Disease Annotation

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 348
  • Symbol: APOE
  • Description: apolipoprotein E

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Disease_Term Source Rank Other Values
Sea-blue histiocyte disease, 269600 (3) OMIM high
  • Genome region : 19q13.32
  • OMIM_ID : 107741 OMIM gene ID
  • OMIM_ID : 269600 OMIM phenotype ID
Lipoprotein glomerulopathy, 611771 (3) OMIM high
  • Genome region : 19q13.32
  • OMIM_ID : 107741 OMIM gene ID
  • OMIM_ID : 611771 OMIM phenotype ID
Hyperlipoproteinemia, type III, 617347 (3) OMIM high
  • Genome region : 19q13.32
  • OMIM_ID : 107741 OMIM gene ID
  • OMIM_ID : 617347 OMIM phenotype ID
Alzheimer disease-2, 104310 (3) OMIM high
  • Genome region : 19q13.32
  • OMIM_ID : 104310 OMIM phenotype ID
  • OMIM_ID : 107741 OMIM gene ID
{?Macular degeneration, age-related}, 603075 (3) OMIM high
  • Genome region : 19q13.32
  • OMIM_ID : 107741 OMIM gene ID
  • OMIM_ID : 603075 OMIM phenotype ID
{Coronary artery disease, severe, susceptibility to}, 617347 (3) OMIM high
  • Genome region : 19q13.32
  • OMIM_ID : 107741 OMIM gene ID
  • OMIM_ID : 617347 OMIM phenotype ID
Cardiovascular disease risk factors GWAS high
Alzheimer's disease (age of onset) GWAS high
Metabolite levels GWAS high
Lipid traits GWAS high
Hippocampal atrophy GWAS high
Cholesterol, total GWAS high
Verbal declarative memory GWAS high
Blood metabolite ratios GWAS high
Psychosis and Alzheimer's disease GWAS high
Alzheimer disease and age of onset GWAS high
Longevity (85 years and older) GWAS high
LDL cholesterol levels GWAS high
Coronary artery disease GWAS high
Cerebral amyloid deposition (PET imaging) GWAS high
Sphingolipid levels GWAS high
Alzheimer's disease (late onset) GWAS high
Metabolite levels (lipoprotein measures) GWAS high
Cingulate cortical amyloid beta load GWAS high
Very long-chain saturated fatty acid levels (fatty acid 20:0) GWAS high
Body fat percentage GWAS high
Quantitative traits GWAS high
Longevity (90 years and older) GWAS high
Lewy body disease GWAS high
C-reactive protein GWAS high
Cerebral amyloid deposition positivity (PET imaging) GWAS high
Triglycerides GWAS high
Alzheimer's disease biomarkers GWAS high
Advanced age-related macular degeneration GWAS high
Lipoprotein-associated phospholipase A2 activity and mass GWAS high
Ideal cardiovascular health (clinical) GWAS high
Cognitive decline GWAS high
Brain imaging GWAS high
Response to statins (LDL cholesterol change) GWAS high
Alzheimer's disease GWAS high
Metabolic syndrome GWAS high
Lipid metabolism phenotypes GWAS high
HDL cholesterol GWAS high
Cerebrospinal AB1-42 levels in Alzheimer's disease dementia GWAS high
Type 2 diabetes GWAS high
Apolipoprotein Levels GWAS high
Posterior cortical atrophy and Alzheimer's disease GWAS high
Age-related macular degeneration GWAS high
Longevity GWAS high
LDL cholesterol GWAS high
Cognitive decline (age-related) GWAS high