Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 55737
• Symbol: Vps35
• Description: VPS35 retromer complex component

DataSource: http://genomecrispr.dkfz.de/#!/results/Vps35

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
46668967	46668990	16	+	26472758	Jiyoye	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-1.8905051671348116	[235]	[47]	-8	hSpCas9	negative selection	180072
46674614	46674637	16	-	26472758	Jiyoye	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-2.708301835914063	[25]	[2]	-9	hSpCas9	negative selection	180073
46662346	46662369	16	+	26472758	Jiyoye	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	0.8926022086761154	[19]	[27]	6	hSpCas9	negative selection	180074
46663096	46663119	16	+	26472758	Jiyoye	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	0.7291034763932358	[35]	[44]	5	hSpCas9	negative selection	180075
46663033	46663056	16	-	26472758	Jiyoye	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-1.8183843189092577	[303]	[64]	-8	hSpCas9	negative selection	180076
46662408	46662431	16	+	26472758	Jiyoye	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-0.7701291503020362	[293]	[129]	-5	hSpCas9	negative selection	180077
46662360	46662383	16	-	26472758	Jiyoye	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	-0.42592730974938225	[211]	[118]	-3	hSpCas9	negative selection	180078
46681472	46681495	16	+	26472758	Jiyoye	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-1.2766405061415678	[150]	[46]	-7	hSpCas9	negative selection	180079
46680788	46680811	16	+	26472758	Jiyoye	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.26411233241403775	[285]	[258]	2	hSpCas9	negative selection	180080
46676634	46676657	16	+	26472758	Jiyoye	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	-2.5928246184941264	[39]	[4]	-9	hSpCas9	negative selection	180081
46668967	46668990	16	+	26472758	KBM7	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-2.9869045081824863	[754,721]	[54,33]	-9	hSpCas9	negative selection	371190
46674614	46674637	16	-	26472758	KBM7	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.9418355887550518	[183,163]	[34,8]	-8	hSpCas9	negative selection	371191
46662346	46662369	16	+	26472758	KBM7	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	-0.5074498229628156	[299,225]	[101,71]	-4	hSpCas9	negative selection	371192
46663096	46663119	16	+	26472758	KBM7	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-1.6004867589368277	[757,820]	[179,72]	-8	hSpCas9	negative selection	371193
46663033	46663056	16	-	26472758	KBM7	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-1.7747592632627096	[782,743]	[158,56]	-8	hSpCas9	negative selection	371194
46662408	46662431	16	+	26472758	KBM7	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-1.4469518791228402	[1725,1394]	[219,309]	-7	hSpCas9	negative selection	371195
46662360	46662383	16	-	26472758	KBM7	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	0.2035640460725713	[584,406]	[303,229]	2	hSpCas9	negative selection	371196
46681472	46681495	16	+	26472758	KBM7	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.7890060168163929	[518,658]	[228,103]	-6	hSpCas9	negative selection	371197
46680788	46680811	16	+	26472758	KBM7	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.3273978708540801	[1145,1047]	[507,771]	3	hSpCas9	negative selection	371198
46676634	46676657	16	+	26472758	KBM7	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	0.4096554997995203	[103,69]	[5,95]	4	hSpCas9	negative selection	371199
46668967	46668990	16	+	26472758	Raji	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-2.4286693648666104	[463]	[19]	-9	hSpCas9	negative selection	562308
46674614	46674637	16	-	26472758	Raji	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.4624720729573482	[94]	[7]	-7	hSpCas9	negative selection	562309
46662346	46662369	16	+	26472758	Raji	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	-1.9223638080204526	[97]	[5]	-8	hSpCas9	negative selection	562310
46663096	46663119	16	+	26472758	Raji	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-2.6130939360040375	[289]	[10]	-9	hSpCas9	negative selection	562311
46663033	46663056	16	-	26472758	Raji	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-1.4295574504846134	[324]	[27]	-7	hSpCas9	negative selection	562312
46662408	46662431	16	+	26472758	Raji	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-1.5695972099435038	[792]	[61]	-8	hSpCas9	negative selection	562313
46662360	46662383	16	-	26472758	Raji	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	1.1318365790981384	[233]	[118]	8	hSpCas9	negative selection	562314
46681472	46681495	16	+	26472758	Raji	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-1.200044989818648	[296]	[29]	-7	hSpCas9	negative selection	562315
46680788	46680811	16	+	26472758	Raji	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	-0.14806717454214402	[720]	[150]	-1	hSpCas9	negative selection	562316
46676634	46676657	16	+	26472758	Raji	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	0.10738353537359968	[51]	[12]	1	hSpCas9	negative selection	562317
46668967	46668990	16	+	26472758	K562	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-3.3672117235167898	[818]	[66]	-8	hSpCas9	negative selection	753426
46674614	46674637	16	-	26472758	K562	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.6749628121252687	[86]	[22]	-7	hSpCas9	negative selection	753427
46662346	46662369	16	+	26472758	K562	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	-0.9356163014207066	[178]	[78]	-5	hSpCas9	negative selection	753428
46663096	46663119	16	+	26472758	K562	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-1.0850825869257164	[572]	[227]	-5	hSpCas9	negative selection	753429
46663033	46663056	16	-	26472758	K562	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-1.7393710451522941	[707]	[178]	-7	hSpCas9	negative selection	753430
46662408	46662431	16	+	26472758	K562	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-0.28378899475747565	[1457]	[1010]	-2	hSpCas9	negative selection	753431
46662360	46662383	16	-	26472758	K562	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	0.7789198935468621	[416]	[603]	6	hSpCas9	negative selection	753432
46681472	46681495	16	+	26472758	K562	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-1.6244585420053403	[514]	[140]	-7	hSpCas9	negative selection	753433
46680788	46680811	16	+	26472758	K562	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.839976343626802	[813]	[1229]	7	hSpCas9	negative selection	753434
46676634	46676657	16	+	26472758	K562	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	-2.4254326706412224	[69]	[10]	-8	hSpCas9	negative selection	753435
46661844	46661867	16	-	26627737	DLD1	viability	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	-0.6745507453848791	[536]	[83,106,121]	-6	hSpCas9	negative selection	794170
46662260	46662283	16	-	26627737	DLD1	viability	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	0.40856437587539374	[740]	[364,219,329]	4	hSpCas9	negative selection	794171
46663081	46663104	16	-	26627737	DLD1	viability	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-0.8319434039959763	[119]	[15,46,3]	-7	hSpCas9	negative selection	794172
46668959	46668982	16	-	26627737	DLD1	viability	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-1.6777119981207682	[50]	[2,0,9]	-8	hSpCas9	negative selection	794173
46671740	46671763	16	+	26627737	DLD1	viability	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	-1.7319029197423408	[174]	[4,22,20]	-8	hSpCas9	negative selection	794174
46689039	46689062	16	-	26627737	DLD1	viability	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	-0.5753252365931072	[625]	[189,114,93]	-5	hSpCas9	negative selection	794175
46661844	46661867	16	-	26627737	GBM cells	viability after 5 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.5975909843275181	[251]	[210,197]	8	hSpCas9	negative selection	876485
46662260	46662283	16	-	26627737	GBM cells	viability after 5 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	0.09724259133166424	[474]	[281,262]	1	hSpCas9	negative selection	876486
46663081	46663104	16	-	26627737	GBM cells	viability after 5 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-0.10108612511431447	[119]	[44,74]	-1	hSpCas9	negative selection	876487
46668959	46668982	16	-	26627737	GBM cells	viability after 5 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	0.17454831749911315	[56]	[36,31]	2	hSpCas9	negative selection	876488
46671740	46671763	16	+	26627737	GBM cells	viability after 5 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	1.4323460749667596	[37]	[47,61]	9	hSpCas9	negative selection	876489
46689039	46689062	16	-	26627737	GBM cells	viability after 5 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.24230333305596818	[386]	[247,242]	4	hSpCas9	negative selection	876490
46661844	46661867	16	-	26627737	GBM cells	viability after 13 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.548732429137131	[251]	[215,186]	6	hSpCas9	negative selection	958800
46662260	46662283	16	-	26627737	GBM cells	viability after 13 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	0.277386686149249	[474]	[345,284]	3	hSpCas9	negative selection	958801
46663081	46663104	16	-	26627737	GBM cells	viability after 13 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-1.2773842749183921	[119]	[22,29]	-8	hSpCas9	negative selection	958802
46668959	46668982	16	-	26627737	GBM cells	viability after 13 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	0.047886493190675505	[56]	[42,22]	0	hSpCas9	negative selection	958803
46671740	46671763	16	+	26627737	GBM cells	viability after 13 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	0.559337307749582	[37]	[36,24]	7	hSpCas9	negative selection	958804
46689039	46689062	16	-	26627737	GBM cells	viability after 13 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.37407804137128053	[386]	[334,220]	5	hSpCas9	negative selection	958805
46661844	46661867	16	-	26627737	GBM cells	viability after 21 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	1.160760241477877	[251]	[303,307]	9	hSpCas9	negative selection	1041115
46662260	46662283	16	-	26627737	GBM cells	viability after 21 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.03363451137262674	[474]	[272,232]	0	hSpCas9	negative selection	1041116
46663081	46663104	16	-	26627737	GBM cells	viability after 21 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-1.380238592150314	[119]	[23,25]	-8	hSpCas9	negative selection	1041117
46668959	46668982	16	-	26627737	GBM cells	viability after 21 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-1.1953963581650298	[56]	[12,13]	-7	hSpCas9	negative selection	1041118
46671740	46671763	16	+	26627737	GBM cells	viability after 21 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	-1.2764645426546686	[37]	[7,8]	-8	hSpCas9	negative selection	1041119
46689039	46689062	16	-	26627737	GBM cells	viability after 21 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.0811285965973384	[386]	[247,198]	0	hSpCas9	negative selection	1041120
46661844	46661867	16	-	26627737	RPE1	viability after 9 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.7196752453872806	[617]	[284,361]	5	hSpCas9	negative selection	1123430
46662260	46662283	16	-	26627737	RPE1	viability after 9 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.10959901411798179	[1192]	[336,357]	-1	hSpCas9	negative selection	1123431
46663081	46663104	16	-	26627737	RPE1	viability after 9 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	0.9226512578789725	[110]	[33,106]	6	hSpCas9	negative selection	1123432
46668959	46668982	16	-	26627737	RPE1	viability after 9 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-1.4689362965530888	[301]	[17,54]	-8	hSpCas9	negative selection	1123433
46671740	46671763	16	+	26627737	RPE1	viability after 9 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	-0.17827878754523185	[176]	[65,26]	-1	hSpCas9	negative selection	1123434
46689039	46689062	16	-	26627737	RPE1	viability after 9 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.2511472630643252	[1200]	[319,611]	1	hSpCas9	negative selection	1123435
46661844	46661867	16	-	26627737	RPE1	viability after 12 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.12676981555226516	[617]	[139,224]	0	hSpCas9	negative selection	1205745
46662260	46662283	16	-	26627737	RPE1	viability after 12 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.05520704532117304	[1192]	[256,362]	0	hSpCas9	negative selection	1205746
46663081	46663104	16	-	26627737	RPE1	viability after 12 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-0.09685013405904819	[110]	[40,13]	0	hSpCas9	negative selection	1205747
46668959	46668982	16	-	26627737	RPE1	viability after 12 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-3.677160478246802	[301]	[0,11]	-9	hSpCas9	negative selection	1205748
46671740	46671763	16	+	26627737	RPE1	viability after 12 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	-1.0372190511375532	[176]	[28,16]	-6	hSpCas9	negative selection	1205749
46689039	46689062	16	-	26627737	RPE1	viability after 12 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.17093833211586318	[1200]	[388,335]	1	hSpCas9	negative selection	1205750
46661844	46661867	16	-	26627737	RPE1	viability after 15 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.3839773255936281	[617]	[220,234]	2	hSpCas9	negative selection	1288060
46662260	46662283	16	-	26627737	RPE1	viability after 15 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.29282757766235373	[1192]	[360,192]	-2	hSpCas9	negative selection	1288061
46663081	46663104	16	-	26627737	RPE1	viability after 15 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	0.3340854922575689	[110]	[34,43]	2	hSpCas9	negative selection	1288062
46668959	46668982	16	-	26627737	RPE1	viability after 15 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-3.1536894615538795	[301]	[3,14]	-9	hSpCas9	negative selection	1288063
46671740	46671763	16	+	26627737	RPE1	viability after 15 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	-1.876534886148086	[176]	[5,20]	-8	hSpCas9	negative selection	1288064
46689039	46689062	16	-	26627737	RPE1	viability after 15 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	-0.024743185134541434	[1200]	[279,385]	0	hSpCas9	negative selection	1288065
46661844	46661867	16	-	26627737	RPE1	viability after 18 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.08387801439893916	[617]	[96,261]	0	hSpCas9	negative selection	1370375
46662260	46662283	16	-	26627737	RPE1	viability after 18 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.9598367611174828	[1192]	[136,195]	-5	hSpCas9	negative selection	1370376
46663081	46663104	16	-	26627737	RPE1	viability after 18 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	0.12569726413254978	[110]	[37,26]	0	hSpCas9	negative selection	1370377
46668959	46668982	16	-	26627737	RPE1	viability after 18 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-3.689374602842549	[301]	[0,11]	-9	hSpCas9	negative selection	1370378
46671740	46671763	16	+	26627737	RPE1	viability after 18 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	-5.577937289982255	[176]	[0,0]	-9	hSpCas9	negative selection	1370379
46689039	46689062	16	-	26627737	RPE1	viability after 18 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.16916956881778944	[1200]	[347,381]	1	hSpCas9	negative selection	1370380
46661844	46661867	16	-	26627737	HeLa	viability after 8 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.5955690974888955	[347]	[160,273,235]	5	hSpCas9	negative selection	1452690
46662260	46662283	16	-	26627737	HeLa	viability after 8 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.13360395267844116	[738]	[315,298,270]	-1	hSpCas9	negative selection	1452691
46663081	46663104	16	-	26627737	HeLa	viability after 8 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-0.36315936313665476	[121]	[53,36,35]	-4	hSpCas9	negative selection	1452692
46668959	46668982	16	-	26627737	HeLa	viability after 8 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-0.25996977815528544	[89]	[6,45,38]	-3	hSpCas9	negative selection	1452693
46671740	46671763	16	+	26627737	HeLa	viability after 8 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	-0.24316513535277728	[158]	[48,31,89]	-2	hSpCas9	negative selection	1452694
46689039	46689062	16	-	26627737	HeLa	viability after 8 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.05614148383179207	[619]	[298,346,204]	0	hSpCas9	negative selection	1452695
46661844	46661867	16	-	26627737	HeLa	viability after 12 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.2786319339696248	[347]	[225,125,177]	2	hSpCas9	negative selection	1535005
46662260	46662283	16	-	26627737	HeLa	viability after 12 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.5054555433015073	[738]	[214,218,210]	-4	hSpCas9	negative selection	1535006
46663081	46663104	16	-	26627737	HeLa	viability after 12 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	0.06452377358085282	[121]	[16,53,85]	0	hSpCas9	negative selection	1535007
46668959	46668982	16	-	26627737	HeLa	viability after 12 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-0.583244231466431	[89]	[55,18,0]	-5	hSpCas9	negative selection	1535008
46671740	46671763	16	+	26627737	HeLa	viability after 12 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	-1.345261493081116	[158]	[15,56,0]	-8	hSpCas9	negative selection	1535009
46689039	46689062	16	-	26627737	HeLa	viability after 12 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	-0.1290262354389904	[619]	[196,260,240]	-1	hSpCas9	negative selection	1535010
46661844	46661867	16	-	26627737	HeLa	viability after 15 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.7792804160280931	[347]	[355,176,190]	6	hSpCas9	negative selection	1617320
46662260	46662283	16	-	26627737	HeLa	viability after 15 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.37824069843561015	[738]	[316,244,122]	-3	hSpCas9	negative selection	1617321
46663081	46663104	16	-	26627737	HeLa	viability after 15 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	0.680961874903006	[121]	[70,51,118]	5	hSpCas9	negative selection	1617322
46668959	46668982	16	-	26627737	HeLa	viability after 15 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	0.5579212871213588	[89]	[106,37,12]	4	hSpCas9	negative selection	1617323
46671740	46671763	16	+	26627737	HeLa	viability after 15 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	-0.06441682487391742	[158]	[141,0,39]	0	hSpCas9	negative selection	1617324
46689039	46689062	16	-	26627737	HeLa	viability after 15 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.020587139196292403	[619]	[254,197,319]	0	hSpCas9	negative selection	1617325
46661844	46661867	16	-	26627737	HeLa	viability after 18 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.815687017568018	[347]	[244,153,190]	6	hSpCas9	negative selection	1699635
46662260	46662283	16	-	26627737	HeLa	viability after 18 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.3396365491634423	[738]	[215,213,122]	-3	hSpCas9	negative selection	1699636
46663081	46663104	16	-	26627737	HeLa	viability after 18 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	0.7386201966718465	[121]	[53,42,118]	6	hSpCas9	negative selection	1699637
46668959	46668982	16	-	26627737	HeLa	viability after 18 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	0.646381245853147	[89]	[77,31,12]	5	hSpCas9	negative selection	1699638
46671740	46671763	16	+	26627737	HeLa	viability after 18 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	-0.054147468968309465	[158]	[95,0,39]	0	hSpCas9	negative selection	1699639
46689039	46689062	16	-	26627737	HeLa	viability after 18 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.046266697568002946	[619]	[175,168,319]	0	hSpCas9	negative selection	1699640
46661844	46661867	16	-	26627737	HCT116	viability after 6 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.7786489560855107	[347]	[40,122]	4	hSpCas9	negative selection	1781950
46662260	46662283	16	-	26627737	HCT116	viability after 6 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	0.14942036215225168	[648]	[214,56]	0	hSpCas9	negative selection	1781951
46663081	46663104	16	-	26627737	HCT116	viability after 6 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-1.9787403163702342	[189]	[4,8]	-8	hSpCas9	negative selection	1781952
46668959	46668982	16	-	26627737	HCT116	viability after 6 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-1.495690128303198	[58]	[1,3]	-7	hSpCas9	negative selection	1781953
46671740	46671763	16	+	26627737	HCT116	viability after 6 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	0.25838931324114167	[129]	[17,27]	1	hSpCas9	negative selection	1781954
46689039	46689062	16	-	26627737	HCT116	viability after 6 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	-0.8134427919247552	[1110]	[197,44]	-5	hSpCas9	negative selection	1781955
46661844	46661867	16	-	26627737	HCT116	viability after 8 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	1.1552481668443562	[183]	[204,239,231]	8	hSpCas9	negative selection	1864265
46662260	46662283	16	-	26627737	HCT116	viability after 8 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	0.05281671483351236	[423]	[200,257,266]	0	hSpCas9	negative selection	1864266
46663081	46663104	16	-	26627737	HCT116	viability after 8 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	0.3747237897181459	[153]	[129,136,63]	4	hSpCas9	negative selection	1864267
46668959	46668982	16	-	26627737	HCT116	viability after 8 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	0.34457857312173035	[55]	[26,23,65]	4	hSpCas9	negative selection	1864268
46671740	46671763	16	+	26627737	HCT116	viability after 8 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	0.7121424915680183	[32]	[54,19,14]	6	hSpCas9	negative selection	1864269
46689039	46689062	16	-	26627737	HCT116	viability after 8 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.43841158740810476	[387]	[250,288,327]	4	hSpCas9	negative selection	1864270
46661844	46661867	16	-	26627737	HCT116	viability after 9 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	1.7894472327055877	[347]	[94,499]	9	hSpCas9	negative selection	1946580
46662260	46662283	16	-	26627737	HCT116	viability after 9 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	0.8715411505278667	[648]	[325,309]	6	hSpCas9	negative selection	1946581
46663081	46663104	16	-	26627737	HCT116	viability after 9 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-0.6319389590934694	[189]	[39,26]	-4	hSpCas9	negative selection	1946582
46668959	46668982	16	-	26627737	HCT116	viability after 9 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	2.084161872983514	[58]	[144,4]	9	hSpCas9	negative selection	1946583
46671740	46671763	16	+	26627737	HCT116	viability after 9 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	-0.30538865532730686	[129]	[31,24]	-2	hSpCas9	negative selection	1946584
46689039	46689062	16	-	26627737	HCT116	viability after 9 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	-1.2720420765831038	[1110]	[214,49]	-7	hSpCas9	negative selection	1946585
46661844	46661867	16	-	26627737	HCT116	viability after 12 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.6924653093781552	[183]	[144,164,159]	6	hSpCas9	negative selection	2028895
46662260	46662283	16	-	26627737	HCT116	viability after 12 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.08048437451267354	[423]	[147,263,226]	-1	hSpCas9	negative selection	2028896
46663081	46663104	16	-	26627737	HCT116	viability after 12 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-0.03807255612767735	[153]	[57,148,32]	0	hSpCas9	negative selection	2028897
46668959	46668982	16	-	26627737	HCT116	viability after 12 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-0.4546764953462832	[55]	[11,10,41]	-5	hSpCas9	negative selection	2028898
46671740	46671763	16	+	26627737	HCT116	viability after 12 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	0.47530798241957806	[32]	[36,15,17]	4	hSpCas9	negative selection	2028899
46689039	46689062	16	-	26627737	HCT116	viability after 12 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.5346472310930415	[387]	[200,360,333]	5	hSpCas9	negative selection	2028900
46661844	46661867	16	-	26627737	HCT116	viability after 15 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.567378880349457	[183]	[141,170,154]	5	hSpCas9	negative selection	2111210
46662260	46662283	16	-	26627737	HCT116	viability after 15 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.05713018922128904	[423]	[285,232,189]	0	hSpCas9	negative selection	2111211
46663081	46663104	16	-	26627737	HCT116	viability after 15 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	0.3860240607479535	[153]	[117,194,34]	4	hSpCas9	negative selection	2111212
46668959	46668982	16	-	26627737	HCT116	viability after 15 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-0.4904520064421489	[55]	[40,16,12]	-5	hSpCas9	negative selection	2111213
46671740	46671763	16	+	26627737	HCT116	viability after 15 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	0.3588562473873087	[32]	[24,23,23]	3	hSpCas9	negative selection	2111214
46689039	46689062	16	-	26627737	HCT116	viability after 15 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.3879012239236613	[387]	[294,278,300]	4	hSpCas9	negative selection	2111215
46661844	46661867	16	-	26627737	HCT116	viability after 18 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.6731922181875022	[183]	[62,195,163]	5	hSpCas9	negative selection	2193525
46662260	46662283	16	-	26627737	HCT116	viability after 18 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.23178947772508401	[423]	[155,187,178]	-2	hSpCas9	negative selection	2193526
46663081	46663104	16	-	26627737	HCT116	viability after 18 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	0.07254517757811207	[153]	[30,147,49]	0	hSpCas9	negative selection	2193527
46668959	46668982	16	-	26627737	HCT116	viability after 18 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-2.673997978094228	[55]	[3,1,6]	-9	hSpCas9	negative selection	2193528
46671740	46671763	16	+	26627737	HCT116	viability after 18 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	0.8547747013987621	[32]	[35,4,47]	6	hSpCas9	negative selection	2193529
46689039	46689062	16	-	26627737	HCT116	viability after 18 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.6150395718018911	[387]	[240,253,372]	5	hSpCas9	negative selection	2193530
46689456	46689479	16	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAAGAAGGAATGGAAGGAGGGGG	VPS35	ENSG00000069329	0.7348279431711864	[2,31]	[5,6]	3	dCas9-VP64	positive selection	2443758
46689499	46689522	16	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGCAATCGCCAACGCAGATGCGG	VPS35	ENSG00000069329	1.1339849205037065	[30,11]	[9,9]	4	dCas9-VP64	positive selection	2443759
46689306	46689329	16	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCCTGTCACTTAACGCTAGATGG	VPS35	ENSG00000069329	-1.3788980383009506	[427,434]	[44,25]	-7	dCas9-VP64	positive selection	2449700
46689384	46689407	16	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCAGGGCAGTGGGGATCGCCCGG	VPS35	ENSG00000069329	1.6248028790265487	[216,24]	[145,10]	6	dCas9-VP64	positive selection	2449701
46689334	46689357	16	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGTGAGATTGGCTGGCGCTCAGG	VPS35	ENSG00000069329	0.4801857901293889	[331,69]	[30,92]	2	dCas9-VP64	positive selection	2449702
46689456	46689479	16	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAAGAAGGAATGGAAGGAGGGGG	VPS35	ENSG00000069329	-0.19928352641909908	[87,69]	[17,25]	-2	dCas9-VP64	positive selection	2539013
46689499	46689522	16	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGCAATCGCCAACGCAGATGCGG	VPS35	ENSG00000069329	1.129338006116705	[91,253]	[193,55]	7	dCas9-VP64	positive selection	2539014
46689306	46689329	16	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCCTGTCACTTAACGCTAGATGG	VPS35	ENSG00000069329	-0.4582558115629658	[378,478]	[55,144]	-5	dCas9-VP64	positive selection	2544955
46689384	46689407	16	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCAGGGCAGTGGGGATCGCCCGG	VPS35	ENSG00000069329	0.602423308729277	[218,52]	[62,71]	4	dCas9-VP64	positive selection	2544956
46689334	46689357	16	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGTGAGATTGGCTGGCGCTCAGG	VPS35	ENSG00000069329	0.3856546508845564	[30,30]	[17,7]	3	dCas9-VP64	positive selection	2544957
46674614	46674637	16	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.330301600686173	[2,2]	[0,0]	-9	hSpCas9	positive selection	3031926
46680761	46680784	16	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GATTTGGTAGAAATGTGCCGTGG	VPS35	ENSG00000069329	-0.9281456797881281	[2,3]	[1,0]	-9	hSpCas9	positive selection	3031927
46674614	46674637	16	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.103182236106125	[2,2]	[0,0]	-9	hSpCas9	positive selection	3099784
46680761	46680784	16	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GATTTGGTAGAAATGTGCCGTGG	VPS35	ENSG00000069329	0.25207287992	[2,2]	[3,1]	4	hSpCas9	positive selection	3099785
46683507	46683530		-	24336571	A375	resistance to PLX after 7 days	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	0.22798971534197154	[5,4]	[6,5]	6	hSpCas9	positive selection	3155103
46683504	46683527		+	24336571	A375	resistance to PLX after 7 days	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.2524495147515995	[19,21]	[16,16]	-7	hSpCas9	positive selection	3155104
46681468	46681491		-	24336571	A375	resistance to PLX after 7 days	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	-0.06873970492654247	[24,23]	[22,23]	-2	hSpCas9	positive selection	3155105
46683507	46683530		-	24336571	A375	resistance to PLX after 14 days	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	0.015807334448771027	[6,6]	[2,2]	0	hSpCas9	positive selection	3212896
46683504	46683527		+	24336571	A375	resistance to PLX after 14 days	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-1.3254932679553468	[23,23]	[3,3]	-9	hSpCas9	positive selection	3212897
46681468	46681491		-	24336571	A375	resistance to PLX after 14 days	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	-0.24392329064222895	[15,29]	[9,7]	-3	hSpCas9	positive selection	3212898
46683507	46683530		-	24336571	A375	viability after 7 days	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.17162434924460168	[6]	[5,4]	-2	hSpCas9	negative selection	3270689
46683504	46683527		+	24336571	A375	viability after 7 days	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	0.18008574202595445	[18]	[19,21]	2	hSpCas9	negative selection	3270690
46681468	46681491		-	24336571	A375	viability after 7 days	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.4321840450495878	[18]	[24,23]	6	hSpCas9	negative selection	3270691
46683507	46683530		-	24336571	A375	viability after 14 days	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	0.05172679227132981	[6]	[6,6]	0	hSpCas9	negative selection	3328482
46683504	46683527		+	24336571	A375	viability after 14 days	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	0.4281739302862931	[18]	[23,23]	5	hSpCas9	negative selection	3328483
46681468	46681491		-	24336571	A375	viability after 14 days	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.35308831353978914	[18]	[15,29]	4	hSpCas9	negative selection	3328484
46680683	46680706	16	-	27383988	293T	resistance to West Nile virus (flavivirus)	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	0.5568864933047428	[103,103]	[0,0]	3	hSpCas9	positive selection	3401002
46683504	46683527	16	+	27383988	293T	resistance to West Nile virus (flavivirus)	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.9075807152298527	[286,286]	[0,0]	-6	hSpCas9	positive selection	3401003
46683507	46683530	16	-	27383988	293T	resistance to West Nile virus (flavivirus)	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-1.0187981938284023	[309,309]	[0,0]	-6	hSpCas9	positive selection	3401004
46674614	46674637	16	-	26780180	HT29	viability (Avana library 4 designs)	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	3.44876354485935	[]	[]	9	hSpCas9	negative selection	3471158
46680728	46680751	16	+	26780180	HT29	viability (Avana library 4 designs)	CGAAGAAACAGACCCCTCAAGGG	VPS35	ENSG00000069329	4.7265314581388	[]	[]	9	hSpCas9	negative selection	3471159
46680761	46680784	16	-	26780180	HT29	viability (Avana library 4 designs)	GATTTGGTAGAAATGTGCCGTGG	VPS35	ENSG00000069329	5.75137144474223	[]	[]	9	hSpCas9	negative selection	3471160
46677356	46677379	16	-	26780180	HT29	viability (Avana library 4 designs)	GGAGCAAGTTGTAAACTGTAGGG	VPS35	ENSG00000069329	2.78610988164843	[]	[]	8	hSpCas9	negative selection	3471161
46677356	46677379	16	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGAGCAAGTTGTAAACTGTAGGG	VPS35	ENSG00000069329	0.710355911583841	[]	[]	1	hSpCas9	negative selection	3577825
46680728	46680751	16	+	26780180	A375	viability (Avana lentiCRISPRv2)	CGAAGAAACAGACCCCTCAAGGG	VPS35	ENSG00000069329	-0.791532176550007	[]	[]	-1	hSpCas9	negative selection	3577826
46680761	46680784	16	-	26780180	A375	viability (Avana lentiCRISPRv2)	GATTTGGTAGAAATGTGCCGTGG	VPS35	ENSG00000069329	-4.00998410199362	[]	[]	-4	hSpCas9	negative selection	3577827
46674614	46674637	16	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-4.8646842172046	[]	[]	-5	hSpCas9	negative selection	3577828
46677356	46677379	16	-	26780180	A375	viability (Avana lentiGuide)	GGAGCAAGTTGTAAACTGTAGGG	VPS35	ENSG00000069329	7.15610523210889	[]	[]	5	hSpCas9	negative selection	3686484
46680728	46680751	16	+	26780180	A375	viability (Avana lentiGuide)	CGAAGAAACAGACCCCTCAAGGG	VPS35	ENSG00000069329	9.33609977291026	[]	[]	6	hSpCas9	negative selection	3686485
46680761	46680784	16	-	26780180	A375	viability (Avana lentiGuide)	GATTTGGTAGAAATGTGCCGTGG	VPS35	ENSG00000069329	15.1520100454518	[]	[]	8	hSpCas9	negative selection	3686486
46674614	46674637	16	-	26780180	A375	viability (Avana lentiGuide)	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	13.192448388709	[]	[]	7	hSpCas9	negative selection	3686487
46677356	46677379	16	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGAGCAAGTTGTAAACTGTAGGG	VPS35	ENSG00000069329	-0.08510467678381187	[5]	[4,4]	-1	hSpCas9	positive selection	3795091
46680728	46680751	16	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CGAAGAAACAGACCCCTCAAGGG	VPS35	ENSG00000069329	-0.6577217888797231	[4]	[4,0]	-7	hSpCas9	positive selection	3795092
46680761	46680784	16	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GATTTGGTAGAAATGTGCCGTGG	VPS35	ENSG00000069329	-0.14603504334727743	[5]	[5,4]	-2	hSpCas9	positive selection	3795093
46674614	46674637	16	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-0.3477896869170872	[4]	[4,2]	-5	hSpCas9	positive selection	3795094
46677356	46677379	16	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGAGCAAGTTGTAAACTGTAGGG	VPS35	ENSG00000069329	0.06091687472604748	[4]	[4,2]	1	hSpCas9	positive selection	3903698
46680728	46680751	16	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CGAAGAAACAGACCCCTCAAGGG	VPS35	ENSG00000069329	-1.050074075489874	[4]	[2,0]	-8	hSpCas9	positive selection	3903699
46680761	46680784	16	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GATTTGGTAGAAATGTGCCGTGG	VPS35	ENSG00000069329	-1.0242173893509587	[5]	[0,2]	-8	hSpCas9	positive selection	3903700
46674614	46674637	16	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-0.3233343180783164	[4]	[3,1]	-4	hSpCas9	positive selection	3903701
46680683	46680706	16	-	26780180	A375	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	1.51859311243665	[]	[]	8	hSpCas9	negative selection	4011764
46683507	46683530	16	-	26780180	A375	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	1.72109871429155	[]	[]	9	hSpCas9	negative selection	4011765
46681472	46681495	16	+	26780180	A375	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	0.790802849684059	[]	[]	3	hSpCas9	negative selection	4011766
46680799	46680822	16	-	26780180	A375	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	1.86727129559727	[]	[]	9	hSpCas9	negative selection	4011767
46683504	46683527	16	+	26780180	A375	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	0.857540281698211	[]	[]	3	hSpCas9	negative selection	4011768
46681468	46681491	16	-	26780180	A375	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	-0.0923518289566542	[]	[]	-3	hSpCas9	negative selection	4011769
46680683	46680706	16	-	26780180	HT29	viability (GeCKOv2 library)	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	1.70280529809164	[]	[]	8	hSpCas9	negative selection	4119730
46683507	46683530	16	-	26780180	HT29	viability (GeCKOv2 library)	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	3.36198933837977	[]	[]	9	hSpCas9	negative selection	4119731
46681472	46681495	16	+	26780180	HT29	viability (GeCKOv2 library)	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	0.873925039331714	[]	[]	3	hSpCas9	negative selection	4119732
46680799	46680822	16	-	26780180	HT29	viability (GeCKOv2 library)	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	2.20140044925628	[]	[]	9	hSpCas9	negative selection	4119733
46683504	46683527	16	+	26780180	HT29	viability (GeCKOv2 library)	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	1.77550697302663	[]	[]	8	hSpCas9	negative selection	4119734
46681468	46681491	16	-	26780180	HT29	viability (GeCKOv2 library)	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	-0.147516779716096	[]	[]	-4	hSpCas9	negative selection	4119735
46683507	46683530	16	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.35539099333623225	[3]	[1,1]	-7	hSpCas9	positive selection	4181855
46683504	46683527	16	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.09303775171228854	[4]	[2,1]	-2	hSpCas9	positive selection	4181856
46681468	46681491	16	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	-0.09536872317425205	[4]	[1,3]	-2	hSpCas9	positive selection	4181857
46683507	46683530	16	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.530219082709169	[3]	[0,0,1,0]	-7	hSpCas9	positive selection	4245877
46683504	46683527	16	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	0.9335969216056015	[4]	[3,4,0,3]	6	hSpCas9	positive selection	4245878
46681468	46681491	16	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	1.0961832267801408	[4]	[2,2,2,4]	8	hSpCas9	positive selection	4245879
46681468	46681491	16	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.35697670184768027	[4]	[5,4]	7	hSpCas9	positive selection	4307387
46681472	46681495	16	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	0.26885021510979845	[1]	[1,1]	5	hSpCas9	positive selection	4307388
46680799	46680822	16	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.10486235810746747	[4]	[3,2]	-2	hSpCas9	positive selection	4307389
46680683	46680706	16	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.5252809248716745	[2]	[1,0]	-8	hSpCas9	positive selection	4371635
46683504	46683527	16	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.0743696952617923	[3]	[4,1]	-1	hSpCas9	positive selection	4371636
46683507	46683530	16	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.4885779235714204	[3]	[3,0]	-8	hSpCas9	positive selection	4371637
46678942	46678964	16	-	27760321	OCIAML3	viability	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	-4.303398581904751	[22,26]	[0,0]	-9	hSpCas9	negative selection	4453421
46680833	46680855	16	-	27760321	OCIAML3	viability	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	0.19275160853057716	[250,285]	[291,176]	2	hSpCas9	negative selection	4453422
46674367	46674389	16	+	27760321	OCIAML3	viability	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-2.5489634598875233	[307,233]	[18,57]	-9	hSpCas9	negative selection	4453423
46674631	46674653	16	-	27760321	OCIAML3	viability	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	0.8370664429662821	[373,318]	[439,537]	8	hSpCas9	negative selection	4453424
46676622	46676644	16	+	27760321	OCIAML3	viability	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-1.1581750130222428	[601,502]	[138,262]	-8	hSpCas9	negative selection	4453425
46678942	46678964	16	-	27760321	OCIAML2	viability	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	-0.1331763227909688	[22,26]	[31,0]	-2	hSpCas9	negative selection	4536884
46680833	46680855	16	-	27760321	OCIAML2	viability	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	0.46345464367523537	[250,285]	[248,371]	6	hSpCas9	negative selection	4536885
46674367	46674389	16	+	27760321	OCIAML2	viability	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-0.3280112423313283	[307,233]	[155,195]	-4	hSpCas9	negative selection	4536886
46674631	46674653	16	-	27760321	OCIAML2	viability	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	-0.036768016288319716	[373,318]	[280,260]	0	hSpCas9	negative selection	4536887
46676622	46676644	16	+	27760321	OCIAML2	viability	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-0.8036913373391924	[601,502]	[232,283]	-7	hSpCas9	negative selection	4536888
46678942	46678964	16	-	27760321	MV411	viability	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	0.24797221769243727	[22,26]	[0,47]	1	hSpCas9	negative selection	4620347
46680833	46680855	16	-	27760321	MV411	viability	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	1.2303596814095514	[250,285]	[547,225]	8	hSpCas9	negative selection	4620348
46674367	46674389	16	+	27760321	MV411	viability	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-2.816363775861038	[307,233]	[9,47]	-9	hSpCas9	negative selection	4620349
46674631	46674653	16	-	27760321	MV411	viability	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	0.160740685745542	[373,318]	[229,291]	1	hSpCas9	negative selection	4620350
46676622	46676644	16	+	27760321	MV411	viability	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-0.37815836263517033	[601,502]	[19,668]	-3	hSpCas9	negative selection	4620351
46678942	46678964	16	-	27760321	HL60	viability	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	-2.5893373411239455	[22,26]	[0,5]	-9	hSpCas9	negative selection	4703810
46680833	46680855	16	-	27760321	HL60	viability	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	0.6282501487751454	[250,285]	[306,378]	7	hSpCas9	negative selection	4703811
46674367	46674389	16	+	27760321	HL60	viability	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-1.070667556380862	[307,233]	[89,119]	-8	hSpCas9	negative selection	4703812
46674631	46674653	16	-	27760321	HL60	viability	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	0.43350774067141906	[373,318]	[414,344]	5	hSpCas9	negative selection	4703813
46676622	46676644	16	+	27760321	HL60	viability	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-0.7339368888152015	[601,502]	[311,225]	-6	hSpCas9	negative selection	4703814
46678942	46678964	16	-	27760321	HT1080	viability	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	2.008054421640905	[26,20]	[68,4]	9	hSpCas9	negative selection	4787273
46680833	46680855	16	-	27760321	HT1080	viability	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	-6.100606186761894	[285,222]	[0,1]	-9	hSpCas9	negative selection	4787274
46674367	46674389	16	+	27760321	HT1080	viability	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-6.3762680060592185	[233,182]	[0,0]	-9	hSpCas9	negative selection	4787275
46674631	46674653	16	-	27760321	HT1080	viability	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	-1.659295871532636	[318,248]	[31,39]	-5	hSpCas9	negative selection	4787276
46676622	46676644	16	+	27760321	HT1080	viability	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-1.419861795708265	[502,392]	[49,84]	-5	hSpCas9	negative selection	4787277
46678942	46678964	16	-	27760321	HT29	viability after 7 days	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	-1.2279922315907328	[26,20]	[34,6,0]	-9	hSpCas9	negative selection	4870736
46680833	46680855	16	-	27760321	HT29	viability after 7 days	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	-0.790313160428963	[285,222]	[267,167,143]	-8	hSpCas9	negative selection	4870737
46674367	46674389	16	+	27760321	HT29	viability after 7 days	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-0.38291772790893785	[233,182]	[185,71,350]	-5	hSpCas9	negative selection	4870738
46674631	46674653	16	-	27760321	HT29	viability after 7 days	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	-0.5690380125233451	[318,248]	[361,223,170]	-7	hSpCas9	negative selection	4870739
46676622	46676644	16	+	27760321	HT29	viability after 7 days	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-0.8498799119275529	[502,392]	[327,389,243]	-8	hSpCas9	negative selection	4870740
46678942	46678964	16	-	27760321	HT29	viability after 25 days	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	-4.776519925696908	[26,20]	[0,0,0]	-9	hSpCas9	negative selection	4954199
46680833	46680855	16	-	27760321	HT29	viability after 25 days	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	-0.39667350581519717	[285,222]	[199,162,309]	-4	hSpCas9	negative selection	4954200
46674367	46674389	16	+	27760321	HT29	viability after 25 days	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-2.5672262195704643	[233,182]	[17,28,78]	-8	hSpCas9	negative selection	4954201
46674631	46674653	16	-	27760321	HT29	viability after 25 days	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	-2.1168964389630487	[318,248]	[40,45,146]	-8	hSpCas9	negative selection	4954202
46676622	46676644	16	+	27760321	HT29	viability after 25 days	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-4.623138734580373	[502,392]	[0,11,53]	-9	hSpCas9	negative selection	4954203
46678942	46678964	16	-	27760321	HT29	viability after 22 days	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	-4.3712271973147345	[26,20]	[1,0,0]	-9	hSpCas9	negative selection	5037662
46680833	46680855	16	-	27760321	HT29	viability after 22 days	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	-0.3071445792093305	[285,222]	[213,259,239]	-3	hSpCas9	negative selection	5037663
46674367	46674389	16	+	27760321	HT29	viability after 22 days	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-2.8313607744444598	[233,182]	[0,14,86]	-8	hSpCas9	negative selection	5037664
46674631	46674653	16	-	27760321	HT29	viability after 22 days	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	-2.1899993614860005	[318,248]	[1,116,98]	-8	hSpCas9	negative selection	5037665
46676622	46676644	16	+	27760321	HT29	viability after 22 days	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-3.8221594706715654	[502,392]	[37,15,55]	-9	hSpCas9	negative selection	5037666
46678942	46678964	16	-	27760321	HT29	viability after 19 days	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	-3.627059924029492	[26,20]	[4,0,0]	-9	hSpCas9	negative selection	5121125
46680833	46680855	16	-	27760321	HT29	viability after 19 days	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	0.028662509009523662	[285,222]	[368,338,193]	0	hSpCas9	negative selection	5121126
46674367	46674389	16	+	27760321	HT29	viability after 19 days	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-3.1109164600360755	[233,182]	[29,50,2]	-8	hSpCas9	negative selection	5121127
46674631	46674653	16	-	27760321	HT29	viability after 19 days	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	-1.890968914365802	[318,248]	[107,127,30]	-8	hSpCas9	negative selection	5121128
46676622	46676644	16	+	27760321	HT29	viability after 19 days	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-4.798821903061772	[502,392]	[5,4,41]	-9	hSpCas9	negative selection	5121129
46678942	46678964	16	-	27760321	HT29	viability after 16 days	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	-3.139316776466197	[26,20]	[0,0,6]	-9	hSpCas9	negative selection	5204588
46680833	46680855	16	-	27760321	HT29	viability after 16 days	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	-0.2646363676268642	[285,222]	[174,202,327]	-3	hSpCas9	negative selection	5204589
46674367	46674389	16	+	27760321	HT29	viability after 16 days	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-1.8401810352697834	[233,182]	[108,49,40]	-8	hSpCas9	negative selection	5204590
46674631	46674653	16	-	27760321	HT29	viability after 16 days	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	-1.0179637369875698	[318,248]	[55,162,241]	-7	hSpCas9	negative selection	5204591
46676622	46676644	16	+	27760321	HT29	viability after 16 days	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-3.7281825666354034	[502,392]	[81,23,11]	-9	hSpCas9	negative selection	5204592
46678942	46678964	16	-	27760321	HT29	viability after 13 days	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	-0.8858110545247619	[26,20]	[43,0,0]	-7	hSpCas9	negative selection	5288051
46680833	46680855	16	-	27760321	HT29	viability after 13 days	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	-0.12225325890282085	[285,222]	[245,300,266]	-1	hSpCas9	negative selection	5288052
46674367	46674389	16	+	27760321	HT29	viability after 13 days	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-1.7808782436874346	[233,182]	[2,63,139]	-8	hSpCas9	negative selection	5288053
46674631	46674653	16	-	27760321	HT29	viability after 13 days	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	-1.6133820490811797	[318,248]	[108,122,91]	-8	hSpCas9	negative selection	5288054
46676622	46676644	16	+	27760321	HT29	viability after 13 days	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-2.286978291897744	[502,392]	[137,101,80]	-9	hSpCas9	negative selection	5288055
46678942	46678964	16	-	27760321	HT29	viability after 10 days	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	-2.229324267631763	[26,20]	[10,0,6]	-9	hSpCas9	negative selection	5371514
46680833	46680855	16	-	27760321	HT29	viability after 10 days	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	-0.16184958088528484	[285,222]	[325,264,260]	-2	hSpCas9	negative selection	5371515
46674367	46674389	16	+	27760321	HT29	viability after 10 days	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-0.39160119357660494	[233,182]	[204,67,315]	-5	hSpCas9	negative selection	5371516
46674631	46674653	16	-	27760321	HT29	viability after 10 days	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	-1.2288265130800542	[318,248]	[155,71,221]	-8	hSpCas9	negative selection	5371517
46676622	46676644	16	+	27760321	HT29	viability after 10 days	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-1.5650203746043738	[502,392]	[202,219,145]	-8	hSpCas9	negative selection	5371518
46678942	46678964	16	-	27760321	MOLM13	viability	AATGTGGAACGTTACAAACAGG	VPS35	ENSG00000069329	-3.8322632001624735	[22,26]	[0,0]	-9	hSpCas9	negative selection	5454977
46680833	46680855	16	-	27760321	MOLM13	viability	GTTACCTTTTGATCACAGTTGG	VPS35	ENSG00000069329	0.7433653766260644	[250,285]	[224,281]	5	hSpCas9	negative selection	5454978
46674367	46674389	16	+	27760321	MOLM13	viability	AACATAGTCCACACGATCAGGG	VPS35	ENSG00000069329	-3.016504679706964	[307,233]	[1,32]	-9	hSpCas9	negative selection	5454979
46674631	46674653	16	-	27760321	MOLM13	viability	TATTTGCTCACCGTGAAGATGG	VPS35	ENSG00000069329	1.9636700510101126	[373,318]	[1619,27]	9	hSpCas9	negative selection	5454980
46676622	46676644	16	+	27760321	MOLM13	viability	TTCTGGTGTAACTCAGCACAGG	VPS35	ENSG00000069329	-3.8453588698884382	[601,502]	[26,16]	-9	hSpCas9	negative selection	5454981
46688673	46688696	16	+	27661255	K562	viability	GGGGACGGCCGAGCACAACTAGG	VPS35	ENSG00000069329	-0.6836812989931064	[291,527]	[224,181]	-8	dCas9-KRAB	negative selection	5522289
46688731	46688754	16	+	27661255	K562	viability	GGCGCCACCTCCGAGTCTCAGGG	VPS35	ENSG00000069329	-0.5837978568727463	[802,949]	[536,404]	-8	dCas9-KRAB	negative selection	5522290
46689084	46689107	16	+	27661255	K562	viability	GCTACAAGGAGGGTCGACCCAGG	VPS35	ENSG00000069329	-1.1528209594644563	[505,625]	[194,208]	-8	dCas9-KRAB	negative selection	5522291
46689141	46689164	16	-	27661255	K562	viability	GCTGCTTGCTGCAGGCTCTGGGG	VPS35	ENSG00000069329	-2.7264454136857315	[36,61]	[6,4]	-9	dCas9-KRAB	negative selection	5522292
46681468	46681491	16	-	27260156	BXPC3	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.35167160408604103	[1808]	[1948,2485,2589,2696]	7	hSpCas9	negative selection	5579847
46681472	46681495	16	+	27260156	BXPC3	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.5576898227450071	[86]	[38,78,54,76]	-8	hSpCas9	negative selection	5579848
46680799	46680822	16	-	27260156	BXPC3	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.5408666699197626	[1027]	[652,829,696,777]	-8	hSpCas9	negative selection	5579849
46680683	46680706	16	-	27260156	BXPC3	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	0.09203525537875706	[345]	[370,332,345,508]	2	hSpCas9	negative selection	5644095
46683504	46683527	16	+	27260156	BXPC3	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.2832825233666315	[974]	[713,763,692,1238]	-6	hSpCas9	negative selection	5644096
46683507	46683530	16	-	27260156	BXPC3	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.23960747846939645	[947]	[745,854,863,904]	-5	hSpCas9	negative selection	5644097
46681468	46681491	16	-	27260156	A673	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.30758036890965745	[1808]	[2900,2526,2583,2769]	7	hSpCas9	negative selection	5701098
46681472	46681495	16	+	27260156	A673	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.05209258501493608	[86]	[122,97,92,90]	-1	hSpCas9	negative selection	5701099
46680799	46680822	16	-	27260156	A673	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.28005380140217806	[1027]	[1261,908,898,1026]	-6	hSpCas9	negative selection	5701100
46680683	46680706	16	-	27260156	A673	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.29467088321804635	[345]	[492,279,366,226]	-6	hSpCas9	negative selection	5765346
46683504	46683527	16	+	27260156	A673	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.22937966396929577	[974]	[1111,910,1014,967]	-5	hSpCas9	negative selection	5765347
46683507	46683530	16	-	27260156	A673	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.28243006047870167	[947]	[969,953,953,862]	-6	hSpCas9	negative selection	5765348
46681468	46681491	16	-	27260156	A375	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.5960340056221567	[1808]	[2919,3827,3389,2762]	8	hSpCas9	negative selection	5822349
46681472	46681495	16	+	27260156	A375	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-2.0052393258555314	[86]	[37,31,32,1]	-9	hSpCas9	negative selection	5822350
46680799	46680822	16	-	27260156	A375	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.5714536642217062	[1027]	[799,1115,763,614]	-6	hSpCas9	negative selection	5822351
46680683	46680706	16	-	27260156	A375	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.6835697136798842	[345]	[348,293,245,136]	-7	hSpCas9	negative selection	5886597
46683504	46683527	16	+	27260156	A375	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.09734963534410257	[974]	[1121,1066,1263,829]	-1	hSpCas9	negative selection	5886598
46683507	46683530	16	-	27260156	A375	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.6073787423208156	[947]	[718,656,721,788]	-7	hSpCas9	negative selection	5886599
46681468	46681491	16	-	27260156	COLO741	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.3199748782044949	[1808]	[3147,2969,2576]	6	hSpCas9	negative selection	5943600
46681472	46681495	16	+	27260156	COLO741	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.5417548526681673	[86]	[76,103,49]	-8	hSpCas9	negative selection	5943601
46680799	46680822	16	-	27260156	COLO741	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.481456639549827	[1027]	[908,1000,909]	-8	hSpCas9	negative selection	5943602
46680683	46680706	16	-	27260156	COLO741	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.6315464562390909	[345]	[313,288,256]	-8	hSpCas9	negative selection	6007848
46683504	46683527	16	+	27260156	COLO741	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.4640462809400099	[974]	[1053,862,809]	-7	hSpCas9	negative selection	6007849
46683507	46683530	16	-	27260156	COLO741	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.5573920409361505	[947]	[1148,530,814]	-8	hSpCas9	negative selection	6007850
46681468	46681491	16	-	27260156	CAL120	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.4143209692890635	[1808]	[3180,3576,2280]	6	hSpCas9	negative selection	6064851
46681472	46681495	16	+	27260156	CAL120	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.27351257901534076	[86]	[84,94,87]	-4	hSpCas9	negative selection	6064852
46680799	46680822	16	-	27260156	CAL120	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.5335983567770304	[1027]	[1023,935,714]	-6	hSpCas9	negative selection	6064853
46680683	46680706	16	-	27260156	CAL120	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.4340359679469423	[345]	[454,288,233]	-6	hSpCas9	negative selection	6129099
46683504	46683527	16	+	27260156	CAL120	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.3185041838864552	[974]	[997,1333,596]	-5	hSpCas9	negative selection	6129100
46683507	46683530	16	-	27260156	CAL120	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.28850633363923806	[947]	[703,1199,953]	-4	hSpCas9	negative selection	6129101
46681468	46681491	16	-	27260156	CADOES1	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.4321383039326061	[1808]	[2239,2073,2490,2274]	7	hSpCas9	negative selection	6186102
46681472	46681495	16	+	27260156	CADOES1	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.035970868684662705	[86]	[129,58,60,64]	0	hSpCas9	negative selection	6186103
46680799	46680822	16	-	27260156	CADOES1	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.20078187570951456	[1027]	[865,1011,639,808]	-3	hSpCas9	negative selection	6186104
46680683	46680706	16	-	27260156	CADOES1	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.43608128904950805	[345]	[225,203,241,280]	-6	hSpCas9	negative selection	6250350
46683504	46683527	16	+	27260156	CADOES1	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.30790814054117155	[974]	[678,863,566,823]	-5	hSpCas9	negative selection	6250351
46683507	46683530	16	-	27260156	CADOES1	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.21351933732734807	[947]	[838,689,732,779]	-4	hSpCas9	negative selection	6250352
46681468	46681491	16	-	27260156	EWS502	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.509714386119837	[1808]	[2255,3137,2697,2858]	8	hSpCas9	negative selection	6307353
46681472	46681495	16	+	27260156	EWS502	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.756245227393014	[86]	[61,40,71,41]	-8	hSpCas9	negative selection	6307354
46680799	46680822	16	-	27260156	EWS502	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.17735471683368742	[1027]	[851,969,1230,799]	-3	hSpCas9	negative selection	6307355
46680683	46680706	16	-	27260156	EWS502	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.15627630963041605	[345]	[233,351,295,450]	-3	hSpCas9	negative selection	6371601
46683504	46683527	16	+	27260156	EWS502	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.007993013460167342	[974]	[895,836,1314,1087]	0	hSpCas9	negative selection	6371602
46683507	46683530	16	-	27260156	EWS502	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	0.025980996781621357	[947]	[1086,1009,799,1189]	0	hSpCas9	negative selection	6371603
46681468	46681491	16	-	27260156	EW8	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.37873440415291015	[1808]	[2341,2002,1503,1886]	7	hSpCas9	negative selection	6428604
46681472	46681495	16	+	27260156	EW8	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.12476793928240282	[86]	[61,49,88,52]	-2	hSpCas9	negative selection	6428605
46680799	46680822	16	-	27260156	EW8	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.3581150638460572	[1027]	[695,753,517,657]	-6	hSpCas9	negative selection	6428606
46680683	46680706	16	-	27260156	EW8	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.2677122935012938	[345]	[261,136,205,332]	-5	hSpCas9	negative selection	6492852
46683504	46683527	16	+	27260156	EW8	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.21463085267227433	[974]	[746,636,571,790]	-4	hSpCas9	negative selection	6492853
46683507	46683530	16	-	27260156	EW8	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.19678506520691075	[947]	[590,662,731,673]	-4	hSpCas9	negative selection	6492854
46681468	46681491	16	-	27260156	CORL105	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.40303201429977453	[1808]	[2847,2732,3268,2427]	7	hSpCas9	negative selection	6549855
46681472	46681495	16	+	27260156	CORL105	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.48704393193556283	[86]	[106,60,52,67]	-7	hSpCas9	negative selection	6549856
46680799	46680822	16	-	27260156	CORL105	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.05767675230626912	[1027]	[777,1208,1559,1126]	-1	hSpCas9	negative selection	6549857
46680683	46680706	16	-	27260156	CORL105	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.6771095286226005	[345]	[329,211,291,188]	-8	hSpCas9	negative selection	6614103
46683504	46683527	16	+	27260156	CORL105	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.28174072187083277	[974]	[870,920,994,974]	-5	hSpCas9	negative selection	6614104
46683507	46683530	16	-	27260156	CORL105	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.26302357032175094	[947]	[886,894,1161,791]	-5	hSpCas9	negative selection	6614105
46681468	46681491	16	-	27260156	HS294T	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.8596788153038124	[1808]	[1144,987,1424,1589]	9	hSpCas9	negative selection	6671106
46681472	46681495	16	+	27260156	HS294T	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.554981022504268	[86]	[10,8,35,39]	-7	hSpCas9	negative selection	6671107
46680799	46680822	16	-	27260156	HS294T	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.33834602039854644	[1027]	[211,354,358,343]	-5	hSpCas9	negative selection	6671108
46680683	46680706	16	-	27260156	HS294T	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.5382510616850317	[345]	[70,112,70,118]	-6	hSpCas9	negative selection	6735354
46683504	46683527	16	+	27260156	HS294T	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.32282588366191634	[974]	[280,262,336,331]	-4	hSpCas9	negative selection	6735355
46683507	46683530	16	-	27260156	HS294T	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.0912144744585508	[947]	[265,371,338,416]	-1	hSpCas9	negative selection	6735356
46681468	46681491	16	-	27260156	HCC44	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.16711241888029638	[1808]	[2273,2124,2718,2151]	2	hSpCas9	negative selection	6792357
46681472	46681495	16	+	27260156	HCC44	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.2896744109376068	[86]	[114,57,65,85]	-4	hSpCas9	negative selection	6792358
46680799	46680822	16	-	27260156	HCC44	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.6646016203464916	[1027]	[659,721,1172,452]	-7	hSpCas9	negative selection	6792359
46680683	46680706	16	-	27260156	HCC44	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.9490241409759697	[345]	[108,212,233,246]	-8	hSpCas9	negative selection	6856605
46683504	46683527	16	+	27260156	HCC44	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	0.13036299864978362	[974]	[1151,1253,1393,1043]	2	hSpCas9	negative selection	6856606
46683507	46683530	16	-	27260156	HCC44	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.14823498666056156	[947]	[1120,931,969,861]	-2	hSpCas9	negative selection	6856607
46681468	46681491	16	-	27260156	G402	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.8118476688140743	[1808]	[4255,4255,3858,3222]	8	hSpCas9	negative selection	6913608
46681472	46681495	16	+	27260156	G402	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-1.0721923346599822	[86]	[57,76,31,37]	-8	hSpCas9	negative selection	6913609
46680799	46680822	16	-	27260156	G402	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.18198211401329834	[1027]	[966,1308,1296,849]	-2	hSpCas9	negative selection	6913610
46680683	46680706	16	-	27260156	G402	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	0.015346172338068342	[345]	[234,431,291,704]	0	hSpCas9	negative selection	6977856
46683504	46683527	16	+	27260156	G402	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	0.09880153143878467	[974]	[1420,1610,1398,727]	1	hSpCas9	negative selection	6977857
46683507	46683530	16	-	27260156	G402	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.16945423980399787	[947]	[1003,845,1448,807]	-2	hSpCas9	negative selection	6977858
46681468	46681491	16	-	27260156	L33	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.34973247285448417	[1808]	[2455,890,1387,2376]	7	hSpCas9	negative selection	7034859
46681472	46681495	16	+	27260156	L33	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	0.6723871316915127	[86]	[120,46,108,145]	9	hSpCas9	negative selection	7034860
46680799	46680822	16	-	27260156	L33	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.16166691106278808	[1027]	[955,404,556,844]	-4	hSpCas9	negative selection	7034861
46680683	46680706	16	-	27260156	L33	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.31317624742835026	[345]	[261,108,168,316]	-6	hSpCas9	negative selection	7099107
46683504	46683527	16	+	27260156	L33	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.17835977345863008	[974]	[786,387,527,873]	-4	hSpCas9	negative selection	7099108
46683507	46683530	16	-	27260156	L33	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.14849816815031947	[947]	[790,372,562,825]	-3	hSpCas9	negative selection	7099109
46681468	46681491	16	-	27260156	K562	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.433193402280464	[1808]	[2796,2153,1952,1845]	5	hSpCas9	negative selection	7156110
46681472	46681495	16	+	27260156	K562	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-1.5209663853546393	[86]	[6,28,14,51]	-9	hSpCas9	negative selection	7156111
46680799	46680822	16	-	27260156	K562	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.3358354421688535	[1027]	[714,734,873,580]	-4	hSpCas9	negative selection	7156112
46680683	46680706	16	-	27260156	K562	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.5099273468868326	[345]	[264,300,143,165]	-6	hSpCas9	negative selection	7220358
46683504	46683527	16	+	27260156	K562	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	0.052538158670451196	[974]	[978,1337,680,646]	0	hSpCas9	negative selection	7220359
46683507	46683530	16	-	27260156	K562	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.210467607476707	[947]	[1185,583,727,467]	-3	hSpCas9	negative selection	7220360
46681468	46681491	16	-	27260156	HT29	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.5039639829973213	[1808]	[2816,3740,3348,2634]	8	hSpCas9	negative selection	7277361
46681472	46681495	16	+	27260156	HT29	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.3732798268055437	[86]	[81,174,30,49]	-6	hSpCas9	negative selection	7277362
46680799	46680822	16	-	27260156	HT29	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.3541425554538642	[1027]	[1082,937,1024,874]	-6	hSpCas9	negative selection	7277363
46680683	46680706	16	-	27260156	HT29	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.5997657239755623	[345]	[248,281,276,295]	-7	hSpCas9	negative selection	7341609
46683504	46683527	16	+	27260156	HT29	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.3411187257193997	[974]	[1114,889,933,820]	-6	hSpCas9	negative selection	7341610
46683507	46683530	16	-	27260156	HT29	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.42024856116647025	[947]	[964,884,786,816]	-6	hSpCas9	negative selection	7341611
46681468	46681491	16	-	27260156	MHHES1	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.43850200588094723	[1808]	[2868,3092,2530,2575]	7	hSpCas9	negative selection	7398612
46681472	46681495	16	+	27260156	MHHES1	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.42251803560645307	[86]	[125,48,53,66]	-7	hSpCas9	negative selection	7398613
46680799	46680822	16	-	27260156	MHHES1	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.012156885083778324	[1027]	[1154,1420,1003,1038]	0	hSpCas9	negative selection	7398614
46680683	46680706	16	-	27260156	MHHES1	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.32292548685456046	[345]	[398,228,341,278]	-6	hSpCas9	negative selection	7462860
46683504	46683527	16	+	27260156	MHHES1	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.12264812646005119	[974]	[1002,1554,959,635]	-2	hSpCas9	negative selection	7462861
46683507	46683530	16	-	27260156	MHHES1	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.2856228965731674	[947]	[784,832,1148,735]	-5	hSpCas9	negative selection	7462862
46681468	46681491	16	-	27260156	MEWO	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.17812804472267785	[1808]	[2145,1890,1751]	4	hSpCas9	negative selection	7519863
46681472	46681495	16	+	27260156	MEWO	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	0.15382763531487287	[86]	[75,52,139]	3	hSpCas9	negative selection	7519864
46680799	46680822	16	-	27260156	MEWO	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.518693674550741	[1027]	[896,569,590]	-8	hSpCas9	negative selection	7519865
46680683	46680706	16	-	27260156	MEWO	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.7373855425706388	[345]	[263,190,140]	-9	hSpCas9	negative selection	7584111
46683504	46683527	16	+	27260156	MEWO	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.409712067971188	[974]	[804,635,641]	-7	hSpCas9	negative selection	7584112
46683507	46683530	16	-	27260156	MEWO	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.3427043441224935	[947]	[762,765,580]	-6	hSpCas9	negative selection	7584113
46681468	46681491	16	-	27260156	LNCAPCLONEFGC	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.4965179750000501	[1808]	[2038,2095,2604,2568]	7	hSpCas9	negative selection	7641114
46681472	46681495	16	+	27260156	LNCAPCLONEFGC	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.17387840251149633	[86]	[70,76,83,48]	-3	hSpCas9	negative selection	7641115
46680799	46680822	16	-	27260156	LNCAPCLONEFGC	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.6238431106117944	[1027]	[560,721,584,538]	-7	hSpCas9	negative selection	7641116
46680683	46680706	16	-	27260156	LNCAPCLONEFGC	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.5719038344130856	[345]	[132,189,256,272]	-7	hSpCas9	negative selection	7705362
46683504	46683527	16	+	27260156	LNCAPCLONEFGC	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.28569254237350694	[974]	[746,708,796,655]	-4	hSpCas9	negative selection	7705363
46683507	46683530	16	-	27260156	LNCAPCLONEFGC	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.22904685420649473	[947]	[558,663,953,793]	-4	hSpCas9	negative selection	7705364
46681468	46681491	16	-	27260156	PANC0327	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.541998362578737	[1808]	[2618,1899,2511,2406]	7	hSpCas9	negative selection	7762365
46681472	46681495	16	+	27260156	PANC0327	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	0.661259264046173	[86]	[101,199,41,132]	8	hSpCas9	negative selection	7762366
46680799	46680822	16	-	27260156	PANC0327	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.7519521468977284	[1027]	[588,341,379,886]	-8	hSpCas9	negative selection	7762367
46680683	46680706	16	-	27260156	PANC0327	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.4683718869154546	[345]	[311,74,289,237]	-6	hSpCas9	negative selection	7826613
46683504	46683527	16	+	27260156	PANC0327	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.47798080606713567	[974]	[630,440,555,882]	-6	hSpCas9	negative selection	7826614
46683507	46683530	16	-	27260156	PANC0327	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.19777973493624545	[947]	[960,792,774,418]	-3	hSpCas9	negative selection	7826615
46681468	46681491	16	-	27260156	NCIH2009	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.7309627888141217	[1808]	[5117,3816,3831]	8	hSpCas9	negative selection	7883616
46681472	46681495	16	+	27260156	NCIH2009	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-1.37681322204983	[86]	[89,39,18]	-9	hSpCas9	negative selection	7883617
46680799	46680822	16	-	27260156	NCIH2009	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.31420737896906237	[1027]	[1083,963,1404]	-4	hSpCas9	negative selection	7883618
46680683	46680706	16	-	27260156	NCIH2009	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.8635567983555985	[345]	[374,221,221]	-8	hSpCas9	negative selection	7947864
46683504	46683527	16	+	27260156	NCIH2009	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.5024216412225844	[974]	[1202,958,768]	-6	hSpCas9	negative selection	7947865
46683507	46683530	16	-	27260156	NCIH2009	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.5766289387525281	[947]	[1013,762,912]	-6	hSpCas9	negative selection	7947866
46681468	46681491	16	-	27260156	NCIH1373	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	1.1043629359295017	[1808]	[5963,3711,3862,1102]	9	hSpCas9	negative selection	8004867
46681472	46681495	16	+	27260156	NCIH1373	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-1.4064943264528411	[86]	[53,24,26,11]	-8	hSpCas9	negative selection	8004868
46680799	46680822	16	-	27260156	NCIH1373	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.44718236729071315	[1027]	[912,508,855,305]	-4	hSpCas9	negative selection	8004869
46680683	46680706	16	-	27260156	NCIH1373	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-1.177656211733009	[345]	[141,263,104,41]	-8	hSpCas9	negative selection	8069115
46683504	46683527	16	+	27260156	NCIH1373	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	0.25361987274911835	[974]	[1285,1233,1175,401]	2	hSpCas9	negative selection	8069116
46683507	46683530	16	-	27260156	NCIH1373	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.8394304499052461	[947]	[596,350,564,237]	-7	hSpCas9	negative selection	8069117
46681468	46681491	16	-	27260156	PATU8902	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.7400209615139495	[1808]	[5173,4262,3490,4020]	7	hSpCas9	negative selection	8126118
46681472	46681495	16	+	27260156	PATU8902	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-4.454819337119177	[86]	[1,1,0,19]	-9	hSpCas9	negative selection	8126119
46680799	46680822	16	-	27260156	PATU8902	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.48760107222347426	[1027]	[873,504,1353,1288]	-5	hSpCas9	negative selection	8126120
46680683	46680706	16	-	27260156	PATU8902	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-1.1527659181942482	[345]	[426,253,105,88]	-7	hSpCas9	negative selection	8190366
46683504	46683527	16	+	27260156	PATU8902	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.6574367711174018	[974]	[602,1168,637,1119]	-6	hSpCas9	negative selection	8190367
46683507	46683530	16	-	27260156	PATU8902	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-1.2703917530158757	[947]	[471,833,425,477]	-8	hSpCas9	negative selection	8190368
46681468	46681491	16	-	27260156	PANC1	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.5019548223559951	[1808]	[2074,2519,2595,1724]	7	hSpCas9	negative selection	8247369
46681472	46681495	16	+	27260156	PANC1	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.8967422154612281	[86]	[38,57,29,36]	-8	hSpCas9	negative selection	8247370
46680799	46680822	16	-	27260156	PANC1	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.024647477732113288	[1027]	[797,1018,1085,628]	0	hSpCas9	negative selection	8247371
46680683	46680706	16	-	27260156	PANC1	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.24168119391108123	[345]	[231,411,186,209]	-4	hSpCas9	negative selection	8311617
46683504	46683527	16	+	27260156	PANC1	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.05384763276474669	[974]	[794,1063,844,597]	-1	hSpCas9	negative selection	8311618
46683507	46683530	16	-	27260156	PANC1	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	0.02520193082818345	[947]	[837,1101,728,706]	0	hSpCas9	negative selection	8311619
46681468	46681491	16	-	27260156	PANC0813	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.6233629490335979	[1808]	[3347,3349,3068,3323]	8	hSpCas9	negative selection	8368620
46681472	46681495	16	+	27260156	PANC0813	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-1.1403005812596088	[86]	[56,34,75,19]	-9	hSpCas9	negative selection	8368621
46680799	46680822	16	-	27260156	PANC0813	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.482868443408472	[1027]	[1041,1015,502,905]	-6	hSpCas9	negative selection	8368622
46680683	46680706	16	-	27260156	PANC0813	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.4843806955039711	[345]	[219,294,343,295]	-6	hSpCas9	negative selection	8432868
46683504	46683527	16	+	27260156	PANC0813	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.4197159205358293	[974]	[1370,734,759,617]	-6	hSpCas9	negative selection	8432869
46683507	46683530	16	-	27260156	PANC0813	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.7087155982034767	[947]	[773,727,631,602]	-7	hSpCas9	negative selection	8432870
46681468	46681491	16	-	27260156	RDES	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.5580798866782357	[1808]	[2618,2886,3070,3805]	8	hSpCas9	negative selection	8489871
46681472	46681495	16	+	27260156	RDES	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.8017547592690253	[86]	[26,68,40,102]	-8	hSpCas9	negative selection	8489872
46680799	46680822	16	-	27260156	RDES	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	0.011672512671023094	[1027]	[916,1058,1612,1238]	0	hSpCas9	negative selection	8489873
46680683	46680706	16	-	27260156	RDES	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.38592188478534495	[345]	[239,325,346,309]	-6	hSpCas9	negative selection	8554119
46683504	46683527	16	+	27260156	RDES	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.04747520478614353	[974]	[699,1018,1057,1719]	-1	hSpCas9	negative selection	8554120
46683507	46683530	16	-	27260156	RDES	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.05899618875683843	[947]	[718,1102,1202,1230]	-1	hSpCas9	negative selection	8554121
46681468	46681491	16	-	27260156	PC3	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.19872923827967193	[1808]	[1256,1975,3070,2549]	4	hSpCas9	negative selection	8611122
46681472	46681495	16	+	27260156	PC3	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	0.4334377007680521	[86]	[81,112,110,164]	8	hSpCas9	negative selection	8611123
46680799	46680822	16	-	27260156	PC3	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.3956807943643862	[1027]	[556,630,1714,590]	-7	hSpCas9	negative selection	8611124
46680683	46680706	16	-	27260156	PC3	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.5542049101115984	[345]	[196,168,425,211]	-8	hSpCas9	negative selection	8675370
46683504	46683527	16	+	27260156	PC3	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.37714827926639793	[974]	[549,853,1081,626]	-7	hSpCas9	negative selection	8675371
46683507	46683530	16	-	27260156	PC3	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.20540243966993177	[947]	[600,678,1515,763]	-4	hSpCas9	negative selection	8675372
46681468	46681491	16	-	27260156	PATU8988T	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.28736468089242684	[1808]	[2455,2382,1745,1962]	5	hSpCas9	negative selection	8732373
46681472	46681495	16	+	27260156	PATU8988T	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.37825387971512914	[86]	[49,99,49,61]	-6	hSpCas9	negative selection	8732374
46680799	46680822	16	-	27260156	PATU8988T	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.12788097313347935	[1027]	[944,817,974,886]	-2	hSpCas9	negative selection	8732375
46680683	46680706	16	-	27260156	PATU8988T	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.8551149737259893	[345]	[130,133,235,236]	-8	hSpCas9	negative selection	8796621
46683504	46683527	16	+	27260156	PATU8988T	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.44190482880557314	[974]	[576,557,901,723]	-6	hSpCas9	negative selection	8796622
46683507	46683530	16	-	27260156	PATU8988T	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.08817412042521522	[947]	[828,844,982,779]	-1	hSpCas9	negative selection	8796623
46681468	46681491	16	-	27260156	T47D	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.33492237976947004	[1808]	[2928,2545,2469,2701]	7	hSpCas9	negative selection	8853624
46681472	46681495	16	+	27260156	T47D	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.28418614833775635	[86]	[95,64,98,73]	-6	hSpCas9	negative selection	8853625
46680799	46680822	16	-	27260156	T47D	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.29539935928323136	[1027]	[1048,1038,919,887]	-6	hSpCas9	negative selection	8853626
46680683	46680706	16	-	27260156	T47D	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.3087748027992532	[345]	[340,332,308,317]	-6	hSpCas9	negative selection	8917872
46683504	46683527	16	+	27260156	T47D	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.20317907654274103	[974]	[874,950,982,1144]	-4	hSpCas9	negative selection	8917873
46683507	46683530	16	-	27260156	T47D	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.30774574569301516	[947]	[917,650,884,1143]	-6	hSpCas9	negative selection	8917874
46681468	46681491	16	-	27260156	SU8686	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.4338570203494132	[1808]	[2164,2126,2527,3020]	7	hSpCas9	negative selection	8974875
46681472	46681495	16	+	27260156	SU8686	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.7156882242248597	[86]	[69,30,60,47]	-8	hSpCas9	negative selection	8974876
46680799	46680822	16	-	27260156	SU8686	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.08637218638215693	[1027]	[1017,881,824,1135]	-1	hSpCas9	negative selection	8974877
46680683	46680706	16	-	27260156	SU8686	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.5378637547948959	[345]	[180,206,307,263]	-7	hSpCas9	negative selection	9039123
46683504	46683527	16	+	27260156	SU8686	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.2788269422259879	[974]	[873,678,706,949]	-5	hSpCas9	negative selection	9039124
46683507	46683530	16	-	27260156	SU8686	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.3336699874638034	[947]	[841,557,735,875]	-5	hSpCas9	negative selection	9039125
46681468	46681491	16	-	27260156	SKES1	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.39695608335800014	[1808]	[2471,2358,2466,2210]	7	hSpCas9	negative selection	9096126
46681472	46681495	16	+	27260156	SKES1	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	0.10331152093940865	[86]	[102,66,96,101]	2	hSpCas9	negative selection	9096127
46680799	46680822	16	-	27260156	SKES1	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.3864292086401583	[1027]	[920,892,632,723]	-7	hSpCas9	negative selection	9096128
46680683	46680706	16	-	27260156	SKES1	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.2181536289458983	[345]	[288,313,317,266]	-5	hSpCas9	negative selection	9160374
46683504	46683527	16	+	27260156	SKES1	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.3248780702759838	[974]	[902,900,612,721]	-6	hSpCas9	negative selection	9160375
46683507	46683530	16	-	27260156	SKES1	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.08248686499148894	[947]	[791,1118,932,748]	-2	hSpCas9	negative selection	9160376
46681468	46681491	16	-	27260156	TOV112D	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.21189989354594707	[1808]	[2307,2591,1804,1831]	4	hSpCas9	negative selection	9217377
46681472	46681495	16	+	27260156	TOV112D	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.7091305037853286	[86]	[88,69,35,25]	-8	hSpCas9	negative selection	9217378
46680799	46680822	16	-	27260156	TOV112D	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.21999371085759156	[1027]	[870,936,694,1038]	-4	hSpCas9	negative selection	9217379
46680683	46680706	16	-	27260156	TOV112D	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.5135707373833711	[345]	[266,281,252,181]	-8	hSpCas9	negative selection	9281625
46683504	46683527	16	+	27260156	TOV112D	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.42578264438826485	[974]	[746,1032,599,606]	-7	hSpCas9	negative selection	9281626
46683507	46683530	16	-	27260156	TOV112D	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.4166970491436667	[947]	[634,1120,602,582]	-7	hSpCas9	negative selection	9281627
46681468	46681491	16	-	27260156	TC71	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.3231773093505723	[1808]	[2577,2535,2197,2393]	7	hSpCas9	negative selection	9338628
46681472	46681495	16	+	27260156	TC71	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.1760238950878028	[86]	[60,73,118,74]	-5	hSpCas9	negative selection	9338629
46680799	46680822	16	-	27260156	TC71	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.28867529393866875	[1027]	[879,902,934,888]	-7	hSpCas9	negative selection	9338630
46680683	46680706	16	-	27260156	TC71	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.6010111837474588	[345]	[209,253,239,276]	-9	hSpCas9	negative selection	9402876
46683504	46683527	16	+	27260156	TC71	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.32136376861730576	[974]	[766,762,922,894]	-7	hSpCas9	negative selection	9402877
46683507	46683530	16	-	27260156	TC71	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.1527397705865886	[947]	[750,869,1001,1041]	-4	hSpCas9	negative selection	9402878
46681468	46681491	16	-	27260156	TC32	viability	TTCTGATGAACTGCACTACTTGG	VPS35	ENSG00000069329	0.48166113559534174	[1808]	[2167,1697,3238,2701]	7	hSpCas9	negative selection	9459879
46681472	46681495	16	+	27260156	TC32	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.16009102317002366	[86]	[63,45,107,88]	-3	hSpCas9	negative selection	9459880
46680799	46680822	16	-	27260156	TC32	viability	TCAAGTCATTTCCTCAGTCCAGG	VPS35	ENSG00000069329	-0.33576244707870295	[1027]	[669,495,998,1022]	-6	hSpCas9	negative selection	9459881
46680683	46680706	16	-	27260156	TC32	viability	AGAAATATCTTACCTGATGAAGG	VPS35	ENSG00000069329	-0.4007041975134903	[345]	[260,168,291,285]	-6	hSpCas9	negative selection	9524127
46683504	46683527	16	+	27260156	TC32	viability	TTACCAGGCATCTCTTCATTTGG	VPS35	ENSG00000069329	-0.24118245150274975	[974]	[823,470,1104,824]	-4	hSpCas9	negative selection	9524128
46683507	46683530	16	-	27260156	TC32	viability	ATTCCAAATGAAGAGATGCCTGG	VPS35	ENSG00000069329	-0.3329449122958079	[947]	[781,524,890,676]	-6	hSpCas9	negative selection	9524129
46661844	46661867	16	-	27869803	HPAFII	viability after 27 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	-0.5638155038976728	[250]	[67,106,NaN]	-4	hSpCas9	negative selection	9557182
46662260	46662283	16	-	27869803	HPAFII	viability after 27 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.13777328361839603	[389]	[259,124,NaN]	-1	hSpCas9	negative selection	9557183
46663081	46663104	16	-	27869803	HPAFII	viability after 27 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-1.456749709020875	[130]	[35,15,NaN]	-7	hSpCas9	negative selection	9557184
46668959	46668982	16	-	27869803	HPAFII	viability after 27 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-3.101216809931732	[45]	[4,0,NaN]	-9	hSpCas9	negative selection	9557185
46671740	46671763	16	+	27869803	HPAFII	viability after 27 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	0.5251797807747851	[92]	[11,118,NaN]	4	hSpCas9	negative selection	9557186
46689039	46689062	16	-	27869803	HPAFII	viability after 27 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.30771035602781605	[404]	[130,373,NaN]	2	hSpCas9	negative selection	9557187
46661844	46661867	16	-	27869803	HPAFII	viability after 15 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	-0.21165991894733588	[250]	[375,143,NaN]	-2	hSpCas9	negative selection	9639631
46662260	46662283	16	-	27869803	HPAFII	viability after 15 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	0.16419784323437225	[389]	[674,341,NaN]	2	hSpCas9	negative selection	9639632
46663081	46663104	16	-	27869803	HPAFII	viability after 15 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-0.4008459519106493	[130]	[134,88,NaN]	-4	hSpCas9	negative selection	9639633
46668959	46668982	16	-	27869803	HPAFII	viability after 15 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-0.23400555059064487	[45]	[62,28,NaN]	-3	hSpCas9	negative selection	9639634
46671740	46671763	16	+	27869803	HPAFII	viability after 15 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	0.4220617903734619	[92]	[136,131,NaN]	5	hSpCas9	negative selection	9639635
46689039	46689062	16	-	27869803	HPAFII	viability after 15 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.33768372071383923	[404]	[792,398,NaN]	4	hSpCas9	negative selection	9639636
46661844	46661867	16	-	27869803	ASPC1	viability after 36 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	0.5392037500591247	[522]	[348,162,284]	5	hSpCas9	negative selection	9722080
46662260	46662283	16	-	27869803	ASPC1	viability after 36 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	0.5490859128446165	[1073]	[363,534,682]	5	hSpCas9	negative selection	9722081
46663081	46663104	16	-	27869803	ASPC1	viability after 36 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	0.711286772655649	[225]	[232,113,66]	7	hSpCas9	negative selection	9722082
46668959	46668982	16	-	27869803	ASPC1	viability after 36 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	0.612145441001821	[123]	[66,31,91]	6	hSpCas9	negative selection	9722083
46671740	46671763	16	+	27869803	ASPC1	viability after 36 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	0.5606009515735209	[180]	[75,90,105]	5	hSpCas9	negative selection	9722084
46689039	46689062	16	-	27869803	ASPC1	viability after 36 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	-0.02106714191575937	[804]	[345,128,342]	0	hSpCas9	negative selection	9722085
46661844	46661867	16	-	27869803	PATU8988S	viability after 35 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	-0.6668417009660194	[545]	[143,132,NaN]	-6	hSpCas9	negative selection	9804529
46662260	46662283	16	-	27869803	PATU8988S	viability after 35 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	0.3473396705924461	[755]	[326,447,NaN]	4	hSpCas9	negative selection	9804530
46663081	46663104	16	-	27869803	PATU8988S	viability after 35 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-0.1737451287563001	[212]	[98,52,NaN]	-2	hSpCas9	negative selection	9804531
46668959	46668982	16	-	27869803	PATU8988S	viability after 35 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-1.0437067294869866	[127]	[27,21,NaN]	-7	hSpCas9	negative selection	9804532
46671740	46671763	16	+	27869803	PATU8988S	viability after 35 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	0.5926731693822183	[154]	[155,31,NaN]	6	hSpCas9	negative selection	9804533
46689039	46689062	16	-	27869803	PATU8988S	viability after 35 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.5791629229223345	[618]	[351,392,NaN]	6	hSpCas9	negative selection	9804534
46661844	46661867	16	-	27869803	PATU8988S	viability after 31 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	-0.4306869176854095	[545]	[179,137,NaN]	-5	hSpCas9	negative selection	9886978
46662260	46662283	16	-	27869803	PATU8988S	viability after 31 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	0.08447528576548513	[755]	[261,392,NaN]	1	hSpCas9	negative selection	9886979
46663081	46663104	16	-	27869803	PATU8988S	viability after 31 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	0.17385473825093234	[212]	[141,36,NaN]	2	hSpCas9	negative selection	9886980
46668959	46668982	16	-	27869803	PATU8988S	viability after 31 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-0.7979488655718985	[127]	[9,53,NaN]	-7	hSpCas9	negative selection	9886981
46671740	46671763	16	+	27869803	PATU8988S	viability after 31 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	0.25753976276248314	[154]	[94,46,NaN]	3	hSpCas9	negative selection	9886982
46689039	46689062	16	-	27869803	PATU8988S	viability after 31 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.5981395689895227	[618]	[326,432,NaN]	7	hSpCas9	negative selection	9886983
46661844	46661867	16	-	27869803	HPAFII	viability after 35 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	-0.5930025161411965	[250]	[95,70,NaN]	-4	hSpCas9	negative selection	9969427
46662260	46662283	16	-	27869803	HPAFII	viability after 35 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.7083120204311872	[389]	[149,87,NaN]	-4	hSpCas9	negative selection	9969428
46663081	46663104	16	-	27869803	HPAFII	viability after 35 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-1.7986129284731895	[130]	[27,8,NaN]	-7	hSpCas9	negative selection	9969429
46668959	46668982	16	-	27869803	HPAFII	viability after 35 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-2.9005854877411896	[45]	[4,0,NaN]	-8	hSpCas9	negative selection	9969430
46671740	46671763	16	+	27869803	HPAFII	viability after 35 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	0.9705767267463956	[92]	[24,167,NaN]	6	hSpCas9	negative selection	9969431
46689039	46689062	16	-	27869803	HPAFII	viability after 35 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.4068505621673397	[404]	[157,399,NaN]	2	hSpCas9	negative selection	9969432
46661844	46661867	16	-	27869803	HPAFII	viability after 31 days	TTTAGCTTCACGGAGGCAAGAGG	VPS35	ENSG00000069329	-0.4752751389656726	[250]	[63,141,NaN]	-3	hSpCas9	negative selection	10051876
46662260	46662283	16	-	27869803	HPAFII	viability after 31 days	CTTCTGGTCTGGCAGAAACACGG	VPS35	ENSG00000069329	-0.6717209201436151	[389]	[190,78,NaN]	-4	hSpCas9	negative selection	10051877
46663081	46663104	16	-	27869803	HPAFII	viability after 31 days	TGCTTTGATCAAAGCAGAGCTGG	VPS35	ENSG00000069329	-1.469411845945401	[130]	[49,0,NaN]	-7	hSpCas9	negative selection	10051878
46668959	46668982	16	-	27869803	HPAFII	viability after 31 days	GGTATTTGCAGCTTACCAGCTGG	VPS35	ENSG00000069329	-1.4663269478286391	[45]	[16,0,NaN]	-7	hSpCas9	negative selection	10051879
46671740	46671763	16	+	27869803	HPAFII	viability after 31 days	GATGAATGAAGCGGCCCACAAGG	VPS35	ENSG00000069329	-0.14507265695829452	[92]	[6,90,NaN]	-1	hSpCas9	negative selection	10051880
46689039	46689062	16	-	27869803	HPAFII	viability after 31 days	GCACTCCAGCGAGTGGAGAAGGG	VPS35	ENSG00000069329	0.6413802568793614	[404]	[198,523,NaN]	5	hSpCas9	negative selection	10051881
46668967	46668990	16	+	28162770	P31FUJ	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-1.8315705046605655	[314]	[103]	-8	hSpCas9	negative selection	10263776
46674614	46674637	16	-	28162770	P31FUJ	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.7092402483573659	[127]	[45]	-8	hSpCas9	negative selection	10263777
46662346	46662369	16	+	28162770	P31FUJ	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	-1.045175201238607	[71]	[40]	-6	hSpCas9	negative selection	10263778
46663096	46663119	16	+	28162770	P31FUJ	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-1.0642026004386338	[241]	[135]	-6	hSpCas9	negative selection	10263779
46663033	46663056	16	-	28162770	P31FUJ	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-0.6945879628847017	[229]	[166]	-5	hSpCas9	negative selection	10263780
46662408	46662431	16	+	28162770	P31FUJ	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-0.8138812706483067	[370]	[247]	-6	hSpCas9	negative selection	10263781
46662360	46662383	16	-	28162770	P31FUJ	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	1.023537548845407	[233]	[558]	9	hSpCas9	negative selection	10263782
46681472	46681495	16	+	28162770	P31FUJ	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.8943229332631681	[415]	[262]	-6	hSpCas9	negative selection	10263783
46680788	46680811	16	+	28162770	P31FUJ	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.4953931801240956	[593]	[983]	5	hSpCas9	negative selection	10263784
46676634	46676657	16	+	28162770	P31FUJ	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	0.1960410943894959	[51]	[69]	2	hSpCas9	negative selection	10263785
46668967	46668990	16	+	28162770	TF1	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	NaN	[NaN]	[50]	1	hSpCas9	negative selection	10433142
46674614	46674637	16	-	28162770	TF1	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	NaN	[NaN]	[32]	1	hSpCas9	negative selection	10433143
46662346	46662369	16	+	28162770	TF1	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	NaN	[NaN]	[47]	1	hSpCas9	negative selection	10433144
46663096	46663119	16	+	28162770	TF1	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	NaN	[NaN]	[16]	1	hSpCas9	negative selection	10433145
46663033	46663056	16	-	28162770	TF1	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	NaN	[NaN]	[25]	1	hSpCas9	negative selection	10433146
46662408	46662431	16	+	28162770	TF1	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	NaN	[NaN]	[129]	1	hSpCas9	negative selection	10433147
46662360	46662383	16	-	28162770	TF1	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	NaN	[NaN]	[495]	1	hSpCas9	negative selection	10433148
46681472	46681495	16	+	28162770	TF1	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	NaN	[NaN]	[134]	1	hSpCas9	negative selection	10433149
46680788	46680811	16	+	28162770	TF1	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	NaN	[NaN]	[779]	1	hSpCas9	negative selection	10433150
46676634	46676657	16	+	28162770	TF1	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10433151
46668967	46668990	16	+	28162770	SKM1	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-2.791628048978487	[93]	[23]	-9	hSpCas9	negative selection	10602508
46674614	46674637	16	-	28162770	SKM1	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.610497592828294	[18]	[10]	-8	hSpCas9	negative selection	10602509
46662346	46662369	16	+	28162770	SKM1	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	-2.3074285251922477	[13]	[4]	-8	hSpCas9	negative selection	10602510
46663096	46663119	16	+	28162770	SKM1	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-2.2241001415933512	[73]	[27]	-8	hSpCas9	negative selection	10602511
46663033	46663056	16	-	28162770	SKM1	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-2.8220016980220057	[67]	[16]	-9	hSpCas9	negative selection	10602512
46662408	46662431	16	+	28162770	SKM1	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-0.8546678869423276	[133]	[130]	-6	hSpCas9	negative selection	10602513
46662360	46662383	16	-	28162770	SKM1	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	0.3108925724753398	[56]	[124]	3	hSpCas9	negative selection	10602514
46681472	46681495	16	+	28162770	SKM1	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-1.6964708159381467	[98]	[53]	-8	hSpCas9	negative selection	10602515
46680788	46680811	16	+	28162770	SKM1	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.3737227728523622	[116]	[267]	3	hSpCas9	negative selection	10602516
46676634	46676657	16	+	28162770	SKM1	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	-0.42607302169086636	[18]	[24]	-4	hSpCas9	negative selection	10602517
46668967	46668990	16	+	28162770	SKM1	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-2.791628048978487	[93]	[23]	-9	hSpCas9	negative selection	10771874
46674614	46674637	16	-	28162770	SKM1	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.610497592828294	[18]	[10]	-8	hSpCas9	negative selection	10771875
46662346	46662369	16	+	28162770	SKM1	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	-2.3074285251922477	[13]	[4]	-8	hSpCas9	negative selection	10771876
46663096	46663119	16	+	28162770	SKM1	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-2.2241001415933512	[73]	[27]	-8	hSpCas9	negative selection	10771877
46663033	46663056	16	-	28162770	SKM1	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-2.8220016980220057	[67]	[16]	-9	hSpCas9	negative selection	10771878
46662408	46662431	16	+	28162770	SKM1	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-0.8546678869423276	[133]	[130]	-6	hSpCas9	negative selection	10771879
46662360	46662383	16	-	28162770	SKM1	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	0.3108925724753398	[56]	[124]	3	hSpCas9	negative selection	10771880
46681472	46681495	16	+	28162770	SKM1	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-1.6964708159381467	[98]	[53]	-8	hSpCas9	negative selection	10771881
46680788	46680811	16	+	28162770	SKM1	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.3737227728523622	[116]	[267]	3	hSpCas9	negative selection	10771882
46676634	46676657	16	+	28162770	SKM1	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	-0.42607302169086636	[18]	[24]	-4	hSpCas9	negative selection	10771883
46668967	46668990	16	+	28162770	PL21	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-1.719029310897635	[294]	[38]	-8	hSpCas9	negative selection	10941240
46674614	46674637	16	-	28162770	PL21	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.8222281985391342	[64]	[7]	-8	hSpCas9	negative selection	10941241
46662346	46662369	16	+	28162770	PL21	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	0.3889012579444878	[92]	[52]	3	hSpCas9	negative selection	10941242
46663096	46663119	16	+	28162770	PL21	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-1.9586876780696618	[258]	[28]	-8	hSpCas9	negative selection	10941243
46663033	46663056	16	-	28162770	PL21	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-2.04516719879513	[274]	[28]	-8	hSpCas9	negative selection	10941244
46662408	46662431	16	+	28162770	PL21	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	0.22736108322434423	[419]	[213]	2	hSpCas9	negative selection	10941245
46662360	46662383	16	-	28162770	PL21	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	0.3020192285085336	[245]	[131]	2	hSpCas9	negative selection	10941246
46681472	46681495	16	+	28162770	PL21	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	0.08995669673889728	[271]	[125]	0	hSpCas9	negative selection	10941247
46680788	46680811	16	+	28162770	PL21	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.03021461304700801	[422]	[187]	0	hSpCas9	negative selection	10941248
46676634	46676657	16	+	28162770	PL21	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	0.6931796257694374	[26]	[18]	6	hSpCas9	negative selection	10941249
46668967	46668990	16	+	28162770	P31FUJ	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-1.8315705046605655	[314]	[103]	-8	hSpCas9	negative selection	11110606
46674614	46674637	16	-	28162770	P31FUJ	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.7092402483573659	[127]	[45]	-8	hSpCas9	negative selection	11110607
46662346	46662369	16	+	28162770	P31FUJ	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	-1.045175201238607	[71]	[40]	-6	hSpCas9	negative selection	11110608
46663096	46663119	16	+	28162770	P31FUJ	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-1.0642026004386338	[241]	[135]	-6	hSpCas9	negative selection	11110609
46663033	46663056	16	-	28162770	P31FUJ	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-0.6945879628847017	[229]	[166]	-5	hSpCas9	negative selection	11110610
46662408	46662431	16	+	28162770	P31FUJ	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-0.8138812706483067	[370]	[247]	-6	hSpCas9	negative selection	11110611
46662360	46662383	16	-	28162770	P31FUJ	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	1.023537548845407	[233]	[558]	9	hSpCas9	negative selection	11110612
46681472	46681495	16	+	28162770	P31FUJ	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.8943229332631681	[415]	[262]	-6	hSpCas9	negative selection	11110613
46680788	46680811	16	+	28162770	P31FUJ	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.4953931801240956	[593]	[983]	5	hSpCas9	negative selection	11110614
46676634	46676657	16	+	28162770	P31FUJ	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	0.1960410943894959	[51]	[69]	2	hSpCas9	negative selection	11110615
46668967	46668990	16	+	28162770	OCIAML5	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	0.23039558932797596	[118]	[251]	2	hSpCas9	negative selection	11279972
46674614	46674637	16	-	28162770	OCIAML5	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-0.6821415694216846	[47]	[53]	-4	hSpCas9	negative selection	11279973
46662346	46662369	16	+	28162770	OCIAML5	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	1.817784827443672	[10]	[69]	9	hSpCas9	negative selection	11279974
46663096	46663119	16	+	28162770	OCIAML5	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-1.1679286650520053	[177]	[142]	-6	hSpCas9	negative selection	11279975
46663033	46663056	16	-	28162770	OCIAML5	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-0.7248313825678891	[140]	[153]	-5	hSpCas9	negative selection	11279976
46662408	46662431	16	+	28162770	OCIAML5	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	0.2917692017096545	[185]	[410]	2	hSpCas9	negative selection	11279977
46662360	46662383	16	-	28162770	OCIAML5	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	1.5558111368419807	[100]	[535]	9	hSpCas9	negative selection	11279978
46681472	46681495	16	+	28162770	OCIAML5	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-0.5625599536690121	[197]	[241]	-4	hSpCas9	negative selection	11279979
46680788	46680811	16	+	28162770	OCIAML5	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	1.2811999599994672	[247]	[1087]	9	hSpCas9	negative selection	11279980
46676634	46676657	16	+	28162770	OCIAML5	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	2.092791874943542	[9]	[76]	9	hSpCas9	negative selection	11279981
46668967	46668990	16	+	28162770	EOL1	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-1.2327991637923081	[570]	[127]	-7	hSpCas9	negative selection	11449338
46674614	46674637	16	-	28162770	EOL1	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-3.660414729150622	[71]	[2]	-9	hSpCas9	negative selection	11449339
46662346	46662369	16	+	28162770	EOL1	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	-1.512857540736764	[129]	[23]	-7	hSpCas9	negative selection	11449340
46663096	46663119	16	+	28162770	EOL1	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-1.209829651192681	[460]	[104]	-7	hSpCas9	negative selection	11449341
46663033	46663056	16	-	28162770	EOL1	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-1.758863217238716	[378]	[58]	-8	hSpCas9	negative selection	11449342
46662408	46662431	16	+	28162770	EOL1	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-0.6604147291506216	[884]	[294]	-5	hSpCas9	negative selection	11449343
46662360	46662383	16	-	28162770	EOL1	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	0.791991578013833	[261]	[238]	7	hSpCas9	negative selection	11449344
46681472	46681495	16	+	28162770	EOL1	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-1.733943764572587	[321]	[50]	-8	hSpCas9	negative selection	11449345
46680788	46680811	16	+	28162770	EOL1	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.7411016304746034	[535]	[471]	6	hSpCas9	negative selection	11449346
46676634	46676657	16	+	28162770	EOL1	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	-2.222293616758737	[61]	[6]	-8	hSpCas9	negative selection	11449347
46668967	46668990	16	+	28162770	MOLM13	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-1.8579858978594466	[365]	[72]	-7	hSpCas9	negative selection	11618704
46674614	46674637	16	-	28162770	MOLM13	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-2.2869981206188896	[80]	[11]	-8	hSpCas9	negative selection	11618705
46662346	46662369	16	+	28162770	MOLM13	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	-0.13828960508627297	[136]	[89]	-1	hSpCas9	negative selection	11618706
46663096	46663119	16	+	28162770	MOLM13	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-1.33136049087597	[354]	[101]	-6	hSpCas9	negative selection	11618707
46663033	46663056	16	-	28162770	MOLM13	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-1.4784419536618358	[342]	[88]	-6	hSpCas9	negative selection	11618708
46662408	46662431	16	+	28162770	MOLM13	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	0.6970901923024975	[603]	[707]	5	hSpCas9	negative selection	11618709
46662360	46662383	16	-	28162770	MOLM13	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	0.19035540601566997	[279]	[230]	1	hSpCas9	negative selection	11618710
46681472	46681495	16	+	28162770	MOLM13	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-1.9297029832748558	[547]	[103]	-7	hSpCas9	negative selection	11618711
46680788	46680811	16	+	28162770	MOLM13	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	-0.808154084851078	[556]	[229]	-4	hSpCas9	negative selection	11618712
46676634	46676657	16	+	28162770	MOLM13	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	-5.14682046257063	[48]	[0]	-9	hSpCas9	negative selection	11618713
46668967	46668990	16	+	28162770	HEL	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-3.478276568961009	[347]	[19]	-9	hSpCas9	negative selection	11788070
46674614	46674637	16	-	28162770	HEL	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-0.513380369916925	[77]	[34]	-3	hSpCas9	negative selection	11788071
46662346	46662369	16	+	28162770	HEL	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	-0.6730370359054101	[116]	[46]	-4	hSpCas9	negative selection	11788072
46663096	46663119	16	+	28162770	HEL	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-3.1606471878543014	[362]	[25]	-9	hSpCas9	negative selection	11788073
46663033	46663056	16	-	28162770	HEL	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-3.8766353270932226	[343]	[14]	-9	hSpCas9	negative selection	11788074
46662408	46662431	16	+	28162770	HEL	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-1.3963139445634176	[673]	[163]	-7	hSpCas9	negative selection	11788075
46662360	46662383	16	-	28162770	HEL	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	0.12093006007073534	[256]	[178]	1	hSpCas9	negative selection	11788076
46681472	46681495	16	+	28162770	HEL	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-3.137774477838606	[425]	[30]	-9	hSpCas9	negative selection	11788077
46680788	46680811	16	+	28162770	HEL	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.9330805838298861	[470]	[575]	7	hSpCas9	negative selection	11788078
46676634	46676657	16	+	28162770	HEL	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	-0.9422236687207994	[62]	[20]	-5	hSpCas9	negative selection	11788079
46668967	46668990	16	+	28162770	MV411	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-2.3566337728860853	[303]	[49]	-8	hSpCas9	negative selection	11957436
46674614	46674637	16	-	28162770	MV411	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.8114561382707928	[74]	[17]	-8	hSpCas9	negative selection	11957437
46662346	46662369	16	+	28162770	MV411	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	0.07548486799348042	[88]	[78]	0	hSpCas9	negative selection	11957438
46663096	46663119	16	+	28162770	MV411	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-2.8298054481496853	[210]	[24]	-9	hSpCas9	negative selection	11957439
46663033	46663056	16	-	28162770	MV411	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-2.1411277371348776	[287]	[54]	-8	hSpCas9	negative selection	11957440
46662408	46662431	16	+	28162770	MV411	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-0.3821939992721092	[409]	[264]	-3	hSpCas9	negative selection	11957441
46662360	46662383	16	-	28162770	MV411	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	1.0804658667298104	[182]	[325]	8	hSpCas9	negative selection	11957442
46681472	46681495	16	+	28162770	MV411	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	0.5208477093807891	[253]	[306]	5	hSpCas9	negative selection	11957443
46680788	46680811	16	+	28162770	MV411	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.8031354569987368	[414]	[609]	7	hSpCas9	negative selection	11957444
46676634	46676657	16	+	28162770	MV411	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	0.19852795030182913	[29]	[28]	1	hSpCas9	negative selection	11957445
46668967	46668990	16	+	28162770	MONOMAC1	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-3.0180667060142343	[211]	[29]	-9	hSpCas9	negative selection	12126802
46674614	46674637	16	-	28162770	MONOMAC1	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.126647519168156	[39]	[20]	-7	hSpCas9	negative selection	12126803
46662346	46662369	16	+	28162770	MONOMAC1	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	-0.9746444257231057	[35]	[20]	-6	hSpCas9	negative selection	12126804
46663096	46663119	16	+	28162770	MONOMAC1	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-2.8541491335365454	[163]	[25]	-9	hSpCas9	negative selection	12126805
46663033	46663056	16	-	28162770	MONOMAC1	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-0.8077624438457917	[112]	[73]	-6	hSpCas9	negative selection	12126806
46662408	46662431	16	+	28162770	MONOMAC1	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	0.24255775646326905	[232]	[315]	2	hSpCas9	negative selection	12126807
46662360	46662383	16	-	28162770	MONOMAC1	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	-0.00859175764644337	[128]	[146]	0	hSpCas9	negative selection	12126808
46681472	46681495	16	+	28162770	MONOMAC1	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	-2.3331735350455824	[210]	[47]	-9	hSpCas9	negative selection	12126809
46680788	46680811	16	+	28162770	MONOMAC1	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.16233647710429122	[250]	[321]	1	hSpCas9	negative selection	12126810
46676634	46676657	16	+	28162770	MONOMAC1	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	0.7623211684431004	[17]	[34]	7	hSpCas9	negative selection	12126811
46668967	46668990	16	+	28162770	OCIAML2	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-2.520382860439261	[58]	[56]	-8	hSpCas9	negative selection	12296168
46674614	46674637	16	-	28162770	OCIAML2	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	-1.8856673245210047	[15]	[23]	-8	hSpCas9	negative selection	12296169
46662346	46662369	16	+	28162770	OCIAML2	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	0.08395902643547615	[7]	[46]	0	hSpCas9	negative selection	12296170
46663096	46663119	16	+	28162770	OCIAML2	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-2.0710223665329233	[46]	[61]	-8	hSpCas9	negative selection	12296171
46663033	46663056	16	-	28162770	OCIAML2	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-0.7206080782505087	[54]	[184]	-5	hSpCas9	negative selection	12296172
46662408	46662431	16	+	28162770	OCIAML2	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-0.47857857835765205	[90]	[361]	-4	hSpCas9	negative selection	12296173
46662360	46662383	16	-	28162770	OCIAML2	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	1.6496644084755503	[22]	[399]	9	hSpCas9	negative selection	12296174
46681472	46681495	16	+	28162770	OCIAML2	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	0.08317174399253435	[38]	[228]	0	hSpCas9	negative selection	12296175
46680788	46680811	16	+	28162770	OCIAML2	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	0.8100756069186883	[70]	[689]	7	hSpCas9	negative selection	12296176
46676634	46676657	16	+	28162770	OCIAML2	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	-1.682133930435873	[10]	[18]	-7	hSpCas9	negative selection	12296177
46668967	46668990	16	+	28162770	OCIAML3	viability	TAAGCTGCAAATACCAAAGGTGG	VPS35	ENSG00000069329	-2.881988403288188	[104]	[42]	-9	hSpCas9	negative selection	12465534
46674614	46674637	16	-	28162770	OCIAML3	viability	AGATGGACCTGGAATCCCAGCGG	VPS35	ENSG00000069329	0.18043265926070595	[18]	[64]	1	hSpCas9	negative selection	12465535
46662346	46662369	16	+	28162770	OCIAML3	viability	AGGGCACACTGAGTCCTCAGAGG	VPS35	ENSG00000069329	0.258435171261979	[17]	[64]	2	hSpCas9	negative selection	12465536
46663096	46663119	16	+	28162770	OCIAML3	viability	TCAAAGCACTGATAGTCTGGTGG	VPS35	ENSG00000069329	-1.1841318461610981	[69]	[92]	-7	hSpCas9	negative selection	12465537
46663033	46663056	16	-	28162770	OCIAML3	viability	TCAAGGAGCACTAGCTGCTGGGG	VPS35	ENSG00000069329	-0.9636532367889925	[72]	[112]	-6	hSpCas9	negative selection	12465538
46662408	46662431	16	+	28162770	OCIAML3	viability	AGTGCCAATGATCAAGGTGATGG	VPS35	ENSG00000069329	-0.31315548843971663	[113]	[276]	-2	hSpCas9	negative selection	12465539
46662360	46662383	16	-	28162770	OCIAML3	viability	AAGAGAATCACGAACCTCTGAGG	VPS35	ENSG00000069329	0.9397295370418197	[42]	[248]	7	hSpCas9	negative selection	12465540
46681472	46681495	16	+	28162770	OCIAML3	viability	GTAGTGCAGTTCATCAGAAATGG	VPS35	ENSG00000069329	0.03552041283043739	[84]	[262]	0	hSpCas9	negative selection	12465541
46680788	46680811	16	+	28162770	OCIAML3	viability	AAAATATCCTTCCTGGACTGAGG	VPS35	ENSG00000069329	-0.19280241422488875	[130]	[345]	-1	hSpCas9	negative selection	12465542
46676634	46676657	16	+	28162770	OCIAML3	viability	TCAGCACAGGCCCGAAGAAAAGG	VPS35	ENSG00000069329	0.022663720124331155	[14]	[45]	0	hSpCas9	negative selection	12465543