RNAi

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 34881
  • Symbol: Su(H)
  • Description: Suppressor of Hairless
DataSource: http://genomernai.dkfz.de/v16/genedetails/34881

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Stable_ID Entrez_ID Gene_ID Gene_Symbol Reagent_ID Score Phenotype Conditions Follow_Up Comment Screen_Title Publication_Title Authors Publication_Year Pubmed_ID Biosource Biomodel Assay Method Library Scope Reagent_Type Score_Type Cutoff Notes
GR00002-A 34881 FBgn0004837 Su(H) DRSC03445 -1.814731062 none no Lipid storage COPI complex is a regulator of lipid homeostasis. Beller et al. 2008 19067489 Cell line Kc167 Nuclear to lipid droplet cross-sectional area Fluorescence np Genome-wide dsRNA B-score > 2 OR < -1.7 Additional information about a secondary screen with non-overlaping dsRNAs
GR00002-A 34881 FBgn0004837 Su(H) DRSC03445 -0.083494048 none no Lipid storage COPI complex is a regulator of lipid homeostasis. Beller et al. 2008 19067489 Cell line Kc167 Nuclear to lipid droplet cross-sectional area Fluorescence np Genome-wide dsRNA B-score > 2 OR < -1.7 Additional information about a secondary screen with non-overlaping dsRNAs
GR00031-A-1 34881 HFA03445 0 none yes Cell growth and viability (1) Genome-wide RNAi analysis of growth and viability in Drosophila cells. Boutros et al. 2004 14764878 Cell line Kc167 Cell number and viability Luminescence Custom-made (HFA) Genome-wide dsRNA Z-score >
GR00031-A-2 34881 HFA03445 -0.5 none no Cell growth and viability (2) Genome-wide RNAi analysis of growth and viability in Drosophila cells. Boutros et al. 2004 14764878 Cell line S2R+ Cell number and viability Luminescence Custom-made (HFA) Genome-wide dsRNA Z-score >
34881 FBgn0004837 Su(H) GH10914 sp none no library: DGC1
34881 CG3497 Su(H) np np Defects in nervous system development no “Known” phenotype
34881 CG3497 Su(H) np np Posterior portion assembly defects, heart patterning defects no
GR00065-A 34881 CG3497 Su(H) Su(H) np none no Dendrite pattern formation Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Parrish et al. 2006 16547170 Tissue GAL4221 mCD8 protein expression Fluorescence Custom-made Transcription factors UAS-IR construct np Phenotypes in multiple blind tests Additional information about secondary screens
GR00128-A-1 34881 FBgn0004837 CG3497 DRSC03445 sp Synthetic lethal with methyl methanesulphonate no Combinatorial effect with methyl methanesulphonate (1) A network of conserved damage survival pathways revealed by a genomic RNAi screen. Ravi et al. 2009 19543366 Cell line Kc167 Viability (synthetic lethal) Luminescence Version 1 Genome-wide dsRNA rp rp Additional information about the primary screen
GR00128-A-2 34881 FBgn0004837 CG3497 DRSC37658 sp none no non-significantly decreased viability Combinatorial effect with methyl methanesulphonate (2) A network of conserved damage survival pathways revealed by a genomic RNAi screen. Ravi et al. 2009 19543366 Cell line Kc167 Viability (synthetic lethal) Luminescence Version 1 Selected genes dsRNA rp rp
GR00135-A-1 34881 CG3497 Su(H) 9925 -1.17 none yes Heat nociception (1) A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely et al. 2010 21074052 Organism elav-GAL4 Noxious heat avoidance and viability Fly count np Genome-wide UAS-IR construct Z-score > 1.65 Additional information about secondary screens (geotactic, phototaxis, and temperature sensitivity)
GR00137-A-1 34881 CG3497 np -0.3 none no decreased cell number or influenced reporter expression Regulated secretory pathway biogenesis (1) RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. Asensio et al. 2010 21149569 Cell line S2 dVMAT protein cell surface expression Flow cytometry DmRNAi library version 1 Selected genes dsRNA Z-score >
GR00142-A-1 34881 CG3497 Su(H) 9925 -0.419753086419753 none no Serratia marcescens infection (1) Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Cronin et al. 2009 19520911 Organism HSP70-GAL4; TubGAL80ts Heat shock and viability Fly count np Random genes UAS-IR construct Days life time (LT50) < -1.5 SD OR > 2 SD
GR00144-A-1 34881 CG3497 Su(H) 17H1 T2 no phenotype none temperature: 18 yes Notch pathway regulation (1) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue sca-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-1 34881 CG3497 Su(H) 17H1 T2 no phenotype none temperature: 25 yes Notch pathway regulation (1) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue sca-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-1 34881 CG3497 Su(H) 17H1 T2 no phenotype none temperature: 29 yes Notch pathway regulation (1) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue sca-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-1 34881 CG3497 Su(H) 17H1 T3 no phenotype none temperature: 25 yes Notch pathway regulation (1) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue sca-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-1 34881 CG3497 Su(H) 17H1 T3 no phenotype none temperature: 29 yes Notch pathway regulation (1) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue sca-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-2 34881 CG3497 Su(H) 17H1 T3 no phenotype none temperature: 29 yes Notch pathway regulation (2) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue fz3-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-2 34881 CG3497 Su(H) 17H1 T3 no phenotype none temperature: 25 yes Notch pathway regulation (2) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue fz3-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-2 34881 CG3497 Su(H) 17H1 T2 no phenotype none temperature: 18 yes Notch pathway regulation (2) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue fz3-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-2 34881 CG3497 Su(H) 17H1 T2 np Bad cross, phenotype not checked temperature: 29 yes Notch pathway regulation (2) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue fz3-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-2 34881 CG3497 Su(H) 17H1 T2 np Bad cross, phenotype not checked temperature: 25 yes Notch pathway regulation (2) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue fz3-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-3 34881 CG3497 Su(H) 17H1 T2 no phenotype none temperature: 18 yes Notch pathway regulation (3) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue pnr-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-3 34881 CG3497 Su(H) 17H1 T2 no phenotype none temperature: 25 yes Notch pathway regulation (3) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue pnr-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-3 34881 CG3497 Su(H) 17H1 T2 no phenotype none temperature: 29 yes Notch pathway regulation (3) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue pnr-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-3 34881 CG3497 Su(H) 17H1 T3 no phenotype none temperature: 25 yes Notch pathway regulation (3) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue pnr-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-3 34881 CG3497 Su(H) 17H1 T3 no phenotype none temperature: 29 yes Notch pathway regulation (3) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue pnr-GAL4 External sensory organ morphology and viability Visual inspection np Selected genes UAS-IR construct Phenotype strength np
GR00144-A-4 34881 CG3497 9925 0 none no partially lethal Notch pathway regulation (4) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer et al. 2009 19363474 Tissue pnr-GAL4 External sensory organ morphology and viability Visual inspection np Genome-wide UAS-IR construct Phenotype strength np
GR00152-A 34881 CG3497 Su(H) np -4.565 Downregulation of Notch pathway after Notch stimulation yes N(delta)ecn Notch stimulation; m3-luc normalization Notch induced transcription Modifiers of notch transcriptional activity identified by genome-wide RNAi. Mourikis et al. 2010 20959007 Cell line Kc167 Notch pathway reporter Luminescence np Genome-wide dsRNA Z-score < -2 OR > 2 (con-luc) OR < -1.8 OR > 1.8 (m3-luc) Additional information about secondary screens
GR00152-A 34881 CG3497 Su(H) np 1.6702 none yes without Notch stimulation Notch induced transcription Modifiers of notch transcriptional activity identified by genome-wide RNAi. Mourikis et al. 2010 20959007 Cell line Kc167 Notch pathway reporter Luminescence np Genome-wide dsRNA Z-score < -2 OR > 2 (con-luc) OR < -1.8 OR > 1.8 (m3-luc) Additional information about secondary screens
GR00152-A 34881 CG3497 Su(H) np -3.5355 Downregulation of Notch pathway after Notch stimulation yes N(delta)ecn Notch stimulation; con-luc normalization Notch induced transcription Modifiers of notch transcriptional activity identified by genome-wide RNAi. Mourikis et al. 2010 20959007 Cell line Kc167 Notch pathway reporter Luminescence np Genome-wide dsRNA Z-score < -2 OR > 2 (con-luc) OR < -1.8 OR > 1.8 (m3-luc) Additional information about secondary screens
GR00189-A-1 34881 FBgn0004837 Su(H) BKN21601 np Downregulation of Notch pathway yes Notch pathway regulation (1) A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. Saj et al. 2010 20493818 Cell line S2 Notch pathway reporter Luminescence BKN Genome-wide dsRNA Complex, sp Complex criteria
GR00189-A-2 34881 FBgn0004837 Su(H) 3497R-1 sp Wing disc NRE:EGFP: down; wing disc myrRFP: reduced; lethal yes en-GAL4; final gene scoring: downregulation of Notch pathway Notch pathway regulation (2) A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. Saj et al. 2010 20493818 Tissue en-GAL4, C96-GAL4 and vg-GAL4 Notch pathway reporter, wing imaginal discs morphology, adult wing morphology and viability Fluorescence and visual inspection Notch pathway component enriched RNAi library Selected genes UAS-IR construct Phenotype strength np
GR00189-A-3 34881 FBgn0004837 Su(H) np np none yes Notch pathway regulation (3) A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. Saj et al. 2010 20493818 Tissue GMR-GAL4 Notch pathway reporter Fluorescence Notch pathway component enriched RNAi library Selected genes UAS-IR construct Average fluorescent intensity Complex criteria
GR00190-A-1 34881 FBgn0004837 Su(H) 9925 -0.773 Decreased triglyceride expression yes Adiposity regulation (1) Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Pospisilik et al. 2010 20074523 Organism Hsp70-GAL4;Tub-GAL80ts Total fly triglyceride expression Colorimetrics np Genome-wide UAS-IR construct Triglyceride change Z-score > 1.65 after 3 screening rounds Additional information about the primary screen
GR00190-A-2 34881 FBgn0004837 Su(H) 9925 -0.492 Decreased triglyceride expression no Adiposity regulation (2) Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Pospisilik et al. 2010 20074523 Tissue nsyb-GAL4 Total fly triglyceride expression Colorimetrics np Selected genes UAS-IR construct Triglyceride change > 0.25 OR <-0.25 (change >25%) Additional information about the primary screen
GR00190-A-3 34881 FBgn0004837 Su(H) 9925 -0.276 Decreased triglyceride expression no Adiposity regulation (3) Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Pospisilik et al. 2010 20074523 Tissue C57-GAL4 Total fly triglyceride expression Colorimetrics np Selected genes UAS-IR construct Triglyceride change > 0.25 OR <-0.25 (change >25%) Additional information about the primary screen
GR00190-A-4 34881 FBgn0004837 Su(H) 9925 -0.876 Decreased triglyceride expression no Adiposity regulation (4) Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Pospisilik et al. 2010 20074523 Tissue oe-GAL4 Total fly triglyceride expression Colorimetrics np Selected genes UAS-IR construct Triglyceride change > 0.25 OR <-0.25 (change >25%) Additional information about the primary screen
GR00190-A-5 34881 FBgn0004837 Su(H) 9925 -0.714 Decreased triglyceride expression no Adiposity regulation (5) Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Pospisilik et al. 2010 20074523 Tissue ppl-GAL4 Total fly triglyceride expression Colorimetrics np Selected genes UAS-IR construct Triglyceride change > 0.25 OR <-0.25 (change >25%) Additional information about the primary screen
GR00218-S 34881 CG3497 Su(H) AMB19826 -0.91 none no Hippo pathway regulation Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila Wehr et al. 2013 23263283 Cell line S2R+ Hippo pathway reporter Luminescence np Genome-wide dsRNA Z-score > 3 OR < -3 Author-submitted data. Primary screen
GR00239-A-1 34881 CG3497 3497R sp none no Glycosylation regulation (1) Identification of genes required for neural-specific glycosylation using functional genomics. Yamamoto-Hino et al. 2010 21203496 Tissue GMR-GAL4 Chaoptin (Chp) protein expression, alpha1,3-fucose, alpha1,6-fucose, (GlcNAc)n, GlcNAcb1-4GlcNAc and mannose Chp glycosylation and viability Luminescence np Selected genes UAS-IR construct Z-score > 3
GR00282-A 34881 CG3497 Su(H) 103597 np none piRNA pathway regulation The Genetic Makeup of the Drosophila piRNA Pathway Handler 2013 23665231 Tissue tj-GAL4 Gypsy transposon expression Microscopy VDRC Selected genes UAS-IR construct Visual inspection np See comment for ovarian morphology data. Gene expression data shown in the comment derive from an ovarian stem cell line. VDRC library: KK and GD used, see phenotype data
GR00284-A 34881 CG3497 Su(H) 103597 -0.04362370440853165 none piRNA pathway regulation A Transcriptome-wide RNAi Screen in the Drosophila Ovary Reveals Factors of the Germline piRNA Pathway Czech et al. 2013 23665227 Tissue nos-GAL4 Transposon expression qPCR VDRC Selected genes UAS-IR construct Z-score Weak < -1.5; strong: < -2 KK and GD libraries used (see phenotype data)
GR00311-A 34881 FBgn0004837 Su(H) DRSC03445 np none Actin and microtubule morphology Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype Rohn et al. 2011 21893601 Cell line S2R+ Alpha-tubulin and F-actin protein expression Fluorescence DRSC Genome-wide dsRNA Visual inspection np Exact phenotypes are shown in the comment section. Several genes were indicated as hits but no phenotype was provided. The screen data plus images is available at http://jcb-dataviewer.rupress.org/jcb/browse/4609/S2.
GR00315-A-1 34881 CG3497 Su(H) 103597 np none Follicular epithelium development (1) A genome-scale in vivo RNAi analysis of epithelial development in Drosophila identifies new proliferation domains outside of the stem cell niche Berns et al. 2014 24762813 Tissue Escargot-GAL4 and GR1-GAL4, GR1-GAL4, traffic jam-GAL4 Follicular epithelium morphology Fluorescence VDRC KK Random genes UAS-IR construct Visual inspection np Further classification screen available, see follicular epithelium development (2).
GR00335-A 34881 FBgn0004837 Su(H) HM05110 np none Germline stem cell (GSC) regulation A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal Yan et al. 2014 24576427 Tissue MTD-GAL4 or UAS-dcr2; nanos-GAL4 Spectrin and vasa protein expression Fluorescence TRiP Selected genes UAS-IR construct Visual inspection np More detailed phenotypes for some genes are shown in the comment. Various VALIUM vectors were used.
34881 FBgn0004837 np np sp none
GR00367-S 34881 CG3497 103597 np none VDRC Drosophila airway maturation Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes Hosono et al. 2015 26551273 Tissue btl-GAL4 Liquid clearance defect and viability Visual inspection VDRC, Trip, NIG Genome-wide UAS-IR construct Frequency >30%
GR00379-A-1 34881 CG3497 103597 -0.15695146366145823 none No phenotype in egg laying/hatching or larvae in egg laying or larvae Stem cell maintenance Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation Sanchez et al. 2016 26669894 Organism nanos-GAL4 nos and yTub37c mRNA expression qPCR VDRC Selected genes UAS-IR construct Z-score Low: 1 - 2.5; Medium: 2.5 - 4; High: > Selected genes are: transcriptome-wide in female Drosophila. Additional phenotypes (egg laying/hatching) noted in the comment section. Subset libraries from VDRC (KK or GD) can be found in a column next to the comment field.
GR00385-A 34881 103597 0.19 Low performer in olfactory memory formation Final hit Regulation of olfactory memory formation Identification of genes that promote or inhibit olfactory memory formation in Drosophila. Walkinshaw et al. 2015 25644700 Organism Nsyb-GAL4 T-maze performance Visual inspection VDRC Selected genes UAS-IR construct Performance index, sp High performer in olfactory memory formation: > Genes were preselected for relevance to CNS development and function using bioinformatic criteria. Additionally, defects in wing formation are considered in the comments column. We could not confirm the exact number of primary hits; however, final hits are noted in the comments field.
GR00388-A 34881 CG3497 BL28900 Lethal Regulation of intestinal stem cells (ISC) Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila Zeng et al. 2015 25704823 Tissue act5C-GAL4 Viability Visual inspection VDRC and BDSC Genome-wide UAS-IR construct np np Lethal transgenic lines identified from the primary screen were crossed with temperature-sensitive esg-GAL4 flies. Phenotypes of ISCs from the dissected midguts are shown in the "Comment" section.
GR00388-A 34881 CG3497 KK103597 Lethal Regulation of intestinal stem cells (ISC) Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila Zeng et al. 2015 25704823 Tissue act5C-GAL4 Viability Visual inspection VDRC and BDSC Genome-wide UAS-IR construct np np Lethal transgenic lines identified from the primary screen were crossed with temperature-sensitive esg-GAL4 flies. Phenotypes of ISCs from the dissected midguts are shown in the "Comment" section.
GR00388-A 34881 CG3497 GD9925 none Regulation of intestinal stem cells (ISC) Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila Zeng et al. 2015 25704823 Tissue act5C-GAL4 Viability Visual inspection VDRC and BDSC Genome-wide UAS-IR construct np np Lethal transgenic lines identified from the primary screen were crossed with temperature-sensitive esg-GAL4 flies. Phenotypes of ISCs from the dissected midguts are shown in the "Comment" section.