Disease Annotation

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 3667
  • Symbol: IRS1
  • Description: insulin receptor substrate 1

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Disease_Term Source Rank Other Values
{Diabetes mellitus, noninsulin-dependent}, 125853 (3) OMIM high
  • Genome region : 11p11.2
  • Genome region : 13q34
  • Genome region : 15q21.3
  • Genome region : 17q25.3
  • Genome region : 20q13.12
  • Genome region : 2q31.3
  • Genome region : 2q36.3
  • Genome region : 3q26.2
  • OMIM_ID : 125853 OMIM phenotype ID
  • OMIM_ID : 138033 OMIM gene ID
  • OMIM_ID : 138160 OMIM gene ID
  • OMIM_ID : 147545 OMIM gene ID
  • OMIM_ID : 151670 OMIM gene ID
  • OMIM_ID : 600281 OMIM gene ID
  • OMIM_ID : 600797 OMIM gene ID
  • OMIM_ID : 601724 OMIM gene ID
  • OMIM_ID : 604641 OMIM gene ID
{Coronary artery disease, susceptibility to} (3) OMIM high
  • Genome region : 13q13.1
  • Genome region : 2q36.3
  • Genome region : 7q21.3
  • OMIM_ID : 147545 OMIM gene ID
  • OMIM_ID : 168820 OMIM gene ID
  • OMIM_ID : 602447 OMIM gene ID
  • OMIM_ID : 604824 OMIM gene ID
Body fat percentage GWAS high
Modified Stumvoll Insulin Sensitivity Index GWAS high
Type 2 diabetes and other traits GWAS high
Fasting insulin-related traits (interaction with BMI) GWAS high
Sexual dimorphism in anthropometric traits GWAS high
Adiponectin levels GWAS high
Visceral adipose tissue/subcutaneous adipose tissue ratio GWAS high
Glucose homeostasis traits GWAS high
Triglycerides GWAS high
Adiposity GWAS high
HDL cholesterol GWAS high
Type 2 diabetes GWAS high