[]	[]	0	hSpCas9	negative selection	2756568
51047121	51047144	18	-	27260157	MKN45	viability	CACTCTCTCCACCTTGTCTATGG	SMAD4	ENSG00000141646	-0.311540372910111	[]	[]	-1	hSpCas9	negative selection	2757107
51047090	51047113	18	-	27260157	MKN45	viability	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	2.00200579961179	[]	[]	9	hSpCas9	negative selection	2758836
51048723	51048746	18	-	27260157	MKN45	viability	ATCAGGCCACCTCCAGAGACGGG	SMAD4	ENSG00000141646	1.73532045561275	[]	[]	9	hSpCas9	negative selection	2765832
51047264	51047287	18	+	27260157	MKN45	viability	CCATACAGAGAACATTGGATGGG	SMAD4	ENSG00000141646	0.396669279497807	[]	[]	6	hSpCas9	negative selection	2768652
51054868	51054891	18	-	27260157	MKN45	viability	ATTACTTGGTGGATGCTGGATGG	SMAD4	ENSG00000141646	0.755349523487225	[]	[]	7	hSpCas9	negative selection	2770409
51047248	51047271	18	-	27260157	MKN45	viability	TGTATGGTAACACATTTACTAGG	SMAD4	ENSG00000141646	1.22961424242745	[]	[]	9	hSpCas9	negative selection	2772737
51047110	51047133	18	+	27260157	MKN45	viability	AGTTTGATGTGCCATAGACAAGG	SMAD4	ENSG00000141646	0.0879074279182506	[]	[]	0	hSpCas9	negative selection	2773253
51054831	51054854	18	+	27260157	MKN45	viability	CAGCCATCGTTGTCCACTGAAGG	SMAD4	ENSG00000141646	0.998035396010338	[]	[]	8	hSpCas9	negative selection	2773878
51047074	51047097	18	-	27260157	MKN45	viability	AGACAGGCATCATTACTTGTTGG	SMAD4	ENSG00000141646	0.77651496887216	[]	[]	7	hSpCas9	negative selection	2774222
51054834	51054857	18	-	27260157	MKN45	viability	TGTCCTTCAGTGGACAACGATGG	SMAD4	ENSG00000141646	0.850547168871934	[]	[]	8	hSpCas9	negative selection	2774663
51048707	51048730	18	-	27260157	MKN45	viability	AGACGGGCATAGATCACATGAGG	SMAD4	ENSG00000141646	0.17524728642111	[]	[]	5	hSpCas9	negative selection	2796628
51048833	51048856	18	+	27260157	MKN45	viability	TACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	-0.012675716165714	[]	[]	0	hSpCas9	negative selection	2799570
51047259	51047282	18	+	27260157	MKN45	viability	TGTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	0.80868729807743	[]	[]	8	hSpCas9	negative selection	2801165
51047169	51047192	18	+	27260157	MKN45	viability	AAGTTTGGTAAAGAAGCTGAAGG	SMAD4	ENSG00000141646	1.09002203319575	[]	[]	8	hSpCas9	negative selection	2801758
51047274	51047297	18	+	27260157	RKO	viability	AACATTGGATGGGAGGCTTCAGG	SMAD4	ENSG00000141646	0.687119528021012	[]	[]	7	hSpCas9	negative selection	2804897
51047218	51047241	18	+	27260157	RKO	viability	ATAACAGCTATAACTACAAATGG	SMAD4	ENSG00000141646	0.289401196972412	[]	[]	1	hSpCas9	negative selection	2805200
51047113	51047136	18	+	27260157	RKO	viability	TTGATGTGCCATAGACAAGGTGG	SMAD4	ENSG00000141646	0.429392123786166	[]	[]	2	hSpCas9	negative selection	2810178
51048711	51048734	18	+	27260157	RKO	viability	ATGTGATCTATGCCCGTCTCTGG	SMAD4	ENSG00000141646	-0.0946991922647027	[]	[]	0	hSpCas9	negative selection	2832698
51047121	51047144	18	-	27260157	RKO	viability	CACTCTCTCCACCTTGTCTATGG	SMAD4	ENSG00000141646	0.394367971200908	[]	[]	2	hSpCas9	negative selection	2833237
51047090	51047113	18	-	27260157	RKO	viability	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	1.24878940697363	[]	[]	9	hSpCas9	negative selection	2834966
51048723	51048746	18	-	27260157	RKO	viability	ATCAGGCCACCTCCAGAGACGGG	SMAD4	ENSG00000141646	1.51525381516905	[]	[]	9	hSpCas9	negative selection	2841962
51047264	51047287	18	+	27260157	RKO	viability	CCATACAGAGAACATTGGATGGG	SMAD4	ENSG00000141646	-0.300768463290587	[]	[]	-6	hSpCas9	negative selection	2844782
51054868	51054891	18	-	27260157	RKO	viability	ATTACTTGGTGGATGCTGGATGG	SMAD4	ENSG00000141646	0.386134484243458	[]	[]	2	hSpCas9	negative selection	2846539
51047248	51047271	18	-	27260157	RKO	viability	TGTATGGTAACACATTTACTAGG	SMAD4	ENSG00000141646	0.162029664674831	[]	[]	0	hSpCas9	negative selection	2848867
51047110	51047133	18	+	27260157	RKO	viability	AGTTTGATGTGCCATAGACAAGG	SMAD4	ENSG00000141646	0.343716850892257	[]	[]	1	hSpCas9	negative selection	2849383
51054831	51054854	18	+	27260157	RKO	viability	CAGCCATCGTTGTCCACTGAAGG	SMAD4	ENSG00000141646	-0.0192649327534057	[]	[]	0	hSpCas9	negative selection	2850008
51047074	51047097	18	-	27260157	RKO	viability	AGACAGGCATCATTACTTGTTGG	SMAD4	ENSG00000141646	0.659848148097646	[]	[]	3	hSpCas9	negative selection	2850352
51054834	51054857	18	-	27260157	RKO	viability	TGTCCTTCAGTGGACAACGATGG	SMAD4	ENSG00000141646	-0.0314160655335994	[]	[]	0	hSpCas9	negative selection	2850793
51048707	51048730	18	-	27260157	RKO	viability	AGACGGGCATAGATCACATGAGG	SMAD4	ENSG00000141646	0.973983081157169	[]	[]	8	hSpCas9	negative selection	2872758
51048833	51048856	18	+	27260157	RKO	viability	TACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	0.122180985019375	[]	[]	0	hSpCas9	negative selection	2875700
51047259	51047282	18	+	27260157	RKO	viability	TGTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	0.156720187388157	[]	[]	0	hSpCas9	negative selection	2877295
51047169	51047192	18	+	27260157	RKO	viability	AAGTTTGGTAAAGAAGCTGAAGG	SMAD4	ENSG00000141646	-0.0387678033369603	[]	[]	0	hSpCas9	negative selection	2877888
51047274	51047297	18	+	27260157	SF268	viability	AACATTGGATGGGAGGCTTCAGG	SMAD4	ENSG00000141646	0.88906340300456	[]	[]	9	hSpCas9	negative selection	2881027
51047218	51047241	18	+	27260157	SF268	viability	ATAACAGCTATAACTACAAATGG	SMAD4	ENSG00000141646	1.11900968686948	[]	[]	9	hSpCas9	negative selection	2881330
51047113	51047136	18	+	27260157	SF268	viability	TTGATGTGCCATAGACAAGGTGG	SMAD4	ENSG00000141646	0.655129658313081	[]	[]	8	hSpCas9	negative selection	2886308
51048711	51048734	18	+	27260157	SF268	viability	ATGTGATCTATGCCCGTCTCTGG	SMAD4	ENSG00000141646	0.401800620880232	[]	[]	4	hSpCas9	negative selection	2908828
51047121	51047144	18	-	27260157	SF268	viability	CACTCTCTCCACCTTGTCTATGG	SMAD4	ENSG00000141646	0.543546335211002	[]	[]	8	hSpCas9	negative selection	2909367
51047090	51047113	18	-	27260157	SF268	viability	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	1.43276995274432	[]	[]	9	hSpCas9	negative selection	2911096
51048723	51048746	18	-	27260157	SF268	viability	ATCAGGCCACCTCCAGAGACGGG	SMAD4	ENSG00000141646	1.37065985307711	[]	[]	9	hSpCas9	negative selection	2918092
51047264	51047287	18	+	27260157	SF268	viability	CCATACAGAGAACATTGGATGGG	SMAD4	ENSG00000141646	1.03893857355024	[]	[]	9	hSpCas9	negative selection	2920912
51054868	51054891	18	-	27260157	SF268	viability	ATTACTTGGTGGATGCTGGATGG	SMAD4	ENSG00000141646	1.14207383460748	[]	[]	9	hSpCas9	negative selection	2922669
51047248	51047271	18	-	27260157	SF268	viability	TGTATGGTAACACATTTACTAGG	SMAD4	ENSG00000141646	0.451947081782957	[]	[]	7	hSpCas9	negative selection	2924997
51047110	51047133	18	+	27260157	SF268	viability	AGTTTGATGTGCCATAGACAAGG	SMAD4	ENSG00000141646	0.304364130604916	[]	[]	4	hSpCas9	negative selection	2925513
51054831	51054854	18	+	27260157	SF268	viability	CAGCCATCGTTGTCCACTGAAGG	SMAD4	ENSG00000141646	0.660999713595963	[]	[]	8	hSpCas9	negative selection	2926138
51047074	51047097	18	-	27260157	SF268	viability	AGACAGGCATCATTACTTGTTGG	SMAD4	ENSG00000141646	0.617436069968959	[]	[]	8	hSpCas9	negative selection	2926482
51054834	51054857	18	-	27260157	SF268	viability	TGTCCTTCAGTGGACAACGATGG	SMAD4	ENSG00000141646	0.973221487061485	[]	[]	9	hSpCas9	negative selection	2926923
51048707	51048730	18	-	27260157	SF268	viability	AGACGGGCATAGATCACATGAGG	SMAD4	ENSG00000141646	0.469064111710603	[]	[]	7	hSpCas9	negative selection	2948888
51048833	51048856	18	+	27260157	SF268	viability	TACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	0.053128359788963	[]	[]	0	hSpCas9	negative selection	2951830
51047259	51047282	18	+	27260157	SF268	viability	TGTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	1.10329197348057	[]	[]	9	hSpCas9	negative selection	2953425
51047169	51047192	18	+	27260157	SF268	viability	AAGTTTGGTAAAGAAGCTGAAGG	SMAD4	ENSG00000141646	1.4056123143694	[]	[]	9	hSpCas9	negative selection	2954018
51054916	51054939	18	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.19138927340117062	[3,3]	[2,3]	4	hSpCas9	positive selection	3022003
51058349	51058372	18	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGTCCTACTTCCAGTCCAGGTGG	SMAD4	ENSG00000141646	0.09331921261176901	[4,4]	[4,3]	2	hSpCas9	positive selection	3022004
51049304	51049327	18	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.19349986484564247	[3,3]	[2,2]	-3	hSpCas9	positive selection	3022005
51058153	51058176	18	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TCTGCAACAGTCCTTCACTATGG	SMAD4	ENSG00000141646	0.1444579510915528	[6,5]	[5,5]	3	hSpCas9	positive selection	3022006
51054916	51054939	18	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	-0.45874750693688565	[3,3]	[3,0]	-6	hSpCas9	positive selection	3089861
51058349	51058372	18	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGTCCTACTTCCAGTCCAGGTGG	SMAD4	ENSG00000141646	-0.07078908793034144	[4,4]	[4,2]	-1	hSpCas9	positive selection	3089862
51049304	51049327	18	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.1373580790251208	[3,3]	[2,1]	-2	hSpCas9	positive selection	3089863
51058153	51058176	18	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TCTGCAACAGTCCTTCACTATGG	SMAD4	ENSG00000141646	0.01153916178030312	[6,6]	[5,2]	0	hSpCas9	positive selection	3089864
51059905	51059928		-	24336571	A375	resistance to PLX after 7 days	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.26640157307715817	[14,9]	[10,8]	-7	hSpCas9	positive selection	3146056
51059895	51059918		+	24336571	A375	resistance to PLX after 7 days	CCTCCCATTTCCAATCATCCTGG	SMAD4	ENSG00000141646	0.036981068084154245	[10,10]	[11,11]	1	hSpCas9	positive selection	3146057
51049303	51049326		+	24336571	A375	resistance to PLX after 7 days	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.12044852816716956	[6,7]	[6,5]	-4	hSpCas9	positive selection	3146058
51059905	51059928		-	24336571	A375	resistance to PLX after 14 days	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.18104438132854705	[9,4]	[3,1]	-2	hSpCas9	positive selection	3203849
51059895	51059918		+	24336571	A375	resistance to PLX after 14 days	CCTCCCATTTCCAATCATCCTGG	SMAD4	ENSG00000141646	0.0002104230617981373	[10,6]	[3,3]	0	hSpCas9	positive selection	3203850
51049303	51049326		+	24336571	A375	resistance to PLX after 14 days	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.33064041646490533	[6,7]	[4,3]	3	hSpCas9	positive selection	3203851
51059905	51059928		-	24336571	A375	viability after 7 days	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.1685127459466998	[10]	[14,9]	2	hSpCas9	negative selection	3261642
51059895	51059918		+	24336571	A375	viability after 7 days	CCTCCCATTTCCAATCATCCTGG	SMAD4	ENSG00000141646	-0.7010931871380014	[19]	[10,10]	-7	hSpCas9	negative selection	3261643
51049303	51049326		+	24336571	A375	viability after 7 days	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.5891814119062925	[11]	[6,7]	-7	hSpCas9	negative selection	3261644
51059905	51059928		-	24336571	A375	viability after 14 days	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.4226951618143776	[10]	[9,4]	-5	hSpCas9	negative selection	3319435
51059895	51059918		+	24336571	A375	viability after 14 days	CCTCCCATTTCCAATCATCCTGG	SMAD4	ENSG00000141646	-1.0197623940954146	[19]	[10,6]	-8	hSpCas9	negative selection	3319436
51049303	51049326		+	24336571	A375	viability after 14 days	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.5375755800336707	[11]	[6,7]	-6	hSpCas9	negative selection	3319437
51049303	51049326	18	+	27383988	293T	resistance to West Nile virus (flavivirus)	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.36250844813789157	[118,118]	[0,0]	2	hSpCas9	positive selection	3393744
51059868	51059891	18	-	27383988	293T	resistance to West Nile virus (flavivirus)	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-1.164738554726977	[342,342]	[0,0]	-7	hSpCas9	positive selection	3393745
51067076	51067099	18	+	27383988	293T	resistance to West Nile virus (flavivirus)	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.327636289275321	[191,191]	[0,0]	-2	hSpCas9	positive selection	3393746
51054916	51054939	18	-	26780180	HT29	viability (Avana library 4 designs)	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	-0.528489073380212	[]	[]	-7	hSpCas9	negative selection	3460577
51058349	51058372	18	-	26780180	HT29	viability (Avana library 4 designs)	AGTCCTACTTCCAGTCCAGGTGG	SMAD4	ENSG00000141646	-0.382487854853387	[]	[]	-6	hSpCas9	negative selection	3460578
51049303	51049326	18	+	26780180	HT29	viability (Avana library 4 designs)	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	1.06791771593777	[]	[]	4	hSpCas9	negative selection	3460579
51058153	51058176	18	-	26780180	HT29	viability (Avana library 4 designs)	TCTGCAACAGTCCTTCACTATGG	SMAD4	ENSG00000141646	0.0340545830273619	[]	[]	0	hSpCas9	negative selection	3460580
51058349	51058372	18	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGTCCTACTTCCAGTCCAGGTGG	SMAD4	ENSG00000141646	3.01417036975612	[]	[]	4	hSpCas9	negative selection	3561021
51049303	51049326	18	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-4.94572688657119	[]	[]	-5	hSpCas9	negative selection	3561022
51058153	51058176	18	-	26780180	A375	viability (Avana lentiCRISPRv2)	TCTGCAACAGTCCTTCACTATGG	SMAD4	ENSG00000141646	-1.55187735914188	[]	[]	-2	hSpCas9	negative selection	3561023
51054916	51054939	18	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	2.07294582363355	[]	[]	3	hSpCas9	negative selection	3561024
51054879	51054902	18	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTCGATGCACGATTACTTGGTGG	SMAD4	ENSG00000141646	-3.14023409696364	[]	[]	-4	hSpCas9	negative selection	3561025
51058127	51058150	18	+	26780180	A375	viability (Avana lentiCRISPRv2)	CAGCCTGCCAGTATACTGGGGGG	SMAD4	ENSG00000141646	1.88739910316655	[]	[]	2	hSpCas9	negative selection	3561026
51058349	51058372	18	-	26780180	A375	viability (Avana lentiGuide)	AGTCCTACTTCCAGTCCAGGTGG	SMAD4	ENSG00000141646	-2.51777510427769	[]	[]	-4	hSpCas9	negative selection	3669680
51049303	51049326	18	+	26780180	A375	viability (Avana lentiGuide)	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-5.09900580528485	[]	[]	-8	hSpCas9	negative selection	3669681
51058153	51058176	18	-	26780180	A375	viability (Avana lentiGuide)	TCTGCAACAGTCCTTCACTATGG	SMAD4	ENSG00000141646	-1.91052174485605	[]	[]	-3	hSpCas9	negative selection	3669682
51054916	51054939	18	-	26780180	A375	viability (Avana lentiGuide)	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	4.32996258641268	[]	[]	4	hSpCas9	negative selection	3669683
51054879	51054902	18	-	26780180	A375	viability (Avana lentiGuide)	GTCGATGCACGATTACTTGGTGG	SMAD4	ENSG00000141646	1.68823871630875	[]	[]	2	hSpCas9	negative selection	3669684
51058127	51058150	18	+	26780180	A375	viability (Avana lentiGuide)	CAGCCTGCCAGTATACTGGGGGG	SMAD4	ENSG00000141646	-5.3485355011131	[]	[]	-8	hSpCas9	negative selection	3669685
51058349	51058372	18	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGTCCTACTTCCAGTCCAGGTGG	SMAD4	ENSG00000141646	0.26632798079972775	[5]	[7,6]	7	hSpCas9	positive selection	3778287
51049303	51049326	18	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.3530430907487066	[5]	[5,2]	-5	hSpCas9	positive selection	3778288
51058153	51058176	18	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCTGCAACAGTCCTTCACTATGG	SMAD4	ENSG00000141646	-0.03038988375660301	[7]	[7,5]	0	hSpCas9	positive selection	3778289
51054916	51054939	18	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.29146164431795174	[4]	[6,5]	8	hSpCas9	positive selection	3778290
51054879	51054902	18	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTCGATGCACGATTACTTGGTGG	SMAD4	ENSG00000141646	0.05962193086168341	[4]	[5,4]	1	hSpCas9	positive selection	3778291
51058127	51058150	18	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CAGCCTGCCAGTATACTGGGGGG	SMAD4	ENSG00000141646	0.27391438154015413	[4]	[5,5]	7	hSpCas9	positive selection	3778292
51058349	51058372	18	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGTCCTACTTCCAGTCCAGGTGG	SMAD4	ENSG00000141646	0.18906335372684577	[6]	[5,6]	4	hSpCas9	positive selection	3886894
51049303	51049326	18	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.30026482705401514	[5]	[5,4]	8	hSpCas9	positive selection	3886895
51058153	51058176	18	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCTGCAACAGTCCTTCACTATGG	SMAD4	ENSG00000141646	0.149920036252782	[7]	[7,6]	3	hSpCas9	positive selection	3886896
51054916	51054939	18	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.19985896989766905	[5]	[5,4]	5	hSpCas9	positive selection	3886897
51054879	51054902	18	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTCGATGCACGATTACTTGGTGG	SMAD4	ENSG00000141646	-0.17630242516064878	[5]	[5,2]	-2	hSpCas9	positive selection	3886898
51058127	51058150	18	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CAGCCTGCCAGTATACTGGGGGG	SMAD4	ENSG00000141646	0.3514089919652472	[5]	[6,4]	9	hSpCas9	positive selection	3886899
51067091	51067114	18	-	26780180	A375	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	1.43966574276285	[]	[]	8	hSpCas9	negative selection	3997006
51059905	51059928	18	-	26780180	A375	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.809408415475771	[]	[]	3	hSpCas9	negative selection	3997007
51059868	51059891	18	-	26780180	A375	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	1.31449912108885	[]	[]	7	hSpCas9	negative selection	3997008
51067076	51067099	18	+	26780180	A375	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	1.68147725519061	[]	[]	9	hSpCas9	negative selection	3997009
51049303	51049326	18	+	26780180	A375	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	1.17595144791624	[]	[]	6	hSpCas9	negative selection	3997010
51067008	51067031	18	+	26780180	A375	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	1.88562987480759	[]	[]	9	hSpCas9	negative selection	3997011
51067091	51067114	18	-	26780180	HT29	viability (GeCKOv2 library)	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	1.68790341226996	[]	[]	8	hSpCas9	negative selection	4104972
51059905	51059928	18	-	26780180	HT29	viability (GeCKOv2 library)	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.160373890739156	[]	[]	-4	hSpCas9	negative selection	4104973
51059868	51059891	18	-	26780180	HT29	viability (GeCKOv2 library)	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	1.16072781153566	[]	[]	5	hSpCas9	negative selection	4104974
51067076	51067099	18	+	26780180	HT29	viability (GeCKOv2 library)	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	1.76781910329384	[]	[]	8	hSpCas9	negative selection	4104975
51049303	51049326	18	+	26780180	HT29	viability (GeCKOv2 library)	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.992098246318036	[]	[]	4	hSpCas9	negative selection	4104976
51067008	51067031	18	+	26780180	HT29	viability (GeCKOv2 library)	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.384007278954901	[]	[]	1	hSpCas9	negative selection	4104977
51059905	51059928	18	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.18713596314878497	[3]	[2,1]	-4	hSpCas9	positive selection	4172131
51059895	51059918	18	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CCTCCCATTTCCAATCATCCTGG	SMAD4	ENSG00000141646	0.1065961785068968	[3]	[2,1]	2	hSpCas9	positive selection	4172132
51049303	51049326	18	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.16237966554619926	[2]	[0,1]	-4	hSpCas9	positive selection	4172133
51059905	51059928	18	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.6686596181684205	[4]	[1,2,0,3]	4	hSpCas9	positive selection	4236153
51059895	51059918	18	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CCTCCCATTTCCAATCATCCTGG	SMAD4	ENSG00000141646	-0.18076398307046154	[5]	[2,2,3,0]	-3	hSpCas9	positive selection	4236154
51049303	51049326	18	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.4438535164989256	[2]	[0,0,4,0]	3	hSpCas9	positive selection	4236155
51067091	51067114	18	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.45106219446194296	[2]	[3,1]	8	hSpCas9	positive selection	4299207
51067008	51067031	18	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.1633396652375519	[4]	[4,2]	3	hSpCas9	positive selection	4299208
51059905	51059928	18	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.16910965612451506	[4]	[4,2]	3	hSpCas9	positive selection	4299209
51049303	51049326	18	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.08929750706979334	[2]	[1,1]	-2	hSpCas9	positive selection	4363460
51059868	51059891	18	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.38016572954724825	[3]	[3,0]	-7	hSpCas9	positive selection	4363461
51067076	51067099	18	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.1407451041763108	[3]	[3,1]	3	hSpCas9	positive selection	4363462
51047260	51047282	18	+	27760321	OCIAML3	viability	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	0.9603626863600883	[33,34]	[50,54]	9	hSpCas9	negative selection	4441213
51048834	51048856	18	+	27760321	OCIAML3	viability	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	-0.20566318274010875	[228,186]	[89,205]	-2	hSpCas9	negative selection	4441214
51054872	51054894	18	-	27760321	OCIAML3	viability	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	0.5458720054527662	[890,819]	[901,1073]	6	hSpCas9	negative selection	4441215
51054931	51054953	18	-	27760321	OCIAML3	viability	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.349869932207314	[0,0]	[0,0]	4	hSpCas9	negative selection	4441216
51058226	51058248	18	-	27760321	OCIAML3	viability	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	0.07059498828301658	[58,47]	[54,28]	0	hSpCas9	negative selection	4441217
51047260	51047282	18	+	27760321	OCIAML2	viability	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	-0.30019705772682137	[33,34]	[14,32]	-4	hSpCas9	negative selection	4524676
51048834	51048856	18	+	27760321	OCIAML2	viability	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	0.15640555614301765	[228,186]	[224,135]	2	hSpCas9	negative selection	4524677
51054872	51054894	18	-	27760321	OCIAML2	viability	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	-0.161900291428418	[890,819]	[520,746]	-2	hSpCas9	negative selection	4524678
51054931	51054953	18	-	27760321	OCIAML2	viability	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.3011245669422653	[0,0]	[0,0]	4	hSpCas9	negative selection	4524679
51058226	51058248	18	-	27760321	OCIAML2	viability	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	-0.16705624114856432	[58,47]	[49,22]	-2	hSpCas9	negative selection	4524680
51047260	51047282	18	+	27760321	MV411	viability	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	-4.515285647787001	[33,34]	[0,0]	-9	hSpCas9	negative selection	4608139
51048834	51048856	18	+	27760321	MV411	viability	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	-0.11514352910509373	[228,186]	[0,313]	-1	hSpCas9	negative selection	4608140
51054872	51054894	18	-	27760321	MV411	viability	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	-0.0956501064517794	[890,819]	[606,409]	0	hSpCas9	negative selection	4608141
51054931	51054953	18	-	27760321	MV411	viability	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.5949485011219959	[0,0]	[0,0]	4	hSpCas9	negative selection	4608142
51058226	51058248	18	-	27760321	MV411	viability	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	-2.4128816900002796	[58,47]	[0,14]	-9	hSpCas9	negative selection	4608143
51047260	51047282	18	+	27760321	HL60	viability	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	-0.5575456667450833	[33,34]	[26,10]	-6	hSpCas9	negative selection	4691602
51048834	51048856	18	+	27760321	HL60	viability	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	-1.9820248799028872	[228,186]	[35,49]	-9	hSpCas9	negative selection	4691603
51054872	51054894	18	-	27760321	HL60	viability	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	-0.21280522413713043	[890,819]	[732,464]	-2	hSpCas9	negative selection	4691604
51054931	51054953	18	-	27760321	HL60	viability	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.2870783393278593	[0,0]	[0,0]	3	hSpCas9	negative selection	4691605
51058226	51058248	18	-	27760321	HL60	viability	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	-1.3448314927922453	[58,47]	[20,12]	-8	hSpCas9	negative selection	4691606
51047260	51047282	18	+	27760321	HT1080	viability	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	2.073114991727836	[34,27]	[60,43]	9	hSpCas9	negative selection	4775065
51048834	51048856	18	+	27760321	HT1080	viability	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	-5.084643895592714	[186,145]	[0,2]	-8	hSpCas9	negative selection	4775066
51054872	51054894	18	-	27760321	HT1080	viability	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	1.872600215529323	[819,639]	[1231,881]	8	hSpCas9	negative selection	4775067
51054931	51054953	18	-	27760321	HT1080	viability	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	1.3056276939190559	[0,0]	[0,0]	7	hSpCas9	negative selection	4775068
51058226	51058248	18	-	27760321	HT1080	viability	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	-2.339815341274893	[47,37]	[0,5]	-6	hSpCas9	negative selection	4775069
51047260	51047282	18	+	27760321	HT29	viability after 7 days	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	0.12709989713480763	[34,27]	[32,46,50]	2	hSpCas9	negative selection	4858528
51048834	51048856	18	+	27760321	HT29	viability after 7 days	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	-0.41925491083005384	[186,145]	[219,121,146]	-6	hSpCas9	negative selection	4858529
51054872	51054894	18	-	27760321	HT29	viability after 7 days	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	-0.4172653741403741	[819,639]	[615,962,521]	-6	hSpCas9	negative selection	4858530
51054931	51054953	18	-	27760321	HT29	viability after 7 days	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	-0.3840325596302083	[0,0]	[0,0,0]	-5	hSpCas9	negative selection	4858531
51058226	51058248	18	-	27760321	HT29	viability after 7 days	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	0.3006020090339523	[47,37]	[16,77,100]	4	hSpCas9	negative selection	4858532
51047260	51047282	18	+	27760321	HT29	viability after 25 days	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	0.5599028312533001	[34,27]	[65,26,66]	6	hSpCas9	negative selection	4941991
51048834	51048856	18	+	27760321	HT29	viability after 25 days	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	-0.7314643044209057	[186,145]	[84,89,176]	-6	hSpCas9	negative selection	4941992
51054872	51054894	18	-	27760321	HT29	viability after 25 days	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	-0.056038534569189835	[819,639]	[748,957,690]	0	hSpCas9	negative selection	4941993
51054931	51054953	18	-	27760321	HT29	viability after 25 days	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	-0.21405457092746794	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	4941994
51058226	51058248	18	-	27760321	HT29	viability after 25 days	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	-0.014462475029049404	[47,37]	[58,57,25]	0	hSpCas9	negative selection	4941995
51047260	51047282	18	+	27760321	HT29	viability after 22 days	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	-2.063879797396072	[34,27]	[13,5,5]	-8	hSpCas9	negative selection	5025454
51048834	51048856	18	+	27760321	HT29	viability after 22 days	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	-0.7594366875764653	[186,145]	[108,143,87]	-6	hSpCas9	negative selection	5025455
51054872	51054894	18	-	27760321	HT29	viability after 22 days	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	0.12331193112946615	[819,639]	[703,1186,871]	1	hSpCas9	negative selection	5025456
51054931	51054953	18	-	27760321	HT29	viability after 22 days	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	-0.23137320278672746	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	5025457
51058226	51058248	18	-	27760321	HT29	viability after 22 days	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	-0.6614866216039568	[47,37]	[10,43,39]	-5	hSpCas9	negative selection	5025458
51047260	51047282	18	+	27760321	HT29	viability after 19 days	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	-0.2812243686551663	[34,27]	[72,1,18]	-3	hSpCas9	negative selection	5108917
51048834	51048856	18	+	27760321	HT29	viability after 19 days	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	-0.17508797560263978	[186,145]	[103,303,93]	-2	hSpCas9	negative selection	5108918
51054872	51054894	18	-	27760321	HT29	viability after 19 days	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	0.1268265580062895	[819,639]	[801,855,1058]	1	hSpCas9	negative selection	5108919
51054931	51054953	18	-	27760321	HT29	viability after 19 days	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	-0.21553315036351428	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	5108920
51058226	51058248	18	-	27760321	HT29	viability after 19 days	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	-0.9113342024336579	[47,37]	[78,4,0]	-6	hSpCas9	negative selection	5108921
51047260	51047282	18	+	27760321	HT29	viability after 16 days	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	-0.7469278493239688	[34,27]	[16,9,35]	-6	hSpCas9	negative selection	5192380
51048834	51048856	18	+	27760321	HT29	viability after 16 days	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	-0.17006897472165572	[186,145]	[97,291,96]	-2	hSpCas9	negative selection	5192381
51054872	51054894	18	-	27760321	HT29	viability after 16 days	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	-0.4637591925449157	[819,639]	[533,707,525]	-5	hSpCas9	negative selection	5192382
51054931	51054953	18	-	27760321	HT29	viability after 16 days	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	-0.1840686979425925	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	5192383
51058226	51058248	18	-	27760321	HT29	viability after 16 days	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	-0.6575337164032908	[47,37]	[64,23,5]	-6	hSpCas9	negative selection	5192384
51047260	51047282	18	+	27760321	HT29	viability after 13 days	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	-0.03973932593193563	[34,27]	[74,17,14]	0	hSpCas9	negative selection	5275843
51048834	51048856	18	+	27760321	HT29	viability after 13 days	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	0.15619342889484789	[186,145]	[281,155,207]	2	hSpCas9	negative selection	5275844
51054872	51054894	18	-	27760321	HT29	viability after 13 days	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	-0.03695644729799075	[819,639]	[1003,785,693]	0	hSpCas9	negative selection	5275845
51054931	51054953	18	-	27760321	HT29	viability after 13 days	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	-0.23635609738673047	[0,0]	[0,0,0]	-3	hSpCas9	negative selection	5275846
51058226	51058248	18	-	27760321	HT29	viability after 13 days	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	-0.4530440320613063	[47,37]	[12,34,59]	-5	hSpCas9	negative selection	5275847
51047260	51047282	18	+	27760321	HT29	viability after 10 days	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	0.15622723636029257	[34,27]	[10,24,93]	2	hSpCas9	negative selection	5359306
51048834	51048856	18	+	27760321	HT29	viability after 10 days	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	0.058862743197487966	[186,145]	[149,133,359]	0	hSpCas9	negative selection	5359307
51054872	51054894	18	-	27760321	HT29	viability after 10 days	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	-0.43198392939365826	[819,639]	[461,656,901]	-5	hSpCas9	negative selection	5359308
51054931	51054953	18	-	27760321	HT29	viability after 10 days	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	-0.34236740454707437	[0,0]	[0,0,0]	-4	hSpCas9	negative selection	5359309
51058226	51058248	18	-	27760321	HT29	viability after 10 days	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	0.2293308251480588	[47,37]	[99,26,60]	3	hSpCas9	negative selection	5359310
51047260	51047282	18	+	27760321	MOLM13	viability	GTTACCATACAGAGAACATTGG	SMAD4	ENSG00000141646	0.1190028443534552	[33,34]	[44,0]	0	hSpCas9	negative selection	5442769
51048834	51048856	18	+	27760321	MOLM13	viability	ACGAACGAGTTGTATCACCTGG	SMAD4	ENSG00000141646	0.392606496374169	[228,186]	[135,167]	2	hSpCas9	negative selection	5442770
51054872	51054894	18	-	27760321	MOLM13	viability	ACGATTACTTGGTGGATGCTGG	SMAD4	ENSG00000141646	1.2050882916754007	[890,819]	[363,1749]	8	hSpCas9	negative selection	5442771
51054931	51054953	18	-	27760321	MOLM13	viability	GTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.8210053139495912	[0,0]	[0,0]	6	hSpCas9	negative selection	5442772
51058226	51058248	18	-	27760321	MOLM13	viability	TACTATGATGGTAAGTAGCTGG	SMAD4	ENSG00000141646	-1.2826106944134885	[58,47]	[0,21]	-6	hSpCas9	negative selection	5442773
51030315	51030338	18	-	27661255	K562	viability	GCCTCCCGAGGAGAGCGGGAAGG	SMAD4	ENSG00000141646	-1.053449489241986	[338,391]	[169,114]	-8	dCas9-KRAB	negative selection	5512786
51067091	51067114	18	-	27260156	BXPC3	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.15012734046624587	[307]	[210,233,326,414]	-3	hSpCas9	negative selection	5571667
51067008	51067031	18	+	27260156	BXPC3	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.43756809773416205	[1109]	[1341,1580,1553,1858]	8	hSpCas9	negative selection	5571668
51059905	51059928	18	-	27260156	BXPC3	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.06396801248673123	[984]	[967,1124,963,1272]	1	hSpCas9	negative selection	5571669
51049303	51049326	18	+	27260156	BXPC3	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.1949622143132932	[296]	[170,209,366,362]	-4	hSpCas9	negative selection	5635920
51059868	51059891	18	-	27260156	BXPC3	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.009845461658802512	[917]	[909,790,1143,982]	0	hSpCas9	negative selection	5635921
51067076	51067099	18	+	27260156	BXPC3	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.11899296894579682	[508]	[460,491,428,588]	-3	hSpCas9	negative selection	5635922
51067091	51067114	18	-	27260156	A673	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.2912935868303397	[307]	[410,281,255,270]	-6	hSpCas9	negative selection	5692918
51067008	51067031	18	+	27260156	A673	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	-0.058294312605991605	[1109]	[1245,1397,1221,1242]	-1	hSpCas9	negative selection	5692919
51059905	51059928	18	-	27260156	A673	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.087103045675614	[984]	[1218,1011,1022,1218]	-2	hSpCas9	negative selection	5692920
51049303	51049326	18	+	27260156	A673	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.16291586241070632	[296]	[332,327,282,331]	-4	hSpCas9	negative selection	5757171
51059868	51059891	18	-	27260156	A673	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.1638454918039436	[917]	[1066,974,949,949]	-4	hSpCas9	negative selection	5757172
51067076	51067099	18	+	27260156	A673	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.36354413803697266	[508]	[590,353,488,481]	-7	hSpCas9	negative selection	5757173
51067091	51067114	18	-	27260156	A375	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.37582424834774075	[307]	[193,464,165,304]	-5	hSpCas9	negative selection	5814169
51067008	51067031	18	+	27260156	A375	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.20116211984586774	[1109]	[1446,1755,1339,1453]	3	hSpCas9	negative selection	5814170
51059905	51059928	18	-	27260156	A375	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.25890195396728033	[984]	[1494,1694,1337,1056]	4	hSpCas9	negative selection	5814171
51049303	51049326	18	+	27260156	A375	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.34423224878523784	[296]	[256,300,257,278]	-5	hSpCas9	negative selection	5878422
51059868	51059891	18	-	27260156	A375	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.05677385958330727	[917]	[877,1636,799,902]	-1	hSpCas9	negative selection	5878423
51067076	51067099	18	+	27260156	A375	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.16541271725350618	[508]	[817,507,303,491]	-2	hSpCas9	negative selection	5878424
51067091	51067114	18	-	27260156	COLO741	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.093041012185055	[307]	[337,527,387]	2	hSpCas9	negative selection	5935420
51067008	51067031	18	+	27260156	COLO741	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.18769097553317637	[1109]	[1809,1761,1309]	4	hSpCas9	negative selection	5935421
51059905	51059928	18	-	27260156	COLO741	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.05995119779659697	[984]	[1346,1070,1502]	1	hSpCas9	negative selection	5935422
51049303	51049326	18	+	27260156	COLO741	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.013857780821291299	[296]	[381,334,427]	0	hSpCas9	negative selection	5999673
51059868	51059891	18	-	27260156	COLO741	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.19083026729501518	[917]	[1046,963,1067]	-4	hSpCas9	negative selection	5999674
51067076	51067099	18	+	27260156	COLO741	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.016306920556445878	[508]	[660,775,502]	0	hSpCas9	negative selection	5999675
51067091	51067114	18	-	27260156	CAL120	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.9474737742430357	[307]	[199,234,161]	-8	hSpCas9	negative selection	6056671
51067008	51067031	18	+	27260156	CAL120	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	-0.7953764933166757	[1109]	[1022,631,766]	-8	hSpCas9	negative selection	6056672
51059905	51059928	18	-	27260156	CAL120	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.05543011371528439	[984]	[1175,983,1373]	-1	hSpCas9	negative selection	6056673
51049303	51049326	18	+	27260156	CAL120	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.11059993727883122	[296]	[352,437,398]	1	hSpCas9	negative selection	6120924
51059868	51059891	18	-	27260156	CAL120	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.15052750517771962	[917]	[744,1084,1210]	-2	hSpCas9	negative selection	6120925
51067076	51067099	18	+	27260156	CAL120	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.7571007384559841	[508]	[237,346,515]	-8	hSpCas9	negative selection	6120926
51067091	51067114	18	-	27260156	CADOES1	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.3655946363133178	[307]	[189,227,157,316]	-6	hSpCas9	negative selection	6177922
51067008	51067031	18	+	27260156	CADOES1	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.1970553022634811	[1109]	[1212,1128,1096,1298]	3	hSpCas9	negative selection	6177923
51059905	51059928	18	-	27260156	CADOES1	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.04245974009142861	[984]	[818,983,957,1015]	0	hSpCas9	negative selection	6177924
51049303	51049326	18	+	27260156	CADOES1	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.27506640867890053	[296]	[254,260,171,224]	-5	hSpCas9	negative selection	6242175
51059868	51059891	18	-	27260156	CADOES1	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.006394633727571208	[917]	[743,1143,891,611]	0	hSpCas9	negative selection	6242176
51067076	51067099	18	+	27260156	CADOES1	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.4058261664165277	[508]	[371,363,342,349]	-6	hSpCas9	negative selection	6242177
51067091	51067114	18	-	27260156	EWS502	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.2542337698275847	[307]	[295,281,228,282]	-4	hSpCas9	negative selection	6299173
51067008	51067031	18	+	27260156	EWS502	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.06351653456572048	[1109]	[1018,1353,1126,1443]	1	hSpCas9	negative selection	6299174
51059905	51059928	18	-	27260156	EWS502	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.04526427952730905	[984]	[937,1179,930,1277]	0	hSpCas9	negative selection	6299175
51049303	51049326	18	+	27260156	EWS502	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.2795013010290365	[296]	[180,202,317,352]	-5	hSpCas9	negative selection	6363426
51059868	51059891	18	-	27260156	EWS502	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.16877668695397952	[917]	[679,837,1025,943]	-3	hSpCas9	negative selection	6363427
51067076	51067099	18	+	27260156	EWS502	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.25011503211498726	[508]	[328,486,438,578]	-4	hSpCas9	negative selection	6363428
51067091	51067114	18	-	27260156	EW8	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.028731933631865547	[307]	[379,254,222,138]	0	hSpCas9	negative selection	6420424
51067008	51067031	18	+	27260156	EW8	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.21698929046385707	[1109]	[1268,1128,901,928]	4	hSpCas9	negative selection	6420425
51059905	51059928	18	-	27260156	EW8	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.23772166689176144	[984]	[1232,1126,746,721]	4	hSpCas9	negative selection	6420426
51049303	51049326	18	+	27260156	EW8	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.29778140083586946	[296]	[323,162,170,142]	-5	hSpCas9	negative selection	6484677
51059868	51059891	18	-	27260156	EW8	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.026251000678350178	[917]	[751,980,510,716]	0	hSpCas9	negative selection	6484678
51067076	51067099	18	+	27260156	EW8	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.25553443532644166	[508]	[516,451,352,671]	5	hSpCas9	negative selection	6484679
51067091	51067114	18	-	27260156	CORL105	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.4880426829277044	[307]	[621,406,588,423]	8	hSpCas9	negative selection	6541675
51067008	51067031	18	+	27260156	CORL105	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.8982044679633783	[1109]	[2307,2555,2264,2525]	9	hSpCas9	negative selection	6541676
51059905	51059928	18	-	27260156	CORL105	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.40564443091068236	[984]	[1576,1502,1509,1518]	7	hSpCas9	negative selection	6541677
51049303	51049326	18	+	27260156	CORL105	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.06701737803008989	[296]	[292,355,431,383]	1	hSpCas9	negative selection	6605928
51059868	51059891	18	-	27260156	CORL105	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	0.05278905311179927	[917]	[1142,1111,1272,956]	1	hSpCas9	negative selection	6605929
51067076	51067099	18	+	27260156	CORL105	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.4237549138627867	[508]	[816,794,925,679]	7	hSpCas9	negative selection	6605930
51067091	51067114	18	-	27260156	HS294T	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.104696550549081	[307]	[90,56,170,212]	1	hSpCas9	negative selection	6662926
51067008	51067031	18	+	27260156	HS294T	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	-0.491037365626234	[1109]	[191,298,363,390]	-6	hSpCas9	negative selection	6662927
51059905	51059928	18	-	27260156	HS294T	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.2978206869470217	[984]	[365,324,551,677]	4	hSpCas9	negative selection	6662928
51049303	51049326	18	+	27260156	HS294T	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.6718834000973006	[296]	[55,46,77,116]	-7	hSpCas9	negative selection	6727179
51059868	51059891	18	-	27260156	HS294T	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.05952923201132976	[917]	[387,200,378,403]	-1	hSpCas9	negative selection	6727180
51067076	51067099	18	+	27260156	HS294T	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.6240011114146701	[508]	[136,103,137,131]	-7	hSpCas9	negative selection	6727181
51067091	51067114	18	-	27260156	HCC44	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.0732256380447448	[307]	[295,235,588,257]	-1	hSpCas9	negative selection	6784177
51067008	51067031	18	+	27260156	HCC44	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.13174744707871922	[1109]	[1782,1013,1579,1241]	2	hSpCas9	negative selection	6784178
51059905	51059928	18	-	27260156	HCC44	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.4433460970523211	[984]	[1531,1425,1496,1599]	7	hSpCas9	negative selection	6784179
51049303	51049326	18	+	27260156	HCC44	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.12282133675181184	[296]	[279,207,274,468]	-2	hSpCas9	negative selection	6848430
51059868	51059891	18	-	27260156	HCC44	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	0.37496167698277183	[917]	[1816,1204,1327,1092]	6	hSpCas9	negative selection	6848431
51067076	51067099	18	+	27260156	HCC44	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.1212201375846388	[508]	[625,494,437,550]	-2	hSpCas9	negative selection	6848432
51067091	51067114	18	-	27260156	G402	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.009940649101730425	[307]	[578,465,285,203]	0	hSpCas9	negative selection	6905428
51067008	51067031	18	+	27260156	G402	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.15924543151998782	[1109]	[2239,1429,1208,1276]	2	hSpCas9	negative selection	6905429
51059905	51059928	18	-	27260156	G402	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.17756274307119635	[984]	[2193,1040,1087,1217]	2	hSpCas9	negative selection	6905430
51049303	51049326	18	+	27260156	G402	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.0018555995263132008	[296]	[420,188,370,458]	0	hSpCas9	negative selection	6969681
51059868	51059891	18	-	27260156	G402	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	0.12615527251878345	[917]	[1324,1574,1082,950]	1	hSpCas9	negative selection	6969682
51067076	51067099	18	+	27260156	G402	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.15562847420459297	[508]	[376,426,568,808]	-2	hSpCas9	negative selection	6969683
51067091	51067114	18	-	27260156	L33	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.12820590330768877	[307]	[279,102,190,291]	-3	hSpCas9	negative selection	7026679
51067008	51067031	18	+	27260156	L33	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.02317217772960989	[1109]	[965,528,623,1263]	0	hSpCas9	negative selection	7026680
51059905	51059928	18	-	27260156	L33	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.1694881134545072	[984]	[1179,434,717,1045]	4	hSpCas9	negative selection	7026681
51049303	51049326	18	+	27260156	L33	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.6365389298730593	[296]	[165,90,131,166]	-9	hSpCas9	negative selection	7090932
51059868	51059891	18	-	27260156	L33	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.19697040785691555	[917]	[939,320,543,612]	-4	hSpCas9	negative selection	7090933
51067076	51067099	18	+	27260156	L33	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.6610307288720293	[508]	[391,97,240,271]	-9	hSpCas9	negative selection	7090934
51067091	51067114	18	-	27260156	K562	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.9560621367747157	[307]	[41,117,321,78]	-8	hSpCas9	negative selection	7147930
51067008	51067031	18	+	27260156	K562	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	-0.20082808175240752	[1109]	[756,1075,833,770]	-3	hSpCas9	negative selection	7147931
51059905	51059928	18	-	27260156	K562	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.07013996985757154	[984]	[727,1578,1008,427]	0	hSpCas9	negative selection	7147932
51049303	51049326	18	+	27260156	K562	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.47909701449909337	[296]	[213,149,253,142]	-5	hSpCas9	negative selection	7212183
51059868	51059891	18	-	27260156	K562	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	0.06494303715932326	[917]	[1251,718,656,807]	0	hSpCas9	negative selection	7212184
51067076	51067099	18	+	27260156	K562	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.8323519536444437	[508]	[303,301,204,213]	-7	hSpCas9	negative selection	7212185
51067091	51067114	18	-	27260156	HT29	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.3953069669962652	[307]	[351,285,264,243]	-6	hSpCas9	negative selection	7269181
51067008	51067031	18	+	27260156	HT29	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.16919090414300642	[1109]	[1545,1650,1612,1289]	3	hSpCas9	negative selection	7269182
51059905	51059928	18	-	27260156	HT29	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.03669902469202535	[984]	[1268,959,1256,1164]	0	hSpCas9	negative selection	7269183
51049303	51049326	18	+	27260156	HT29	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.06802585200745381	[296]	[307,470,311,297]	-1	hSpCas9	negative selection	7333434
51059868	51059891	18	-	27260156	HT29	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.0830295281925354	[917]	[1085,999,1115,1007]	-2	hSpCas9	negative selection	7333435
51067076	51067099	18	+	27260156	HT29	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.16666441541065474	[508]	[702,704,420,413]	-3	hSpCas9	negative selection	7333436
51067091	51067114	18	-	27260156	MHHES1	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.6686328491349574	[307]	[155,185,243,260]	-8	hSpCas9	negative selection	7390432
51067008	51067031	18	+	27260156	MHHES1	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	-0.37482111342207336	[1109]	[1008,1294,872,746]	-6	hSpCas9	negative selection	7390433
51059905	51059928	18	-	27260156	MHHES1	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.03914360386053417	[984]	[1241,946,1454,932]	0	hSpCas9	negative selection	7390434
51049303	51049326	18	+	27260156	MHHES1	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.09104073976370952	[296]	[261,340,371,278]	-2	hSpCas9	negative selection	7454685
51059868	51059891	18	-	27260156	MHHES1	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.2793610994052471	[917]	[864,1134,1094,425]	-5	hSpCas9	negative selection	7454686
51067076	51067099	18	+	27260156	MHHES1	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.475699227129345	[508]	[341,414,292,547]	-7	hSpCas9	negative selection	7454687
51067091	51067114	18	-	27260156	MEWO	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.15475436030862233	[307]	[290,197,293]	-3	hSpCas9	negative selection	7511683
51067008	51067031	18	+	27260156	MEWO	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	-0.010598946270002685	[1109]	[1285,992,862]	0	hSpCas9	negative selection	7511684
51059905	51059928	18	-	27260156	MEWO	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.24138922743535796	[984]	[784,682,871]	-5	hSpCas9	negative selection	7511685
51049303	51049326	18	+	27260156	MEWO	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.32172208596794716	[296]	[161,268,223]	-6	hSpCas9	negative selection	7575936
51059868	51059891	18	-	27260156	MEWO	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.08101615313046728	[917]	[975,696,794]	-2	hSpCas9	negative selection	7575937
51067076	51067099	18	+	27260156	MEWO	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.14229883344664956	[508]	[360,363,555]	-3	hSpCas9	negative selection	7575938
51067091	51067114	18	-	27260156	LNCAPCLONEFGC	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.9807436885730314	[307]	[137,127,111,183]	-8	hSpCas9	negative selection	7632934
51067008	51067031	18	+	27260156	LNCAPCLONEFGC	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	-1.077046298388196	[1109]	[498,468,488,450]	-9	hSpCas9	negative selection	7632935
51059905	51059928	18	-	27260156	LNCAPCLONEFGC	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.28143106272035945	[984]	[752,726,685,762]	-4	hSpCas9	negative selection	7632936
51049303	51049326	18	+	27260156	LNCAPCLONEFGC	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.1582000355334804	[296]	[258,258,195,241]	-3	hSpCas9	negative selection	7697187
51059868	51059891	18	-	27260156	LNCAPCLONEFGC	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.1630101909590409	[917]	[846,632,852,658]	-3	hSpCas9	negative selection	7697188
51067076	51067099	18	+	27260156	LNCAPCLONEFGC	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.8136525114645081	[508]	[238,143,299,379]	-8	hSpCas9	negative selection	7697189
51067091	51067114	18	-	27260156	PANC0327	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.236389409707762	[307]	[198,301,135,279]	-4	hSpCas9	negative selection	7754185
51067008	51067031	18	+	27260156	PANC0327	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.3175284226550974	[1109]	[1640,1141,1263,912]	5	hSpCas9	negative selection	7754186
51059905	51059928	18	-	27260156	PANC0327	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.02011710487601226	[984]	[910,684,1000,979]	0	hSpCas9	negative selection	7754187
51049303	51049326	18	+	27260156	PANC0327	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.00193317214851485	[296]	[144,114,286,518]	0	hSpCas9	negative selection	7818438
51059868	51059891	18	-	27260156	PANC0327	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	0.2229902046593618	[917]	[1085,931,770,1030]	3	hSpCas9	negative selection	7818439
51067076	51067099	18	+	27260156	PANC0327	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.1023794074920709	[508]	[660,327,276,449]	-1	hSpCas9	negative selection	7818440
51067091	51067114	18	-	27260156	NCIH2009	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.529114728295612	[307]	[831,487,585]	7	hSpCas9	negative selection	7875436
51067008	51067031	18	+	27260156	NCIH2009	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.23727685083035777	[1109]	[1911,1757,1828]	3	hSpCas9	negative selection	7875437
51059905	51059928	18	-	27260156	NCIH2009	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.5079673640405289	[984]	[1813,2312,1705]	7	hSpCas9	negative selection	7875438
51049303	51049326	18	+	27260156	NCIH2009	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.012768845888970204	[296]	[456,368,416]	0	hSpCas9	negative selection	7939689
51059868	51059891	18	-	27260156	NCIH2009	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.25527484609852147	[917]	[1170,743,1331]	-3	hSpCas9	negative selection	7939690
51067076	51067099	18	+	27260156	NCIH2009	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.04629540609893758	[508]	[918,804,512]	0	hSpCas9	negative selection	7939691
51067091	51067114	18	-	27260156	NCIH1373	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.1671500944458958	[307]	[261,331,280,90]	-2	hSpCas9	negative selection	7996687
51067008	51067031	18	+	27260156	NCIH1373	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.33213831801160554	[1109]	[1918,1353,1365,448]	3	hSpCas9	negative selection	7996688
51059905	51059928	18	-	27260156	NCIH1373	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.5154000602152256	[984]	[1932,1398,1546,392]	5	hSpCas9	negative selection	7996689
51049303	51049326	18	+	27260156	NCIH1373	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.09381978969854687	[296]	[415,345,254,109]	0	hSpCas9	negative selection	8060940
51059868	51059891	18	-	27260156	NCIH1373	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	0.16164831034286042	[917]	[1310,1383,760,301]	1	hSpCas9	negative selection	8060941
51067076	51067099	18	+	27260156	NCIH1373	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.1685046965197517	[508]	[467,296,403,382]	1	hSpCas9	negative selection	8060942
51067091	51067114	18	-	27260156	PATU8902	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.16582143650358738	[307]	[455,358,597,476]	1	hSpCas9	negative selection	8117938
51067008	51067031	18	+	27260156	PATU8902	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.41296340924585806	[1109]	[1995,1920,1850,2562]	4	hSpCas9	negative selection	8117939
51059905	51059928	18	-	27260156	PATU8902	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.2352310985342636	[984]	[1734,1752,1372,1650]	2	hSpCas9	negative selection	8117940
51049303	51049326	18	+	27260156	PATU8902	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.5644887023862124	[296]	[799,236,491,984]	6	hSpCas9	negative selection	8182191
51059868	51059891	18	-	27260156	PATU8902	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	0.002487309050205222	[917]	[1359,1686,659,1605]	0	hSpCas9	negative selection	8182192
51067076	51067099	18	+	27260156	PATU8902	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.20433371444877158	[508]	[945,1373,589,353]	2	hSpCas9	negative selection	8182193
51067091	51067114	18	-	27260156	PANC1	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.9325836477967173	[307]	[89,241,168,82]	-8	hSpCas9	negative selection	8239189
51067008	51067031	18	+	27260156	PANC1	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	-0.7748876383635295	[1109]	[517,815,552,410]	-8	hSpCas9	negative selection	8239190
51059905	51059928	18	-	27260156	PANC1	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.16786438675407667	[984]	[879,981,609,596]	-3	hSpCas9	negative selection	8239191
51049303	51049326	18	+	27260156	PANC1	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.044046864801331576	[296]	[297,224,271,193]	0	hSpCas9	negative selection	8303442
51059868	51059891	18	-	27260156	PANC1	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.19198174515969235	[917]	[544,1118,795,425]	-3	hSpCas9	negative selection	8303443
51067076	51067099	18	+	27260156	PANC1	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.8984701617523193	[508]	[275,371,201,128]	-8	hSpCas9	negative selection	8303444
51067091	51067114	18	-	27260156	PANC0813	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.11420883849619684	[307]	[362,398,320,474]	1	hSpCas9	negative selection	8360440
51067008	51067031	18	+	27260156	PANC0813	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.23163193075043798	[1109]	[1493,1297,1586,1727]	4	hSpCas9	negative selection	8360441
51059905	51059928	18	-	27260156	PANC0813	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.31321613377724544	[984]	[1500,1563,1219,1465]	5	hSpCas9	negative selection	8360442
51049303	51049326	18	+	27260156	PANC0813	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.09853704845231592	[296]	[519,387,270,329]	1	hSpCas9	negative selection	8424693
51059868	51059891	18	-	27260156	PANC0813	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.3235798421214636	[917]	[1087,904,765,714]	-5	hSpCas9	negative selection	8424694
51067076	51067099	18	+	27260156	PANC0813	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.093290493123497	[508]	[539,731,508,752]	1	hSpCas9	negative selection	8424695
51067091	51067114	18	-	27260156	RDES	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.3013168735788184	[307]	[293,188,277,404]	-5	hSpCas9	negative selection	8481691
51067008	51067031	18	+	27260156	RDES	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	-0.012145308220739892	[1109]	[1066,1153,1308,1600]	0	hSpCas9	negative selection	8481692
51059905	51059928	18	-	27260156	RDES	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.016735521628455485	[984]	[998,1098,1160,1229]	0	hSpCas9	negative selection	8481693
51049303	51049326	18	+	27260156	RDES	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.22390948591241122	[296]	[286,255,279,349]	-4	hSpCas9	negative selection	8545944
51059868	51059891	18	-	27260156	RDES	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.280521763603814	[917]	[728,769,844,1194]	-5	hSpCas9	negative selection	8545945
51067076	51067099	18	+	27260156	RDES	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.08680899310511997	[508]	[508,508,603,584]	-1	hSpCas9	negative selection	8545946
51067091	51067114	18	-	27260156	PC3	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.2169487150891818	[307]	[130,179,483,395]	-5	hSpCas9	negative selection	8602942
51067008	51067031	18	+	27260156	PC3	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.1050330934655721	[1109]	[758,1226,1976,1170]	2	hSpCas9	negative selection	8602943
51059905	51059928	18	-	27260156	PC3	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.06887447088065068	[984]	[604,890,1332,1131]	-1	hSpCas9	negative selection	8602944
51049303	51049326	18	+	27260156	PC3	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.2791101928868027	[296]	[171,189,487,228]	-6	hSpCas9	negative selection	8667195
51059868	51059891	18	-	27260156	PC3	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.12289482772688021	[917]	[497,835,1341,957]	-3	hSpCas9	negative selection	8667196
51067076	51067099	18	+	27260156	PC3	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.012332190451915151	[508]	[343,526,862,466]	0	hSpCas9	negative selection	8667197
51067091	51067114	18	-	27260156	PATU8988T	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.14962700931152195	[307]	[105,287,400,278]	-3	hSpCas9	negative selection	8724193
51067008	51067031	18	+	27260156	PATU8988T	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.5448081786396797	[1109]	[1508,1325,1759,1644]	8	hSpCas9	negative selection	8724194
51059905	51059928	18	-	27260156	PATU8988T	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.2179830994458225	[984]	[456,1061,917,860]	-4	hSpCas9	negative selection	8724195
51049303	51049326	18	+	27260156	PATU8988T	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	0.3853786912159684	[296]	[252,396,387,470]	6	hSpCas9	negative selection	8788446
51059868	51059891	18	-	27260156	PATU8988T	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	0.3453044745998043	[917]	[988,1132,1191,1198]	6	hSpCas9	negative selection	8788447
51067076	51067099	18	+	27260156	PATU8988T	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.0479290283192597	[508]	[262,326,889,396]	-1	hSpCas9	negative selection	8788448
51067091	51067114	18	-	27260156	T47D	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.7454358369767118	[307]	[183,235,217,215]	-9	hSpCas9	negative selection	8845444
51067008	51067031	18	+	27260156	T47D	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	-0.406634042617128	[1109]	[965,900,998,1043]	-7	hSpCas9	negative selection	8845445
51059905	51059928	18	-	27260156	T47D	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.1580256140542189	[984]	[1300,1119,1443,1266]	3	hSpCas9	negative selection	8845446
51049303	51049326	18	+	27260156	T47D	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.3622362921800877	[296]	[275,256,185,362]	-6	hSpCas9	negative selection	8909697
51059868	51059891	18	-	27260156	T47D	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.10916694364280444	[917]	[973,951,911,1136]	-2	hSpCas9	negative selection	8909698
51067076	51067099	18	+	27260156	T47D	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.8259860822543004	[508]	[338,322,296,381]	-9	hSpCas9	negative selection	8909699
51067091	51067114	18	-	27260156	SU8686	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.06472554344747128	[307]	[266,261,353,290]	-1	hSpCas9	negative selection	8966695
51067008	51067031	18	+	27260156	SU8686	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.2872588596931862	[1109]	[1188,1195,1585,1451]	5	hSpCas9	negative selection	8966696
51059905	51059928	18	-	27260156	SU8686	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.2102851940062811	[984]	[1175,877,1041,1499]	3	hSpCas9	negative selection	8966697
51049303	51049326	18	+	27260156	SU8686	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.09578439258651006	[296]	[197,293,280,344]	-2	hSpCas9	negative selection	9030948
51059868	51059891	18	-	27260156	SU8686	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.0999684322030654	[917]	[914,657,1043,785]	-2	hSpCas9	negative selection	9030949
51067076	51067099	18	+	27260156	SU8686	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.10268736651329344	[508]	[377,361,605,575]	-2	hSpCas9	negative selection	9030950
51067091	51067114	18	-	27260156	SKES1	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.13575747230153723	[307]	[328,240,299,250]	-3	hSpCas9	negative selection	9087946
51067008	51067031	18	+	27260156	SKES1	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	-0.10025022984054677	[1109]	[962,1135,950,1069]	-2	hSpCas9	negative selection	9087947
51059905	51059928	18	-	27260156	SKES1	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.07852776565161013	[984]	[1007,1212,1107,848]	1	hSpCas9	negative selection	9087948
51049303	51049326	18	+	27260156	SKES1	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.14273547675816345	[296]	[287,360,232,209]	-3	hSpCas9	negative selection	9152199
51059868	51059891	18	-	27260156	SKES1	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.20539388877695097	[917]	[941,905,755,619]	-4	hSpCas9	negative selection	9152200
51067076	51067099	18	+	27260156	SKES1	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.2177150374742161	[508]	[599,472,331,372]	-5	hSpCas9	negative selection	9152201
51067091	51067114	18	-	27260156	TOV112D	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.29447471669024217	[307]	[177,537,247,109]	-5	hSpCas9	negative selection	9209197
51067008	51067031	18	+	27260156	TOV112D	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.4259762284723625	[1109]	[1142,2599,1028,1443]	7	hSpCas9	negative selection	9209198
51059905	51059928	18	-	27260156	TOV112D	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	0.10185809128167334	[984]	[1365,1061,891,942]	2	hSpCas9	negative selection	9209199
51049303	51049326	18	+	27260156	TOV112D	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.002890118772344241	[296]	[345,406,196,268]	0	hSpCas9	negative selection	9273450
51059868	51059891	18	-	27260156	TOV112D	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	0.0020997866043012126	[917]	[903,1329,559,984]	0	hSpCas9	negative selection	9273451
51067076	51067099	18	+	27260156	TOV112D	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.22073727151209865	[508]	[484,527,454,310]	-4	hSpCas9	negative selection	9273452
51067091	51067114	18	-	27260156	TC71	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.3202043787170925	[307]	[345,265,247,191]	-7	hSpCas9	negative selection	9330448
51067008	51067031	18	+	27260156	TC71	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	0.12214746510109009	[1109]	[1370,1238,1251,1318]	3	hSpCas9	negative selection	9330449
51059905	51059928	18	-	27260156	TC71	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.15172424699813503	[984]	[805,920,1015,1066]	-4	hSpCas9	negative selection	9330450
51049303	51049326	18	+	27260156	TC71	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.12439737078995938	[296]	[255,350,287,272]	-3	hSpCas9	negative selection	9394701
51059868	51059891	18	-	27260156	TC71	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.06616442483425511	[917]	[855,814,982,1116]	-2	hSpCas9	negative selection	9394702
51067076	51067099	18	+	27260156	TC71	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.4816067073453878	[508]	[399,359,342,465]	-8	hSpCas9	negative selection	9394703
51067091	51067114	18	-	27260156	TC32	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.5247233079423899	[307]	[209,84,254,301]	-7	hSpCas9	negative selection	9451699
51067008	51067031	18	+	27260156	TC32	viability	TTCTTCCTAAGGTTGCACATAGG	SMAD4	ENSG00000141646	-0.6138640177986231	[1109]	[661,484,761,878]	-8	hSpCas9	negative selection	9451700
51059905	51059928	18	-	27260156	TC32	viability	AATACACTTACCAGGATGATTGG	SMAD4	ENSG00000141646	-0.35975369445942107	[984]	[666,385,984,1003]	-6	hSpCas9	negative selection	9451701
51049303	51049326	18	+	27260156	TC32	viability	GGATTAACACTGCAGAGTAATGG	SMAD4	ENSG00000141646	-0.1184001453038831	[296]	[259,188,370,236]	-2	hSpCas9	negative selection	9515952
51059868	51059891	18	-	27260156	TC32	viability	AATGCAAGCTCATTGTGAACAGG	SMAD4	ENSG00000141646	-0.22603642010282088	[917]	[704,546,1172,626]	-4	hSpCas9	negative selection	9515953
51067076	51067099	18	+	27260156	TC32	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.4957738179548066	[508]	[289,278,455,361]	-7	hSpCas9	negative selection	9515954
51047090	51047113	18	-	27869803	HPAFII	viability after 27 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.5889058536513813	[244]	[53,111,NaN]	-4	hSpCas9	negative selection	9564718
51048717	51048740	18	+	27869803	HPAFII	viability after 27 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-3.4467345506236433	[180]	[17,0,NaN]	-9	hSpCas9	negative selection	9564719
51054933	51054956	18	-	27869803	HPAFII	viability after 27 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.5409051781737204	[260]	[179,215,NaN]	4	hSpCas9	negative selection	9564720
51058339	51058362	18	+	27869803	HPAFII	viability after 27 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	1.5149890899413787	[124]	[39,310,NaN]	9	hSpCas9	negative selection	9564721
51067091	51067114	18	-	27869803	HPAFII	viability after 27 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-4.047104693171345	[302]	[1,15,NaN]	-9	hSpCas9	negative selection	9564722
51076658	51076681	18	+	27869803	HPAFII	viability after 27 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	-0.14609145750499564	[167]	[129,37,NaN]	-1	hSpCas9	negative selection	9564723
51047090	51047113	18	-	27869803	HPAFII	viability after 15 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.14039612552353933	[244]	[331,180,NaN]	-2	hSpCas9	negative selection	9647167
51048717	51048740	18	+	27869803	HPAFII	viability after 15 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-2.466258717996669	[180]	[49,25,NaN]	-9	hSpCas9	negative selection	9647168
51054933	51054956	18	-	27869803	HPAFII	viability after 15 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.1537506706380647	[260]	[480,206,NaN]	1	hSpCas9	negative selection	9647169
51058339	51058362	18	+	27869803	HPAFII	viability after 15 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.10114265298777214	[124]	[78,153,NaN]	-1	hSpCas9	negative selection	9647170
51067091	51067114	18	-	27869803	HPAFII	viability after 15 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-2.682591051450587	[302]	[112,11,NaN]	-9	hSpCas9	negative selection	9647171
51076658	51076681	18	+	27869803	HPAFII	viability after 15 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	-0.21035039142832113	[167]	[242,101,NaN]	-2	hSpCas9	negative selection	9647172
51047090	51047113	18	-	27869803	ASPC1	viability after 36 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	0.7257779617878123	[808]	[236,250,794]	7	hSpCas9	negative selection	9729616
51048717	51048740	18	+	27869803	ASPC1	viability after 36 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-1.0085938592284158	[431]	[115,53,61]	-7	hSpCas9	negative selection	9729617
51054933	51054956	18	-	27869803	ASPC1	viability after 36 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.3220247894035199	[434]	[136,166,242]	3	hSpCas9	negative selection	9729618
51058339	51058362	18	+	27869803	ASPC1	viability after 36 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	-0.22349644594712803	[399]	[322,69,14]	-2	hSpCas9	negative selection	9729619
51067091	51067114	18	-	27869803	ASPC1	viability after 36 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	1.2428942460234058	[659]	[735,326,578]	9	hSpCas9	negative selection	9729620
51076658	51076681	18	+	27869803	ASPC1	viability after 36 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	-1.6575760201090004	[567]	[140,56,11]	-9	hSpCas9	negative selection	9729621
51047090	51047113	18	-	27869803	PATU8988S	viability after 35 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	0.3611994803433238	[546]	[273,291,NaN]	4	hSpCas9	negative selection	9812065
51048717	51048740	18	+	27869803	PATU8988S	viability after 35 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.954810735552865	[275]	[198,231,NaN]	8	hSpCas9	negative selection	9812066
51054933	51054956	18	-	27869803	PATU8988S	viability after 35 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.12432016176374927	[337]	[95,200,NaN]	1	hSpCas9	negative selection	9812067
51058339	51058362	18	+	27869803	PATU8988S	viability after 35 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	0.08280102459588945	[142]	[58,62,NaN]	1	hSpCas9	negative selection	9812068
51067091	51067114	18	-	27869803	PATU8988S	viability after 35 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.285772953990258	[533]	[341,181,NaN]	3	hSpCas9	negative selection	9812069
51076658	51076681	18	+	27869803	PATU8988S	viability after 35 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	0.048693788051195105	[559]	[137,328,NaN]	0	hSpCas9	negative selection	9812070
51047090	51047113	18	-	27869803	PATU8988S	viability after 31 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	0.4550499602994555	[546]	[276,326,NaN]	5	hSpCas9	negative selection	9894514
51048717	51048740	18	+	27869803	PATU8988S	viability after 31 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	1.142957163486966	[275]	[213,279,NaN]	9	hSpCas9	negative selection	9894515
51054933	51054956	18	-	27869803	PATU8988S	viability after 31 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.41507622441179326	[337]	[107,270,NaN]	5	hSpCas9	negative selection	9894516
51058339	51058362	18	+	27869803	PATU8988S	viability after 31 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	0.5819016874471659	[142]	[32,151,NaN]	7	hSpCas9	negative selection	9894517
51067091	51067114	18	-	27869803	PATU8988S	viability after 31 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.2469534272994767	[533]	[264,236,NaN]	3	hSpCas9	negative selection	9894518
51076658	51076681	18	+	27869803	PATU8988S	viability after 31 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	-0.19997180521010405	[559]	[167,227,NaN]	-2	hSpCas9	negative selection	9894519
51047090	51047113	18	-	27869803	HPAFII	viability after 35 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-0.9858939747955862	[244]	[16,113,NaN]	-5	hSpCas9	negative selection	9976963
51048717	51048740	18	+	27869803	HPAFII	viability after 35 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-4.454991247398158	[180]	[6,0,NaN]	-9	hSpCas9	negative selection	9976964
51054933	51054956	18	-	27869803	HPAFII	viability after 35 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.24053485437565625	[260]	[125,189,NaN]	1	hSpCas9	negative selection	9976965
51058339	51058362	18	+	27869803	HPAFII	viability after 35 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	1.3423961935796083	[124]	[24,312,NaN]	8	hSpCas9	negative selection	9976966
51067091	51067114	18	-	27869803	HPAFII	viability after 35 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-3.817814250468488	[302]	[0,21,NaN]	-9	hSpCas9	negative selection	9976967
51076658	51076681	18	+	27869803	HPAFII	viability after 35 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	0.4861214847568121	[167]	[136,98,NaN]	3	hSpCas9	negative selection	9976968
51047090	51047113	18	-	27869803	HPAFII	viability after 31 days	ACTATGCACAATGCTCAGACAGG	SMAD4	ENSG00000141646	-1.1108543657157086	[244]	[44,83,NaN]	-6	hSpCas9	negative selection	10059412
51048717	51048740	18	+	27869803	HPAFII	viability after 31 days	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-6.6664746874079475	[180]	[0,0,NaN]	-9	hSpCas9	negative selection	10059413
51054933	51054956	18	-	27869803	HPAFII	viability after 31 days	CTGGTAGCATTAGACTCAGATGG	SMAD4	ENSG00000141646	0.612728113616603	[260]	[111,345,NaN]	4	hSpCas9	negative selection	10059414
51058339	51058362	18	+	27869803	HPAFII	viability after 31 days	GACAGCACTACCACCTGGACTGG	SMAD4	ENSG00000141646	1.0582582087551475	[124]	[13,289,NaN]	7	hSpCas9	negative selection	10059415
51067091	51067114	18	-	27869803	HPAFII	viability after 31 days	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-6.441053717782133	[302]	[0,2,NaN]	-9	hSpCas9	negative selection	10059416
51076658	51076681	18	+	27869803	HPAFII	viability after 31 days	TCATCGACAGATGCAGCAGCAGG	SMAD4	ENSG00000141646	0.4367805551640489	[167]	[174,75,NaN]	3	hSpCas9	negative selection	10059417
51048724	51048747	18	-	28162770	P31FUJ	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	0.06466569848328907	[344]	[423]	0	hSpCas9	negative selection	10238730
51048717	51048740	18	+	28162770	P31FUJ	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.04591382365168484	[304]	[369]	0	hSpCas9	negative selection	10238731
51054916	51054939	18	-	28162770	P31FUJ	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	-0.12224382926667987	[112]	[121]	-1	hSpCas9	negative selection	10238732
51058422	51058445	18	-	28162770	P31FUJ	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	0.6151947021405713	[14]	[26]	7	hSpCas9	negative selection	10238733
51058435	51058458	18	-	28162770	P31FUJ	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	0.22091576302852495	[137]	[188]	2	hSpCas9	negative selection	10238734
51054931	51054954	18	-	28162770	P31FUJ	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.729044972626441	[363]	[708]	8	hSpCas9	negative selection	10238735
51065521	51065544	18	+	28162770	P31FUJ	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	0.17473012520759523	[529]	[702]	1	hSpCas9	negative selection	10238736
51067076	51067099	18	+	28162770	P31FUJ	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.45680473106473674	[544]	[878]	5	hSpCas9	negative selection	10238737
51067091	51067114	18	-	28162770	P31FUJ	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.1627924831666362	[361]	[379]	-1	hSpCas9	negative selection	10238738
51076725	51076748	18	+	28162770	P31FUJ	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.5448053742491734	[426]	[731]	6	hSpCas9	negative selection	10238739
51048724	51048747	18	-	28162770	TF1	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	NaN	[NaN]	[134]	1	hSpCas9	negative selection	10408096
51048717	51048740	18	+	28162770	TF1	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	NaN	[NaN]	[138]	1	hSpCas9	negative selection	10408097
51054916	51054939	18	-	28162770	TF1	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	NaN	[NaN]	[74]	1	hSpCas9	negative selection	10408098
51058422	51058445	18	-	28162770	TF1	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	NaN	[NaN]	[38]	1	hSpCas9	negative selection	10408099
51058435	51058458	18	-	28162770	TF1	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	NaN	[NaN]	[186]	1	hSpCas9	negative selection	10408100
51054931	51054954	18	-	28162770	TF1	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	NaN	[NaN]	[285]	1	hSpCas9	negative selection	10408101
51065521	51065544	18	+	28162770	TF1	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	NaN	[NaN]	[286]	1	hSpCas9	negative selection	10408102
51067076	51067099	18	+	28162770	TF1	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	NaN	[NaN]	[336]	1	hSpCas9	negative selection	10408103
51067091	51067114	18	-	28162770	TF1	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	NaN	[NaN]	[240]	1	hSpCas9	negative selection	10408104
51076725	51076748	18	+	28162770	TF1	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	NaN	[NaN]	[336]	1	hSpCas9	negative selection	10408105
51048724	51048747	18	-	28162770	SKM1	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	-0.20955846087874241	[103]	[158]	-2	hSpCas9	negative selection	10577462
51048717	51048740	18	+	28162770	SKM1	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.975954526033349	[43]	[152]	8	hSpCas9	negative selection	10577463
51054916	51054939	18	-	28162770	SKM1	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.38444917944542084	[38]	[89]	4	hSpCas9	negative selection	10577464
51058422	51058445	18	-	28162770	SKM1	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	-1.3074285251922477	[6]	[4]	-7	hSpCas9	negative selection	10577465
51058435	51058458	18	-	28162770	SKM1	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	0.3520277017530433	[38]	[87]	3	hSpCas9	negative selection	10577466
51054931	51054954	18	-	28162770	SKM1	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.49737069196160033	[112]	[281]	5	hSpCas9	negative selection	10577467
51065521	51065544	18	+	28162770	SKM1	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	-0.2494229217566819	[116]	[173]	-2	hSpCas9	negative selection	10577468
51067076	51067099	18	+	28162770	SKM1	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.09005060270229182	[92]	[174]	0	hSpCas9	negative selection	10577469
51067091	51067114	18	-	28162770	SKM1	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.47989572119701285	[70]	[89]	-4	hSpCas9	negative selection	10577470
51076725	51076748	18	+	28162770	SKM1	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.017533629784748483	[94]	[169]	0	hSpCas9	negative selection	10577471
51048724	51048747	18	-	28162770	SKM1	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	-0.20955846087874241	[103]	[158]	-2	hSpCas9	negative selection	10746828
51048717	51048740	18	+	28162770	SKM1	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.975954526033349	[43]	[152]	8	hSpCas9	negative selection	10746829
51054916	51054939	18	-	28162770	SKM1	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.38444917944542084	[38]	[89]	4	hSpCas9	negative selection	10746830
51058422	51058445	18	-	28162770	SKM1	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	-1.3074285251922477	[6]	[4]	-7	hSpCas9	negative selection	10746831
51058435	51058458	18	-	28162770	SKM1	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	0.3520277017530433	[38]	[87]	3	hSpCas9	negative selection	10746832
51054931	51054954	18	-	28162770	SKM1	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.49737069196160033	[112]	[281]	5	hSpCas9	negative selection	10746833
51065521	51065544	18	+	28162770	SKM1	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	-0.2494229217566819	[116]	[173]	-2	hSpCas9	negative selection	10746834
51067076	51067099	18	+	28162770	SKM1	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.09005060270229182	[92]	[174]	0	hSpCas9	negative selection	10746835
51067091	51067114	18	-	28162770	SKM1	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.47989572119701285	[70]	[89]	-4	hSpCas9	negative selection	10746836
51076725	51076748	18	+	28162770	SKM1	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.017533629784748483	[94]	[169]	0	hSpCas9	negative selection	10746837
51048724	51048747	18	-	28162770	PL21	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	0.6754122209015341	[386]	[268]	6	hSpCas9	negative selection	10916194
51048717	51048740	18	+	28162770	PL21	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.4496592138486325	[142]	[84]	4	hSpCas9	negative selection	10916195
51054916	51054939	18	-	28162770	PL21	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.07912421352795411	[173]	[79]	0	hSpCas9	negative selection	10916196
51058422	51058445	18	-	28162770	PL21	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	-3.6578413806382524	[28]	[0]	-9	hSpCas9	negative selection	10916197
51058435	51058458	18	-	28162770	PL21	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	-0.481684425484425	[153]	[47]	-3	hSpCas9	negative selection	10916198
51054931	51054954	18	-	28162770	PL21	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	-0.11370613410018371	[444]	[178]	-1	hSpCas9	negative selection	10916199
51065521	51065544	18	+	28162770	PL21	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	-0.6417311892687882	[422]	[117]	-4	hSpCas9	negative selection	10916200
51067076	51067099	18	+	28162770	PL21	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.41441470840325845	[330]	[191]	3	hSpCas9	negative selection	10916201
51067091	51067114	18	-	28162770	PL21	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.8606531482176532	[185]	[146]	7	hSpCas9	negative selection	10916202
51076725	51076748	18	+	28162770	PL21	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.5211796237586793	[324]	[202]	4	hSpCas9	negative selection	10916203
51048724	51048747	18	-	28162770	P31FUJ	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	0.06466569848328907	[344]	[423]	0	hSpCas9	negative selection	11085560
51048717	51048740	18	+	28162770	P31FUJ	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.04591382365168484	[304]	[369]	0	hSpCas9	negative selection	11085561
51054916	51054939	18	-	28162770	P31FUJ	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	-0.12224382926667987	[112]	[121]	-1	hSpCas9	negative selection	11085562
51058422	51058445	18	-	28162770	P31FUJ	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	0.6151947021405713	[14]	[26]	7	hSpCas9	negative selection	11085563
51058435	51058458	18	-	28162770	P31FUJ	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	0.22091576302852495	[137]	[188]	2	hSpCas9	negative selection	11085564
51054931	51054954	18	-	28162770	P31FUJ	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.729044972626441	[363]	[708]	8	hSpCas9	negative selection	11085565
51065521	51065544	18	+	28162770	P31FUJ	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	0.17473012520759523	[529]	[702]	1	hSpCas9	negative selection	11085566
51067076	51067099	18	+	28162770	P31FUJ	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.45680473106473674	[544]	[878]	5	hSpCas9	negative selection	11085567
51067091	51067114	18	-	28162770	P31FUJ	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.1627924831666362	[361]	[379]	-1	hSpCas9	negative selection	11085568
51076725	51076748	18	+	28162770	P31FUJ	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.5448053742491734	[426]	[731]	6	hSpCas9	negative selection	11085569
51048724	51048747	18	-	28162770	OCIAML5	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	-1.4510223436646528	[258]	[170]	-7	hSpCas9	negative selection	11254926
51048717	51048740	18	+	28162770	OCIAML5	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	-0.7543698969768637	[156]	[167]	-5	hSpCas9	negative selection	11254927
51054916	51054939	18	-	28162770	OCIAML5	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	1.6584177138978826	[52]	[301]	9	hSpCas9	negative selection	11254928
51058422	51058445	18	-	28162770	OCIAML5	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	-3.437029071585153	[29]	[4]	-9	hSpCas9	negative selection	11254929
51058435	51058458	18	-	28162770	OCIAML5	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	-0.6665109177079205	[152]	[173]	-4	hSpCas9	negative selection	11254930
51054931	51054954	18	-	28162770	OCIAML5	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	-0.043978385745683246	[280]	[491]	0	hSpCas9	negative selection	11254931
51065521	51065544	18	+	28162770	OCIAML5	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	-0.7553905514523231	[302]	[323]	-5	hSpCas9	negative selection	11254932
51067076	51067099	18	+	28162770	OCIAML5	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.021991572306309326	[296]	[527]	0	hSpCas9	negative selection	11254933
51067091	51067114	18	-	28162770	OCIAML5	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.12190615460290516	[169]	[281]	-1	hSpCas9	negative selection	11254934
51076725	51076748	18	+	28162770	OCIAML5	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.026747082615945716	[210]	[387]	0	hSpCas9	negative selection	11254935
51048724	51048747	18	-	28162770	EOL1	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	0.8085639009264665	[711]	[656]	7	hSpCas9	negative selection	11424292
51048717	51048740	18	+	28162770	EOL1	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	1.298799656002878	[286]	[371]	9	hSpCas9	negative selection	11424293
51054916	51054939	18	-	28162770	EOL1	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.5688313632268887	[269]	[210]	5	hSpCas9	negative selection	11424294
51058422	51058445	18	-	28162770	EOL1	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	0.8582052767418384	[88]	[84]	7	hSpCas9	negative selection	11424295
51058435	51058458	18	-	28162770	EOL1	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	1.225645944035458	[292]	[360]	8	hSpCas9	negative selection	11424296
51054931	51054954	18	-	28162770	EOL1	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	-0.0477958855266003	[774]	[394]	0	hSpCas9	negative selection	11424297
51065521	51065544	18	+	28162770	EOL1	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	0.8296361245450679	[533]	[499]	7	hSpCas9	negative selection	11424298
51067076	51067099	18	+	28162770	EOL1	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.9109244877065595	[531]	[526]	7	hSpCas9	negative selection	11424299
51067091	51067114	18	-	28162770	EOL1	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.5113238426636219	[264]	[198]	4	hSpCas9	negative selection	11424300
51076725	51076748	18	+	28162770	EOL1	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	1.0248748302432618	[485]	[520]	8	hSpCas9	negative selection	11424301
51048724	51048747	18	-	28162770	MOLM13	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	0.41761617506335535	[583]	[563]	3	hSpCas9	negative selection	11593658
51048717	51048740	18	+	28162770	MOLM13	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.9872635406381584	[329]	[472]	7	hSpCas9	negative selection	11593659
51054916	51054939	18	-	28162770	MOLM13	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.821121596349951	[154]	[197]	6	hSpCas9	negative selection	11593660
51058422	51058445	18	-	28162770	MOLM13	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	1.5366021316285932	[40]	[85]	9	hSpCas9	negative selection	11593661
51058435	51058458	18	-	28162770	MOLM13	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	0.4739131691723487	[238]	[239]	3	hSpCas9	negative selection	11593662
51054931	51054954	18	-	28162770	MOLM13	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	1.4235366232629731	[544]	[1056]	9	hSpCas9	negative selection	11593663
51065521	51065544	18	+	28162770	MOLM13	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	0.3651107843671427	[508]	[473]	2	hSpCas9	negative selection	11593664
51067076	51067099	18	+	28162770	MOLM13	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.037253038379449155	[500]	[352]	0	hSpCas9	negative selection	11593665
51067091	51067114	18	-	28162770	MOLM13	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.18777611051977916	[344]	[218]	-1	hSpCas9	negative selection	11593666
51076725	51076748	18	+	28162770	MOLM13	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.5298171306877808	[341]	[356]	4	hSpCas9	negative selection	11593667
51048724	51048747	18	-	28162770	HEL	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	0.1228322148675578	[541]	[377]	1	hSpCas9	negative selection	11763024
51048717	51048740	18	+	28162770	HEL	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.0001286722793849837	[216]	[138]	0	hSpCas9	negative selection	11763025
51054916	51054939	18	-	28162770	HEL	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	-0.33126595946669835	[164]	[83]	-2	hSpCas9	negative selection	11763026
51058422	51058445	18	-	28162770	HEL	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	-0.1646160900572471	[27]	[15]	-1	hSpCas9	negative selection	11763027
51058435	51058458	18	-	28162770	HEL	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	-0.02937561781588141	[289]	[181]	0	hSpCas9	negative selection	11763028
51054931	51054954	18	-	28162770	HEL	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.45804711984913227	[490]	[431]	4	hSpCas9	negative selection	11763029
51065521	51065544	18	+	28162770	HEL	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	-0.14633879468513944	[450]	[260]	-1	hSpCas9	negative selection	11763030
51067076	51067099	18	+	28162770	HEL	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.10542496877071328	[387]	[230]	-1	hSpCas9	negative selection	11763031
51067091	51067114	18	-	28162770	HEL	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.5742590941175904	[301]	[287]	5	hSpCas9	negative selection	11763032
51076725	51076748	18	+	28162770	HEL	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.1823502016922195	[376]	[273]	1	hSpCas9	negative selection	11763033
51048724	51048747	18	-	28162770	MV411	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	0.1916742792607662	[421]	[405]	1	hSpCas9	negative selection	11932390
51048717	51048740	18	+	28162770	MV411	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.20204564796876107	[225]	[218]	1	hSpCas9	negative selection	11932391
51054916	51054939	18	-	28162770	MV411	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	-0.21490566327442506	[123]	[89]	-2	hSpCas9	negative selection	11932392
51058422	51058445	18	-	28162770	MV411	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	-0.6701002890252516	[50]	[26]	-5	hSpCas9	negative selection	11932393
51058435	51058458	18	-	28162770	MV411	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	-0.6165008996411963	[181]	[99]	-4	hSpCas9	negative selection	11932394
51054931	51054954	18	-	28162770	MV411	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.25775484176828867	[417]	[420]	2	hSpCas9	negative selection	11932395
51065521	51065544	18	+	28162770	MV411	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	0.16821085963220028	[392]	[371]	1	hSpCas9	negative selection	11932396
51067076	51067099	18	+	28162770	MV411	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.572431948717921	[375]	[470]	5	hSpCas9	negative selection	11932397
51067091	51067114	18	-	28162770	MV411	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.3804990805743651	[206]	[226]	3	hSpCas9	negative selection	11932398
51076725	51076748	18	+	28162770	MV411	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.030019944861619408	[385]	[331]	0	hSpCas9	negative selection	11932399
51048724	51048747	18	-	28162770	MONOMAC1	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	-0.49178011262068577	[275]	[224]	-4	hSpCas9	negative selection	12101756
51048717	51048740	18	+	28162770	MONOMAC1	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.21124328604398138	[106]	[141]	2	hSpCas9	negative selection	12101757
51054916	51054939	18	-	28162770	MONOMAC1	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	-0.4750215943593188	[96]	[79]	-4	hSpCas9	negative selection	12101758
51058422	51058445	18	-	28162770	MONOMAC1	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	1.3879256536616025	[20]	[62]	9	hSpCas9	negative selection	12101759
51058435	51058458	18	-	28162770	MONOMAC1	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	-0.11573674495770574	[137]	[145]	-1	hSpCas9	negative selection	12101760
51054931	51054954	18	-	28162770	MONOMAC1	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.48420930584822786	[226]	[363]	5	hSpCas9	negative selection	12101761
51065521	51065544	18	+	28162770	MONOMAC1	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	-0.05907957427587718	[288]	[317]	0	hSpCas9	negative selection	12101762
51067076	51067099	18	+	28162770	MONOMAC1	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	0.05764100641861314	[201]	[240]	0	hSpCas9	negative selection	12101763
51067091	51067114	18	-	28162770	MONOMAC1	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	0.45981857214338817	[136]	[215]	4	hSpCas9	negative selection	12101764
51076725	51076748	18	+	28162770	MONOMAC1	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.5837449793991422	[226]	[389]	5	hSpCas9	negative selection	12101765
51048724	51048747	18	-	28162770	OCIAML2	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	0.31287835486107496	[60]	[419]	3	hSpCas9	negative selection	12271122
51048717	51048740	18	+	28162770	OCIAML2	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.867849445909049	[25]	[262]	8	hSpCas9	negative selection	12271123
51054916	51054939	18	-	28162770	OCIAML2	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.13817941743336276	[29]	[182]	1	hSpCas9	negative selection	12271124
51058422	51058445	18	-	28162770	OCIAML2	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	0.22980989289893117	[5]	[38]	2	hSpCas9	negative selection	12271125
51058435	51058458	18	-	28162770	OCIAML2	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	-0.03891358481668716	[42]	[231]	0	hSpCas9	negative selection	12271126
51054931	51054954	18	-	28162770	OCIAML2	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.3316895069181447	[81]	[571]	3	hSpCas9	negative selection	12271127
51065521	51065544	18	+	28162770	OCIAML2	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	0.3080138001739152	[57]	[397]	3	hSpCas9	negative selection	12271128
51067076	51067099	18	+	28162770	OCIAML2	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.31451062332487933	[69]	[311]	-3	hSpCas9	negative selection	12271129
51067091	51067114	18	-	28162770	OCIAML2	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.1147543984314611	[41]	[214]	-1	hSpCas9	negative selection	12271130
51076725	51076748	18	+	28162770	OCIAML2	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	-0.2137215222052089	[58]	[281]	-2	hSpCas9	negative selection	12271131
51048724	51048747	18	-	28162770	OCIAML3	viability	GATCAGGCCACCTCCAGAGACGG	SMAD4	ENSG00000141646	0.1966685405868106	[86]	[300]	1	hSpCas9	negative selection	12440488
51048717	51048740	18	+	28162770	OCIAML3	viability	TCTATGCCCGTCTCTGGAGGTGG	SMAD4	ENSG00000141646	0.38174481342915967	[59]	[235]	3	hSpCas9	negative selection	12440489
51054916	51054939	18	-	28162770	OCIAML3	viability	AGATGGGGCTAACAGAGCTGGGG	SMAD4	ENSG00000141646	0.2856981259581249	[49]	[183]	2	hSpCas9	negative selection	12440490
51058422	51058445	18	-	28162770	OCIAML3	viability	GATGGGGCGGCATAGGCGGGTGG	SMAD4	ENSG00000141646	-3.4013625623817676	[6]	[1]	-9	hSpCas9	negative selection	12440491
51058435	51058458	18	-	28162770	OCIAML3	viability	CAGTAATGTCCGGGATGGGGCGG	SMAD4	ENSG00000141646	1.525291288048181	[28]	[251]	9	hSpCas9	negative selection	12440492
51054931	51054954	18	-	28162770	OCIAML3	viability	GGTAGCATTAGACTCAGATGGGG	SMAD4	ENSG00000141646	0.5044822230752004	[137]	[590]	5	hSpCas9	negative selection	12440493
51065521	51065544	18	+	28162770	OCIAML3	viability	GGATACGTGGACCCTTCTGGAGG	SMAD4	ENSG00000141646	-0.8935679221830711	[111]	[181]	-6	hSpCas9	negative selection	12440494
51067076	51067099	18	+	28162770	OCIAML3	viability	CAGGTGCCTTAGTGACCACGCGG	SMAD4	ENSG00000141646	-0.3079565817653974	[113]	[277]	-2	hSpCas9	negative selection	12440495
51067091	51067114	18	-	28162770	OCIAML3	viability	AACTCTGTACAAAGACCGCGTGG	SMAD4	ENSG00000141646	-0.6629549940416544	[74]	[142]	-5	hSpCas9	negative selection	12440496
51076725	51076748	18	+	28162770	OCIAML3	viability	GCAGGAAACATCCCTGGCCCAGG	SMAD4	ENSG00000141646	0.5796404471608664	[85]	[387]	5	hSpCas9	negative selection	12440497