Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 124997
• Symbol: WDR81
• Description: WD repeat domain 81

DataSource: http://genomecrispr.dkfz.de/#!/results/WDR81

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
1730896	1730919	CHR_HSCHR17_1_CTG2	-	26472758	Jiyoye	viability	GGACAGGCTCCCCATACAGGCGG	WDR81	ENSG00000276021	0.4071753815058735	[68]	[68]	3	hSpCas9	negative selection	181530
1736080	1736103	CHR_HSCHR17_1_CTG2	-	26472758	Jiyoye	viability	GCCAGGGCACGGACAAGCCCAGG	WDR81	ENSG00000276021	1.5175993711995237	[43]	[94]	8	hSpCas9	negative selection	181531
1732785	1732808	CHR_HSCHR17_1_CTG2	+	26472758	Jiyoye	viability	GAAGGTGTTCACCCTGGAGATGG	WDR81	ENSG00000276021	0.004628826410226383	[114]	[86]	0	hSpCas9	negative selection	181532
1730407	1730430	CHR_HSCHR17_1_CTG2	-	26472758	Jiyoye	viability	CGAGCTTGGCAGACAGCCAGCGG	WDR81	ENSG00000276021	1.73367620618306	[62]	[157]	8	hSpCas9	negative selection	181533
1730774	1730797	CHR_HSCHR17_1_CTG2	+	26472758	Jiyoye	viability	CAGCAGTTCACAGTGAGCAGTGG	WDR81	ENSG00000276021	-1.0872748263098404	[416]	[147]	-6	hSpCas9	negative selection	181534
1730804	1730827	CHR_HSCHR17_1_CTG2	-	26472758	Jiyoye	viability	ATGTTGCCGGCGCTCAGCGGTGG	WDR81	ENSG00000276021	0.022511531270548613	[46]	[35]	0	hSpCas9	negative selection	181535
1731232	1731255	CHR_HSCHR17_1_CTG2	-	26472758	Jiyoye	viability	GAGGTGAGGAAGCTGAGCACGGG	WDR81	ENSG00000276021	-2.6655809609294407	[243]	[28]	-9	hSpCas9	negative selection	181536
1732761	1732784	CHR_HSCHR17_1_CTG2	-	26472758	Jiyoye	viability	GCAGCTCGTCCAGCAGGGCGGGG	WDR81	ENSG00000276021	2.930737337562886	[3]	[22]	9	hSpCas9	negative selection	181537
1735590	1735613	CHR_HSCHR17_1_CTG2	-	26472758	Jiyoye	viability	CCAGCGGCTCCACTGTGCGAAGG	WDR81	ENSG00000276021	-1.8407521319377123	[37]	[7]	-8	hSpCas9	negative selection	181538
1735670	1735693	CHR_HSCHR17_1_CTG2	-	26472758	Jiyoye	viability	GGTAGAGTCAGAGCTGGCCATGG	WDR81	ENSG00000276021	-2.4932889449432123	[111]	[14]	-9	hSpCas9	negative selection	181539
1730896	1730919	CHR_HSCHR17_1_CTG2	-	26472758	KBM7	viability	GGACAGGCTCCCCATACAGGCGG	WDR81	ENSG00000276021	-0.48020366719075813	[223,221]	[84,66]	-4	hSpCas9	negative selection	372648
1736080	1736103	CHR_HSCHR17_1_CTG2	-	26472758	KBM7	viability	GCCAGGGCACGGACAAGCCCAGG	WDR81	ENSG00000276021	0.5223988243120716	[358,232]	[129,255]	5	hSpCas9	negative selection	372649
1732785	1732808	CHR_HSCHR17_1_CTG2	+	26472758	KBM7	viability	GAAGGTGTTCACCCTGGAGATGG	WDR81	ENSG00000276021	-0.4870854077417954	[756,627]	[226,234]	-4	hSpCas9	negative selection	372650
1730407	1730430	CHR_HSCHR17_1_CTG2	-	26472758	KBM7	viability	CGAGCTTGGCAGACAGCCAGCGG	WDR81	ENSG00000276021	0.3541736084409901	[460,364]	[312,186]	4	hSpCas9	negative selection	372651
1730774	1730797	CHR_HSCHR17_1_CTG2	+	26472758	KBM7	viability	CAGCAGTTCACAGTGAGCAGTGG	WDR81	ENSG00000276021	0.9281043128756866	[806,499]	[696,462]	8	hSpCas9	negative selection	372652
1730804	1730827	CHR_HSCHR17_1_CTG2	-	26472758	KBM7	viability	ATGTTGCCGGCGCTCAGCGGTGG	WDR81	ENSG00000276021	1.2168750136390951	[148,97]	[202,69]	9	hSpCas9	negative selection	372653
1731232	1731255	CHR_HSCHR17_1_CTG2	-	26472758	KBM7	viability	GAGGTGAGGAAGCTGAGCACGGG	WDR81	ENSG00000276021	-1.8581450814766083	[557,559]	[65,78]	-8	hSpCas9	negative selection	372654
1732761	1732784	CHR_HSCHR17_1_CTG2	-	26472758	KBM7	viability	GCAGCTCGTCCAGCAGGGCGGGG	WDR81	ENSG00000276021	-0.7845417170765634	[74,16]	[5,16]	-6	hSpCas9	negative selection	372655
1735590	1735613	CHR_HSCHR17_1_CTG2	-	26472758	KBM7	viability	CCAGCGGCTCCACTGTGCGAAGG	WDR81	ENSG00000276021	-0.040162679007666346	[156,233]	[107,76]	0	hSpCas9	negative selection	372656
1735670	1735693	CHR_HSCHR17_1_CTG2	-	26472758	KBM7	viability	GGTAGAGTCAGAGCTGGCCATGG	WDR81	ENSG00000276021	-0.08951986003946466	[124,89]	[47,45]	-1	hSpCas9	negative selection	372657
1730896	1730919	CHR_HSCHR17_1_CTG2	-	26472758	Raji	viability	GGACAGGCTCCCCATACAGGCGG	WDR81	ENSG00000276021	0.21121934635813955	[133]	[35]	2	hSpCas9	negative selection	563766
1736080	1736103	CHR_HSCHR17_1_CTG2	-	26472758	Raji	viability	GCCAGGGCACGGACAAGCCCAGG	WDR81	ENSG00000276021	-0.08816727374420741	[141]	[30]	0	hSpCas9	negative selection	563767
1732785	1732808	CHR_HSCHR17_1_CTG2	+	26472758	Raji	viability	GAAGGTGTTCACCCTGGAGATGG	WDR81	ENSG00000276021	-0.7255064787911422	[341]	[47]	-5	hSpCas9	negative selection	563768
1730407	1730430	CHR_HSCHR17_1_CTG2	-	26472758	Raji	viability	CGAGCTTGGCAGACAGCCAGCGG	WDR81	ENSG00000276021	1.3558818480495127	[132]	[78]	9	hSpCas9	negative selection	563769
1730774	1730797	CHR_HSCHR17_1_CTG2	+	26472758	Raji	viability	CAGCAGTTCACAGTGAGCAGTGG	WDR81	ENSG00000276021	-0.7743535830065807	[397]	[53]	-5	hSpCas9	negative selection	563770
1730804	1730827	CHR_HSCHR17_1_CTG2	-	26472758	Raji	viability	ATGTTGCCGGCGCTCAGCGGTGG	WDR81	ENSG00000276021	0.5224210346524432	[89]	[29]	5	hSpCas9	negative selection	563771
1731232	1731255	CHR_HSCHR17_1_CTG2	-	26472758	Raji	viability	GAGGTGAGGAAGCTGAGCACGGG	WDR81	ENSG00000276021	-2.8297896271709613	[336]	[10]	-9	hSpCas9	negative selection	563772
1732761	1732784	CHR_HSCHR17_1_CTG2	-	26472758	Raji	viability	GCAGCTCGTCCAGCAGGGCGGGG	WDR81	ENSG00000276021	1.048489846320031	[24]	[11]	8	hSpCas9	negative selection	563773
1735590	1735613	CHR_HSCHR17_1_CTG2	-	26472758	Raji	viability	CCAGCGGCTCCACTGTGCGAAGG	WDR81	ENSG00000276021	0.24344508494962813	[90]	[24]	2	hSpCas9	negative selection	563774
1735670	1735693	CHR_HSCHR17_1_CTG2	-	26472758	Raji	viability	GGTAGAGTCAGAGCTGGCCATGG	WDR81	ENSG00000276021	0.5964216160962201	[56]	[19]	5	hSpCas9	negative selection	563775
1730896	1730919	CHR_HSCHR17_1_CTG2	-	26472758	K562	viability	GGACAGGCTCCCCATACAGGCGG	WDR81	ENSG00000276021	-1.1952044098906698	[216]	[79]	-6	hSpCas9	negative selection	754884
1736080	1736103	CHR_HSCHR17_1_CTG2	-	26472758	K562	viability	GCCAGGGCACGGACAAGCCCAGG	WDR81	ENSG00000276021	-0.17273882348676628	[226]	[169]	-1	hSpCas9	negative selection	754885
1732785	1732808	CHR_HSCHR17_1_CTG2	+	26472758	K562	viability	GAAGGTGTTCACCCTGGAGATGG	WDR81	ENSG00000276021	-0.7501199596633873	[790]	[396]	-4	hSpCas9	negative selection	754886
1730407	1730430	CHR_HSCHR17_1_CTG2	-	26472758	K562	viability	CGAGCTTGGCAGACAGCCAGCGG	WDR81	ENSG00000276021	-0.1865332609757706	[394]	[292]	-1	hSpCas9	negative selection	754887
1730774	1730797	CHR_HSCHR17_1_CTG2	+	26472758	K562	viability	CAGCAGTTCACAGTGAGCAGTGG	WDR81	ENSG00000276021	1.0206898587671849	[629]	[1078]	8	hSpCas9	negative selection	754888
1730804	1730827	CHR_HSCHR17_1_CTG2	-	26472758	K562	viability	ATGTTGCCGGCGCTCAGCGGTGG	WDR81	ENSG00000276021	-0.29990178855736316	[69]	[47]	-2	hSpCas9	negative selection	754889
1731232	1731255	CHR_HSCHR17_1_CTG2	-	26472758	K562	viability	GAGGTGAGGAAGCTGAGCACGGG	WDR81	ENSG00000276021	-2.5406833875440293	[385]	[55]	-8	hSpCas9	negative selection	754890
1732761	1732784	CHR_HSCHR17_1_CTG2	-	26472758	K562	viability	GCAGCTCGTCCAGCAGGGCGGGG	WDR81	ENSG00000276021	-0.6223147414700896	[30]	[16]	-4	hSpCas9	negative selection	754891
1735590	1735613	CHR_HSCHR17_1_CTG2	-	26472758	K562	viability	CCAGCGGCTCCACTGTGCGAAGG	WDR81	ENSG00000276021	0.24441872766644712	[96]	[96]	1	hSpCas9	negative selection	754892
1735670	1735693	CHR_HSCHR17_1_CTG2	-	26472758	K562	viability	GGTAGAGTCAGAGCTGGCCATGG	WDR81	ENSG00000276021	-0.0876573225969981	[106]	[84]	0	hSpCas9	negative selection	754893
1716606	1716629	17	-	26627737	DLD1	viability	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	-0.8495181790033288	[1422]	[266,349,143]	-7	hSpCas9	negative selection	796261
1725115	1725138	17	-	26627737	DLD1	viability	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	0.3445477356942701	[745]	[349,397,164]	3	hSpCas9	negative selection	796270
1716606	1716629	17	-	26627737	GBM cells	viability after 5 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.09285575744653385	[555]	[286,348]	1	hSpCas9	negative selection	878576
1725115	1725138	17	-	26627737	GBM cells	viability after 5 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-0.39707095274939486	[495]	[173,229]	-6	hSpCas9	negative selection	878585
1716606	1716629	17	-	26627737	GBM cells	viability after 13 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.16193717371525707	[555]	[390,293]	2	hSpCas9	negative selection	960891
1725115	1725138	17	-	26627737	GBM cells	viability after 13 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-0.38137620463854605	[495]	[242,176]	-4	hSpCas9	negative selection	960900
1716606	1716629	17	-	26627737	GBM cells	viability after 21 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.6246181395485584	[555]	[483,448]	6	hSpCas9	negative selection	1043206
1725115	1725138	17	-	26627737	GBM cells	viability after 21 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-0.6794526796668343	[495]	[173,162]	-5	hSpCas9	negative selection	1043215
1716606	1716629	17	-	26627737	RPE1	viability after 9 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	-0.8936323184351935	[2915]	[369,647]	-6	hSpCas9	negative selection	1125521
1725115	1725138	17	-	26627737	RPE1	viability after 9 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-0.2025600932509969	[1732]	[398,564]	-1	hSpCas9	negative selection	1125530
1716606	1716629	17	-	26627737	RPE1	viability after 12 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	-1.1429175756473189	[2915]	[278,434]	-7	hSpCas9	negative selection	1207836
1725115	1725138	17	-	26627737	RPE1	viability after 12 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-0.3057270172487798	[1732]	[450,297]	-2	hSpCas9	negative selection	1207845
1716606	1716629	17	-	26627737	RPE1	viability after 15 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	-1.3134586822227603	[2915]	[337,325]	-7	hSpCas9	negative selection	1290151
1725115	1725138	17	-	26627737	RPE1	viability after 15 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-1.0308517374582549	[1732]	[243,235]	-6	hSpCas9	negative selection	1290160
1716606	1716629	17	-	26627737	RPE1	viability after 18 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	-1.2368324133078827	[2915]	[228,445]	-6	hSpCas9	negative selection	1372466
1725115	1725138	17	-	26627737	RPE1	viability after 18 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-1.0192675133283033	[1732]	[193,269]	-6	hSpCas9	negative selection	1372475
1716606	1716629	17	-	26627737	HeLa	viability after 8 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.6177014632084521	[962]	[575,810,534]	5	hSpCas9	negative selection	1454781
1725115	1725138	17	-	26627737	HeLa	viability after 8 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-0.6489628211054518	[649]	[208,210,130]	-6	hSpCas9	negative selection	1454790
1716606	1716629	17	-	26627737	HeLa	viability after 12 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.4006691116434662	[962]	[285,592,682]	3	hSpCas9	negative selection	1537096
1725115	1725138	17	-	26627737	HeLa	viability after 12 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	0.06870709598452218	[649]	[198,288,353]	0	hSpCas9	negative selection	1537105
1716606	1716629	17	-	26627737	HeLa	viability after 15 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.5438003210789133	[962]	[324,648,757]	4	hSpCas9	negative selection	1619411
1725115	1725138	17	-	26627737	HeLa	viability after 15 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	0.6674761403499372	[649]	[354,494,410]	5	hSpCas9	negative selection	1619420
1716606	1716629	17	-	26627737	HeLa	viability after 18 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.5430534772742626	[962]	[216,537,757]	4	hSpCas9	negative selection	1701726
1725115	1725138	17	-	26627737	HeLa	viability after 18 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	0.6644878038358399	[649]	[237,407,410]	5	hSpCas9	negative selection	1701735
1716606	1716629	17	-	26627737	HCT116	viability after 6 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.47819377944453434	[1503]	[572,194]	2	hSpCas9	negative selection	1784041
1725115	1725138	17	-	26627737	HCT116	viability after 6 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	0.9426662745999826	[1080]	[490,235]	5	hSpCas9	negative selection	1784050
1716606	1716629	17	-	26627737	HCT116	viability after 8 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.26120852850475473	[693]	[338,425,605]	3	hSpCas9	negative selection	1866356
1725115	1725138	17	-	26627737	HCT116	viability after 8 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-0.5843737556846964	[668]	[208,288,238]	-6	hSpCas9	negative selection	1866365
1716606	1716629	17	-	26627737	HCT116	viability after 9 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.726888153352871	[1503]	[953,435]	5	hSpCas9	negative selection	1948671
1725115	1725138	17	-	26627737	HCT116	viability after 9 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	0.2517807569985596	[1080]	[360,329]	2	hSpCas9	negative selection	1948680
1716606	1716629	17	-	26627737	HCT116	viability after 12 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.07786531872289348	[693]	[313,423,423]	0	hSpCas9	negative selection	2030986
1725115	1725138	17	-	26627737	HCT116	viability after 12 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-0.9549703244068566	[668]	[121,168,257]	-8	hSpCas9	negative selection	2030995
1716606	1716629	17	-	26627737	HCT116	viability after 15 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.36614724508352303	[693]	[635,571,349]	3	hSpCas9	negative selection	2113301
1725115	1725138	17	-	26627737	HCT116	viability after 15 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-0.579632932807939	[668]	[245,274,248]	-5	hSpCas9	negative selection	2113310
1716606	1716629	17	-	26627737	HCT116	viability after 18 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	-0.009910906813247244	[693]	[436,261,303]	0	hSpCas9	negative selection	2195616
1725115	1725138	17	-	26627737	HCT116	viability after 18 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-0.9891338548566754	[668]	[125,107,262]	-7	hSpCas9	negative selection	2195625
1724649	1724672	17	-	25494202	A375	resistance to PLX-4720 (puromycin)	ACAAGCGCACGTGGCTCCAGAGG	WDR81	ENSG00000167716	-0.06954549539492727	[40,59]	[11,7]	0	dCas9-VP64	positive selection	2404117
1724657	1724680	CHR_HSCHR17_1_CTG2	-	25494202	A375	resistance to PLX-4720 (puromycin)	ACAAGCGCACGTGGCTCCAGAGG	WDR81	ENSG00000276021	-0.06954549539492727	[40,59]	[11,7]	0	dCas9-VP64	positive selection	2404118
1724682	1724705	CHR_HSCHR17_1_CTG2	-	25494202	A375	resistance to PLX-4720 (puromycin)	GTCACGTGATCGCCCCAGCACGG	WDR81	ENSG00000276021	1.1845290767288084	[112,21]	[58,4]	4	dCas9-VP64	positive selection	2404119
1724674	1724697	17	-	25494202	A375	resistance to PLX-4720 (puromycin)	GTCACGTGATCGCCCCAGCACGG	WDR81	ENSG00000167716	1.1845290767288084	[112,21]	[58,4]	4	dCas9-VP64	positive selection	2404120
1724715	1724738	CHR_HSCHR17_1_CTG2	+	25494202	A375	resistance to PLX-4720 (puromycin)	TGACCCGTCACGGTGGAGCCCGG	WDR81	ENSG00000276021	1.019641592305189	[30,103]	[3,57]	4	dCas9-VP64	positive selection	2404121
1724707	1724730	17	+	25494202	A375	resistance to PLX-4720 (puromycin)	TGACCCGTCACGGTGGAGCCCGG	WDR81	ENSG00000167716	1.019641592305189	[30,103]	[3,57]	4	dCas9-VP64	positive selection	2404122
1724441	1724464	CHR_HSCHR17_1_CTG2	+	25494202	A375	resistance to PLX-4720 (puromycin)	CATCTCTGGGAACAGCCTCCGGG	WDR81	ENSG00000276021	-0.0623115158077443	[235,742]	[23,189]	0	dCas9-VP64	positive selection	2404123
1724433	1724456	17	+	25494202	A375	resistance to PLX-4720 (puromycin)	CATCTCTGGGAACAGCCTCCGGG	WDR81	ENSG00000167716	-0.0623115158077443	[235,742]	[23,189]	0	dCas9-VP64	positive selection	2404124
1724418	1724441	CHR_HSCHR17_1_CTG2	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCCGCACTTAACTAAGAGGCTGG	WDR81	ENSG00000276021	-0.5824830953298126	[14,35]	[4,1]	-3	dCas9-VP64	positive selection	2404125
1724410	1724433	17	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCCGCACTTAACTAAGAGGCTGG	WDR81	ENSG00000167716	-0.5824830953298126	[14,35]	[4,1]	-3	dCas9-VP64	positive selection	2404126
1724365	1724388	CHR_HSCHR17_1_CTG2	-	25494202	A375	resistance to PLX-4720 (puromycin)	TGTTGTGTCTATTTTTGAGACGG	WDR81	ENSG00000276021	0.4997421337367496	[524,509]	[171,147]	2	dCas9-VP64	positive selection	2404127
1724357	1724380	17	-	25494202	A375	resistance to PLX-4720 (puromycin)	TGTTGTGTCTATTTTTGAGACGG	WDR81	ENSG00000167716	0.4997421337367496	[524,509]	[171,147]	2	dCas9-VP64	positive selection	2404128
1734745	1734768	CHR_HSCHR17_1_CTG2	+	25494202	A375	resistance to PLX-4720 (puromycin)	CGCACCACTGCACTCCAGCCCGG	WDR81	ENSG00000276021	3.0347564003538725	[8,6]	[27,0]	8	dCas9-VP64	positive selection	2470797
1724649	1724672	17	-	25494202	A375	resistance to PLX-4720 (zeocin)	ACAAGCGCACGTGGCTCCAGAGG	WDR81	ENSG00000167716	1.203505732579671	[200,193]	[269,35]	7	dCas9-VP64	positive selection	2499372
1724657	1724680	CHR_HSCHR17_1_CTG2	-	25494202	A375	resistance to PLX-4720 (zeocin)	ACAAGCGCACGTGGCTCCAGAGG	WDR81	ENSG00000276021	1.203505732579671	[200,193]	[269,35]	7	dCas9-VP64	positive selection	2499373
1724682	1724705	CHR_HSCHR17_1_CTG2	-	25494202	A375	resistance to PLX-4720 (zeocin)	GTCACGTGATCGCCCCAGCACGG	WDR81	ENSG00000276021	1.1159609425326218	[65,204]	[157,35]	7	dCas9-VP64	positive selection	2499374
1724674	1724697	17	-	25494202	A375	resistance to PLX-4720 (zeocin)	GTCACGTGATCGCCCCAGCACGG	WDR81	ENSG00000167716	1.1159609425326218	[65,204]	[157,35]	7	dCas9-VP64	positive selection	2499375
1724715	1724738	CHR_HSCHR17_1_CTG2	+	25494202	A375	resistance to PLX-4720 (zeocin)	TGACCCGTCACGGTGGAGCCCGG	WDR81	ENSG00000276021	-0.34376260727468627	[204,106]	[52,27]	-3	dCas9-VP64	positive selection	2499376
1724707	1724730	17	+	25494202	A375	resistance to PLX-4720 (zeocin)	TGACCCGTCACGGTGGAGCCCGG	WDR81	ENSG00000167716	-0.34376260727468627	[204,106]	[52,27]	-3	dCas9-VP64	positive selection	2499377
1724441	1724464	CHR_HSCHR17_1_CTG2	+	25494202	A375	resistance to PLX-4720 (zeocin)	CATCTCTGGGAACAGCCTCCGGG	WDR81	ENSG00000276021	0.30409445450160183	[167,109]	[49,61]	2	dCas9-VP64	positive selection	2499378
1724433	1724456	17	+	25494202	A375	resistance to PLX-4720 (zeocin)	CATCTCTGGGAACAGCCTCCGGG	WDR81	ENSG00000167716	0.30409445450160183	[167,109]	[49,61]	2	dCas9-VP64	positive selection	2499379
1724418	1724441	CHR_HSCHR17_1_CTG2	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCCGCACTTAACTAAGAGGCTGG	WDR81	ENSG00000276021	-0.13775795773290667	[85,45]	[26,11]	-1	dCas9-VP64	positive selection	2499380
1724410	1724433	17	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCCGCACTTAACTAAGAGGCTGG	WDR81	ENSG00000167716	-0.13775795773290667	[85,45]	[26,11]	-1	dCas9-VP64	positive selection	2499381
1724365	1724388	CHR_HSCHR17_1_CTG2	-	25494202	A375	resistance to PLX-4720 (zeocin)	TGTTGTGTCTATTTTTGAGACGG	WDR81	ENSG00000276021	-1.0482411419674207	[265,265]	[48,34]	-8	dCas9-VP64	positive selection	2499382
1724357	1724380	17	-	25494202	A375	resistance to PLX-4720 (zeocin)	TGTTGTGTCTATTTTTGAGACGG	WDR81	ENSG00000167716	-1.0482411419674207	[265,265]	[48,34]	-8	dCas9-VP64	positive selection	2499383
1734745	1734768	CHR_HSCHR17_1_CTG2	+	25494202	A375	resistance to PLX-4720 (zeocin)	CGCACCACTGCACTCCAGCCCGG	WDR81	ENSG00000276021	0.038175304513698105	[60,77]	[26,18]	0	dCas9-VP64	positive selection	2566052
1716560	1716583	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	TCTGCGTTTGCAATGCATGCTGG	WDR81	ENSG00000276021	0.21183898025674452	[372,400]	[127,284]	1	hSpCas9	positive selection	2963971
1716560	1716583	17	+	27013184	SW480	treatment with recombinant TRAIL	TCTGCGTTTGCAATGCATGCTGG	WDR81	ENSG00000167716	0.21183898025674452	[372,400]	[127,284]	1	hSpCas9	positive selection	2963972
1716620	1716643	17	+	27013184	SW480	treatment with recombinant TRAIL	ACCCAGCGCGCTCTGTGAGTTGG	WDR81	ENSG00000167716	-0.8236182427356564	[407,566]	[105,132]	-4	hSpCas9	positive selection	2963973
1716620	1716643	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	ACCCAGCGCGCTCTGTGAGTTGG	WDR81	ENSG00000276021	-0.8236182427356564	[407,566]	[105,132]	-4	hSpCas9	positive selection	2963974
1730449	1730472	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	GGAGCAGGTTCCGGGCCACGTGG	WDR81	ENSG00000276021	0.2549432739061739	[71,79]	[33,45]	1	hSpCas9	positive selection	2963976
1730458	1730481	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	TCAGCAGGCGGAGCAGGTTCCGG	WDR81	ENSG00000276021	0.755976931307292	[150,97]	[77,112]	3	hSpCas9	positive selection	2963978
1730749	1730772	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	GAGTGGGTCCTGCCACGGAAGGG	WDR81	ENSG00000276021	0.011553755726622764	[148,277]	[51,144]	0	hSpCas9	positive selection	2963980
1730750	1730773	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	CGAGTGGGTCCTGCCACGGAAGG	WDR81	ENSG00000276021	-2.719211660814584	[169,218]	[5,21]	-8	hSpCas9	positive selection	2963982
1730765	1730788	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	ACTGTGAACTGCTGCCGAGTGGG	WDR81	ENSG00000276021	2.0435668736469217	[119,127]	[233,199]	8	hSpCas9	positive selection	2963983
1730766	1730789	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	CACTGTGAACTGCTGCCGAGTGG	WDR81	ENSG00000276021	-0.08449540462842964	[410,614]	[214,190]	0	hSpCas9	positive selection	2963985
1730807	1730830	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	TAGATGTTGCCGGCGCTCAGCGG	WDR81	ENSG00000276021	-2.7432454429129747	[243,594]	[11,45]	-8	hSpCas9	positive selection	2963988
1730845	1730868	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	GCCCTGACACGATGTCGCCCAGG	WDR81	ENSG00000276021	-0.11451263606796602	[506,611]	[254,172]	0	hSpCas9	positive selection	2963989
1730884	1730907	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	CATACAGGCGGGCGATGTGGAGG	WDR81	ENSG00000276021	-0.5413567639690819	[188,226]	[9,133]	-2	hSpCas9	positive selection	2963991
1730887	1730910	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	CCCCATACAGGCGGGCGATGTGG	WDR81	ENSG00000276021	-0.23845061966249204	[55,50]	[17,21]	-1	hSpCas9	positive selection	2963994
1730899	1730922	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	TGAGGACAGGCTCCCCATACAGG	WDR81	ENSG00000276021	-0.1263248174647762	[426,658]	[151,293]	0	hSpCas9	positive selection	2963996
1730926	1730949	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	AGCTGATGTAGGGCAGGTACTGG	WDR81	ENSG00000276021	0.7267941049950285	[258,224]	[137,224]	3	hSpCas9	positive selection	2963997
1730932	1730955	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	CCAGGTAGCTGATGTAGGGCAGG	WDR81	ENSG00000276021	0.6081809218948981	[219,194]	[142,128]	3	hSpCas9	positive selection	2963999
1730936	1730959	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	CTGACCAGGTAGCTGATGTAGGG	WDR81	ENSG00000276021	-3.4364857489868115	[183,148]	[9,1]	-9	hSpCas9	positive selection	2964002
1730937	1730960	CHR_HSCHR17_1_CTG2	-	27013184	SW480	treatment with recombinant TRAIL	ACTGACCAGGTAGCTGATGTAGG	WDR81	ENSG00000276021	-0.05709530759178305	[376,212]	[138,105]	0	hSpCas9	positive selection	2964003
1730489	1730512	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	TATGTTGGTAAGGAGGCCTGCGG	WDR81	ENSG00000276021	1.393877768078388	[194,285]	[100,505]	6	hSpCas9	positive selection	2964005
1730751	1730774	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	CTTCCGTGGCAGGACCCACTCGG	WDR81	ENSG00000276021	1.6516101751812742	[294,702]	[762,493]	7	hSpCas9	positive selection	2964008
1730774	1730797	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	CAGCAGTTCACAGTGAGCAGTGG	WDR81	ENSG00000276021	0.6228673683737554	[210,230]	[52,278]	3	hSpCas9	positive selection	2964010
1730827	1730850	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	CTACCAGAAGAGGCCGGTCCTGG	WDR81	ENSG00000276021	0.2468835838369867	[308,177]	[66,213]	1	hSpCas9	positive selection	2964011
1730828	1730851	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	TACCAGAAGAGGCCGGTCCTGGG	WDR81	ENSG00000276021	-0.6776267137676732	[264,444]	[79,112]	-3	hSpCas9	positive selection	2964014
1730843	1730866	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	GTCCTGGGCGACATCGTGTCAGG	WDR81	ENSG00000276021	1.323576542884227	[131,389]	[193,376]	6	hSpCas9	positive selection	2964015
1730844	1730867	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	TCCTGGGCGACATCGTGTCAGGG	WDR81	ENSG00000276021	-0.29721509156852766	[170,91]	[46,47]	-1	hSpCas9	positive selection	2964017
1730885	1730908	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	CTCCACATCGCCCGCCTGTATGG	WDR81	ENSG00000276021	0.13692986657553075	[310,509]	[216,152]	0	hSpCas9	positive selection	2964019
1730886	1730909	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	TCCACATCGCCCGCCTGTATGGG	WDR81	ENSG00000276021	0.6368128254955268	[443,888]	[246,699]	3	hSpCas9	positive selection	2964021
1730887	1730910	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	CCACATCGCCCGCCTGTATGGGG	WDR81	ENSG00000276021	1.0974045799914727	[238,167]	[170,218]	5	hSpCas9	positive selection	2964024
1730932	1730955	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	CCTGCCCTACATCAGCTACCTGG	WDR81	ENSG00000276021	2.38222585527649	[635,485]	[695,2103]	8	hSpCas9	positive selection	2964025
1730943	1730966	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	TCAGCTACCTGGTCAGTCGCTGG	WDR81	ENSG00000276021	0.6688225880384527	[79,149]	[51,111]	3	hSpCas9	positive selection	2964028
1728529	1728552	CHR_HSCHR17_1_CTG2	+	27013184	SW480	treatment with recombinant TRAIL	TCCATGGAGACGGTTGTGGCCGG	WDR81	ENSG00000276021	-0.6580034992116424	[160,73]	[26,41]	-3	hSpCas9	positive selection	2964030
1716599	1716622		-	24336571	A375	resistance to PLX after 7 days	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.3647236308341287	[7,11]	[6,7]	-8	hSpCas9	positive selection	3155578
1716622	1716645		-	24336571	A375	resistance to PLX after 7 days	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	0.24523062189610823	[6,4]	[6,5]	7	hSpCas9	positive selection	3155579
1716599	1716622		-	24336571	A375	resistance to PLX after 14 days	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.14289204304910663	[10,9]	[3,3]	-1	hSpCas9	positive selection	3213371
1716622	1716645		-	24336571	A375	resistance to PLX after 14 days	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	0.38007966984268804	[4,3]	[2,1]	3	hSpCas9	positive selection	3213372
1716599	1716622		-	24336571	A375	viability after 7 days	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.6072586246837215	[6]	[7,11]	8	hSpCas9	negative selection	3271164
1716622	1716645		-	24336571	A375	viability after 7 days	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.3429072305527404	[7]	[6,4]	-5	hSpCas9	negative selection	3271165
1716599	1716622		-	24336571	A375	viability after 14 days	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.6662423102746717	[6]	[10,9]	8	hSpCas9	negative selection	3328957
1716622	1716645		-	24336571	A375	viability after 14 days	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.57201407069222	[7]	[4,3]	-6	hSpCas9	negative selection	3328958
1716599	1716622	17	-	27383988	293T	resistance to West Nile virus (flavivirus)	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.46291034509572904	[110,110]	[0,0]	2	hSpCas9	positive selection	3401380
1716622	1716645	17	-	27383988	293T	resistance to West Nile virus (flavivirus)	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	0.48914188666890873	[108,108]	[0,0]	2	hSpCas9	positive selection	3401381
1725150	1725173	17	-	26780180	A375	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	1.57099130255678	[]	[]	8	hSpCas9	negative selection	4012539
1716599	1716622	17	-	26780180	A375	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.914896266616835	[]	[]	4	hSpCas9	negative selection	4012540
1716622	1716645	17	-	26780180	A375	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	2.13871454824699	[]	[]	9	hSpCas9	negative selection	4012541
1725150	1725173	17	-	26780180	HT29	viability (GeCKOv2 library)	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.705045679867014	[]	[]	2	hSpCas9	negative selection	4120505
1716599	1716622	17	-	26780180	HT29	viability (GeCKOv2 library)	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.850949851228932	[]	[]	3	hSpCas9	negative selection	4120506
1716622	1716645	17	-	26780180	HT29	viability (GeCKOv2 library)	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	2.10901858764703	[]	[]	9	hSpCas9	negative selection	4120507
1716599	1716622	17	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.21690853552549416	[3]	[1,1]	-5	hSpCas9	positive selection	4182384
1716622	1716645	17	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	1.474019592319157	[1]	[8,1]	9	hSpCas9	positive selection	4182385
1716599	1716622	17	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.5347950922667316	[2]	[4,1,0,0]	3	hSpCas9	positive selection	4246406
1716622	1716645	17	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.33252893711972786	[3]	[2,0,1,0]	-5	hSpCas9	positive selection	4246407
1725150	1725173	17	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.29877871461025746	[2]	[2,2]	6	hSpCas9	positive selection	4307805
1716599	1716622	17	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.08287450716746793	[2]	[2,1]	-2	hSpCas9	positive selection	4372052
1716622	1716645	17	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.4867703238597997	[3]	[2,0]	-8	hSpCas9	positive selection	4372053
1716814	1716837	17	+	27661255	K562	viability	GGGCAGAGCGTCAGCCCCCAGGG	WDR81	ENSG00000167716	0.18889416304332088	[592,679]	[670,498]	6	dCas9-KRAB	negative selection	5522753
1725066	1725089	17	+	27661255	K562	viability	GGGACCTGAGCATCGATCCCAGG	WDR81	ENSG00000167716	0.08724305967642798	[1276,1270]	[1179,996]	3	dCas9-KRAB	negative selection	5522754
1716599	1716622	17	-	27661255	K562	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.126935238343441	[160,80]	[95,115]	4	dCas9-KRAB	negative selection	5522755
1716606	1716629	17	-	27661255	K562	viability	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.1393021314577716	[245,344]	[279,239]	5	dCas9-KRAB	negative selection	5522756
1724777	1724800	17	-	27661255	K562	viability	GGGGCGCGCTTACCCCTCCGCGG	WDR81	ENSG00000167716	0.5047563730977552	[234,428]	[448,306]	9	dCas9-KRAB	negative selection	5522757
1724796	1724819	17	-	27661255	K562	viability	GCGGCGAAGAGGCGGACGGGGGG	WDR81	ENSG00000167716	-0.2516149765443597	[441,478]	[368,256]	-6	dCas9-KRAB	negative selection	5522758
1724799	1724822	17	-	27661255	K562	viability	GCGGCGGCGAAGAGGCGGACGGG	WDR81	ENSG00000167716	0.07874415000408516	[667,843]	[741,543]	2	dCas9-KRAB	negative selection	5522759
1725154	1725177	17	-	27661255	K562	viability	GGGGCAGCCGGCGATCGCGGAGG	WDR81	ENSG00000167716	-0.10687640605542031	[843,752]	[660,535]	-4	dCas9-KRAB	negative selection	5522760
1725173	1725196	17	-	27661255	K562	viability	GCGCGGGGACAGGGTCCCAGGGG	WDR81	ENSG00000167716	-0.20157259017187568	[229,380]	[205,213]	-6	dCas9-KRAB	negative selection	5522761
1725150	1725173	17	-	27260156	BXPC3	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.255531292287792	[281]	[301,288,406,426]	5	hSpCas9	negative selection	5580265
1716599	1716622	17	-	27260156	BXPC3	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.06627111270774716	[416]	[322,319,552,494]	-1	hSpCas9	negative selection	5644512
1716622	1716645	17	-	27260156	BXPC3	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.4097996379204857	[560]	[426,493,369,472]	-7	hSpCas9	negative selection	5644513
1725150	1725173	17	-	27260156	A673	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.20277946603027086	[281]	[392,326,398,443]	5	hSpCas9	negative selection	5701516
1716599	1716622	17	-	27260156	A673	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.14112061824750338	[416]	[474,414,452,476]	-4	hSpCas9	negative selection	5765763
1716622	1716645	17	-	27260156	A673	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.5380530463208821	[560]	[528,466,456,405]	-8	hSpCas9	negative selection	5765764
1725150	1725173	17	-	27260156	A375	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	-0.035011691941779	[281]	[439,340,312,207]	0	hSpCas9	negative selection	5822767
1716599	1716622	17	-	27260156	A375	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.10922496163647882	[416]	[337,657,409,428]	-1	hSpCas9	negative selection	5887014
1716622	1716645	17	-	27260156	A375	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.13565101831956816	[560]	[660,706,690,367]	-2	hSpCas9	negative selection	5887015
1725150	1725173	17	-	27260156	COLO741	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.22547245789048587	[281]	[472,398,396]	5	hSpCas9	negative selection	5944018
1716599	1716622	17	-	27260156	COLO741	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.1550677205299783	[416]	[399,577,451]	-3	hSpCas9	negative selection	6008265
1716622	1716645	17	-	27260156	COLO741	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.452142246307535	[560]	[558,454,556]	-7	hSpCas9	negative selection	6008266
1725150	1725173	17	-	27260156	CAL120	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.129795434887911	[281]	[355,435,355]	2	hSpCas9	negative selection	6065269
1716599	1716622	17	-	27260156	CAL120	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.8914073773662101	[416]	[270,410,157]	-8	hSpCas9	negative selection	6129516
1716622	1716645	17	-	27260156	CAL120	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.6432275964953951	[560]	[250,262,790]	-7	hSpCas9	negative selection	6129517
1725150	1725173	17	-	27260156	CADOES1	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.1330774540861045	[281]	[249,220,274,408]	2	hSpCas9	negative selection	6186520
1716599	1716622	17	-	27260156	CADOES1	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.23116748477441038	[416]	[596,296,629,289]	4	hSpCas9	negative selection	6250767
1716622	1716645	17	-	27260156	CADOES1	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.6089989424566419	[560]	[315,331,286,436]	-8	hSpCas9	negative selection	6250768
1725150	1725173	17	-	27260156	EWS502	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.5955368240694354	[281]	[359,416,572,468]	8	hSpCas9	negative selection	6307771
1716599	1716622	17	-	27260156	EWS502	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.23998648781891446	[416]	[381,288,502,320]	-4	hSpCas9	negative selection	6372018
1716622	1716645	17	-	27260156	EWS502	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.764294606785252	[560]	[185,402,469,358]	-8	hSpCas9	negative selection	6372019
1725150	1725173	17	-	27260156	EW8	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.20278591333494178	[281]	[222,306,263,252]	4	hSpCas9	negative selection	6429022
1716599	1716622	17	-	27260156	EW8	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.08064936154980064	[416]	[343,335,301,453]	1	hSpCas9	negative selection	6493269
1716622	1716645	17	-	27260156	EW8	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.37400303718715855	[560]	[438,305,433,218]	-6	hSpCas9	negative selection	6493270
1725150	1725173	17	-	27260156	CORL105	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.3217359258208201	[281]	[531,372,471,287]	6	hSpCas9	negative selection	6550273
1716599	1716622	17	-	27260156	CORL105	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.24352732301092023	[416]	[324,455,435,431]	-4	hSpCas9	negative selection	6614520
1716622	1716645	17	-	27260156	CORL105	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.6272714333175295	[560]	[336,465,477,423]	-8	hSpCas9	negative selection	6614521
1725150	1725173	17	-	27260156	HS294T	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.29240919182858877	[281]	[162,110,111,147]	4	hSpCas9	negative selection	6671524
1716599	1716622	17	-	27260156	HS294T	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.09560975014670742	[416]	[114,138,111,258]	-1	hSpCas9	negative selection	6735771
1716622	1716645	17	-	27260156	HS294T	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.23852259966246575	[560]	[248,100,213,163]	-3	hSpCas9	negative selection	6735772
1725150	1725173	17	-	27260156	HCC44	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.25785698225927095	[281]	[352,422,493,266]	4	hSpCas9	negative selection	6792775
1716599	1716622	17	-	27260156	HCC44	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.43429590648441596	[416]	[353,239,406,415]	-6	hSpCas9	negative selection	6857022
1716622	1716645	17	-	27260156	HCC44	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.49899810301240055	[560]	[541,446,304,480]	-6	hSpCas9	negative selection	6857023
1725150	1725173	17	-	27260156	G402	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.40521646712472303	[281]	[514,253,236,794]	5	hSpCas9	negative selection	6914026
1716599	1716622	17	-	27260156	G402	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.12731197616457363	[416]	[790,177,439,481]	-2	hSpCas9	negative selection	6978273
1716622	1716645	17	-	27260156	G402	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	0.674348296171585	[560]	[676,2377,376,954]	8	hSpCas9	negative selection	6978274
1725150	1725173	17	-	27260156	L33	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.41846019591804395	[281]	[378,205,234,252]	8	hSpCas9	negative selection	7035277
1716599	1716622	17	-	27260156	L33	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.3266993085181608	[416]	[304,134,286,240]	-6	hSpCas9	negative selection	7099524
1716622	1716645	17	-	27260156	L33	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.6591259686683755	[560]	[365,151,196,369]	-9	hSpCas9	negative selection	7099525
1725150	1725173	17	-	27260156	K562	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.03207248124106121	[281]	[172,114,263,434]	0	hSpCas9	negative selection	7156528
1716599	1716622	17	-	27260156	K562	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.394061553990948	[416]	[463,309,784,384]	5	hSpCas9	negative selection	7220775
1716622	1716645	17	-	27260156	K562	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.6756339373050632	[560]	[559,194,375,147]	-7	hSpCas9	negative selection	7220776
1725150	1725173	17	-	27260156	HT29	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.45984865363009897	[281]	[463,639,433,370]	8	hSpCas9	negative selection	7277779
1716599	1716622	17	-	27260156	HT29	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.14754920381970316	[416]	[584,434,428,393]	-3	hSpCas9	negative selection	7342026
1716622	1716645	17	-	27260156	HT29	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.6534045807734867	[560]	[575,429,402,343]	-8	hSpCas9	negative selection	7342027
1725150	1725173	17	-	27260156	MHHES1	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.0505401897264659	[281]	[320,285,346,344]	0	hSpCas9	negative selection	7399030
1716599	1716622	17	-	27260156	MHHES1	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.2775528966622178	[416]	[454,486,167,435]	-5	hSpCas9	negative selection	7463277
1716622	1716645	17	-	27260156	MHHES1	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	0.15936010539255457	[560]	[724,560,967,572]	3	hSpCas9	negative selection	7463278
1725150	1725173	17	-	27260156	MEWO	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.3741712902542193	[281]	[368,342,318]	7	hSpCas9	negative selection	7520281
1716599	1716622	17	-	27260156	MEWO	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.31410046795522195	[416]	[268,242,420]	-6	hSpCas9	negative selection	7584528
1716622	1716645	17	-	27260156	MEWO	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.3705276037842355	[560]	[486,307,438]	-7	hSpCas9	negative selection	7584529
1725150	1725173	17	-	27260156	LNCAPCLONEFGC	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.23887554862527427	[281]	[198,327,342,341]	4	hSpCas9	negative selection	7641532
1716599	1716622	17	-	27260156	LNCAPCLONEFGC	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.008757160279665027	[416]	[317,323,542,363]	0	hSpCas9	negative selection	7705779
1716622	1716645	17	-	27260156	LNCAPCLONEFGC	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.665181475818671	[560]	[296,385,348,249]	-7	hSpCas9	negative selection	7705780
1725150	1725173	17	-	27260156	PANC0327	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.3640169573342002	[281]	[469,396,273,150]	5	hSpCas9	negative selection	7762783
1716599	1716622	17	-	27260156	PANC0327	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.1824067888373394	[416]	[268,464,405,522]	2	hSpCas9	negative selection	7827030
1716622	1716645	17	-	27260156	PANC0327	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.21641174359110446	[560]	[459,265,410,601]	-3	hSpCas9	negative selection	7827031
1725150	1725173	17	-	27260156	NCIH2009	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.7482078745003437	[281]	[741,668,588]	8	hSpCas9	negative selection	7884034
1716599	1716622	17	-	27260156	NCIH2009	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.07677182756226034	[416]	[712,713,432]	1	hSpCas9	negative selection	7948281
1716622	1716645	17	-	27260156	NCIH2009	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.3285927898236986	[560]	[627,577,666]	-4	hSpCas9	negative selection	7948282
1725150	1725173	17	-	27260156	NCIH1373	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.6896969006140647	[281]	[634,415,368,172]	7	hSpCas9	negative selection	8005285
1716599	1716622	17	-	27260156	NCIH1373	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.36383962732575226	[416]	[334,262,396,122]	-4	hSpCas9	negative selection	8069532
1716622	1716645	17	-	27260156	NCIH1373	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.7694641072652043	[560]	[519,376,162,116]	-6	hSpCas9	negative selection	8069533
1725150	1725173	17	-	27260156	PATU8902	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.9883322072756466	[281]	[823,707,637,1002]	9	hSpCas9	negative selection	8126536
1716599	1716622	17	-	27260156	PATU8902	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.07745391522950631	[416]	[548,717,559,636]	0	hSpCas9	negative selection	8190783
1716622	1716645	17	-	27260156	PATU8902	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.3489738185693258	[560]	[486,504,463,1089]	-3	hSpCas9	negative selection	8190784
1725150	1725173	17	-	27260156	PANC1	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.10571415792095795	[281]	[271,352,235,204]	1	hSpCas9	negative selection	8247787
1716599	1716622	17	-	27260156	PANC1	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.036255256971429034	[416]	[382,438,302,353]	0	hSpCas9	negative selection	8312034
1716622	1716645	17	-	27260156	PANC1	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.49996472748096044	[560]	[407,328,309,310]	-6	hSpCas9	negative selection	8312035
1725150	1725173	17	-	27260156	PANC0813	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.7342044476026373	[281]	[551,480,556,609]	9	hSpCas9	negative selection	8369038
1716599	1716622	17	-	27260156	PANC0813	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.05354682540491559	[416]	[599,479,408,412]	-1	hSpCas9	negative selection	8433285
1716622	1716645	17	-	27260156	PANC0813	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.5699342345366916	[560]	[612,431,285,457]	-7	hSpCas9	negative selection	8433286
1725150	1725173	17	-	27260156	RDES	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.4278359783021632	[281]	[343,430,518,465]	6	hSpCas9	negative selection	8490289
1716599	1716622	17	-	27260156	RDES	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.030335113402792768	[416]	[392,575,462,528]	0	hSpCas9	negative selection	8554536
1716622	1716645	17	-	27260156	RDES	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.2582717533029141	[560]	[498,506,435,735]	-4	hSpCas9	negative selection	8554537
1725150	1725173	17	-	27260156	PC3	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.08200221125935914	[281]	[207,295,540,244]	1	hSpCas9	negative selection	8611540
1716599	1716622	17	-	27260156	PC3	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.12238409815198453	[416]	[283,324,485,479]	-3	hSpCas9	negative selection	8675787
1716622	1716645	17	-	27260156	PC3	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.5256073633232895	[560]	[242,463,568,367]	-8	hSpCas9	negative selection	8675788
1725150	1725173	17	-	27260156	PATU8988T	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.4662045098088841	[281]	[468,409,279,348]	7	hSpCas9	negative selection	8732791
1716599	1716622	17	-	27260156	PATU8988T	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.07472677547678594	[416]	[400,387,481,421]	1	hSpCas9	negative selection	8797038
1716622	1716645	17	-	27260156	PATU8988T	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.0722261777558438	[560]	[469,577,488,532]	-1	hSpCas9	negative selection	8797039
1725150	1725173	17	-	27260156	T47D	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.39269796697684173	[281]	[457,425,409,431]	8	hSpCas9	negative selection	8854042
1716599	1716622	17	-	27260156	T47D	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.2562882796813415	[416]	[442,415,499,260]	-5	hSpCas9	negative selection	8918289
1716622	1716645	17	-	27260156	T47D	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.4113820127064409	[560]	[477,465,490,533]	-7	hSpCas9	negative selection	8918290
1725150	1725173	17	-	27260156	SU8686	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.4620718822721964	[281]	[333,362,370,495]	7	hSpCas9	negative selection	8975293
1716599	1716622	17	-	27260156	SU8686	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.17776332488633279	[416]	[321,373,272,515]	-3	hSpCas9	negative selection	9039540
1716622	1716645	17	-	27260156	SU8686	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.4283245517907125	[560]	[303,487,416,449]	-6	hSpCas9	negative selection	9039541
1725150	1725173	17	-	27260156	SKES1	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.46832546552608245	[281]	[353,531,371,315]	8	hSpCas9	negative selection	9096544
1716599	1716622	17	-	27260156	SKES1	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.14301165401944066	[416]	[425,400,366,324]	-3	hSpCas9	negative selection	9160791
1716622	1716645	17	-	27260156	SKES1	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.4741074680638818	[560]	[570,354,388,319]	-8	hSpCas9	negative selection	9160792
1725150	1725173	17	-	27260156	TOV112D	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.24465994465280982	[281]	[314,621,350,124]	5	hSpCas9	negative selection	9217795
1716599	1716622	17	-	27260156	TOV112D	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.013197239412469641	[416]	[396,640,342,357]	0	hSpCas9	negative selection	9282042
1716622	1716645	17	-	27260156	TOV112D	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.5942552057160346	[560]	[289,549,387,298]	-8	hSpCas9	negative selection	9282043
1725150	1725173	17	-	27260156	TC71	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.17609424462201517	[281]	[294,390,271,415]	4	hSpCas9	negative selection	9339046
1716599	1716622	17	-	27260156	TC71	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	-0.2818661470392665	[416]	[357,423,325,363]	-6	hSpCas9	negative selection	9403293
1716622	1716645	17	-	27260156	TC71	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.6123488327963216	[560]	[331,371,485,380]	-9	hSpCas9	negative selection	9403294
1725150	1725173	17	-	27260156	TC32	viability	CAGCCGGCGATCGCGGAGGCTGG	WDR81	ENSG00000167716	0.2725086893969588	[281]	[228,354,386,296]	5	hSpCas9	negative selection	9460297
1716599	1716622	17	-	27260156	TC32	viability	GTTCTGGGAACGACGGTGTCAGG	WDR81	ENSG00000167716	0.11695874825796915	[416]	[510,419,344,367]	2	hSpCas9	negative selection	9524544
1716622	1716645	17	-	27260156	TC32	viability	TGCCAACTCACAGAGCGCGCTGG	WDR81	ENSG00000167716	-0.30656953582541346	[560]	[429,371,534,376]	-5	hSpCas9	negative selection	9524545
1716606	1716629	17	-	27869803	HPAFII	viability after 27 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	-0.8545202699357809	[851]	[316,189,NaN]	-6	hSpCas9	negative selection	9559279
1725115	1725138	17	-	27869803	HPAFII	viability after 27 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	0.3634175117054006	[456]	[55,519,NaN]	3	hSpCas9	negative selection	9559288
1716606	1716629	17	-	27869803	HPAFII	viability after 15 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	-0.5791402441391593	[851]	[771,513,NaN]	-6	hSpCas9	negative selection	9641728
1725115	1725138	17	-	27869803	HPAFII	viability after 15 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	0.17804972039932232	[456]	[374,667,NaN]	2	hSpCas9	negative selection	9641737
1716606	1716629	17	-	27869803	ASPC1	viability after 36 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.1307713197985867	[2140]	[458,1380,614]	1	hSpCas9	negative selection	9724177
1725115	1725138	17	-	27869803	ASPC1	viability after 36 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	-0.13875909034537626	[1121]	[496,468,162]	-1	hSpCas9	negative selection	9724186
1716606	1716629	17	-	27869803	PATU8988S	viability after 35 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.24166710878247577	[2116]	[1053,961,NaN]	2	hSpCas9	negative selection	9806626
1725115	1725138	17	-	27869803	PATU8988S	viability after 35 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	0.07441264220233479	[974]	[398,427,NaN]	0	hSpCas9	negative selection	9806635
1716606	1716629	17	-	27869803	PATU8988S	viability after 31 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	0.06147045563065512	[2116]	[901,853,NaN]	0	hSpCas9	negative selection	9889075
1725115	1725138	17	-	27869803	PATU8988S	viability after 31 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	0.13187232600269894	[974]	[359,509,NaN]	1	hSpCas9	negative selection	9889084
1716606	1716629	17	-	27869803	HPAFII	viability after 35 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	-0.8570607517291063	[851]	[247,226,NaN]	-5	hSpCas9	negative selection	9971524
1725115	1725138	17	-	27869803	HPAFII	viability after 35 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	0.49544837414177345	[456]	[42,644,NaN]	3	hSpCas9	negative selection	9971533
1716606	1716629	17	-	27869803	HPAFII	viability after 31 days	GCGCTGGGTTCTGGGAACGACGG	WDR81	ENSG00000167716	-0.7654093119498104	[851]	[365,188,NaN]	-5	hSpCas9	negative selection	10053973
1725115	1725138	17	-	27869803	HPAFII	viability after 31 days	CAGGCACTAGGGCCACCACGTGG	WDR81	ENSG00000167716	0.5437468209673781	[456]	[24,753,NaN]	4	hSpCas9	negative selection	10053982