Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 29110
• Symbol: TBK1
• Description: TANK binding kinase 1

DataSource: http://genomecrispr.dkfz.de/#!/results/TBK1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
64481862	64481885	12	-	26472758	Jiyoye	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	0.24542431150926103	[65]	[58]	1	hSpCas9	negative selection	162459
64495561	64495584	12	+	26472758	Jiyoye	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	-0.807837509464977	[129]	[55]	-5	hSpCas9	negative selection	162460
64485459	64485482	12	-	26472758	Jiyoye	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.32209388061610544	[226]	[213]	2	hSpCas9	negative selection	162461
64490053	64490076	12	+	26472758	Jiyoye	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	2.6295678028423213	[23]	[111]	9	hSpCas9	negative selection	162462
64464373	64464396	12	-	26472758	Jiyoye	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.5009575278264902	[401]	[428]	4	hSpCas9	negative selection	162463
64480052	64480075	12	+	26472758	Jiyoye	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	6.914970021704569	[0]	[90]	9	hSpCas9	negative selection	162464
64495547	64495570	12	+	26472758	Jiyoye	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	0.07702677981354243	[131]	[104]	0	hSpCas9	negative selection	162465
64481886	64481909	12	+	26472758	Jiyoye	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.7697454608905818	[104]	[134]	5	hSpCas9	negative selection	162466
64485475	64485498	12	-	26472758	Jiyoye	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	0.10514684405621577	[179]	[145]	0	hSpCas9	negative selection	162467
64495528	64495551	12	+	26472758	Jiyoye	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.744676280313697	[128]	[162]	5	hSpCas9	negative selection	162468
64481862	64481885	12	-	26472758	KBM7	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	0.6822385636858739	[278,214]	[301,79]	7	hSpCas9	negative selection	353577
64495561	64495584	12	+	26472758	KBM7	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	0.3678018381213354	[477,346]	[144,338]	4	hSpCas9	negative selection	353578
64485459	64485482	12	-	26472758	KBM7	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.2920267926089233	[1200,970]	[593,645]	3	hSpCas9	negative selection	353579
64490053	64490076	12	+	26472758	KBM7	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-1.6166890780522492	[411,302]	[49,57]	-8	hSpCas9	negative selection	353580
64464373	64464396	12	-	26472758	KBM7	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.2431898193611759	[1655,981]	[832,615]	2	hSpCas9	negative selection	353581
64480052	64480075	12	+	26472758	KBM7	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	0.1827426673403958	[253,172]	[172,57]	1	hSpCas9	negative selection	353582
64495547	64495570	12	+	26472758	KBM7	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	0.6550122310256602	[383,473]	[358,289]	7	hSpCas9	negative selection	353583
64481886	64481909	12	+	26472758	KBM7	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.6577655677286691	[441,367]	[240,350]	7	hSpCas9	negative selection	353584
64485475	64485498	12	-	26472758	KBM7	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	0.11608212742134949	[664,670]	[290,387]	1	hSpCas9	negative selection	353585
64495528	64495551	12	+	26472758	KBM7	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.4749883125323111	[622,493]	[419,310]	5	hSpCas9	negative selection	353586
64481862	64481885	12	-	26472758	Raji	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	1.4293116302609616	[119]	[74]	9	hSpCas9	negative selection	544695
64495561	64495584	12	+	26472758	Raji	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	0.3418487890106225	[237]	[69]	3	hSpCas9	negative selection	544696
64485459	64485482	12	-	26472758	Raji	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.3621026729953898	[579]	[172]	3	hSpCas9	negative selection	544697
64490053	64490076	12	+	26472758	Raji	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.16309296795988704	[126]	[32]	1	hSpCas9	negative selection	544698
64464373	64464396	12	-	26472758	Raji	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	1.1099079367891462	[570]	[285]	8	hSpCas9	negative selection	544699
64480052	64480075	12	+	26472758	Raji	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	0.9512643334563178	[77]	[34]	8	hSpCas9	negative selection	544700
64495547	64495570	12	+	26472758	Raji	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	0.3957290297365809	[225]	[68]	4	hSpCas9	negative selection	544701
64481886	64481909	12	+	26472758	Raji	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.5033122117047386	[227]	[74]	5	hSpCas9	negative selection	544702
64485475	64485498	12	-	26472758	Raji	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	1.2361168494958021	[299]	[163]	9	hSpCas9	negative selection	544703
64495528	64495551	12	+	26472758	Raji	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.481449253596137	[499]	[161]	4	hSpCas9	negative selection	544704
64481862	64481885	12	-	26472758	K562	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	1.3323452343685964	[182]	[388]	9	hSpCas9	negative selection	735813
64495561	64495584	12	+	26472758	K562	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	0.9386102981423616	[355]	[575]	7	hSpCas9	negative selection	735814
64485459	64485482	12	-	26472758	K562	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.4191263512450494	[869]	[981]	3	hSpCas9	negative selection	735815
64490053	64490076	12	+	26472758	K562	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.37872696694259733	[267]	[173]	-3	hSpCas9	negative selection	735816
64464373	64464396	12	-	26472758	K562	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.37073517744784734	[1070]	[1168]	3	hSpCas9	negative selection	735817
64480052	64480075	12	+	26472758	K562	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	-0.45331170321665926	[265]	[163]	-3	hSpCas9	negative selection	735818
64495547	64495570	12	+	26472758	K562	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	1.1053413137446404	[320]	[582]	8	hSpCas9	negative selection	735819
64481886	64481909	12	+	26472758	K562	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	-0.41240975925403023	[390]	[247]	-3	hSpCas9	negative selection	735820
64485475	64485498	12	-	26472758	K562	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	0.14828163057739718	[635]	[594]	1	hSpCas9	negative selection	735821
64495528	64495551	12	+	26472758	K562	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.0440655545887878	[562]	[489]	0	hSpCas9	negative selection	735822
64460236	64460259	12	-	26627737	DLD1	viability	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.5419166084457254	[589]	[63,209,111]	-5	hSpCas9	negative selection	785107
64474356	64474379	12	-	26627737	DLD1	viability	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.06320180853343108	[483]	[112,185,173]	0	hSpCas9	negative selection	785108
64480070	64480093	12	+	26627737	DLD1	viability	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.1618455925057043	[228]	[39,132,70]	1	hSpCas9	negative selection	785109
64484379	64484402	12	+	26627737	DLD1	viability	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.1459026332079485	[858]	[285,338,271]	1	hSpCas9	negative selection	785110
64485459	64485482	12	-	26627737	DLD1	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	-1.30330131774556	[689]	[138,86,42]	-8	hSpCas9	negative selection	785111
64490053	64490076	12	+	26627737	DLD1	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.005156007791588646	[87]	[19,51,13]	0	hSpCas9	negative selection	785112
64460236	64460259	12	-	26627737	GBM cells	viability after 5 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.6860486258354707	[356]	[115,121]	-8	hSpCas9	negative selection	867422
64474356	64474379	12	-	26627737	GBM cells	viability after 5 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.22214551135109617	[409]	[200,175]	-3	hSpCas9	negative selection	867423
64480070	64480093	12	+	26627737	GBM cells	viability after 5 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.04606756866933981	[148]	[83,80]	0	hSpCas9	negative selection	867424
64484379	64484402	12	+	26627737	GBM cells	viability after 5 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.19862045583217092	[565]	[269,258]	-3	hSpCas9	negative selection	867425
64485459	64485482	12	-	26627737	GBM cells	viability after 5 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	-0.5204625601174957	[443]	[179,151]	-7	hSpCas9	negative selection	867426
64490053	64490076	12	+	26627737	GBM cells	viability after 5 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.4641131207854119	[97]	[61,82]	7	hSpCas9	negative selection	867427
64460236	64460259	12	-	26627737	GBM cells	viability after 13 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.6594813087574922	[356]	[147,101]	-7	hSpCas9	negative selection	949737
64474356	64474379	12	-	26627737	GBM cells	viability after 13 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.4496904788104078	[409]	[206,126]	-5	hSpCas9	negative selection	949738
64480070	64480093	12	+	26627737	GBM cells	viability after 13 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	-0.3243587070041468	[148]	[95,38]	-4	hSpCas9	negative selection	949739
64484379	64484402	12	+	26627737	GBM cells	viability after 13 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.02348314026413978	[565]	[305,298]	0	hSpCas9	negative selection	949740
64485459	64485482	12	-	26627737	GBM cells	viability after 13 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	-0.5693883732854339	[443]	[163,160]	-6	hSpCas9	negative selection	949741
64490053	64490076	12	+	26627737	GBM cells	viability after 13 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.02342152037325551	[97]	[64,41]	0	hSpCas9	negative selection	949742
64460236	64460259	12	-	26627737	GBM cells	viability after 21 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.5827386767268874	[356]	[152,107]	-5	hSpCas9	negative selection	1032052
64474356	64474379	12	-	26627737	GBM cells	viability after 21 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.018305401151518685	[409]	[246,205]	0	hSpCas9	negative selection	1032053
64480070	64480093	12	+	26627737	GBM cells	viability after 21 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	-0.3578436833965678	[148]	[70,55]	-3	hSpCas9	negative selection	1032054
64484379	64484402	12	+	26627737	GBM cells	viability after 21 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.15979707106306407	[565]	[280,269]	-1	hSpCas9	negative selection	1032055
64485459	64485482	12	-	26627737	GBM cells	viability after 21 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	-0.7266655292617584	[443]	[162,129]	-6	hSpCas9	negative selection	1032056
64490053	64490076	12	+	26627737	GBM cells	viability after 21 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.20255391118096622	[97]	[54,66]	2	hSpCas9	negative selection	1032057
64460236	64460259	12	-	26627737	RPE1	viability after 9 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.1602426919259522	[975]	[192,532]	1	hSpCas9	negative selection	1114367
64474356	64474379	12	-	26627737	RPE1	viability after 9 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.06403473171467744	[1182]	[338,373]	0	hSpCas9	negative selection	1114368
64480070	64480093	12	+	26627737	RPE1	viability after 9 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.8092077639609796	[214]	[151,73]	5	hSpCas9	negative selection	1114369
64484379	64484402	12	+	26627737	RPE1	viability after 9 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.03371036680063755	[1614]	[551,418]	0	hSpCas9	negative selection	1114370
64485459	64485482	12	-	26627737	RPE1	viability after 9 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.16396658914743464	[868]	[299,310]	1	hSpCas9	negative selection	1114371
64490053	64490076	12	+	26627737	RPE1	viability after 9 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-1.4174601935494453	[674]	[72,86]	-7	hSpCas9	negative selection	1114372
64460236	64460259	12	-	26627737	RPE1	viability after 12 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.046001285111101575	[975]	[192,352]	0	hSpCas9	negative selection	1196682
64474356	64474379	12	-	26627737	RPE1	viability after 12 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.1169441076342993	[1182]	[295,289]	-1	hSpCas9	negative selection	1196683
64480070	64480093	12	+	26627737	RPE1	viability after 12 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.4563876174623138	[214]	[104,51]	3	hSpCas9	negative selection	1196684
64484379	64484402	12	+	26627737	RPE1	viability after 12 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.06679340073529905	[1614]	[520,383]	0	hSpCas9	negative selection	1196685
64485459	64485482	12	-	26627737	RPE1	viability after 12 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	-0.166264946641714	[868]	[141,277]	-1	hSpCas9	negative selection	1196686
64490053	64490076	12	+	26627737	RPE1	viability after 12 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-1.12858644058336	[674]	[63,102]	-7	hSpCas9	negative selection	1196687
64460236	64460259	12	-	26627737	RPE1	viability after 15 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.10504134884680166	[975]	[160,348]	0	hSpCas9	negative selection	1278997
64474356	64474379	12	-	26627737	RPE1	viability after 15 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.2289899325670996	[1182]	[311,259]	-1	hSpCas9	negative selection	1278998
64480070	64480093	12	+	26627737	RPE1	viability after 15 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.5159366489754569	[214]	[116,57]	3	hSpCas9	negative selection	1278999
64484379	64484402	12	+	26627737	RPE1	viability after 15 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.11859383091587739	[1614]	[580,413]	0	hSpCas9	negative selection	1279000
64485459	64485482	12	-	26627737	RPE1	viability after 15 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.12443081773097883	[868]	[269,265]	0	hSpCas9	negative selection	1279001
64490053	64490076	12	+	26627737	RPE1	viability after 15 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.8679500026490997	[674]	[153,56]	-5	hSpCas9	negative selection	1279002
64460236	64460259	12	-	26627737	RPE1	viability after 18 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.5512306266748488	[975]	[84,280]	-3	hSpCas9	negative selection	1361312
64474356	64474379	12	-	26627737	RPE1	viability after 18 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.3559852788253911	[1182]	[276,219]	-2	hSpCas9	negative selection	1361313
64480070	64480093	12	+	26627737	RPE1	viability after 18 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	-0.12070457122831102	[214]	[63,41]	0	hSpCas9	negative selection	1361314
64484379	64484402	12	+	26627737	RPE1	viability after 18 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.44582839786213935	[1614]	[670,510]	3	hSpCas9	negative selection	1361315
64485459	64485482	12	-	26627737	RPE1	viability after 18 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	-0.35814320288449386	[868]	[108,261]	-2	hSpCas9	negative selection	1361316
64490053	64490076	12	+	26627737	RPE1	viability after 18 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.8850466285679434	[674]	[87,109]	-5	hSpCas9	negative selection	1361317
64460236	64460259	12	-	26627737	HeLa	viability after 8 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.5275899269942063	[384]	[97,120,124]	-5	hSpCas9	negative selection	1443627
64474356	64474379	12	-	26627737	HeLa	viability after 8 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.37362863134157326	[426]	[354,205,189]	3	hSpCas9	negative selection	1443628
64480070	64480093	12	+	26627737	HeLa	viability after 8 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	-0.14967235181882466	[206]	[71,79,88]	-1	hSpCas9	negative selection	1443629
64484379	64484402	12	+	26627737	HeLa	viability after 8 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.8797392293397152	[1341]	[331,271,348]	-7	hSpCas9	negative selection	1443630
64485459	64485482	12	-	26627737	HeLa	viability after 8 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.5097468876207498	[345]	[273,223,161]	4	hSpCas9	negative selection	1443631
64490053	64490076	12	+	26627737	HeLa	viability after 8 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.8887878017999786	[149]	[33,43,27]	-7	hSpCas9	negative selection	1443632
64460236	64460259	12	-	26627737	HeLa	viability after 12 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.0946802334930256	[384]	[88,141,214]	-1	hSpCas9	negative selection	1525942
64474356	64474379	12	-	26627737	HeLa	viability after 12 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.4936613164111892	[426]	[168,286,282]	4	hSpCas9	negative selection	1525943
64480070	64480093	12	+	26627737	HeLa	viability after 12 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.24711958631451947	[206]	[80,91,131]	2	hSpCas9	negative selection	1525944
64484379	64484402	12	+	26627737	HeLa	viability after 12 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.11607103175295674	[1341]	[481,410,651]	-1	hSpCas9	negative selection	1525945
64485459	64485482	12	-	26627737	HeLa	viability after 12 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.8249267589789031	[345]	[296,235,229]	6	hSpCas9	negative selection	1525946
64490053	64490076	12	+	26627737	HeLa	viability after 12 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.8384574812523615	[149]	[74,7,24]	-6	hSpCas9	negative selection	1525947
64460236	64460259	12	-	26627737	HeLa	viability after 15 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.03877415084195585	[384]	[197,129,153]	0	hSpCas9	negative selection	1608257
64474356	64474379	12	-	26627737	HeLa	viability after 15 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.10893776682379748	[426]	[157,262,137]	0	hSpCas9	negative selection	1608258
64480070	64480093	12	+	26627737	HeLa	viability after 15 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.4951789771765572	[206]	[95,76,188]	4	hSpCas9	negative selection	1608259
64484379	64484402	12	+	26627737	HeLa	viability after 15 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.06512970872655588	[1341]	[363,400,826]	0	hSpCas9	negative selection	1608260
64485459	64485482	12	-	26627737	HeLa	viability after 15 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.2481815236807827	[345]	[170,209,116]	2	hSpCas9	negative selection	1608261
64490053	64490076	12	+	26627737	HeLa	viability after 15 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-1.9522750479021695	[149]	[31,12,0]	-9	hSpCas9	negative selection	1608262
64460236	64460259	12	-	26627737	HeLa	viability after 18 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.012901835453894495	[384]	[126,107,153]	0	hSpCas9	negative selection	1690572
64474356	64474379	12	-	26627737	HeLa	viability after 18 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.1339242127137566	[426]	[108,221,137]	1	hSpCas9	negative selection	1690573
64480070	64480093	12	+	26627737	HeLa	viability after 18 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.48880027677583066	[206]	[63,62,188]	4	hSpCas9	negative selection	1690574
64484379	64484402	12	+	26627737	HeLa	viability after 18 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.06635567933480635	[1341]	[240,334,826]	0	hSpCas9	negative selection	1690575
64485459	64485482	12	-	26627737	HeLa	viability after 18 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.2856240278224178	[345]	[119,177,116]	2	hSpCas9	negative selection	1690576
64490053	64490076	12	+	26627737	HeLa	viability after 18 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-1.8212747051030824	[149]	[24,9,0]	-9	hSpCas9	negative selection	1690577
64460236	64460259	12	-	26627737	HCT116	viability after 6 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.8436822733774604	[721]	[50,69]	-5	hSpCas9	negative selection	1772887
64474356	64474379	12	-	26627737	HCT116	viability after 6 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.20217320460404953	[617]	[48,103]	-1	hSpCas9	negative selection	1772888
64480070	64480093	12	+	26627737	HCT116	viability after 6 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	1.9292858508155821	[228]	[120,145]	8	hSpCas9	negative selection	1772889
64484379	64484402	12	+	26627737	HCT116	viability after 6 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.5893077825445172	[1438]	[340,339]	3	hSpCas9	negative selection	1772890
64485459	64485482	12	-	26627737	HCT116	viability after 6 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	1.292192941653446	[722]	[278,277]	7	hSpCas9	negative selection	1772891
64490053	64490076	12	+	26627737	HCT116	viability after 6 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.2878073959504641	[232]	[0,45]	-2	hSpCas9	negative selection	1772892
64460236	64460259	12	-	26627737	HCT116	viability after 8 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.26493726456012956	[261]	[262,166,92]	3	hSpCas9	negative selection	1855202
64474356	64474379	12	-	26627737	HCT116	viability after 8 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.4205815640848407	[547]	[206,286,182]	-5	hSpCas9	negative selection	1855203
64480070	64480093	12	+	26627737	HCT116	viability after 8 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	-1.168325583904517	[280]	[90,40,74]	-8	hSpCas9	negative selection	1855204
64484379	64484402	12	+	26627737	HCT116	viability after 8 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.47419410476970747	[527]	[536,285,391]	5	hSpCas9	negative selection	1855205
64485459	64485482	12	-	26627737	HCT116	viability after 8 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	-0.1803765468221048	[484]	[261,293,152]	-2	hSpCas9	negative selection	1855206
64490053	64490076	12	+	26627737	HCT116	viability after 8 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.9189862110221327	[138]	[18,49,51]	-8	hSpCas9	negative selection	1855207
64460236	64460259	12	-	26627737	HCT116	viability after 9 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-1.0518461665997585	[721]	[135,58]	-6	hSpCas9	negative selection	1937517
64474356	64474379	12	-	26627737	HCT116	viability after 9 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.565981359837678	[617]	[168,65]	-4	hSpCas9	negative selection	1937518
64480070	64480093	12	+	26627737	HCT116	viability after 9 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	1.3372069882415007	[228]	[82,210]	8	hSpCas9	negative selection	1937519
64484379	64484402	12	+	26627737	HCT116	viability after 9 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.7601716831298695	[1438]	[189,255]	-5	hSpCas9	negative selection	1937520
64485459	64485482	12	-	26627737	HCT116	viability after 9 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	1.323501641608193	[722]	[204,702]	8	hSpCas9	negative selection	1937521
64490053	64490076	12	+	26627737	HCT116	viability after 9 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-3.170529432147984	[232]	[2,9]	-9	hSpCas9	negative selection	1937522
64460236	64460259	12	-	26627737	HCT116	viability after 12 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.5377623687397804	[261]	[208,205,183]	5	hSpCas9	negative selection	2019832
64474356	64474379	12	-	26627737	HCT116	viability after 12 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.4368612512322114	[547]	[151,229,261]	-5	hSpCas9	negative selection	2019833
64480070	64480093	12	+	26627737	HCT116	viability after 12 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	-0.6297758045546751	[280]	[66,61,158]	-6	hSpCas9	negative selection	2019834
64484379	64484402	12	+	26627737	HCT116	viability after 12 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.4141118190485128	[527]	[274,306,533]	4	hSpCas9	negative selection	2019835
64485459	64485482	12	-	26627737	HCT116	viability after 12 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	-0.5322406251813827	[484]	[154,233,142]	-5	hSpCas9	negative selection	2019836
64490053	64490076	12	+	26627737	HCT116	viability after 12 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.7974162168867018	[138]	[64,38,19]	-7	hSpCas9	negative selection	2019837
64460236	64460259	12	-	26627737	HCT116	viability after 15 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.0199937533427601	[261]	[122,162,155]	0	hSpCas9	negative selection	2102147
64474356	64474379	12	-	26627737	HCT116	viability after 15 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.49528645957071116	[547]	[158,281,220]	-5	hSpCas9	negative selection	2102148
64480070	64480093	12	+	26627737	HCT116	viability after 15 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	-0.8020589343758207	[280]	[158,54,71]	-7	hSpCas9	negative selection	2102149
64484379	64484402	12	+	26627737	HCT116	viability after 15 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.48616858550484243	[527]	[455,395,425]	4	hSpCas9	negative selection	2102150
64485459	64485482	12	-	26627737	HCT116	viability after 15 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	-0.18197712470781802	[484]	[219,228,283]	-2	hSpCas9	negative selection	2102151
64490053	64490076	12	+	26627737	HCT116	viability after 15 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.7422570274169102	[138]	[39,35,65]	-6	hSpCas9	negative selection	2102152
64460236	64460259	12	-	26627737	HCT116	viability after 18 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.2143709506802105	[261]	[204,121,113]	2	hSpCas9	negative selection	2184462
64474356	64474379	12	-	26627737	HCT116	viability after 18 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.3506089306351715	[547]	[214,198,209]	-3	hSpCas9	negative selection	2184463
64480070	64480093	12	+	26627737	HCT116	viability after 18 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	-1.2014839970770013	[280]	[109,39,26]	-8	hSpCas9	negative selection	2184464
64484379	64484402	12	+	26627737	HCT116	viability after 18 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.40647173569665795	[527]	[377,304,333]	3	hSpCas9	negative selection	2184465
64485459	64485482	12	-	26627737	HCT116	viability after 18 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	-0.41622345210588135	[484]	[101,189,236]	-4	hSpCas9	negative selection	2184466
64490053	64490076	12	+	26627737	HCT116	viability after 18 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.17271071946871008	[138]	[65,89,18]	-1	hSpCas9	negative selection	2184467
64455875	64455898	12	+	24336569	HL60	viability	AGAGCACTTCTAATCATCTGTGG	TBK1	ENSG00000183735	-0.5229738112689312	[1099]	[1619]	-5	hSpCas9	negative selection	2299111
64455918	64455941	12	-	24336569	HL60	viability	AGACATTTGCAGTAGCTCCTTGG	TBK1	ENSG00000183735	0.18277055073243542	[800]	[1923]	1	hSpCas9	negative selection	2299112
64455925	64455948	12	+	24336569	HL60	viability	GCTACTGCAAATGTCTTTCGTGG	TBK1	ENSG00000183735	-0.0702890250722189	[642]	[1295]	0	hSpCas9	negative selection	2299113
64455936	64455959	12	+	24336569	HL60	viability	TGTCTTTCGTGGAAGACATAAGG	TBK1	ENSG00000183735	0.10988533731542743	[556]	[1271]	1	hSpCas9	negative selection	2299114
64460227	64460250	12	+	24336569	HL60	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.19116802005462663	[238]	[442]	-2	hSpCas9	negative selection	2299115
64460236	64460259	12	-	24336569	HL60	viability	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.31118155291019844	[1266]	[2160]	-3	hSpCas9	negative selection	2299116
64460243	64460266	12	-	24336569	HL60	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.25077821185140015	[445]	[1122]	2	hSpCas9	negative selection	2299117
64460305	64460328	12	+	24336569	HL60	viability	CAAATTATTTGCTATTGAAGAGG	TBK1	ENSG00000183735	-0.6989292410373817	[302]	[394]	-6	hSpCas9	negative selection	2299118
64464342	64464365	12	+	24336569	HL60	viability	AAGACATAAAGTACTTATTATGG	TBK1	ENSG00000183735	-0.2729625140195605	[1077]	[1887]	-2	hSpCas9	negative selection	2299119
64464373	64464396	12	-	24336569	HL60	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.15281131222347355	[569]	[1340]	1	hSpCas9	negative selection	2299120
64455875	64455898	12	+	24336569	KBM7	viability	AGAGCACTTCTAATCATCTGTGG	TBK1	ENSG00000183735	0.17208046461904236	[670]	[2061]	1	hSpCas9	negative selection	2366288
64455918	64455941	12	-	24336569	KBM7	viability	AGACATTTGCAGTAGCTCCTTGG	TBK1	ENSG00000183735	0.11965021824725097	[572]	[1697]	1	hSpCas9	negative selection	2366289
64455925	64455948	12	+	24336569	KBM7	viability	GCTACTGCAAATGTCTTTCGTGG	TBK1	ENSG00000183735	0.06388248325404355	[556]	[1587]	0	hSpCas9	negative selection	2366290
64455936	64455959	12	+	24336569	KBM7	viability	TGTCTTTCGTGGAAGACATAAGG	TBK1	ENSG00000183735	-0.07614705843442215	[549]	[1422]	0	hSpCas9	negative selection	2366291
64460227	64460250	12	+	24336569	KBM7	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.25854537215886575	[99]	[227]	-2	hSpCas9	negative selection	2366292
64460236	64460259	12	-	24336569	KBM7	viability	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.47755051734467835	[785]	[2984]	4	hSpCas9	negative selection	2366293
64460243	64460266	12	-	24336569	KBM7	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	-0.008901397976493535	[400]	[1086]	0	hSpCas9	negative selection	2366294
64460305	64460328	12	+	24336569	KBM7	viability	CAAATTATTTGCTATTGAAGAGG	TBK1	ENSG00000183735	0.11697709351043661	[355]	[1052]	1	hSpCas9	negative selection	2366295
64464342	64464365	12	+	24336569	KBM7	viability	AAGACATAAAGTACTTATTATGG	TBK1	ENSG00000183735	0.5480556108897155	[661]	[2639]	5	hSpCas9	negative selection	2366296
64464373	64464396	12	-	24336569	KBM7	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.3135553207385072	[366]	[1243]	3	hSpCas9	negative selection	2366297
64499771	64499794	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACTGCAACCTCCACCTCCCGAG	TBK1	ENSG00000183735	-1.4516426362223873	[480,182]	[29,20]	-8	dCas9-VP64	positive selection	2427028
64499771	64499794	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACTGCAACCTCCACCTCCCGAG	TBK1	ENSG00000183735	1.047613524569726	[257,163]	[245,45]	6	dCas9-VP64	positive selection	2522283
64480031	64480054	12	+	27260157	DLD1	viability	AAGCCTTCTGGTGCAATATCTGG	TBK1	ENSG00000183735	-0.531283189940076	[]	[]	-4	hSpCas9	negative selection	2574636
64464373	64464396	12	-	27260157	DLD1	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.00619273361895654	[]	[]	0	hSpCas9	negative selection	2578411
64474325	64474348	12	-	27260157	DLD1	viability	GCAGTGATCCAGTAGCTGCATGG	TBK1	ENSG00000183735	0.333391385848733	[]	[]	4	hSpCas9	negative selection	2579346
64455925	64455948	12	+	27260157	DLD1	viability	GCTACTGCAAATGTCTTTCGTGG	TBK1	ENSG00000183735	0.425598483862343	[]	[]	7	hSpCas9	negative selection	2584165
64474354	64474377	12	+	27260157	DLD1	viability	GACCCTTTGAAGGGCCTCGTAGG	TBK1	ENSG00000183735	0.0247904645082018	[]	[]	0	hSpCas9	negative selection	2585884
64466936	64466959	12	+	27260157	DLD1	viability	GTGCACCGTGATATCAAGCCAGG	TBK1	ENSG00000183735	0.952270993405587	[]	[]	9	hSpCas9	negative selection	2586322
64480034	64480057	12	-	27260157	DLD1	viability	ACTCCAGATATTGCACCAGAAGG	TBK1	ENSG00000183735	0.544848789101718	[]	[]	8	hSpCas9	negative selection	2605110
64455875	64455898	12	+	27260157	DLD1	viability	AGAGCACTTCTAATCATCTGTGG	TBK1	ENSG00000183735	0.108495751125457	[]	[]	3	hSpCas9	negative selection	2606003
64460305	64460328	12	+	27260157	DLD1	viability	CAAATTATTTGCTATTGAAGAGG	TBK1	ENSG00000183735	-0.338115573582962	[]	[]	-3	hSpCas9	negative selection	2609330
64460227	64460250	12	+	27260157	DLD1	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.025032783233999	[]	[]	0	hSpCas9	negative selection	2609826
64455856	64455879	12	-	27260157	DLD1	viability	CTCTGCATCTTGGCTGGATCAGG	TBK1	ENSG00000183735	1.10511497283713	[]	[]	9	hSpCas9	negative selection	2610407
64474347	64474370	12	-	27260157	DLD1	viability	GGCCCTTCAAAGGGTCTAAATGG	TBK1	ENSG00000183735	0.741239903310338	[]	[]	8	hSpCas9	negative selection	2611150
64455918	64455941	12	-	27260157	DLD1	viability	AGACATTTGCAGTAGCTCCTTGG	TBK1	ENSG00000183735	-0.220425101663794	[]	[]	-2	hSpCas9	negative selection	2612233
64474357	64474380	12	-	27260157	DLD1	viability	ATTCCTACGAGGCCCTTCAAAGG	TBK1	ENSG00000183735	0.742201791919317	[]	[]	8	hSpCas9	negative selection	2614356
64460236	64460259	12	-	27260157	DLD1	viability	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	1.32898986100388	[]	[]	9	hSpCas9	negative selection	2616366
64460243	64460266	12	-	27260157	DLD1	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	1.12790101951937	[]	[]	9	hSpCas9	negative selection	2641814
64474344	64474367	12	+	27260157	DLD1	viability	CTGCCATTTAGACCCTTTGAAGG	TBK1	ENSG00000183735	0.59498031385041	[]	[]	8	hSpCas9	negative selection	2646648
64464406	64464429	12	-	27260157	DLD1	viability	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	-0.228820868101415	[]	[]	-2	hSpCas9	negative selection	2648142
64480031	64480054	12	+	27260157	HT1080	viability	AAGCCTTCTGGTGCAATATCTGG	TBK1	ENSG00000183735	0.0249247357588107	[]	[]	0	hSpCas9	negative selection	2650766
64464373	64464396	12	-	27260157	HT1080	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.373507721452558	[]	[]	3	hSpCas9	negative selection	2654541
64474325	64474348	12	-	27260157	HT1080	viability	GCAGTGATCCAGTAGCTGCATGG	TBK1	ENSG00000183735	1.63652412881924	[]	[]	9	hSpCas9	negative selection	2655476
64455925	64455948	12	+	27260157	HT1080	viability	GCTACTGCAAATGTCTTTCGTGG	TBK1	ENSG00000183735	0.028429320160427	[]	[]	0	hSpCas9	negative selection	2660295
64474354	64474377	12	+	27260157	HT1080	viability	GACCCTTTGAAGGGCCTCGTAGG	TBK1	ENSG00000183735	-1.8428045785368	[]	[]	-9	hSpCas9	negative selection	2662014
64466936	64466959	12	+	27260157	HT1080	viability	GTGCACCGTGATATCAAGCCAGG	TBK1	ENSG00000183735	1.59239892076938	[]	[]	9	hSpCas9	negative selection	2662452
64480034	64480057	12	-	27260157	HT1080	viability	ACTCCAGATATTGCACCAGAAGG	TBK1	ENSG00000183735	0.459767853562444	[]	[]	4	hSpCas9	negative selection	2681240
64455875	64455898	12	+	27260157	HT1080	viability	AGAGCACTTCTAATCATCTGTGG	TBK1	ENSG00000183735	-0.231862422994631	[]	[]	0	hSpCas9	negative selection	2682133
64460305	64460328	12	+	27260157	HT1080	viability	CAAATTATTTGCTATTGAAGAGG	TBK1	ENSG00000183735	0.721896102938871	[]	[]	6	hSpCas9	negative selection	2685460
64460227	64460250	12	+	27260157	HT1080	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.85465901876206	[]	[]	-8	hSpCas9	negative selection	2685956
64455856	64455879	12	-	27260157	HT1080	viability	CTCTGCATCTTGGCTGGATCAGG	TBK1	ENSG00000183735	0.219063100674561	[]	[]	2	hSpCas9	negative selection	2686537
64474347	64474370	12	-	27260157	HT1080	viability	GGCCCTTCAAAGGGTCTAAATGG	TBK1	ENSG00000183735	0.590785826829661	[]	[]	5	hSpCas9	negative selection	2687280
64455918	64455941	12	-	27260157	HT1080	viability	AGACATTTGCAGTAGCTCCTTGG	TBK1	ENSG00000183735	-0.0155550354615638	[]	[]	0	hSpCas9	negative selection	2688363
64474357	64474380	12	-	27260157	HT1080	viability	ATTCCTACGAGGCCCTTCAAAGG	TBK1	ENSG00000183735	0.566006958924827	[]	[]	5	hSpCas9	negative selection	2690486
64460236	64460259	12	-	27260157	HT1080	viability	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-1.03011499877429	[]	[]	-8	hSpCas9	negative selection	2692496
64460243	64460266	12	-	27260157	HT1080	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.140713778880668	[]	[]	1	hSpCas9	negative selection	2717944
64474344	64474367	12	+	27260157	HT1080	viability	CTGCCATTTAGACCCTTTGAAGG	TBK1	ENSG00000183735	0.268899213709176	[]	[]	2	hSpCas9	negative selection	2722778
64464406	64464429	12	-	27260157	HT1080	viability	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	-0.0745804232389149	[]	[]	0	hSpCas9	negative selection	2724272
64480031	64480054	12	+	27260157	MKN45	viability	AAGCCTTCTGGTGCAATATCTGG	TBK1	ENSG00000183735	-0.0725228207708815	[]	[]	0	hSpCas9	negative selection	2726896
64464373	64464396	12	-	27260157	MKN45	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.909425297642336	[]	[]	-7	hSpCas9	negative selection	2730671
64474325	64474348	12	-	27260157	MKN45	viability	GCAGTGATCCAGTAGCTGCATGG	TBK1	ENSG00000183735	0.35304878750432	[]	[]	6	hSpCas9	negative selection	2731606
64455925	64455948	12	+	27260157	MKN45	viability	GCTACTGCAAATGTCTTTCGTGG	TBK1	ENSG00000183735	0.113289060581376	[]	[]	4	hSpCas9	negative selection	2736425
64474354	64474377	12	+	27260157	MKN45	viability	GACCCTTTGAAGGGCCTCGTAGG	TBK1	ENSG00000183735	-0.27268119958639	[]	[]	-1	hSpCas9	negative selection	2738144
64466936	64466959	12	+	27260157	MKN45	viability	GTGCACCGTGATATCAAGCCAGG	TBK1	ENSG00000183735	0.93123120293314	[]	[]	8	hSpCas9	negative selection	2738582
64480034	64480057	12	-	27260157	MKN45	viability	ACTCCAGATATTGCACCAGAAGG	TBK1	ENSG00000183735	0.852207863500562	[]	[]	8	hSpCas9	negative selection	2757370
64455875	64455898	12	+	27260157	MKN45	viability	AGAGCACTTCTAATCATCTGTGG	TBK1	ENSG00000183735	0.180581497916545	[]	[]	5	hSpCas9	negative selection	2758263
64460305	64460328	12	+	27260157	MKN45	viability	CAAATTATTTGCTATTGAAGAGG	TBK1	ENSG00000183735	-0.287125575124808	[]	[]	-1	hSpCas9	negative selection	2761590
64460227	64460250	12	+	27260157	MKN45	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.142301590570858	[]	[]	0	hSpCas9	negative selection	2762086
64455856	64455879	12	-	27260157	MKN45	viability	CTCTGCATCTTGGCTGGATCAGG	TBK1	ENSG00000183735	0.897636446821619	[]	[]	8	hSpCas9	negative selection	2762667
64474347	64474370	12	-	27260157	MKN45	viability	GGCCCTTCAAAGGGTCTAAATGG	TBK1	ENSG00000183735	0.422461112866528	[]	[]	6	hSpCas9	negative selection	2763410
64455918	64455941	12	-	27260157	MKN45	viability	AGACATTTGCAGTAGCTCCTTGG	TBK1	ENSG00000183735	-0.277343414493535	[]	[]	-1	hSpCas9	negative selection	2764493
64474357	64474380	12	-	27260157	MKN45	viability	ATTCCTACGAGGCCCTTCAAAGG	TBK1	ENSG00000183735	-0.237912379462357	[]	[]	-1	hSpCas9	negative selection	2766616
64460236	64460259	12	-	27260157	MKN45	viability	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.100103535420036	[]	[]	0	hSpCas9	negative selection	2768626
64460243	64460266	12	-	27260157	MKN45	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	-1.21185039942492	[]	[]	-8	hSpCas9	negative selection	2794074
64474344	64474367	12	+	27260157	MKN45	viability	CTGCCATTTAGACCCTTTGAAGG	TBK1	ENSG00000183735	0.178136116383737	[]	[]	5	hSpCas9	negative selection	2798908
64464406	64464429	12	-	27260157	MKN45	viability	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	-0.930452422176274	[]	[]	-7	hSpCas9	negative selection	2800402
64480031	64480054	12	+	27260157	RKO	viability	AAGCCTTCTGGTGCAATATCTGG	TBK1	ENSG00000183735	-0.154458517170765	[]	[]	0	hSpCas9	negative selection	2803026
64464373	64464396	12	-	27260157	RKO	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.633482464347389	[]	[]	-7	hSpCas9	negative selection	2806801
64474325	64474348	12	-	27260157	RKO	viability	GCAGTGATCCAGTAGCTGCATGG	TBK1	ENSG00000183735	0.397972757422478	[]	[]	2	hSpCas9	negative selection	2807736
64455925	64455948	12	+	27260157	RKO	viability	GCTACTGCAAATGTCTTTCGTGG	TBK1	ENSG00000183735	-0.545516582864975	[]	[]	-7	hSpCas9	negative selection	2812555
64474354	64474377	12	+	27260157	RKO	viability	GACCCTTTGAAGGGCCTCGTAGG	TBK1	ENSG00000183735	0.462452074453518	[]	[]	2	hSpCas9	negative selection	2814274
64466936	64466959	12	+	27260157	RKO	viability	GTGCACCGTGATATCAAGCCAGG	TBK1	ENSG00000183735	0.786900823396789	[]	[]	8	hSpCas9	negative selection	2814712
64480034	64480057	12	-	27260157	RKO	viability	ACTCCAGATATTGCACCAGAAGG	TBK1	ENSG00000183735	0.495838531388194	[]	[]	2	hSpCas9	negative selection	2833500
64455875	64455898	12	+	27260157	RKO	viability	AGAGCACTTCTAATCATCTGTGG	TBK1	ENSG00000183735	0.345040451348405	[]	[]	1	hSpCas9	negative selection	2834393
64460305	64460328	12	+	27260157	RKO	viability	CAAATTATTTGCTATTGAAGAGG	TBK1	ENSG00000183735	0.125258065407721	[]	[]	0	hSpCas9	negative selection	2837720
64460227	64460250	12	+	27260157	RKO	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-1.14916270508375	[]	[]	-8	hSpCas9	negative selection	2838216
64455856	64455879	12	-	27260157	RKO	viability	CTCTGCATCTTGGCTGGATCAGG	TBK1	ENSG00000183735	0.23773088257627	[]	[]	1	hSpCas9	negative selection	2838797
64474347	64474370	12	-	27260157	RKO	viability	GGCCCTTCAAAGGGTCTAAATGG	TBK1	ENSG00000183735	0.594998582803152	[]	[]	3	hSpCas9	negative selection	2839540
64455918	64455941	12	-	27260157	RKO	viability	AGACATTTGCAGTAGCTCCTTGG	TBK1	ENSG00000183735	0.0175422290855705	[]	[]	0	hSpCas9	negative selection	2840623
64474357	64474380	12	-	27260157	RKO	viability	ATTCCTACGAGGCCCTTCAAAGG	TBK1	ENSG00000183735	0.0435439169963575	[]	[]	0	hSpCas9	negative selection	2842746
64460236	64460259	12	-	27260157	RKO	viability	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.0753281130332453	[]	[]	0	hSpCas9	negative selection	2844756
64460243	64460266	12	-	27260157	RKO	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	-0.260985321226317	[]	[]	-1	hSpCas9	negative selection	2870204
64474344	64474367	12	+	27260157	RKO	viability	CTGCCATTTAGACCCTTTGAAGG	TBK1	ENSG00000183735	-0.165175417253073	[]	[]	-1	hSpCas9	negative selection	2875038
64464406	64464429	12	-	27260157	RKO	viability	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	-0.479358683911263	[]	[]	-6	hSpCas9	negative selection	2876532
64480031	64480054	12	+	27260157	SF268	viability	AAGCCTTCTGGTGCAATATCTGG	TBK1	ENSG00000183735	0.647144054459625	[]	[]	8	hSpCas9	negative selection	2879156
64464373	64464396	12	-	27260157	SF268	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.605841127452748	[]	[]	8	hSpCas9	negative selection	2882931
64474325	64474348	12	-	27260157	SF268	viability	GCAGTGATCCAGTAGCTGCATGG	TBK1	ENSG00000183735	0.542578185833628	[]	[]	8	hSpCas9	negative selection	2883866
64455925	64455948	12	+	27260157	SF268	viability	GCTACTGCAAATGTCTTTCGTGG	TBK1	ENSG00000183735	-0.378599100386436	[]	[]	-3	hSpCas9	negative selection	2888685
64474354	64474377	12	+	27260157	SF268	viability	GACCCTTTGAAGGGCCTCGTAGG	TBK1	ENSG00000183735	-1.47129985988343	[]	[]	-8	hSpCas9	negative selection	2890404
64466936	64466959	12	+	27260157	SF268	viability	GTGCACCGTGATATCAAGCCAGG	TBK1	ENSG00000183735	0.297204812141347	[]	[]	4	hSpCas9	negative selection	2890842
64480034	64480057	12	-	27260157	SF268	viability	ACTCCAGATATTGCACCAGAAGG	TBK1	ENSG00000183735	0.61954594003185	[]	[]	8	hSpCas9	negative selection	2909630
64455875	64455898	12	+	27260157	SF268	viability	AGAGCACTTCTAATCATCTGTGG	TBK1	ENSG00000183735	0.819413702273164	[]	[]	8	hSpCas9	negative selection	2910523
64460305	64460328	12	+	27260157	SF268	viability	CAAATTATTTGCTATTGAAGAGG	TBK1	ENSG00000183735	0.0186031313301743	[]	[]	0	hSpCas9	negative selection	2913850
64460227	64460250	12	+	27260157	SF268	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.164806837155932	[]	[]	0	hSpCas9	negative selection	2914346
64455856	64455879	12	-	27260157	SF268	viability	CTCTGCATCTTGGCTGGATCAGG	TBK1	ENSG00000183735	1.48659484707338	[]	[]	9	hSpCas9	negative selection	2914927
64474347	64474370	12	-	27260157	SF268	viability	GGCCCTTCAAAGGGTCTAAATGG	TBK1	ENSG00000183735	0.778747165963152	[]	[]	8	hSpCas9	negative selection	2915670
64455918	64455941	12	-	27260157	SF268	viability	AGACATTTGCAGTAGCTCCTTGG	TBK1	ENSG00000183735	0.663417022706965	[]	[]	8	hSpCas9	negative selection	2916753
64474357	64474380	12	-	27260157	SF268	viability	ATTCCTACGAGGCCCTTCAAAGG	TBK1	ENSG00000183735	0.294691953713553	[]	[]	4	hSpCas9	negative selection	2918876
64460236	64460259	12	-	27260157	SF268	viability	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.10323281432045	[]	[]	-1	hSpCas9	negative selection	2920886
64460243	64460266	12	-	27260157	SF268	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.243663973116809	[]	[]	3	hSpCas9	negative selection	2946334
64474344	64474367	12	+	27260157	SF268	viability	CTGCCATTTAGACCCTTTGAAGG	TBK1	ENSG00000183735	-0.429378621178216	[]	[]	-3	hSpCas9	negative selection	2951168
64464406	64464429	12	-	27260157	SF268	viability	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	0.252388680110067	[]	[]	4	hSpCas9	negative selection	2952662
64464400	64464423	12	+	27013184	SW480	treatment with recombinant TRAIL	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.40359045556461637	[286,205]	[133,6]	-2	hSpCas9	positive selection	2965556
64455875	64455898	12	+	27013184	SW480	treatment with recombinant TRAIL	AGAGCACTTCTAATCATCTGTGG	TBK1	ENSG00000183735	1.1206275444370384	[190,232]	[171,232]	5	hSpCas9	positive selection	2965557
64455866	64455889	12	-	27013184	SW480	treatment with recombinant TRAIL	ATTAGAAGTGCTCTGCATCTTGG	TBK1	ENSG00000183735	1.0186255112455078	[301,260]	[276,205]	5	hSpCas9	positive selection	2965558
64455918	64455941	12	-	27013184	SW480	treatment with recombinant TRAIL	AGACATTTGCAGTAGCTCCTTGG	TBK1	ENSG00000183735	0.3353210930741446	[653,1077]	[485,425]	1	hSpCas9	positive selection	2965559
64460236	64460259	12	-	27013184	SW480	treatment with recombinant TRAIL	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.2090829998740865	[139,278]	[39,126]	-1	hSpCas9	positive selection	2965560
64484303	64484326	12	+	27013184	SW480	treatment with recombinant TRAIL	TGCTACTATATTTCATGAACTGG	TBK1	ENSG00000183735	0.7109948731117068	[38,25]	[17,30]	3	hSpCas9	positive selection	2965561
64460243	64460266	12	-	27013184	SW480	treatment with recombinant TRAIL	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	-0.7533890582775815	[813,1036]	[195,288]	-3	hSpCas9	positive selection	2965562
64484355	64484378	12	+	27013184	SW480	treatment with recombinant TRAIL	AATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	0.021859507720568994	[57,52]	[23,24]	0	hSpCas9	positive selection	2965563
64484379	64484402	12	+	27013184	SW480	treatment with recombinant TRAIL	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.3486881646281208	[98,199]	[37,64]	-1	hSpCas9	positive selection	2965564
64484383	64484406	12	+	27013184	SW480	treatment with recombinant TRAIL	GCTTAGTCTTAGAACCTGGAAGG	TBK1	ENSG00000183735	-0.5648303949922291	[354,524]	[107,151]	-3	hSpCas9	positive selection	2965565
64484387	64484410	12	+	27013184	SW480	treatment with recombinant TRAIL	AGTCTTAGAACCTGGAAGGCTGG	TBK1	ENSG00000183735	-0.26528953114259335	[250,271]	[107,72]	-1	hSpCas9	positive selection	2965566
64484414	64484437	12	+	27013184	SW480	treatment with recombinant TRAIL	ACATTTCCCTAAAACTACTGAGG	TBK1	ENSG00000183735	1.4599606250382626	[157,120]	[129,220]	6	hSpCas9	positive selection	2965567
64484440	64484463	12	+	27013184	SW480	treatment with recombinant TRAIL	ACCCTATATTTGTAGTAAGCCGG	TBK1	ENSG00000183735	-3.7303110693549324	[462,573]	[19,11]	-9	hSpCas9	positive selection	2965568
64455901	64455924	12	+	27013184	SW480	treatment with recombinant TRAIL	TTATCTGATATTTTAGGCCAAGG	TBK1	ENSG00000183735	-1.8046000384175098	[171,93]	[1,37]	-7	hSpCas9	positive selection	2965569
64484441	64484464	12	+	27013184	SW480	treatment with recombinant TRAIL	CCCTATATTTGTAGTAAGCCGGG	TBK1	ENSG00000183735	-0.3074778323060319	[201,141]	[50,74]	-1	hSpCas9	positive selection	2965570
64484460	64484483	12	+	27013184	SW480	treatment with recombinant TRAIL	CGGGAACCTCTGAATACCATAGG	TBK1	ENSG00000183735	-1.2444055408590016	[534,490]	[106,74]	-5	hSpCas9	positive selection	2965571
64485486	64485509	12	+	27013184	SW480	treatment with recombinant TRAIL	TTTAGACGGGGATGCTAGCATGG	TBK1	ENSG00000183735	1.615553748564756	[117,188]	[230,152]	7	hSpCas9	positive selection	2965572
64455925	64455948	12	+	27013184	SW480	treatment with recombinant TRAIL	GCTACTGCAAATGTCTTTCGTGG	TBK1	ENSG00000183735	0.8482291806735467	[161,242]	[104,224]	4	hSpCas9	positive selection	2965573
64484397	64484420	12	-	27013184	SW480	treatment with recombinant TRAIL	AAATGTTGTGCCAGCCTTCCAGG	TBK1	ENSG00000183735	-0.10683108581448386	[580,650]	[160,365]	0	hSpCas9	positive selection	2965574
64484420	64484443	12	-	27013184	SW480	treatment with recombinant TRAIL	GGTTTTCCTCAGTAGTTTTAGGG	TBK1	ENSG00000183735	0.20902314701117808	[381,522]	[170,295]	1	hSpCas9	positive selection	2965575
64484441	64484464	12	-	27013184	SW480	treatment with recombinant TRAIL	CCCGGCTTACTACAAATATAGGG	TBK1	ENSG00000183735	1.3964282149498204	[30,1]	[32,1]	6	hSpCas9	positive selection	2965576
64484442	64484465	12	-	27013184	SW480	treatment with recombinant TRAIL	TCCCGGCTTACTACAAATATAGG	TBK1	ENSG00000183735	1.4055668151615666	[358,471]	[219,823]	6	hSpCas9	positive selection	2965577
64484459	64484482	12	-	27013184	SW480	treatment with recombinant TRAIL	CTATGGTATTCAGAGGTTCCCGG	TBK1	ENSG00000183735	0.6293299314290142	[9,37]	[8,23]	3	hSpCas9	positive selection	2965578
64484466	64484489	12	-	27013184	SW480	treatment with recombinant TRAIL	ATTAATCCTATGGTATTCAGAGG	TBK1	ENSG00000183735	-0.3560592777254554	[56,52]	[11,27]	-1	hSpCas9	positive selection	2965579
64485463	64485486	12	-	27013184	SW480	treatment with recombinant TRAIL	TCATAACGTGGATGTACTTTAGG	TBK1	ENSG00000183735	2.393328784387166	[188,331]	[673,436]	8	hSpCas9	positive selection	2965580
64460227	64460250	12	+	27013184	SW480	treatment with recombinant TRAIL	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.07747034022922128	[337,310]	[144,152]	0	hSpCas9	positive selection	2965581
64464373	64464396	12	-	27013184	SW480	treatment with recombinant TRAIL	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-1.3483086614153956	[16,42]	[1,8]	-6	hSpCas9	positive selection	2965582
64464406	64464429	12	-	27013184	SW480	treatment with recombinant TRAIL	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	1.1717368525803074	[135,171]	[129,173]	5	hSpCas9	positive selection	2965583
64455856	64455879	12	-	27013184	SW480	treatment with recombinant TRAIL	CTCTGCATCTTGGCTGGATCAGG	TBK1	ENSG00000183735	-1.1243151285443098	[319,516]	[83,76]	-5	hSpCas9	positive selection	2965584
64455862	64455885	12	-	27013184	SW480	treatment with recombinant TRAIL	GAAGTGCTCTGCATCTTGGCTGG	TBK1	ENSG00000183735	0.07806165193556569	[404,476]	[139,283]	0	hSpCas9	positive selection	2965585
64474325	64474348	12	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCAGTGATCCAGTAGCTGCATGG	TBK1	ENSG00000183735	-0.4127729739983428	[3,3]	[4,0]	-5	hSpCas9	positive selection	3025709
64464406	64464429	12	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	-0.3082645238399313	[3,3]	[3,1]	-4	hSpCas9	positive selection	3025710
64474346	64474369	12	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGCCATTTAGACCCTTTGAAGGG	TBK1	ENSG00000183735	0.17823629030555838	[5,5]	[5,4]	4	hSpCas9	positive selection	3025711
64474356	64474379	12	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.043768369691177436	[3,3]	[2,3]	0	hSpCas9	positive selection	3025712
64474325	64474348	12	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCAGTGATCCAGTAGCTGCATGG	TBK1	ENSG00000183735	-0.6120813890878829	[3,3]	[2,0]	-8	hSpCas9	positive selection	3093567
64464406	64464429	12	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	-0.2820989014457245	[3,3]	[3,0]	-4	hSpCas9	positive selection	3093568
64474346	64474369	12	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGCCATTTAGACCCTTTGAAGGG	TBK1	ENSG00000183735	0.16798231503722733	[5,5]	[4,3]	3	hSpCas9	positive selection	3093569
64474356	64474379	12	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.011973900081759886	[3,3]	[4,1]	0	hSpCas9	positive selection	3093570
64460227	64460250		+	24336571	A375	resistance to PLX after 7 days	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.8586896621870327	[5,5]	[7,13]	9	hSpCas9	positive selection	3149254
64464441	64464464		+	24336571	A375	resistance to PLX after 7 days	CTTAATTGTTTTGCGAGATGTGG	TBK1	ENSG00000183735	-0.3167016442838356	[14,10]	[9,10]	-8	hSpCas9	positive selection	3149255
64464400	64464423		+	24336571	A375	resistance to PLX after 7 days	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.42072243533875475	[5,7]	[4,4]	-9	hSpCas9	positive selection	3149256
64460227	64460250		+	24336571	A375	resistance to PLX after 14 days	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	1.9916060797671846	[6,8]	[19,9]	9	hSpCas9	positive selection	3207047
64464441	64464464		+	24336571	A375	resistance to PLX after 14 days	CTTAATTGTTTTGCGAGATGTGG	TBK1	ENSG00000183735	-0.11254678803248794	[12,12]	[4,5]	-1	hSpCas9	positive selection	3207048
64464400	64464423		+	24336571	A375	resistance to PLX after 14 days	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	0.06883596926435476	[2,6]	[1,1]	0	hSpCas9	positive selection	3207049
64460227	64460250		+	24336571	A375	viability after 7 days	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.28157406089386783	[7]	[5,5]	-4	hSpCas9	negative selection	3264840
64464441	64464464		+	24336571	A375	viability after 7 days	CTTAATTGTTTTGCGAGATGTGG	TBK1	ENSG00000183735	0.25192092321114096	[10]	[14,10]	4	hSpCas9	negative selection	3264841
64464400	64464423		+	24336571	A375	viability after 7 days	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.09249803845584847	[7]	[5,7]	-1	hSpCas9	negative selection	3264842
64460227	64460250		+	24336571	A375	viability after 14 days	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.1112716249422282	[7]	[6,8]	1	hSpCas9	negative selection	3322633
64464441	64464464		+	24336571	A375	viability after 14 days	CTTAATTGTTTTGCGAGATGTGG	TBK1	ENSG00000183735	0.3151445854669264	[10]	[12,12]	4	hSpCas9	negative selection	3322634
64464400	64464423		+	24336571	A375	viability after 14 days	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.5718000204811028	[7]	[2,6]	-6	hSpCas9	negative selection	3322635
64474290	64474313	12	+	27383988	293T	resistance to West Nile virus (flavivirus)	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	1.0478728458168853	[73,73]	[0,0]	5	hSpCas9	positive selection	3396378
64460243	64460266	12	-	27383988	293T	resistance to West Nile virus (flavivirus)	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	-1.753901043977419	[515,515]	[0,0]	-9	hSpCas9	positive selection	3396379
64464373	64464396	12	-	27383988	293T	resistance to West Nile virus (flavivirus)	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-1.0914019427852424	[325,325]	[0,0]	-7	hSpCas9	positive selection	3396380
64474325	64474348	12	-	26780180	HT29	viability (Avana library 4 designs)	GCAGTGATCCAGTAGCTGCATGG	TBK1	ENSG00000183735	0.506593774450005	[]	[]	2	hSpCas9	negative selection	3464419
64464406	64464429	12	-	26780180	HT29	viability (Avana library 4 designs)	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	0.624499425790442	[]	[]	2	hSpCas9	negative selection	3464420
64474345	64474368	12	+	26780180	HT29	viability (Avana library 4 designs)	TGCCATTTAGACCCTTTGAAGGG	TBK1	ENSG00000183735	-0.985219306044032	[]	[]	-9	hSpCas9	negative selection	3464421
64474356	64474379	12	-	26780180	HT29	viability (Avana library 4 designs)	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.502110925704119	[]	[]	-7	hSpCas9	negative selection	3464422
64474325	64474348	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGTGATCCAGTAGCTGCATGG	TBK1	ENSG00000183735	2.72934897227038	[]	[]	4	hSpCas9	negative selection	3567104
64474345	64474368	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	TGCCATTTAGACCCTTTGAAGGG	TBK1	ENSG00000183735	-1.23691586664792	[]	[]	-1	hSpCas9	negative selection	3567105
64474356	64474379	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-4.61036537291303	[]	[]	-5	hSpCas9	negative selection	3567106
64464406	64464429	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	-4.477501431654	[]	[]	-5	hSpCas9	negative selection	3567107
64481888	64481911	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGATCAGGAAAAGTGTTGGGG	TBK1	ENSG00000183735	-0.903642166121762	[]	[]	-1	hSpCas9	negative selection	3567108
64481862	64481885	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	0.404202921706521	[]	[]	0	hSpCas9	negative selection	3567109
64474325	64474348	12	-	26780180	A375	viability (Avana lentiGuide)	GCAGTGATCCAGTAGCTGCATGG	TBK1	ENSG00000183735	-2.29038994462748	[]	[]	-4	hSpCas9	negative selection	3675763
64474345	64474368	12	+	26780180	A375	viability (Avana lentiGuide)	TGCCATTTAGACCCTTTGAAGGG	TBK1	ENSG00000183735	-1.82560606011475	[]	[]	-3	hSpCas9	negative selection	3675764
64474356	64474379	12	-	26780180	A375	viability (Avana lentiGuide)	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	4.59596415563183	[]	[]	4	hSpCas9	negative selection	3675765
64464406	64464429	12	-	26780180	A375	viability (Avana lentiGuide)	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	2.97172310228161	[]	[]	3	hSpCas9	negative selection	3675766
64481888	64481911	12	+	26780180	A375	viability (Avana lentiGuide)	GCAGATCAGGAAAAGTGTTGGGG	TBK1	ENSG00000183735	-0.153366921828964	[]	[]	0	hSpCas9	negative selection	3675767
64481862	64481885	12	-	26780180	A375	viability (Avana lentiGuide)	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	1.8086258009579	[]	[]	2	hSpCas9	negative selection	3675768
64474325	64474348	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGTGATCCAGTAGCTGCATGG	TBK1	ENSG00000183735	0.10717921616220469	[4]	[5,4]	3	hSpCas9	positive selection	3784370
64474345	64474368	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGCCATTTAGACCCTTTGAAGGG	TBK1	ENSG00000183735	-0.14838370866048103	[6]	[5,5]	-2	hSpCas9	positive selection	3784371
64474356	64474379	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.15496749983581387	[5]	[4,4]	-3	hSpCas9	positive selection	3784372
64464406	64464429	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	-0.13442816194627352	[5]	[3,5]	-2	hSpCas9	positive selection	3784373
64481888	64481911	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGATCAGGAAAAGTGTTGGGG	TBK1	ENSG00000183735	-0.10813782104619703	[5]	[5,3]	-2	hSpCas9	positive selection	3784374
64481862	64481885	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	0.03268087500438638	[5]	[5,5]	0	hSpCas9	positive selection	3784375
64474325	64474348	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGTGATCCAGTAGCTGCATGG	TBK1	ENSG00000183735	0.19496905818646532	[5]	[5,4]	5	hSpCas9	positive selection	3892977
64474345	64474368	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGCCATTTAGACCCTTTGAAGGG	TBK1	ENSG00000183735	-0.054555099495748244	[6]	[4,5]	-1	hSpCas9	positive selection	3892978
64474356	64474379	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.16971619692542655	[5]	[4,3]	-2	hSpCas9	positive selection	3892979
64464406	64464429	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGTAGTCCATAGGCATTAGAAGG	TBK1	ENSG00000183735	0.19418454867518142	[5]	[5,4]	5	hSpCas9	positive selection	3892980
64481888	64481911	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGATCAGGAAAAGTGTTGGGG	TBK1	ENSG00000183735	0.31464170693471977	[5]	[6,5]	8	hSpCas9	positive selection	3892981
64481862	64481885	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	-0.07505774056432357	[5]	[4,3]	-1	hSpCas9	positive selection	3892982
64464373	64464396	12	-	26780180	A375	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	1.36502185113505	[]	[]	7	hSpCas9	negative selection	4002384
64474290	64474313	12	+	26780180	A375	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	1.23118697702931	[]	[]	6	hSpCas9	negative selection	4002385
64474368	64474391	12	-	26780180	A375	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	1.06299212771949	[]	[]	5	hSpCas9	negative selection	4002386
64460227	64460250	12	+	26780180	A375	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.878576656427825	[]	[]	3	hSpCas9	negative selection	4002387
64464400	64464423	12	+	26780180	A375	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	1.60646014248949	[]	[]	8	hSpCas9	negative selection	4002388
64460243	64460266	12	-	26780180	A375	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.759077784658519	[]	[]	3	hSpCas9	negative selection	4002389
64464373	64464396	12	-	26780180	HT29	viability (GeCKOv2 library)	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.188133880291289	[]	[]	0	hSpCas9	negative selection	4110350
64474290	64474313	12	+	26780180	HT29	viability (GeCKOv2 library)	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	1.83306699384916	[]	[]	8	hSpCas9	negative selection	4110351
64474368	64474391	12	-	26780180	HT29	viability (GeCKOv2 library)	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	0.850908073332857	[]	[]	3	hSpCas9	negative selection	4110352
64460227	64460250	12	+	26780180	HT29	viability (GeCKOv2 library)	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.726883855237691	[]	[]	3	hSpCas9	negative selection	4110353
64464400	64464423	12	+	26780180	HT29	viability (GeCKOv2 library)	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	0.996772610844594	[]	[]	4	hSpCas9	negative selection	4110354
64460243	64460266	12	-	26780180	HT29	viability (GeCKOv2 library)	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.239559766384308	[]	[]	0	hSpCas9	negative selection	4110355
64460227	64460250	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.3654717821370198	[2]	[1,3]	8	hSpCas9	positive selection	4175585
64464441	64464464	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTTAATTGTTTTGCGAGATGTGG	TBK1	ENSG00000183735	-0.022292645029426385	[3]	[1,2]	0	hSpCas9	positive selection	4175586
64464400	64464423	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.04265864512341161	[2]	[2,0]	-1	hSpCas9	positive selection	4175587
64460227	64460250	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	1.319171808803754	[2]	[2,1,1,2]	9	hSpCas9	positive selection	4239607
64464441	64464464	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTTAATTGTTTTGCGAGATGTGG	TBK1	ENSG00000183735	0.17581801286198323	[2]	[0,2,1,0]	1	hSpCas9	positive selection	4239608
64464400	64464423	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.2786249131013587	[2]	[0,2,0,0]	-4	hSpCas9	positive selection	4239609
64474368	64474391	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	0.2537540371159852	[3]	[3,2]	5	hSpCas9	positive selection	4302223
64460227	64460250	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.48869463573220506	[1]	[1,0]	-8	hSpCas9	positive selection	4302224
64464400	64464423	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.04490754224523634	[3]	[3,1]	-1	hSpCas9	positive selection	4302225
64474290	64474313	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.563592435737496	[2]	[1,0]	-8	hSpCas9	positive selection	4366477
64460243	64460266	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.17922422163736063	[4]	[3,3]	3	hSpCas9	positive selection	4366478
64464373	64464396	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.0034840979135978833	[4]	[3,2]	0	hSpCas9	positive selection	4366479
64466910	64466932	12	+	27760321	OCIAML3	viability	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	1.0065574787753697	[62,66]	[67,147]	9	hSpCas9	negative selection	4445630
64474356	64474378	12	-	27760321	OCIAML3	viability	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.7745399792806107	[188,167]	[214,268]	8	hSpCas9	negative selection	4445631
64481936	64481958	12	+	27760321	OCIAML3	viability	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	1.0888756725660649	[48,48]	[53,117]	9	hSpCas9	negative selection	4445632
64484356	64484378	12	+	27760321	OCIAML3	viability	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	0.5370224922975244	[50,22]	[9,80]	6	hSpCas9	negative selection	4445633
64484380	64484402	12	+	27760321	OCIAML3	viability	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-1.6748192978541834	[334,304]	[73,83]	-8	hSpCas9	negative selection	4445634
64466910	64466932	12	+	27760321	OCIAML2	viability	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	-0.9864840044740024	[62,66]	[8,49]	-7	hSpCas9	negative selection	4529093
64474356	64474378	12	-	27760321	OCIAML2	viability	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.5990129557791876	[188,167]	[245,181]	7	hSpCas9	negative selection	4529094
64481936	64481958	12	+	27760321	OCIAML2	viability	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	0.8850686323468135	[48,48]	[28,131]	9	hSpCas9	negative selection	4529095
64484356	64484378	12	+	27760321	OCIAML2	viability	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	-0.6847441337644486	[50,22]	[2,37]	-6	hSpCas9	negative selection	4529096
64484380	64484402	12	+	27760321	OCIAML2	viability	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.1258852515321358	[334,304]	[221,256]	-2	hSpCas9	negative selection	4529097
64466910	64466932	12	+	27760321	MV411	viability	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	0.4890221769776488	[62,66]	[0,149]	3	hSpCas9	negative selection	4612556
64474356	64474378	12	-	27760321	MV411	viability	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	1.6336254428297396	[188,167]	[527,119]	9	hSpCas9	negative selection	4612557
64481936	64481958	12	+	27760321	MV411	viability	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	-0.22390205977343713	[48,48]	[0,67]	-2	hSpCas9	negative selection	4612558
64484356	64484378	12	+	27760321	MV411	viability	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	-1.6424437951489237	[50,22]	[11,0]	-8	hSpCas9	negative selection	4612559
64484380	64484402	12	+	27760321	MV411	viability	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.5616870227168113	[334,304]	[199,478]	4	hSpCas9	negative selection	4612560
64466910	64466932	12	+	27760321	HL60	viability	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	-1.8068936630210923	[62,66]	[23,5]	-9	hSpCas9	negative selection	4696019
64474356	64474378	12	-	27760321	HL60	viability	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.7655551996389779	[188,167]	[230,264]	8	hSpCas9	negative selection	4696020
64481936	64481958	12	+	27760321	HL60	viability	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	0.4894993397591323	[48,48]	[68,42]	6	hSpCas9	negative selection	4696021
64484356	64484378	12	+	27760321	HL60	viability	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	0.0934551446278653	[50,22]	[42,18]	1	hSpCas9	negative selection	4696022
64484380	64484402	12	+	27760321	HL60	viability	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.31207086589938166	[334,304]	[169,487]	4	hSpCas9	negative selection	4696023
64466910	64466932	12	+	27760321	HT1080	viability	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	-4.566502377495997	[66,51]	[0,0]	-8	hSpCas9	negative selection	4779482
64474356	64474378	12	-	27760321	HT1080	viability	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.016305209805825616	[167,130]	[43,77]	0	hSpCas9	negative selection	4779483
64481936	64481958	12	+	27760321	HT1080	viability	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	-4.114558017842154	[48,37]	[0,0]	-8	hSpCas9	negative selection	4779484
64484356	64484378	12	+	27760321	HT1080	viability	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	2.0319767200671217	[22,17]	[62,0]	9	hSpCas9	negative selection	4779485
64484380	64484402	12	+	27760321	HT1080	viability	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.7701878378731233	[304,237]	[14,369]	4	hSpCas9	negative selection	4779486
64466910	64466932	12	+	27760321	HT29	viability after 7 days	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	0.5143166120493499	[66,51]	[185,59,92]	7	hSpCas9	negative selection	4862945
64474356	64474378	12	-	27760321	HT29	viability after 7 days	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.6028197523029992	[167,130]	[301,323,251]	8	hSpCas9	negative selection	4862946
64481936	64481958	12	+	27760321	HT29	viability after 7 days	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	-2.294072466435102	[48,37]	[14,17,1]	-9	hSpCas9	negative selection	4862947
64484356	64484378	12	+	27760321	HT29	viability after 7 days	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	0.7017410830101589	[22,17]	[0,27,91]	9	hSpCas9	negative selection	4862948
64484380	64484402	12	+	27760321	HT29	viability after 7 days	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.1493943227569734	[304,237]	[412,269,275]	-2	hSpCas9	negative selection	4862949
64466910	64466932	12	+	27760321	HT29	viability after 25 days	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	-0.10353793228365893	[66,51]	[79,50,56]	-1	hSpCas9	negative selection	4946408
64474356	64474378	12	-	27760321	HT29	viability after 25 days	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	1.2469419565336606	[167,130]	[387,189,665]	9	hSpCas9	negative selection	4946409
64481936	64481958	12	+	27760321	HT29	viability after 25 days	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	-0.19932040938563578	[48,37]	[76,12,36]	-2	hSpCas9	negative selection	4946410
64484356	64484378	12	+	27760321	HT29	viability after 25 days	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	1.261860502358401	[22,17]	[48,45,75]	9	hSpCas9	negative selection	4946411
64484380	64484402	12	+	27760321	HT29	viability after 25 days	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.13508121354690894	[304,237]	[357,153,335]	-1	hSpCas9	negative selection	4946412
64466910	64466932	12	+	27760321	HT29	viability after 22 days	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	-0.8310334056288426	[66,51]	[3,62,49]	-6	hSpCas9	negative selection	5029871
64474356	64474378	12	-	27760321	HT29	viability after 22 days	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.9699647094909906	[167,130]	[337,187,490]	9	hSpCas9	negative selection	5029872
64481936	64481958	12	+	27760321	HT29	viability after 22 days	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	-0.09009889122595238	[48,37]	[70,25,43]	-1	hSpCas9	negative selection	5029873
64484356	64484378	12	+	27760321	HT29	viability after 22 days	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	0.13172650021337695	[22,17]	[1,3,72]	1	hSpCas9	negative selection	5029874
64484380	64484402	12	+	27760321	HT29	viability after 22 days	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.18215991448405866	[304,237]	[344,210,271]	-2	hSpCas9	negative selection	5029875
64466910	64466932	12	+	27760321	HT29	viability after 19 days	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	0.619708136305841	[66,51]	[78,104,125]	6	hSpCas9	negative selection	5113334
64474356	64474378	12	-	27760321	HT29	viability after 19 days	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.7577687105032977	[167,130]	[377,91,401]	7	hSpCas9	negative selection	5113335
64481936	64481958	12	+	27760321	HT29	viability after 19 days	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	-0.2841903809031536	[48,37]	[87,13,25]	-3	hSpCas9	negative selection	5113336
64484356	64484378	12	+	27760321	HT29	viability after 19 days	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	0.5734589073217822	[22,17]	[14,63,23]	6	hSpCas9	negative selection	5113337
64484380	64484402	12	+	27760321	HT29	viability after 19 days	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.6490669799729707	[304,237]	[318,47,237]	-5	hSpCas9	negative selection	5113338
64466910	64466932	12	+	27760321	HT29	viability after 16 days	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	0.8153266342578267	[66,51]	[90,224,29]	8	hSpCas9	negative selection	5196797
64474356	64474378	12	-	27760321	HT29	viability after 16 days	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	1.2974575652250515	[167,130]	[463,457,314]	9	hSpCas9	negative selection	5196798
64481936	64481958	12	+	27760321	HT29	viability after 16 days	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	0.026381476863471143	[48,37]	[110,27,15]	0	hSpCas9	negative selection	5196799
64484356	64484378	12	+	27760321	HT29	viability after 16 days	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	1.007732641789881	[22,17]	[18,76,38]	9	hSpCas9	negative selection	5196800
64484380	64484402	12	+	27760321	HT29	viability after 16 days	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.9935684481006002	[304,237]	[220,79,164]	-7	hSpCas9	negative selection	5196801
64466910	64466932	12	+	27760321	HT29	viability after 13 days	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	0.9401297816284528	[66,51]	[230,136,34]	9	hSpCas9	negative selection	5280260
64474356	64474378	12	-	27760321	HT29	viability after 13 days	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	1.2052306738118896	[167,130]	[489,439,276]	9	hSpCas9	negative selection	5280261
64481936	64481958	12	+	27760321	HT29	viability after 13 days	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	-0.7366030652832274	[48,37]	[12,49,27]	-6	hSpCas9	negative selection	5280262
64484356	64484378	12	+	27760321	HT29	viability after 13 days	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	0.30509706352380084	[22,17]	[2,17,64]	4	hSpCas9	negative selection	5280263
64484380	64484402	12	+	27760321	HT29	viability after 13 days	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.14148139754063627	[304,237]	[153,299,395]	-2	hSpCas9	negative selection	5280264
64466910	64466932	12	+	27760321	HT29	viability after 10 days	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	0.5317873062862031	[66,51]	[247,62,11]	7	hSpCas9	negative selection	5363723
64474356	64474378	12	-	27760321	HT29	viability after 10 days	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	1.052780312547209	[167,130]	[352,230,568]	9	hSpCas9	negative selection	5363724
64481936	64481958	12	+	27760321	HT29	viability after 10 days	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	-2.0315527111351894	[48,37]	[27,9,1]	-9	hSpCas9	negative selection	5363725
64484356	64484378	12	+	27760321	HT29	viability after 10 days	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	-0.3241104543866058	[22,17]	[32,27,0]	-4	hSpCas9	negative selection	5363726
64484380	64484402	12	+	27760321	HT29	viability after 10 days	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.1779653182412515	[304,237]	[319,323,501]	2	hSpCas9	negative selection	5363727
64466910	64466932	12	+	27760321	MOLM13	viability	TGAATCATCTACGAGAGAATGG	TBK1	ENSG00000183735	-5.204989894583353	[62,66]	[0,0]	-9	hSpCas9	negative selection	5447186
64474356	64474378	12	-	27760321	MOLM13	viability	TCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.5063991776551211	[188,167]	[113,33]	-3	hSpCas9	negative selection	5447187
64481936	64481958	12	+	27760321	MOLM13	viability	AGTGATATACTTCACCGAATGG	TBK1	ENSG00000183735	-2.536354556963363	[48,48]	[0,7]	-8	hSpCas9	negative selection	5447188
64484356	64484378	12	+	27760321	MOLM13	viability	ATCAAGAACTTATCTACGAAGG	TBK1	ENSG00000183735	1.1438087005044637	[50,22]	[93,2]	7	hSpCas9	negative selection	5447189
64484380	64484402	12	+	27760321	MOLM13	viability	GACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-1.7314001678853783	[334,304]	[116,0]	-7	hSpCas9	negative selection	5447190
64474368	64474391	12	-	27260156	BXPC3	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.19952041969086576	[682]	[469,716,605,711]	-4	hSpCas9	negative selection	5574683
64460227	64460250	12	+	27260156	BXPC3	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.21848725258877888	[133]	[69,149,272,171]	5	hSpCas9	negative selection	5574684
64464400	64464423	12	+	27260156	BXPC3	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.10109616530426448	[502]	[464,457,579,456]	-2	hSpCas9	negative selection	5574685
64474290	64474313	12	+	27260156	BXPC3	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.3501910806418813	[239]	[129,230,233,196]	-7	hSpCas9	negative selection	5638937
64460243	64460266	12	-	27260156	BXPC3	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.019971137235251568	[1315]	[1483,1127,1498,1477]	0	hSpCas9	negative selection	5638938
64464373	64464396	12	-	27260156	BXPC3	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.23904153580875387	[1129]	[842,964,1058,1171]	-5	hSpCas9	negative selection	5638939
64474368	64474391	12	-	27260156	A673	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.29435256043922486	[682]	[823,706,435,728]	-6	hSpCas9	negative selection	5695934
64460227	64460250	12	+	27260156	A673	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.028496048758032133	[133]	[164,207,168,109]	0	hSpCas9	negative selection	5695935
64464400	64464423	12	+	27260156	A673	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.17023591118029396	[502]	[654,492,479,532]	-4	hSpCas9	negative selection	5695936
64474290	64474313	12	+	27260156	A673	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.2796772708853128	[239]	[221,254,230,238]	-6	hSpCas9	negative selection	5760188
64460243	64460266	12	-	27260156	A673	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.17910719922933005	[1315]	[1820,1676,1745,1922]	4	hSpCas9	negative selection	5760189
64464373	64464396	12	-	27260156	A673	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.09324107125735481	[1129]	[1226,1203,1285,1369]	-2	hSpCas9	negative selection	5760190
64474368	64474391	12	-	27260156	A375	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.16348195958872214	[682]	[780,1019,647,469]	-2	hSpCas9	negative selection	5817185
64460227	64460250	12	+	27260156	A375	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.3409929921026338	[133]	[126,203,105,73]	-5	hSpCas9	negative selection	5817186
64464400	64464423	12	+	27260156	A375	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.7395711651733461	[502]	[288,598,264,293]	-7	hSpCas9	negative selection	5817187
64474290	64474313	12	+	27260156	A375	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.4688700702856201	[239]	[153,215,220,217]	-6	hSpCas9	negative selection	5881439
64460243	64460266	12	-	27260156	A375	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	-0.060025111778534646	[1315]	[1486,1685,1204,1535]	-1	hSpCas9	negative selection	5881440
64464373	64464396	12	-	27260156	A375	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.4551213254513866	[1129]	[741,1241,868,1023]	-6	hSpCas9	negative selection	5881441
64474368	64474391	12	-	27260156	COLO741	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.15121331646237712	[682]	[869,710,781]	-3	hSpCas9	negative selection	5938436
64460227	64460250	12	+	27260156	COLO741	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.06156405442143398	[133]	[132,146,205]	-1	hSpCas9	negative selection	5938437
64464400	64464423	12	+	27260156	COLO741	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.21458508176803942	[502]	[482,582,585]	-4	hSpCas9	negative selection	5938438
64474290	64474313	12	+	27260156	COLO741	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.8786959649466055	[239]	[189,132,177]	-9	hSpCas9	negative selection	6002690
64460243	64460266	12	-	27260156	COLO741	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.18094265689160904	[1315]	[2006,2289,1459]	4	hSpCas9	negative selection	6002691
64464373	64464396	12	-	27260156	COLO741	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.18889222851294596	[1129]	[1310,1296,1197]	-4	hSpCas9	negative selection	6002692
64474368	64474391	12	-	27260156	CAL120	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.341380298084774	[682]	[471,1046,466]	-5	hSpCas9	negative selection	6059687
64460227	64460250	12	+	27260156	CAL120	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.005055413955347143	[133]	[143,123,225]	0	hSpCas9	negative selection	6059688
64464400	64464423	12	+	27260156	CAL120	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.342644847240802	[502]	[786,481,259]	-5	hSpCas9	negative selection	6059689
64474290	64474313	12	+	27260156	CAL120	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-1.3221045004918122	[239]	[115,190,51]	-9	hSpCas9	negative selection	6123941
64460243	64460266	12	-	27260156	CAL120	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	-0.2167337961546285	[1315]	[1630,1200,1427]	-3	hSpCas9	negative selection	6123942
64464373	64464396	12	-	27260156	CAL120	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.7280616759410244	[1129]	[947,858,755]	-7	hSpCas9	negative selection	6123943
64474368	64474391	12	-	27260156	CADOES1	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.2119272629612623	[682]	[485,528,652,524]	-4	hSpCas9	negative selection	6180938
64460227	64460250	12	+	27260156	CADOES1	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.04570604690847624	[133]	[172,72,147,119]	0	hSpCas9	negative selection	6180939
64464400	64464423	12	+	27260156	CADOES1	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	0.22126462627715843	[502]	[521,561,565,530]	4	hSpCas9	negative selection	6180940
64474290	64474313	12	+	27260156	CADOES1	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.5533575934478898	[239]	[129,111,172,194]	-7	hSpCas9	negative selection	6245192
64460243	64460266	12	-	27260156	CADOES1	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.19874031016471694	[1315]	[1201,1425,1444,1551]	3	hSpCas9	negative selection	6245193
64464373	64464396	12	-	27260156	CADOES1	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.046388003571006475	[1129]	[1091,1211,1015,1018]	0	hSpCas9	negative selection	6245194
64474368	64474391	12	-	27260156	EWS502	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.028368762517869683	[682]	[629,561,800,869]	0	hSpCas9	negative selection	6302189
64460227	64460250	12	+	27260156	EWS502	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.20246195789673505	[133]	[93,150,186,234]	3	hSpCas9	negative selection	6302190
64464400	64464423	12	+	27260156	EWS502	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	0.2081332826495249	[502]	[612,452,637,773]	3	hSpCas9	negative selection	6302191
64474290	64474313	12	+	27260156	EWS502	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.5557425832464364	[239]	[126,187,200,180]	-7	hSpCas9	negative selection	6366443
64460243	64460266	12	-	27260156	EWS502	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.16449257417134278	[1315]	[1350,1544,1615,1772]	3	hSpCas9	negative selection	6366444
64464373	64464396	12	-	27260156	EWS502	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.04934393610365451	[1129]	[1220,1155,1081,1153]	-1	hSpCas9	negative selection	6366445
64474368	64474391	12	-	27260156	EW8	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.24441957872166936	[682]	[502,395,359,629]	-4	hSpCas9	negative selection	6423440
64460227	64460250	12	+	27260156	EW8	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.10304914626524053	[133]	[160,96,140,67]	1	hSpCas9	negative selection	6423441
64464400	64464423	12	+	27260156	EW8	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.45207832996903874	[502]	[370,346,283,199]	-7	hSpCas9	negative selection	6423442
64474290	64474313	12	+	27260156	EW8	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.7574140700201768	[239]	[134,51,106,168]	-8	hSpCas9	negative selection	6487694
64460243	64460266	12	-	27260156	EW8	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.112915947719755	[1315]	[1410,1225,880,1166]	2	hSpCas9	negative selection	6487695
64464373	64464396	12	-	27260156	EW8	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.16205800397989645	[1129]	[1119,826,689,689]	-3	hSpCas9	negative selection	6487696
64474368	64474391	12	-	27260156	CORL105	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.10486644812545959	[682]	[814,667,813,691]	-2	hSpCas9	negative selection	6544691
64460227	64460250	12	+	27260156	CORL105	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.32202791950646326	[133]	[106,96,183,122]	-5	hSpCas9	negative selection	6544692
64464400	64464423	12	+	27260156	CORL105	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.2451727075114351	[502]	[553,562,469,396]	-4	hSpCas9	negative selection	6544693
64474290	64474313	12	+	27260156	CORL105	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.32746668672634716	[239]	[206,161,180,338]	-6	hSpCas9	negative selection	6608945
64460243	64460266	12	-	27260156	CORL105	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.07326887986168296	[1315]	[1472,1601,1904,1542]	1	hSpCas9	negative selection	6608946
64464373	64464396	12	-	27260156	CORL105	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.11853422479201714	[1129]	[1044,1178,1495,1191]	-2	hSpCas9	negative selection	6608947
64474368	64474391	12	-	27260156	HS294T	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.554757236336218	[682]	[145,184,198,193]	-7	hSpCas9	negative selection	6665942
64460227	64460250	12	+	27260156	HS294T	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.33470970375918796	[133]	[62,22,33,42]	-5	hSpCas9	negative selection	6665943
64464400	64464423	12	+	27260156	HS294T	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.11214223744951314	[502]	[199,127,160,239]	-1	hSpCas9	negative selection	6665944
64474290	64474313	12	+	27260156	HS294T	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.30263415119465176	[239]	[71,54,97,76]	-4	hSpCas9	negative selection	6730196
64460243	64460266	12	-	27260156	HS294T	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	-0.1871208781282825	[1315]	[346,446,489,524]	-3	hSpCas9	negative selection	6730197
64464373	64464396	12	-	27260156	HS294T	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.23805177014301737	[1129]	[300,334,299,588]	-3	hSpCas9	negative selection	6730198
64474368	64474391	12	-	27260156	HCC44	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.10796236123119979	[682]	[546,739,744,811]	-2	hSpCas9	negative selection	6787193
64460227	64460250	12	+	27260156	HCC44	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.9193379204974845	[133]	[85,41,91,106]	-8	hSpCas9	negative selection	6787194
64464400	64464423	12	+	27260156	HCC44	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.3805969082321735	[502]	[607,279,543,370]	-5	hSpCas9	negative selection	6787195
64474290	64474313	12	+	27260156	HCC44	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.25443530118998225	[239]	[239,200,198,266]	-4	hSpCas9	negative selection	6851447
64460243	64460266	12	-	27260156	HCC44	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	-0.029202407455027446	[1315]	[1137,1535,1971,1231]	0	hSpCas9	negative selection	6851448
64464373	64464396	12	-	27260156	HCC44	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.21414696700966473	[1129]	[843,792,1775,1120]	-3	hSpCas9	negative selection	6851449
64474368	64474391	12	-	27260156	G402	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.22177525473123033	[682]	[766,835,776,500]	-3	hSpCas9	negative selection	6908444
64460227	64460250	12	+	27260156	G402	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.7094133333231816	[133]	[105,48,25,210]	-7	hSpCas9	negative selection	6908445
64464400	64464423	12	+	27260156	G402	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-1.0485506524495145	[502]	[191,389,253,337]	-8	hSpCas9	negative selection	6908446
64474290	64474313	12	+	27260156	G402	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-1.1955496170737965	[239]	[154,193,68,101]	-8	hSpCas9	negative selection	6972698
64460243	64460266	12	-	27260156	G402	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.12191980170149042	[1315]	[1986,1967,1641,1447]	1	hSpCas9	negative selection	6972699
64464373	64464396	12	-	27260156	G402	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.043284614155708834	[1129]	[2304,990,1413,1086]	0	hSpCas9	negative selection	6972700
64474368	64474391	12	-	27260156	L33	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.11583752378074719	[682]	[657,219,488,548]	-3	hSpCas9	negative selection	7029695
64460227	64460250	12	+	27260156	L33	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.3751569746942378	[133]	[314,49,80,125]	7	hSpCas9	negative selection	7029696
64464400	64464423	12	+	27260156	L33	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.3293521023118188	[502]	[436,151,252,389]	-6	hSpCas9	negative selection	7029697
64474290	64474313	12	+	27260156	L33	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.26384504704331735	[239]	[225,67,87,265]	-6	hSpCas9	negative selection	7093949
64460243	64460266	12	-	27260156	L33	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	-0.050472666546521605	[1315]	[1339,533,815,1140]	-1	hSpCas9	negative selection	7093950
64464373	64464396	12	-	27260156	L33	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.006093978496405139	[1129]	[1150,427,666,1241]	0	hSpCas9	negative selection	7093951
64474368	64474391	12	-	27260156	K562	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	0.5567548169560685	[682]	[1265,1334,355,683]	7	hSpCas9	negative selection	7150946
64460227	64460250	12	+	27260156	K562	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.44117895962114595	[133]	[149,132,57,23]	-5	hSpCas9	negative selection	7150947
64464400	64464423	12	+	27260156	K562	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.23115375679223793	[502]	[383,401,335,396]	-3	hSpCas9	negative selection	7150948
64474290	64474313	12	+	27260156	K562	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	0.49619213738866047	[239]	[263,164,514,251]	6	hSpCas9	negative selection	7215200
64460243	64460266	12	-	27260156	K562	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.22874346752916597	[1315]	[1749,948,1660,1143]	3	hSpCas9	negative selection	7215201
64464373	64464396	12	-	27260156	K562	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.03225184869331765	[1129]	[1062,1152,679,1031]	0	hSpCas9	negative selection	7215202
64474368	64474391	12	-	27260156	HT29	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	0.0037301485948262325	[682]	[946,809,754,819]	0	hSpCas9	negative selection	7272197
64460227	64460250	12	+	27260156	HT29	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.14209335120643996	[133]	[196,166,129,218]	2	hSpCas9	negative selection	7272198
64464400	64464423	12	+	27260156	HT29	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.3026252357798101	[502]	[387,595,394,588]	-5	hSpCas9	negative selection	7272199
64474290	64474313	12	+	27260156	HT29	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.5216950641469411	[239]	[201,286,121,206]	-7	hSpCas9	negative selection	7336451
64460243	64460266	12	-	27260156	HT29	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.3888841042955069	[1315]	[1995,2337,1923,2115]	7	hSpCas9	negative selection	7336452
64464373	64464396	12	-	27260156	HT29	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.006721459608777236	[1129]	[1454,1484,1716,924]	0	hSpCas9	negative selection	7336453
64474368	64474391	12	-	27260156	MHHES1	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	0.16100428855962123	[682]	[1018,912,760,771]	3	hSpCas9	negative selection	7393448
64460227	64460250	12	+	27260156	MHHES1	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.2644899273162562	[133]	[174,141,119,259]	5	hSpCas9	negative selection	7393449
64464400	64464423	12	+	27260156	MHHES1	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	0.061730028654239225	[502]	[838,444,764,370]	1	hSpCas9	negative selection	7393450
64474290	64474313	12	+	27260156	MHHES1	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.5487023247386116	[239]	[307,191,101,154]	-8	hSpCas9	negative selection	7457702
64460243	64460266	12	-	27260156	MHHES1	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.3004944648482475	[1315]	[2334,1496,2119,1430]	5	hSpCas9	negative selection	7457703
64464373	64464396	12	-	27260156	MHHES1	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.005253965479076861	[1129]	[1565,1591,1214,839]	0	hSpCas9	negative selection	7457704
64474368	64474391	12	-	27260156	MEWO	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.12344095641065977	[682]	[527,644,574]	-3	hSpCas9	negative selection	7514699
64460227	64460250	12	+	27260156	MEWO	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.3582933488159883	[133]	[159,149,171]	7	hSpCas9	negative selection	7514700
64464400	64464423	12	+	27260156	MEWO	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	0.027712336110670907	[502]	[590,396,472]	0	hSpCas9	negative selection	7514701
64474290	64474313	12	+	27260156	MEWO	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.2547849334195076	[239]	[216,207,144]	-5	hSpCas9	negative selection	7578953
64460243	64460266	12	-	27260156	MEWO	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.33475731046726853	[1315]	[2164,1451,1159]	7	hSpCas9	negative selection	7578954
64464373	64464396	12	-	27260156	MEWO	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.1141367068506769	[1129]	[1226,888,862]	-2	hSpCas9	negative selection	7578955
64474368	64474391	12	-	27260156	LNCAPCLONEFGC	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.2143673171899083	[682]	[494,475,726,467]	-3	hSpCas9	negative selection	7635950
64460227	64460250	12	+	27260156	LNCAPCLONEFGC	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.37079206467121995	[133]	[201,199,129,87]	6	hSpCas9	negative selection	7635951
64464400	64464423	12	+	27260156	LNCAPCLONEFGC	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.16867862939306336	[502]	[409,334,561,341]	-3	hSpCas9	negative selection	7635952
64474290	64474313	12	+	27260156	LNCAPCLONEFGC	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	0.027120389609068818	[239]	[195,211,294,194]	0	hSpCas9	negative selection	7700204
64460243	64460266	12	-	27260156	LNCAPCLONEFGC	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	-0.03758500214625782	[1315]	[1101,970,1526,1112]	0	hSpCas9	negative selection	7700205
64464373	64464396	12	-	27260156	LNCAPCLONEFGC	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.20817824183515654	[1129]	[763,752,1041,1018]	-3	hSpCas9	negative selection	7700206
64474368	64474391	12	-	27260156	PANC0327	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.3161070952099368	[682]	[461,258,740,514]	-5	hSpCas9	negative selection	7757201
64460227	64460250	12	+	27260156	PANC0327	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.6636980215318808	[133]	[184,32,64,31]	-7	hSpCas9	negative selection	7757202
64464400	64464423	12	+	27260156	PANC0327	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	0.03544691281950814	[502]	[609,224,435,602]	0	hSpCas9	negative selection	7757203
64474290	64474313	12	+	27260156	PANC0327	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	0.222794024869297	[239]	[231,523,79,121]	3	hSpCas9	negative selection	7821455
64460243	64460266	12	-	27260156	PANC0327	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.2038202146294008	[1315]	[1212,1428,1096,1623]	3	hSpCas9	negative selection	7821456
64464373	64464396	12	-	27260156	PANC0327	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.11785837533570498	[1129]	[958,1159,690,861]	-2	hSpCas9	negative selection	7821457
64474368	64474391	12	-	27260156	NCIH2009	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.17304865236621075	[682]	[1124,670,799]	-2	hSpCas9	negative selection	7878452
64460227	64460250	12	+	27260156	NCIH2009	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.07667368333002855	[133]	[273,196,79]	-1	hSpCas9	negative selection	7878453
64464400	64464423	12	+	27260156	NCIH2009	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	0.16504387555260286	[502]	[743,997,607]	2	hSpCas9	negative selection	7878454
64474290	64474313	12	+	27260156	NCIH2009	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.545894562697927	[239]	[339,254,114]	-6	hSpCas9	negative selection	7942706
64460243	64460266	12	-	27260156	NCIH2009	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	-0.1347055010611744	[1315]	[1613,1641,1753]	-2	hSpCas9	negative selection	7942707
64464373	64464396	12	-	27260156	NCIH2009	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.07084521288247614	[1129]	[2136,1234,1264]	-1	hSpCas9	negative selection	7942708
64474368	64474391	12	-	27260156	NCIH1373	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	0.18114205166283148	[682]	[918,959,661,244]	1	hSpCas9	negative selection	7999703
64460227	64460250	12	+	27260156	NCIH1373	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.2651948934364461	[133]	[72,155,96,103]	2	hSpCas9	negative selection	7999704
64464400	64464423	12	+	27260156	NCIH1373	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.41078847181018036	[502]	[581,168,464,140]	-4	hSpCas9	negative selection	7999705
64474290	64474313	12	+	27260156	NCIH1373	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.6056319842092381	[239]	[100,58,164,103]	-6	hSpCas9	negative selection	8063957
64460243	64460266	12	-	27260156	NCIH1373	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.2430480361566003	[1315]	[2860,1527,1284,391]	2	hSpCas9	negative selection	8063958
64464373	64464396	12	-	27260156	NCIH1373	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.45048437297442223	[1129]	[1228,806,1031,177]	-4	hSpCas9	negative selection	8063959
64474368	64474391	12	-	27260156	PATU8902	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	0.1875731730876733	[682]	[891,1186,1053,1217]	2	hSpCas9	negative selection	8120954
64460227	64460250	12	+	27260156	PATU8902	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.010451604143941529	[133]	[254,110,67,367]	0	hSpCas9	negative selection	8120955
64464400	64464423	12	+	27260156	PATU8902	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.0975276709710845	[502]	[493,980,408,815]	-1	hSpCas9	negative selection	8120956
64474290	64474313	12	+	27260156	PATU8902	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.6917238837375181	[239]	[68,380,168,220]	-6	hSpCas9	negative selection	8185208
64460243	64460266	12	-	27260156	PATU8902	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.5243650638777886	[1315]	[2080,3284,2348,2926]	5	hSpCas9	negative selection	8185209
64464373	64464396	12	-	27260156	PATU8902	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.4879435639439008	[1129]	[989,2215,575,806]	-5	hSpCas9	negative selection	8185210
64474368	64474391	12	-	27260156	PANC1	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	0.10789636168727468	[682]	[579,554,642,711]	1	hSpCas9	negative selection	8242205
64460227	64460250	12	+	27260156	PANC1	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.12917090358451455	[133]	[73,143,118,92]	-2	hSpCas9	negative selection	8242206
64464400	64464423	12	+	27260156	PANC1	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.1614776259172248	[502]	[332,281,501,399]	-3	hSpCas9	negative selection	8242207
64474290	64474313	12	+	27260156	PANC1	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.1277897481210346	[239]	[279,192,143,140]	-2	hSpCas9	negative selection	8306459
64460243	64460266	12	-	27260156	PANC1	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.17228172053892754	[1315]	[1142,1589,1126,1278]	2	hSpCas9	negative selection	8306460
64464373	64464396	12	-	27260156	PANC1	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.015907665201418952	[1129]	[838,1172,963,975]	0	hSpCas9	negative selection	8306461
64474368	64474391	12	-	27260156	PANC0813	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.2321568717712535	[682]	[908,615,744,492]	-4	hSpCas9	negative selection	8363456
64460227	64460250	12	+	27260156	PANC0813	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.08137157617753399	[133]	[302,121,135,119]	1	hSpCas9	negative selection	8363457
64464400	64464423	12	+	27260156	PANC0813	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.2807930563051885	[502]	[355,673,568,341]	-4	hSpCas9	negative selection	8363458
64474290	64474313	12	+	27260156	PANC0813	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.2533853010504523	[239]	[241,237,347,124]	-4	hSpCas9	negative selection	8427710
64460243	64460266	12	-	27260156	PANC0813	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.0770257513500423	[1315]	[1819,1838,1567,1326]	1	hSpCas9	negative selection	8427711
64464373	64464396	12	-	27260156	PANC0813	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.31449435245698665	[1129]	[1407,760,1022,1104]	-5	hSpCas9	negative selection	8427712
64474368	64474391	12	-	27260156	RDES	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.46432534550307536	[682]	[441,450,748,681]	-7	hSpCas9	negative selection	8484707
64460227	64460250	12	+	27260156	RDES	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.19206261023294058	[133]	[95,107,201,144]	-3	hSpCas9	negative selection	8484708
64464400	64464423	12	+	27260156	RDES	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.3296017735957207	[502]	[358,428,559,516]	-5	hSpCas9	negative selection	8484709
64474290	64474313	12	+	27260156	RDES	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.6167839393767982	[239]	[108,185,227,213]	-8	hSpCas9	negative selection	8548961
64460243	64460266	12	-	27260156	RDES	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.10909074456976708	[1315]	[1467,1615,1563,1903]	1	hSpCas9	negative selection	8548962
64464373	64464396	12	-	27260156	RDES	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.5487242719174523	[1129]	[802,806,924,1040]	-7	hSpCas9	negative selection	8548963
64474368	64474391	12	-	27260156	PC3	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	0.054973134747447916	[682]	[561,562,907,867]	1	hSpCas9	negative selection	8605958
64460227	64460250	12	+	27260156	PC3	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.1979516557238017	[133]	[167,163,208,56]	4	hSpCas9	negative selection	8605959
64464400	64464423	12	+	27260156	PC3	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	0.22484297791222513	[502]	[459,447,924,638]	5	hSpCas9	negative selection	8605960
64474290	64474313	12	+	27260156	PC3	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	0.3422627745528486	[239]	[326,120,367,377]	7	hSpCas9	negative selection	8670212
64460243	64460266	12	-	27260156	PC3	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.18884474534394613	[1315]	[880,1667,2096,1696]	4	hSpCas9	negative selection	8670213
64464373	64464396	12	-	27260156	PC3	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.09111189316274193	[1129]	[715,1074,1910,1494]	2	hSpCas9	negative selection	8670214
64474368	64474391	12	-	27260156	PATU8988T	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.023963228315028395	[682]	[485,768,514,855]	0	hSpCas9	negative selection	8727209
64460227	64460250	12	+	27260156	PATU8988T	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.8444339354200054	[133]	[67,88,52,80]	-8	hSpCas9	negative selection	8727210
64464400	64464423	12	+	27260156	PATU8988T	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.19024539244119681	[502]	[623,360,432,266]	-3	hSpCas9	negative selection	8727211
64474290	64474313	12	+	27260156	PATU8988T	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.28031138279137924	[239]	[222,137,290,97]	-5	hSpCas9	negative selection	8791463
64460243	64460266	12	-	27260156	PATU8988T	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.14422874136618402	[1315]	[1172,1556,1156,1781]	2	hSpCas9	negative selection	8791464
64464373	64464396	12	-	27260156	PATU8988T	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.16834663581029474	[1129]	[831,945,1100,1005]	-3	hSpCas9	negative selection	8791465
64474368	64474391	12	-	27260156	T47D	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	0.05113772618533863	[682]	[914,690,927,771]	1	hSpCas9	negative selection	8848460
64460227	64460250	12	+	27260156	T47D	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.10433755963305869	[133]	[91,228,184,158]	2	hSpCas9	negative selection	8848461
64464400	64464423	12	+	27260156	T47D	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.24778771912067848	[502]	[576,400,510,492]	-5	hSpCas9	negative selection	8848462
64474290	64474313	12	+	27260156	T47D	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.13197714437940422	[239]	[318,203,254,246]	-3	hSpCas9	negative selection	8912714
64460243	64460266	12	-	27260156	T47D	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.05269528279389979	[1315]	[1775,1387,1642,1569]	1	hSpCas9	negative selection	8912715
64464373	64464396	12	-	27260156	T47D	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.10789248281381147	[1129]	[1263,1233,1223,1160]	-2	hSpCas9	negative selection	8912716
64474368	64474391	12	-	27260156	SU8686	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	0.13910633668922567	[682]	[655,745,705,903]	2	hSpCas9	negative selection	8969711
64460227	64460250	12	+	27260156	SU8686	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.23006189408851996	[133]	[84,93,167,317]	4	hSpCas9	negative selection	8969712
64464400	64464423	12	+	27260156	SU8686	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	0.06721312912268611	[502]	[413,480,376,886]	1	hSpCas9	negative selection	8969713
64474290	64474313	12	+	27260156	SU8686	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.19669211065198122	[239]	[152,142,252,312]	-3	hSpCas9	negative selection	9033965
64460243	64460266	12	-	27260156	SU8686	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.16251385669923435	[1315]	[1463,1083,1531,1866]	2	hSpCas9	negative selection	9033966
64464373	64464396	12	-	27260156	SU8686	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.2520404982000952	[1129]	[878,768,940,1245]	-4	hSpCas9	negative selection	9033967
64474368	64474391	12	-	27260156	SKES1	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.23093077231978565	[682]	[686,770,451,459]	-5	hSpCas9	negative selection	9090962
64460227	64460250	12	+	27260156	SKES1	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	-0.27033431052167645	[133]	[118,130,115,82]	-5	hSpCas9	negative selection	9090963
64464400	64464423	12	+	27260156	SKES1	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.3392104774373795	[502]	[399,364,378,430]	-6	hSpCas9	negative selection	9090964
64474290	64474313	12	+	27260156	SKES1	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.6555394146214808	[239]	[191,221,142,72]	-8	hSpCas9	negative selection	9155216
64460243	64460266	12	-	27260156	SKES1	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.0570477885949896	[1315]	[1566,1519,1305,1130]	1	hSpCas9	negative selection	9155217
64464373	64464396	12	-	27260156	SKES1	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.39239435850999405	[1129]	[792,1060,699,885]	-7	hSpCas9	negative selection	9155218
64474368	64474391	12	-	27260156	TOV112D	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.005515516148001609	[682]	[562,781,805,590]	0	hSpCas9	negative selection	9212213
64460227	64460250	12	+	27260156	TOV112D	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.09322481113359626	[133]	[143,119,166,135]	1	hSpCas9	negative selection	9212214
64464400	64464423	12	+	27260156	TOV112D	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.20759673972696369	[502]	[403,561,458,349]	-4	hSpCas9	negative selection	9212215
64474290	64474313	12	+	27260156	TOV112D	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.8102779031298928	[239]	[155,169,138,93]	-9	hSpCas9	negative selection	9276467
64460243	64460266	12	-	27260156	TOV112D	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.25265640155581814	[1315]	[1391,2010,1540,1431]	5	hSpCas9	negative selection	9276468
64464373	64464396	12	-	27260156	TOV112D	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.2362706121748095	[1129]	[868,1117,1014,872]	-4	hSpCas9	negative selection	9276469
64474368	64474391	12	-	27260156	TC71	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	-0.16069705038075988	[682]	[495,776,644,708]	-4	hSpCas9	negative selection	9333464
64460227	64460250	12	+	27260156	TC71	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.248815154319052	[133]	[156,145,175,205]	6	hSpCas9	negative selection	9333465
64464400	64464423	12	+	27260156	TC71	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.216127728174123	[502]	[554,496,427,369]	-5	hSpCas9	negative selection	9333466
64474290	64474313	12	+	27260156	TC71	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.21779687324110353	[239]	[194,188,263,236]	-5	hSpCas9	negative selection	9397718
64460243	64460266	12	-	27260156	TC71	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.2212297551995661	[1315]	[1631,1584,1710,1647]	5	hSpCas9	negative selection	9397719
64464373	64464396	12	-	27260156	TC71	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.059392307407545974	[1129]	[1147,1008,1072,1439]	-1	hSpCas9	negative selection	9397720
64474368	64474391	12	-	27260156	TC32	viability	ATCACTTCTTTATTCCTACGAGG	TBK1	ENSG00000183735	0.10657502128827778	[682]	[491,574,952,825]	2	hSpCas9	negative selection	9454715
64460227	64460250	12	+	27260156	TC32	viability	CATAAGCTTCCTTCGTCCAGTGG	TBK1	ENSG00000183735	0.24008327039314192	[133]	[147,160,88,172]	4	hSpCas9	negative selection	9454716
64464400	64464423	12	+	27260156	TC32	viability	GAAGAACCTTCTAATGCCTATGG	TBK1	ENSG00000183735	-0.02623786385931416	[502]	[387,360,712,458]	0	hSpCas9	negative selection	9454717
64474290	64474313	12	+	27260156	TC32	viability	ACAGTTGATCTTTGGAGCATTGG	TBK1	ENSG00000183735	-0.5628822351984202	[239]	[129,145,129,198]	-8	hSpCas9	negative selection	9518969
64460243	64460266	12	-	27260156	TC32	viability	TCTCTCATTTGAACATCCACTGG	TBK1	ENSG00000183735	0.011315078202622564	[1315]	[1212,789,1664,1510]	0	hSpCas9	negative selection	9518970
64464373	64464396	12	-	27260156	TC32	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	-0.31167573719796215	[1129]	[782,706,1062,921]	-5	hSpCas9	negative selection	9518971
64460236	64460259	12	-	27869803	HPAFII	viability after 27 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.5116965514111631	[309]	[227,235,NaN]	4	hSpCas9	negative selection	9548113
64474356	64474379	12	-	27869803	HPAFII	viability after 27 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.6151279055146386	[337]	[377,183,NaN]	5	hSpCas9	negative selection	9548114
64480070	64480093	12	+	27869803	HPAFII	viability after 27 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.46699973568491365	[156]	[196,44,NaN]	4	hSpCas9	negative selection	9548115
64484379	64484402	12	+	27869803	HPAFII	viability after 27 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.3090609226990242	[517]	[365,97,NaN]	-2	hSpCas9	negative selection	9548116
64485459	64485482	12	-	27869803	HPAFII	viability after 27 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.34725476114563325	[352]	[234,236,NaN]	2	hSpCas9	negative selection	9548117
64490053	64490076	12	+	27869803	HPAFII	viability after 27 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.6342521715068977	[134]	[36,52,NaN]	-4	hSpCas9	negative selection	9548118
64460236	64460259	12	-	27869803	HPAFII	viability after 15 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.09858876214130419	[309]	[492,271,NaN]	1	hSpCas9	negative selection	9630562
64474356	64474379	12	-	27869803	HPAFII	viability after 15 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.49009434486909104	[337]	[791,334,NaN]	5	hSpCas9	negative selection	9630563
64480070	64480093	12	+	27869803	HPAFII	viability after 15 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	-0.3024060548693036	[156]	[224,81,NaN]	-3	hSpCas9	negative selection	9630564
64484379	64484402	12	+	27869803	HPAFII	viability after 15 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.11041509546167028	[517]	[786,346,NaN]	-1	hSpCas9	negative selection	9630565
64485459	64485482	12	-	27869803	HPAFII	viability after 15 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	-0.3877653660773337	[352]	[268,302,NaN]	-4	hSpCas9	negative selection	9630566
64490053	64490076	12	+	27869803	HPAFII	viability after 15 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.6590299249564734	[134]	[110,79,NaN]	-6	hSpCas9	negative selection	9630567
64460236	64460259	12	-	27869803	ASPC1	viability after 36 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.6236458384461264	[703]	[415,547,213]	6	hSpCas9	negative selection	9713011
64474356	64474379	12	-	27869803	ASPC1	viability after 36 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.6606972385807717	[889]	[491,187,725]	6	hSpCas9	negative selection	9713012
64480070	64480093	12	+	27869803	ASPC1	viability after 36 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.1198446117905273	[337]	[78,299,24]	1	hSpCas9	negative selection	9713013
64484379	64484402	12	+	27869803	ASPC1	viability after 36 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.1675221358897927	[1538]	[573,470,411]	-2	hSpCas9	negative selection	9713014
64485459	64485482	12	-	27869803	ASPC1	viability after 36 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.06665205253916395	[986]	[372,465,264]	0	hSpCas9	negative selection	9713015
64490053	64490076	12	+	27869803	ASPC1	viability after 36 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.5430096933168175	[241]	[194,57,122]	5	hSpCas9	negative selection	9713016
64460236	64460259	12	-	27869803	PATU8988S	viability after 35 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.039685302107993065	[596]	[197,269,NaN]	0	hSpCas9	negative selection	9795460
64474356	64474379	12	-	27869803	PATU8988S	viability after 35 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.4761191566606096	[728]	[243,177,NaN]	-5	hSpCas9	negative selection	9795461
64480070	64480093	12	+	27869803	PATU8988S	viability after 35 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.079090478937491	[300]	[153,101,NaN]	0	hSpCas9	negative selection	9795462
64484379	64484402	12	+	27869803	PATU8988S	viability after 35 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.006610700959859717	[1028]	[427,396,NaN]	0	hSpCas9	negative selection	9795463
64485459	64485482	12	-	27869803	PATU8988S	viability after 35 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.9320562179485592	[598]	[371,548,NaN]	8	hSpCas9	negative selection	9795464
64490053	64490076	12	+	27869803	PATU8988S	viability after 35 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	1.0247088989939186	[176]	[160,128,NaN]	9	hSpCas9	negative selection	9795465
64460236	64460259	12	-	27869803	PATU8988S	viability after 31 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	-0.10099881585424818	[596]	[195,254,NaN]	-1	hSpCas9	negative selection	9877909
64474356	64474379	12	-	27869803	PATU8988S	viability after 31 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	-0.6064785838028468	[728]	[193,186,NaN]	-6	hSpCas9	negative selection	9877910
64480070	64480093	12	+	27869803	PATU8988S	viability after 31 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	-0.37356229929248186	[300]	[100,81,NaN]	-4	hSpCas9	negative selection	9877911
64484379	64484402	12	+	27869803	PATU8988S	viability after 31 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	-0.10502511618766142	[1028]	[278,511,NaN]	-1	hSpCas9	negative selection	9877912
64485459	64485482	12	-	27869803	PATU8988S	viability after 31 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.9261206188964415	[598]	[298,650,NaN]	9	hSpCas9	negative selection	9877913
64490053	64490076	12	+	27869803	PATU8988S	viability after 31 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.761903191640621	[176]	[120,117,NaN]	8	hSpCas9	negative selection	9877914
64460236	64460259	12	-	27869803	HPAFII	viability after 35 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.4530957043603951	[309]	[132,306,NaN]	3	hSpCas9	negative selection	9960358
64474356	64474379	12	-	27869803	HPAFII	viability after 35 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	0.8291741451436048	[337]	[319,285,NaN]	5	hSpCas9	negative selection	9960359
64480070	64480093	12	+	27869803	HPAFII	viability after 35 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.6256178193158193	[156]	[203,30,NaN]	4	hSpCas9	negative selection	9960360
64484379	64484402	12	+	27869803	HPAFII	viability after 35 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.09409479871764104	[517]	[452,84,NaN]	0	hSpCas9	negative selection	9960361
64485459	64485482	12	-	27869803	HPAFII	viability after 35 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.002252524502894482	[352]	[146,214,NaN]	0	hSpCas9	negative selection	9960362
64490053	64490076	12	+	27869803	HPAFII	viability after 35 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.3090193657203216	[134]	[33,78,NaN]	-2	hSpCas9	negative selection	9960363
64460236	64460259	12	-	27869803	HPAFII	viability after 31 days	TTTGAACATCCACTGGACGAAGG	TBK1	ENSG00000183735	0.1633082469950577	[309]	[190,198,NaN]	1	hSpCas9	negative selection	10042807
64474356	64474379	12	-	27869803	HPAFII	viability after 31 days	TTCCTACGAGGCCCTTCAAAGGG	TBK1	ENSG00000183735	1.0392935206096099	[337]	[408,368,NaN]	7	hSpCas9	negative selection	10042808
64480070	64480093	12	+	27869803	HPAFII	viability after 31 days	AATGGACCAATTGACTGGAGTGG	TBK1	ENSG00000183735	0.3901425661610323	[156]	[192,30,NaN]	3	hSpCas9	negative selection	10042809
64484379	64484402	12	+	27869803	HPAFII	viability after 31 days	CGACGCTTAGTCTTAGAACCTGG	TBK1	ENSG00000183735	0.019875952832951516	[517]	[489,81,NaN]	0	hSpCas9	negative selection	10042810
64485459	64485482	12	-	27869803	HPAFII	viability after 31 days	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	-0.30487984657894907	[352]	[123,199,NaN]	-2	hSpCas9	negative selection	10042811
64490053	64490076	12	+	27869803	HPAFII	viability after 31 days	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.0010893364722004417	[134]	[82,67,NaN]	0	hSpCas9	negative selection	10042812
64481862	64481885	12	-	28162770	P31FUJ	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	-0.9946424672196141	[116]	[68]	-6	hSpCas9	negative selection	10247920
64495561	64495584	12	+	28162770	P31FUJ	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	0.4135608409709209	[229]	[359]	4	hSpCas9	negative selection	10247921
64485459	64485482	12	-	28162770	P31FUJ	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.553794157476428	[319]	[551]	6	hSpCas9	negative selection	10247922
64490053	64490076	12	+	28162770	P31FUJ	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.6511007306627501	[96]	[178]	7	hSpCas9	negative selection	10247923
64464373	64464396	12	-	28162770	P31FUJ	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.5259273640434841	[749]	[1268]	6	hSpCas9	negative selection	10247924
64480052	64480075	12	+	28162770	P31FUJ	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	0.1297678749703295	[125]	[161]	1	hSpCas9	negative selection	10247925
64495547	64495570	12	+	28162770	P31FUJ	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	0.8014676976703676	[207]	[425]	8	hSpCas9	negative selection	10247926
64481886	64481909	12	+	28162770	P31FUJ	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.08246216019197297	[216]	[269]	0	hSpCas9	negative selection	10247927
64485475	64485498	12	-	28162770	P31FUJ	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	0.5591492490281288	[416]	[721]	6	hSpCas9	negative selection	10247928
64495528	64495551	12	+	28162770	P31FUJ	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.4436764426225914	[452]	[723]	5	hSpCas9	negative selection	10247929
64481862	64481885	12	-	28162770	TF1	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	NaN	[NaN]	[19]	1	hSpCas9	negative selection	10417286
64495561	64495584	12	+	28162770	TF1	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	NaN	[NaN]	[177]	1	hSpCas9	negative selection	10417287
64485459	64485482	12	-	28162770	TF1	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	NaN	[NaN]	[220]	1	hSpCas9	negative selection	10417288
64490053	64490076	12	+	28162770	TF1	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	NaN	[NaN]	[109]	1	hSpCas9	negative selection	10417289
64464373	64464396	12	-	28162770	TF1	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	NaN	[NaN]	[544]	1	hSpCas9	negative selection	10417290
64480052	64480075	12	+	28162770	TF1	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	NaN	[NaN]	[123]	1	hSpCas9	negative selection	10417291
64495547	64495570	12	+	28162770	TF1	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	NaN	[NaN]	[266]	1	hSpCas9	negative selection	10417292
64481886	64481909	12	+	28162770	TF1	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	NaN	[NaN]	[170]	1	hSpCas9	negative selection	10417293
64485475	64485498	12	-	28162770	TF1	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	NaN	[NaN]	[427]	1	hSpCas9	negative selection	10417294
64495528	64495551	12	+	28162770	TF1	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	NaN	[NaN]	[379]	1	hSpCas9	negative selection	10417295
64481862	64481885	12	-	28162770	SKM1	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	0.26046046216996765	[33]	[71]	2	hSpCas9	negative selection	10586652
64495561	64495584	12	+	28162770	SKM1	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	-0.12762798058026728	[54]	[88]	-1	hSpCas9	negative selection	10586653
64485459	64485482	12	-	28162770	SKM1	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.499926396865357	[95]	[239]	5	hSpCas9	negative selection	10586654
64490053	64490076	12	+	28162770	SKM1	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.9853532240355987	[25]	[90]	8	hSpCas9	negative selection	10586655
64464373	64464396	12	-	28162770	SKM1	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.4469333092514727	[182]	[440]	4	hSpCas9	negative selection	10586656
64480052	64480075	12	+	28162770	SKM1	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	-0.8615300622086429	[36]	[35]	-6	hSpCas9	negative selection	10586657
64495547	64495570	12	+	28162770	SKM1	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	0.025995208532944458	[64]	[116]	0	hSpCas9	negative selection	10586658
64481886	64481909	12	+	28162770	SKM1	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.7851565488133468	[42]	[130]	7	hSpCas9	negative selection	10586659
64485475	64485498	12	-	28162770	SKM1	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	0.8770672883856723	[80]	[262]	8	hSpCas9	negative selection	10586660
64495528	64495551	12	+	28162770	SKM1	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.04049477822805958	[87]	[159]	0	hSpCas9	negative selection	10586661
64481862	64481885	12	-	28162770	SKM1	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	0.26046046216996765	[33]	[71]	2	hSpCas9	negative selection	10756018
64495561	64495584	12	+	28162770	SKM1	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	-0.12762798058026728	[54]	[88]	-1	hSpCas9	negative selection	10756019
64485459	64485482	12	-	28162770	SKM1	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.499926396865357	[95]	[239]	5	hSpCas9	negative selection	10756020
64490053	64490076	12	+	28162770	SKM1	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.9853532240355987	[25]	[90]	8	hSpCas9	negative selection	10756021
64464373	64464396	12	-	28162770	SKM1	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.4469333092514727	[182]	[440]	4	hSpCas9	negative selection	10756022
64480052	64480075	12	+	28162770	SKM1	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	-0.8615300622086429	[36]	[35]	-6	hSpCas9	negative selection	10756023
64495547	64495570	12	+	28162770	SKM1	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	0.025995208532944458	[64]	[116]	0	hSpCas9	negative selection	10756024
64481886	64481909	12	+	28162770	SKM1	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.7851565488133468	[42]	[130]	7	hSpCas9	negative selection	10756025
64485475	64485498	12	-	28162770	SKM1	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	0.8770672883856723	[80]	[262]	8	hSpCas9	negative selection	10756026
64495528	64495551	12	+	28162770	SKM1	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.04049477822805958	[87]	[159]	0	hSpCas9	negative selection	10756027
64481862	64481885	12	-	28162770	PL21	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	0.2968156339009941	[100]	[53]	2	hSpCas9	negative selection	10925384
64495561	64495584	12	+	28162770	PL21	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	0.07460873240546118	[167]	[76]	0	hSpCas9	negative selection	10925385
64485459	64485482	12	-	28162770	PL21	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.04813652104427013	[319]	[143]	0	hSpCas9	negative selection	10925386
64490053	64490076	12	+	28162770	PL21	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-1.4321286010101926	[92]	[14]	-7	hSpCas9	negative selection	10925387
64464373	64464396	12	-	28162770	PL21	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.3551142744656608	[678]	[377]	3	hSpCas9	negative selection	10925388
64480052	64480075	12	+	28162770	PL21	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	-0.22307181623522365	[117]	[43]	-2	hSpCas9	negative selection	10925389
64495547	64495570	12	+	28162770	PL21	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	1.0312106055207317	[180]	[160]	8	hSpCas9	negative selection	10925390
64481886	64481909	12	+	28162770	PL21	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.5110687104274255	[157]	[97]	4	hSpCas9	negative selection	10925391
64485475	64485498	12	-	28162770	PL21	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	1.1139829707396056	[275]	[259]	8	hSpCas9	negative selection	10925392
64495528	64495551	12	+	28162770	PL21	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	-0.27790768231532414	[350]	[125]	-2	hSpCas9	negative selection	10925393
64481862	64481885	12	-	28162770	P31FUJ	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	-0.9946424672196141	[116]	[68]	-6	hSpCas9	negative selection	11094750
64495561	64495584	12	+	28162770	P31FUJ	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	0.4135608409709209	[229]	[359]	4	hSpCas9	negative selection	11094751
64485459	64485482	12	-	28162770	P31FUJ	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.553794157476428	[319]	[551]	6	hSpCas9	negative selection	11094752
64490053	64490076	12	+	28162770	P31FUJ	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.6511007306627501	[96]	[178]	7	hSpCas9	negative selection	11094753
64464373	64464396	12	-	28162770	P31FUJ	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.5259273640434841	[749]	[1268]	6	hSpCas9	negative selection	11094754
64480052	64480075	12	+	28162770	P31FUJ	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	0.1297678749703295	[125]	[161]	1	hSpCas9	negative selection	11094755
64495547	64495570	12	+	28162770	P31FUJ	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	0.8014676976703676	[207]	[425]	8	hSpCas9	negative selection	11094756
64481886	64481909	12	+	28162770	P31FUJ	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.08246216019197297	[216]	[269]	0	hSpCas9	negative selection	11094757
64485475	64485498	12	-	28162770	P31FUJ	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	0.5591492490281288	[416]	[721]	6	hSpCas9	negative selection	11094758
64495528	64495551	12	+	28162770	P31FUJ	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.4436764426225914	[452]	[723]	5	hSpCas9	negative selection	11094759
64481862	64481885	12	-	28162770	OCIAML5	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	2.420951923542419	[23]	[231]	9	hSpCas9	negative selection	11264116
64495561	64495584	12	+	28162770	OCIAML5	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	0.5500318727073485	[153]	[406]	5	hSpCas9	negative selection	11264117
64485459	64485482	12	-	28162770	OCIAML5	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.6132256991945428	[200]	[554]	5	hSpCas9	negative selection	11264118
64490053	64490076	12	+	28162770	OCIAML5	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-2.009607847850477	[115]	[51]	-8	hSpCas9	negative selection	11264119
64464373	64464396	12	-	28162770	OCIAML5	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.4237539899256402	[336]	[815]	3	hSpCas9	negative selection	11264120
64480052	64480075	12	+	28162770	OCIAML5	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	0.19977236065562098	[40]	[84]	1	hSpCas9	negative selection	11264121
64495547	64495570	12	+	28162770	OCIAML5	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	0.7278249403097372	[94]	[283]	6	hSpCas9	negative selection	11264122
64481886	64481909	12	+	28162770	OCIAML5	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.8359894228212625	[71]	[231]	7	hSpCas9	negative selection	11264123
64485475	64485498	12	-	28162770	OCIAML5	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	0.09134990076963567	[337]	[649]	0	hSpCas9	negative selection	11264124
64495528	64495551	12	+	28162770	OCIAML5	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.23853597791690961	[215]	[459]	2	hSpCas9	negative selection	11264125
64481862	64481885	12	-	28162770	EOL1	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	-0.4012223896112219	[187]	[74]	-3	hSpCas9	negative selection	11433482
64495561	64495584	12	+	28162770	EOL1	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	0.4544689087337287	[186]	[134]	4	hSpCas9	negative selection	11433483
64485459	64485482	12	-	28162770	EOL1	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.7651359968108981	[563]	[504]	6	hSpCas9	negative selection	11433484
64490053	64490076	12	+	28162770	EOL1	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.24122014100640166	[219]	[136]	2	hSpCas9	negative selection	11433485
64464373	64464396	12	-	28162770	EOL1	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.2686493640384333	[1187]	[753]	2	hSpCas9	negative selection	11433486
64480052	64480075	12	+	28162770	EOL1	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	0.3822296082578718	[149]	[102]	3	hSpCas9	negative selection	11433487
64495547	64495570	12	+	28162770	EOL1	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	1.1058775362850963	[223]	[253]	8	hSpCas9	negative selection	11433488
64481886	64481909	12	+	28162770	EOL1	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	-0.390954054157395	[223]	[89]	-3	hSpCas9	negative selection	11433489
64485475	64485498	12	-	28162770	EOL1	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	-0.2691333531243859	[397]	[173]	-2	hSpCas9	negative selection	11433490
64495528	64495551	12	+	28162770	EOL1	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.15070211170318143	[382]	[223]	1	hSpCas9	negative selection	11433491
64481862	64481885	12	-	28162770	MOLM13	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	0.7957749317283407	[144]	[181]	6	hSpCas9	negative selection	11602848
64495561	64495584	12	+	28162770	MOLM13	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	-0.054717041830927425	[282]	[196]	0	hSpCas9	negative selection	11602849
64485459	64485482	12	-	28162770	MOLM13	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.5424113248108899	[414]	[436]	4	hSpCas9	negative selection	11602850
64490053	64490076	12	+	28162770	MOLM13	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.016326006240621083	[159]	[116]	0	hSpCas9	negative selection	11602851
64464373	64464396	12	-	28162770	MOLM13	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.5878084345109853	[922]	[1002]	4	hSpCas9	negative selection	11602852
64480052	64480075	12	+	28162770	MOLM13	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	-0.5614545800375655	[148]	[72]	-3	hSpCas9	negative selection	11602853
64495547	64495570	12	+	28162770	MOLM13	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	-0.8540387133427836	[244]	[97]	-5	hSpCas9	negative selection	11602854
64481886	64481909	12	+	28162770	MOLM13	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	-0.02450700044050466	[248]	[176]	0	hSpCas9	negative selection	11602855
64485475	64485498	12	-	28162770	MOLM13	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	-0.2699804401917415	[531]	[318]	-2	hSpCas9	negative selection	11602856
64495528	64495551	12	+	28162770	MOLM13	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	-0.6968071050959228	[481]	[214]	-4	hSpCas9	negative selection	11602857
64481862	64481885	12	-	28162770	HEL	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	-0.05163488544138112	[177]	[109]	0	hSpCas9	negative selection	11772214
64495561	64495584	12	+	28162770	HEL	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	-0.045675017333739826	[223]	[138]	0	hSpCas9	negative selection	11772215
64485459	64485482	12	-	28162770	HEL	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.7536120494855523	[337]	[364]	6	hSpCas9	negative selection	11772216
64490053	64490076	12	+	28162770	HEL	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.9228583438538681	[147]	[49]	-5	hSpCas9	negative selection	11772217
64464373	64464396	12	-	28162770	HEL	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.5559478971694696	[804]	[757]	5	hSpCas9	negative selection	11772218
64480052	64480075	12	+	28162770	HEL	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	0.45672684639040817	[123]	[108]	4	hSpCas9	negative selection	11772219
64495547	64495570	12	+	28162770	HEL	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	-0.7409654604736953	[166]	[63]	-5	hSpCas9	negative selection	11772220
64481886	64481909	12	+	28162770	HEL	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.2365794840679658	[215]	[162]	2	hSpCas9	negative selection	11772221
64485475	64485498	12	-	28162770	HEL	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	-0.7661933046292997	[392]	[147]	-5	hSpCas9	negative selection	11772222
64495528	64495551	12	+	28162770	HEL	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.130333495853309	[474]	[332]	1	hSpCas9	negative selection	11772223
64481862	64481885	12	-	28162770	MV411	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	0.3968151748210021	[109]	[121]	3	hSpCas9	negative selection	11941580
64495561	64495584	12	+	28162770	MV411	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	0.5905114545416862	[148]	[188]	5	hSpCas9	negative selection	11941581
64485459	64485482	12	-	28162770	MV411	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.2643774132044876	[253]	[256]	2	hSpCas9	negative selection	11941582
64490053	64490076	12	+	28162770	MV411	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	0.9844031449489814	[80]	[134]	8	hSpCas9	negative selection	11941583
64464373	64464396	12	-	28162770	MV411	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.7604502096249166	[554]	[791]	7	hSpCas9	negative selection	11941584
64480052	64480075	12	+	28162770	MV411	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	1.3767205677277419	[95]	[209]	9	hSpCas9	negative selection	11941585
64495547	64495570	12	+	28162770	MV411	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	0.36685271772754596	[196]	[213]	3	hSpCas9	negative selection	11941586
64481886	64481909	12	+	28162770	MV411	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.5483915165763962	[193]	[238]	5	hSpCas9	negative selection	11941587
64485475	64485498	12	-	28162770	MV411	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	0.29502700930103565	[327]	[338]	2	hSpCas9	negative selection	11941588
64495528	64495551	12	+	28162770	MV411	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.8795458311298723	[290]	[450]	7	hSpCas9	negative selection	11941589
64481862	64481885	12	-	28162770	MONOMAC1	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	-0.47601279676236913	[90]	[74]	-4	hSpCas9	negative selection	12110946
64495561	64495584	12	+	28162770	MONOMAC1	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	0.3249158561358021	[77]	[111]	3	hSpCas9	negative selection	12110947
64485459	64485482	12	-	28162770	MONOMAC1	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	1.1360072800219827	[180]	[455]	8	hSpCas9	negative selection	12110948
64490053	64490076	12	+	28162770	MONOMAC1	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.8751087521721911	[71]	[44]	-6	hSpCas9	negative selection	12110949
64464373	64464396	12	-	28162770	MONOMAC1	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.0850267869498691	[476]	[579]	0	hSpCas9	negative selection	12110950
64480052	64480075	12	+	28162770	MONOMAC1	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	-0.9340024412257598	[64]	[38]	-6	hSpCas9	negative selection	12110951
64495547	64495570	12	+	28162770	MONOMAC1	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	1.3226796290461642	[97]	[280]	9	hSpCas9	negative selection	12110952
64481886	64481909	12	+	28162770	MONOMAC1	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	-0.37848371839708556	[109]	[96]	-3	hSpCas9	negative selection	12110953
64485475	64485498	12	-	28162770	MONOMAC1	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	0.33408750203405224	[181]	[262]	3	hSpCas9	negative selection	12110954
64495528	64495551	12	+	28162770	MONOMAC1	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	-0.4789043652518401	[292]	[240]	-4	hSpCas9	negative selection	12110955
64481862	64481885	12	-	28162770	OCIAML2	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	0.022909647715400383	[18]	[106]	0	hSpCas9	negative selection	12280312
64495561	64495584	12	+	28162770	OCIAML2	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	1.5164311190503406	[34]	[554]	9	hSpCas9	negative selection	12280313
64485459	64485482	12	-	28162770	OCIAML2	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.8184668771778287	[39]	[390]	7	hSpCas9	negative selection	12280314
64490053	64490076	12	+	28162770	OCIAML2	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.6904110331220711	[22]	[78]	-5	hSpCas9	negative selection	12280315
64464373	64464396	12	-	28162770	OCIAML2	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.4014953522056808	[111]	[819]	4	hSpCas9	negative selection	12280316
64480052	64480075	12	+	28162770	OCIAML2	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	1.0296355109037136	[18]	[214]	8	hSpCas9	negative selection	12280317
64495547	64495570	12	+	28162770	OCIAML2	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	0.24557720875724756	[34]	[229]	2	hSpCas9	negative selection	12280318
64481886	64481909	12	+	28162770	OCIAML2	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.5902524169048611	[28]	[241]	6	hSpCas9	negative selection	12280319
64485475	64485498	12	-	28162770	OCIAML2	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	-0.13911568152560072	[59]	[301]	-1	hSpCas9	negative selection	12280320
64495528	64495551	12	+	28162770	OCIAML2	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.5981484527432513	[63]	[536]	6	hSpCas9	negative selection	12280321
64481862	64481885	12	-	28162770	OCIAML3	viability	AAGGATGTTTGCAAGAACAGGGG	TBK1	ENSG00000183735	1.0662429877012303	[27]	[176]	8	hSpCas9	negative selection	12449678
64495561	64495584	12	+	28162770	OCIAML3	viability	GACGCATGGGCACATCAAGAAGG	TBK1	ENSG00000183735	0.4913838509064813	[40]	[173]	4	hSpCas9	negative selection	12449679
64485459	64485482	12	-	28162770	OCIAML3	viability	AACGTGGATGTACTTTAGGGAGG	TBK1	ENSG00000183735	0.1770511525104509	[91]	[313]	1	hSpCas9	negative selection	12449680
64490053	64490076	12	+	28162770	OCIAML3	viability	GATGAAGATCAACCTGGAAGCGG	TBK1	ENSG00000183735	-0.029223021540637495	[23]	[70]	0	hSpCas9	negative selection	12449681
64464373	64464396	12	-	28162770	OCIAML3	viability	ACAGTGTATAAACTCCCACATGG	TBK1	ENSG00000183735	0.1720508653623698	[161]	[550]	1	hSpCas9	negative selection	12449682
64480052	64480075	12	+	28162770	OCIAML3	viability	GGAGTACAGAAAGCAGAAAATGG	TBK1	ENSG00000183735	-0.026967047600269356	[26]	[79]	0	hSpCas9	negative selection	12449683
64495547	64495570	12	+	28162770	OCIAML3	viability	GTGGATCACTGGCAGACGCATGG	TBK1	ENSG00000183735	1.031827141812521	[57]	[357]	8	hSpCas9	negative selection	12449684
64481886	64481909	12	+	28162770	OCIAML3	viability	AAGCAGATCAGGAAAAGTGTTGG	TBK1	ENSG00000183735	0.6848517326713133	[33]	[164]	6	hSpCas9	negative selection	12449685
64485475	64485498	12	-	28162770	OCIAML3	viability	TCCCCGTCTAAATCATAACGTGG	TBK1	ENSG00000183735	0.7335123028075531	[102]	[516]	6	hSpCas9	negative selection	12449686
64495528	64495551	12	+	28162770	OCIAML3	viability	GACAGCAGATTATCTCCAGGTGG	TBK1	ENSG00000183735	0.5653921812554381	[106]	[477]	5	hSpCas9	negative selection	12449687