Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 55775
• Symbol: TDP1
• Description: tyrosyl-DNA phosphodiesterase 1

DataSource: http://genomecrispr.dkfz.de/#!/results/TDP1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
89963227	89963250	14	+	26472758	Jiyoye	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	6.2651563766334455	[0]	[57]	9	hSpCas9	negative selection	163569
89980610	89980633	14	+	26472758	Jiyoye	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	0.4071753815058736	[19]	[19]	3	hSpCas9	negative selection	163570
89963543	89963566	14	+	26472758	Jiyoye	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	0.9153222851761986	[89]	[127]	6	hSpCas9	negative selection	163571
89980570	89980593	14	-	26472758	Jiyoye	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-1.251316154637248	[160]	[50]	-7	hSpCas9	negative selection	163572
89989027	89989050	14	+	26472758	Jiyoye	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	-0.2679044139115998	[288]	[180]	-2	hSpCas9	negative selection	163573
89993400	89993423	14	-	26472758	Jiyoye	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	-1.081760231441507	[246]	[87]	-6	hSpCas9	negative selection	163574
90019376	90019399	14	-	26472758	Jiyoye	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	-0.5816840608889261	[128]	[64]	-4	hSpCas9	negative selection	163575
89963342	89963365	14	+	26472758	Jiyoye	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	0.13621405990045077	[145]	[120]	1	hSpCas9	negative selection	163576
89963663	89963686	14	-	26472758	Jiyoye	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	0.34793617813119737	[173]	[166]	2	hSpCas9	negative selection	163577
89980597	89980620	14	-	26472758	Jiyoye	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	-0.5693656456701377	[121]	[61]	-4	hSpCas9	negative selection	163578
89963227	89963250	14	+	26472758	KBM7	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	1.0727062054779313	[282,165]	[156,270]	9	hSpCas9	negative selection	354687
89980610	89980633	14	+	26472758	KBM7	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	0.529699576673138	[168,143]	[60,145]	6	hSpCas9	negative selection	354688
89963543	89963566	14	+	26472758	KBM7	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	0.16503447842356997	[732,381]	[278,291]	1	hSpCas9	negative selection	354689
89980570	89980593	14	-	26472758	KBM7	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.8531496458961857	[248,164]	[181,164]	8	hSpCas9	negative selection	354690
89989027	89989050	14	+	26472758	KBM7	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	0.014084091033580104	[818,648]	[542,169]	0	hSpCas9	negative selection	354691
89993400	89993423	14	-	26472758	KBM7	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	0.7005715734201583	[631,651]	[696,311]	7	hSpCas9	negative selection	354692
90019376	90019399	14	-	26472758	KBM7	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	0.35870094078630355	[246,289]	[182,146]	4	hSpCas9	negative selection	354693
89963342	89963365	14	+	26472758	KBM7	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	0.1755546722665018	[610,388]	[264,256]	1	hSpCas9	negative selection	354694
89963663	89963686	14	-	26472758	KBM7	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	0.10983698389094387	[1123,1354]	[619,653]	1	hSpCas9	negative selection	354695
89980597	89980620	14	-	26472758	KBM7	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	1.01381932809203	[349,300]	[323,293]	9	hSpCas9	negative selection	354696
89963227	89963250	14	+	26472758	Raji	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	0.3444227326744488	[111]	[32]	3	hSpCas9	negative selection	545805
89980610	89980633	14	+	26472758	Raji	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	-0.018147346710259082	[47]	[10]	0	hSpCas9	negative selection	545806
89963543	89963566	14	+	26472758	Raji	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	0.3118540487127851	[242]	[69]	3	hSpCas9	negative selection	545807
89980570	89980593	14	-	26472758	Raji	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.046501293226577034	[120]	[28]	0	hSpCas9	negative selection	545808
89989027	89989050	14	+	26472758	Raji	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	0.7400124697250701	[257]	[99]	7	hSpCas9	negative selection	545809
89993400	89993423	14	-	26472758	Raji	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	0.7720349247239155	[269]	[106]	7	hSpCas9	negative selection	545810
90019376	90019399	14	-	26472758	Raji	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	0.0986133257458674	[164]	[40]	0	hSpCas9	negative selection	545811
89963342	89963365	14	+	26472758	Raji	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	-0.2593987952980232	[293]	[56]	-2	hSpCas9	negative selection	545812
89963663	89963686	14	-	26472758	Raji	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	-0.46293218938315517	[587]	[98]	-4	hSpCas9	negative selection	545813
89980597	89980620	14	-	26472758	Raji	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	0.41932754168833986	[202]	[62]	4	hSpCas9	negative selection	545814
89963227	89963250	14	+	26472758	K562	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	-0.25515228182406446	[204]	[144]	-2	hSpCas9	negative selection	736923
89980610	89980633	14	+	26472758	K562	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	1.252154376446052	[92]	[186]	9	hSpCas9	negative selection	736924
89963543	89963566	14	+	26472758	K562	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	0.9574090489823126	[448]	[735]	7	hSpCas9	negative selection	736925
89980570	89980593	14	-	26472758	K562	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.9709353726016224	[193]	[320]	7	hSpCas9	negative selection	736926
89989027	89989050	14	+	26472758	K562	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	0.47001121325220696	[578]	[676]	4	hSpCas9	negative selection	736927
89993400	89993423	14	-	26472758	K562	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	0.09082237614572952	[603]	[542]	0	hSpCas9	negative selection	736928
90019376	90019399	14	-	26472758	K562	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	1.354043218840945	[265]	[573]	9	hSpCas9	negative selection	736929
89963342	89963365	14	+	26472758	K562	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	0.0459835615205379	[427]	[372]	0	hSpCas9	negative selection	736930
89963663	89963686	14	-	26472758	K562	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	0.6498527751758951	[828]	[1097]	5	hSpCas9	negative selection	736931
89980597	89980620	14	-	26472758	K562	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	0.32616187710798344	[222]	[235]	2	hSpCas9	negative selection	736932
89963122	89963145	14	+	26627737	DLD1	viability	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.7864408618840878	[232]	[139,184,63]	7	hSpCas9	negative selection	789675
89967371	89967394	14	+	26627737	DLD1	viability	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	-0.486052574765905	[277]	[73,51,59]	-5	hSpCas9	negative selection	789676
89971229	89971252	14	-	26627737	DLD1	viability	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.6390826046296081	[818]	[326,383,472]	6	hSpCas9	negative selection	789677
89980573	89980596	14	-	26627737	DLD1	viability	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.6136112622771455	[975]	[607,412,388]	6	hSpCas9	negative selection	789678
89984627	89984650	14	-	26627737	DLD1	viability	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.41959736747813814	[675]	[123,440,288]	4	hSpCas9	negative selection	789679
89988916	89988939	14	-	26627737	DLD1	viability	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.1521660511357814	[1000]	[641,269,156]	1	hSpCas9	negative selection	789680
89963122	89963145	14	+	26627737	GBM cells	viability after 5 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.25613071977618707	[209]	[145,122]	4	hSpCas9	negative selection	871990
89967371	89967394	14	+	26627737	GBM cells	viability after 5 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	0.23274405882933963	[168]	[132,79]	3	hSpCas9	negative selection	871991
89971229	89971252	14	-	26627737	GBM cells	viability after 5 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.22686575740081782	[477]	[337,261]	3	hSpCas9	negative selection	871992
89980573	89980596	14	-	26627737	GBM cells	viability after 5 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.04173364616540021	[393]	[207,226]	0	hSpCas9	negative selection	871993
89984627	89984650	14	-	26627737	GBM cells	viability after 5 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	-0.11081766313208785	[594]	[276,313]	-2	hSpCas9	negative selection	871994
89988916	89988939	14	-	26627737	GBM cells	viability after 5 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	-0.3940074067220639	[516]	[159,261]	-6	hSpCas9	negative selection	871995
89963122	89963145	14	+	26627737	GBM cells	viability after 13 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.8420498740580082	[209]	[222,188]	8	hSpCas9	negative selection	954305
89967371	89967394	14	+	26627737	GBM cells	viability after 13 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	-0.1063932668708707	[168]	[93,77]	-1	hSpCas9	negative selection	954306
89971229	89971252	14	-	26627737	GBM cells	viability after 13 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.24895248333344122	[477]	[289,322]	3	hSpCas9	negative selection	954307
89980573	89980596	14	-	26627737	GBM cells	viability after 13 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	-0.1982826331000963	[393]	[214,162]	-2	hSpCas9	negative selection	954308
89984627	89984650	14	-	26627737	GBM cells	viability after 13 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.052836131225520555	[594]	[437,250]	0	hSpCas9	negative selection	954309
89988916	89988939	14	-	26627737	GBM cells	viability after 13 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	-0.6511865341367535	[516]	[171,183]	-6	hSpCas9	negative selection	954310
89963122	89963145	14	+	26627737	GBM cells	viability after 21 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.17223592961471335	[209]	[138,118]	1	hSpCas9	negative selection	1036620
89967371	89967394	14	+	26627737	GBM cells	viability after 21 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	-0.6965006103676412	[168]	[52,59]	-6	hSpCas9	negative selection	1036621
89971229	89971252	14	-	26627737	GBM cells	viability after 21 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.4605380405945173	[477]	[360,353]	5	hSpCas9	negative selection	1036622
89980573	89980596	14	-	26627737	GBM cells	viability after 21 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.06130803887053149	[393]	[226,219]	0	hSpCas9	negative selection	1036623
89984627	89984650	14	-	26627737	GBM cells	viability after 21 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	-0.30107192967759033	[594]	[288,237]	-3	hSpCas9	negative selection	1036624
89988916	89988939	14	-	26627737	GBM cells	viability after 21 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	-0.49482841724748194	[516]	[226,173]	-4	hSpCas9	negative selection	1036625
89963122	89963145	14	+	26627737	RPE1	viability after 9 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-0.30360828420887453	[730]	[239,114]	-2	hSpCas9	negative selection	1118935
89967371	89967394	14	+	26627737	RPE1	viability after 9 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	0.2703582878194165	[345]	[79,195]	2	hSpCas9	negative selection	1118936
89971229	89971252	14	-	26627737	RPE1	viability after 9 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.20554704613863467	[1052]	[294,489]	1	hSpCas9	negative selection	1118937
89980573	89980596	14	-	26627737	RPE1	viability after 9 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	-0.3469466734296114	[2800]	[609,791]	-2	hSpCas9	negative selection	1118938
89984627	89984650	14	-	26627737	RPE1	viability after 9 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.28961091867772115	[1516]	[366,855]	2	hSpCas9	negative selection	1118939
89988916	89988939	14	-	26627737	RPE1	viability after 9 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.33855097841273163	[1786]	[513,956]	2	hSpCas9	negative selection	1118940
89963122	89963145	14	+	26627737	RPE1	viability after 12 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.10270137361321466	[730]	[308,106]	0	hSpCas9	negative selection	1201250
89967371	89967394	14	+	26627737	RPE1	viability after 12 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	-0.3806646468218493	[345]	[50,92]	-3	hSpCas9	negative selection	1201251
89971229	89971252	14	-	26627737	RPE1	viability after 12 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.36123629999417456	[1052]	[308,420]	2	hSpCas9	negative selection	1201252
89980573	89980596	14	-	26627737	RPE1	viability after 12 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	-0.4938386588146786	[2800]	[530,537]	-3	hSpCas9	negative selection	1201253
89984627	89984650	14	-	26627737	RPE1	viability after 12 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.09946317124592463	[1516]	[356,520]	0	hSpCas9	negative selection	1201254
89988916	89988939	14	-	26627737	RPE1	viability after 12 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.42709270621319484	[1786]	[475,824]	3	hSpCas9	negative selection	1201255
89963122	89963145	14	+	26627737	RPE1	viability after 15 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-0.37595833524242783	[730]	[167,150]	-2	hSpCas9	negative selection	1283565
89967371	89967394	14	+	26627737	RPE1	viability after 15 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	0.40629623770051837	[345]	[173,86]	2	hSpCas9	negative selection	1283566
89971229	89971252	14	-	26627737	RPE1	viability after 15 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.06693460097651077	[1052]	[282,339]	0	hSpCas9	negative selection	1283567
89980573	89980596	14	-	26627737	RPE1	viability after 15 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	-0.44743136472658485	[2800]	[436,719]	-3	hSpCas9	negative selection	1283568
89984627	89984650	14	-	26627737	RPE1	viability after 15 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.14097802867987363	[1516]	[406,536]	0	hSpCas9	negative selection	1283569
89988916	89988939	14	-	26627737	RPE1	viability after 15 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.5459240746503806	[1786]	[652,819]	3	hSpCas9	negative selection	1283570
89963122	89963145	14	+	26627737	RPE1	viability after 18 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-0.24951426032030585	[730]	[207,120]	-1	hSpCas9	negative selection	1365880
89967371	89967394	14	+	26627737	RPE1	viability after 18 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	-0.4660693145530044	[345]	[84,48]	-3	hSpCas9	negative selection	1365881
89971229	89971252	14	-	26627737	RPE1	viability after 18 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.16062646848936607	[1052]	[379,250]	1	hSpCas9	negative selection	1365882
89980573	89980596	14	-	26627737	RPE1	viability after 18 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	-0.0230922013913617	[2800]	[638,855]	0	hSpCas9	negative selection	1365883
89984627	89984650	14	-	26627737	RPE1	viability after 18 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.029809359313301642	[1516]	[386,450]	0	hSpCas9	negative selection	1365884
89988916	89988939	14	-	26627737	RPE1	viability after 18 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.15916592120826079	[1786]	[290,802]	1	hSpCas9	negative selection	1365885
89963122	89963145	14	+	26627737	HeLa	viability after 8 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.1331381293090976	[455]	[171,137,324]	1	hSpCas9	negative selection	1448195
89967371	89967394	14	+	26627737	HeLa	viability after 8 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	-0.01790817307576842	[293]	[94,192,86]	0	hSpCas9	negative selection	1448196
89971229	89971252	14	-	26627737	HeLa	viability after 8 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	1.0877135810296945	[349]	[255,299,394]	8	hSpCas9	negative selection	1448197
89980573	89980596	14	-	26627737	HeLa	viability after 8 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	-0.6914827925834119	[838]	[327,166,206]	-6	hSpCas9	negative selection	1448198
89984627	89984650	14	-	26627737	HeLa	viability after 8 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	-0.06371909091797301	[794]	[609,270,183]	0	hSpCas9	negative selection	1448199
89988916	89988939	14	-	26627737	HeLa	viability after 8 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.30163181338058376	[686]	[358,356,385]	3	hSpCas9	negative selection	1448200
89963122	89963145	14	+	26627737	HeLa	viability after 12 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-0.3858188126394605	[455]	[276,54,113]	-3	hSpCas9	negative selection	1530510
89967371	89967394	14	+	26627737	HeLa	viability after 12 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	0.011039552037114486	[293]	[138,176,45]	0	hSpCas9	negative selection	1530511
89971229	89971252	14	-	26627737	HeLa	viability after 12 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	1.6506037124068014	[349]	[500,413,452]	9	hSpCas9	negative selection	1530512
89980573	89980596	14	-	26627737	HeLa	viability after 12 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	-0.051052936523521275	[838]	[419,329,256]	0	hSpCas9	negative selection	1530513
89984627	89984650	14	-	26627737	HeLa	viability after 12 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	-0.1798638712456464	[794]	[328,263,280]	-1	hSpCas9	negative selection	1530514
89988916	89988939	14	-	26627737	HeLa	viability after 12 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.4804228339378318	[686]	[524,339,332]	4	hSpCas9	negative selection	1530515
89963122	89963145	14	+	26627737	HeLa	viability after 15 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-0.24934322623220073	[455]	[212,83,171]	-2	hSpCas9	negative selection	1612825
89967371	89967394	14	+	26627737	HeLa	viability after 15 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	-0.987209090975655	[293]	[50,84,43]	-7	hSpCas9	negative selection	1612826
89971229	89971252	14	-	26627737	HeLa	viability after 15 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	1.4383641267301182	[349]	[236,384,550]	8	hSpCas9	negative selection	1612827
89980573	89980596	14	-	26627737	HeLa	viability after 15 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	-0.6218077491884502	[838]	[290,139,234]	-5	hSpCas9	negative selection	1612828
89984627	89984650	14	-	26627737	HeLa	viability after 15 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.16245925805567096	[794]	[318,444,319]	1	hSpCas9	negative selection	1612829
89988916	89988939	14	-	26627737	HeLa	viability after 15 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.5649649188637198	[686]	[303,411,535]	4	hSpCas9	negative selection	1612830
89963122	89963145	14	+	26627737	HeLa	viability after 18 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-0.24535684252671608	[455]	[140,72,171]	-2	hSpCas9	negative selection	1695140
89967371	89967394	14	+	26627737	HeLa	viability after 18 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	-0.8821103512423978	[293]	[36,77,43]	-6	hSpCas9	negative selection	1695141
89971229	89971252	14	-	26627737	HeLa	viability after 18 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	1.4694282568799957	[349]	[163,332,550]	8	hSpCas9	negative selection	1695142
89980573	89980596	14	-	26627737	HeLa	viability after 18 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	-0.6379043925741139	[838]	[191,113,234]	-5	hSpCas9	negative selection	1695143
89984627	89984650	14	-	26627737	HeLa	viability after 18 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.1980226538473724	[794]	[223,377,319]	1	hSpCas9	negative selection	1695144
89988916	89988939	14	-	26627737	HeLa	viability after 18 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.5744499848101472	[686]	[202,348,535]	4	hSpCas9	negative selection	1695145
89963122	89963145	14	+	26627737	HCT116	viability after 6 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	1.1797113759526197	[597]	[172,234]	6	hSpCas9	negative selection	1777455
89967371	89967394	14	+	26627737	HCT116	viability after 6 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	-0.08142572750796823	[467]	[55,76]	0	hSpCas9	negative selection	1777456
89971229	89971252	14	-	26627737	HCT116	viability after 6 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.7306877800450747	[1055]	[444,181]	4	hSpCas9	negative selection	1777457
89980573	89980596	14	-	26627737	HCT116	viability after 6 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.3709101234080887	[1480]	[215,347]	2	hSpCas9	negative selection	1777458
89984627	89984650	14	-	26627737	HCT116	viability after 6 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	-0.5605822081743026	[698]	[98,60]	-3	hSpCas9	negative selection	1777459
89988916	89988939	14	-	26627737	HCT116	viability after 6 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.7504777128780313	[1172]	[384,268]	4	hSpCas9	negative selection	1777460
89963122	89963145	14	+	26627737	HCT116	viability after 8 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-0.9813840506906322	[557]	[151,230,84]	-8	hSpCas9	negative selection	1859770
89967371	89967394	14	+	26627737	HCT116	viability after 8 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	0.007120275458173064	[172]	[106,117,62]	0	hSpCas9	negative selection	1859771
89971229	89971252	14	-	26627737	HCT116	viability after 8 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.5973303038709986	[441]	[470,328,307]	6	hSpCas9	negative selection	1859772
89980573	89980596	14	-	26627737	HCT116	viability after 8 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.013587412296691803	[516]	[289,303,268]	0	hSpCas9	negative selection	1859773
89984627	89984650	14	-	26627737	HCT116	viability after 8 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.7894516816702556	[369]	[418,339,299]	7	hSpCas9	negative selection	1859774
89988916	89988939	14	-	26627737	HCT116	viability after 8 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.35645034702184675	[637]	[391,488,467]	4	hSpCas9	negative selection	1859775
89963122	89963145	14	+	26627737	HCT116	viability after 9 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.9747393810668434	[597]	[410,236]	6	hSpCas9	negative selection	1942085
89967371	89967394	14	+	26627737	HCT116	viability after 9 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	-1.9564668555385514	[467]	[15,44]	-8	hSpCas9	negative selection	1942086
89971229	89971252	14	-	26627737	HCT116	viability after 9 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.6869437671982851	[1055]	[506,411]	5	hSpCas9	negative selection	1942087
89980573	89980596	14	-	26627737	HCT116	viability after 9 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	-0.34459073031210774	[1480]	[230,374]	-2	hSpCas9	negative selection	1942088
89984627	89984650	14	-	26627737	HCT116	viability after 9 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	1.399887054714872	[698]	[415,552]	8	hSpCas9	negative selection	1942089
89988916	89988939	14	-	26627737	HCT116	viability after 9 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	1.2202743666817502	[1172]	[836,644]	7	hSpCas9	negative selection	1942090
89963122	89963145	14	+	26627737	HCT116	viability after 12 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-0.8888911627629098	[557]	[153,262,60]	-7	hSpCas9	negative selection	2024400
89967371	89967394	14	+	26627737	HCT116	viability after 12 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	0.15593187452603452	[172]	[135,66,96]	1	hSpCas9	negative selection	2024401
89971229	89971252	14	-	26627737	HCT116	viability after 12 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.9265495257489741	[441]	[524,268,518]	7	hSpCas9	negative selection	2024402
89980573	89980596	14	-	26627737	HCT116	viability after 12 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	-0.024517940925978143	[516]	[262,319,219]	0	hSpCas9	negative selection	2024403
89984627	89984650	14	-	26627737	HCT116	viability after 12 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.7456448782046682	[369]	[295,295,387]	6	hSpCas9	negative selection	2024404
89988916	89988939	14	-	26627737	HCT116	viability after 12 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.5228275386402466	[637]	[478,422,541]	5	hSpCas9	negative selection	2024405
89963122	89963145	14	+	26627737	HCT116	viability after 15 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-1.4192118574573342	[557]	[132,184,43]	-8	hSpCas9	negative selection	2106715
89967371	89967394	14	+	26627737	HCT116	viability after 15 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	0.03325503595810719	[172]	[135,138,34]	0	hSpCas9	negative selection	2106716
89971229	89971252	14	-	26627737	HCT116	viability after 15 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.5982654352849569	[441]	[593,168,414]	5	hSpCas9	negative selection	2106717
89980573	89980596	14	-	26627737	HCT116	viability after 15 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	-0.06705335587754202	[516]	[285,314,249]	0	hSpCas9	negative selection	2106718
89984627	89984650	14	-	26627737	HCT116	viability after 15 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.4541953535590144	[369]	[290,263,317]	4	hSpCas9	negative selection	2106719
89988916	89988939	14	-	26627737	HCT116	viability after 15 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.378780804467592	[637]	[613,606,227]	3	hSpCas9	negative selection	2106720
89963122	89963145	14	+	26627737	HCT116	viability after 18 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-0.7051530504880205	[557]	[117,196,179]	-6	hSpCas9	negative selection	2189030
89967371	89967394	14	+	26627737	HCT116	viability after 18 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	-0.1846180746562962	[172]	[134,54,29]	-2	hSpCas9	negative selection	2189031
89971229	89971252	14	-	26627737	HCT116	viability after 18 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	1.0026352054660643	[441]	[678,174,447]	7	hSpCas9	negative selection	2189032
89980573	89980596	14	-	26627737	HCT116	viability after 18 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.7011657658932695	[516]	[645,265,311]	6	hSpCas9	negative selection	2189033
89984627	89984650	14	-	26627737	HCT116	viability after 18 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.33544789272817466	[369]	[209,155,319]	3	hSpCas9	negative selection	2189034
89988916	89988939	14	-	26627737	HCT116	viability after 18 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.40058119916205004	[637]	[429,495,283]	3	hSpCas9	negative selection	2189035
89963102	89963125	14	+	24336569	HL60	viability	TTCCAGGAGTATAATGTCTCAGG	TDP1	ENSG00000042088	-0.33932446012475326	[500]	[837]	-3	hSpCas9	negative selection	2299621
89963115	89963138	14	+	24336569	HL60	viability	ATGTCTCAGGAAGGCGATTATGG	TDP1	ENSG00000042088	0.8581037689342199	[517]	[1986]	7	hSpCas9	negative selection	2299622
89963122	89963145	14	+	24336569	HL60	viability	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-0.400667558179723	[528]	[847]	-4	hSpCas9	negative selection	2299623
89963146	89963169	14	-	24336569	HL60	viability	ACTTTCATCACTACTAGATATGG	TDP1	ENSG00000042088	-0.0015405563319470517	[236]	[500]	0	hSpCas9	negative selection	2299624
89963187	89963210	14	-	24336569	HL60	viability	GAAGAGGTAGATGGCTTGTCTGG	TDP1	ENSG00000042088	0.2491375376634486	[1193]	[3002]	2	hSpCas9	negative selection	2299625
89963196	89963219	14	-	24336569	HL60	viability	CAGAGAAGAGAAGAGGTAGATGG	TDP1	ENSG00000042088	0.5780203433585711	[414]	[1310]	5	hSpCas9	negative selection	2299626
89963203	89963226	14	-	24336569	HL60	viability	CCTGGCACAGAGAAGAGAAGAGG	TDP1	ENSG00000042088	-0.8117922428729579	[505]	[609]	-6	hSpCas9	negative selection	2299627
89963208	89963231	14	+	24336569	HL60	viability	TCTCTTCTCTGTGCCAGGCAAGG	TDP1	ENSG00000042088	-0.18334371464810995	[329]	[614]	-1	hSpCas9	negative selection	2299628
89963221	89963244	14	-	24336569	HL60	viability	CTCATTTGCTGCTCCTTGCCTGG	TDP1	ENSG00000042088	-0.779573758978079	[695]	[857]	-6	hSpCas9	negative selection	2299629
89963227	89963250	14	+	24336569	HL60	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	-0.3093788063763868	[697]	[1191]	-3	hSpCas9	negative selection	2299630
89963102	89963125	14	+	24336569	KBM7	viability	TTCCAGGAGTATAATGTCTCAGG	TDP1	ENSG00000042088	0.07376720487630206	[169]	[487]	0	hSpCas9	negative selection	2366798
89963115	89963138	14	+	24336569	KBM7	viability	ATGTCTCAGGAAGGCGATTATGG	TDP1	ENSG00000042088	0.36037126526573926	[691]	[2422]	3	hSpCas9	negative selection	2366799
89963122	89963145	14	+	24336569	KBM7	viability	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.7267109974548316	[219]	[992]	6	hSpCas9	negative selection	2366800
89963146	89963169	14	-	24336569	KBM7	viability	ACTTTCATCACTACTAGATATGG	TDP1	ENSG00000042088	1.714227071926526	[98]	[885]	9	hSpCas9	negative selection	2366801
89963187	89963210	14	-	24336569	KBM7	viability	GAAGAGGTAGATGGCTTGTCTGG	TDP1	ENSG00000042088	0.14690238225226726	[855]	[2584]	1	hSpCas9	negative selection	2366802
89963196	89963219	14	-	24336569	KBM7	viability	CAGAGAAGAGAAGAGGTAGATGG	TDP1	ENSG00000042088	-0.6395210353640763	[292]	[512]	-5	hSpCas9	negative selection	2366803
89963203	89963226	14	-	24336569	KBM7	viability	CCTGGCACAGAGAAGAGAAGAGG	TDP1	ENSG00000042088	0.5423319858275336	[286]	[1139]	5	hSpCas9	negative selection	2366804
89963208	89963231	14	+	24336569	KBM7	viability	TCTCTTCTCTGTGCCAGGCAAGG	TDP1	ENSG00000042088	0.3948795264646376	[260]	[935]	3	hSpCas9	negative selection	2366805
89963221	89963244	14	-	24336569	KBM7	viability	CTCATTTGCTGCTCCTTGCCTGG	TDP1	ENSG00000042088	1.0849564555752875	[438]	[2539]	8	hSpCas9	negative selection	2366806
89963227	89963250	14	+	24336569	KBM7	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	-0.15052577030054937	[467]	[1149]	-1	hSpCas9	negative selection	2366807
89955782	89955805	14	-	25494202	A375	resistance to PLX-4720 (puromycin)	AGGACGGGGCTGGGGAAACCTGG	TDP1	ENSG00000042088	2.7172754803164434	[353,10]	[483,18]	8	dCas9-VP64	positive selection	2388249
89955764	89955787	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCCAAGAGCTAGGAGAGACCAGG	TDP1	ENSG00000042088	3.006963651464921	[4,3]	[2,12]	8	dCas9-VP64	positive selection	2388250
89955807	89955830	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	GTAAACACCCGGCGGGCTTTAGG	TDP1	ENSG00000042088	3.181224307554332	[48,255]	[4,636]	8	dCas9-VP64	positive selection	2388251
90031565	90031588	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	GAGAACTGCTTGAACCCGGGTGG	TDP1	ENSG00000042088	-0.49490286023555685	[54,83]	[3,16]	-2	dCas9-VP64	positive selection	2421107
89954925	89954948	14	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGAGTTAAGGGACAGTCAGGGGG	TDP1	ENSG00000042088	-0.9178686694787404	[470,108]	[44,20]	-5	dCas9-VP64	positive selection	2423160
90029697	90029720	14	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGAGACCAGCCTGATCAACATAG	TDP1	ENSG00000042088	-0.08492757567810244	[180,53]	[21,25]	0	dCas9-VP64	positive selection	2451937
90016285	90016308	14	-	25494202	A375	resistance to PLX-4720 (puromycin)	ACTTTGGGAGGCCAAGGCAGCGG	TDP1	ENSG00000042088	2.0119762381202047	[93,200]	[9,263]	7	dCas9-VP64	positive selection	2462449
89955782	89955805	14	-	25494202	A375	resistance to PLX-4720 (zeocin)	AGGACGGGGCTGGGGAAACCTGG	TDP1	ENSG00000042088	-0.44627811476039503	[72,41]	[17,8]	-5	dCas9-VP64	positive selection	2483504
89955764	89955787	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCCAAGAGCTAGGAGAGACCAGG	TDP1	ENSG00000042088	0.9260214558567039	[159,87]	[143,14]	6	dCas9-VP64	positive selection	2483505
89955807	89955830	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	GTAAACACCCGGCGGGCTTTAGG	TDP1	ENSG00000042088	-1.298332737362149	[19,158]	[11,9]	-9	dCas9-VP64	positive selection	2483506
90031565	90031588	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	GAGAACTGCTTGAACCCGGGTGG	TDP1	ENSG00000042088	0.07163893759037979	[96,162]	[32,54]	0	dCas9-VP64	positive selection	2516362
89954925	89954948	14	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGAGTTAAGGGACAGTCAGGGGG	TDP1	ENSG00000042088	-0.5935202766946864	[118,276]	[36,46]	-6	dCas9-VP64	positive selection	2518415
90029697	90029720	14	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGAGACCAGCCTGATCAACATAG	TDP1	ENSG00000042088	-0.6769120761823355	[84,46]	[15,9]	-6	dCas9-VP64	positive selection	2547192
90016285	90016308	14	-	25494202	A375	resistance to PLX-4720 (zeocin)	ACTTTGGGAGGCCAAGGCAGCGG	TDP1	ENSG00000042088	-0.4547686614086857	[146,265]	[55,41]	-5	dCas9-VP64	positive selection	2557704
89980612	89980635	14	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ACTGGCACCAGAAAACTCAAGGG	TDP1	ENSG00000042088	0.12572809017892955	[3,4]	[4,3]	2	hSpCas9	positive selection	3026089
89980570	89980593	14	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.46539979754400074	[1,1]	[0,0]	-6	hSpCas9	positive selection	3026090
89963203	89963226	14	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CCTGGCACAGAGAAGAGAAGAGG	TDP1	ENSG00000042088	-0.18641685388401005	[2,3]	[3,0]	-3	hSpCas9	positive selection	3026091
89963244	89963267	14	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCCCAGGTACACCTGTTCCGAGG	TDP1	ENSG00000042088	0.030397843161495824	[3,3]	[2,3]	0	hSpCas9	positive selection	3026092
89980612	89980635	14	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ACTGGCACCAGAAAACTCAAGGG	TDP1	ENSG00000042088	-0.031786120353306344	[3,3]	[4,1]	0	hSpCas9	positive selection	3093947
89980570	89980593	14	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.537014430491294	[1,1]	[0,0]	-7	hSpCas9	positive selection	3093948
89963203	89963226	14	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CCTGGCACAGAGAAGAGAAGAGG	TDP1	ENSG00000042088	-0.34628180055487645	[2,2]	[2,0]	-5	hSpCas9	positive selection	3093949
89963244	89963267	14	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCCCAGGTACACCTGTTCCGAGG	TDP1	ENSG00000042088	0.9193732796864125	[3,3]	[4,5]	9	hSpCas9	positive selection	3093950
89967401	89967424		+	24336571	A375	resistance to PLX after 7 days	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.04241460182988621	[16,19]	[19,17]	1	hSpCas9	positive selection	3149600
89966169	89966192		+	24336571	A375	resistance to PLX after 7 days	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.05099968973103741	[3,3]	[3,3]	1	hSpCas9	positive selection	3149601
89967401	89967424		+	24336571	A375	resistance to PLX after 14 days	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	1.8671224321258124	[16,16]	[24,34]	9	hSpCas9	positive selection	3207393
89966169	89966192		+	24336571	A375	resistance to PLX after 14 days	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.05281327713923645	[4,3]	[1,1]	0	hSpCas9	positive selection	3207394
89967401	89967424		+	24336571	A375	viability after 7 days	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.441750088149259	[13]	[16,19]	6	hSpCas9	negative selection	3265186
89966169	89966192		+	24336571	A375	viability after 7 days	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.5244141920787657	[2]	[3,3]	7	hSpCas9	negative selection	3265187
89967401	89967424		+	24336571	A375	viability after 14 days	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.33896249987385674	[13]	[16,16]	4	hSpCas9	negative selection	3322979
89966169	89966192		+	24336571	A375	viability after 14 days	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.779145286428514	[2]	[4,3]	8	hSpCas9	negative selection	3322980
89967401	89967424	14	+	27383988	293T	resistance to West Nile virus (flavivirus)	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.2425196756373702	[180,180]	[0,0]	-1	hSpCas9	positive selection	3396644
89966169	89966192	14	+	27383988	293T	resistance to West Nile virus (flavivirus)	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.8143827155971068	[86,86]	[0,0]	4	hSpCas9	positive selection	3396645
89966158	89966181	14	-	27383988	293T	resistance to West Nile virus (flavivirus)	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	1.3031299010589596	[61,61]	[0,0]	5	hSpCas9	positive selection	3396646
89980611	89980634	14	+	26780180	HT29	viability (Avana library 4 designs)	ACTGGCACCAGAAAACTCAAGGG	TDP1	ENSG00000042088	0.440742772164886	[]	[]	1	hSpCas9	negative selection	3464813
89980570	89980593	14	-	26780180	HT29	viability (Avana library 4 designs)	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.241713801099202	[]	[]	0	hSpCas9	negative selection	3464814
89963203	89963226	14	-	26780180	HT29	viability (Avana library 4 designs)	CCTGGCACAGAGAAGAGAAGAGG	TDP1	ENSG00000042088	1.95562597398923	[]	[]	7	hSpCas9	negative selection	3464815
89963243	89963266	14	+	26780180	HT29	viability (Avana library 4 designs)	GCCCAGGTACACCTGTTCCGAGG	TDP1	ENSG00000042088	0.657114856977592	[]	[]	2	hSpCas9	negative selection	3464816
89963203	89963226	14	-	26780180	A375	viability (Avana lentiCRISPRv2)	CCTGGCACAGAGAAGAGAAGAGG	TDP1	ENSG00000042088	0.697886037614184	[]	[]	1	hSpCas9	negative selection	3567701
89963243	89963266	14	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCCCAGGTACACCTGTTCCGAGG	TDP1	ENSG00000042088	6.04237897293384	[]	[]	9	hSpCas9	negative selection	3567702
89980570	89980593	14	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	2.7350899383893	[]	[]	4	hSpCas9	negative selection	3567703
89980611	89980634	14	+	26780180	A375	viability (Avana lentiCRISPRv2)	ACTGGCACCAGAAAACTCAAGGG	TDP1	ENSG00000042088	-5.62393605921466	[]	[]	-6	hSpCas9	negative selection	3567704
89963331	89963354	14	+	26780180	A375	viability (Avana lentiCRISPRv2)	CCTCCCAAAAGGCAGAAAAGCGG	TDP1	ENSG00000042088	1.70388212107705	[]	[]	2	hSpCas9	negative selection	3567705
89967366	89967389	14	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-2.09070775388095	[]	[]	-3	hSpCas9	negative selection	3567706
89963203	89963226	14	-	26780180	A375	viability (Avana lentiGuide)	CCTGGCACAGAGAAGAGAAGAGG	TDP1	ENSG00000042088	10.7072566169864	[]	[]	7	hSpCas9	negative selection	3676360
89963243	89963266	14	+	26780180	A375	viability (Avana lentiGuide)	GCCCAGGTACACCTGTTCCGAGG	TDP1	ENSG00000042088	-3.28940318011327	[]	[]	-6	hSpCas9	negative selection	3676361
89980570	89980593	14	-	26780180	A375	viability (Avana lentiGuide)	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	15.2818767069161	[]	[]	8	hSpCas9	negative selection	3676362
89980611	89980634	14	+	26780180	A375	viability (Avana lentiGuide)	ACTGGCACCAGAAAACTCAAGGG	TDP1	ENSG00000042088	1.15692782190159	[]	[]	1	hSpCas9	negative selection	3676363
89963331	89963354	14	+	26780180	A375	viability (Avana lentiGuide)	CCTCCCAAAAGGCAGAAAAGCGG	TDP1	ENSG00000042088	-1.3598607309107	[]	[]	-2	hSpCas9	negative selection	3676364
89967366	89967389	14	+	26780180	A375	viability (Avana lentiGuide)	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.170935469071998	[]	[]	0	hSpCas9	negative selection	3676365
89963203	89963226	14	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCTGGCACAGAGAAGAGAAGAGG	TDP1	ENSG00000042088	-0.236676861131587	[4]	[3,2]	-4	hSpCas9	positive selection	3784967
89963243	89963266	14	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCCCAGGTACACCTGTTCCGAGG	TDP1	ENSG00000042088	0.28209880059022957	[4]	[5,5]	7	hSpCas9	positive selection	3784968
89980570	89980593	14	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.2118597928618703	[3]	[4,4]	6	hSpCas9	positive selection	3784969
89980611	89980634	14	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ACTGGCACCAGAAAACTCAAGGG	TDP1	ENSG00000042088	-0.3951490540362645	[5]	[4,2]	-5	hSpCas9	positive selection	3784970
89963331	89963354	14	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCTCCCAAAAGGCAGAAAAGCGG	TDP1	ENSG00000042088	0.23372573693052623	[5]	[6,6]	6	hSpCas9	positive selection	3784971
89967366	89967389	14	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.35283539009689474	[5]	[3,4]	-5	hSpCas9	positive selection	3784972
89963203	89963226	14	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCTGGCACAGAGAAGAGAAGAGG	TDP1	ENSG00000042088	-0.1662956242432177	[4]	[4,2]	-2	hSpCas9	positive selection	3893574
89963243	89963266	14	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCCCAGGTACACCTGTTCCGAGG	TDP1	ENSG00000042088	-1.5421135583991223	[5]	[0,0]	-9	hSpCas9	positive selection	3893575
89980570	89980593	14	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.6721437919454243	[3]	[2,0]	-7	hSpCas9	positive selection	3893576
89980611	89980634	14	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ACTGGCACCAGAAAACTCAAGGG	TDP1	ENSG00000042088	0.2963814640998765	[5]	[5,5]	8	hSpCas9	positive selection	3893577
89963331	89963354	14	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCTCCCAAAAGGCAGAAAAGCGG	TDP1	ENSG00000042088	0.045508131773187493	[5]	[4,5]	1	hSpCas9	positive selection	3893578
89967366	89967389	14	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.04060644397001814	[5]	[5,3]	0	hSpCas9	positive selection	3893579
89967401	89967424	14	+	26780180	A375	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	1.34028156375244	[]	[]	7	hSpCas9	negative selection	4002920
89971179	89971202	14	+	26780180	A375	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	1.12245279636258	[]	[]	5	hSpCas9	negative selection	4002921
89971245	89971268	14	-	26780180	A375	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.836045907364173	[]	[]	3	hSpCas9	negative selection	4002922
89966158	89966181	14	-	26780180	A375	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.858299490161063	[]	[]	3	hSpCas9	negative selection	4002923
89966169	89966192	14	+	26780180	A375	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.733316753830139	[]	[]	2	hSpCas9	negative selection	4002924
89967366	89967389	14	+	26780180	A375	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.958314590248639	[]	[]	4	hSpCas9	negative selection	4002925
89967401	89967424	14	+	26780180	HT29	viability (GeCKOv2 library)	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	1.6099219069178	[]	[]	8	hSpCas9	negative selection	4110886
89971179	89971202	14	+	26780180	HT29	viability (GeCKOv2 library)	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	1.03371931545727	[]	[]	5	hSpCas9	negative selection	4110887
89971245	89971268	14	-	26780180	HT29	viability (GeCKOv2 library)	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	1.31382837904423	[]	[]	6	hSpCas9	negative selection	4110888
89966158	89966181	14	-	26780180	HT29	viability (GeCKOv2 library)	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	1.32407353243738	[]	[]	6	hSpCas9	negative selection	4110889
89966169	89966192	14	+	26780180	HT29	viability (GeCKOv2 library)	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.844433476129929	[]	[]	3	hSpCas9	negative selection	4110890
89967366	89967389	14	+	26780180	HT29	viability (GeCKOv2 library)	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.231786751684709	[]	[]	0	hSpCas9	negative selection	4110891
89967401	89967424	14	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.38779502500229046	[4]	[2,4]	8	hSpCas9	positive selection	4175945
89966169	89966192	14	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	-0.47422964395153433	[3]	[1,0]	-8	hSpCas9	positive selection	4175946
89967401	89967424	14	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.8060126640633125	[4]	[0,0,0,0]	-9	hSpCas9	positive selection	4239967
89966169	89966192	14	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.3591324033507107	[1]	[0,2,0,0]	2	hSpCas9	positive selection	4239968
89971179	89971202	14	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	-0.1949406311327975	[2]	[2,0]	-4	hSpCas9	positive selection	4302511
89967366	89967389	14	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.3880260481613199	[2]	[2,0]	-7	hSpCas9	positive selection	4302512
89971245	89971268	14	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.16296265774886684	[2]	[2,1]	3	hSpCas9	positive selection	4302513
89967401	89967424	14	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.3234040101945285	[3]	[2,0]	-6	hSpCas9	positive selection	4366765
89966169	89966192	14	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.5829001398453457	[1]	[2,2]	9	hSpCas9	positive selection	4366766
89966158	89966181	14	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.14306115717667545	[1]	[2,1]	3	hSpCas9	positive selection	4366767
89963539	89963561	14	+	27760321	OCIAML3	viability	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	0.349869932207314	[0,0]	[0,0]	4	hSpCas9	negative selection	4446069
89966158	89966180	14	-	27760321	OCIAML3	viability	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.9650288411519885	[84,70]	[138,91]	9	hSpCas9	negative selection	4446070
89971194	89971216	14	+	27760321	OCIAML3	viability	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	-0.3884009680324477	[289,258]	[168,156]	-4	hSpCas9	negative selection	4446071
89980570	89980592	14	-	27760321	OCIAML3	viability	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	1.083864101587005	[221,184]	[249,447]	9	hSpCas9	negative selection	4446072
89984528	89984550	14	-	27760321	OCIAML3	viability	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	-0.31055482775294596	[265,222]	[107,212]	-3	hSpCas9	negative selection	4446073
89963539	89963561	14	+	27760321	OCIAML2	viability	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	0.3011245669422653	[0,0]	[0,0]	4	hSpCas9	negative selection	4529532
89966158	89966180	14	-	27760321	OCIAML2	viability	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.26769038844193327	[84,70]	[43,62]	-3	hSpCas9	negative selection	4529533
89971194	89971216	14	+	27760321	OCIAML2	viability	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	0.38849621272096724	[289,258]	[247,345]	5	hSpCas9	negative selection	4529534
89980570	89980592	14	-	27760321	OCIAML2	viability	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.11608462569773625	[221,184]	[162,196]	1	hSpCas9	negative selection	4529535
89984528	89984550	14	-	27760321	OCIAML2	viability	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	0.3679020978963716	[265,222]	[239,272]	5	hSpCas9	negative selection	4529536
89963539	89963561	14	+	27760321	MV411	viability	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	0.5949485011219959	[0,0]	[0,0]	4	hSpCas9	negative selection	4612995
89966158	89966180	14	-	27760321	MV411	viability	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.0359954751892726	[84,70]	[0,129]	0	hSpCas9	negative selection	4612996
89971194	89971216	14	+	27760321	MV411	viability	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	-1.2862535157518065	[289,258]	[38,126]	-7	hSpCas9	negative selection	4612997
89980570	89980592	14	-	27760321	MV411	viability	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.13403072698440888	[221,184]	[83,240]	0	hSpCas9	negative selection	4612998
89984528	89984550	14	-	27760321	MV411	viability	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	-0.18899420707743242	[265,222]	[114,179]	-1	hSpCas9	negative selection	4612999
89963539	89963561	14	+	27760321	HL60	viability	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	0.2870783393278593	[0,0]	[0,0]	3	hSpCas9	negative selection	4696458
89966158	89966180	14	-	27760321	HL60	viability	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-2.1137713299726046	[84,70]	[19,8]	-9	hSpCas9	negative selection	4696459
89971194	89971216	14	+	27760321	HL60	viability	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	-0.5225849886329127	[289,258]	[151,159]	-5	hSpCas9	negative selection	4696460
89980570	89980592	14	-	27760321	HL60	viability	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.11547533334866567	[221,184]	[206,149]	1	hSpCas9	negative selection	4696461
89984528	89984550	14	-	27760321	HL60	viability	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	-0.5757931210575027	[265,222]	[115,151]	-6	hSpCas9	negative selection	4696462
89963539	89963561	14	+	27760321	HT1080	viability	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	1.3056276939190559	[0,0]	[0,0]	7	hSpCas9	negative selection	4779921
89966158	89966180	14	-	27760321	HT1080	viability	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-1.0793621219334955	[70,55]	[0,23]	-4	hSpCas9	negative selection	4779922
89971194	89971216	14	+	27760321	HT1080	viability	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	1.7107029974352124	[258,201]	[427,160]	8	hSpCas9	negative selection	4779923
89980570	89980592	14	-	27760321	HT1080	viability	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.028319630461671075	[184,144]	[105,18]	0	hSpCas9	negative selection	4779924
89984528	89984550	14	-	27760321	HT1080	viability	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	-1.6588888450402761	[222,173]	[46,0]	-5	hSpCas9	negative selection	4779925
89963539	89963561	14	+	27760321	HT29	viability after 7 days	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	1.7080535000916273	[0,0]	[11,0,0]	9	hSpCas9	negative selection	4863384
89966158	89966180	14	-	27760321	HT29	viability after 7 days	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.4909576516568772	[70,55]	[64,42,66]	-6	hSpCas9	negative selection	4863385
89971194	89971216	14	+	27760321	HT29	viability after 7 days	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	0.037558986494803825	[258,201]	[258,227,414]	0	hSpCas9	negative selection	4863386
89980570	89980592	14	-	27760321	HT29	viability after 7 days	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.002214129741005655	[184,144]	[288,230,128]	0	hSpCas9	negative selection	4863387
89984528	89984550	14	-	27760321	HT29	viability after 7 days	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	0.014402093098932589	[222,173]	[359,216,211]	0	hSpCas9	negative selection	4863388
89963539	89963561	14	+	27760321	HT29	viability after 25 days	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	-0.21405457092746794	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	4946847
89966158	89966180	14	-	27760321	HT29	viability after 25 days	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.15785132180055061	[70,55]	[29,118,98]	1	hSpCas9	negative selection	4946848
89971194	89971216	14	+	27760321	HT29	viability after 25 days	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	0.38054379257339815	[258,201]	[359,359,302]	4	hSpCas9	negative selection	4946849
89980570	89980592	14	-	27760321	HT29	viability after 25 days	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.4695923085020737	[184,144]	[235,379,157]	5	hSpCas9	negative selection	4946850
89984528	89984550	14	-	27760321	HT29	viability after 25 days	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	0.45923953496173064	[222,173]	[218,254,484]	5	hSpCas9	negative selection	4946851
89963539	89963561	14	+	27760321	HT29	viability after 22 days	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	-0.23137320278672746	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	5030310
89966158	89966180	14	-	27760321	HT29	viability after 22 days	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.5932148457555448	[70,55]	[16,73,55]	-5	hSpCas9	negative selection	5030311
89971194	89971216	14	+	27760321	HT29	viability after 22 days	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	-0.585421540816401	[258,201]	[189,206,134]	-5	hSpCas9	negative selection	5030312
89980570	89980592	14	-	27760321	HT29	viability after 22 days	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.13125153418953728	[184,144]	[308,136,71]	-1	hSpCas9	negative selection	5030313
89984528	89984550	14	-	27760321	HT29	viability after 22 days	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	-0.3109958065990802	[222,173]	[184,175,193]	-3	hSpCas9	negative selection	5030314
89963539	89963561	14	+	27760321	HT29	viability after 19 days	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	-0.21553315036351428	[0,0]	[0,0,0]	-2	hSpCas9	negative selection	5113773
89966158	89966180	14	-	27760321	HT29	viability after 19 days	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-2.0208898885248834	[70,55]	[1,30,18]	-8	hSpCas9	negative selection	5113774
89971194	89971216	14	+	27760321	HT29	viability after 19 days	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	0.6212761002391091	[258,201]	[515,419,295]	6	hSpCas9	negative selection	5113775
89980570	89980592	14	-	27760321	HT29	viability after 19 days	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.4034025825551286	[184,144]	[291,124,30]	-4	hSpCas9	negative selection	5113776
89984528	89984550	14	-	27760321	HT29	viability after 19 days	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	-0.21045952944710777	[222,173]	[338,190,77]	-2	hSpCas9	negative selection	5113777
89963539	89963561	14	+	27760321	HT29	viability after 16 days	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	0.20426605822408384	[0,0]	[1,0,0]	2	hSpCas9	negative selection	5197236
89966158	89966180	14	-	27760321	HT29	viability after 16 days	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.14864834918696168	[70,55]	[49,104,77]	1	hSpCas9	negative selection	5197237
89971194	89971216	14	+	27760321	HT29	viability after 16 days	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	0.1735863954213469	[258,201]	[450,122,317]	1	hSpCas9	negative selection	5197238
89980570	89980592	14	-	27760321	HT29	viability after 16 days	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.05724271572874118	[184,144]	[144,150,233]	0	hSpCas9	negative selection	5197239
89984528	89984550	14	-	27760321	HT29	viability after 16 days	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	0.32568294484722093	[222,173]	[216,244,367]	3	hSpCas9	negative selection	5197240
89963539	89963561	14	+	27760321	HT29	viability after 13 days	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	-0.23635609738673047	[0,0]	[0,0,0]	-3	hSpCas9	negative selection	5280699
89966158	89966180	14	-	27760321	HT29	viability after 13 days	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.19539191194012018	[70,55]	[20,158,73]	2	hSpCas9	negative selection	5280700
89971194	89971216	14	+	27760321	HT29	viability after 13 days	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	0.18281506719181423	[258,201]	[445,174,289]	2	hSpCas9	negative selection	5280701
89980570	89980592	14	-	27760321	HT29	viability after 13 days	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.1642976912586651	[184,144]	[182,200,130]	-2	hSpCas9	negative selection	5280702
89984528	89984550	14	-	27760321	HT29	viability after 13 days	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	-0.053831093519782436	[222,173]	[262,224,179]	0	hSpCas9	negative selection	5280703
89963539	89963561	14	+	27760321	HT29	viability after 10 days	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	-0.34236740454707437	[0,0]	[0,0,0]	-4	hSpCas9	negative selection	5364162
89966158	89966180	14	-	27760321	HT29	viability after 10 days	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.07645250331047837	[70,55]	[53,77,117]	1	hSpCas9	negative selection	5364163
89971194	89971216	14	+	27760321	HT29	viability after 10 days	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	0.04411033798074793	[258,201]	[331,258,297]	0	hSpCas9	negative selection	5364164
89980570	89980592	14	-	27760321	HT29	viability after 10 days	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.456818799542833	[184,144]	[134,88,222]	-5	hSpCas9	negative selection	5364165
89984528	89984550	14	-	27760321	HT29	viability after 10 days	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	-0.2661923435628585	[222,173]	[297,160,158]	-3	hSpCas9	negative selection	5364166
89963539	89963561	14	+	27760321	MOLM13	viability	AAGACGAGTATGAGACATCAGG	TDP1	ENSG00000042088	0.8210053139495912	[0,0]	[0,0]	6	hSpCas9	negative selection	5447625
89966158	89966180	14	-	27760321	MOLM13	viability	AAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	1.757292948847387	[84,70]	[266,46]	9	hSpCas9	negative selection	5447626
89971194	89971216	14	+	27760321	MOLM13	viability	GTGCATGGTGATAAGCGAGAGG	TDP1	ENSG00000042088	-0.13770491874020774	[289,258]	[199,89]	-1	hSpCas9	negative selection	5447627
89980570	89980592	14	-	27760321	MOLM13	viability	GGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-1.0452528696877783	[221,184]	[49,59]	-6	hSpCas9	negative selection	5447628
89984528	89984550	14	-	27760321	MOLM13	viability	AGCAATTCGTGGGTATAAGGGG	TDP1	ENSG00000042088	-1.3609094579012209	[265,222]	[66,41]	-7	hSpCas9	negative selection	5447629
89955933	89955956	14	+	27661255	K562	viability	GCGGGATCCGAGGCAAGCGTTGG	TDP1	ENSG00000042088	0.13830762860788903	[287,368]	[293,281]	5	dCas9-KRAB	negative selection	5516619
89955888	89955911	14	-	27661255	K562	viability	GCGCGCAGTTCAAACCCTGGCGG	TDP1	ENSG00000042088	-0.35072074612933246	[236,217]	[159,127]	-7	dCas9-KRAB	negative selection	5516620
89971179	89971202	14	+	27260156	BXPC3	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.13440288599751915	[302]	[340,310,418,317]	3	hSpCas9	negative selection	5574971
89967366	89967389	14	+	27260156	BXPC3	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.23317596960730988	[408]	[469,488,519,536]	5	hSpCas9	negative selection	5574972
89971245	89971268	14	-	27260156	BXPC3	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.2657137664229771	[276]	[294,415,371,303]	6	hSpCas9	negative selection	5574973
89967401	89967424	14	+	27260156	BXPC3	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.13576492839569154	[485]	[368,461,415,629]	-3	hSpCas9	negative selection	5639225
89966169	89966192	14	+	27260156	BXPC3	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.1494623904176613	[158]	[163,146,170,268]	3	hSpCas9	negative selection	5639226
89966158	89966181	14	-	27260156	BXPC3	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.13506591788717803	[174]	[120,173,139,243]	-3	hSpCas9	negative selection	5639227
89971179	89971202	14	+	27260156	A673	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.30532887336796644	[302]	[547,344,414,506]	7	hSpCas9	negative selection	5696222
89967366	89967389	14	+	27260156	A673	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.025741099924262545	[408]	[496,491,419,523]	0	hSpCas9	negative selection	5696223
89971245	89971268	14	-	27260156	A673	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.20912876265872615	[276]	[390,409,432,297]	5	hSpCas9	negative selection	5696224
89967401	89967424	14	+	27260156	A673	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.17003267588514825	[485]	[513,412,612,535]	-4	hSpCas9	negative selection	5760476
89966169	89966192	14	+	27260156	A673	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.34927677238631794	[158]	[277,200,245,252]	7	hSpCas9	negative selection	5760477
89966158	89966181	14	-	27260156	A673	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.06957780057417762	[174]	[215,245,178,157]	-2	hSpCas9	negative selection	5760478
89971179	89971202	14	+	27260156	A375	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.31502094834237676	[302]	[506,546,338,387]	4	hSpCas9	negative selection	5817473
89967366	89967389	14	+	27260156	A375	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.3745288566670128	[408]	[524,668,805,495]	5	hSpCas9	negative selection	5817474
89971245	89971268	14	-	27260156	A375	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.11950523668736557	[276]	[265,290,463,371]	1	hSpCas9	negative selection	5817475
89967401	89967424	14	+	27260156	A375	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.014080891460519752	[485]	[609,461,764,452]	0	hSpCas9	negative selection	5881727
89966169	89966192	14	+	27260156	A375	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.4852984554528681	[158]	[276,359,239,184]	7	hSpCas9	negative selection	5881728
89966158	89966181	14	-	27260156	A375	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.229857630255766	[174]	[146,229,395,188]	3	hSpCas9	negative selection	5881729
89971179	89971202	14	+	27260156	COLO741	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.35770396400948185	[302]	[573,512,412]	7	hSpCas9	negative selection	5938724
89967366	89967389	14	+	27260156	COLO741	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.045192374143748715	[408]	[552,488,481]	-1	hSpCas9	negative selection	5938725
89971245	89971268	14	-	27260156	COLO741	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.45948284062123035	[276]	[544,421,495]	8	hSpCas9	negative selection	5938726
89967401	89967424	14	+	27260156	COLO741	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.21709680200533524	[485]	[390,669,528]	-5	hSpCas9	negative selection	6002978
89966169	89966192	14	+	27260156	COLO741	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.22725780098644832	[158]	[297,308,119]	5	hSpCas9	negative selection	6002979
89966158	89966181	14	-	27260156	COLO741	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.29633793450447254	[174]	[271,360,195]	6	hSpCas9	negative selection	6002980
89971179	89971202	14	+	27260156	CAL120	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.3557627459467351	[302]	[394,437,598]	5	hSpCas9	negative selection	6059975
89967366	89967389	14	+	27260156	CAL120	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.013964107877704884	[408]	[559,561,427]	0	hSpCas9	negative selection	6059976
89971245	89971268	14	-	27260156	CAL120	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	-0.38707012555941045	[276]	[372,164,268]	-5	hSpCas9	negative selection	6059977
89967401	89967424	14	+	27260156	CAL120	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.09952477544051025	[485]	[558,597,770]	1	hSpCas9	negative selection	6124229
89966169	89966192	14	+	27260156	CAL120	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.738595958118643	[158]	[584,134,308]	9	hSpCas9	negative selection	6124230
89966158	89966181	14	-	27260156	CAL120	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.006786851819625683	[174]	[274,227,156]	0	hSpCas9	negative selection	6124231
89971179	89971202	14	+	27260156	CADOES1	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.04569839813866883	[302]	[315,331,263,249]	0	hSpCas9	negative selection	6181226
89967366	89967389	14	+	27260156	CADOES1	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.3719161754365992	[408]	[198,370,240,367]	-6	hSpCas9	negative selection	6181227
89971245	89971268	14	-	27260156	CADOES1	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	-0.09953590261330081	[276]	[221,190,275,273]	-2	hSpCas9	negative selection	6181228
89967401	89967424	14	+	27260156	CADOES1	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.12173379837707154	[485]	[411,528,381,335]	-2	hSpCas9	negative selection	6245480
89966169	89966192	14	+	27260156	CADOES1	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.5781202569566655	[158]	[268,256,162,192]	8	hSpCas9	negative selection	6245481
89966158	89966181	14	-	27260156	CADOES1	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.3743903648711182	[174]	[157,123,123,94]	-6	hSpCas9	negative selection	6245482
89971179	89971202	14	+	27260156	EWS502	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.7658536982618784	[302]	[474,652,436,623]	9	hSpCas9	negative selection	6302477
89967366	89967389	14	+	27260156	EWS502	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.22339980724503608	[408]	[383,553,511,589]	4	hSpCas9	negative selection	6302478
89971245	89971268	14	-	27260156	EWS502	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.15279629964192343	[276]	[211,359,437,305]	2	hSpCas9	negative selection	6302479
89967401	89967424	14	+	27260156	EWS502	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.38437654660580317	[485]	[367,305,345,574]	-6	hSpCas9	negative selection	6366731
89966169	89966192	14	+	27260156	EWS502	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.5004996975389333	[158]	[197,272,288,192]	8	hSpCas9	negative selection	6366732
89966158	89966181	14	-	27260156	EWS502	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.3829482921838365	[174]	[90,216,166,92]	-6	hSpCas9	negative selection	6366733
89971179	89971202	14	+	27260156	EW8	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.04555740461313318	[302]	[400,180,229,220]	0	hSpCas9	negative selection	6423728
89967366	89967389	14	+	27260156	EW8	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.014237589462685357	[408]	[321,410,314,265]	0	hSpCas9	negative selection	6423729
89971245	89971268	14	-	27260156	EW8	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.2572058731559411	[276]	[309,247,219,306]	5	hSpCas9	negative selection	6423730
89967401	89967424	14	+	27260156	EW8	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.19038983594513637	[485]	[498,358,255,297]	-4	hSpCas9	negative selection	6487982
89966169	89966192	14	+	27260156	EW8	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.26632162960914885	[158]	[161,164,108,191]	5	hSpCas9	negative selection	6487983
89966158	89966181	14	-	27260156	EW8	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.2110328905697949	[174]	[245,150,111,164]	4	hSpCas9	negative selection	6487984
89971179	89971202	14	+	27260156	CORL105	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.6470303499149289	[302]	[437,652,663,477]	9	hSpCas9	negative selection	6544979
89967366	89967389	14	+	27260156	CORL105	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.2542579741890227	[408]	[385,328,437,458]	-5	hSpCas9	negative selection	6544980
89971245	89971268	14	-	27260156	CORL105	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	-0.016024037049905737	[276]	[329,392,189,347]	0	hSpCas9	negative selection	6544981
89967401	89967424	14	+	27260156	CORL105	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.0062357962317487955	[485]	[371,449,935,579]	0	hSpCas9	negative selection	6609233
89966169	89966192	14	+	27260156	CORL105	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.21897396272111802	[158]	[237,246,254,132]	4	hSpCas9	negative selection	6609234
89966158	89966181	14	-	27260156	CORL105	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.1509709698695305	[174]	[229,164,202,144]	-3	hSpCas9	negative selection	6609235
89971179	89971202	14	+	27260156	HS294T	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.7851567080828353	[302]	[174,221,128,298]	8	hSpCas9	negative selection	6666230
89967366	89967389	14	+	27260156	HS294T	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.031193459084124242	[408]	[117,117,266,145]	0	hSpCas9	negative selection	6666231
89971245	89971268	14	-	27260156	HS294T	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	-0.16952728479055046	[276]	[105,46,93,141]	-2	hSpCas9	negative selection	6666232
89967401	89967424	14	+	27260156	HS294T	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.05070066591868576	[485]	[188,203,170,217]	0	hSpCas9	negative selection	6730484
89966169	89966192	14	+	27260156	HS294T	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	-0.4001689593000861	[158]	[50,26,63,43]	-5	hSpCas9	negative selection	6730485
89966158	89966181	14	-	27260156	HS294T	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.8930095376239731	[174]	[152,74,78,207]	9	hSpCas9	negative selection	6730486
89971179	89971202	14	+	27260156	HCC44	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.5253825785231486	[302]	[710,429,432,415]	8	hSpCas9	negative selection	6787481
89967366	89967389	14	+	27260156	HCC44	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.051810701674217086	[408]	[574,226,883,346]	0	hSpCas9	negative selection	6787482
89971245	89971268	14	-	27260156	HCC44	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.42575889812507994	[276]	[378,494,550,267]	7	hSpCas9	negative selection	6787483
89967401	89967424	14	+	27260156	HCC44	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.13098214908023248	[485]	[381,342,1012,369]	-2	hSpCas9	negative selection	6851735
89966169	89966192	14	+	27260156	HCC44	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.4394171997842269	[158]	[199,165,296,323]	7	hSpCas9	negative selection	6851736
89966158	89966181	14	-	27260156	HCC44	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.2909571137334348	[174]	[272,124,125,131]	-4	hSpCas9	negative selection	6851737
89971179	89971202	14	+	27260156	G402	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.4627319787036453	[302]	[737,582,530,234]	6	hSpCas9	negative selection	6908732
89967366	89967389	14	+	27260156	G402	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.2756326176225554	[408]	[903,550,577,429]	3	hSpCas9	negative selection	6908733
89971245	89971268	14	-	27260156	G402	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	-0.3862244554900347	[276]	[119,108,416,353]	-5	hSpCas9	negative selection	6908734
89967401	89967424	14	+	27260156	G402	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.02874749070912512	[485]	[394,441,751,779]	0	hSpCas9	negative selection	6972986
89966169	89966192	14	+	27260156	G402	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.49495916936469486	[158]	[492,186,307,137]	6	hSpCas9	negative selection	6972987
89966158	89966181	14	-	27260156	G402	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.24897920949561536	[174]	[144,207,124,233]	-3	hSpCas9	negative selection	6972988
89971179	89971202	14	+	27260156	L33	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.3652571858346243	[302]	[410,181,220,353]	7	hSpCas9	negative selection	7029983
89967366	89967389	14	+	27260156	L33	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.11577323470632528	[408]	[323,124,262,462]	-3	hSpCas9	negative selection	7029984
89971245	89971268	14	-	27260156	L33	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.17438501320158406	[276]	[333,156,168,263]	4	hSpCas9	negative selection	7029985
89967401	89967424	14	+	27260156	L33	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.15730405663529623	[485]	[497,236,354,527]	3	hSpCas9	negative selection	7094237
89966169	89966192	14	+	27260156	L33	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.20399393885551098	[158]	[144,51,103,294]	4	hSpCas9	negative selection	7094238
89966158	89966181	14	-	27260156	L33	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.09918533668806617	[174]	[151,62,183,152]	2	hSpCas9	negative selection	7094239
89971179	89971202	14	+	27260156	K562	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.2398698430673601	[302]	[453,556,128,169]	3	hSpCas9	negative selection	7151234
89967366	89967389	14	+	27260156	K562	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.13132976466764076	[408]	[252,260,558,485]	1	hSpCas9	negative selection	7151235
89971245	89971268	14	-	27260156	K562	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	-0.020276386833783078	[276]	[422,244,134,186]	0	hSpCas9	negative selection	7151236
89967401	89967424	14	+	27260156	K562	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.608199615545403	[485]	[754,928,371,599]	7	hSpCas9	negative selection	7215488
89966169	89966192	14	+	27260156	K562	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.3267559281532031	[158]	[374,118,140,94]	4	hSpCas9	negative selection	7215489
89966158	89966181	14	-	27260156	K562	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.6334190563369757	[174]	[89,176,307,357]	7	hSpCas9	negative selection	7215490
89971179	89971202	14	+	27260156	HT29	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.4687671274323926	[302]	[646,489,548,374]	8	hSpCas9	negative selection	7272485
89967366	89967389	14	+	27260156	HT29	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.12048980840567931	[408]	[554,681,498,446]	2	hSpCas9	negative selection	7272486
89971245	89971268	14	-	27260156	HT29	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.2533386252299916	[276]	[479,406,409,321]	5	hSpCas9	negative selection	7272487
89967401	89967424	14	+	27260156	HT29	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.16755703254426152	[485]	[742,702,523,685]	3	hSpCas9	negative selection	7336739
89966169	89966192	14	+	27260156	HT29	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.21487878122789916	[158]	[237,254,169,234]	4	hSpCas9	negative selection	7336740
89966158	89966181	14	-	27260156	HT29	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.35902947564537824	[174]	[178,272,274,345]	7	hSpCas9	negative selection	7336741
89971179	89971202	14	+	27260156	MHHES1	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.2312412002580454	[302]	[500,347,286,450]	4	hSpCas9	negative selection	7393736
89967366	89967389	14	+	27260156	MHHES1	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.18438703610969576	[408]	[495,410,487,262]	-3	hSpCas9	negative selection	7393737
89971245	89971268	14	-	27260156	MHHES1	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.4861676010805236	[276]	[423,481,470,377]	8	hSpCas9	negative selection	7393738
89967401	89967424	14	+	27260156	MHHES1	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.040493744120962176	[485]	[555,502,725,370]	0	hSpCas9	negative selection	7457990
89966169	89966192	14	+	27260156	MHHES1	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.07016527696514774	[158]	[310,191,105,159]	1	hSpCas9	negative selection	7457991
89966158	89966181	14	-	27260156	MHHES1	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.016708603062862037	[174]	[143,335,211,110]	0	hSpCas9	negative selection	7457992
89971179	89971202	14	+	27260156	MEWO	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.2821235620164079	[302]	[457,339,257]	6	hSpCas9	negative selection	7514987
89967366	89967389	14	+	27260156	MEWO	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.5295367245761249	[408]	[606,443,616]	9	hSpCas9	negative selection	7514988
89971245	89971268	14	-	27260156	MEWO	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.20953838177910578	[276]	[372,324,214]	4	hSpCas9	negative selection	7514989
89967401	89967424	14	+	27260156	MEWO	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.3045454840858945	[485]	[356,413,330]	-6	hSpCas9	negative selection	7579241
89966169	89966192	14	+	27260156	MEWO	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.04753843220925624	[158]	[198,142,127]	1	hSpCas9	negative selection	7579242
89966158	89966181	14	-	27260156	MEWO	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.2831474900555926	[174]	[213,95,290]	6	hSpCas9	negative selection	7579243
89971179	89971202	14	+	27260156	LNCAPCLONEFGC	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.20382322933259034	[302]	[338,300,296,324]	3	hSpCas9	negative selection	7636238
89967366	89967389	14	+	27260156	LNCAPCLONEFGC	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.12741907765215893	[408]	[341,249,363,409]	-2	hSpCas9	negative selection	7636239
89971245	89971268	14	-	27260156	LNCAPCLONEFGC	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	-0.05602679574429881	[276]	[291,196,232,243]	-1	hSpCas9	negative selection	7636240
89967401	89967424	14	+	27260156	LNCAPCLONEFGC	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.23628875952097406	[485]	[391,265,619,259]	-4	hSpCas9	negative selection	7700492
89966169	89966192	14	+	27260156	LNCAPCLONEFGC	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.3535314538592873	[158]	[214,179,145,188]	5	hSpCas9	negative selection	7700493
89966158	89966181	14	-	27260156	LNCAPCLONEFGC	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.08785808274183804	[174]	[135,177,122,153]	-1	hSpCas9	negative selection	7700494
89971179	89971202	14	+	27260156	PANC0327	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.2373831882996314	[302]	[430,152,498,216]	3	hSpCas9	negative selection	7757489
89967366	89967389	14	+	27260156	PANC0327	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.4969120669588694	[408]	[219,154,342,321]	-6	hSpCas9	negative selection	7757490
89971245	89971268	14	-	27260156	PANC0327	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.6369482633684019	[276]	[458,262,346,482]	8	hSpCas9	negative selection	7757491
89967401	89967424	14	+	27260156	PANC0327	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.44992165898693914	[485]	[296,1033,391,553]	6	hSpCas9	negative selection	7821743
89966169	89966192	14	+	27260156	PANC0327	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.23681019432776407	[158]	[287,109,174,109]	3	hSpCas9	negative selection	7821744
89966158	89966181	14	-	27260156	PANC0327	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-1.03658357748745	[174]	[120,50,68,68]	-8	hSpCas9	negative selection	7821745
89971179	89971202	14	+	27260156	NCIH2009	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.8591015447977904	[302]	[832,781,699]	9	hSpCas9	negative selection	7878740
89967366	89967389	14	+	27260156	NCIH2009	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.2425793214932606	[408]	[726,517,794]	3	hSpCas9	negative selection	7878741
89971245	89971268	14	-	27260156	NCIH2009	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.3017305440228221	[276]	[520,476,440]	4	hSpCas9	negative selection	7878742
89967401	89967424	14	+	27260156	NCIH2009	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.010924912275108306	[485]	[830,871,344]	0	hSpCas9	negative selection	7942994
89966169	89966192	14	+	27260156	NCIH2009	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	-0.23333415900533883	[158]	[114,297,136]	-3	hSpCas9	negative selection	7942995
89966158	89966181	14	-	27260156	NCIH2009	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.162891541208664	[174]	[445,260,147]	2	hSpCas9	negative selection	7942996
89971179	89971202	14	+	27260156	NCIH1373	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.791875479098977	[302]	[465,366,573,254]	7	hSpCas9	negative selection	7999991
89967366	89967389	14	+	27260156	NCIH1373	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.2230414400903234	[408]	[579,242,943,102]	2	hSpCas9	negative selection	7999992
89971245	89971268	14	-	27260156	NCIH1373	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.20471829861757984	[276]	[756,177,364,52]	2	hSpCas9	negative selection	7999993
89967401	89967424	14	+	27260156	NCIH1373	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.29216682790055226	[485]	[357,884,451,240]	3	hSpCas9	negative selection	8064245
89966169	89966192	14	+	27260156	NCIH1373	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	-0.7111648813105345	[158]	[124,78,111,32]	-6	hSpCas9	negative selection	8064246
89966158	89966181	14	-	27260156	NCIH1373	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.44433284878851265	[174]	[518,226,226,33]	4	hSpCas9	negative selection	8064247
89971179	89971202	14	+	27260156	PATU8902	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.4048743981981474	[302]	[652,719,224,739]	4	hSpCas9	negative selection	8121242
89967366	89967389	14	+	27260156	PATU8902	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.6341178770339834	[408]	[911,879,536,1344]	6	hSpCas9	negative selection	8121243
89971245	89971268	14	-	27260156	PATU8902	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.6852864090606468	[276]	[518,938,489,556]	7	hSpCas9	negative selection	8121244
89967401	89967424	14	+	27260156	PATU8902	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.2827386924599419	[485]	[788,963,629,972]	3	hSpCas9	negative selection	8185496
89966169	89966192	14	+	27260156	PATU8902	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.48644124907190056	[158]	[332,204,81,726]	5	hSpCas9	negative selection	8185497
89966158	89966181	14	-	27260156	PATU8902	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.3642489420597228	[174]	[400,199,280,385]	4	hSpCas9	negative selection	8185498
89971179	89971202	14	+	27260156	PANC1	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.42495397911800203	[302]	[292,626,353,200]	7	hSpCas9	negative selection	8242493
89967366	89967389	14	+	27260156	PANC1	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.22621290996652116	[408]	[319,315,376,202]	-4	hSpCas9	negative selection	8242494
89971245	89971268	14	-	27260156	PANC1	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.051141613485874204	[276]	[280,315,219,187]	0	hSpCas9	negative selection	8242495
89967401	89967424	14	+	27260156	PANC1	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.26082488646950225	[485]	[330,467,297,319]	-4	hSpCas9	negative selection	8306747
89966169	89966192	14	+	27260156	PANC1	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.21547836861528724	[158]	[165,59,109,257]	3	hSpCas9	negative selection	8306748
89966158	89966181	14	-	27260156	PANC1	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.06463294000040065	[174]	[96,168,149,159]	-1	hSpCas9	negative selection	8306749
89971179	89971202	14	+	27260156	PANC0813	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.42453694028679523	[302]	[626,480,455,365]	6	hSpCas9	negative selection	8363744
89967366	89967389	14	+	27260156	PANC0813	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.5071743458896926	[408]	[751,876,540,571]	7	hSpCas9	negative selection	8363745
89971245	89971268	14	-	27260156	PANC0813	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.25072791704170794	[276]	[486,345,406,320]	4	hSpCas9	negative selection	8363746
89967401	89967424	14	+	27260156	PANC0813	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.2840081572219148	[485]	[789,951,552,502]	4	hSpCas9	negative selection	8427998
89966169	89966192	14	+	27260156	PANC0813	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	-0.5689906994480749	[158]	[97,208,110,84]	-7	hSpCas9	negative selection	8427999
89966158	89966181	14	-	27260156	PANC0813	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.36412440511419963	[174]	[182,90,172,191]	-5	hSpCas9	negative selection	8428000
89971179	89971202	14	+	27260156	RDES	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.4539232262266262	[302]	[325,474,595,546]	7	hSpCas9	negative selection	8484995
89967366	89967389	14	+	27260156	RDES	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.2322569186000828	[408]	[438,572,636,572]	4	hSpCas9	negative selection	8484996
89971245	89971268	14	-	27260156	RDES	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.177933746479793	[276]	[340,383,340,364]	3	hSpCas9	negative selection	8484997
89967401	89967424	14	+	27260156	RDES	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.04465464544366805	[485]	[342,593,624,647]	0	hSpCas9	negative selection	8549249
89966169	89966192	14	+	27260156	RDES	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.648123950892059	[158]	[259,205,279,425]	9	hSpCas9	negative selection	8549250
89966158	89966181	14	-	27260156	RDES	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.32827241046748523	[174]	[114,254,371,304]	5	hSpCas9	negative selection	8549251
89971179	89971202	14	+	27260156	PC3	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	-0.06908495985497931	[302]	[140,285,422,400]	-1	hSpCas9	negative selection	8606246
89967366	89967389	14	+	27260156	PC3	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.2427689811734788	[408]	[309,417,878,509]	5	hSpCas9	negative selection	8606247
89971245	89971268	14	-	27260156	PC3	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.32110934900653404	[276]	[225,384,443,378]	7	hSpCas9	negative selection	8606248
89967401	89967424	14	+	27260156	PC3	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.001230219026275653	[485]	[232,611,723,529]	0	hSpCas9	negative selection	8670500
89966169	89966192	14	+	27260156	PC3	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	-0.19915586667735896	[158]	[133,120,151,132]	-4	hSpCas9	negative selection	8670501
89966158	89966181	14	-	27260156	PC3	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.1805897725720811	[174]	[101,253,248,228]	4	hSpCas9	negative selection	8670502
89971179	89971202	14	+	27260156	PATU8988T	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.28354306385491507	[302]	[354,340,300,433]	5	hSpCas9	negative selection	8727497
89967366	89967389	14	+	27260156	PATU8988T	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.007874833496284983	[408]	[424,250,366,526]	0	hSpCas9	negative selection	8727498
89971245	89971268	14	-	27260156	PATU8988T	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.2986771025653978	[276]	[156,331,474,352]	5	hSpCas9	negative selection	8727499
89967401	89967424	14	+	27260156	PATU8988T	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.42235791234639897	[485]	[343,521,249,298]	-6	hSpCas9	negative selection	8791751
89966169	89966192	14	+	27260156	PATU8988T	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.8798500599038596	[158]	[178,301,391,255]	9	hSpCas9	negative selection	8791752
89966158	89966181	14	-	27260156	PATU8988T	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.565501379812558	[174]	[285,538,113,76]	8	hSpCas9	negative selection	8791753
89971179	89971202	14	+	27260156	T47D	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.20573484893480848	[302]	[421,362,492,350]	4	hSpCas9	negative selection	8848748
89967366	89967389	14	+	27260156	T47D	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.04491380118053204	[408]	[534,508,348,451]	-1	hSpCas9	negative selection	8848749
89971245	89971268	14	-	27260156	T47D	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.24407573114709902	[276]	[337,371,404,414]	5	hSpCas9	negative selection	8848750
89967401	89967424	14	+	27260156	T47D	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.11502554786354562	[485]	[570,535,420,564]	-3	hSpCas9	negative selection	8913002
89966169	89966192	14	+	27260156	T47D	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.31103541234388876	[158]	[265,141,267,250]	6	hSpCas9	negative selection	8913003
89966158	89966181	14	-	27260156	T47D	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.1949010740348165	[174]	[227,247,186,270]	4	hSpCas9	negative selection	8913004
89971179	89971202	14	+	27260156	SU8686	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.5007530123564137	[302]	[374,360,327,686]	8	hSpCas9	negative selection	8969999
89967366	89967389	14	+	27260156	SU8686	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.234652575128453	[408]	[428,412,467,633]	4	hSpCas9	negative selection	8970000
89971245	89971268	14	-	27260156	SU8686	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.044774677659777384	[276]	[218,255,347,327]	0	hSpCas9	negative selection	8970001
89967401	89967424	14	+	27260156	SU8686	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.069778092796506	[485]	[463,393,562,640]	1	hSpCas9	negative selection	9034253
89966169	89966192	14	+	27260156	SU8686	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.302111877823823	[158]	[120,150,244,289]	5	hSpCas9	negative selection	9034254
89966158	89966181	14	-	27260156	SU8686	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	-0.9906580270039644	[174]	[79,71,63,143]	-8	hSpCas9	negative selection	9034255
89971179	89971202	14	+	27260156	SKES1	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.43701135662210056	[302]	[249,595,271,504]	8	hSpCas9	negative selection	9091250
89967366	89967389	14	+	27260156	SKES1	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.20791795719442155	[408]	[539,511,489,364]	4	hSpCas9	negative selection	9091251
89971245	89971268	14	-	27260156	SKES1	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.20291022039738338	[276]	[171,385,401,297]	4	hSpCas9	negative selection	9091252
89967401	89967424	14	+	27260156	SKES1	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.0353453559585664	[485]	[516,478,554,437]	0	hSpCas9	negative selection	9155504
89966169	89966192	14	+	27260156	SKES1	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.43199994749635473	[158]	[175,306,191,187]	8	hSpCas9	negative selection	9155505
89966158	89966181	14	-	27260156	SKES1	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.3698807511723714	[174]	[225,236,248,192]	7	hSpCas9	negative selection	9155506
89971179	89971202	14	+	27260156	TOV112D	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	-0.021508733273523317	[302]	[189,354,209,440]	0	hSpCas9	negative selection	9212501
89967366	89967389	14	+	27260156	TOV112D	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.4261991448897183	[408]	[410,331,311,182]	-7	hSpCas9	negative selection	9212502
89971245	89971268	14	-	27260156	TOV112D	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.23127523049472354	[276]	[389,578,187,215]	4	hSpCas9	negative selection	9212503
89967401	89967424	14	+	27260156	TOV112D	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.2706019414712546	[485]	[382,628,355,301]	-5	hSpCas9	negative selection	9276755
89966169	89966192	14	+	27260156	TOV112D	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	-0.023536811755252796	[158]	[111,175,203,135]	0	hSpCas9	negative selection	9276756
89966158	89966181	14	-	27260156	TOV112D	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.09396088756583487	[174]	[131,272,82,273]	1	hSpCas9	negative selection	9276757
89971179	89971202	14	+	27260156	TC71	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.16951278165580969	[302]	[253,427,374,408]	4	hSpCas9	negative selection	9333752
89967366	89967389	14	+	27260156	TC71	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	0.1487925549268321	[408]	[458,469,402,623]	4	hSpCas9	negative selection	9333753
89971245	89971268	14	-	27260156	TC71	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.32219623942698405	[276]	[372,299,394,418]	7	hSpCas9	negative selection	9333754
89967401	89967424	14	+	27260156	TC71	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	-0.08687437428320205	[485]	[453,498,467,545]	-2	hSpCas9	negative selection	9398006
89966169	89966192	14	+	27260156	TC71	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	-0.06618427560910334	[158]	[104,142,188,217]	-2	hSpCas9	negative selection	9398007
89966158	89966181	14	-	27260156	TC71	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.20253284808338612	[174]	[269,117,205,271]	5	hSpCas9	negative selection	9398008
89971179	89971202	14	+	27260156	TC32	viability	AAGCCAATCCTGCTTGTGCATGG	TDP1	ENSG00000042088	0.1270942553033645	[302]	[242,297,412,300]	2	hSpCas9	negative selection	9455003
89967366	89967389	14	+	27260156	TC32	viability	GTTTAACTACTGCTTTGACGTGG	TDP1	ENSG00000042088	-0.18482221682958755	[408]	[417,239,340,360]	-3	hSpCas9	negative selection	9455004
89971245	89971268	14	-	27260156	TC32	viability	CAGAGAGAGATGTTCTCGTAAGG	TDP1	ENSG00000042088	0.10194243543817105	[276]	[305,299,215,251]	1	hSpCas9	negative selection	9455005
89967401	89967424	14	+	27260156	TC32	viability	AACAGTATCCACCAGAGTTCAGG	TDP1	ENSG00000042088	0.06734856770945122	[485]	[373,539,510,450]	1	hSpCas9	negative selection	9519257
89966169	89966192	14	+	27260156	TC32	viability	GACGCTTGTTTCTTCAGCTCAGG	TDP1	ENSG00000042088	0.2545348038029198	[158]	[179,144,192,199]	4	hSpCas9	negative selection	9519258
89966158	89966181	14	-	27260156	TC32	viability	GAAACAAGCGTCCCAAATAAAGG	TDP1	ENSG00000042088	0.3298078229537176	[174]	[275,107,312,161]	6	hSpCas9	negative selection	9519259
89963122	89963145	14	+	27869803	HPAFII	viability after 27 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.3249159519210883	[204]	[146,124,NaN]	2	hSpCas9	negative selection	9552681
89967371	89967394	14	+	27869803	HPAFII	viability after 27 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	1.4260847761718622	[86]	[219,41,NaN]	9	hSpCas9	negative selection	9552682
89971229	89971252	14	-	27869803	HPAFII	viability after 27 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.7263395882231699	[316]	[272,277,NaN]	6	hSpCas9	negative selection	9552683
89980573	89980596	14	-	27869803	HPAFII	viability after 27 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.6363565473208986	[466]	[547,242,NaN]	5	hSpCas9	negative selection	9552684
89984627	89984650	14	-	27869803	HPAFII	viability after 27 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.5985548078956874	[476]	[532,251,NaN]	5	hSpCas9	negative selection	9552685
89988916	89988939	14	-	27869803	HPAFII	viability after 27 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	1.1092150116719206	[558]	[861,443,NaN]	8	hSpCas9	negative selection	9552686
89963122	89963145	14	+	27869803	HPAFII	viability after 15 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-0.11102904128811869	[204]	[203,203,NaN]	-1	hSpCas9	negative selection	9635130
89967371	89967394	14	+	27869803	HPAFII	viability after 15 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	0.8433195516699995	[86]	[250,115,NaN]	8	hSpCas9	negative selection	9635131
89971229	89971252	14	-	27869803	HPAFII	viability after 15 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.5169189516227579	[316]	[394,544,NaN]	6	hSpCas9	negative selection	9635132
89980573	89980596	14	-	27869803	HPAFII	viability after 15 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.24405271977675247	[466]	[1009,335,NaN]	3	hSpCas9	negative selection	9635133
89984627	89984650	14	-	27869803	HPAFII	viability after 15 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.046320495719657795	[476]	[767,380,NaN]	0	hSpCas9	negative selection	9635134
89988916	89988939	14	-	27869803	HPAFII	viability after 15 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.5708468102412527	[558]	[1278,651,NaN]	6	hSpCas9	negative selection	9635135
89963122	89963145	14	+	27869803	ASPC1	viability after 36 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.42032676629458066	[603]	[155,442,239]	4	hSpCas9	negative selection	9717579
89967371	89967394	14	+	27869803	ASPC1	viability after 36 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	1.346037750262513	[327]	[595,139,193]	9	hSpCas9	negative selection	9717580
89971229	89971252	14	-	27869803	ASPC1	viability after 36 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.18396741334204814	[1029]	[334,402,459]	1	hSpCas9	negative selection	9717581
89980573	89980596	14	-	27869803	ASPC1	viability after 36 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.46406531751177404	[1017]	[535,547,406]	4	hSpCas9	negative selection	9717582
89984627	89984650	14	-	27869803	ASPC1	viability after 36 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.8401097325722168	[946]	[457,517,737]	7	hSpCas9	negative selection	9717583
89988916	89988939	14	-	27869803	ASPC1	viability after 36 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	0.7557219320273851	[1346]	[954,611,816]	7	hSpCas9	negative selection	9717584
89963122	89963145	14	+	27869803	PATU8988S	viability after 35 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.2466424250192898	[573]	[177,370,NaN]	3	hSpCas9	negative selection	9800028
89967371	89967394	14	+	27869803	PATU8988S	viability after 35 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	0.10763375432847816	[361]	[195,117,NaN]	1	hSpCas9	negative selection	9800029
89971229	89971252	14	-	27869803	PATU8988S	viability after 35 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	-0.23218243515522774	[907]	[238,383,NaN]	-2	hSpCas9	negative selection	9800030
89980573	89980596	14	-	27869803	PATU8988S	viability after 35 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.6492505828495797	[964]	[629,588,NaN]	7	hSpCas9	negative selection	9800031
89984627	89984650	14	-	27869803	PATU8988S	viability after 35 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	-0.10695371827388833	[833]	[264,358,NaN]	-1	hSpCas9	negative selection	9800032
89988916	89988939	14	-	27869803	PATU8988S	viability after 35 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	1.1706801368922992	[967]	[1161,591,NaN]	9	hSpCas9	negative selection	9800033
89963122	89963145	14	+	27869803	PATU8988S	viability after 31 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	-0.011992132172486125	[573]	[149,324,NaN]	0	hSpCas9	negative selection	9882477
89967371	89967394	14	+	27869803	PATU8988S	viability after 31 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	-0.1765257531805693	[361]	[132,120,NaN]	-2	hSpCas9	negative selection	9882478
89971229	89971252	14	-	27869803	PATU8988S	viability after 31 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.08705199645780504	[907]	[278,518,NaN]	1	hSpCas9	negative selection	9882479
89980573	89980596	14	-	27869803	PATU8988S	viability after 31 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.6852380312838228	[964]	[645,583,NaN]	7	hSpCas9	negative selection	9882480
89984627	89984650	14	-	27869803	PATU8988S	viability after 31 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.0805818870863626	[833]	[231,503,NaN]	1	hSpCas9	negative selection	9882481
89988916	89988939	14	-	27869803	PATU8988S	viability after 31 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	1.045805883335925	[967]	[751,853,NaN]	9	hSpCas9	negative selection	9882482
89963122	89963145	14	+	27869803	HPAFII	viability after 35 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.6475183301846634	[204]	[123,205,NaN]	4	hSpCas9	negative selection	9964926
89967371	89967394	14	+	27869803	HPAFII	viability after 35 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	2.6980191346544027	[86]	[480,65,NaN]	9	hSpCas9	negative selection	9964927
89971229	89971252	14	-	27869803	HPAFII	viability after 35 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.17501242562423136	[316]	[64,311,NaN]	1	hSpCas9	negative selection	9964928
89980573	89980596	14	-	27869803	HPAFII	viability after 35 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.7537107124067634	[466]	[479,306,NaN]	5	hSpCas9	negative selection	9964929
89984627	89984650	14	-	27869803	HPAFII	viability after 35 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.22587572135302325	[476]	[391,158,NaN]	1	hSpCas9	negative selection	9964930
89988916	89988939	14	-	27869803	HPAFII	viability after 35 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	1.6496265537617503	[558]	[1147,594,NaN]	9	hSpCas9	negative selection	9964931
89963122	89963145	14	+	27869803	HPAFII	viability after 31 days	AGGAAGGCGATTATGGGAGGTGG	TDP1	ENSG00000042088	0.817296718431276	[204]	[218,184,NaN]	6	hSpCas9	negative selection	10047375
89967371	89967394	14	+	27869803	HPAFII	viability after 31 days	ACTACTGCTTTGACGTGGACTGG	TDP1	ENSG00000042088	2.5081079063211997	[86]	[450,88,NaN]	9	hSpCas9	negative selection	10047376
89971229	89971252	14	-	27869803	HPAFII	viability after 31 days	CGTAAGGCTTGGCCTGGGCATGG	TDP1	ENSG00000042088	0.311721870477632	[316]	[104,346,NaN]	2	hSpCas9	negative selection	10047377
89980573	89980596	14	-	27869803	HPAFII	viability after 31 days	TGGAGGTGTGTATGACAACCCGG	TDP1	ENSG00000042088	0.5889287080996876	[466]	[398,388,NaN]	4	hSpCas9	negative selection	10047378
89984627	89984650	14	-	27869803	HPAFII	viability after 31 days	CTATCCACTCCTTGAGAGAAGGG	TDP1	ENSG00000042088	0.22755150983215444	[476]	[378,241,NaN]	1	hSpCas9	negative selection	10047379
89988916	89988939	14	-	27869803	HPAFII	viability after 31 days	CGTTAGGCATGGATGAGGCATGG	TDP1	ENSG00000042088	1.1976464993863782	[558]	[921,498,NaN]	8	hSpCas9	negative selection	10047380
89963227	89963250	14	+	28162770	P31FUJ	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	-1.0807991109693287	[116]	[64]	-6	hSpCas9	negative selection	10248836
89980610	89980633	14	+	28162770	P31FUJ	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	0.2784506101237685	[86]	[123]	3	hSpCas9	negative selection	10248837
89963543	89963566	14	+	28162770	P31FUJ	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	0.5146557635694698	[136]	[229]	6	hSpCas9	negative selection	10248838
89980570	89980593	14	-	28162770	P31FUJ	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	1.021439082961409	[95]	[228]	9	hSpCas9	negative selection	10248839
89989027	89989050	14	+	28162770	P31FUJ	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	0.7587855557694212	[171]	[341]	8	hSpCas9	negative selection	10248840
89993400	89993423	14	-	28162770	P31FUJ	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	-0.05047218208128576	[192]	[218]	0	hSpCas9	negative selection	10248841
90019376	90019399	14	-	28162770	P31FUJ	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	0.7306719195605071	[119]	[233]	8	hSpCas9	negative selection	10248842
89963342	89963365	14	+	28162770	P31FUJ	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	0.485784860436973	[315]	[519]	5	hSpCas9	negative selection	10248843
89963663	89963686	14	-	28162770	P31FUJ	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	-0.1393233045564417	[731]	[780]	-1	hSpCas9	negative selection	10248844
89980597	89980620	14	-	28162770	P31FUJ	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	0.9845546270247709	[122]	[285]	9	hSpCas9	negative selection	10248845
89963227	89963250	14	+	28162770	TF1	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	NaN	[NaN]	[28]	1	hSpCas9	negative selection	10418202
89980610	89980633	14	+	28162770	TF1	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	NaN	[NaN]	[116]	1	hSpCas9	negative selection	10418203
89963543	89963566	14	+	28162770	TF1	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	NaN	[NaN]	[140]	1	hSpCas9	negative selection	10418204
89980570	89980593	14	-	28162770	TF1	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	NaN	[NaN]	[2]	1	hSpCas9	negative selection	10418205
89989027	89989050	14	+	28162770	TF1	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	NaN	[NaN]	[202]	1	hSpCas9	negative selection	10418206
89993400	89993423	14	-	28162770	TF1	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	NaN	[NaN]	[89]	1	hSpCas9	negative selection	10418207
90019376	90019399	14	-	28162770	TF1	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	NaN	[NaN]	[109]	1	hSpCas9	negative selection	10418208
89963342	89963365	14	+	28162770	TF1	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	NaN	[NaN]	[273]	1	hSpCas9	negative selection	10418209
89963663	89963686	14	-	28162770	TF1	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	NaN	[NaN]	[483]	1	hSpCas9	negative selection	10418210
89980597	89980620	14	-	28162770	TF1	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	NaN	[NaN]	[97]	1	hSpCas9	negative selection	10418211
89963227	89963250	14	+	28162770	SKM1	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	-0.48096478018693867	[29]	[37]	-4	hSpCas9	negative selection	10587568
89980610	89980633	14	+	28162770	SKM1	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	0.3530850085360857	[30]	[69]	3	hSpCas9	negative selection	10587569
89963543	89963566	14	+	28162770	SKM1	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	-0.5957258421983294	[52]	[61]	-5	hSpCas9	negative selection	10587570
89980570	89980593	14	-	28162770	SKM1	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.2914869813232256	[35]	[51]	-2	hSpCas9	negative selection	10587571
89989027	89989050	14	+	28162770	SKM1	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	0.44103270781178844	[59]	[143]	4	hSpCas9	negative selection	10587572
89993400	89993423	14	-	28162770	SKM1	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	0.3808151849776816	[52]	[121]	3	hSpCas9	negative selection	10587573
90019376	90019399	14	-	28162770	SKM1	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	-0.0003389392805181468	[42]	[75]	0	hSpCas9	negative selection	10587574
89963342	89963365	14	+	28162770	SKM1	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	0.17799830197799454	[76]	[153]	1	hSpCas9	negative selection	10587575
89963663	89963686	14	-	28162770	SKM1	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	0.5349328466932699	[113]	[291]	5	hSpCas9	negative selection	10587576
89980597	89980620	14	-	28162770	SKM1	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	0.6305105066755012	[37]	[103]	6	hSpCas9	negative selection	10587577
89963227	89963250	14	+	28162770	SKM1	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	-0.48096478018693867	[29]	[37]	-4	hSpCas9	negative selection	10756934
89980610	89980633	14	+	28162770	SKM1	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	0.3530850085360857	[30]	[69]	3	hSpCas9	negative selection	10756935
89963543	89963566	14	+	28162770	SKM1	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	-0.5957258421983294	[52]	[61]	-5	hSpCas9	negative selection	10756936
89980570	89980593	14	-	28162770	SKM1	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.2914869813232256	[35]	[51]	-2	hSpCas9	negative selection	10756937
89989027	89989050	14	+	28162770	SKM1	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	0.44103270781178844	[59]	[143]	4	hSpCas9	negative selection	10756938
89993400	89993423	14	-	28162770	SKM1	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	0.3808151849776816	[52]	[121]	3	hSpCas9	negative selection	10756939
90019376	90019399	14	-	28162770	SKM1	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	-0.0003389392805181468	[42]	[75]	0	hSpCas9	negative selection	10756940
89963342	89963365	14	+	28162770	SKM1	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	0.17799830197799454	[76]	[153]	1	hSpCas9	negative selection	10756941
89963663	89963686	14	-	28162770	SKM1	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	0.5349328466932699	[113]	[291]	5	hSpCas9	negative selection	10756942
89980597	89980620	14	-	28162770	SKM1	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	0.6305105066755012	[37]	[103]	6	hSpCas9	negative selection	10756943
89963227	89963250	14	+	28162770	PL21	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	0.32567049657317904	[120]	[65]	3	hSpCas9	negative selection	10926300
89980610	89980633	14	+	28162770	PL21	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	0.5721083918762782	[67]	[43]	5	hSpCas9	negative selection	10926301
89963543	89963566	14	+	28162770	PL21	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	-0.4548703837600926	[210]	[66]	-3	hSpCas9	negative selection	10926302
89980570	89980593	14	-	28162770	PL21	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.6743295034268211	[87]	[23]	-5	hSpCas9	negative selection	10926303
89989027	89989050	14	+	28162770	PL21	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	0.7827770622642325	[206]	[154]	6	hSpCas9	negative selection	10926304
89993400	89993423	14	-	28162770	PL21	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	-0.2569054113110991	[150]	[54]	-2	hSpCas9	negative selection	10926305
90019376	90019399	14	-	28162770	PL21	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	-1.2686298687273134	[154]	[27]	-7	hSpCas9	negative selection	10926306
89963342	89963365	14	+	28162770	PL21	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	0.6199941300659397	[298]	[199]	5	hSpCas9	negative selection	10926307
89963663	89963686	14	-	28162770	PL21	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	1.142761723411745	[435]	[418]	8	hSpCas9	negative selection	10926308
89980597	89980620	14	-	28162770	PL21	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	0.7941472548134832	[105]	[79]	6	hSpCas9	negative selection	10926309
89963227	89963250	14	+	28162770	P31FUJ	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	-1.0807991109693287	[116]	[64]	-6	hSpCas9	negative selection	11095666
89980610	89980633	14	+	28162770	P31FUJ	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	0.2784506101237685	[86]	[123]	3	hSpCas9	negative selection	11095667
89963543	89963566	14	+	28162770	P31FUJ	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	0.5146557635694698	[136]	[229]	6	hSpCas9	negative selection	11095668
89980570	89980593	14	-	28162770	P31FUJ	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	1.021439082961409	[95]	[228]	9	hSpCas9	negative selection	11095669
89989027	89989050	14	+	28162770	P31FUJ	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	0.7587855557694212	[171]	[341]	8	hSpCas9	negative selection	11095670
89993400	89993423	14	-	28162770	P31FUJ	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	-0.05047218208128576	[192]	[218]	0	hSpCas9	negative selection	11095671
90019376	90019399	14	-	28162770	P31FUJ	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	0.7306719195605071	[119]	[233]	8	hSpCas9	negative selection	11095672
89963342	89963365	14	+	28162770	P31FUJ	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	0.485784860436973	[315]	[519]	5	hSpCas9	negative selection	11095673
89963663	89963686	14	-	28162770	P31FUJ	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	-0.1393233045564417	[731]	[780]	-1	hSpCas9	negative selection	11095674
89980597	89980620	14	-	28162770	P31FUJ	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	0.9845546270247709	[122]	[285]	9	hSpCas9	negative selection	11095675
89963227	89963250	14	+	28162770	OCIAML5	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	0.29568704957969516	[50]	[112]	2	hSpCas9	negative selection	11265032
89980610	89980633	14	+	28162770	OCIAML5	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	0.230395589327976	[50]	[107]	2	hSpCas9	negative selection	11265033
89963543	89963566	14	+	28162770	OCIAML5	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	0.8169601946456337	[49]	[158]	7	hSpCas9	negative selection	11265034
89980570	89980593	14	-	28162770	OCIAML5	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.30272797987356204	[40]	[59]	-2	hSpCas9	negative selection	11265035
89989027	89989050	14	+	28162770	OCIAML5	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	-0.3495662303348137	[119]	[169]	-2	hSpCas9	negative selection	11265036
89993400	89993423	14	-	28162770	OCIAML5	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	0.9175522406209606	[82]	[282]	7	hSpCas9	negative selection	11265037
90019376	90019399	14	-	28162770	OCIAML5	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	0.8464248754875735	[56]	[184]	7	hSpCas9	negative selection	11265038
89963342	89963365	14	+	28162770	OCIAML5	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	-0.043229681505162265	[277]	[486]	0	hSpCas9	negative selection	11265039
89963663	89963686	14	-	28162770	OCIAML5	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	0.6935024915570724	[296]	[866]	6	hSpCas9	negative selection	11265040
89980597	89980620	14	-	28162770	OCIAML5	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	0.4440655231460279	[78]	[193]	4	hSpCas9	negative selection	11265041
89963227	89963250	14	+	28162770	EOL1	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	0.7352053163009814	[186]	[163]	6	hSpCas9	negative selection	11434398
89980610	89980633	14	+	28162770	EOL1	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	1.1916518417133752	[117]	[141]	8	hSpCas9	negative selection	11434399
89963543	89963566	14	+	28162770	EOL1	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	-0.08009859328583041	[310]	[154]	0	hSpCas9	negative selection	11434400
89980570	89980593	14	-	28162770	EOL1	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.3172174578209239	[194]	[127]	3	hSpCas9	negative selection	11434401
89989027	89989050	14	+	28162770	EOL1	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	-0.16127159689046938	[328]	[154]	-1	hSpCas9	negative selection	11434402
89993400	89993423	14	-	28162770	EOL1	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	-0.08971292155463502	[304]	[150]	0	hSpCas9	negative selection	11434403
90019376	90019399	14	-	28162770	EOL1	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	1.029900771716763	[131]	[141]	8	hSpCas9	negative selection	11434404
89963342	89963365	14	+	28162770	EOL1	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	0.5286190952393954	[349]	[265]	5	hSpCas9	negative selection	11434405
89963663	89963686	14	-	28162770	EOL1	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	0.1472948813023499	[580]	[338]	1	hSpCas9	negative selection	11434406
89980597	89980620	14	-	28162770	EOL1	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	-2.1372284260161556	[166]	[19]	-8	hSpCas9	negative selection	11434407
89963227	89963250	14	+	28162770	MOLM13	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	-0.15207956900449038	[145]	[94]	-1	hSpCas9	negative selection	11603764
89980610	89980633	14	+	28162770	MOLM13	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	-1.1320234606425488	[193]	[63]	-5	hSpCas9	negative selection	11603765
89963543	89963566	14	+	28162770	MOLM13	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	1.2957084061618986	[199]	[354]	8	hSpCas9	negative selection	11603766
89980570	89980593	14	-	28162770	MOLM13	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.13202209569934276	[129]	[102]	0	hSpCas9	negative selection	11603767
89989027	89989050	14	+	28162770	MOLM13	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	1.2790140863609067	[272]	[478]	8	hSpCas9	negative selection	11603768
89993400	89993423	14	-	28162770	MOLM13	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	0.9284045113412464	[241]	[332]	7	hSpCas9	negative selection	11603769
90019376	90019399	14	-	28162770	MOLM13	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	0.07911753695954094	[126]	[96]	0	hSpCas9	negative selection	11603770
89963342	89963365	14	+	28162770	MOLM13	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	-0.15258740578951563	[328]	[213]	-1	hSpCas9	negative selection	11603771
89963663	89963686	14	-	28162770	MOLM13	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	0.502088198650084	[666]	[682]	4	hSpCas9	negative selection	11603772
89980597	89980620	14	-	28162770	MOLM13	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	-0.45996083269958576	[155]	[81]	-3	hSpCas9	negative selection	11603773
89963227	89963250	14	+	28162770	HEL	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	1.154078469578333	[133]	[190]	8	hSpCas9	negative selection	11773130
89980610	89980633	14	+	28162770	HEL	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	-0.014373454476634628	[122]	[77]	0	hSpCas9	negative selection	11773131
89963543	89963566	14	+	28162770	HEL	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	0.3603391012996321	[269]	[221]	3	hSpCas9	negative selection	11773132
89980570	89980593	14	-	28162770	HEL	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.9431337653380779	[107]	[132]	7	hSpCas9	negative selection	11773133
89989027	89989050	14	+	28162770	HEL	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	0.40016852872627867	[251]	[212]	3	hSpCas9	negative selection	11773134
89993400	89993423	14	-	28162770	HEL	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	0.0667651145064555	[239]	[160]	0	hSpCas9	negative selection	11773135
90019376	90019399	14	-	28162770	HEL	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	-1.407887241069611	[144]	[34]	-7	hSpCas9	negative selection	11773136
89963342	89963365	14	+	28162770	HEL	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	-0.6982980858347101	[303]	[119]	-4	hSpCas9	negative selection	11773137
89963663	89963686	14	-	28162770	HEL	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	-0.6991231902557642	[582]	[229]	-4	hSpCas9	negative selection	11773138
89980597	89980620	14	-	28162770	HEL	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	-0.03045085173253459	[117]	[73]	0	hSpCas9	negative selection	11773139
89963227	89963250	14	+	28162770	MV411	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	0.4021601455814172	[105]	[117]	3	hSpCas9	negative selection	11942496
89980610	89980633	14	+	28162770	MV411	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	1.0749703547780096	[70]	[125]	8	hSpCas9	negative selection	11942497
89963543	89963566	14	+	28162770	MV411	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	0.2883098321983034	[173]	[178]	2	hSpCas9	negative selection	11942498
89980570	89980593	14	-	28162770	MV411	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-1.2595224379371082	[107]	[37]	-7	hSpCas9	negative selection	11942499
89989027	89989050	14	+	28162770	MV411	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	0.2850752081461404	[226]	[232]	2	hSpCas9	negative selection	11942500
89993400	89993423	14	-	28162770	MV411	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	-0.4204179582867257	[196]	[123]	-3	hSpCas9	negative selection	11942501
90019376	90019399	14	-	28162770	MV411	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	1.1109355508779133	[71]	[130]	8	hSpCas9	negative selection	11942502
89963342	89963365	14	+	28162770	MV411	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	0.29966750955533306	[216]	[224]	2	hSpCas9	negative selection	11942503
89963663	89963686	14	-	28162770	MV411	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	0.05279011992923155	[411]	[359]	0	hSpCas9	negative selection	11942504
89980597	89980620	14	-	28162770	MV411	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	1.0106346865221614	[108]	[184]	8	hSpCas9	negative selection	11942505
89963227	89963250	14	+	28162770	MONOMAC1	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	0.2180006522192902	[89]	[119]	2	hSpCas9	negative selection	12111862
89980610	89980633	14	+	28162770	MONOMAC1	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	1.581936273628228	[43]	[150]	9	hSpCas9	negative selection	12111863
89963543	89963566	14	+	28162770	MONOMAC1	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	0.3411773944701234	[114]	[166]	3	hSpCas9	negative selection	12111864
89980570	89980593	14	-	28162770	MONOMAC1	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	0.18998627604969354	[64]	[84]	2	hSpCas9	negative selection	12111865
89989027	89989050	14	+	28162770	MONOMAC1	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	0.3648420405485611	[125]	[185]	3	hSpCas9	negative selection	12111866
89993400	89993423	14	-	28162770	MONOMAC1	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	0.4653301573472091	[126]	[200]	4	hSpCas9	negative selection	12111867
90019376	90019399	14	-	28162770	MONOMAC1	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	0.7519792242216414	[71]	[138]	7	hSpCas9	negative selection	12111868
89963342	89963365	14	+	28162770	MONOMAC1	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	-0.4250648030654343	[170]	[145]	-4	hSpCas9	negative selection	12111869
89963663	89963686	14	-	28162770	MONOMAC1	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	0.2947068257014167	[292]	[411]	3	hSpCas9	negative selection	12111870
89980597	89980620	14	-	28162770	MONOMAC1	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	0.7404990659937927	[58]	[112]	7	hSpCas9	negative selection	12111871
89963227	89963250	14	+	28162770	OCIAML2	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	0.29692408875746806	[20]	[142]	3	hSpCas9	negative selection	12281228
89980610	89980633	14	+	28162770	OCIAML2	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	-0.6930222465786091	[13]	[47]	-5	hSpCas9	negative selection	12281229
89963543	89963566	14	+	28162770	OCIAML2	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	1.5697844432037469	[21]	[361]	9	hSpCas9	negative selection	12281230
89980570	89980593	14	-	28162770	OCIAML2	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.16077456265537382	[23]	[118]	-1	hSpCas9	negative selection	12281231
89989027	89989050	14	+	28162770	OCIAML2	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	0.260881338831937	[52]	[351]	2	hSpCas9	negative selection	12281232
89993400	89993423	14	-	28162770	OCIAML2	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	1.0104968644944552	[35]	[401]	8	hSpCas9	negative selection	12281233
90019376	90019399	14	-	28162770	OCIAML2	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	0.11433267547899506	[22]	[137]	1	hSpCas9	negative selection	12281234
89963342	89963365	14	+	28162770	OCIAML2	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	0.2723345095454882	[35]	[240]	2	hSpCas9	negative selection	12281235
89963663	89963686	14	-	28162770	OCIAML2	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	-0.06537334675590278	[73]	[391]	0	hSpCas9	negative selection	12281236
89980597	89980620	14	-	28162770	OCIAML2	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	0.4951544594199261	[15]	[124]	5	hSpCas9	negative selection	12281237
89963227	89963250	14	+	28162770	OCIAML3	viability	AAGGAGCAGCAAATGAGCCCAGG	TDP1	ENSG00000042088	0.5129075635923487	[25]	[111]	5	hSpCas9	negative selection	12450594
89980610	89980633	14	+	28162770	OCIAML3	viability	GACTGGCACCAGAAAACTCAAGG	TDP1	ENSG00000042088	-0.3595423866871401	[16]	[39]	-3	hSpCas9	negative selection	12450595
89963543	89963566	14	+	28162770	OCIAML3	viability	CGAGTATGAGACATCAGGGGAGG	TDP1	ENSG00000042088	-0.3716152189877153	[44]	[104]	-3	hSpCas9	negative selection	12450596
89980570	89980593	14	-	28162770	OCIAML3	viability	AGGTGTGTATGACAACCCGGAGG	TDP1	ENSG00000042088	-0.12270192139857428	[21]	[60]	-1	hSpCas9	negative selection	12450597
89989027	89989050	14	+	28162770	OCIAML3	viability	GAGCATGCTGACACTGGGGAAGG	TDP1	ENSG00000042088	-0.04075399933034521	[45]	[134]	0	hSpCas9	negative selection	12450598
89993400	89993423	14	-	28162770	OCIAML3	viability	TATGTGGCATGGCATTGCTGCGG	TDP1	ENSG00000042088	-0.04651984502166992	[51]	[151]	0	hSpCas9	negative selection	12450599
90019376	90019399	14	-	28162770	OCIAML3	viability	GGACCCCGAGCTCGTAGGAGCGG	TDP1	ENSG00000042088	0.6966695205787594	[27]	[136]	6	hSpCas9	negative selection	12450600
89963342	89963365	14	+	28162770	OCIAML3	viability	GCAGAAAAGCGGTTCCCAGGAGG	TDP1	ENSG00000042088	0.6161064512338481	[58]	[272]	5	hSpCas9	negative selection	12450601
89963663	89963686	14	-	28162770	OCIAML3	viability	GCATCCTCTTACCCTTGATGTGG	TDP1	ENSG00000042088	0.22378902845508764	[117]	[415]	2	hSpCas9	negative selection	12450602
89980597	89980620	14	-	28162770	OCIAML3	viability	GGTGCCAGTCAGCATGGATGAGG	TDP1	ENSG00000042088	-1.280849755064533	[32]	[40]	-7	hSpCas9	negative selection	12450603