Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 8940
• Symbol: TOP3B
• Description: DNA topoisomerase III beta

DataSource: http://genomecrispr.dkfz.de/#!/results/TOP3B

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
21960387	21960410	22	-	26472758	Jiyoye	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	0.3447788443680062	[188]	[180]	2	hSpCas9	negative selection	170491
21962591	21962614	22	-	26472758	Jiyoye	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	-0.8875678840552585	[183]	[74]	-6	hSpCas9	negative selection	170492
21959134	21959157	22	+	26472758	Jiyoye	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	-0.5300888631461639	[179]	[93]	-4	hSpCas9	negative selection	170493
21971916	21971939	22	-	26472758	Jiyoye	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	0.07608728733303516	[394]	[313]	0	hSpCas9	negative selection	170494
21971897	21971920	22	-	26472758	Jiyoye	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	1.3553364499862552	[84]	[163]	7	hSpCas9	negative selection	170495
21970268	21970291	22	-	26472758	Jiyoye	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	1.031207446905622	[84]	[130]	6	hSpCas9	negative selection	170496
21967602	21967625	22	-	26472758	Jiyoye	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-0.20580149538487946	[129]	[84]	-1	hSpCas9	negative selection	170497
21965337	21965360	22	-	26472758	Jiyoye	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	5.96176423318351	[0]	[46]	9	hSpCas9	negative selection	170498
21964245	21964268	22	-	26472758	Jiyoye	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	0.8256767360882887	[103]	[138]	6	hSpCas9	negative selection	170499
21963990	21964013	22	-	26472758	Jiyoye	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	-0.7187942097317049	[298]	[136]	-5	hSpCas9	negative selection	170500
21960387	21960410	22	-	26472758	KBM7	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	0.07782175853612228	[1190,828]	[532,459]	0	hSpCas9	negative selection	361609
21962591	21962614	22	-	26472758	KBM7	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	1.1378543328303117	[575,758]	[907,520]	9	hSpCas9	negative selection	361610
21959134	21959157	22	+	26472758	KBM7	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	-0.9942155668814585	[899,489]	[142,174]	-6	hSpCas9	negative selection	361611
21971916	21971939	22	-	26472758	KBM7	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	0.5735368441199282	[1487,1526]	[1573,602]	6	hSpCas9	negative selection	361612
21971897	21971920	22	-	26472758	KBM7	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	-0.2086989307747117	[1168,862]	[370,442]	-2	hSpCas9	negative selection	361613
21970268	21970291	22	-	26472758	KBM7	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	0.052170172523940905	[377,400]	[221,163]	0	hSpCas9	negative selection	361614
21967602	21967625	22	-	26472758	KBM7	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-0.5976204099082771	[355,292]	[65,130]	-5	hSpCas9	negative selection	361615
21965337	21965360	22	-	26472758	KBM7	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-0.6341143134979932	[226,236]	[55,83]	-5	hSpCas9	negative selection	361616
21964245	21964268	22	-	26472758	KBM7	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	0.8679946232095418	[642,673]	[555,580]	8	hSpCas9	negative selection	361617
21963990	21964013	22	-	26472758	KBM7	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	0.12608218596741994	[946,507]	[408,322]	1	hSpCas9	negative selection	361618
21960387	21960410	22	-	26472758	Raji	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	0.532913408470086	[410]	[137]	5	hSpCas9	negative selection	552727
21962591	21962614	22	-	26472758	Raji	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	0.2867072348181614	[271]	[76]	2	hSpCas9	negative selection	552728
21959134	21959157	22	+	26472758	Raji	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	0.019920694123260085	[305]	[71]	0	hSpCas9	negative selection	552729
21971916	21971939	22	-	26472758	Raji	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	-0.4735991144350111	[723]	[120]	-4	hSpCas9	negative selection	552730
21971897	21971920	22	-	26472758	Raji	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	0.17057736186079364	[401]	[104]	1	hSpCas9	negative selection	552731
21970268	21970291	22	-	26472758	Raji	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	-0.29254707151503595	[189]	[35]	-2	hSpCas9	negative selection	552732
21967602	21967625	22	-	26472758	Raji	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-0.9256315218543636	[220]	[26]	-6	hSpCas9	negative selection	552733
21965337	21965360	22	-	26472758	Raji	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-1.1821230818213855	[175]	[17]	-7	hSpCas9	negative selection	552734
21964245	21964268	22	-	26472758	Raji	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	-0.11968537317232164	[411]	[87]	-1	hSpCas9	negative selection	552735
21963990	21964013	22	-	26472758	Raji	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	-0.5913988649047186	[434]	[66]	-5	hSpCas9	negative selection	552736
21960387	21960410	22	-	26472758	K562	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	-2.3858246523555753	[711]	[114]	-8	hSpCas9	negative selection	743845
21962591	21962614	22	-	26472758	K562	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	-2.0469603038613085	[513]	[104]	-7	hSpCas9	negative selection	743846
21959134	21959157	22	+	26472758	K562	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	-3.083592419272759	[712]	[70]	-8	hSpCas9	negative selection	743847
21971916	21971939	22	-	26472758	K562	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	-2.5752494558300087	[1058]	[149]	-8	hSpCas9	negative selection	743848
21971897	21971920	22	-	26472758	K562	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	-2.6356206482926403	[691]	[93]	-8	hSpCas9	negative selection	743849
21970268	21970291	22	-	26472758	K562	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	-2.7779490853620077	[259]	[31]	-8	hSpCas9	negative selection	743850
21967602	21967625	22	-	26472758	K562	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-2.397687680158318	[205]	[32]	-8	hSpCas9	negative selection	743851
21965337	21965360	22	-	26472758	K562	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-4.017248842403441	[210]	[10]	-9	hSpCas9	negative selection	743852
21964245	21964268	22	-	26472758	K562	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	-2.3153731973198033	[624]	[105]	-8	hSpCas9	negative selection	743853
21963990	21964013	22	-	26472758	K562	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	-1.5255424369338506	[456]	[133]	-6	hSpCas9	negative selection	743854
21968697	21968720	22	+	26627737	DLD1	viability	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	1.0754023190538975	[206]	[172,124,113]	8	hSpCas9	negative selection	816927
21970349	21970372	22	+	26627737	DLD1	viability	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	1.2062065428054074	[512]	[474,340,302]	9	hSpCas9	negative selection	816928
21971895	21971918	22	-	26627737	DLD1	viability	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	0.2664779781215887	[654]	[253,246,238]	2	hSpCas9	negative selection	816929
21972659	21972682	22	-	26627737	DLD1	viability	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.42294254516860624	[327]	[116,59,54]	-4	hSpCas9	negative selection	816930
21974366	21974389	22	-	26627737	DLD1	viability	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.6023599191502627	[689]	[380,120,451]	6	hSpCas9	negative selection	816931
21975653	21975676	22	+	26627737	DLD1	viability	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.535060078523447	[325]	[45,129,41]	-5	hSpCas9	negative selection	816932
21968697	21968720	22	+	26627737	GBM cells	viability after 5 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.44972815319499637	[113]	[94,71]	6	hSpCas9	negative selection	899242
21970349	21970372	22	+	26627737	GBM cells	viability after 5 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.3459414884089663	[445]	[275,331]	5	hSpCas9	negative selection	899243
21971895	21971918	22	-	26627737	GBM cells	viability after 5 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	0.43803109598431944	[372]	[269,271]	6	hSpCas9	negative selection	899244
21972659	21972682	22	-	26627737	GBM cells	viability after 5 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.5937901179834819	[158]	[58,53]	-7	hSpCas9	negative selection	899245
21974366	21974389	22	-	26627737	GBM cells	viability after 5 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	-0.1905477524906514	[315]	[146,149]	-3	hSpCas9	negative selection	899246
21975653	21975676	22	+	26627737	GBM cells	viability after 5 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.914207990390805	[187]	[57,48]	-8	hSpCas9	negative selection	899247
21968697	21968720	22	+	26627737	GBM cells	viability after 13 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.3180646750914874	[113]	[91,64]	4	hSpCas9	negative selection	981557
21970349	21970372	22	+	26627737	GBM cells	viability after 13 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.1383986252396857	[445]	[283,251]	1	hSpCas9	negative selection	981558
21971895	21971918	22	-	26627737	GBM cells	viability after 13 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	0.3118821950974685	[372]	[280,226]	4	hSpCas9	negative selection	981559
21972659	21972682	22	-	26627737	GBM cells	viability after 13 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.9827242751875789	[158]	[41,44]	-8	hSpCas9	negative selection	981560
21974366	21974389	22	-	26627737	GBM cells	viability after 13 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.14627845081681096	[315]	[245,143]	2	hSpCas9	negative selection	981561
21975653	21975676	22	+	26627737	GBM cells	viability after 13 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.5850228868488505	[187]	[67,67]	-6	hSpCas9	negative selection	981562
21968697	21968720	22	+	26627737	GBM cells	viability after 21 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	1.2611225764826566	[113]	[137,157]	9	hSpCas9	negative selection	1063872
21970349	21970372	22	+	26627737	GBM cells	viability after 21 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	-0.11775537456838137	[445]	[215,229]	-1	hSpCas9	negative selection	1063873
21971895	21971918	22	-	26627737	GBM cells	viability after 21 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	0.2497582057812111	[372]	[253,228]	2	hSpCas9	negative selection	1063874
21972659	21972682	22	-	26627737	GBM cells	viability after 21 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.9202822856801767	[158]	[53,37]	-7	hSpCas9	negative selection	1063875
21974366	21974389	22	-	26627737	GBM cells	viability after 21 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.028396274707670532	[315]	[172,176]	0	hSpCas9	negative selection	1063876
21975653	21975676	22	+	26627737	GBM cells	viability after 21 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.842872359111483	[187]	[69,44]	-6	hSpCas9	negative selection	1063877
21968697	21968720	22	+	26627737	RPE1	viability after 9 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-1.9514306285290677	[1087]	[60,122]	-8	hSpCas9	negative selection	1146187
21970349	21970372	22	+	26627737	RPE1	viability after 9 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.8098432325226003	[1293]	[700,721]	5	hSpCas9	negative selection	1146188
21971895	21971918	22	-	26627737	RPE1	viability after 9 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	-0.5465350221934655	[1911]	[418,397]	-4	hSpCas9	negative selection	1146189
21972659	21972682	22	-	26627737	RPE1	viability after 9 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.22413647217011556	[440]	[60,191]	-1	hSpCas9	negative selection	1146190
21974366	21974389	22	-	26627737	RPE1	viability after 9 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	1.6564249786611032	[356]	[233,504]	8	hSpCas9	negative selection	1146191
21975653	21975676	22	+	26627737	RPE1	viability after 9 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	1.3728120421054761	[169]	[146,125]	7	hSpCas9	negative selection	1146192
21968697	21968720	22	+	26627737	RPE1	viability after 12 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-1.4893272027201174	[1087]	[107,99]	-7	hSpCas9	negative selection	1228502
21970349	21970372	22	+	26627737	RPE1	viability after 12 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.8466634777929326	[1293]	[682,563]	5	hSpCas9	negative selection	1228503
21971895	21971918	22	-	26627737	RPE1	viability after 12 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	-0.6908358359555654	[1911]	[257,381]	-5	hSpCas9	negative selection	1228504
21972659	21972682	22	-	26627737	RPE1	viability after 12 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.8150704075791819	[440]	[44,90]	-5	hSpCas9	negative selection	1228505
21974366	21974389	22	-	26627737	RPE1	viability after 12 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	1.7545263186066706	[356]	[208,444]	8	hSpCas9	negative selection	1228506
21975653	21975676	22	+	26627737	RPE1	viability after 12 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	0.4561275552640629	[169]	[84,38]	3	hSpCas9	negative selection	1228507
21968697	21968720	22	+	26627737	RPE1	viability after 15 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-2.1189581303903138	[1087]	[50,89]	-8	hSpCas9	negative selection	1310817
21970349	21970372	22	+	26627737	RPE1	viability after 15 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	1.0947301403072411	[1293]	[878,687]	6	hSpCas9	negative selection	1310818
21971895	21971918	22	-	26627737	RPE1	viability after 15 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	-0.5464138303673447	[1911]	[294,442]	-3	hSpCas9	negative selection	1310819
21972659	21972682	22	-	26627737	RPE1	viability after 15 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.2617559538097618	[440]	[44,160]	-2	hSpCas9	negative selection	1310820
21974366	21974389	22	-	26627737	RPE1	viability after 15 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	1.6361838985113524	[356]	[346,281]	8	hSpCas9	negative selection	1310821
21975653	21975676	22	+	26627737	RPE1	viability after 15 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	1.1063178634837916	[169]	[185,23]	6	hSpCas9	negative selection	1310822
21968697	21968720	22	+	26627737	RPE1	viability after 18 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-2.067437512823442	[1087]	[56,83]	-8	hSpCas9	negative selection	1393132
21970349	21970372	22	+	26627737	RPE1	viability after 18 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.9716671205779951	[1293]	[650,720]	6	hSpCas9	negative selection	1393133
21971895	21971918	22	-	26627737	RPE1	viability after 18 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	-0.5554038876002284	[1911]	[164,549]	-3	hSpCas9	negative selection	1393134
21972659	21972682	22	-	26627737	RPE1	viability after 18 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-1.7520731369931588	[440]	[44,24]	-8	hSpCas9	negative selection	1393135
21974366	21974389	22	-	26627737	RPE1	viability after 18 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	1.7939811909972319	[356]	[292,377]	8	hSpCas9	negative selection	1393136
21975653	21975676	22	+	26627737	RPE1	viability after 18 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	1.4558740442360427	[169]	[208,36]	7	hSpCas9	negative selection	1393137
21968697	21968720	22	+	26627737	HeLa	viability after 8 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-0.2784055035160389	[533]	[97,291,165]	-3	hSpCas9	negative selection	1475447
21970349	21970372	22	+	26627737	HeLa	viability after 8 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.10331081882129056	[581]	[391,288,168]	1	hSpCas9	negative selection	1475448
21971895	21971918	22	-	26627737	HeLa	viability after 8 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	0.0776225030255091	[987]	[591,323,473]	0	hSpCas9	negative selection	1475449
21972659	21972682	22	-	26627737	HeLa	viability after 8 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.6601501117162608	[256]	[156,28,46]	-6	hSpCas9	negative selection	1475450
21974366	21974389	22	-	26627737	HeLa	viability after 8 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.4171133252568117	[502]	[599,133,215]	4	hSpCas9	negative selection	1475451
21975653	21975676	22	+	26627737	HeLa	viability after 8 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	0.7890060627537838	[123]	[112,91,79]	6	hSpCas9	negative selection	1475452
21968697	21968720	22	+	26627737	HeLa	viability after 12 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-0.7601550469379146	[533]	[219,68,110]	-6	hSpCas9	negative selection	1557762
21970349	21970372	22	+	26627737	HeLa	viability after 12 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.08128119878721152	[581]	[176,283,296]	0	hSpCas9	negative selection	1557763
21971895	21971918	22	-	26627737	HeLa	viability after 12 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	0.07079629265262333	[987]	[333,303,658]	0	hSpCas9	negative selection	1557764
21972659	21972682	22	-	26627737	HeLa	viability after 12 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-1.5820344596212332	[256]	[63,18,25]	-8	hSpCas9	negative selection	1557765
21974366	21974389	22	-	26627737	HeLa	viability after 12 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.6285554450286015	[502]	[284,321,355]	5	hSpCas9	negative selection	1557766
21975653	21975676	22	+	26627737	HeLa	viability after 12 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	0.808410776553075	[123]	[14,61,192]	6	hSpCas9	negative selection	1557767
21968697	21968720	22	+	26627737	HeLa	viability after 15 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-0.9145216120348644	[533]	[173,94,72]	-7	hSpCas9	negative selection	1640077
21970349	21970372	22	+	26627737	HeLa	viability after 15 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.46379128135716896	[581]	[328,339,309]	4	hSpCas9	negative selection	1640078
21971895	21971918	22	-	26627737	HeLa	viability after 15 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	0.09185054180664753	[987]	[322,418,554]	0	hSpCas9	negative selection	1640079
21972659	21972682	22	-	26627737	HeLa	viability after 15 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-1.4247126926551115	[256]	[8,72,34]	-8	hSpCas9	negative selection	1640080
21974366	21974389	22	-	26627737	HeLa	viability after 15 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.6886198353693027	[502]	[383,352,245]	5	hSpCas9	negative selection	1640081
21975653	21975676	22	+	26627737	HeLa	viability after 15 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	0.8236634994092021	[123]	[91,134,36]	6	hSpCas9	negative selection	1640082
21968697	21968720	22	+	26627737	HeLa	viability after 18 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-0.8681885078588237	[533]	[122,79,72]	-6	hSpCas9	negative selection	1722392
21970349	21970372	22	+	26627737	HeLa	viability after 18 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.4593099309371764	[581]	[211,289,309]	4	hSpCas9	negative selection	1722393
21971895	21971918	22	-	26627737	HeLa	viability after 18 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	0.10171942767941555	[987]	[211,359,554]	0	hSpCas9	negative selection	1722394
21972659	21972682	22	-	26627737	HeLa	viability after 18 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-1.4631960708938494	[256]	[5,57,34]	-8	hSpCas9	negative selection	1722395
21974366	21974389	22	-	26627737	HeLa	viability after 18 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.6960480748288165	[502]	[257,295,245]	5	hSpCas9	negative selection	1722396
21975653	21975676	22	+	26627737	HeLa	viability after 18 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	0.7767898806226651	[123]	[59,106,36]	6	hSpCas9	negative selection	1722397
21968697	21968720	22	+	26627737	HCT116	viability after 6 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.23997489077430945	[851]	[279,90]	1	hSpCas9	negative selection	1804707
21970349	21970372	22	+	26627737	HCT116	viability after 6 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.025734872254179253	[1239]	[55,276]	0	hSpCas9	negative selection	1804708
21971895	21971918	22	-	26627737	HCT116	viability after 6 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	-0.23970620384876018	[1151]	[144,157]	-1	hSpCas9	negative selection	1804709
21972659	21972682	22	-	26627737	HCT116	viability after 6 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	3.0021981909643363	[60]	[3,116]	9	hSpCas9	negative selection	1804710
21974366	21974389	22	-	26627737	HCT116	viability after 6 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.18576686972636147	[944]	[313,88]	1	hSpCas9	negative selection	1804711
21975653	21975676	22	+	26627737	HCT116	viability after 6 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-1.3908654280628905	[247]	[10,16]	-7	hSpCas9	negative selection	1804712
21968697	21968720	22	+	26627737	HCT116	viability after 8 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-0.1358031281642268	[325]	[167,111,209]	-1	hSpCas9	negative selection	1887022
21970349	21970372	22	+	26627737	HCT116	viability after 8 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.12268094997196932	[440]	[302,193,296]	1	hSpCas9	negative selection	1887023
21971895	21971918	22	-	26627737	HCT116	viability after 8 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	0.8145405712444068	[368]	[331,353,385]	7	hSpCas9	negative selection	1887024
21972659	21972682	22	-	26627737	HCT116	viability after 8 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.25708409883398564	[164]	[49,37,138]	-3	hSpCas9	negative selection	1887025
21974366	21974389	22	-	26627737	HCT116	viability after 8 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.33486634441310076	[358]	[162,172,408]	3	hSpCas9	negative selection	1887026
21975653	21975676	22	+	26627737	HCT116	viability after 8 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.8212518184794667	[201]	[110,28,49]	-7	hSpCas9	negative selection	1887027
21968697	21968720	22	+	26627737	HCT116	viability after 9 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-1.311110952626957	[851]	[170,28]	-7	hSpCas9	negative selection	1969337
21970349	21970372	22	+	26627737	HCT116	viability after 9 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.3567858606424301	[1239]	[299,521]	2	hSpCas9	negative selection	1969338
21971895	21971918	22	-	26627737	HCT116	viability after 9 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	-0.9561452216648879	[1151]	[138,173]	-6	hSpCas9	negative selection	1969339
21972659	21972682	22	-	26627737	HCT116	viability after 9 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	3.71844994181094	[60]	[200,224]	9	hSpCas9	negative selection	1969340
21974366	21974389	22	-	26627737	HCT116	viability after 9 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	-0.1859948354244616	[944]	[194,242]	-1	hSpCas9	negative selection	1969341
21975653	21975676	22	+	26627737	HCT116	viability after 9 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-1.9055130391642738	[247]	[15,18]	-8	hSpCas9	negative selection	1969342
21968697	21968720	22	+	26627737	HCT116	viability after 12 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-1.3362554675418175	[325]	[81,54,64]	-8	hSpCas9	negative selection	2051652
21970349	21970372	22	+	26627737	HCT116	viability after 12 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.5613079949726988	[440]	[335,239,447]	5	hSpCas9	negative selection	2051653
21971895	21971918	22	-	26627737	HCT116	viability after 12 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	1.033224574621475	[368]	[366,427,398]	8	hSpCas9	negative selection	2051654
21972659	21972682	22	-	26627737	HCT116	viability after 12 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.6147589310230629	[164]	[48,33,86]	-6	hSpCas9	negative selection	2051655
21974366	21974389	22	-	26627737	HCT116	viability after 12 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.5796932042281471	[358]	[222,278,348]	5	hSpCas9	negative selection	2051656
21975653	21975676	22	+	26627737	HCT116	viability after 12 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.29529499247393665	[201]	[88,73,95]	-3	hSpCas9	negative selection	2051657
21968697	21968720	22	+	26627737	HCT116	viability after 15 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-0.5934151675622166	[325]	[216,78,87]	-6	hSpCas9	negative selection	2133967
21970349	21970372	22	+	26627737	HCT116	viability after 15 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.19211972935328014	[440]	[259,277,325]	2	hSpCas9	negative selection	2133968
21971895	21971918	22	-	26627737	HCT116	viability after 15 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	0.8398694704685415	[368]	[519,418,217]	7	hSpCas9	negative selection	2133969
21972659	21972682	22	-	26627737	HCT116	viability after 15 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.01588069415504345	[164]	[90,26,161]	0	hSpCas9	negative selection	2133970
21974366	21974389	22	-	26627737	HCT116	viability after 15 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.41020275543808776	[358]	[241,215,358]	4	hSpCas9	negative selection	2133971
21975653	21975676	22	+	26627737	HCT116	viability after 15 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.7947818499367038	[201]	[125,30,50]	-7	hSpCas9	negative selection	2133972
21968697	21968720	22	+	26627737	HCT116	viability after 18 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-0.8389600524673808	[325]	[112,54,98]	-6	hSpCas9	negative selection	2216282
21970349	21970372	22	+	26627737	HCT116	viability after 18 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.5187970739416018	[440]	[123,391,398]	4	hSpCas9	negative selection	2216283
21971895	21971918	22	-	26627737	HCT116	viability after 18 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	0.9205314851648464	[368]	[461,337,206]	7	hSpCas9	negative selection	2216284
21972659	21972682	22	-	26627737	HCT116	viability after 18 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.041415629805716225	[164]	[78,12,147]	0	hSpCas9	negative selection	2216285
21974366	21974389	22	-	26627737	HCT116	viability after 18 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.9061177812491061	[358]	[184,491,285]	7	hSpCas9	negative selection	2216286
21975653	21975676	22	+	26627737	HCT116	viability after 18 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.3577402927462803	[201]	[123,61,41]	-3	hSpCas9	negative selection	2216287
21974366	21974389	22	-	24336569	HL60	viability	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.5600819284586271	[249]	[779]	5	hSpCas9	negative selection	2302989
21974383	21974406	22	-	24336569	HL60	viability	TTCAAGATGACGTCTGTCTGTGG	TOP3B	ENSG00000100038	-0.6569971884301218	[914]	[1227]	-5	hSpCas9	negative selection	2302990
21974392	21974415	22	+	24336569	HL60	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.8335365871853108	[495]	[588]	-6	hSpCas9	negative selection	2302991
21974406	21974429	22	+	24336569	HL60	viability	GCGCACTGGCTGGCCAGCAAAGG	TOP3B	ENSG00000100038	-0.7449126712713509	[745]	[941]	-6	hSpCas9	negative selection	2302992
21974419	21974442	22	-	24336569	HL60	viability	GAGTACACTGGGACCTTTGCTGG	TOP3B	ENSG00000100038	0.5226072230399644	[499]	[1519]	4	hSpCas9	negative selection	2302993
21974430	21974453	22	-	24336569	HL60	viability	GCTCAGTCCACGAGTACACTGGG	TOP3B	ENSG00000100038	-0.3227489230722352	[710]	[1202]	-3	hSpCas9	negative selection	2302994
21974457	21974480	22	-	24336569	HL60	viability	CCTCACACAAAGGGCTGAACGGG	TOP3B	ENSG00000100038	0.6806446288286452	[619]	[2102]	6	hSpCas9	negative selection	2302995
21974462	21974485	22	+	24336569	HL60	viability	TCAGCCCTTTGTGTGAGGACAGG	TOP3B	ENSG00000100038	1.363557400734658	[621]	[3386]	8	hSpCas9	negative selection	2302996
21974467	21974490	22	-	24336569	HL60	viability	GGGAGCCTGTCCTCACACAAAGG	TOP3B	ENSG00000100038	-0.44551767118893526	[138]	[215]	-4	hSpCas9	negative selection	2302997
21975653	21975676	22	+	24336569	HL60	viability	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	0.6741877432959681	[628]	[2123]	6	hSpCas9	negative selection	2302998
21974366	21974389	22	-	24336569	KBM7	viability	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	1.9124486882733724	[70]	[728]	9	hSpCas9	negative selection	2370166
21974383	21974406	22	-	24336569	KBM7	viability	TTCAAGATGACGTCTGTCTGTGG	TOP3B	ENSG00000100038	0.34837096223647224	[634]	[2204]	3	hSpCas9	negative selection	2370167
21974392	21974415	22	+	24336569	KBM7	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	0.4876256806540498	[221]	[848]	4	hSpCas9	negative selection	2370168
21974406	21974429	22	+	24336569	KBM7	viability	GCGCACTGGCTGGCCAGCAAAGG	TOP3B	ENSG00000100038	-0.03731744220069033	[642]	[1708]	0	hSpCas9	negative selection	2370169
21974419	21974442	22	-	24336569	KBM7	viability	GAGTACACTGGGACCTTTGCTGG	TOP3B	ENSG00000100038	0.20011905952023631	[299]	[939]	1	hSpCas9	negative selection	2370170
21974430	21974453	22	-	24336569	KBM7	viability	GCTCAGTCCACGAGTACACTGGG	TOP3B	ENSG00000100038	0.40787554344861376	[610]	[2210]	4	hSpCas9	negative selection	2370171
21974457	21974480	22	-	24336569	KBM7	viability	CCTCACACAAAGGGCTGAACGGG	TOP3B	ENSG00000100038	0.3215106006729628	[452]	[1543]	3	hSpCas9	negative selection	2370172
21974462	21974485	22	+	24336569	KBM7	viability	TCAGCCCTTTGTGTGAGGACAGG	TOP3B	ENSG00000100038	1.3605697239001933	[518]	[3634]	9	hSpCas9	negative selection	2370173
21974467	21974490	22	-	24336569	KBM7	viability	GGGAGCCTGTCCTCACACAAAGG	TOP3B	ENSG00000100038	-2.1471308290719713	[202]	[124]	-8	hSpCas9	negative selection	2370174
21975653	21975676	22	+	24336569	KBM7	viability	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	0.13738330417227368	[485]	[1457]	1	hSpCas9	negative selection	2370175
21969365	21969388	22	-	25494202	A375	resistance to PLX-4720 (puromycin)	CTCAGGTGATCCGCCCACCTCAG	TOP3B	ENSG00000100038	-1.8266088487663314	[149,166]	[13,3]	-8	dCas9-VP64	positive selection	2465125
21969365	21969388	22	-	25494202	A375	resistance to PLX-4720 (zeocin)	CTCAGGTGATCCGCCCACCTCAG	TOP3B	ENSG00000100038	0.6108739619638027	[154,293]	[174,51]	4	dCas9-VP64	positive selection	2560380
21970268	21970291	22	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	0.2625545465354601	[2,3]	[2,3]	5	hSpCas9	positive selection	3028602
21972669	21972692	22	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CTTGGCTGAACAGTTCTGCGGGG	TOP3B	ENSG00000100038	0.22868096896031942	[3,4]	[4,3]	5	hSpCas9	positive selection	3028603
21972643	21972666	22	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTTAGCTTCTTTCTTCTCCGTGG	TOP3B	ENSG00000100038	0.3969968898041337	[3,3]	[3,4]	8	hSpCas9	positive selection	3028604
21968674	21968697	22	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TCTCTCCACACAGAATCCCAGGG	TOP3B	ENSG00000100038	0.23115622314589288	[2,2]	[2,2]	5	hSpCas9	positive selection	3028605
21970268	21970291	22	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	-0.1215963118337561	[2,2]	[4,0]	-2	hSpCas9	positive selection	3096460
21972669	21972692	22	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CTTGGCTGAACAGTTCTGCGGGG	TOP3B	ENSG00000100038	0.8689859973234593	[3,3]	[3,6]	9	hSpCas9	positive selection	3096461
21972643	21972666	22	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTTAGCTTCTTTCTTCTCCGTGG	TOP3B	ENSG00000100038	0.2795974255552662	[3,3]	[3,2]	5	hSpCas9	positive selection	3096462
21968674	21968697	22	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TCTCTCCACACAGAATCCCAGGG	TOP3B	ENSG00000100038	0.07582920073501864	[2,2]	[2,1]	1	hSpCas9	positive selection	3096463
21972659	21972682		-	24336571	A375	resistance to PLX after 7 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	0.31173044278474016	[6,6]	[7,8]	8	hSpCas9	positive selection	3152058
21974423	21974446		+	24336571	A375	resistance to PLX after 7 days	CAAAGGTCCCAGTGTACTCGTGG	TOP3B	ENSG00000100038	0.5314085151104379	[8,11]	[15,14]	9	hSpCas9	positive selection	3152060
21972618	21972641		+	24336571	A375	resistance to PLX after 7 days	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.2672507722341583	[9,9]	[13,10]	7	hSpCas9	positive selection	3152061
21974431	21974454		-	24336571	A375	resistance to PLX after 7 days	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.2763780247729385	[15,17]	[16,23]	7	hSpCas9	positive selection	3152062
21972659	21972682		-	24336571	A375	resistance to PLX after 14 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	0.8872765303369738	[8,5]	[5,6]	7	hSpCas9	positive selection	3209851
21974423	21974446		+	24336571	A375	resistance to PLX after 14 days	CAAAGGTCCCAGTGTACTCGTGG	TOP3B	ENSG00000100038	0.7265019446971098	[13,13]	[10,9]	6	hSpCas9	positive selection	3209853
21972618	21972641		+	24336571	A375	resistance to PLX after 14 days	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	-0.23539851864057829	[13,7]	[3,4]	-3	hSpCas9	positive selection	3209854
21974431	21974454		-	24336571	A375	resistance to PLX after 14 days	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	1.3653941418880966	[11,17]	[14,20]	8	hSpCas9	positive selection	3209855
21972659	21972682		-	24336571	A375	viability after 7 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.5319388465364253	[10]	[6,6]	-6	hSpCas9	negative selection	3267644
21974423	21974446		+	24336571	A375	viability after 7 days	CAAAGGTCCCAGTGTACTCGTGG	TOP3B	ENSG00000100038	0.05277544103067483	[10]	[8,11]	0	hSpCas9	negative selection	3267646
21972618	21972641		+	24336571	A375	viability after 7 days	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	-0.4663838442265274	[14]	[9,9]	-6	hSpCas9	negative selection	3267647
21974431	21974454		-	24336571	A375	viability after 7 days	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.07613144451233428	[18]	[15,17]	-1	hSpCas9	negative selection	3267648
21972659	21972682		-	24336571	A375	viability after 14 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.31566331766708466	[10]	[8,5]	-4	hSpCas9	negative selection	3325437
21974423	21974446		+	24336571	A375	viability after 14 days	CAAAGGTCCCAGTGTACTCGTGG	TOP3B	ENSG00000100038	0.4209992673839687	[10]	[13,13]	5	hSpCas9	negative selection	3325439
21972618	21972641		+	24336571	A375	viability after 14 days	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	-0.28907572441108387	[14]	[13,7]	-3	hSpCas9	negative selection	3325440
21974431	21974454		-	24336571	A375	viability after 14 days	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.2629220140964216	[18]	[11,17]	-3	hSpCas9	negative selection	3325441
21974392	21974415	22	+	27383988	293T	resistance to West Nile virus (flavivirus)	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	0.14880175466766601	[137,137]	[0,0]	0	hSpCas9	positive selection	3398564
21971912	21971935	22	-	27383988	293T	resistance to West Nile virus (flavivirus)	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.327636289275321	[191,191]	[0,0]	-2	hSpCas9	positive selection	3398565
21972618	21972641	22	+	27383988	293T	resistance to West Nile virus (flavivirus)	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.7978945928085379	[527,527]	[5,5]	4	hSpCas9	positive selection	3398566
21970268	21970291	22	-	26780180	HT29	viability (Avana library 4 designs)	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	1.29391900975392	[]	[]	5	hSpCas9	negative selection	3467413
21972668	21972691	22	+	26780180	HT29	viability (Avana library 4 designs)	CTTGGCTGAACAGTTCTGCGGGG	TOP3B	ENSG00000100038	0.665147577825114	[]	[]	2	hSpCas9	negative selection	3467414
21972642	21972665	22	+	26780180	HT29	viability (Avana library 4 designs)	GTTAGCTTCTTTCTTCTCCGTGG	TOP3B	ENSG00000100038	0.269939717900671	[]	[]	0	hSpCas9	negative selection	3467415
21968673	21968696	22	+	26780180	HT29	viability (Avana library 4 designs)	TCTCTCCACACAGAATCCCAGGG	TOP3B	ENSG00000100038	2.45920673264461	[]	[]	8	hSpCas9	negative selection	3467416
21968673	21968696	22	+	26780180	A375	viability (Avana lentiCRISPRv2)	TCTCTCCACACAGAATCCCAGGG	TOP3B	ENSG00000100038	-6.42601208912084	[]	[]	-6	hSpCas9	negative selection	3571558
21972642	21972665	22	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTTAGCTTCTTTCTTCTCCGTGG	TOP3B	ENSG00000100038	-1.53054178460452	[]	[]	-2	hSpCas9	negative selection	3571559
21972668	21972691	22	+	26780180	A375	viability (Avana lentiCRISPRv2)	CTTGGCTGAACAGTTCTGCGGGG	TOP3B	ENSG00000100038	5.24797653977598	[]	[]	8	hSpCas9	negative selection	3571560
21970268	21970291	22	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	2.31214650896662	[]	[]	3	hSpCas9	negative selection	3571561
21963990	21964013	22	-	26780180	A375	viability (Avana lentiCRISPRv2)	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	1.11276898796602	[]	[]	1	hSpCas9	negative selection	3571562
21967668	21967691	22	+	26780180	A375	viability (Avana lentiCRISPRv2)	TTACTCGGTCCCAGTCCAAAAGG	TOP3B	ENSG00000100038	4.17743978934043	[]	[]	7	hSpCas9	negative selection	3571563
21968673	21968696	22	+	26780180	A375	viability (Avana lentiGuide)	TCTCTCCACACAGAATCCCAGGG	TOP3B	ENSG00000100038	14.1625096519232	[]	[]	8	hSpCas9	negative selection	3680217
21972642	21972665	22	+	26780180	A375	viability (Avana lentiGuide)	GTTAGCTTCTTTCTTCTCCGTGG	TOP3B	ENSG00000100038	6.70685004972641	[]	[]	5	hSpCas9	negative selection	3680218
21972668	21972691	22	+	26780180	A375	viability (Avana lentiGuide)	CTTGGCTGAACAGTTCTGCGGGG	TOP3B	ENSG00000100038	-1.72329246986761	[]	[]	-3	hSpCas9	negative selection	3680219
21970268	21970291	22	-	26780180	A375	viability (Avana lentiGuide)	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	7.02501354940895	[]	[]	5	hSpCas9	negative selection	3680220
21963990	21964013	22	-	26780180	A375	viability (Avana lentiGuide)	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	9.95105749296266	[]	[]	7	hSpCas9	negative selection	3680221
21967668	21967691	22	+	26780180	A375	viability (Avana lentiGuide)	TTACTCGGTCCCAGTCCAAAAGG	TOP3B	ENSG00000100038	-0.0629256260985401	[]	[]	0	hSpCas9	negative selection	3680222
21968673	21968696	22	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCTCTCCACACAGAATCCCAGGG	TOP3B	ENSG00000100038	-1.3779195577027943	[1]	[0,0]	-9	hSpCas9	positive selection	3788824
21972642	21972665	22	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTAGCTTCTTTCTTCTCCGTGG	TOP3B	ENSG00000100038	-0.37518445093223196	[5]	[4,3]	-5	hSpCas9	positive selection	3788825
21972668	21972691	22	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTTGGCTGAACAGTTCTGCGGGG	TOP3B	ENSG00000100038	0.29408567165789906	[5]	[7,5]	8	hSpCas9	positive selection	3788826
21970268	21970291	22	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	0.26351078280002693	[4]	[4,5]	7	hSpCas9	positive selection	3788827
21963990	21964013	22	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	0.03008539935323229	[4]	[6,2]	0	hSpCas9	positive selection	3788828
21967668	21967691	22	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTACTCGGTCCCAGTCCAAAAGG	TOP3B	ENSG00000100038	0.19507636451101737	[5]	[6,5]	5	hSpCas9	positive selection	3788829
21968673	21968696	22	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCTCTCCACACAGAATCCCAGGG	TOP3B	ENSG00000100038	-0.5528133116781215	[4]	[1,2]	-6	hSpCas9	positive selection	3897431
21972642	21972665	22	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTAGCTTCTTTCTTCTCCGTGG	TOP3B	ENSG00000100038	-0.05492429931086154	[5]	[5,3]	-1	hSpCas9	positive selection	3897432
21972668	21972691	22	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTTGGCTGAACAGTTCTGCGGGG	TOP3B	ENSG00000100038	0.36707072100067417	[5]	[6,5]	9	hSpCas9	positive selection	3897433
21970268	21970291	22	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	0.15750165339341549	[4]	[3,4]	3	hSpCas9	positive selection	3897434
21963990	21964013	22	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	-0.16791306994715363	[5]	[3,3]	-2	hSpCas9	positive selection	3897435
21967668	21967691	22	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTACTCGGTCCCAGTCCAAAAGG	TOP3B	ENSG00000100038	0.16553859755148911	[5]	[4,5]	4	hSpCas9	positive selection	3897436
21970256	21970279	22	+	26780180	A375	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	1.05961865568588	[]	[]	5	hSpCas9	negative selection	4006803
21971912	21971935	22	-	26780180	A375	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	1.55870222469014	[]	[]	8	hSpCas9	negative selection	4006804
21972618	21972641	22	+	26780180	A375	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.602449045805512	[]	[]	2	hSpCas9	negative selection	4006805
21974392	21974415	22	+	26780180	A375	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	1.98255097009297	[]	[]	9	hSpCas9	negative selection	4006806
21970214	21970237	22	+	26780180	A375	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	1.14015028592621	[]	[]	6	hSpCas9	negative selection	4006807
21974431	21974454	22	-	26780180	A375	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	2.01748440725995	[]	[]	9	hSpCas9	negative selection	4006808
21970256	21970279	22	+	26780180	HT29	viability (GeCKOv2 library)	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	1.89664042717451	[]	[]	9	hSpCas9	negative selection	4114769
21971912	21971935	22	-	26780180	HT29	viability (GeCKOv2 library)	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	1.68347949877953	[]	[]	8	hSpCas9	negative selection	4114770
21972618	21972641	22	+	26780180	HT29	viability (GeCKOv2 library)	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.476434111217877	[]	[]	1	hSpCas9	negative selection	4114771
21974392	21974415	22	+	26780180	HT29	viability (GeCKOv2 library)	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	1.88545448306505	[]	[]	9	hSpCas9	negative selection	4114772
21970214	21970237	22	+	26780180	HT29	viability (GeCKOv2 library)	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	1.33116015687295	[]	[]	6	hSpCas9	negative selection	4114773
21974431	21974454	22	-	26780180	HT29	viability (GeCKOv2 library)	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	1.77380347625817	[]	[]	8	hSpCas9	negative selection	4114774
21972659	21972682	22	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.17011330834028265	[3]	[0,2]	-4	hSpCas9	positive selection	4178592
21974423	21974446	22	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CAAAGGTCCCAGTGTACTCGTGG	TOP3B	ENSG00000100038	0.3153078961994102	[3]	[2,3]	7	hSpCas9	positive selection	4178594
21972618	21972641	22	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.09610967959083047	[3]	[2,1]	2	hSpCas9	positive selection	4178595
21974431	21974454	22	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.30569567589954705	[3]	[1,4]	7	hSpCas9	positive selection	4178596
21972659	21972682	22	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	1.2348538571917713	[3]	[0,3,3,4]	8	hSpCas9	positive selection	4242614
21974423	21974446	22	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CAAAGGTCCCAGTGTACTCGTGG	TOP3B	ENSG00000100038	-0.5153411517318283	[3]	[0,0,0,0]	-7	hSpCas9	positive selection	4242616
21972618	21972641	22	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.7002524624101322	[4]	[5,3,5,0]	4	hSpCas9	positive selection	4242617
21974431	21974454	22	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.443392660722932	[3]	[4,2,2,0]	3	hSpCas9	positive selection	4242618
21970256	21970279	22	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.23903790125286584	[2]	[1,0]	-5	hSpCas9	positive selection	4304624
21974431	21974454	22	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.44933220046773986	[4]	[2,1]	-7	hSpCas9	positive selection	4304625
21970214	21970237	22	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.08253865898489682	[3]	[4,1]	1	hSpCas9	positive selection	4304626
21974392	21974415	22	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.6958192725634587	[2]	[1,0]	-9	hSpCas9	positive selection	4368873
21971912	21971935	22	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.15167396782440695	[3]	[3,1]	-3	hSpCas9	positive selection	4368874
21972618	21972641	22	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.423639855839271	[4]	[4,4]	8	hSpCas9	positive selection	4368875
21967653	21967675	22	-	27760321	OCIAML3	viability	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	-0.34383570143424114	[324,298]	[206,172]	-4	hSpCas9	negative selection	4449267
21968698	21968720	22	+	27760321	OCIAML3	viability	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-0.4216482445002743	[482,416]	[169,381]	-4	hSpCas9	negative selection	4449268
21970256	21970278	22	-	27760321	OCIAML3	viability	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	0.0035685879697612832	[582,430]	[366,428]	0	hSpCas9	negative selection	4449269
21974434	21974456	22	+	27760321	OCIAML3	viability	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	-0.1316378738663858	[531,460]	[356,348]	-1	hSpCas9	negative selection	4449270
21963985	21964007	22	-	27760321	OCIAML3	viability	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	0.5176354197101044	[435,383]	[455,460]	6	hSpCas9	negative selection	4449271
21967653	21967675	22	-	27760321	OCIAML2	viability	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	0.1667026920065099	[324,298]	[284,280]	2	hSpCas9	negative selection	4532730
21968698	21968720	22	+	27760321	OCIAML2	viability	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-0.04638063422003977	[482,416]	[291,429]	0	hSpCas9	negative selection	4532731
21970256	21970278	22	-	27760321	OCIAML2	viability	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	-0.04653425392815391	[582,430]	[355,442]	0	hSpCas9	negative selection	4532732
21974434	21974456	22	+	27760321	OCIAML2	viability	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	-0.004151398134860068	[531,460]	[373,432]	0	hSpCas9	negative selection	4532733
21963985	21964007	22	-	27760321	OCIAML2	viability	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	-0.1296141418185166	[435,383]	[236,388]	-2	hSpCas9	negative selection	4532734
21967653	21967675	22	-	27760321	MV411	viability	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	-0.9776986330968829	[324,298]	[24,223]	-6	hSpCas9	negative selection	4616193
21968698	21968720	22	+	27760321	MV411	viability	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	1.4547375380713472	[482,416]	[748,905]	9	hSpCas9	negative selection	4616194
21970256	21970278	22	-	27760321	MV411	viability	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	1.0103278614477198	[582,430]	[989,183]	7	hSpCas9	negative selection	4616195
21974434	21974456	22	+	27760321	MV411	viability	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	-0.0868413907471626	[531,460]	[190,482]	0	hSpCas9	negative selection	4616196
21963985	21964007	22	-	27760321	MV411	viability	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	0.2629044963557592	[435,383]	[104,652]	1	hSpCas9	negative selection	4616197
21967653	21967675	22	-	27760321	HL60	viability	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	-1.1535345672684023	[324,298]	[49,182]	-8	hSpCas9	negative selection	4699656
21968698	21968720	22	+	27760321	HL60	viability	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.04500409712608038	[482,416]	[268,493]	0	hSpCas9	negative selection	4699657
21970256	21970278	22	-	27760321	HL60	viability	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	-0.34646700556064797	[582,430]	[282,364]	-4	hSpCas9	negative selection	4699658
21974434	21974456	22	+	27760321	HL60	viability	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	0.31095552781636904	[531,460]	[429,577]	4	hSpCas9	negative selection	4699659
21963985	21964007	22	-	27760321	HL60	viability	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	-0.30638316716689584	[435,383]	[313,223]	-3	hSpCas9	negative selection	4699660
21967653	21967675	22	-	27760321	HT1080	viability	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	0.44184218316366275	[298,233]	[106,184]	2	hSpCas9	negative selection	4783119
21968698	21968720	22	+	27760321	HT1080	viability	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	1.0412341042198292	[416,325]	[232,382]	5	hSpCas9	negative selection	4783120
21970256	21970278	22	-	27760321	HT1080	viability	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	-0.7607171008917997	[430,336]	[85,94]	-3	hSpCas9	negative selection	4783121
21974434	21974456	22	+	27760321	HT1080	viability	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	0.6863635918173325	[460,359]	[350,166]	3	hSpCas9	negative selection	4783122
21963985	21964007	22	-	27760321	HT1080	viability	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	-0.3884778197171794	[383,299]	[126,78]	-2	hSpCas9	negative selection	4783123
21967653	21967675	22	-	27760321	HT29	viability after 7 days	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	-0.3371018157294829	[298,233]	[303,269,244]	-5	hSpCas9	negative selection	4866582
21968698	21968720	22	+	27760321	HT29	viability after 7 days	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.12637478112993095	[416,325]	[445,592,513]	2	hSpCas9	negative selection	4866583
21970256	21970278	22	-	27760321	HT29	viability after 7 days	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	0.3892532671769252	[430,336]	[831,849,294]	6	hSpCas9	negative selection	4866584
21974434	21974456	22	+	27760321	HT29	viability after 7 days	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	0.026649585150899602	[460,359]	[667,496,467]	0	hSpCas9	negative selection	4866585
21963985	21964007	22	-	27760321	HT29	viability after 7 days	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	0.3663689433567435	[383,299]	[429,610,636]	5	hSpCas9	negative selection	4866586
21967653	21967675	22	-	27760321	HT29	viability after 25 days	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	0.03097130998639991	[298,233]	[192,329,429]	0	hSpCas9	negative selection	4950045
21968698	21968720	22	+	27760321	HT29	viability after 25 days	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.8377550285869325	[416,325]	[634,822,832]	8	hSpCas9	negative selection	4950046
21970256	21970278	22	-	27760321	HT29	viability after 25 days	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	0.7406132936366392	[430,336]	[892,500,801]	8	hSpCas9	negative selection	4950047
21974434	21974456	22	+	27760321	HT29	viability after 25 days	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	0.2976949754581263	[460,359]	[757,569,367]	3	hSpCas9	negative selection	4950048
21963985	21964007	22	-	27760321	HT29	viability after 25 days	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	0.0956318003230405	[383,299]	[359,434,465]	0	hSpCas9	negative selection	4950049
21967653	21967675	22	-	27760321	HT29	viability after 22 days	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	-0.5369725354040105	[298,233]	[138,297,201]	-5	hSpCas9	negative selection	5033508
21968698	21968720	22	+	27760321	HT29	viability after 22 days	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.5939035351934808	[416,325]	[552,786,606]	6	hSpCas9	negative selection	5033509
21970256	21970278	22	-	27760321	HT29	viability after 22 days	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	0.6448948052622566	[430,336]	[677,609,795]	7	hSpCas9	negative selection	5033510
21974434	21974456	22	+	27760321	HT29	viability after 22 days	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	0.4077781341345493	[460,359]	[689,683,511]	4	hSpCas9	negative selection	5033511
21963985	21964007	22	-	27760321	HT29	viability after 22 days	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	0.2704558151787622	[383,299]	[242,409,786]	3	hSpCas9	negative selection	5033512
21967653	21967675	22	-	27760321	HT29	viability after 19 days	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	-0.877043378145359	[298,233]	[125,103,259]	-6	hSpCas9	negative selection	5116971
21968698	21968720	22	+	27760321	HT29	viability after 19 days	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.9798488310902566	[416,325]	[680,732,1073]	8	hSpCas9	negative selection	5116972
21970256	21970278	22	-	27760321	HT29	viability after 19 days	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	0.2084307993697774	[430,336]	[955,317,302]	2	hSpCas9	negative selection	5116973
21974434	21974456	22	+	27760321	HT29	viability after 19 days	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	0.11031705644140388	[460,359]	[519,428,569]	1	hSpCas9	negative selection	5116974
21963985	21964007	22	-	27760321	HT29	viability after 19 days	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	-0.26808384499456833	[383,299]	[235,270,452]	-3	hSpCas9	negative selection	5116975
21967653	21967675	22	-	27760321	HT29	viability after 16 days	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	-0.5020216740519239	[298,233]	[193,329,102]	-5	hSpCas9	negative selection	5200434
21968698	21968720	22	+	27760321	HT29	viability after 16 days	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	1.0021001224176243	[416,325]	[951,941,611]	9	hSpCas9	negative selection	5200435
21970256	21970278	22	-	27760321	HT29	viability after 16 days	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	0.4928845662267466	[430,336]	[713,573,536]	5	hSpCas9	negative selection	5200436
21974434	21974456	22	+	27760321	HT29	viability after 16 days	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	-0.43572868248654684	[460,359]	[393,253,377]	-4	hSpCas9	negative selection	5200437
21963985	21964007	22	-	27760321	HT29	viability after 16 days	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	-0.14587097556001927	[383,299]	[391,340,308]	-1	hSpCas9	negative selection	5200438
21967653	21967675	22	-	27760321	HT29	viability after 13 days	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	-0.5258025913842397	[298,233]	[327,151,166]	-5	hSpCas9	negative selection	5283897
21968698	21968720	22	+	27760321	HT29	viability after 13 days	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.5940729384286357	[416,325]	[617,770,567]	7	hSpCas9	negative selection	5283898
21970256	21970278	22	-	27760321	HT29	viability after 13 days	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	0.18718710346200504	[430,336]	[453,563,503]	2	hSpCas9	negative selection	5283899
21974434	21974456	22	+	27760321	HT29	viability after 13 days	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	-0.2828991342070625	[460,359]	[449,398,328]	-3	hSpCas9	negative selection	5283900
21963985	21964007	22	-	27760321	HT29	viability after 13 days	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	-0.31971475780792025	[383,299]	[110,317,512]	-4	hSpCas9	negative selection	5283901
21967653	21967675	22	-	27760321	HT29	viability after 10 days	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	-0.7109551361959219	[298,233]	[217,298,97]	-7	hSpCas9	negative selection	5367360
21968698	21968720	22	+	27760321	HT29	viability after 10 days	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.4929834471817221	[416,325]	[797,598,561]	6	hSpCas9	negative selection	5367361
21970256	21970278	22	-	27760321	HT29	viability after 10 days	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	0.19434165440944892	[430,336]	[460,590,593]	2	hSpCas9	negative selection	5367362
21974434	21974456	22	+	27760321	HT29	viability after 10 days	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	0.1809496143840839	[460,359]	[575,722,450]	2	hSpCas9	negative selection	5367363
21963985	21964007	22	-	27760321	HT29	viability after 10 days	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	-0.1556212646255225	[383,299]	[518,341,289]	-2	hSpCas9	negative selection	5367364
21967653	21967675	22	-	27760321	MOLM13	viability	CGAGTAAGAGTGTTTGACCGGG	TOP3B	ENSG00000100038	0.3519270391678467	[324,298]	[195,248]	2	hSpCas9	negative selection	5450823
21968698	21968720	22	+	27760321	MOLM13	viability	GGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.9047779561481571	[482,416]	[264,651]	6	hSpCas9	negative selection	5450824
21970256	21970278	22	-	27760321	MOLM13	viability	CACAACGAGGCGCTCTCAGTGG	TOP3B	ENSG00000100038	0.5394393415975893	[582,430]	[707,159]	4	hSpCas9	negative selection	5450825
21974434	21974456	22	+	27760321	MOLM13	viability	GTGTACTCGTGGACTGAGCAGG	TOP3B	ENSG00000100038	-0.06075033184526919	[531,460]	[477,88]	0	hSpCas9	negative selection	5450826
21963985	21964007	22	-	27760321	MOLM13	viability	GTATCAACCGCCCGCGGAAAGG	TOP3B	ENSG00000100038	0.9531999870158	[435,383]	[540,366]	6	hSpCas9	negative selection	5450827
21982556	21982579	22	+	27661255	K562	viability	GGAGAGTATCACCCCCGCCAGGG	TOP3B	ENSG00000100038	0.11797566069090115	[988,1188]	[955,927]	4	dCas9-KRAB	negative selection	5519122
21982724	21982747	22	+	27661255	K562	viability	GCTCACCCACAGCCGCACCGCGG	TOP3B	ENSG00000100038	-0.15635984630197128	[856,841]	[695,534]	-5	dCas9-KRAB	negative selection	5519123
21982345	21982368	22	-	27661255	K562	viability	GATCGGTGCGGTACACACCCAGG	TOP3B	ENSG00000100038	0.1062818701438657	[1094,1094]	[967,918]	4	dCas9-KRAB	negative selection	5519124
21982696	21982719	22	-	27661255	K562	viability	GCTGCGGGACCCTCGCCCGGCGG	TOP3B	ENSG00000100038	0.03273645353796227	[746,649]	[670,487]	1	dCas9-KRAB	negative selection	5519125
21982767	21982790	22	-	27661255	K562	viability	GGGTTGTCGGTAGCCGCCCCGGG	TOP3B	ENSG00000100038	0.4419409713867966	[739,908]	[899,883]	9	dCas9-KRAB	negative selection	5519126
21982787	21982810	22	-	27661255	K562	viability	GCGGCTGGACCCGGAAATAGGGG	TOP3B	ENSG00000100038	0.14365397460270035	[196,178]	[183,150]	5	dCas9-KRAB	negative selection	5519127
21970256	21970279	22	+	27260156	BXPC3	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.5108486101072038	[219]	[125,175,159,188]	-8	hSpCas9	negative selection	5577084
21974431	21974454	22	-	27260156	BXPC3	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.0529898164434639	[1437]	[1645,1467,1374,1755]	1	hSpCas9	negative selection	5577085
21970214	21970237	22	+	27260156	BXPC3	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.12343240664677901	[805]	[896,854,986,935]	2	hSpCas9	negative selection	5577086
21974392	21974415	22	+	27260156	BXPC3	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.2656356107297561	[443]	[373,360,336,483]	-6	hSpCas9	negative selection	5641333
21971912	21971935	22	-	27260156	BXPC3	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.2657445129464675	[556]	[424,456,486,585]	-6	hSpCas9	negative selection	5641334
21972618	21972641	22	+	27260156	BXPC3	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	-0.0006735157996620167	[1149]	[1062,1279,1112,1372]	0	hSpCas9	negative selection	5641335
21970256	21970279	22	+	27260156	A673	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.31838744524885043	[219]	[165,239,205,229]	-7	hSpCas9	negative selection	5698335
21974431	21974454	22	-	27260156	A673	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.01879326303360407	[1437]	[1700,1638,1616,2051]	0	hSpCas9	negative selection	5698336
21970214	21970237	22	+	27260156	A673	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.03268895613571998	[805]	[1151,845,967,1015]	0	hSpCas9	negative selection	5698337
21974392	21974415	22	+	27260156	A673	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.1596596654718773	[443]	[635,402,499,383]	-4	hSpCas9	negative selection	5762584
21971912	21971935	22	-	27260156	A673	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.2072150400110046	[556]	[741,460,529,606]	-5	hSpCas9	negative selection	5762585
21972618	21972641	22	+	27260156	A673	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.10532045316557337	[1149]	[1751,1449,1418,1341]	2	hSpCas9	negative selection	5762586
21970256	21970279	22	+	27260156	A375	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.6253105327958779	[219]	[220,185,161,106]	-7	hSpCas9	negative selection	5819586
21974431	21974454	22	-	27260156	A375	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.006181365006132866	[1437]	[1344,2224,1658,1594]	0	hSpCas9	negative selection	5819587
21970214	21970237	22	+	27260156	A375	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.12033082758957392	[805]	[972,1267,961,930]	1	hSpCas9	negative selection	5819588
21974392	21974415	22	+	27260156	A375	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.4046002130631427	[443]	[252,334,644,330]	-5	hSpCas9	negative selection	5883835
21971912	21971935	22	-	27260156	A375	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.07844895552693437	[556]	[610,726,573,570]	-1	hSpCas9	negative selection	5883836
21972618	21972641	22	+	27260156	A375	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.007545575815495864	[1149]	[1079,1313,1462,1511]	0	hSpCas9	negative selection	5883837
21970256	21970279	22	+	27260156	COLO741	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.07280624094406929	[219]	[271,309,222]	-1	hSpCas9	negative selection	5940837
21974431	21974454	22	-	27260156	COLO741	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.08504541685676492	[1437]	[2533,1731,1647]	1	hSpCas9	negative selection	5940838
21970214	21970237	22	+	27260156	COLO741	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.016025770282878105	[805]	[1075,957,1086]	0	hSpCas9	negative selection	5940839
21974392	21974415	22	+	27260156	COLO741	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.36566515517349	[443]	[548,424,360]	-7	hSpCas9	negative selection	6005086
21971912	21971935	22	-	27260156	COLO741	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.03481439399951758	[556]	[892,622,590]	0	hSpCas9	negative selection	6005087
21972618	21972641	22	+	27260156	COLO741	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.2010520429185192	[1149]	[1763,1690,1619]	4	hSpCas9	negative selection	6005088
21970256	21970279	22	+	27260156	CAL120	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.7311770937539663	[219]	[198,201,99]	-8	hSpCas9	negative selection	6062088
21974431	21974454	22	-	27260156	CAL120	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.00045592602689703554	[1437]	[2163,2001,1268]	0	hSpCas9	negative selection	6062089
21970214	21970237	22	+	27260156	CAL120	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.01238388943247859	[805]	[1108,922,1016]	0	hSpCas9	negative selection	6062090
21974392	21974415	22	+	27260156	CAL120	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.13125448862026523	[443]	[917,186,470]	-2	hSpCas9	negative selection	6126337
21971912	21971935	22	-	27260156	CAL120	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	0.03886286199050426	[556]	[1046,692,450]	0	hSpCas9	negative selection	6126338
21972618	21972641	22	+	27260156	CAL120	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.13452105840799078	[1149]	[2051,1472,1264]	2	hSpCas9	negative selection	6126339
21970256	21970279	22	+	27260156	CADOES1	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.19277091773769794	[219]	[165,146,224,177]	-3	hSpCas9	negative selection	6183339
21974431	21974454	22	-	27260156	CADOES1	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.14310449781129564	[1437]	[1349,1416,1579,1563]	2	hSpCas9	negative selection	6183340
21970214	21970237	22	+	27260156	CADOES1	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.09821589699813171	[805]	[808,799,663,941]	1	hSpCas9	negative selection	6183341
21974392	21974415	22	+	27260156	CADOES1	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.0426820225381868	[443]	[361,397,460,381]	0	hSpCas9	negative selection	6247588
21971912	21971935	22	-	27260156	CADOES1	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.10693985736020856	[556]	[368,343,527,690]	-2	hSpCas9	negative selection	6247589
21972618	21972641	22	+	27260156	CADOES1	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.4042559367311427	[1149]	[1561,1468,1435,1185]	6	hSpCas9	negative selection	6247590
21970256	21970279	22	+	27260156	EWS502	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.5734164547300897	[219]	[172,145,133,171]	-7	hSpCas9	negative selection	6304590
21974431	21974454	22	-	27260156	EWS502	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.02696812440264673	[1437]	[1478,1632,1251,1610]	0	hSpCas9	negative selection	6304591
21970214	21970237	22	+	27260156	EWS502	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.05164828615296302	[805]	[1013,740,1014,747]	0	hSpCas9	negative selection	6304592
21974392	21974415	22	+	27260156	EWS502	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.20321483763770687	[443]	[306,555,399,372]	-4	hSpCas9	negative selection	6368839
21971912	21971935	22	-	27260156	EWS502	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.0973111327730021	[556]	[590,443,509,665]	-2	hSpCas9	negative selection	6368840
21972618	21972641	22	+	27260156	EWS502	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.10722701815090407	[1149]	[1180,1383,1346,1346]	1	hSpCas9	negative selection	6368841
21970256	21970279	22	+	27260156	EW8	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.23955176816218682	[219]	[66,176,176,168]	-4	hSpCas9	negative selection	6425841
21974431	21974454	22	-	27260156	EW8	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.053884049007761226	[1437]	[1231,1020,953,1319]	-1	hSpCas9	negative selection	6425842
21970214	21970237	22	+	27260156	EW8	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.12093411933490195	[805]	[1130,747,445,605]	2	hSpCas9	negative selection	6425843
21974392	21974415	22	+	27260156	EW8	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.24335248796553982	[443]	[457,253,237,292]	-4	hSpCas9	negative selection	6490090
21971912	21971935	22	-	27260156	EW8	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.20593049105097777	[556]	[515,402,273,404]	-4	hSpCas9	negative selection	6490091
21972618	21972641	22	+	27260156	EW8	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.07940885715054113	[1149]	[1144,916,795,1126]	1	hSpCas9	negative selection	6490092
21970256	21970279	22	+	27260156	CORL105	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.07239002110422676	[219]	[418,143,188,226]	-1	hSpCas9	negative selection	6547092
21974431	21974454	22	-	27260156	CORL105	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.029558616026051254	[1437]	[1597,1690,1734,1846]	0	hSpCas9	negative selection	6547093
21970214	21970237	22	+	27260156	CORL105	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.03435161236739859	[805]	[945,917,1007,827]	0	hSpCas9	negative selection	6547094
21974392	21974415	22	+	27260156	CORL105	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.14818778155273626	[443]	[473,475,480,446]	-3	hSpCas9	negative selection	6611341
21971912	21971935	22	-	27260156	CORL105	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.11193692274449132	[556]	[618,548,685,573]	-2	hSpCas9	negative selection	6611342
21972618	21972641	22	+	27260156	CORL105	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.19764411298262008	[1149]	[1717,1351,1906,1265]	3	hSpCas9	negative selection	6611343
21970256	21970279	22	+	27260156	HS294T	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.20139730500334285	[219]	[34,82,52,138]	-3	hSpCas9	negative selection	6668343
21974431	21974454	22	-	27260156	HS294T	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.23285578384488237	[1437]	[635,667,597,721]	3	hSpCas9	negative selection	6668344
21970214	21970237	22	+	27260156	HS294T	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.13165973305094858	[805]	[297,346,299,439]	1	hSpCas9	negative selection	6668345
21974392	21974415	22	+	27260156	HS294T	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	0.9533541006534878	[443]	[140,264,308,694]	9	hSpCas9	negative selection	6732592
21971912	21971935	22	-	27260156	HS294T	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.13863112911551292	[556]	[188,197,206,186]	-2	hSpCas9	negative selection	6732593
21972618	21972641	22	+	27260156	HS294T	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.25558413236142097	[1149]	[503,506,452,686]	3	hSpCas9	negative selection	6732594
21970256	21970279	22	+	27260156	HCC44	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.6620737368311709	[219]	[166,138,127,190]	-7	hSpCas9	negative selection	6789594
21974431	21974454	22	-	27260156	HCC44	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.10721519518275735	[1437]	[1269,1818,2097,1809]	1	hSpCas9	negative selection	6789595
21970214	21970237	22	+	27260156	HCC44	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.04007148266122862	[805]	[943,878,989,945]	0	hSpCas9	negative selection	6789596
21974392	21974415	22	+	27260156	HCC44	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.6594239640765698	[443]	[302,224,351,403]	-7	hSpCas9	negative selection	6853843
21971912	21971935	22	-	27260156	HCC44	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.28275382817134553	[556]	[664,365,657,439]	-4	hSpCas9	negative selection	6853844
21972618	21972641	22	+	27260156	HCC44	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.016769515374342348	[1149]	[1573,1272,1327,1115]	0	hSpCas9	negative selection	6853845
21970256	21970279	22	+	27260156	G402	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.7542200038178202	[219]	[146,223,128,138]	-7	hSpCas9	negative selection	6910845
21974431	21974454	22	-	27260156	G402	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.20756514251488123	[1437]	[2409,1809,1858,2058]	2	hSpCas9	negative selection	6910846
21970214	21970237	22	+	27260156	G402	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.06269747548851012	[805]	[887,1747,622,874]	0	hSpCas9	negative selection	6910847
21974392	21974415	22	+	27260156	G402	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.7743307615546434	[443]	[242,235,487,284]	-7	hSpCas9	negative selection	6975094
21971912	21971935	22	-	27260156	G402	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	0.14942622171483566	[556]	[466,511,717,1235]	2	hSpCas9	negative selection	6975095
21972618	21972641	22	+	27260156	G402	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.5707284540986335	[1149]	[3272,2321,1234,1702]	7	hSpCas9	negative selection	6975096
21970256	21970279	22	+	27260156	L33	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	0.15995024574675898	[219]	[189,129,173,200]	3	hSpCas9	negative selection	7032096
21974431	21974454	22	-	27260156	L33	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.10338567963009249	[1437]	[1432,767,864,1497]	2	hSpCas9	negative selection	7032097
21970214	21970237	22	+	27260156	L33	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.09883653307666351	[805]	[859,282,472,704]	-2	hSpCas9	negative selection	7032098
21974392	21974415	22	+	27260156	L33	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.026980331519630155	[443]	[465,178,292,373]	0	hSpCas9	negative selection	7096345
21971912	21971935	22	-	27260156	L33	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.3338355117163846	[556]	[495,159,264,457]	-7	hSpCas9	negative selection	7096346
21972618	21972641	22	+	27260156	L33	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.18996224364972725	[1149]	[1335,602,826,1124]	4	hSpCas9	negative selection	7096347
21970256	21970279	22	+	27260156	K562	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-1.1967221372887098	[219]	[43,224,24,53]	-8	hSpCas9	negative selection	7153347
21974431	21974454	22	-	27260156	K562	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.25393129782298685	[1437]	[1097,1034,1209,947]	-3	hSpCas9	negative selection	7153348
21970214	21970237	22	+	27260156	K562	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.2903239797497953	[805]	[531,551,831,432]	-4	hSpCas9	negative selection	7153349
21974392	21974415	22	+	27260156	K562	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-1.2312687693751334	[443]	[112,324,149,94]	-8	hSpCas9	negative selection	7217596
21971912	21971935	22	-	27260156	K562	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.324880892481862	[556]	[563,368,182,464]	-4	hSpCas9	negative selection	7217597
21972618	21972641	22	+	27260156	K562	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	-1.3884499971463056	[1149]	[219,580,468,294]	-8	hSpCas9	negative selection	7217598
21970256	21970279	22	+	27260156	HT29	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.25122180652398396	[219]	[217,211,253,212]	-5	hSpCas9	negative selection	7274598
21974431	21974454	22	-	27260156	HT29	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.027056391166715654	[1437]	[1796,1749,1820,1515]	0	hSpCas9	negative selection	7274599
21970214	21970237	22	+	27260156	HT29	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.1395974885105139	[805]	[831,1229,839,697]	-3	hSpCas9	negative selection	7274600
21974392	21974415	22	+	27260156	HT29	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	0.0020638869885075822	[443]	[562,567,569,469]	0	hSpCas9	negative selection	7338847
21971912	21971935	22	-	27260156	HT29	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.11758908692522266	[556]	[567,810,647,492]	-2	hSpCas9	negative selection	7338848
21972618	21972641	22	+	27260156	HT29	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.26554121626713356	[1149]	[1989,1813,1611,1367]	5	hSpCas9	negative selection	7338849
21970256	21970279	22	+	27260156	MHHES1	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.1838627789016536	[219]	[155,283,225,203]	-3	hSpCas9	negative selection	7395849
21974431	21974454	22	-	27260156	MHHES1	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.13994019622464537	[1437]	[1943,2203,1780,1335]	2	hSpCas9	negative selection	7395850
21970214	21970237	22	+	27260156	MHHES1	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.18332183384629863	[805]	[1077,867,696,618]	-3	hSpCas9	negative selection	7395851
21974392	21974415	22	+	27260156	MHHES1	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.16008117727533444	[443]	[451,494,583,291]	-3	hSpCas9	negative selection	7460098
21971912	21971935	22	-	27260156	MHHES1	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.07724558891115305	[556]	[813,631,593,400]	-1	hSpCas9	negative selection	7460099
21972618	21972641	22	+	27260156	MHHES1	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.14791449714339655	[1149]	[1886,1351,1311,1245]	2	hSpCas9	negative selection	7460100
21970256	21970279	22	+	27260156	MEWO	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.628710748885374	[219]	[95,159,135]	-8	hSpCas9	negative selection	7517100
21974431	21974454	22	-	27260156	MEWO	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.03538739141642644	[1437]	[1594,1547,1033]	0	hSpCas9	negative selection	7517101
21970214	21970237	22	+	27260156	MEWO	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.19764377957122625	[805]	[1009,715,896]	4	hSpCas9	negative selection	7517102
21974392	21974415	22	+	27260156	MEWO	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	0.15566414100397902	[443]	[626,436,355]	3	hSpCas9	negative selection	7581349
21971912	21971935	22	-	27260156	MEWO	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.14378511065840754	[556]	[580,492,361]	-3	hSpCas9	negative selection	7581350
21972618	21972641	22	+	27260156	MEWO	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.29005858743692925	[1149]	[1345,1331,1273]	6	hSpCas9	negative selection	7581351
21970256	21970279	22	+	27260156	LNCAPCLONEFGC	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.3110079131540022	[219]	[275,67,218,91]	-5	hSpCas9	negative selection	7638351
21974431	21974454	22	-	27260156	LNCAPCLONEFGC	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.1447280302382128	[1437]	[1316,1355,1754,1385]	2	hSpCas9	negative selection	7638352
21970214	21970237	22	+	27260156	LNCAPCLONEFGC	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.168212016714963	[805]	[831,754,953,763]	2	hSpCas9	negative selection	7638353
21974392	21974415	22	+	27260156	LNCAPCLONEFGC	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.3549241473138192	[443]	[297,303,322,334]	-5	hSpCas9	negative selection	7702600
21971912	21971935	22	-	27260156	LNCAPCLONEFGC	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	0.06727190283167228	[556]	[525,595,448,526]	1	hSpCas9	negative selection	7702601
21972618	21972641	22	+	27260156	LNCAPCLONEFGC	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.4784623632582363	[1149]	[1371,1362,1976,1177]	7	hSpCas9	negative selection	7702602
21970256	21970279	22	+	27260156	PANC0327	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-1.5139917107579295	[219]	[57,90,97,22]	-9	hSpCas9	negative selection	7759602
21974431	21974454	22	-	27260156	PANC0327	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.03522988175043662	[1437]	[1284,1353,1120,1214]	0	hSpCas9	negative selection	7759603
21970214	21970237	22	+	27260156	PANC0327	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.37173115366950665	[805]	[455,385,700,683]	-5	hSpCas9	negative selection	7759604
21974392	21974415	22	+	27260156	PANC0327	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.5418620567672625	[443]	[175,346,285,256]	-6	hSpCas9	negative selection	7823851
21971912	21971935	22	-	27260156	PANC0327	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	0.2921006241169447	[556]	[935,546,623,350]	4	hSpCas9	negative selection	7823852
21972618	21972641	22	+	27260156	PANC0327	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	-0.21849495683708708	[1149]	[1350,857,741,601]	-3	hSpCas9	negative selection	7823853
21970256	21970279	22	+	27260156	NCIH2009	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.227050514502531	[219]	[445,187,190]	-3	hSpCas9	negative selection	7880853
21974431	21974454	22	-	27260156	NCIH2009	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.06404356408199807	[1437]	[2153,1824,1830]	-1	hSpCas9	negative selection	7880854
21970214	21970237	22	+	27260156	NCIH2009	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.31437224291313237	[805]	[1198,701,875]	-4	hSpCas9	negative selection	7880855
21974392	21974415	22	+	27260156	NCIH2009	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.5809705217110251	[443]	[354,337,539]	-6	hSpCas9	negative selection	7945102
21971912	21971935	22	-	27260156	NCIH2009	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	0.10097420675022789	[556]	[1069,724,755]	1	hSpCas9	negative selection	7945103
21972618	21972641	22	+	27260156	NCIH2009	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	-0.056084035776289065	[1149]	[1597,1278,1771]	0	hSpCas9	negative selection	7945104
21970256	21970279	22	+	27260156	NCIH1373	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.7137368555100256	[219]	[134,90,217,41]	-6	hSpCas9	negative selection	8002104
21974431	21974454	22	-	27260156	NCIH1373	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.2351144635678537	[1437]	[2608,1237,1389,676]	2	hSpCas9	negative selection	8002105
21970214	21970237	22	+	27260156	NCIH1373	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.08711239420258543	[805]	[866,1096,1060,200]	0	hSpCas9	negative selection	8002106
21974392	21974415	22	+	27260156	NCIH1373	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.2021843980735814	[443]	[530,419,399,102]	-2	hSpCas9	negative selection	8066353
21971912	21971935	22	-	27260156	NCIH1373	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	0.09391944076107106	[556]	[758,472,708,199]	0	hSpCas9	negative selection	8066354
21972618	21972641	22	+	27260156	NCIH1373	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.18273607249008617	[1149]	[1094,1584,1372,456]	1	hSpCas9	negative selection	8066355
21970256	21970279	22	+	27260156	PATU8902	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.12557280943819782	[219]	[167,297,323,326]	-1	hSpCas9	negative selection	8123355
21974431	21974454	22	-	27260156	PATU8902	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.43673452692254977	[1437]	[2897,3238,2466,2220]	4	hSpCas9	negative selection	8123356
21970214	21970237	22	+	27260156	PATU8902	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.18392827491148545	[805]	[895,759,1318,869]	-2	hSpCas9	negative selection	8123357
21974392	21974415	22	+	27260156	PATU8902	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.7614120709965017	[443]	[537,317,208,437]	-6	hSpCas9	negative selection	8187604
21971912	21971935	22	-	27260156	PATU8902	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.029615561923561184	[556]	[631,804,915,625]	0	hSpCas9	negative selection	8187605
21972618	21972641	22	+	27260156	PATU8902	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	-0.26546553081227664	[1149]	[1376,1742,1286,868]	-3	hSpCas9	negative selection	8187606
21970256	21970279	22	+	27260156	PANC1	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.8348484028824028	[219]	[131,149,68,82]	-8	hSpCas9	negative selection	8244606
21974431	21974454	22	-	27260156	PANC1	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.07265384470669312	[1437]	[1080,1136,1437,1040]	-1	hSpCas9	negative selection	8244607
21970214	21970237	22	+	27260156	PANC1	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.3165909396946357	[805]	[417,501,879,429]	-5	hSpCas9	negative selection	8244608
21974392	21974415	22	+	27260156	PANC1	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.4565925904364677	[443]	[204,455,241,246]	-6	hSpCas9	negative selection	8308855
21971912	21971935	22	-	27260156	PANC1	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.01706023881183502	[556]	[588,637,262,429]	0	hSpCas9	negative selection	8308856
21972618	21972641	22	+	27260156	PANC1	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.27119787964162767	[1149]	[1067,1378,1058,1268]	4	hSpCas9	negative selection	8308857
21970256	21970279	22	+	27260156	PANC0813	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.3423157333403486	[219]	[269,204,247,103]	-5	hSpCas9	negative selection	8365857
21974431	21974454	22	-	27260156	PANC0813	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.02457813030207734	[1437]	[2080,1552,1745,1533]	0	hSpCas9	negative selection	8365858
21970214	21970237	22	+	27260156	PANC0813	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.3844250590610832	[805]	[743,883,585,688]	-5	hSpCas9	negative selection	8365859
21974392	21974415	22	+	27260156	PANC0813	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.1376510851518363	[443]	[533,588,385,395]	-2	hSpCas9	negative selection	8430106
21971912	21971935	22	-	27260156	PANC0813	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.2508514566517628	[556]	[582,547,581,491]	-4	hSpCas9	negative selection	8430107
21972618	21972641	22	+	27260156	PANC0813	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.0040938644347454645	[1149]	[1320,1245,1353,1484]	0	hSpCas9	negative selection	8430108
21970256	21970279	22	+	27260156	RDES	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.4930603393750421	[219]	[157,212,110,238]	-7	hSpCas9	negative selection	8487108
21974431	21974454	22	-	27260156	RDES	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.10806245399866565	[1437]	[1284,1929,1768,2258]	1	hSpCas9	negative selection	8487109
21970214	21970237	22	+	27260156	RDES	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.2237066834010506	[805]	[884,1009,1236,1244]	3	hSpCas9	negative selection	8487110
21974392	21974415	22	+	27260156	RDES	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.3006507215014545	[443]	[374,340,448,511]	-5	hSpCas9	negative selection	8551357
21971912	21971935	22	-	27260156	RDES	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	0.10026608466967701	[556]	[537,672,680,899]	1	hSpCas9	negative selection	8551358
21972618	21972641	22	+	27260156	RDES	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.1932547036484571	[1149]	[1306,1400,1478,1931]	3	hSpCas9	negative selection	8551359
21970256	21970279	22	+	27260156	PC3	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-1.0525427895026118	[219]	[60,135,152,98]	-9	hSpCas9	negative selection	8608359
21974431	21974454	22	-	27260156	PC3	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.21985800755894136	[1437]	[798,1296,1536,1479]	-5	hSpCas9	negative selection	8608360
21970214	21970237	22	+	27260156	PC3	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.07553186833546077	[805]	[729,589,1529,755]	1	hSpCas9	negative selection	8608361
21974392	21974415	22	+	27260156	PC3	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.055539564464640145	[443]	[241,568,501,453]	-1	hSpCas9	negative selection	8672608
21971912	21971935	22	-	27260156	PC3	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.33877609638386996	[556]	[315,486,655,380]	-6	hSpCas9	negative selection	8672609
21972618	21972641	22	+	27260156	PC3	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.05837182751622949	[1149]	[760,1078,1940,1370]	1	hSpCas9	negative selection	8672610
21970256	21970279	22	+	27260156	PATU8988T	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	0.004845568864262573	[219]	[82,194,205,380]	0	hSpCas9	negative selection	8729610
21974431	21974454	22	-	27260156	PATU8988T	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.014867293552150107	[1437]	[1700,1194,1168,1425]	0	hSpCas9	negative selection	8729611
21970214	21970237	22	+	27260156	PATU8988T	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.06333997797520641	[805]	[798,785,806,578]	-1	hSpCas9	negative selection	8729612
21974392	21974415	22	+	27260156	PATU8988T	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.6010003799799972	[443]	[352,219,305,242]	-7	hSpCas9	negative selection	8793859
21971912	21971935	22	-	27260156	PATU8988T	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	0.02992404671533455	[556]	[543,659,578,413]	0	hSpCas9	negative selection	8793860
21972618	21972641	22	+	27260156	PATU8988T	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.04848279415229584	[1149]	[1117,1358,918,1229]	0	hSpCas9	negative selection	8793861
21970256	21970279	22	+	27260156	T47D	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.44497710976448945	[219]	[235,153,124,243]	-7	hSpCas9	negative selection	8850861
21974431	21974454	22	-	27260156	T47D	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.0254829057021424	[1437]	[1673,1555,1794,1560]	0	hSpCas9	negative selection	8850862
21970214	21970237	22	+	27260156	T47D	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.020513425304755972	[805]	[1043,917,890,960]	0	hSpCas9	negative selection	8850863
21974392	21974415	22	+	27260156	T47D	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	0.014958756356708416	[443]	[574,473,438,610]	0	hSpCas9	negative selection	8915110
21971912	21971935	22	-	27260156	T47D	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.11579850541617753	[556]	[648,564,596,586]	-3	hSpCas9	negative selection	8915111
21972618	21972641	22	+	27260156	T47D	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.20860917198113538	[1149]	[1398,1580,1513,1699]	4	hSpCas9	negative selection	8915112
21970256	21970279	22	+	27260156	SU8686	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	0.0036828498475638405	[219]	[221,149,228,292]	0	hSpCas9	negative selection	8972112
21974431	21974454	22	-	27260156	SU8686	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.16771496492458615	[1437]	[1469,1462,1571,1982]	3	hSpCas9	negative selection	8972113
21970214	21970237	22	+	27260156	SU8686	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.23340043748446848	[805]	[595,695,547,915]	-4	hSpCas9	negative selection	8972114
21974392	21974415	22	+	27260156	SU8686	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.08787832877089022	[443]	[330,325,596,427]	-1	hSpCas9	negative selection	9036361
21971912	21971935	22	-	27260156	SU8686	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.21516657611162726	[556]	[361,397,583,601]	-4	hSpCas9	negative selection	9036362
21972618	21972641	22	+	27260156	SU8686	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	-0.1247084550036659	[1149]	[956,948,1099,1221]	-2	hSpCas9	negative selection	9036363
21970256	21970279	22	+	27260156	SKES1	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.156535293893604	[219]	[195,80,253,234]	-3	hSpCas9	negative selection	9093363
21974431	21974454	22	-	27260156	SKES1	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.03279174869142065	[1437]	[1640,1588,1402,1282]	0	hSpCas9	negative selection	9093364
21970214	21970237	22	+	27260156	SKES1	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.020366721756303607	[805]	[878,984,957,496]	0	hSpCas9	negative selection	9093365
21974392	21974415	22	+	27260156	SKES1	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.38051777096049566	[443]	[370,352,344,298]	-7	hSpCas9	negative selection	9157612
21971912	21971935	22	-	27260156	SKES1	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.11025220861821125	[556]	[440,469,739,397]	-2	hSpCas9	negative selection	9157613
21972618	21972641	22	+	27260156	SKES1	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.14165367374115911	[1149]	[1443,1489,1246,956]	3	hSpCas9	negative selection	9157614
21970256	21970279	22	+	27260156	TOV112D	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.6321545820087651	[219]	[90,208,153,126]	-8	hSpCas9	negative selection	9214614
21974431	21974454	22	-	27260156	TOV112D	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.1299812811493839	[1437]	[1380,1484,1329,1118]	-3	hSpCas9	negative selection	9214615
21970214	21970237	22	+	27260156	TOV112D	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.10141475544332135	[805]	[743,1200,665,513]	-2	hSpCas9	negative selection	9214616
21974392	21974415	22	+	27260156	TOV112D	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	0.04088673287583264	[443]	[672,704,246,287]	0	hSpCas9	negative selection	9278863
21971912	21971935	22	-	27260156	TOV112D	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.1567386765766386	[556]	[453,505,524,512]	-3	hSpCas9	negative selection	9278864
21972618	21972641	22	+	27260156	TOV112D	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.1615461535967977	[1149]	[1186,1599,1068,1360]	3	hSpCas9	negative selection	9278865
21970256	21970279	22	+	27260156	TC71	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.27868775040383986	[219]	[228,156,173,218]	-6	hSpCas9	negative selection	9335865
21974431	21974454	22	-	27260156	TC71	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	-0.05288124165108332	[1437]	[1564,1442,1311,1636]	-1	hSpCas9	negative selection	9335866
21970214	21970237	22	+	27260156	TC71	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	-0.028213571716776187	[805]	[872,817,792,909]	0	hSpCas9	negative selection	9335867
21974392	21974415	22	+	27260156	TC71	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	0.12166210718570242	[443]	[385,513,589,585]	3	hSpCas9	negative selection	9400114
21971912	21971935	22	-	27260156	TC71	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	-0.23390747696030068	[556]	[480,499,573,471]	-6	hSpCas9	negative selection	9400115
21972618	21972641	22	+	27260156	TC71	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.10903147780508471	[1149]	[1290,1367,1267,1397]	2	hSpCas9	negative selection	9400116
21970256	21970279	22	+	27260156	TC32	viability	CCACTGAGAGCGCCTCGTTGTGG	TOP3B	ENSG00000100038	-0.3263321159616237	[219]	[196,170,171,98]	-6	hSpCas9	negative selection	9457116
21974431	21974454	22	-	27260156	TC32	viability	TGCTCAGTCCACGAGTACACTGG	TOP3B	ENSG00000100038	0.25359816705077654	[1437]	[1646,1161,2026,1756]	4	hSpCas9	negative selection	9457117
21970214	21970237	22	+	27260156	TC32	viability	TGAATGCACAGCCGATTCGCAGG	TOP3B	ENSG00000100038	0.13098957370020514	[805]	[673,650,1187,909]	2	hSpCas9	negative selection	9457118
21974392	21974415	22	+	27260156	TC32	viability	GACGTCATCTTGAAGCGCACTGG	TOP3B	ENSG00000100038	-0.13293274323731022	[443]	[360,287,410,487]	-2	hSpCas9	negative selection	9521365
21971912	21971935	22	-	27260156	TC32	viability	CGACTACATCGTGCTGTGGCTGG	TOP3B	ENSG00000100038	0.0947015408545977	[556]	[414,396,821,703]	1	hSpCas9	negative selection	9521366
21972618	21972641	22	+	27260156	TC32	viability	GAACTTCACCATGTTCAGCTTGG	TOP3B	ENSG00000100038	0.12450124426918374	[1149]	[1111,845,1438,1439]	2	hSpCas9	negative selection	9521367
21968697	21968720	22	+	27869803	HPAFII	viability after 27 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-0.5450265530093271	[219]	[69,86,NaN]	-4	hSpCas9	negative selection	9579993
21970349	21970372	22	+	27869803	HPAFII	viability after 27 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.6826665791099941	[268]	[358,116,NaN]	5	hSpCas9	negative selection	9579994
21971895	21971918	22	-	27869803	HPAFII	viability after 27 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	-0.3078601886996686	[450]	[172,206,NaN]	-2	hSpCas9	negative selection	9579995
21972659	21972682	22	-	27869803	HPAFII	viability after 27 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.48770406057721166	[176]	[103,34,NaN]	-4	hSpCas9	negative selection	9579996
21974366	21974389	22	-	27869803	HPAFII	viability after 27 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.5278816669071779	[274]	[184,227,NaN]	4	hSpCas9	negative selection	9579997
21975653	21975676	22	+	27869803	HPAFII	viability after 27 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.26401577216397887	[124]	[81,31,NaN]	-2	hSpCas9	negative selection	9579998
21968697	21968720	22	+	27869803	HPAFII	viability after 15 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-0.4619025220117663	[219]	[302,89,NaN]	-5	hSpCas9	negative selection	9662442
21970349	21970372	22	+	27869803	HPAFII	viability after 15 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.44633049284849646	[268]	[626,248,NaN]	5	hSpCas9	negative selection	9662443
21971895	21971918	22	-	27869803	HPAFII	viability after 15 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	-0.11188575465468986	[450]	[450,446,NaN]	-1	hSpCas9	negative selection	9662444
21972659	21972682	22	-	27869803	HPAFII	viability after 15 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-1.3091031144717142	[176]	[114,52,NaN]	-8	hSpCas9	negative selection	9662445
21974366	21974389	22	-	27869803	HPAFII	viability after 15 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.16586437310038138	[274]	[436,265,NaN]	2	hSpCas9	negative selection	9662446
21975653	21975676	22	+	27869803	HPAFII	viability after 15 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.3392674278320418	[124]	[165,68,NaN]	-4	hSpCas9	negative selection	9662447
21968697	21968720	22	+	27869803	ASPC1	viability after 36 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.28408765115679485	[366]	[252,173,71]	3	hSpCas9	negative selection	9744891
21970349	21970372	22	+	27869803	ASPC1	viability after 36 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.9428636211820691	[763]	[743,392,439]	8	hSpCas9	negative selection	9744892
21971895	21971918	22	-	27869803	ASPC1	viability after 36 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	1.4351046058503563	[1055]	[1293,1556,332]	9	hSpCas9	negative selection	9744893
21972659	21972682	22	-	27869803	ASPC1	viability after 36 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.26643547823075164	[298]	[157,68,49]	-3	hSpCas9	negative selection	9744894
21974366	21974389	22	-	27869803	ASPC1	viability after 36 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.3045554197574733	[719]	[75,193,563]	3	hSpCas9	negative selection	9744895
21975653	21975676	22	+	27869803	ASPC1	viability after 36 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	0.5233683895571069	[310]	[350,147,23]	5	hSpCas9	negative selection	9744896
21968697	21968720	22	+	27869803	PATU8988S	viability after 35 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.9680968257920526	[343]	[284,256,NaN]	8	hSpCas9	negative selection	9827340
21970349	21970372	22	+	27869803	PATU8988S	viability after 35 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.32070815505796757	[759]	[289,474,NaN]	3	hSpCas9	negative selection	9827341
21971895	21971918	22	-	27869803	PATU8988S	viability after 35 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	-0.9796297796716489	[1181]	[201,280,NaN]	-7	hSpCas9	negative selection	9827342
21972659	21972682	22	-	27869803	PATU8988S	viability after 35 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	0.20452415245830047	[325]	[60,241,NaN]	2	hSpCas9	negative selection	9827343
21974366	21974389	22	-	27869803	PATU8988S	viability after 35 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.02278417222995871	[660]	[250,289,NaN]	0	hSpCas9	negative selection	9827344
21975653	21975676	22	+	27869803	PATU8988S	viability after 35 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.7212787256517093	[343]	[99,67,NaN]	-6	hSpCas9	negative selection	9827345
21968697	21968720	22	+	27869803	PATU8988S	viability after 31 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.7675722408752047	[343]	[207,265,NaN]	8	hSpCas9	negative selection	9909789
21970349	21970372	22	+	27869803	PATU8988S	viability after 31 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.32182810256289296	[759]	[281,501,NaN]	4	hSpCas9	negative selection	9909790
21971895	21971918	22	-	27869803	PATU8988S	viability after 31 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	-0.5907896007737634	[1181]	[231,415,NaN]	-6	hSpCas9	negative selection	9909791
21972659	21972682	22	-	27869803	PATU8988S	viability after 31 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.47402007718592054	[325]	[31,171,NaN]	-5	hSpCas9	negative selection	9909792
21974366	21974389	22	-	27869803	PATU8988S	viability after 31 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	-0.2110157445674045	[660]	[155,318,NaN]	-2	hSpCas9	negative selection	9909793
21975653	21975676	22	+	27869803	PATU8988S	viability after 31 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.27352292102083786	[343]	[105,122,NaN]	-3	hSpCas9	negative selection	9909794
21968697	21968720	22	+	27869803	HPAFII	viability after 35 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	0.07581342090076079	[219]	[178,47,NaN]	0	hSpCas9	negative selection	9992238
21970349	21970372	22	+	27869803	HPAFII	viability after 35 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	0.5741069487229324	[268]	[269,126,NaN]	4	hSpCas9	negative selection	9992239
21971895	21971918	22	-	27869803	HPAFII	viability after 35 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	-0.1476750082144519	[450]	[175,239,NaN]	-1	hSpCas9	negative selection	9992240
21972659	21972682	22	-	27869803	HPAFII	viability after 35 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-1.0829177581792697	[176]	[54,27,NaN]	-6	hSpCas9	negative selection	9992241
21974366	21974389	22	-	27869803	HPAFII	viability after 35 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.6704655587422639	[274]	[198,246,NaN]	4	hSpCas9	negative selection	9992242
21975653	21975676	22	+	27869803	HPAFII	viability after 35 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.17664632509426115	[124]	[31,82,NaN]	-1	hSpCas9	negative selection	9992243
21968697	21968720	22	+	27869803	HPAFII	viability after 31 days	TGGAGTCTGACACGGCCCAAAGG	TOP3B	ENSG00000100038	-0.5144328776765636	[219]	[84,87,NaN]	-3	hSpCas9	negative selection	10074687
21970349	21970372	22	+	27869803	HPAFII	viability after 31 days	ACACGGTCTTCTCGCCACCATGG	TOP3B	ENSG00000100038	1.0569233525707424	[268]	[382,238,NaN]	7	hSpCas9	negative selection	10074688
21971895	21971918	22	-	27869803	HPAFII	viability after 31 days	GGCTGGACTGCGACAAGGAGGGG	TOP3B	ENSG00000100038	-0.38667728119289124	[450]	[139,251,NaN]	-3	hSpCas9	negative selection	10074689
21972659	21972682	22	-	27869803	HPAFII	viability after 31 days	ACTGTTCAGCCAAGCTCCCACGG	TOP3B	ENSG00000100038	-0.6752260100048881	[176]	[77,44,NaN]	-4	hSpCas9	negative selection	10074690
21974366	21974389	22	-	27869803	HPAFII	viability after 31 days	CTGTGGTCACGTGATGACCCTGG	TOP3B	ENSG00000100038	0.4316621509114288	[274]	[155,264,NaN]	3	hSpCas9	negative selection	10074691
21975653	21975676	22	+	27869803	HPAFII	viability after 31 days	TTTGGCAATTGACTGTGCCAAGG	TOP3B	ENSG00000100038	-0.1308038321251721	[124]	[87,37,NaN]	-1	hSpCas9	negative selection	10074692
21960387	21960410	22	-	28162770	P31FUJ	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	0.3925951607060163	[386]	[596]	4	hSpCas9	negative selection	10255296
21962591	21962614	22	-	28162770	P31FUJ	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	-0.3779573677342849	[396]	[358]	-3	hSpCas9	negative selection	10255297
21959134	21959157	22	+	28162770	P31FUJ	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	-0.3339489278712786	[191]	[178]	-3	hSpCas9	negative selection	10255298
21971916	21971939	22	-	28162770	P31FUJ	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	-0.1016902900672203	[472]	[517]	-1	hSpCas9	negative selection	10255299
21971897	21971920	22	-	28162770	P31FUJ	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	-0.6540986941649047	[307]	[229]	-5	hSpCas9	negative selection	10255300
21970268	21970291	22	-	28162770	P31FUJ	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	-0.9490092384137876	[137]	[83]	-6	hSpCas9	negative selection	10255301
21967602	21967625	22	-	28162770	P31FUJ	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-0.4851893660486638	[242]	[203]	-4	hSpCas9	negative selection	10255302
21965337	21965360	22	-	28162770	P31FUJ	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-0.8730145657009973	[172]	[110]	-6	hSpCas9	negative selection	10255303
21964245	21964268	22	-	28162770	P31FUJ	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	-0.3301638046105446	[520]	[486]	-3	hSpCas9	negative selection	10255304
21963990	21964013	22	-	28162770	P31FUJ	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	-0.05941712381438591	[508]	[573]	0	hSpCas9	negative selection	10255305
21960387	21960410	22	-	28162770	TF1	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	NaN	[NaN]	[340]	1	hSpCas9	negative selection	10424662
21962591	21962614	22	-	28162770	TF1	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	NaN	[NaN]	[247]	1	hSpCas9	negative selection	10424663
21959134	21959157	22	+	28162770	TF1	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	NaN	[NaN]	[333]	1	hSpCas9	negative selection	10424664
21971916	21971939	22	-	28162770	TF1	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	NaN	[NaN]	[262]	1	hSpCas9	negative selection	10424665
21971897	21971920	22	-	28162770	TF1	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	NaN	[NaN]	[192]	1	hSpCas9	negative selection	10424666
21970268	21970291	22	-	28162770	TF1	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	NaN	[NaN]	[35]	1	hSpCas9	negative selection	10424667
21967602	21967625	22	-	28162770	TF1	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	NaN	[NaN]	[87]	1	hSpCas9	negative selection	10424668
21965337	21965360	22	-	28162770	TF1	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	NaN	[NaN]	[46]	1	hSpCas9	negative selection	10424669
21964245	21964268	22	-	28162770	TF1	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	NaN	[NaN]	[393]	1	hSpCas9	negative selection	10424670
21963990	21964013	22	-	28162770	TF1	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	NaN	[NaN]	[371]	1	hSpCas9	negative selection	10424671
21960387	21960410	22	-	28162770	SKM1	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	0.2547240926208232	[118]	[250]	2	hSpCas9	negative selection	10594028
21962591	21962614	22	-	28162770	SKM1	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	-0.28226845129384714	[107]	[156]	-2	hSpCas9	negative selection	10594029
21959134	21959157	22	+	28162770	SKM1	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	-0.01464677596440156	[71]	[125]	0	hSpCas9	negative selection	10594030
21971916	21971939	22	-	28162770	SKM1	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	0.42166738294485717	[124]	[295]	4	hSpCas9	negative selection	10594031
21971897	21971920	22	-	28162770	SKM1	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	-0.5434661986480238	[107]	[130]	-4	hSpCas9	negative selection	10594032
21970268	21970291	22	-	28162770	SKM1	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	-0.02131050624541242	[30]	[53]	0	hSpCas9	negative selection	10594033
21967602	21967625	22	-	28162770	SKM1	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-0.10579466402259677	[55]	[91]	-1	hSpCas9	negative selection	10594034
21965337	21965360	22	-	28162770	SKM1	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-0.8594764034406684	[38]	[37]	-6	hSpCas9	negative selection	10594035
21964245	21964268	22	-	28162770	SKM1	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	-0.15775028749621012	[117]	[186]	-1	hSpCas9	negative selection	10594036
21963990	21964013	22	-	28162770	SKM1	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	-0.17205916609316518	[122]	[192]	-1	hSpCas9	negative selection	10594037
21960387	21960410	22	-	28162770	SKM1	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	0.2547240926208232	[118]	[250]	2	hSpCas9	negative selection	10763394
21962591	21962614	22	-	28162770	SKM1	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	-0.28226845129384714	[107]	[156]	-2	hSpCas9	negative selection	10763395
21959134	21959157	22	+	28162770	SKM1	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	-0.01464677596440156	[71]	[125]	0	hSpCas9	negative selection	10763396
21971916	21971939	22	-	28162770	SKM1	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	0.42166738294485717	[124]	[295]	4	hSpCas9	negative selection	10763397
21971897	21971920	22	-	28162770	SKM1	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	-0.5434661986480238	[107]	[130]	-4	hSpCas9	negative selection	10763398
21970268	21970291	22	-	28162770	SKM1	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	-0.02131050624541242	[30]	[53]	0	hSpCas9	negative selection	10763399
21967602	21967625	22	-	28162770	SKM1	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-0.10579466402259677	[55]	[91]	-1	hSpCas9	negative selection	10763400
21965337	21965360	22	-	28162770	SKM1	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-0.8594764034406684	[38]	[37]	-6	hSpCas9	negative selection	10763401
21964245	21964268	22	-	28162770	SKM1	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	-0.15775028749621012	[117]	[186]	-1	hSpCas9	negative selection	10763402
21963990	21964013	22	-	28162770	SKM1	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	-0.17205916609316518	[122]	[192]	-1	hSpCas9	negative selection	10763403
21960387	21960410	22	-	28162770	PL21	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	0.29728077289985166	[401]	[214]	2	hSpCas9	negative selection	10932760
21962591	21962614	22	-	28162770	PL21	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	0.6061319741651569	[319]	[211]	5	hSpCas9	negative selection	10932761
21959134	21959157	22	+	28162770	PL21	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	-0.9228418853427169	[256]	[58]	-6	hSpCas9	negative selection	10932762
21971916	21971939	22	-	28162770	PL21	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	-0.23469812752365526	[537]	[198]	-2	hSpCas9	negative selection	10932763
21971897	21971920	22	-	28162770	PL21	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	0.652239207989709	[268]	[183]	5	hSpCas9	negative selection	10932764
21970268	21970291	22	-	28162770	PL21	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	-0.0648325955859661	[148]	[61]	0	hSpCas9	negative selection	10932765
21967602	21967625	22	-	28162770	PL21	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	1.214639184184435	[197]	[199]	8	hSpCas9	negative selection	10932766
21965337	21965360	22	-	28162770	PL21	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-0.00149424668033038	[114]	[49]	0	hSpCas9	negative selection	10932767
21964245	21964268	22	-	28162770	PL21	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	-0.3547208544424167	[331]	[112]	-3	hSpCas9	negative selection	10932768
21963990	21964013	22	-	28162770	PL21	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	-0.1690941951763988	[402]	[155]	-1	hSpCas9	negative selection	10932769
21960387	21960410	22	-	28162770	P31FUJ	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	0.3925951607060163	[386]	[596]	4	hSpCas9	negative selection	11102126
21962591	21962614	22	-	28162770	P31FUJ	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	-0.3779573677342849	[396]	[358]	-3	hSpCas9	negative selection	11102127
21959134	21959157	22	+	28162770	P31FUJ	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	-0.3339489278712786	[191]	[178]	-3	hSpCas9	negative selection	11102128
21971916	21971939	22	-	28162770	P31FUJ	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	-0.1016902900672203	[472]	[517]	-1	hSpCas9	negative selection	11102129
21971897	21971920	22	-	28162770	P31FUJ	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	-0.6540986941649047	[307]	[229]	-5	hSpCas9	negative selection	11102130
21970268	21970291	22	-	28162770	P31FUJ	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	-0.9490092384137876	[137]	[83]	-6	hSpCas9	negative selection	11102131
21967602	21967625	22	-	28162770	P31FUJ	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-0.4851893660486638	[242]	[203]	-4	hSpCas9	negative selection	11102132
21965337	21965360	22	-	28162770	P31FUJ	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-0.8730145657009973	[172]	[110]	-6	hSpCas9	negative selection	11102133
21964245	21964268	22	-	28162770	P31FUJ	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	-0.3301638046105446	[520]	[486]	-3	hSpCas9	negative selection	11102134
21963990	21964013	22	-	28162770	P31FUJ	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	-0.05941712381438591	[508]	[573]	0	hSpCas9	negative selection	11102135
21960387	21960410	22	-	28162770	OCIAML5	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	-0.3481756807901586	[243]	[345]	-2	hSpCas9	negative selection	11271492
21962591	21962614	22	-	28162770	OCIAML5	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	-0.3314188836245544	[236]	[339]	-2	hSpCas9	negative selection	11271493
21959134	21959157	22	+	28162770	OCIAML5	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	0.5199022065229609	[84]	[219]	4	hSpCas9	negative selection	11271494
21971916	21971939	22	-	28162770	OCIAML5	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	0.2914704297612114	[281]	[622]	2	hSpCas9	negative selection	11271495
21971897	21971920	22	-	28162770	OCIAML5	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	-0.4021308636005632	[193]	[264]	-3	hSpCas9	negative selection	11271496
21970268	21970291	22	-	28162770	OCIAML5	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	-0.4788492472797802	[104]	[135]	-3	hSpCas9	negative selection	11271497
21967602	21967625	22	-	28162770	OCIAML5	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-1.3226963961061582	[96]	[69]	-6	hSpCas9	negative selection	11271498
21965337	21965360	22	-	28162770	OCIAML5	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-0.8237775264325735	[100]	[102]	-5	hSpCas9	negative selection	11271499
21964245	21964268	22	-	28162770	OCIAML5	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	0.5731154858203897	[247]	[665]	5	hSpCas9	negative selection	11271500
21963990	21964013	22	-	28162770	OCIAML5	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	0.5256197119548152	[268]	[698]	4	hSpCas9	negative selection	11271501
21960387	21960410	22	-	28162770	EOL1	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	-0.1450425006145386	[721]	[343]	-1	hSpCas9	negative selection	11440858
21962591	21962614	22	-	28162770	EOL1	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	-0.768362642517736	[429]	[132]	-5	hSpCas9	negative selection	11440859
21959134	21959157	22	+	28162770	EOL1	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	-0.4181849384561239	[453]	[178]	-3	hSpCas9	negative selection	11440860
21971916	21971939	22	-	28162770	EOL1	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	-0.4504457965989541	[982]	[378]	-3	hSpCas9	negative selection	11440861
21971897	21971920	22	-	28162770	EOL1	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	-0.42965672634058405	[564]	[220]	-3	hSpCas9	negative selection	11440862
21970268	21970291	22	-	28162770	EOL1	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	-1.245377229871778	[206]	[45]	-7	hSpCas9	negative selection	11440863
21967602	21967625	22	-	28162770	EOL1	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-0.47187404954096246	[307]	[116]	-3	hSpCas9	negative selection	11440864
21965337	21965360	22	-	28162770	EOL1	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	0.008760775473619864	[182]	[96]	0	hSpCas9	negative selection	11440865
21964245	21964268	22	-	28162770	EOL1	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	0.20962142566311737	[562]	[342]	2	hSpCas9	negative selection	11440866
21963990	21964013	22	-	28162770	EOL1	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	0.3681544230461492	[474]	[322]	3	hSpCas9	negative selection	11440867
21960387	21960410	22	-	28162770	MOLM13	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	0.761459931119463	[708]	[868]	6	hSpCas9	negative selection	11610224
21962591	21962614	22	-	28162770	MOLM13	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	-0.6073987457596581	[530]	[251]	-4	hSpCas9	negative selection	11610225
21959134	21959157	22	+	28162770	MOLM13	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	0.7781119757796623	[395]	[490]	6	hSpCas9	negative selection	11610226
21971916	21971939	22	-	28162770	MOLM13	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	0.5862587383377984	[689]	[748]	4	hSpCas9	negative selection	11610227
21971897	21971920	22	-	28162770	MOLM13	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	0.6791101887421147	[462]	[535]	5	hSpCas9	negative selection	11610228
21970268	21970291	22	-	28162770	MOLM13	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	1.0617300336121878	[215]	[325]	7	hSpCas9	negative selection	11610229
21967602	21967625	22	-	28162770	MOLM13	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-1.4402497602611988	[288]	[76]	-6	hSpCas9	negative selection	11610230
21965337	21965360	22	-	28162770	MOLM13	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-1.6576415005392802	[143]	[32]	-7	hSpCas9	negative selection	11610231
21964245	21964268	22	-	28162770	MOLM13	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	-0.5646539917197431	[537]	[262]	-3	hSpCas9	negative selection	11610232
21963990	21964013	22	-	28162770	MOLM13	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	-0.020010991093820985	[466]	[332]	0	hSpCas9	negative selection	11610233
21960387	21960410	22	-	28162770	HEL	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	0.045042841371412345	[568]	[375]	0	hSpCas9	negative selection	11779590
21962591	21962614	22	-	28162770	HEL	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	-0.39179958670412174	[464]	[226]	-3	hSpCas9	negative selection	11779591
21959134	21959157	22	+	28162770	HEL	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	0.26885865747827287	[310]	[239]	2	hSpCas9	negative selection	11779592
21971916	21971939	22	-	28162770	HEL	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	0.050651896845819167	[608]	[403]	0	hSpCas9	negative selection	11779593
21971897	21971920	22	-	28162770	HEL	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	0.7498809996616757	[453]	[488]	6	hSpCas9	negative selection	11779594
21970268	21970291	22	-	28162770	HEL	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	0.14797414025077893	[185]	[131]	1	hSpCas9	negative selection	11779595
21967602	21967625	22	-	28162770	HEL	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-0.7157151389121197	[199]	[77]	-5	hSpCas9	negative selection	11779596
21965337	21965360	22	-	28162770	HEL	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-3.647938328902566	[136]	[6]	-9	hSpCas9	negative selection	11779597
21964245	21964268	22	-	28162770	HEL	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	0.06723666052826704	[455]	[305]	0	hSpCas9	negative selection	11779598
21963990	21964013	22	-	28162770	HEL	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	0.6203710189719026	[389]	[383]	5	hSpCas9	negative selection	11779599
21960387	21960410	22	-	28162770	MV411	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	-0.19591034451944545	[445]	[327]	-1	hSpCas9	negative selection	11948956
21962591	21962614	22	-	28162770	MV411	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	0.7222772372817898	[253]	[352]	6	hSpCas9	negative selection	11948957
21959134	21959157	22	+	28162770	MV411	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	0.5483915165763962	[193]	[238]	5	hSpCas9	negative selection	11948958
21971916	21971939	22	-	28162770	MV411	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	0.566259734802316	[464]	[579]	5	hSpCas9	negative selection	11948959
21971897	21971920	22	-	28162770	MV411	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	-0.6150589254672898	[359]	[197]	-4	hSpCas9	negative selection	11948960
21970268	21970291	22	-	28162770	MV411	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	0.849595666766453	[138]	[210]	7	hSpCas9	negative selection	11948961
21967602	21967625	22	-	28162770	MV411	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-0.4997963788372582	[187]	[111]	-4	hSpCas9	negative selection	11948962
21965337	21965360	22	-	28162770	MV411	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-1.1048641931481058	[119]	[46]	-6	hSpCas9	negative selection	11948963
21964245	21964268	22	-	28162770	MV411	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	0.7047590402726631	[310]	[426]	6	hSpCas9	negative selection	11948964
21963990	21964013	22	-	28162770	MV411	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	0.7446240914154907	[383]	[541]	6	hSpCas9	negative selection	11948965
21960387	21960410	22	-	28162770	MONOMAC1	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	0.22286640739110597	[221]	[296]	2	hSpCas9	negative selection	12118322
21962591	21962614	22	-	28162770	MONOMAC1	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	-0.2901462514510351	[191]	[179]	-3	hSpCas9	negative selection	12118323
21959134	21959157	22	+	28162770	MONOMAC1	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	-0.5690056244465117	[197]	[152]	-5	hSpCas9	negative selection	12118324
21971916	21971939	22	-	28162770	MONOMAC1	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	-0.29726429479820793	[297]	[277]	-3	hSpCas9	negative selection	12118325
21971897	21971920	22	-	28162770	MONOMAC1	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	-0.7143125402691353	[228]	[159]	-5	hSpCas9	negative selection	12118326
21970268	21970291	22	-	28162770	MONOMAC1	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	-0.4276497752009701	[87]	[74]	-4	hSpCas9	negative selection	12118327
21967602	21967625	22	-	28162770	MONOMAC1	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-0.3442628002427315	[133]	[120]	-3	hSpCas9	negative selection	12118328
21965337	21965360	22	-	28162770	MONOMAC1	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-1.9214024044461264	[75]	[22]	-8	hSpCas9	negative selection	12118329
21964245	21964268	22	-	28162770	MONOMAC1	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	-0.24650552332385356	[266]	[257]	-2	hSpCas9	negative selection	12118330
21963990	21964013	22	-	28162770	MONOMAC1	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	0.628129351114511	[183]	[325]	6	hSpCas9	negative selection	12118331
21960387	21960410	22	-	28162770	OCIAML2	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	0.32394649209413995	[80]	[561]	3	hSpCas9	negative selection	12287688
21962591	21962614	22	-	28162770	OCIAML2	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	0.6689215271566322	[47]	[422]	6	hSpCas9	negative selection	12287689
21959134	21959157	22	+	28162770	OCIAML2	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	-0.44729732141153744	[45]	[186]	-4	hSpCas9	negative selection	12287690
21971916	21971939	22	-	28162770	OCIAML2	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	0.3576038264913588	[97]	[695]	3	hSpCas9	negative selection	12287691
21971897	21971920	22	-	28162770	OCIAML2	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	0.4203830258623523	[66]	[496]	4	hSpCas9	negative selection	12287692
21970268	21970291	22	-	28162770	OCIAML2	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	0.07826342077147308	[26]	[157]	0	hSpCas9	negative selection	12287693
21967602	21967625	22	-	28162770	OCIAML2	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-1.9914619885436018	[32]	[45]	-8	hSpCas9	negative selection	12287694
21965337	21965360	22	-	28162770	OCIAML2	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-0.9681294847129778	[17]	[50]	-6	hSpCas9	negative selection	12287695
21964245	21964268	22	-	28162770	OCIAML2	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	-0.12633391732634436	[63]	[324]	-1	hSpCas9	negative selection	12287696
21963990	21964013	22	-	28162770	OCIAML2	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	0.1944139991380578	[72]	[462]	1	hSpCas9	negative selection	12287697
21960387	21960410	22	-	28162770	OCIAML3	viability	CCAGCGCAACTATGTCACGGTGG	TOP3B	ENSG00000100038	-0.9102669851248335	[126]	[203]	-6	hSpCas9	negative selection	12457054
21962591	21962614	22	-	28162770	OCIAML3	viability	TATCTCTCCAGGCTTCACGGAGG	TOP3B	ENSG00000100038	-0.23245247131608976	[78]	[202]	-2	hSpCas9	negative selection	12457055
21959134	21959157	22	+	28162770	OCIAML3	viability	GGATGTACTTCATGAAGCGGTGG	TOP3B	ENSG00000100038	-1.387556762856737	[64]	[74]	-7	hSpCas9	negative selection	12457056
21971916	21971939	22	-	28162770	OCIAML3	viability	GCTGCGACTACATCGTGCTGTGG	TOP3B	ENSG00000100038	-0.12572811976833997	[132]	[367]	-1	hSpCas9	negative selection	12457057
21971897	21971920	22	-	28162770	OCIAML3	viability	GTGGCTGGACTGCGACAAGGAGG	TOP3B	ENSG00000100038	-0.7798741856354972	[90]	[159]	-5	hSpCas9	negative selection	12457058
21970268	21970291	22	-	28162770	OCIAML3	viability	AGGCGAGCCTGACCACAACGAGG	TOP3B	ENSG00000100038	1.1932630356901086	[30]	[213]	8	hSpCas9	negative selection	12457059
21967602	21967625	22	-	28162770	OCIAML3	viability	AAAGCTGGAGAAGGAAGCCCAGG	TOP3B	ENSG00000100038	-0.51600512832289	[53]	[113]	-4	hSpCas9	negative selection	12457060
21965337	21965360	22	-	28162770	OCIAML3	viability	GGAAAGAAAAGGCCAAGCAGAGG	TOP3B	ENSG00000100038	-1.2963270916834781	[47]	[58]	-7	hSpCas9	negative selection	12457061
21964245	21964268	22	-	28162770	OCIAML3	viability	AAGGCTACATCAGCTACCCACGG	TOP3B	ENSG00000100038	-0.49909599329869647	[124]	[266]	-4	hSpCas9	negative selection	12457062
21963990	21964013	22	-	28162770	OCIAML3	viability	CAGAAGGTATCAACCGCCCGCGG	TOP3B	ENSG00000100038	-0.22954550159824638	[126]	[326]	-2	hSpCas9	negative selection	12457063