Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 7486
• Symbol: WRN
• Description: WRN RecQ like helicase

DataSource: http://genomecrispr.dkfz.de/#!/results/WRN

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
31076266	31076289	8	+	26472758	Jiyoye	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	4.577100382948185	[0]	[17]	9	hSpCas9	negative selection	182245
31147425	31147448	8	-	26472758	Jiyoye	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.17411603511756946	[180]	[153]	1	hSpCas9	negative selection	182246
31111764	31111787	8	-	26472758	Jiyoye	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	2.161156952687681	[58]	[198]	9	hSpCas9	negative selection	182247
31147438	31147461	8	+	26472758	Jiyoye	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	0.3140659771143921	[143]	[134]	2	hSpCas9	negative selection	182248
31058464	31058487	8	+	26472758	Jiyoye	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	-0.026240647087824975	[157]	[116]	0	hSpCas9	negative selection	182249
31059185	31059208	8	-	26472758	Jiyoye	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	-0.08262988617494271	[197]	[140]	0	hSpCas9	negative selection	182250
31064426	31064449	8	-	26472758	Jiyoye	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	-0.6636203966039865	[354]	[168]	-5	hSpCas9	negative selection	182251
31067169	31067192	8	-	26472758	Jiyoye	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	-0.11876660540308226	[454]	[315]	-1	hSpCas9	negative selection	182252
31116433	31116456	8	+	26472758	Jiyoye	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	-0.6125428531086319	[220]	[108]	-4	hSpCas9	negative selection	182253
31141482	31141505	8	+	26472758	Jiyoye	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	-2.177787119215283	[185]	[30]	-8	hSpCas9	negative selection	182254
31076266	31076289	8	+	26472758	KBM7	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	0.22332747924933027	[80,68]	[30,49]	2	hSpCas9	negative selection	373363
31147425	31147448	8	-	26472758	KBM7	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.35062269446014493	[1015,842]	[522,582]	4	hSpCas9	negative selection	373364
31111764	31111787	8	-	26472758	KBM7	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	0.006710591896113061	[759,417]	[302,242]	0	hSpCas9	negative selection	373365
31147438	31147461	8	+	26472758	KBM7	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-0.42702740008051854	[666,476]	[185,207]	-4	hSpCas9	negative selection	373366
31058464	31058487	8	+	26472758	KBM7	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	0.6008669886067539	[678,579]	[617,294]	6	hSpCas9	negative selection	373367
31059185	31059208	8	-	26472758	KBM7	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	0.6058813315489122	[562,497]	[537,236]	6	hSpCas9	negative selection	373368
31064426	31064449	8	-	26472758	KBM7	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	0.5713691371456473	[1382,1297]	[1266,643]	6	hSpCas9	negative selection	373369
31067169	31067192	8	-	26472758	KBM7	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.4365696578881466	[1379,1788]	[1035,1017]	5	hSpCas9	negative selection	373370
31116433	31116456	8	+	26472758	KBM7	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	0.051520668264633085	[664,796]	[356,364]	0	hSpCas9	negative selection	373371
31141482	31141505	8	+	26472758	KBM7	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	0.004946055074232958	[425,410]	[300,105]	0	hSpCas9	negative selection	373372
31076266	31076289	8	+	26472758	Raji	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	0.46352734559887465	[49]	[15]	4	hSpCas9	negative selection	564481
31147425	31147448	8	-	26472758	Raji	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.18027605605561803	[520]	[136]	1	hSpCas9	negative selection	564482
31111764	31111787	8	-	26472758	Raji	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	0.43753213706593014	[244]	[76]	4	hSpCas9	negative selection	564483
31147438	31147461	8	+	26472758	Raji	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-1.0441042178120366	[310]	[34]	-6	hSpCas9	negative selection	564484
31058464	31058487	8	+	26472758	Raji	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	0.21076127521890797	[349]	[93]	2	hSpCas9	negative selection	564485
31059185	31059208	8	-	26472758	Raji	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	0.9413735839346702	[275]	[122]	8	hSpCas9	negative selection	564486
31064426	31064449	8	-	26472758	Raji	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	-0.651315580739888	[757]	[111]	-5	hSpCas9	negative selection	564487
31067169	31067192	8	-	26472758	Raji	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.5163719899796382	[716]	[237]	5	hSpCas9	negative selection	564488
31116433	31116456	8	+	26472758	Raji	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	0.33614803912264735	[354]	[103]	3	hSpCas9	negative selection	564489
31141482	31141505	8	+	26472758	Raji	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	-0.46307939565244166	[296]	[49]	-4	hSpCas9	negative selection	564490
31076266	31076289	8	+	26472758	K562	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	0.8563482759878722	[52]	[80]	7	hSpCas9	negative selection	755599
31147425	31147448	8	-	26472758	K562	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.39136194730268703	[913]	[1011]	3	hSpCas9	negative selection	755600
31111764	31111787	8	-	26472758	K562	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	0.1319439984080344	[439]	[406]	1	hSpCas9	negative selection	755601
31147438	31147461	8	+	26472758	K562	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-0.7822711504182845	[490]	[240]	-4	hSpCas9	negative selection	755602
31058464	31058487	8	+	26472758	K562	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	0.7048215311542123	[539]	[742]	6	hSpCas9	negative selection	755603
31059185	31059208	8	-	26472758	K562	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	1.0388885235173682	[481]	[835]	8	hSpCas9	negative selection	755604
31064426	31064449	8	-	26472758	K562	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	0.9826997493602008	[876]	[1462]	8	hSpCas9	negative selection	755605
31067169	31067192	8	-	26472758	K562	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.7566780346579585	[1247]	[1779]	6	hSpCas9	negative selection	755606
31116433	31116456	8	+	26472758	K562	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	0.36286018496398653	[560]	[608]	3	hSpCas9	negative selection	755607
31141482	31141505	8	+	26472758	K562	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	0.313523376006447	[427]	[448]	2	hSpCas9	negative selection	755608
31090511	31090534	8	+	26627737	DLD1	viability	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	-0.4725664182609396	[310]	[98,63,49]	-5	hSpCas9	negative selection	839353
31100934	31100957	8	+	26627737	DLD1	viability	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-1.1141815186144002	[465]	[54,94,54]	-7	hSpCas9	negative selection	839354
31116449	31116472	8	-	26627737	DLD1	viability	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-1.1911237590424473	[722]	[78,108,107]	-8	hSpCas9	negative selection	839355
31120308	31120331	8	+	26627737	DLD1	viability	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-0.455167092688197	[1065]	[290,262,184]	-4	hSpCas9	negative selection	839356
31141460	31141483	8	+	26627737	DLD1	viability	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	0.2958202459989668	[568]	[228,238,191]	3	hSpCas9	negative selection	839357
31157409	31157432	8	+	26627737	DLD1	viability	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-0.4147960158428422	[945]	[425,118,129]	-4	hSpCas9	negative selection	839358
31090511	31090534	8	+	26627737	GBM cells	viability after 5 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	-0.28099521512924897	[144]	[64,62]	-4	hSpCas9	negative selection	921668
31100934	31100957	8	+	26627737	GBM cells	viability after 5 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	0.06433748409305728	[320]	[178,180]	1	hSpCas9	negative selection	921669
31116449	31116472	8	-	26627737	GBM cells	viability after 5 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	0.5484166278015523	[152]	[101,137]	7	hSpCas9	negative selection	921670
31120308	31120331	8	+	26627737	GBM cells	viability after 5 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	0.1305052330685984	[401]	[212,258]	2	hSpCas9	negative selection	921671
31141460	31141483	8	+	26627737	GBM cells	viability after 5 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	0.4086700314176679	[209]	[167,130]	6	hSpCas9	negative selection	921672
31157409	31157432	8	+	26627737	GBM cells	viability after 5 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	0.17593874520999586	[495]	[299,300]	2	hSpCas9	negative selection	921673
31090511	31090534	8	+	26627737	GBM cells	viability after 13 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	-0.6041140369909637	[144]	[48,53]	-6	hSpCas9	negative selection	1003983
31100934	31100957	8	+	26627737	GBM cells	viability after 13 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-0.3707360736885562	[320]	[153,118]	-4	hSpCas9	negative selection	1003984
31116449	31116472	8	-	26627737	GBM cells	viability after 13 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	0.44461258611578097	[152]	[139,90]	5	hSpCas9	negative selection	1003985
31120308	31120331	8	+	26627737	GBM cells	viability after 13 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-0.037479783617039186	[401]	[297,142]	0	hSpCas9	negative selection	1003986
31141460	31141483	8	+	26627737	GBM cells	viability after 13 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	0.22982435471872806	[209]	[126,138]	3	hSpCas9	negative selection	1003987
31157409	31157432	8	+	26627737	GBM cells	viability after 13 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	0.3343306859057156	[495]	[394,293]	4	hSpCas9	negative selection	1003988
31090511	31090534	8	+	26627737	GBM cells	viability after 21 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	0.019042748012196298	[144]	[83,75]	0	hSpCas9	negative selection	1086298
31100934	31100957	8	+	26627737	GBM cells	viability after 21 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	0.27216543863170983	[320]	[219,201]	3	hSpCas9	negative selection	1086299
31116449	31116472	8	-	26627737	GBM cells	viability after 21 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	0.04612480954398235	[152]	[89,81]	0	hSpCas9	negative selection	1086300
31120308	31120331	8	+	26627737	GBM cells	viability after 21 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-0.1725590682286562	[401]	[198,188]	-1	hSpCas9	negative selection	1086301
31141460	31141483	8	+	26627737	GBM cells	viability after 21 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	0.5417995340006055	[209]	[163,167]	5	hSpCas9	negative selection	1086302
31157409	31157432	8	+	26627737	GBM cells	viability after 21 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	0.03188731170862691	[495]	[263,285]	0	hSpCas9	negative selection	1086303
31090511	31090534	8	+	26627737	RPE1	viability after 9 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	1.0918923686875395	[273]	[167,201]	6	hSpCas9	negative selection	1168613
31100934	31100957	8	+	26627737	RPE1	viability after 9 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	0.5552260742739867	[466]	[130,322]	4	hSpCas9	negative selection	1168614
31116449	31116472	8	-	26627737	RPE1	viability after 9 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-0.7171139709368056	[835]	[170,143]	-5	hSpCas9	negative selection	1168615
31120308	31120331	8	+	26627737	RPE1	viability after 9 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	0.034866560989089565	[761]	[160,351]	0	hSpCas9	negative selection	1168616
31141460	31141483	8	+	26627737	RPE1	viability after 9 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-0.07557738294969907	[1251]	[319,438]	0	hSpCas9	negative selection	1168617
31157409	31157432	8	+	26627737	RPE1	viability after 9 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-0.23527200895367129	[1668]	[356,555]	-2	hSpCas9	negative selection	1168618
31090511	31090534	8	+	26627737	RPE1	viability after 12 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	0.9893148364003355	[273]	[167,122]	6	hSpCas9	negative selection	1250928
31100934	31100957	8	+	26627737	RPE1	viability after 12 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	0.6567312878352244	[466]	[173,222]	4	hSpCas9	negative selection	1250929
31116449	31116472	8	-	26627737	RPE1	viability after 12 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-0.9925286063750408	[835]	[108,116]	-6	hSpCas9	negative selection	1250930
31120308	31120331	8	+	26627737	RPE1	viability after 12 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	0.40734852132837873	[761]	[288,252]	2	hSpCas9	negative selection	1250931
31141460	31141483	8	+	26627737	RPE1	viability after 12 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	0.18233394495961264	[1251]	[149,626]	1	hSpCas9	negative selection	1250932
31157409	31157432	8	+	26627737	RPE1	viability after 12 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-0.361455497837576	[1668]	[315,383]	-2	hSpCas9	negative selection	1250933
31090511	31090534	8	+	26627737	RPE1	viability after 15 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	1.2244640582086384	[273]	[230,132]	7	hSpCas9	negative selection	1333243
31100934	31100957	8	+	26627737	RPE1	viability after 15 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	0.26208822358273287	[466]	[190,126]	1	hSpCas9	negative selection	1333244
31116449	31116472	8	-	26627737	RPE1	viability after 15 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-0.673777007140158	[835]	[21,269]	-4	hSpCas9	negative selection	1333245
31120308	31120331	8	+	26627737	RPE1	viability after 15 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	0.7649960522271915	[761]	[517,219]	5	hSpCas9	negative selection	1333246
31141460	31141483	8	+	26627737	RPE1	viability after 15 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-0.008893992131414064	[1251]	[183,513]	0	hSpCas9	negative selection	1333247
31157409	31157432	8	+	26627737	RPE1	viability after 15 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-1.092048057181753	[1668]	[194,246]	-6	hSpCas9	negative selection	1333248
31090511	31090534	8	+	26627737	RPE1	viability after 18 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	1.0540650595981247	[273]	[139,167]	6	hSpCas9	negative selection	1415558
31100934	31100957	8	+	26627737	RPE1	viability after 18 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	0.39545051128273967	[466]	[129,203]	2	hSpCas9	negative selection	1415559
31116449	31116472	8	-	26627737	RPE1	viability after 18 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-0.5160754876425663	[835]	[179,133]	-3	hSpCas9	negative selection	1415560
31120308	31120331	8	+	26627737	RPE1	viability after 18 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-0.22680230995202372	[761]	[123,230]	-1	hSpCas9	negative selection	1415561
31141460	31141483	8	+	26627737	RPE1	viability after 18 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	0.18839956736383412	[1251]	[224,555]	1	hSpCas9	negative selection	1415562
31157409	31157432	8	+	26627737	RPE1	viability after 18 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-0.3434632860446749	[1668]	[310,401]	-2	hSpCas9	negative selection	1415563
31090511	31090534	8	+	26627737	HeLa	viability after 8 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	1.3730290709328303	[60]	[117,28,69]	8	hSpCas9	negative selection	1497873
31100934	31100957	8	+	26627737	HeLa	viability after 8 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-1.275012984784053	[960]	[294,102,148]	-8	hSpCas9	negative selection	1497874
31116449	31116472	8	-	26627737	HeLa	viability after 8 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-0.6254737523498705	[424]	[114,159,85]	-6	hSpCas9	negative selection	1497875
31120308	31120331	8	+	26627737	HeLa	viability after 8 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	0.008080263337685412	[601]	[538,108,206]	0	hSpCas9	negative selection	1497876
31141460	31141483	8	+	26627737	HeLa	viability after 8 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-0.42806715383943605	[497]	[399,66,74]	-4	hSpCas9	negative selection	1497877
31157409	31157432	8	+	26627737	HeLa	viability after 8 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-0.8371930734212203	[1539]	[495,445,220]	-7	hSpCas9	negative selection	1497878
31090511	31090534	8	+	26627737	HeLa	viability after 12 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	2.1033094297099466	[60]	[128,141,50]	9	hSpCas9	negative selection	1580188
31100934	31100957	8	+	26627737	HeLa	viability after 12 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-1.876333508914528	[960]	[62,128,128]	-9	hSpCas9	negative selection	1580189
31116449	31116472	8	-	26627737	HeLa	viability after 12 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-0.5986439542322003	[424]	[141,84,124]	-5	hSpCas9	negative selection	1580190
31120308	31120331	8	+	26627737	HeLa	viability after 12 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-0.23576407577244246	[601]	[179,219,231]	-2	hSpCas9	negative selection	1580191
31141460	31141483	8	+	26627737	HeLa	viability after 12 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	0.6512676821568946	[497]	[442,220,319]	5	hSpCas9	negative selection	1580192
31157409	31157432	8	+	26627737	HeLa	viability after 12 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-1.0060057978492751	[1539]	[159,317,467]	-7	hSpCas9	negative selection	1580193
31090511	31090534	8	+	26627737	HeLa	viability after 15 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	2.0396033284563924	[60]	[100,118,84]	9	hSpCas9	negative selection	1662503
31100934	31100957	8	+	26627737	HeLa	viability after 15 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-1.9304329507209306	[960]	[89,55,166]	-9	hSpCas9	negative selection	1662504
31116449	31116472	8	-	26627737	HeLa	viability after 15 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-0.7219545999224234	[424]	[66,72,180]	-6	hSpCas9	negative selection	1662505
31120308	31120331	8	+	26627737	HeLa	viability after 15 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-0.1688770086086535	[601]	[201,260,188]	-1	hSpCas9	negative selection	1662506
31141460	31141483	8	+	26627737	HeLa	viability after 15 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-0.3133280746789834	[497]	[83,188,221]	-3	hSpCas9	negative selection	1662507
31157409	31157432	8	+	26627737	HeLa	viability after 15 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-1.1604520290211744	[1539]	[213,314,315]	-7	hSpCas9	negative selection	1662508
31090511	31090534	8	+	26627737	HeLa	viability after 18 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	2.0381804785307547	[60]	[63,102,84]	9	hSpCas9	negative selection	1744818
31100934	31100957	8	+	26627737	HeLa	viability after 18 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-1.942643587914383	[960]	[62,40,166]	-9	hSpCas9	negative selection	1744819
31116449	31116472	8	-	26627737	HeLa	viability after 18 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-0.7298352620477877	[424]	[44,58,180]	-6	hSpCas9	negative selection	1744820
31120308	31120331	8	+	26627737	HeLa	viability after 18 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-0.15947417688739113	[601]	[139,213,188]	-1	hSpCas9	negative selection	1744821
31141460	31141483	8	+	26627737	HeLa	viability after 18 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-0.3213451576200669	[497]	[58,150,221]	-3	hSpCas9	negative selection	1744822
31157409	31157432	8	+	26627737	HeLa	viability after 18 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-1.174935159526109	[1539]	[137,260,315]	-8	hSpCas9	negative selection	1744823
31090511	31090534	8	+	26627737	HCT116	viability after 6 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	-0.14633742485816936	[380]	[144,3]	-1	hSpCas9	negative selection	1827133
31100934	31100957	8	+	26627737	HCT116	viability after 6 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-2.67201170711994	[800]	[2,28]	-9	hSpCas9	negative selection	1827134
31116449	31116472	8	-	26627737	HCT116	viability after 6 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-1.6333957243331594	[356]	[10,21]	-7	hSpCas9	negative selection	1827135
31120308	31120331	8	+	26627737	HCT116	viability after 6 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	0.02157735102184216	[682]	[302,1]	0	hSpCas9	negative selection	1827136
31141460	31141483	8	+	26627737	HCT116	viability after 6 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	0.11641299187262286	[718]	[273,38]	0	hSpCas9	negative selection	1827137
31157409	31157432	8	+	26627737	HCT116	viability after 6 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-0.7485914778836176	[1095]	[137,82]	-4	hSpCas9	negative selection	1827138
31090511	31090534	8	+	26627737	HCT116	viability after 8 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	0.2388540302197767	[137]	[143,104,21]	2	hSpCas9	negative selection	1909448
31100934	31100957	8	+	26627737	HCT116	viability after 8 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-1.9086259191637522	[123]	[28,24,0]	-9	hSpCas9	negative selection	1909449
31116449	31116472	8	-	26627737	HCT116	viability after 8 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-3.183156393852048	[597]	[0,53,52]	-9	hSpCas9	negative selection	1909450
31120308	31120331	8	+	26627737	HCT116	viability after 8 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-2.8738086429117677	[523]	[27,52,36]	-9	hSpCas9	negative selection	1909451
31141460	31141483	8	+	26627737	HCT116	viability after 8 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-0.8365225747534707	[311]	[69,92,124]	-8	hSpCas9	negative selection	1909452
31157409	31157432	8	+	26627737	HCT116	viability after 8 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-2.538920446757296	[766]	[74,52,89]	-9	hSpCas9	negative selection	1909453
31090511	31090534	8	+	26627737	HCT116	viability after 9 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	-1.1916102145855851	[380]	[67,25]	-7	hSpCas9	negative selection	1991763
31100934	31100957	8	+	26627737	HCT116	viability after 9 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-1.158552074557313	[800]	[6,165]	-7	hSpCas9	negative selection	1991764
31116449	31116472	8	-	26627737	HCT116	viability after 9 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-3.0472782241383745	[356]	[15,7]	-9	hSpCas9	negative selection	1991765
31120308	31120331	8	+	26627737	HCT116	viability after 9 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-1.7286834764898764	[682]	[49,58]	-8	hSpCas9	negative selection	1991766
31141460	31141483	8	+	26627737	HCT116	viability after 9 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	0.7374354472283638	[718]	[552,135]	5	hSpCas9	negative selection	1991767
31157409	31157432	8	+	26627737	HCT116	viability after 9 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-2.9369292324266087	[1095]	[59,20]	-9	hSpCas9	negative selection	1991768
31090511	31090534	8	+	26627737	HCT116	viability after 12 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	1.2450542912355032	[137]	[138,188,190]	8	hSpCas9	negative selection	2074078
31100934	31100957	8	+	26627737	HCT116	viability after 12 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-2.2380554479700896	[123]	[2,38,0]	-9	hSpCas9	negative selection	2074079
31116449	31116472	8	-	26627737	HCT116	viability after 12 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-3.31616283302985	[597]	[2,65,28]	-9	hSpCas9	negative selection	2074080
31120308	31120331	8	+	26627737	HCT116	viability after 12 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-3.882711909536502	[523]	[17,15,21]	-9	hSpCas9	negative selection	2074081
31141460	31141483	8	+	26627737	HCT116	viability after 12 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-1.6428235691320972	[311]	[75,74,4]	-9	hSpCas9	negative selection	2074082
31157409	31157432	8	+	26627737	HCT116	viability after 12 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-3.972115237543186	[766]	[54,5,12]	-9	hSpCas9	negative selection	2074083
31090511	31090534	8	+	26627737	HCT116	viability after 15 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	-0.1453409348257928	[137]	[63,74,74]	-1	hSpCas9	negative selection	2156393
31100934	31100957	8	+	26627737	HCT116	viability after 15 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-1.5357071679016834	[123]	[32,40,0]	-8	hSpCas9	negative selection	2156394
31116449	31116472	8	-	26627737	HCT116	viability after 15 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-2.9638529181326163	[597]	[5,41,78]	-9	hSpCas9	negative selection	2156395
31120308	31120331	8	+	26627737	HCT116	viability after 15 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-4.640671121516365	[523]	[17,13,4]	-9	hSpCas9	negative selection	2156396
31141460	31141483	8	+	26627737	HCT116	viability after 15 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-1.925596390665913	[311]	[60,19,61]	-9	hSpCas9	negative selection	2156397
31157409	31157432	8	+	26627737	HCT116	viability after 15 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-3.552650430753937	[766]	[65,5,43]	-9	hSpCas9	negative selection	2156398
31090511	31090534	8	+	26627737	HCT116	viability after 18 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	0.9785195347117199	[137]	[165,111,116]	7	hSpCas9	negative selection	2238708
31100934	31100957	8	+	26627737	HCT116	viability after 18 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-2.0566809486946775	[123]	[0,38,0]	-9	hSpCas9	negative selection	2238709
31116449	31116472	8	-	26627737	HCT116	viability after 18 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-2.6291281408810363	[597]	[3,5,136]	-9	hSpCas9	negative selection	2238710
31120308	31120331	8	+	26627737	HCT116	viability after 18 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-4.701671468072647	[523]	[4,21,0]	-9	hSpCas9	negative selection	2238711
31141460	31141483	8	+	26627737	HCT116	viability after 18 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-2.257850041565581	[311]	[53,18,21]	-9	hSpCas9	negative selection	2238712
31157409	31157432	8	+	26627737	HCT116	viability after 18 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-4.7470867167223165	[766]	[32,0,7]	-9	hSpCas9	negative selection	2238713
31033798	31033821	8	-	25494202	A375	resistance to PLX-4720 (puromycin)	ACACAGTACACATCAGCTCCGGG	WRN	ENSG00000165392	0.4633142940757931	[100,95]	[44,12]	2	dCas9-VP64	positive selection	2389619
31033824	31033847	8	-	25494202	A375	resistance to PLX-4720 (puromycin)	AGTACAAGCCGGCGCCTCCCCGG	WRN	ENSG00000165392	-1.2038692174930845	[145,177]	[10,19]	-7	dCas9-VP64	positive selection	2389620
31033877	31033900	8	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGTGTCTAGCCTGGATGCCTGGG	WRN	ENSG00000165392	2.615880692795137	[121,29]	[188,5]	8	dCas9-VP64	positive selection	2389621
31081884	31081907	8	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGCCTGTGGTCCCAGCTACTAGG	WRN	ENSG00000165392	-1.0019767452838857	[448,49]	[42,8]	-6	dCas9-VP64	positive selection	2399851
31074038	31074061	8	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCCGGAGTAGCTGGGACTACGGG	WRN	ENSG00000165392	-1.0701889682907664	[130,53]	[5,12]	-6	dCas9-VP64	positive selection	2415410
31033798	31033821	8	-	25494202	A375	resistance to PLX-4720 (zeocin)	ACACAGTACACATCAGCTCCGGG	WRN	ENSG00000165392	-0.06658822046841184	[566,177]	[176,60]	0	dCas9-VP64	positive selection	2484874
31033824	31033847	8	-	25494202	A375	resistance to PLX-4720 (zeocin)	AGTACAAGCCGGCGCCTCCCCGG	WRN	ENSG00000165392	-0.59037251112329	[203,72]	[42,17]	-6	dCas9-VP64	positive selection	2484875
31033877	31033900	8	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGTGTCTAGCCTGGATGCCTGGG	WRN	ENSG00000165392	-0.6909758185110337	[107,60]	[21,11]	-6	dCas9-VP64	positive selection	2484876
31081884	31081907	8	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGCCTGTGGTCCCAGCTACTAGG	WRN	ENSG00000165392	0.3516116254360768	[311,292]	[125,125]	3	dCas9-VP64	positive selection	2495106
31074038	31074061	8	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCCGGAGTAGCTGGGACTACGGG	WRN	ENSG00000165392	-0.20642758050950127	[20,72]	[9,15]	-2	dCas9-VP64	positive selection	2510665
31087782	31087805	8	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGAAAACCTCAATAGTGGCACGG	WRN	ENSG00000165392	-0.8990383848139591	[3,3]	[1,0]	-8	hSpCas9	positive selection	3032679
31080936	31080959	8	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CTAACATTGAGACTGAACTGAGG	WRN	ENSG00000165392	0.38370173421531373	[3,4]	[3,5]	7	hSpCas9	positive selection	3032680
31111618	31111641	8	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	-1.0933688683526175	[2,2]	[1,0]	-9	hSpCas9	positive selection	3032681
31090902	31090925	8	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TCTTCCATCAGAGAAATAAGGGG	WRN	ENSG00000165392	-0.0689833521306829	[5,5]	[4,3]	-1	hSpCas9	positive selection	3032682
31087782	31087805	8	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGAAAACCTCAATAGTGGCACGG	WRN	ENSG00000165392	-0.22756810577166348	[3,3]	[3,0]	-3	hSpCas9	positive selection	3100537
31080936	31080959	8	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CTAACATTGAGACTGAACTGAGG	WRN	ENSG00000165392	0.1329643385296652	[3,3]	[3,2]	2	hSpCas9	positive selection	3100538
31111618	31111641	8	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	-0.7504373748999014	[2,2]	[1,0]	-8	hSpCas9	positive selection	3100539
31090902	31090925	8	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TCTTCCATCAGAGAAATAAGGGG	WRN	ENSG00000165392	0.39164961865476483	[5,5]	[4,4]	6	hSpCas9	positive selection	3100540
31059211	31059234		-	24336571	A375	resistance to PLX after 7 days	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.6980282611360099	[6,6]	[4,2]	-9	hSpCas9	positive selection	3155859
31059248	31059271		-	24336571	A375	resistance to PLX after 7 days	CTTACCTAATATCTTCTGACAGG	WRN	ENSG00000165392	0.25104509628088956	[5,7]	[8,7]	7	hSpCas9	positive selection	3155860
31064413	31064436		+	24336571	A375	resistance to PLX after 7 days	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	-0.08758039668679918	[21,20]	[20,19]	-3	hSpCas9	positive selection	3155861
31059211	31059234		-	24336571	A375	resistance to PLX after 14 days	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.4913680078010675	[3,8]	[1,1]	-6	hSpCas9	positive selection	3213652
31059248	31059271		-	24336571	A375	resistance to PLX after 14 days	CTTACCTAATATCTTCTGACAGG	WRN	ENSG00000165392	0.4255084592648343	[4,9]	[5,2]	4	hSpCas9	positive selection	3213653
31064413	31064436		+	24336571	A375	resistance to PLX after 14 days	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	-1.5849257510918529	[28,24]	[3,2]	-9	hSpCas9	positive selection	3213654
31059211	31059234		-	24336571	A375	viability after 7 days	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.6317306123119003	[10]	[6,6]	-7	hSpCas9	negative selection	3271445
31059248	31059271		-	24336571	A375	viability after 7 days	CTTACCTAATATCTTCTGACAGG	WRN	ENSG00000165392	-1.230927150824012	[18]	[5,7]	-9	hSpCas9	negative selection	3271446
31064413	31064436		+	24336571	A375	viability after 7 days	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.42180208327225244	[16]	[21,20]	6	hSpCas9	negative selection	3271447
31059211	31059234		-	24336571	A375	viability after 14 days	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.6779978153852048	[10]	[3,8]	-7	hSpCas9	negative selection	3329238
31059248	31059271		-	24336571	A375	viability after 14 days	CTTACCTAATATCTTCTGACAGG	WRN	ENSG00000165392	-1.1736078723420138	[18]	[4,9]	-9	hSpCas9	negative selection	3329239
31064413	31064436		+	24336571	A375	viability after 14 days	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.7347013578610418	[16]	[28,24]	8	hSpCas9	negative selection	3329240
31059211	31059234	8	-	27383988	293T	resistance to West Nile virus (flavivirus)	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-1.0418818069414437	[314,314]	[0,0]	-7	hSpCas9	positive selection	3401574
31064972	31064995	8	+	27383988	293T	resistance to West Nile virus (flavivirus)	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.15929412848530838	[136,136]	[0,0]	0	hSpCas9	positive selection	3401575
31065042	31065065	8	+	27383988	293T	resistance to West Nile virus (flavivirus)	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	-0.9225828785690994	[289,289]	[0,0]	-6	hSpCas9	positive selection	3401576
31087781	31087804	8	+	26780180	HT29	viability (Avana library 4 designs)	AGAAAACCTCAATAGTGGCACGG	WRN	ENSG00000165392	1.14300787214655	[]	[]	4	hSpCas9	negative selection	3471935
31080935	31080958	8	+	26780180	HT29	viability (Avana library 4 designs)	CTAACATTGAGACTGAACTGAGG	WRN	ENSG00000165392	0.83865645038455	[]	[]	3	hSpCas9	negative selection	3471936
31111618	31111641	8	-	26780180	HT29	viability (Avana library 4 designs)	GTAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	2.9734411935233	[]	[]	8	hSpCas9	negative selection	3471937
31090902	31090925	8	-	26780180	HT29	viability (Avana library 4 designs)	TCTTCCATCAGAGAAATAAGGGG	WRN	ENSG00000165392	0.388020911531485	[]	[]	1	hSpCas9	negative selection	3471938
31090902	31090925	8	-	26780180	A375	viability (Avana lentiCRISPRv2)	TCTTCCATCAGAGAAATAAGGGG	WRN	ENSG00000165392	-9.88364971904869	[]	[]	-7	hSpCas9	negative selection	3578976
31087781	31087804	8	+	26780180	A375	viability (Avana lentiCRISPRv2)	AGAAAACCTCAATAGTGGCACGG	WRN	ENSG00000165392	-7.70068467137729	[]	[]	-7	hSpCas9	negative selection	3578977
31111618	31111641	8	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	5.11835345029177	[]	[]	8	hSpCas9	negative selection	3578978
31080935	31080958	8	+	26780180	A375	viability (Avana lentiCRISPRv2)	CTAACATTGAGACTGAACTGAGG	WRN	ENSG00000165392	0.147807079876795	[]	[]	0	hSpCas9	negative selection	3578979
31076266	31076289	8	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	0.134888964601755	[]	[]	0	hSpCas9	negative selection	3578980
31064415	31064438	8	-	26780180	A375	viability (Avana lentiCRISPRv2)	AACCTGACATGGAAGAAACGTGG	WRN	ENSG00000165392	0.817061322241281	[]	[]	1	hSpCas9	negative selection	3578981
31090902	31090925	8	-	26780180	A375	viability (Avana lentiGuide)	TCTTCCATCAGAGAAATAAGGGG	WRN	ENSG00000165392	0.129419030053798	[]	[]	0	hSpCas9	negative selection	3687635
31087781	31087804	8	+	26780180	A375	viability (Avana lentiGuide)	AGAAAACCTCAATAGTGGCACGG	WRN	ENSG00000165392	-1.07014562106288	[]	[]	-2	hSpCas9	negative selection	3687636
31111618	31111641	8	-	26780180	A375	viability (Avana lentiGuide)	GTAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	1.16186823769793	[]	[]	1	hSpCas9	negative selection	3687637
31080935	31080958	8	+	26780180	A375	viability (Avana lentiGuide)	CTAACATTGAGACTGAACTGAGG	WRN	ENSG00000165392	-2.08692691608639	[]	[]	-4	hSpCas9	negative selection	3687638
31076266	31076289	8	+	26780180	A375	viability (Avana lentiGuide)	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	-5.44799738229118	[]	[]	-8	hSpCas9	negative selection	3687639
31064415	31064438	8	-	26780180	A375	viability (Avana lentiGuide)	AACCTGACATGGAAGAAACGTGG	WRN	ENSG00000165392	-4.1549561310092	[]	[]	-7	hSpCas9	negative selection	3687640
31090902	31090925	8	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCTTCCATCAGAGAAATAAGGGG	WRN	ENSG00000165392	-0.5667095637054722	[8]	[5,4]	-7	hSpCas9	positive selection	3796242
31087781	31087804	8	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGAAAACCTCAATAGTGGCACGG	WRN	ENSG00000165392	-0.6710795208018924	[4]	[3,1]	-7	hSpCas9	positive selection	3796243
31111618	31111641	8	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	0.14562188251971075	[4]	[5,4]	4	hSpCas9	positive selection	3796244
31080935	31080958	8	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTAACATTGAGACTGAACTGAGG	WRN	ENSG00000165392	0.16750123724976726	[5]	[5,5]	4	hSpCas9	positive selection	3796245
31076266	31076289	8	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	0.04439173916968139	[5]	[5,5]	1	hSpCas9	positive selection	3796246
31064415	31064438	8	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AACCTGACATGGAAGAAACGTGG	WRN	ENSG00000165392	0.08344543417601909	[5]	[5,5]	2	hSpCas9	positive selection	3796247
31090902	31090925	8	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCTTCCATCAGAGAAATAAGGGG	WRN	ENSG00000165392	0.16368573057099212	[6]	[6,6]	4	hSpCas9	positive selection	3904849
31087781	31087804	8	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGAAAACCTCAATAGTGGCACGG	WRN	ENSG00000165392	-0.6333149531418434	[4]	[1,2]	-7	hSpCas9	positive selection	3904850
31111618	31111641	8	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	-0.4661963438694183	[4]	[4,0]	-6	hSpCas9	positive selection	3904851
31080935	31080958	8	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTAACATTGAGACTGAACTGAGG	WRN	ENSG00000165392	-0.05304188618322065	[5]	[3,4]	0	hSpCas9	positive selection	3904852
31076266	31076289	8	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	0.2865012153603905	[5]	[6,5]	7	hSpCas9	positive selection	3904853
31064415	31064438	8	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AACCTGACATGGAAGAAACGTGG	WRN	ENSG00000165392	0.06355039389027159	[5]	[4,4]	1	hSpCas9	positive selection	3904854
31059211	31059234	8	-	26780180	A375	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.970174291316832	[]	[]	4	hSpCas9	negative selection	4012928
31059186	31059209	8	+	26780180	A375	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	1.14151145288756	[]	[]	6	hSpCas9	negative selection	4012929
31065042	31065065	8	+	26780180	A375	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.476368603908908	[]	[]	1	hSpCas9	negative selection	4012930
31064972	31064995	8	+	26780180	A375	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	1.44253077433951	[]	[]	8	hSpCas9	negative selection	4012931
31064413	31064436	8	+	26780180	A375	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	1.16931247632339	[]	[]	6	hSpCas9	negative selection	4012932
31064284	31064307	8	+	26780180	A375	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.448398282949355	[]	[]	1	hSpCas9	negative selection	4012933
31059211	31059234	8	-	26780180	HT29	viability (GeCKOv2 library)	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.564352440795582	[]	[]	2	hSpCas9	negative selection	4120894
31059186	31059209	8	+	26780180	HT29	viability (GeCKOv2 library)	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	1.58505554634057	[]	[]	8	hSpCas9	negative selection	4120895
31065042	31065065	8	+	26780180	HT29	viability (GeCKOv2 library)	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	-0.0510487324953691	[]	[]	-1	hSpCas9	negative selection	4120896
31064972	31064995	8	+	26780180	HT29	viability (GeCKOv2 library)	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.937008047541838	[]	[]	4	hSpCas9	negative selection	4120897
31064413	31064436	8	+	26780180	HT29	viability (GeCKOv2 library)	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.933849709488551	[]	[]	4	hSpCas9	negative selection	4120898
31064284	31064307	8	+	26780180	HT29	viability (GeCKOv2 library)	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.363932686734144	[]	[]	1	hSpCas9	negative selection	4120899
31059211	31059234	8	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.5832383748301846	[2]	[0,0]	-9	hSpCas9	positive selection	4182706
31059248	31059271	8	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTTACCTAATATCTTCTGACAGG	WRN	ENSG00000165392	0.05098260817565231	[2]	[1,1]	1	hSpCas9	positive selection	4182707
31064413	31064436	8	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.004949515039247371	[4]	[3,1]	0	hSpCas9	positive selection	4182708
31059211	31059234	8	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.2247408554263364	[3]	[3,3,1,0]	1	hSpCas9	positive selection	4246728
31059248	31059271	8	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTTACCTAATATCTTCTGACAGG	WRN	ENSG00000165392	-0.1288344622829626	[3]	[1,3,0,0]	-2	hSpCas9	positive selection	4246729
31064413	31064436	8	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.9225162660008666	[4]	[2,0,4,3]	6	hSpCas9	positive selection	4246730
31064284	31064307	8	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.28492871096750494	[3]	[4,3]	6	hSpCas9	positive selection	4308026
31064413	31064436	8	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.2921955263786981	[3]	[3,3]	6	hSpCas9	positive selection	4308027
31059186	31059209	8	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	-0.4741467826304825	[1]	[0,0]	-8	hSpCas9	positive selection	4308028
31059211	31059234	8	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.3941948209677667	[3]	[3,3]	7	hSpCas9	positive selection	4372274
31064972	31064995	8	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.6399197656214564	[2]	[2,0]	-9	hSpCas9	positive selection	4372275
31065042	31065065	8	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.27457591136170806	[3]	[3,2]	5	hSpCas9	positive selection	4372276
31096777	31096799	8	-	27760321	OCIAML3	viability	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	-4.596690808831225	[32,28]	[0,0]	-9	hSpCas9	negative selection	4454405
31111618	31111640	8	-	27760321	OCIAML3	viability	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	0.559696834439419	[213,175]	[244,195]	6	hSpCas9	negative selection	4454406
31064286	31064308	8	+	27760321	OCIAML3	viability	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	0.33506097890694675	[146,110]	[130,119]	4	hSpCas9	negative selection	4454407
31067107	31067129	8	+	27760321	OCIAML3	viability	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	0.6497706434720604	[555,490]	[648,630]	7	hSpCas9	negative selection	4454408
31067169	31067191	8	-	27760321	OCIAML3	viability	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.0635071964641522	[436,367]	[371,269]	0	hSpCas9	negative selection	4454409
31096777	31096799	8	-	27760321	OCIAML2	viability	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	-1.6779767021702097	[32,28]	[12,0]	-8	hSpCas9	negative selection	4537868
31111618	31111640	8	-	27760321	OCIAML2	viability	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	-0.06887600657389714	[213,175]	[153,143]	-1	hSpCas9	negative selection	4537869
31064286	31064308	8	+	27760321	OCIAML2	viability	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	-0.05898995589248579	[146,110]	[88,112]	-1	hSpCas9	negative selection	4537870
31067107	31067129	8	+	27760321	OCIAML2	viability	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	0.23523700480019	[555,490]	[390,637]	3	hSpCas9	negative selection	4537871
31067169	31067191	8	-	27760321	OCIAML2	viability	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.8486878548341164	[436,367]	[641,507]	9	hSpCas9	negative selection	4537872
31096777	31096799	8	-	27760321	MV411	viability	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	-3.866527243109443	[32,28]	[0,1]	-9	hSpCas9	negative selection	4621331
31111618	31111640	8	-	27760321	MV411	viability	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	-0.46809577456172313	[213,175]	[76,115]	-3	hSpCas9	negative selection	4621332
31064286	31064308	8	+	27760321	MV411	viability	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	0.9877966222765374	[146,110]	[216,92]	7	hSpCas9	negative selection	4621333
31067107	31067129	8	+	27760321	MV411	viability	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	0.060859317693468695	[555,490]	[226,558]	0	hSpCas9	negative selection	4621334
31067169	31067191	8	-	27760321	MV411	viability	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	1.9764178686064997	[436,367]	[1394,509]	9	hSpCas9	negative selection	4621335
31096777	31096799	8	-	27760321	HL60	viability	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	-2.1101689625266755	[32,28]	[0,10]	-9	hSpCas9	negative selection	4704794
31111618	31111640	8	-	27760321	HL60	viability	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	-0.16027596431483637	[213,175]	[120,163]	-2	hSpCas9	negative selection	4704795
31064286	31064308	8	+	27760321	HL60	viability	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	-0.5320523802180595	[146,110]	[64,79]	-5	hSpCas9	negative selection	4704796
31067107	31067129	8	+	27760321	HL60	viability	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	0.8578904697175725	[555,490]	[744,803]	8	hSpCas9	negative selection	4704797
31067169	31067191	8	-	27760321	HL60	viability	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.14881087513340907	[436,367]	[334,392]	1	hSpCas9	negative selection	4704798
31096777	31096799	8	-	27760321	HT1080	viability	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	4.015234243713913	[28,22]	[96,244]	9	hSpCas9	negative selection	4788257
31111618	31111640	8	-	27760321	HT1080	viability	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	-0.7629363789243537	[175,137]	[12,62]	-3	hSpCas9	negative selection	4788258
31064286	31064308	8	+	27760321	HT1080	viability	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	-5.301918691491073	[110,86]	[0,0]	-8	hSpCas9	negative selection	4788259
31067107	31067129	8	+	27760321	HT1080	viability	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	-2.0852140425208288	[490,382]	[30,51]	-6	hSpCas9	negative selection	4788260
31067169	31067191	8	-	27760321	HT1080	viability	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	-0.7047238274268443	[367,286]	[80,78]	-3	hSpCas9	negative selection	4788261
31096777	31096799	8	-	27760321	HT29	viability after 7 days	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	-0.6895294718010638	[28,22]	[28,32,1]	-7	hSpCas9	negative selection	4871720
31111618	31111640	8	-	27760321	HT29	viability after 7 days	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	0.10203016558206279	[175,137]	[74,222,327]	1	hSpCas9	negative selection	4871721
31064286	31064308	8	+	27760321	HT29	viability after 7 days	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	-0.04303261474490827	[110,86]	[204,111,66]	0	hSpCas9	negative selection	4871722
31067107	31067129	8	+	27760321	HT29	viability after 7 days	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	-0.12442949158625788	[490,382]	[599,392,562]	-2	hSpCas9	negative selection	4871723
31067169	31067191	8	-	27760321	HT29	viability after 7 days	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.39241080412777707	[367,286]	[423,507,701]	6	hSpCas9	negative selection	4871724
31096777	31096799	8	-	27760321	HT29	viability after 25 days	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	-1.7061590858574314	[28,22]	[0,24,0]	-7	hSpCas9	negative selection	4955183
31111618	31111640	8	-	27760321	HT29	viability after 25 days	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	0.041424255189800085	[175,137]	[121,162,282]	0	hSpCas9	negative selection	4955184
31064286	31064308	8	+	27760321	HT29	viability after 25 days	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	0.8135295737862185	[110,86]	[216,146,234]	8	hSpCas9	negative selection	4955185
31067107	31067129	8	+	27760321	HT29	viability after 25 days	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	0.06478085401822509	[490,382]	[660,472,411]	0	hSpCas9	negative selection	4955186
31067169	31067191	8	-	27760321	HT29	viability after 25 days	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.6515847487623947	[367,286]	[387,544,871]	7	hSpCas9	negative selection	4955187
31096777	31096799	8	-	27760321	HT29	viability after 22 days	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	-0.7753024079951332	[28,22]	[1,49,0]	-6	hSpCas9	negative selection	5038646
31111618	31111640	8	-	27760321	HT29	viability after 22 days	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	0.24310483743384637	[175,137]	[81,267,298]	2	hSpCas9	negative selection	5038647
31064286	31064308	8	+	27760321	HT29	viability after 22 days	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	0.8923369044904214	[110,86]	[243,244,146]	8	hSpCas9	negative selection	5038648
31067107	31067129	8	+	27760321	HT29	viability after 22 days	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	0.24960802547397148	[490,382]	[664,536,597]	2	hSpCas9	negative selection	5038649
31067169	31067191	8	-	27760321	HT29	viability after 22 days	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.09336226883106774	[367,286]	[180,601,434]	0	hSpCas9	negative selection	5038650
31096777	31096799	8	-	27760321	HT29	viability after 19 days	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	-2.9973680048886755	[28,22]	[0,8,0]	-8	hSpCas9	negative selection	5122109
31111618	31111640	8	-	27760321	HT29	viability after 19 days	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	0.7948104311000801	[175,137]	[166,187,554]	7	hSpCas9	negative selection	5122110
31064286	31064308	8	+	27760321	HT29	viability after 19 days	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	0.017659903606734417	[110,86]	[142,173,32]	0	hSpCas9	negative selection	5122111
31067107	31067129	8	+	27760321	HT29	viability after 19 days	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	-0.005102206664542641	[490,382]	[260,632,571]	0	hSpCas9	negative selection	5122112
31067169	31067191	8	-	27760321	HT29	viability after 19 days	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.726064957888795	[367,286]	[618,696,544]	7	hSpCas9	negative selection	5122113
31096777	31096799	8	-	27760321	HT29	viability after 16 days	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	-0.029997544313154823	[28,22]	[7,51,22]	0	hSpCas9	negative selection	5205572
31111618	31111640	8	-	27760321	HT29	viability after 16 days	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	-0.023739871068024332	[175,137]	[269,197,58]	0	hSpCas9	negative selection	5205573
31064286	31064308	8	+	27760321	HT29	viability after 16 days	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	0.9822447493081843	[110,86]	[163,233,252]	9	hSpCas9	negative selection	5205574
31067107	31067129	8	+	27760321	HT29	viability after 16 days	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	0.05780432338290509	[490,382]	[581,450,501]	0	hSpCas9	negative selection	5205575
31067169	31067191	8	-	27760321	HT29	viability after 16 days	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.6030553467509896	[367,286]	[254,632,750]	7	hSpCas9	negative selection	5205576
31096777	31096799	8	-	27760321	HT29	viability after 13 days	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	-1.497616585299634	[28,22]	[7,11,11]	-8	hSpCas9	negative selection	5289035
31111618	31111640	8	-	27760321	HT29	viability after 13 days	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	0.3521461176351496	[175,137]	[87,377,231]	4	hSpCas9	negative selection	5289036
31064286	31064308	8	+	27760321	HT29	viability after 13 days	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	0.7866597063999612	[110,86]	[101,179,305]	9	hSpCas9	negative selection	5289037
31067107	31067129	8	+	27760321	HT29	viability after 13 days	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	0.023869608638340534	[490,382]	[456,807,294]	0	hSpCas9	negative selection	5289038
31067169	31067191	8	-	27760321	HT29	viability after 13 days	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.9891183120075188	[367,286]	[659,1010,600]	9	hSpCas9	negative selection	5289039
31096777	31096799	8	-	27760321	HT29	viability after 10 days	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	-1.9359356398436014	[28,22]	[3,20,0]	-9	hSpCas9	negative selection	5372498
31111618	31111640	8	-	27760321	HT29	viability after 10 days	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	-0.09650400770166256	[175,137]	[152,173,221]	-1	hSpCas9	negative selection	5372499
31064286	31064308	8	+	27760321	HT29	viability after 10 days	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	0.8541325845814318	[110,86]	[187,169,308]	9	hSpCas9	negative selection	5372500
31067107	31067129	8	+	27760321	HT29	viability after 10 days	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	-0.1983951565985577	[490,382]	[459,513,453]	-3	hSpCas9	negative selection	5372501
31067169	31067191	8	-	27760321	HT29	viability after 10 days	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.4268348626841634	[367,286]	[328,670,649]	6	hSpCas9	negative selection	5372502
31096777	31096799	8	-	27760321	MOLM13	viability	TGGAGTTACGTATACAATCCGG	WRN	ENSG00000165392	1.6419908899204159	[32,28]	[0,99]	9	hSpCas9	negative selection	5455961
31111618	31111640	8	-	27760321	MOLM13	viability	TAGCAGTAAGTGCAACGATTGG	WRN	ENSG00000165392	0.4328345132946321	[213,175]	[109,179]	3	hSpCas9	negative selection	5455962
31064286	31064308	8	+	27760321	MOLM13	viability	TAGCATGAGTCTATCAGATGGG	WRN	ENSG00000165392	1.845543258449435	[146,110]	[562,0]	9	hSpCas9	negative selection	5455963
31067107	31067129	8	+	27760321	MOLM13	viability	GTCTATCCGCTGTAGCAATTGG	WRN	ENSG00000165392	-0.34332960632428805	[555,490]	[85,356]	-2	hSpCas9	negative selection	5455964
31067169	31067191	8	-	27760321	MOLM13	viability	GCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.22415546827115812	[436,367]	[179,335]	1	hSpCas9	negative selection	5455965
31033780	31033803	8	+	27661255	K562	viability	GGCGGGTCGGGTAGGTCTCCCGG	WRN	ENSG00000165392	-0.09908708199684468	[625,671]	[565,412]	-4	dCas9-KRAB	negative selection	5523046
31033827	31033850	8	+	27661255	K562	viability	GGGAGGCGCCGGCTTGTACTCGG	WRN	ENSG00000165392	-0.12001437382136249	[1473,1504]	[1304,914]	-4	dCas9-KRAB	negative selection	5523047
31034291	31034314	8	+	27661255	K562	viability	GGTCTGCACAGCAAAGTCGAGGG	WRN	ENSG00000165392	0.19079148963709702	[974,1290]	[1016,1036]	6	dCas9-KRAB	negative selection	5523048
31033907	31033930	8	-	27661255	K562	viability	GTGGAGCGCCACCACAAGCAGGG	WRN	ENSG00000165392	0.1056305289616064	[178,353]	[214,235]	3	dCas9-KRAB	negative selection	5523049
31034205	31034228	8	-	27661255	K562	viability	GCAAGGTAAACATCAAGCTGGGG	WRN	ENSG00000165392	0.211297724392988	[338,335]	[363,267]	7	dCas9-KRAB	negative selection	5523050
31064284	31064307	8	+	27260156	BXPC3	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.17531247890427382	[933]	[1009,963,1233,1231]	4	hSpCas9	negative selection	5580486
31064413	31064436	8	+	27260156	BXPC3	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.31415899230643396	[657]	[800,798,853,986]	6	hSpCas9	negative selection	5580487
31059186	31059209	8	+	27260156	BXPC3	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.34056392372050914	[149]	[153,186,182,284]	7	hSpCas9	negative selection	5580488
31059211	31059234	8	-	27260156	BXPC3	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.016065446031594433	[689]	[528,864,683,790]	0	hSpCas9	negative selection	5644734
31064972	31064995	8	+	27260156	BXPC3	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.22257507578965285	[383]	[447,485,458,479]	5	hSpCas9	negative selection	5644735
31065042	31065065	8	+	27260156	BXPC3	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.27611418496106355	[460]	[592,566,475,707]	6	hSpCas9	negative selection	5644736
31064284	31064307	8	+	27260156	A673	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.06148596275304585	[933]	[1244,914,1148,1006]	-1	hSpCas9	negative selection	5701737
31064413	31064436	8	+	27260156	A673	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.20927654385487116	[657]	[991,852,824,997]	5	hSpCas9	negative selection	5701738
31059186	31059209	8	+	27260156	A673	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.3304629606100058	[149]	[317,189,187,220]	7	hSpCas9	negative selection	5701739
31059211	31059234	8	-	27260156	A673	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.04765269918421111	[689]	[858,802,686,866]	-1	hSpCas9	negative selection	5765985
31064972	31064995	8	+	27260156	A673	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.06158509551161542	[383]	[541,414,514,458]	1	hSpCas9	negative selection	5765986
31065042	31065065	8	+	27260156	A673	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.17767204574056975	[460]	[768,604,594,546]	4	hSpCas9	negative selection	5765987
31064284	31064307	8	+	27260156	A375	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.06722961516398185	[933]	[938,1664,1164,898]	1	hSpCas9	negative selection	5822988
31064413	31064436	8	+	27260156	A375	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.6257044177520595	[657]	[1434,1427,1074,873]	8	hSpCas9	negative selection	5822989
31059186	31059209	8	+	27260156	A375	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.6444963385620524	[149]	[356,308,160,272]	8	hSpCas9	negative selection	5822990
31059211	31059234	8	-	27260156	A375	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.22932890987478327	[689]	[1092,876,925,878]	3	hSpCas9	negative selection	5887236
31064972	31064995	8	+	27260156	A375	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.2704609864931162	[383]	[642,616,610,327]	4	hSpCas9	negative selection	5887237
31065042	31065065	8	+	27260156	A375	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.7180562067064042	[460]	[941,1243,742,684]	9	hSpCas9	negative selection	5887238
31064284	31064307	8	+	27260156	COLO741	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.0034788341937691536	[933]	[1545,1150,921]	0	hSpCas9	negative selection	5944239
31064413	31064436	8	+	27260156	COLO741	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.440277154692414	[657]	[1356,1042,1044]	8	hSpCas9	negative selection	5944240
31059186	31059209	8	+	27260156	COLO741	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.49867963788058955	[149]	[347,224,246]	8	hSpCas9	negative selection	5944241
31059211	31059234	8	-	27260156	COLO741	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.01873520020950248	[689]	[904,818,949]	0	hSpCas9	negative selection	6008487
31064972	31064995	8	+	27260156	COLO741	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.004693525486251682	[383]	[545,480,446]	0	hSpCas9	negative selection	6008488
31065042	31065065	8	+	27260156	COLO741	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.20427707921458668	[460]	[715,622,696]	4	hSpCas9	negative selection	6008489
31064284	31064307	8	+	27260156	CAL120	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.021049094371168198	[933]	[1346,1161,1055]	0	hSpCas9	negative selection	6065490
31064413	31064436	8	+	27260156	CAL120	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.7846224751227288	[657]	[1651,1300,1315]	9	hSpCas9	negative selection	6065491
31059186	31059209	8	+	27260156	CAL120	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.67497146947911	[149]	[526,82,317]	8	hSpCas9	negative selection	6065492
31059211	31059234	8	-	27260156	CAL120	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.42769927692635046	[689]	[1567,889,1069]	6	hSpCas9	negative selection	6129738
31064972	31064995	8	+	27260156	CAL120	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.0975448983094673	[383]	[898,352,342]	1	hSpCas9	negative selection	6129739
31065042	31065065	8	+	27260156	CAL120	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.5334281788123908	[460]	[1281,752,528]	7	hSpCas9	negative selection	6129740
31064284	31064307	8	+	27260156	CADOES1	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.17879201304386916	[933]	[705,771,845,744]	-3	hSpCas9	negative selection	6186741
31064413	31064436	8	+	27260156	CADOES1	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.4847370808950692	[657]	[931,596,877,1023]	7	hSpCas9	negative selection	6186742
31059186	31059209	8	+	27260156	CADOES1	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.2557958387994548	[149]	[184,216,157,103]	4	hSpCas9	negative selection	6186743
31059211	31059234	8	-	27260156	CADOES1	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.03836821272904967	[689]	[704,843,643,434]	0	hSpCas9	negative selection	6250989
31064972	31064995	8	+	27260156	CADOES1	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.1775173975420099	[383]	[381,286,276,316]	-3	hSpCas9	negative selection	6250990
31065042	31065065	8	+	27260156	CADOES1	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.053045133640965865	[460]	[393,424,472,488]	0	hSpCas9	negative selection	6250991
31064284	31064307	8	+	27260156	EWS502	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.06536831145528543	[933]	[771,961,975,1099]	-1	hSpCas9	negative selection	6307992
31064413	31064436	8	+	27260156	EWS502	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.6048729590185423	[657]	[1044,1148,1085,945]	9	hSpCas9	negative selection	6307993
31059186	31059209	8	+	27260156	EWS502	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.5390092497715064	[149]	[248,202,246,221]	8	hSpCas9	negative selection	6307994
31059211	31059234	8	-	27260156	EWS502	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.03504183393538851	[689]	[635,767,735,873]	0	hSpCas9	negative selection	6372240
31064972	31064995	8	+	27260156	EWS502	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.3508375527166637	[383]	[533,635,473,413]	6	hSpCas9	negative selection	6372241
31065042	31065065	8	+	27260156	EWS502	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.5609406144346956	[460]	[628,695,707,867]	8	hSpCas9	negative selection	6372242
31064284	31064307	8	+	27260156	EW8	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.016601352893226173	[933]	[748,940,630,690]	0	hSpCas9	negative selection	6429243
31064413	31064436	8	+	27260156	EW8	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.32019813326745494	[657]	[782,731,550,627]	6	hSpCas9	negative selection	6429244
31059186	31059209	8	+	27260156	EW8	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.7000376810402372	[149]	[273,165,231,119]	9	hSpCas9	negative selection	6429245
31059211	31059234	8	-	27260156	EW8	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.7200979099499142	[689]	[443,375,290,265]	-8	hSpCas9	negative selection	6493491
31064972	31064995	8	+	27260156	EW8	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.09496957311329213	[383]	[315,163,299,384]	-2	hSpCas9	negative selection	6493492
31065042	31065065	8	+	27260156	EW8	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.1405331132478277	[460]	[551,446,328,347]	2	hSpCas9	negative selection	6493493
31064284	31064307	8	+	27260156	CORL105	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.0858488563018045	[933]	[945,1119,1048,1003]	-1	hSpCas9	negative selection	6550494
31064413	31064436	8	+	27260156	CORL105	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.3518347284317118	[657]	[1036,962,1043,899]	6	hSpCas9	negative selection	6550495
31059186	31059209	8	+	27260156	CORL105	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.4437172422700504	[149]	[232,180,332,223]	7	hSpCas9	negative selection	6550496
31059211	31059234	8	-	27260156	CORL105	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.08689080362337198	[689]	[772,742,1064,881]	1	hSpCas9	negative selection	6614742
31064972	31064995	8	+	27260156	CORL105	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.045299777077583425	[383]	[323,504,467,552]	0	hSpCas9	negative selection	6614743
31065042	31065065	8	+	27260156	CORL105	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.3787818664946001	[460]	[583,762,756,705]	7	hSpCas9	negative selection	6614744
31064284	31064307	8	+	27260156	HS294T	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.11193313406681038	[933]	[364,247,385,336]	-1	hSpCas9	negative selection	6671745
31064413	31064436	8	+	27260156	HS294T	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.20555675774341997	[657]	[286,309,259,319]	2	hSpCas9	negative selection	6671746
31059186	31059209	8	+	27260156	HS294T	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.23996960877821616	[149]	[56,95,61,56]	3	hSpCas9	negative selection	6671747
31059211	31059234	8	-	27260156	HS294T	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.024935671573238394	[689]	[241,259,250,303]	0	hSpCas9	negative selection	6735993
31064972	31064995	8	+	27260156	HS294T	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.6640794882570642	[383]	[71,102,78,127]	-7	hSpCas9	negative selection	6735994
31065042	31065065	8	+	27260156	HS294T	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.34940859771859023	[460]	[240,170,159,357]	5	hSpCas9	negative selection	6735995
31064284	31064307	8	+	27260156	HCC44	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.017206693948267904	[933]	[1062,1123,1054,920]	0	hSpCas9	negative selection	6792996
31064413	31064436	8	+	27260156	HCC44	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.3318450982630625	[657]	[1059,747,1011,968]	5	hSpCas9	negative selection	6792997
31059186	31059209	8	+	27260156	HCC44	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.38545418725933667	[149]	[163,306,132,246]	6	hSpCas9	negative selection	6792998
31059211	31059234	8	-	27260156	HCC44	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.19102404266286943	[689]	[600,381,1195,673]	-3	hSpCas9	negative selection	6857244
31064972	31064995	8	+	27260156	HCC44	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.05027307578738838	[383]	[553,365,382,385]	-1	hSpCas9	negative selection	6857245
31065042	31065065	8	+	27260156	HCC44	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.19704785878751901	[460]	[542,352,1077,526]	3	hSpCas9	negative selection	6857246
31064284	31064307	8	+	27260156	G402	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.49839624373213787	[933]	[606,873,720,987]	-6	hSpCas9	negative selection	6914247
31064413	31064436	8	+	27260156	G402	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.47242915962773624	[657]	[1844,973,1103,648]	6	hSpCas9	negative selection	6914248
31059186	31059209	8	+	27260156	G402	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.8632472970905272	[149]	[500,172,327,342]	9	hSpCas9	negative selection	6914249
31059211	31059234	8	-	27260156	G402	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.624256063955424	[689]	[530,390,734,515]	-6	hSpCas9	negative selection	6978495
31064972	31064995	8	+	27260156	G402	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-1.243974084669007	[383]	[139,258,278,111]	-8	hSpCas9	negative selection	6978496
31065042	31065065	8	+	27260156	G402	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.8813989489219204	[460]	[1486,1034,669,1014]	9	hSpCas9	negative selection	6978497
31064284	31064307	8	+	27260156	L33	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.03341196455558926	[933]	[859,341,639,938]	0	hSpCas9	negative selection	7035498
31064413	31064436	8	+	27260156	L33	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.08709170328987936	[657]	[804,281,435,606]	2	hSpCas9	negative selection	7035499
31059186	31059209	8	+	27260156	L33	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.6292496280025455	[149]	[128,118,144,279]	9	hSpCas9	negative selection	7035500
31059211	31059234	8	-	27260156	L33	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.025592938888274852	[689]	[739,273,467,557]	0	hSpCas9	negative selection	7099746
31064972	31064995	8	+	27260156	L33	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.2392162775266297	[383]	[334,238,244,506]	5	hSpCas9	negative selection	7099747
31065042	31065065	8	+	27260156	L33	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.18697957150475344	[460]	[568,191,377,459]	4	hSpCas9	negative selection	7099748
31064284	31064307	8	+	27260156	K562	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.18951072299569816	[933]	[888,919,1281,707]	2	hSpCas9	negative selection	7156749
31064413	31064436	8	+	27260156	K562	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.6645965853943464	[657]	[863,1111,997,749]	8	hSpCas9	negative selection	7156750
31059186	31059209	8	+	27260156	K562	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.9936561890232987	[149]	[559,69,92,340]	9	hSpCas9	negative selection	7156751
31059211	31059234	8	-	27260156	K562	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.029195207440067206	[689]	[784,514,625,582]	0	hSpCas9	negative selection	7220997
31064972	31064995	8	+	27260156	K562	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.4174044211651443	[383]	[326,258,319,133]	-5	hSpCas9	negative selection	7220998
31065042	31065065	8	+	27260156	K562	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.4804959915059014	[460]	[490,664,418,689]	6	hSpCas9	negative selection	7220999
31064284	31064307	8	+	27260156	HT29	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.1774534336129986	[933]	[1186,1503,1207,1243]	3	hSpCas9	negative selection	7278000
31064413	31064436	8	+	27260156	HT29	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.43720508804089653	[657]	[1078,1114,909,1206]	8	hSpCas9	negative selection	7278001
31059186	31059209	8	+	27260156	HT29	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.5268661881294532	[149]	[268,226,382,177]	8	hSpCas9	negative selection	7278002
31059211	31059234	8	-	27260156	HT29	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.09777718159153992	[689]	[1087,822,845,841]	1	hSpCas9	negative selection	7342248
31064972	31064995	8	+	27260156	HT29	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.23485766212857212	[383]	[536,780,396,502]	4	hSpCas9	negative selection	7342249
31065042	31065065	8	+	27260156	HT29	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.4517652114269285	[460]	[800,763,742,755]	8	hSpCas9	negative selection	7342250
31064284	31064307	8	+	27260156	MHHES1	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.16398360552874502	[933]	[1085,1331,1126,1151]	3	hSpCas9	negative selection	7399251
31064413	31064436	8	+	27260156	MHHES1	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.5158031566679496	[657]	[1074,1061,1122,975]	8	hSpCas9	negative selection	7399252
31059186	31059209	8	+	27260156	MHHES1	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.2436583512947268	[149]	[150,238,190,209]	4	hSpCas9	negative selection	7399253
31059211	31059234	8	-	27260156	MHHES1	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.33215714464853296	[689]	[870,1035,1243,780]	6	hSpCas9	negative selection	7463499
31064972	31064995	8	+	27260156	MHHES1	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.22296531068908482	[383]	[654,479,568,354]	4	hSpCas9	negative selection	7463500
31065042	31065065	8	+	27260156	MHHES1	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.33597407359597886	[460]	[936,795,577,402]	6	hSpCas9	negative selection	7463501
31064284	31064307	8	+	27260156	MEWO	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.020062456083844826	[933]	[1100,803,794]	0	hSpCas9	negative selection	7520502
31064413	31064436	8	+	27260156	MEWO	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.33652575537739027	[657]	[966,684,716]	7	hSpCas9	negative selection	7520503
31059186	31059209	8	+	27260156	MEWO	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.6218315642788732	[149]	[266,152,237]	9	hSpCas9	negative selection	7520504
31059211	31059234	8	-	27260156	MEWO	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.16388040902656353	[689]	[708,628,415]	-4	hSpCas9	negative selection	7584750
31064972	31064995	8	+	27260156	MEWO	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.29198633001958635	[383]	[580,395,369]	6	hSpCas9	negative selection	7584751
31065042	31065065	8	+	27260156	MEWO	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.08752800496177787	[460]	[524,383,478]	2	hSpCas9	negative selection	7584752
31064284	31064307	8	+	27260156	LNCAPCLONEFGC	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.07999671612314208	[933]	[789,931,869,610]	-1	hSpCas9	negative selection	7641753
31064413	31064436	8	+	27260156	LNCAPCLONEFGC	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.47064740329269317	[657]	[777,802,867,862]	7	hSpCas9	negative selection	7641754
31059186	31059209	8	+	27260156	LNCAPCLONEFGC	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.9036354513445801	[149]	[365,205,222,217]	9	hSpCas9	negative selection	7641755
31059211	31059234	8	-	27260156	LNCAPCLONEFGC	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.26894684499561533	[689]	[566,595,413,475]	-4	hSpCas9	negative selection	7706001
31064972	31064995	8	+	27260156	LNCAPCLONEFGC	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.06802785132011435	[383]	[370,281,448,244]	-1	hSpCas9	negative selection	7706002
31065042	31065065	8	+	27260156	LNCAPCLONEFGC	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.6976129545657691	[460]	[485,709,729,791]	9	hSpCas9	negative selection	7706003
31064284	31064307	8	+	27260156	PANC0327	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.2818735107332272	[933]	[1039,920,1285,801]	4	hSpCas9	negative selection	7763004
31064413	31064436	8	+	27260156	PANC0327	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.24907704913536732	[657]	[729,563,652,850]	3	hSpCas9	negative selection	7763005
31059186	31059209	8	+	27260156	PANC0327	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	-0.10666225536386609	[149]	[95,174,83,130]	-1	hSpCas9	negative selection	7763006
31059211	31059234	8	-	27260156	PANC0327	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.3514983110511879	[689]	[424,463,490,538]	-5	hSpCas9	negative selection	7827252
31064972	31064995	8	+	27260156	PANC0327	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.22173589185989173	[383]	[239,376,383,153]	-3	hSpCas9	negative selection	7827253
31065042	31065065	8	+	27260156	PANC0327	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.7007122753527882	[460]	[696,388,576,1036]	8	hSpCas9	negative selection	7827254
31064284	31064307	8	+	27260156	NCIH2009	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.25676770357308365	[933]	[1953,1439,1360]	3	hSpCas9	negative selection	7884255
31064413	31064436	8	+	27260156	NCIH2009	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.05114765903838858	[657]	[1019,1020,826]	0	hSpCas9	negative selection	7884256
31059186	31059209	8	+	27260156	NCIH2009	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.5089312864254121	[149]	[402,235,276]	7	hSpCas9	negative selection	7884257
31059211	31059234	8	-	27260156	NCIH2009	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.02812645030524885	[689]	[1197,865,927]	0	hSpCas9	negative selection	7948503
31064972	31064995	8	+	27260156	NCIH2009	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.35402930410812233	[383]	[863,478,751]	5	hSpCas9	negative selection	7948504
31065042	31065065	8	+	27260156	NCIH2009	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.5484777493036088	[460]	[1199,964,709]	7	hSpCas9	negative selection	7948505
31064284	31064307	8	+	27260156	NCIH1373	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.6060067915368798	[933]	[2231,1380,1013,496]	6	hSpCas9	negative selection	8005506
31064413	31064436	8	+	27260156	NCIH1373	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	1.0687839223094047	[657]	[1702,1117,1576,491]	9	hSpCas9	negative selection	8005507
31059186	31059209	8	+	27260156	NCIH1373	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	1.3348592354688493	[149]	[627,476,207,107]	9	hSpCas9	negative selection	8005508
31059211	31059234	8	-	27260156	NCIH1373	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.7635927634428875	[689]	[2593,810,1044,272]	7	hSpCas9	negative selection	8069754
31064972	31064995	8	+	27260156	NCIH1373	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.588043474541248	[383]	[935,470,357,237]	6	hSpCas9	negative selection	8069755
31065042	31065065	8	+	27260156	NCIH1373	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.7439522057644768	[460]	[1115,754,613,272]	7	hSpCas9	negative selection	8069756
31064284	31064307	8	+	27260156	PATU8902	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.5286743265747776	[933]	[1438,1742,1420,3165]	5	hSpCas9	negative selection	8126757
31064413	31064436	8	+	27260156	PATU8902	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.7955322842064539	[657]	[1727,2064,1268,1340]	8	hSpCas9	negative selection	8126758
31059186	31059209	8	+	27260156	PATU8902	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	1.148771569210386	[149]	[358,423,287,873]	9	hSpCas9	negative selection	8126759
31059211	31059234	8	-	27260156	PATU8902	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.045107286552761305	[689]	[1184,1012,740,810]	0	hSpCas9	negative selection	8191005
31064972	31064995	8	+	27260156	PATU8902	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.13602616536893025	[383]	[832,727,368,453]	1	hSpCas9	negative selection	8191006
31065042	31065065	8	+	27260156	PATU8902	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.7423860938882441	[460]	[1086,1023,1208,912]	7	hSpCas9	negative selection	8191007
31064284	31064307	8	+	27260156	PANC1	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.13966352645114044	[933]	[839,1379,806,636]	2	hSpCas9	negative selection	8248008
31064413	31064436	8	+	27260156	PANC1	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.4131964336708609	[657]	[781,926,580,742]	6	hSpCas9	negative selection	8248009
31059186	31059209	8	+	27260156	PANC1	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.5955258031948518	[149]	[254,265,106,164]	8	hSpCas9	negative selection	8248010
31059211	31059234	8	-	27260156	PANC1	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.04674684938827178	[689]	[408,1263,499,432]	0	hSpCas9	negative selection	8312256
31064972	31064995	8	+	27260156	PANC1	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.03851342758834375	[383]	[389,363,433,190]	0	hSpCas9	negative selection	8312257
31065042	31065065	8	+	27260156	PANC1	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.6425245346224442	[460]	[598,708,814,396]	9	hSpCas9	negative selection	8312258
31064284	31064307	8	+	27260156	PANC0813	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.43820944055523736	[933]	[896,783,936,637]	-6	hSpCas9	negative selection	8369259
31064413	31064436	8	+	27260156	PANC0813	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.05558750751012187	[657]	[825,945,620,818]	0	hSpCas9	negative selection	8369260
31059186	31059209	8	+	27260156	PANC0813	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.6901651546284786	[149]	[296,341,308,194]	9	hSpCas9	negative selection	8369261
31059211	31059234	8	-	27260156	PANC0813	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.6713979452566795	[689]	[582,420,394,634]	-7	hSpCas9	negative selection	8433507
31064972	31064995	8	+	27260156	PANC0813	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.6216447467315381	[383]	[335,294,321,226]	-7	hSpCas9	negative selection	8433508
31065042	31065065	8	+	27260156	PANC0813	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.1274658214787942	[460]	[548,782,533,499]	2	hSpCas9	negative selection	8433509
31064284	31064307	8	+	27260156	RDES	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.17462535589375072	[933]	[771,844,935,1331]	-3	hSpCas9	negative selection	8490510
31064413	31064436	8	+	27260156	RDES	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.47339455516726525	[657]	[818,1047,1181,1199]	7	hSpCas9	negative selection	8490511
31059186	31059209	8	+	27260156	RDES	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.7091371188615715	[149]	[238,197,221,510]	9	hSpCas9	negative selection	8490512
31059211	31059234	8	-	27260156	RDES	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.1255602487586489	[689]	[654,785,1030,1053]	2	hSpCas9	negative selection	8554758
31064972	31064995	8	+	27260156	RDES	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.18608281786879238	[383]	[335,267,506,469]	-3	hSpCas9	negative selection	8554759
31065042	31065065	8	+	27260156	RDES	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.531743874754367	[460]	[638,627,883,967]	8	hSpCas9	negative selection	8554760
31064284	31064307	8	+	27260156	PC3	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.04711693030413078	[933]	[614,1036,1463,720]	-1	hSpCas9	negative selection	8611761
31064413	31064436	8	+	27260156	PC3	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.23242335623923793	[657]	[450,862,1340,709]	5	hSpCas9	negative selection	8611762
31059186	31059209	8	+	27260156	PC3	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.26261643522791145	[149]	[109,145,401,160]	6	hSpCas9	negative selection	8611763
31059211	31059234	8	-	27260156	PC3	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.11880781022977172	[689]	[433,420,1338,649]	-3	hSpCas9	negative selection	8676009
31064972	31064995	8	+	27260156	PC3	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.013094202295676316	[383]	[218,323,585,513]	0	hSpCas9	negative selection	8676010
31065042	31065065	8	+	27260156	PC3	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.31581647849068184	[460]	[326,635,721,718]	6	hSpCas9	negative selection	8676011
31064284	31064307	8	+	27260156	PATU8988T	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.15392286367505237	[933]	[1079,942,992,993]	2	hSpCas9	negative selection	8733012
31064413	31064436	8	+	27260156	PATU8988T	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.29816863233226465	[657]	[653,644,1027,783]	5	hSpCas9	negative selection	8733013
31059186	31059209	8	+	27260156	PATU8988T	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.2322322923176119	[149]	[141,195,70,284]	4	hSpCas9	negative selection	8733014
31059211	31059234	8	-	27260156	PATU8988T	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.21929857519883666	[689]	[408,678,646,563]	-4	hSpCas9	negative selection	8797260
31064972	31064995	8	+	27260156	PATU8988T	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.7048315231610258	[383]	[106,269,292,244]	-8	hSpCas9	negative selection	8797261
31065042	31065065	8	+	27260156	PATU8988T	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.7140551373766318	[460]	[751,690,890,569]	9	hSpCas9	negative selection	8797262
31064284	31064307	8	+	27260156	T47D	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.13974594759292536	[933]	[1150,1102,1153,1401]	3	hSpCas9	negative selection	8854263
31064413	31064436	8	+	27260156	T47D	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.4167726137522424	[657]	[1080,947,1012,1058]	8	hSpCas9	negative selection	8854264
31059186	31059209	8	+	27260156	T47D	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.5809070872507522	[149]	[321,182,288,257]	9	hSpCas9	negative selection	8854265
31059211	31059234	8	-	27260156	T47D	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.05985546732800667	[689]	[783,710,759,836]	-1	hSpCas9	negative selection	8918511
31064972	31064995	8	+	27260156	T47D	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.09211687569290594	[383]	[360,357,436,530]	-2	hSpCas9	negative selection	8918512
31065042	31065065	8	+	27260156	T47D	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.3258235015738864	[460]	[745,548,662,747]	7	hSpCas9	negative selection	8918513
31064284	31064307	8	+	27260156	SU8686	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.23503546951094856	[933]	[745,540,802,1146]	-4	hSpCas9	negative selection	8975514
31064413	31064436	8	+	27260156	SU8686	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.31735322492284945	[657]	[845,721,843,847]	5	hSpCas9	negative selection	8975515
31059186	31059209	8	+	27260156	SU8686	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.4596486815937766	[149]	[197,172,206,250]	7	hSpCas9	negative selection	8975516
31059211	31059234	8	-	27260156	SU8686	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.20502073733807685	[689]	[533,587,562,709]	-4	hSpCas9	negative selection	9039762
31064972	31064995	8	+	27260156	SU8686	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.13762862288095135	[383]	[291,330,372,403]	-2	hSpCas9	negative selection	9039763
31065042	31065065	8	+	27260156	SU8686	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.41095687404439574	[460]	[513,739,488,685]	7	hSpCas9	negative selection	9039764
31064284	31064307	8	+	27260156	SKES1	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.06560817828517573	[933]	[933,1006,1013,936]	1	hSpCas9	negative selection	9096765
31064413	31064436	8	+	27260156	SKES1	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.2750337952174813	[657]	[912,910,595,782]	6	hSpCas9	negative selection	9096766
31059186	31059209	8	+	27260156	SKES1	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.3937126193751326	[149]	[176,207,171,222]	7	hSpCas9	negative selection	9096767
31059211	31059234	8	-	27260156	SKES1	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.010368451156993475	[689]	[792,666,663,622]	0	hSpCas9	negative selection	9161013
31064972	31064995	8	+	27260156	SKES1	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.031085047161833856	[383]	[380,412,327,435]	0	hSpCas9	negative selection	9161014
31065042	31065065	8	+	27260156	SKES1	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.07364920179629182	[460]	[577,436,557,376]	1	hSpCas9	negative selection	9161015
31064284	31064307	8	+	27260156	TOV112D	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.09770935748263077	[933]	[1032,1058,697,1222]	2	hSpCas9	negative selection	9218016
31064413	31064436	8	+	27260156	TOV112D	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.48284512865139717	[657]	[1380,1047,605,722]	8	hSpCas9	negative selection	9218017
31059186	31059209	8	+	27260156	TOV112D	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.47966935184962534	[149]	[160,196,137,330]	8	hSpCas9	negative selection	9218018
31059211	31059234	8	-	27260156	TOV112D	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	0.04296048300585442	[689]	[597,760,809,680]	0	hSpCas9	negative selection	9282264
31064972	31064995	8	+	27260156	TOV112D	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.12582930911892448	[383]	[545,492,371,298]	2	hSpCas9	negative selection	9282265
31065042	31065065	8	+	27260156	TOV112D	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.09733193029695832	[460]	[679,697,428,240]	2	hSpCas9	negative selection	9282266
31064284	31064307	8	+	27260156	TC71	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	0.13339517306531856	[933]	[1069,1177,957,1197]	3	hSpCas9	negative selection	9339267
31064413	31064436	8	+	27260156	TC71	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.2666802172367595	[657]	[941,709,826,917]	6	hSpCas9	negative selection	9339268
31059186	31059209	8	+	27260156	TC71	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.13661763778776304	[149]	[194,185,124,203]	3	hSpCas9	negative selection	9339269
31059211	31059234	8	-	27260156	TC71	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.17297403653740345	[689]	[597,667,701,655]	-4	hSpCas9	negative selection	9403515
31064972	31064995	8	+	27260156	TC71	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	0.02634480632345404	[383]	[369,478,421,405]	0	hSpCas9	negative selection	9403516
31065042	31065065	8	+	27260156	TC71	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.2776213210030471	[460]	[660,656,585,483]	6	hSpCas9	negative selection	9403517
31064284	31064307	8	+	27260156	TC32	viability	TTTAGCATGAGTCTATCAGATGG	WRN	ENSG00000165392	-0.19377694093337672	[933]	[858,482,1034,790]	-3	hSpCas9	negative selection	9460518
31064413	31064436	8	+	27260156	TC32	viability	TTCCACGTTTCTTCCATGTCAGG	WRN	ENSG00000165392	0.10048854829549381	[657]	[691,423,749,859]	1	hSpCas9	negative selection	9460519
31059186	31059209	8	+	27260156	TC32	viability	CTCCCCTTCTTAGAATTCACTGG	WRN	ENSG00000165392	0.34620087110800557	[149]	[137,100,252,267]	6	hSpCas9	negative selection	9460520
31059211	31059234	8	-	27260156	TC32	viability	AGCATCGTAACTATACACAATGG	WRN	ENSG00000165392	-0.37031169452104185	[689]	[571,331,662,491]	-6	hSpCas9	negative selection	9524766
31064972	31064995	8	+	27260156	TC32	viability	TAGGAATTGAAGGAGATCAGTGG	WRN	ENSG00000165392	-0.8771301725950119	[383]	[239,64,268,261]	-9	hSpCas9	negative selection	9524767
31065042	31065065	8	+	27260156	TC32	viability	GACAGATGTTGCCAATAAAAAGG	WRN	ENSG00000165392	0.3822573659873667	[460]	[555,497,542,652]	6	hSpCas9	negative selection	9524768
31090511	31090534	8	+	27869803	HPAFII	viability after 27 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	1.0939836178750906	[86]	[191,18,NaN]	8	hSpCas9	negative selection	9602457
31100934	31100957	8	+	27869803	HPAFII	viability after 27 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-6.456123838098349	[166]	[0,0,NaN]	-9	hSpCas9	negative selection	9602458
31116449	31116472	8	-	27869803	HPAFII	viability after 27 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-0.9252910290427083	[220]	[22,92,NaN]	-6	hSpCas9	negative selection	9602459
31120308	31120331	8	+	27869803	HPAFII	viability after 27 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-3.4601731404016234	[372]	[13,20,NaN]	-9	hSpCas9	negative selection	9602460
31141460	31141483	8	+	27869803	HPAFII	viability after 27 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-0.6339230735214639	[182]	[49,71,NaN]	-4	hSpCas9	negative selection	9602461
31157409	31157432	8	+	27869803	HPAFII	viability after 27 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-1.2998436540484244	[469]	[161,48,NaN]	-7	hSpCas9	negative selection	9602462
31090511	31090534	8	+	27869803	HPAFII	viability after 15 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	0.9795088779729783	[86]	[348,81,NaN]	9	hSpCas9	negative selection	9684906
31100934	31100957	8	+	27869803	HPAFII	viability after 15 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-0.9121460107490502	[166]	[177,43,NaN]	-7	hSpCas9	negative selection	9684907
31116449	31116472	8	-	27869803	HPAFII	viability after 15 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	0.3342374471324966	[220]	[349,267,NaN]	4	hSpCas9	negative selection	9684908
31120308	31120331	8	+	27869803	HPAFII	viability after 15 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-1.9100245791113588	[372]	[118,98,NaN]	-9	hSpCas9	negative selection	9684909
31141460	31141483	8	+	27869803	HPAFII	viability after 15 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	0.6454728887917474	[182]	[483,197,NaN]	7	hSpCas9	negative selection	9684910
31157409	31157432	8	+	27869803	HPAFII	viability after 15 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-0.3785170666299559	[469]	[612,248,NaN]	-4	hSpCas9	negative selection	9684911
31090511	31090534	8	+	27869803	ASPC1	viability after 36 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	0.495901616402979	[325]	[129,297,70]	5	hSpCas9	negative selection	9767355
31100934	31100957	8	+	27869803	ASPC1	viability after 36 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-0.004067284019037332	[465]	[228,191,89]	0	hSpCas9	negative selection	9767356
31116449	31116472	8	-	27869803	ASPC1	viability after 36 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	0.44726389490819496	[586]	[247,187,370]	4	hSpCas9	negative selection	9767357
31120308	31120331	8	+	27869803	ASPC1	viability after 36 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-0.1277090165213628	[857]	[291,172,338]	-1	hSpCas9	negative selection	9767358
31141460	31141483	8	+	27869803	ASPC1	viability after 36 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	0.006120896142357335	[628]	[274,358,69]	0	hSpCas9	negative selection	9767359
31157409	31157432	8	+	27869803	ASPC1	viability after 36 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	0.5247555831832701	[1192]	[647,653,514]	5	hSpCas9	negative selection	9767360
31090511	31090534	8	+	27869803	PATU8988S	viability after 35 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	-0.07938615472664146	[213]	[113,48,NaN]	-1	hSpCas9	negative selection	9849804
31100934	31100957	8	+	27869803	PATU8988S	viability after 35 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-0.9126968003691378	[588]	[129,121,NaN]	-7	hSpCas9	negative selection	9849805
31116449	31116472	8	-	27869803	PATU8988S	viability after 35 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-1.27624251506146	[603]	[71,128,NaN]	-8	hSpCas9	negative selection	9849806
31120308	31120331	8	+	27869803	PATU8988S	viability after 35 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-1.2740544672227045	[732]	[152,90,NaN]	-8	hSpCas9	negative selection	9849807
31141460	31141483	8	+	27869803	PATU8988S	viability after 35 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-0.7077281410706113	[561]	[176,99,NaN]	-6	hSpCas9	negative selection	9849808
31157409	31157432	8	+	27869803	PATU8988S	viability after 35 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-0.6680475413458796	[1155]	[299,285,NaN]	-6	hSpCas9	negative selection	9849809
31090511	31090534	8	+	27869803	PATU8988S	viability after 31 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	-0.11478473928682176	[213]	[102,47,NaN]	-1	hSpCas9	negative selection	9932253
31100934	31100957	8	+	27869803	PATU8988S	viability after 31 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-1.1907768432295869	[588]	[123,75,NaN]	-8	hSpCas9	negative selection	9932254
31116449	31116472	8	-	27869803	PATU8988S	viability after 31 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-0.6701137906537067	[603]	[142,161,NaN]	-6	hSpCas9	negative selection	9932255
31120308	31120331	8	+	27869803	PATU8988S	viability after 31 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-0.8739434195214759	[732]	[173,140,NaN]	-7	hSpCas9	negative selection	9932256
31141460	31141483	8	+	27869803	PATU8988S	viability after 31 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-0.910202833644693	[561]	[131,102,NaN]	-7	hSpCas9	negative selection	9932257
31157409	31157432	8	+	27869803	PATU8988S	viability after 31 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-0.6364764152449898	[1155]	[292,300,NaN]	-6	hSpCas9	negative selection	9932258
31090511	31090534	8	+	27869803	HPAFII	viability after 35 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	0.7478276288060642	[86]	[112,29,NaN]	5	hSpCas9	negative selection	10014702
31100934	31100957	8	+	27869803	HPAFII	viability after 35 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-6.401615739477378	[166]	[0,0,NaN]	-9	hSpCas9	negative selection	10014703
31116449	31116472	8	-	27869803	HPAFII	viability after 35 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-1.3680578227922675	[220]	[24,63,NaN]	-6	hSpCas9	negative selection	10014704
31120308	31120331	8	+	27869803	HPAFII	viability after 35 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-2.724156910114393	[372]	[5,53,NaN]	-8	hSpCas9	negative selection	10014705
31141460	31141483	8	+	27869803	HPAFII	viability after 35 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-1.1494631654293133	[182]	[37,45,NaN]	-6	hSpCas9	negative selection	10014706
31157409	31157432	8	+	27869803	HPAFII	viability after 35 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-1.994396899822462	[469]	[78,37,NaN]	-7	hSpCas9	negative selection	10014707
31090511	31090534	8	+	27869803	HPAFII	viability after 31 days	AATGTTGCTGTCATGGCAACTGG	WRN	ENSG00000165392	1.3061363899218186	[86]	[192,41,NaN]	8	hSpCas9	negative selection	10097151
31100934	31100957	8	+	27869803	HPAFII	viability after 31 days	CCTAAAGACAGCACTGCCAATGG	WRN	ENSG00000165392	-6.550333092798795	[166]	[0,0,NaN]	-9	hSpCas9	negative selection	10097152
31116449	31116472	8	-	27869803	HPAFII	viability after 31 days	GCCCGCATGGTATGTTCCACAGG	WRN	ENSG00000165392	-2.358874258198781	[220]	[16,31,NaN]	-8	hSpCas9	negative selection	10097153
31120308	31120331	8	+	27869803	HPAFII	viability after 31 days	TTACGGTGCTCCTAAGGACATGG	WRN	ENSG00000165392	-3.567480609620572	[372]	[9,25,NaN]	-9	hSpCas9	negative selection	10097154
31141460	31141483	8	+	27869803	HPAFII	viability after 31 days	AGGCACAGTTTATTTGGCACTGG	WRN	ENSG00000165392	-0.2584623799552036	[182]	[37,137,NaN]	-2	hSpCas9	negative selection	10097155
31157409	31157432	8	+	27869803	HPAFII	viability after 31 days	TGGCATGCACTTATCCCAAGCGG	WRN	ENSG00000165392	-1.3693066908993028	[469]	[148,50,NaN]	-7	hSpCas9	negative selection	10097156
31076266	31076289	8	+	28162770	P31FUJ	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	-0.7258422156944957	[37]	[26]	-5	hSpCas9	negative selection	10265748
31147425	31147448	8	-	28162770	P31FUJ	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	-0.07007270437627011	[535]	[599]	0	hSpCas9	negative selection	10265749
31111764	31111787	8	-	28162770	P31FUJ	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	0.4912243340443294	[223]	[369]	5	hSpCas9	negative selection	10265750
31147438	31147461	8	+	28162770	P31FUJ	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-1.0991237691824094	[205]	[112]	-6	hSpCas9	negative selection	10265751
31058464	31058487	8	+	28162770	P31FUJ	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	3.196364371604865e-05	[176]	[207]	0	hSpCas9	negative selection	10265752
31059185	31059208	8	-	28162770	P31FUJ	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	0.8867364937841598	[190]	[414]	8	hSpCas9	negative selection	10265753
31064426	31064449	8	-	28162770	P31FUJ	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	-0.7750224217654372	[714]	[490]	-6	hSpCas9	negative selection	10265754
31067169	31067192	8	-	28162770	P31FUJ	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.004113140455533237	[705]	[831]	0	hSpCas9	negative selection	10265755
31116433	31116456	8	+	28162770	P31FUJ	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	-0.4776540762831	[409]	[345]	-4	hSpCas9	negative selection	10265756
31141482	31141505	8	+	28162770	P31FUJ	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	-1.6038963561056252	[193]	[74]	-7	hSpCas9	negative selection	10265757
31076266	31076289	8	+	28162770	TF1	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	NaN	[NaN]	[11]	1	hSpCas9	negative selection	10435114
31147425	31147448	8	-	28162770	TF1	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	NaN	[NaN]	[429]	1	hSpCas9	negative selection	10435115
31111764	31111787	8	-	28162770	TF1	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	NaN	[NaN]	[437]	1	hSpCas9	negative selection	10435116
31147438	31147461	8	+	28162770	TF1	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	NaN	[NaN]	[46]	1	hSpCas9	negative selection	10435117
31058464	31058487	8	+	28162770	TF1	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	NaN	[NaN]	[229]	1	hSpCas9	negative selection	10435118
31059185	31059208	8	-	28162770	TF1	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	NaN	[NaN]	[179]	1	hSpCas9	negative selection	10435119
31064426	31064449	8	-	28162770	TF1	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	NaN	[NaN]	[657]	1	hSpCas9	negative selection	10435120
31067169	31067192	8	-	28162770	TF1	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	NaN	[NaN]	[615]	1	hSpCas9	negative selection	10435121
31116433	31116456	8	+	28162770	TF1	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	NaN	[NaN]	[242]	1	hSpCas9	negative selection	10435122
31141482	31141505	8	+	28162770	TF1	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	NaN	[NaN]	[80]	1	hSpCas9	negative selection	10435123
31076266	31076289	8	+	28162770	SKM1	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	-1.6964708159381465	[10]	[5]	-8	hSpCas9	negative selection	10604480
31147425	31147448	8	-	28162770	SKM1	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.7708229204721211	[121]	[367]	7	hSpCas9	negative selection	10604481
31111764	31111787	8	-	28162770	SKM1	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	0.8962273335626147	[61]	[203]	8	hSpCas9	negative selection	10604482
31147438	31147461	8	+	28162770	SKM1	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-0.06816228529140309	[50]	[85]	0	hSpCas9	negative selection	10604483
31058464	31058487	8	+	28162770	SKM1	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	0.3255554903918523	[64]	[143]	3	hSpCas9	negative selection	10604484
31059185	31059208	8	-	28162770	SKM1	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	1.079817908039091	[56]	[212]	8	hSpCas9	negative selection	10604485
31064426	31064449	8	-	28162770	SKM1	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	-0.412889032700267	[182]	[242]	-3	hSpCas9	negative selection	10604486
31067169	31067192	8	-	28162770	SKM1	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.09932398785008179	[178]	[338]	0	hSpCas9	negative selection	10604487
31116433	31116456	8	+	28162770	SKM1	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	0.42145233884227223	[67]	[160]	4	hSpCas9	negative selection	10604488
31141482	31141505	8	+	28162770	SKM1	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	0.4003907233144425	[47]	[111]	4	hSpCas9	negative selection	10604489
31076266	31076289	8	+	28162770	SKM1	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	-1.6964708159381465	[10]	[5]	-8	hSpCas9	negative selection	10773846
31147425	31147448	8	-	28162770	SKM1	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.7708229204721211	[121]	[367]	7	hSpCas9	negative selection	10773847
31111764	31111787	8	-	28162770	SKM1	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	0.8962273335626147	[61]	[203]	8	hSpCas9	negative selection	10773848
31147438	31147461	8	+	28162770	SKM1	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-0.06816228529140309	[50]	[85]	0	hSpCas9	negative selection	10773849
31058464	31058487	8	+	28162770	SKM1	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	0.3255554903918523	[64]	[143]	3	hSpCas9	negative selection	10773850
31059185	31059208	8	-	28162770	SKM1	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	1.079817908039091	[56]	[212]	8	hSpCas9	negative selection	10773851
31064426	31064449	8	-	28162770	SKM1	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	-0.412889032700267	[182]	[242]	-3	hSpCas9	negative selection	10773852
31067169	31067192	8	-	28162770	SKM1	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.09932398785008179	[178]	[338]	0	hSpCas9	negative selection	10773853
31116433	31116456	8	+	28162770	SKM1	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	0.42145233884227223	[67]	[160]	4	hSpCas9	negative selection	10773854
31141482	31141505	8	+	28162770	SKM1	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	0.4003907233144425	[47]	[111]	4	hSpCas9	negative selection	10773855
31076266	31076289	8	+	28162770	PL21	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	2.2490492149702668	[28]	[59]	9	hSpCas9	negative selection	10943212
31147425	31147448	8	-	28162770	PL21	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.3773326163956716	[351]	[198]	3	hSpCas9	negative selection	10943213
31111764	31111787	8	-	28162770	PL21	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	-0.02636891531935981	[233]	[99]	0	hSpCas9	negative selection	10943214
31147438	31147461	8	+	28162770	PL21	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-1.2540362786964818	[273]	[49]	-7	hSpCas9	negative selection	10943215
31058464	31058487	8	+	28162770	PL21	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	-0.22612514021277796	[257]	[95]	-2	hSpCas9	negative selection	10943216
31059185	31059208	8	-	28162770	PL21	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	0.18882430126148592	[255]	[126]	1	hSpCas9	negative selection	10943217
31064426	31064449	8	-	28162770	PL21	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	0.22804561105920462	[511]	[260]	2	hSpCas9	negative selection	10943218
31067169	31067192	8	-	28162770	PL21	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.13785533623497748	[567]	[271]	1	hSpCas9	negative selection	10943219
31116433	31116456	8	+	28162770	PL21	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	0.4923203659826303	[293]	[179]	4	hSpCas9	negative selection	10943220
31141482	31141505	8	+	28162770	PL21	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	0.2814397165911684	[137]	[72]	2	hSpCas9	negative selection	10943221
31076266	31076289	8	+	28162770	P31FUJ	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	-0.7258422156944957	[37]	[26]	-5	hSpCas9	negative selection	11112578
31147425	31147448	8	-	28162770	P31FUJ	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	-0.07007270437627011	[535]	[599]	0	hSpCas9	negative selection	11112579
31111764	31111787	8	-	28162770	P31FUJ	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	0.4912243340443294	[223]	[369]	5	hSpCas9	negative selection	11112580
31147438	31147461	8	+	28162770	P31FUJ	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-1.0991237691824094	[205]	[112]	-6	hSpCas9	negative selection	11112581
31058464	31058487	8	+	28162770	P31FUJ	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	3.196364371604865e-05	[176]	[207]	0	hSpCas9	negative selection	11112582
31059185	31059208	8	-	28162770	P31FUJ	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	0.8867364937841598	[190]	[414]	8	hSpCas9	negative selection	11112583
31064426	31064449	8	-	28162770	P31FUJ	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	-0.7750224217654372	[714]	[490]	-6	hSpCas9	negative selection	11112584
31067169	31067192	8	-	28162770	P31FUJ	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.004113140455533237	[705]	[831]	0	hSpCas9	negative selection	11112585
31116433	31116456	8	+	28162770	P31FUJ	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	-0.4776540762831	[409]	[345]	-4	hSpCas9	negative selection	11112586
31141482	31141505	8	+	28162770	P31FUJ	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	-1.6038963561056252	[193]	[74]	-7	hSpCas9	negative selection	11112587
31076266	31076289	8	+	28162770	OCIAML5	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	-1.5890321650302028	[29]	[17]	-7	hSpCas9	negative selection	11281944
31147425	31147448	8	-	28162770	OCIAML5	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.3868849423458607	[296]	[700]	3	hSpCas9	negative selection	11281945
31111764	31111787	8	-	28162770	OCIAML5	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	1.5123448553448788	[86]	[447]	9	hSpCas9	negative selection	11281946
31147438	31147461	8	+	28162770	OCIAML5	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-0.39985927899461243	[181]	[248]	-3	hSpCas9	negative selection	11281947
31058464	31058487	8	+	28162770	OCIAML5	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	0.6631075997002968	[119]	[342]	6	hSpCas9	negative selection	11281948
31059185	31059208	8	-	28162770	OCIAML5	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	0.9865127599288548	[110]	[396]	8	hSpCas9	negative selection	11281949
31064426	31064449	8	-	28162770	OCIAML5	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	0.9169515454992256	[364]	[1243]	7	hSpCas9	negative selection	11281950
31067169	31067192	8	-	28162770	OCIAML5	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.6414363619798187	[368]	[1038]	5	hSpCas9	negative selection	11281951
31116433	31116456	8	+	28162770	OCIAML5	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	0.13637639771360344	[187]	[372]	1	hSpCas9	negative selection	11281952
31141482	31141505	8	+	28162770	OCIAML5	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	-0.35100532775178606	[117]	[166]	-2	hSpCas9	negative selection	11281953
31076266	31076289	8	+	28162770	EOL1	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	-0.42594947551359885	[50]	[19]	-3	hSpCas9	negative selection	11451310
31147425	31147448	8	-	28162770	EOL1	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.2709379238998082	[537]	[341]	2	hSpCas9	negative selection	11451311
31111764	31111787	8	-	28162770	EOL1	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	-0.09080019276290158	[377]	[186]	0	hSpCas9	negative selection	11451312
31147438	31147461	8	+	28162770	EOL1	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	0.059597731734387316	[427]	[234]	0	hSpCas9	negative selection	11451313
31058464	31058487	8	+	28162770	EOL1	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	-0.6782260052670821	[488]	[160]	-5	hSpCas9	negative selection	11451314
31059185	31059208	8	-	28162770	EOL1	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	1.060040970463237	[456]	[501]	8	hSpCas9	negative selection	11451315
31064426	31064449	8	-	28162770	EOL1	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	0.7056766969686101	[681]	[585]	6	hSpCas9	negative selection	11451316
31067169	31067192	8	-	28162770	EOL1	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.09969294482802726	[704]	[397]	0	hSpCas9	negative selection	11451317
31116433	31116456	8	+	28162770	EOL1	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	0.39083151116480275	[400]	[276]	3	hSpCas9	negative selection	11451318
31141482	31141505	8	+	28162770	EOL1	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	-1.3028627245325377	[191]	[40]	-7	hSpCas9	negative selection	11451319
31076266	31076289	8	+	28162770	MOLM13	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	0.1630348000161579	[41]	[33]	1	hSpCas9	negative selection	11620676
31147425	31147448	8	-	28162770	MOLM13	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	-0.23525454552489156	[533]	[327]	-1	hSpCas9	negative selection	11620677
31111764	31111787	8	-	28162770	MOLM13	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	0.5402200695001358	[388]	[408]	4	hSpCas9	negative selection	11620678
31147438	31147461	8	+	28162770	MOLM13	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-0.020729250115372355	[361]	[257]	0	hSpCas9	negative selection	11620679
31058464	31058487	8	+	28162770	MOLM13	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	0.8861725403270766	[332]	[444]	6	hSpCas9	negative selection	11620680
31059185	31059208	8	-	28162770	MOLM13	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	1.0226899117554826	[289]	[425]	7	hSpCas9	negative selection	11620681
31064426	31064449	8	-	28162770	MOLM13	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	-0.05859465391084795	[833]	[578]	0	hSpCas9	negative selection	11620682
31067169	31067192	8	-	28162770	MOLM13	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	-0.6528365167774274	[871]	[400]	-4	hSpCas9	negative selection	11620683
31116433	31116456	8	+	28162770	MOLM13	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	-0.6549673662409548	[489]	[224]	-4	hSpCas9	negative selection	11620684
31141482	31141505	8	+	28162770	MOLM13	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	-0.8275665019815925	[215]	[87]	-4	hSpCas9	negative selection	11620685
31076266	31076289	8	+	28162770	HEL	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	1.6626383894380616	[35]	[72]	9	hSpCas9	negative selection	11790042
31147425	31147448	8	-	28162770	HEL	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.8261371217209412	[449]	[510]	7	hSpCas9	negative selection	11790043
31111764	31111787	8	-	28162770	HEL	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	1.0215939949725543	[322]	[419]	8	hSpCas9	negative selection	11790044
31147438	31147461	8	+	28162770	HEL	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-0.6791892628870053	[329]	[131]	-4	hSpCas9	negative selection	11790045
31058464	31058487	8	+	28162770	HEL	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	1.6222019009976623	[282]	[557]	9	hSpCas9	negative selection	11790046
31059185	31059208	8	-	28162770	HEL	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	0.6620393879592932	[296]	[300]	5	hSpCas9	negative selection	11790047
31064426	31064449	8	-	28162770	HEL	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	0.7742436151288488	[722]	[791]	6	hSpCas9	negative selection	11790048
31067169	31067192	8	-	28162770	HEL	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.31710948337455513	[682]	[544]	2	hSpCas9	negative selection	11790049
31116433	31116456	8	+	28162770	HEL	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	-0.03723678358101967	[454]	[283]	0	hSpCas9	negative selection	11790050
31141482	31141505	8	+	28162770	HEL	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	-0.6593807818068251	[216]	[87]	-4	hSpCas9	negative selection	11790051
31076266	31076289	8	+	28162770	MV411	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	-0.27339461251866526	[32]	[22]	-2	hSpCas9	negative selection	11959408
31147425	31147448	8	-	28162770	MV411	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	-0.15244772326352152	[441]	[334]	-1	hSpCas9	negative selection	11959409
31111764	31111787	8	-	28162770	MV411	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	0.41286115999014683	[213]	[239]	3	hSpCas9	negative selection	11959410
31147438	31147461	8	+	28162770	MV411	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-1.5368337581617877	[216]	[62]	-7	hSpCas9	negative selection	11959411
31058464	31058487	8	+	28162770	MV411	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	0.38494107453271015	[239]	[263]	3	hSpCas9	negative selection	11959412
31059185	31059208	8	-	28162770	MV411	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	1.0622226783158677	[165]	[291]	8	hSpCas9	negative selection	11959413
31064426	31064449	8	-	28162770	MV411	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	0.6339356438476924	[484]	[633]	6	hSpCas9	negative selection	11959414
31067169	31067192	8	-	28162770	MV411	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	-0.13291810911135515	[547]	[420]	-1	hSpCas9	negative selection	11959415
31116433	31116456	8	+	28162770	MV411	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	0.5037773040425608	[287]	[343]	4	hSpCas9	negative selection	11959416
31141482	31141505	8	+	28162770	MV411	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	0.6520584341162806	[138]	[183]	6	hSpCas9	negative selection	11959417
31076266	31076289	8	+	28162770	MONOMAC1	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	0.31753632577020463	[20]	[29]	3	hSpCas9	negative selection	12128774
31147425	31147448	8	-	28162770	MONOMAC1	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.03652266518062386	[238]	[280]	0	hSpCas9	negative selection	12128775
31111764	31111787	8	-	28162770	MONOMAC1	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	0.5442288845402782	[133]	[223]	5	hSpCas9	negative selection	12128776
31147438	31147461	8	+	28162770	MONOMAC1	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-0.38259250021563024	[173]	[152]	-3	hSpCas9	negative selection	12128777
31058464	31058487	8	+	28162770	MONOMAC1	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	0.7812680818411275	[133]	[263]	7	hSpCas9	negative selection	12128778
31059185	31059208	8	-	28162770	MONOMAC1	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	0.46479441704587304	[133]	[211]	4	hSpCas9	negative selection	12128779
31064426	31064449	8	-	28162770	MONOMAC1	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	0.19759444155745287	[355]	[467]	2	hSpCas9	negative selection	12128780
31067169	31067192	8	-	28162770	MONOMAC1	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	1.0134274778794996	[346]	[802]	8	hSpCas9	negative selection	12128781
31116433	31116456	8	+	28162770	MONOMAC1	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	0.23480893990584406	[191]	[258]	2	hSpCas9	negative selection	12128782
31141482	31141505	8	+	28162770	MONOMAC1	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	-0.9640596750819397	[96]	[56]	-6	hSpCas9	negative selection	12128783
31076266	31076289	8	+	28162770	OCIAML2	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	-1.6632749031845573	[7]	[13]	-7	hSpCas9	negative selection	12298140
31147425	31147448	8	-	28162770	OCIAML2	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.2898294715909814	[66]	[453]	2	hSpCas9	negative selection	12298141
31111764	31111787	8	-	28162770	OCIAML2	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	1.0714608682179871	[36]	[430]	8	hSpCas9	negative selection	12298142
31147438	31147461	8	+	28162770	OCIAML2	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-0.6158277407820967	[46]	[169]	-4	hSpCas9	negative selection	12298143
31058464	31058487	8	+	28162770	OCIAML2	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	-0.25912572004844936	[56]	[263]	-2	hSpCas9	negative selection	12298144
31059185	31059208	8	-	28162770	OCIAML2	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	-0.07696597675588429	[50]	[267]	0	hSpCas9	negative selection	12298145
31064426	31064449	8	-	28162770	OCIAML2	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	0.08227146624669657	[90]	[533]	0	hSpCas9	negative selection	12298146
31067169	31067192	8	-	28162770	OCIAML2	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.5605889053685591	[79]	[653]	5	hSpCas9	negative selection	12298147
31116433	31116456	8	+	28162770	OCIAML2	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	-0.8450253400236591	[69]	[215]	-5	hSpCas9	negative selection	12298148
31141482	31141505	8	+	28162770	OCIAML2	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	-0.4233241104638046	[29]	[123]	-3	hSpCas9	negative selection	12298149
31076266	31076289	8	+	28162770	OCIAML3	viability	GTAAATTGGAAAACCCACGGAGG	WRN	ENSG00000165392	-2.4013625623817676	[13]	[7]	-9	hSpCas9	negative selection	12467506
31147425	31147448	8	-	28162770	OCIAML3	viability	GTTTGTTGCCAGAATAGCTGGGG	WRN	ENSG00000165392	0.8624401198743126	[87]	[482]	7	hSpCas9	negative selection	12467507
31111764	31111787	8	-	28162770	OCIAML3	viability	GAAATGGCTGCAGATCCTGAAGG	WRN	ENSG00000165392	0.044726116837973895	[78]	[245]	0	hSpCas9	negative selection	12467508
31147438	31147461	8	+	28162770	OCIAML3	viability	GGCAACAAACAAGATACTGGTGG	WRN	ENSG00000165392	-1.1682437344522607	[66]	[89]	-7	hSpCas9	negative selection	12467509
31058464	31058487	8	+	28162770	OCIAML3	viability	TGGAAACAACTGCACAGCAGCGG	WRN	ENSG00000165392	0.21092054433890084	[84]	[296]	2	hSpCas9	negative selection	12467510
31059185	31059208	8	-	28162770	OCIAML3	viability	CAGTGAATTCTAAGAAGGGGAGG	WRN	ENSG00000165392	1.0010790776707004	[70]	[428]	8	hSpCas9	negative selection	12467511
31064426	31064449	8	-	28162770	OCIAML3	viability	GTAGAGATACCAACCTGACATGG	WRN	ENSG00000165392	0.27440880746971974	[151]	[554]	2	hSpCas9	negative selection	12467512
31067169	31067192	8	-	28162770	OCIAML3	viability	AGCACGTACATAAGCATCAGTGG	WRN	ENSG00000165392	0.4923526444790183	[153]	[653]	4	hSpCas9	negative selection	12467513
31116433	31116456	8	+	28162770	OCIAML3	viability	AGGAAACTGAATCTATCCTGTGG	WRN	ENSG00000165392	0.29907715575932503	[76]	[285]	3	hSpCas9	negative selection	12467514
31141482	31141505	8	+	28162770	OCIAML3	viability	GCAAGGATCAAACAGAGAGTTGG	WRN	ENSG00000165392	0.7113375703675952	[34]	[172]	6	hSpCas9	negative selection	12467515