RNAi

Gene Info

  • Species: Fly (Drosophila melanogaster)
  • GeneID: 36001
  • Symbol: dap
  • Description: dacapo
DataSource: http://genomernai.dkfz.de/v16/genedetails/36001

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Stable_ID Entrez_ID Gene_ID Gene_Symbol Reagent_ID Score Phenotype Conditions Follow_Up Comment Screen_Title Publication_Title Authors Publication_Year Pubmed_ID Biosource Biomodel Assay Method Library Scope Reagent_Type Score_Type Cutoff Notes
GR00002-A 36001 FBgn0010316 dap DRSC07601 0.54042683 none no Lipid storage COPI complex is a regulator of lipid homeostasis. Beller et al. 2008 19067489 Cell line Kc167 Nuclear to lipid droplet cross-sectional area Fluorescence np Genome-wide dsRNA B-score > 2 OR < -1.7 Additional information about a secondary screen with non-overlaping dsRNAs
GR00002-A 36001 FBgn0010316 dap DRSC07601 1.089098656 none no Lipid storage COPI complex is a regulator of lipid homeostasis. Beller et al. 2008 19067489 Cell line Kc167 Nuclear to lipid droplet cross-sectional area Fluorescence np Genome-wide dsRNA B-score > 2 OR < -1.7 Additional information about a secondary screen with non-overlaping dsRNAs
GR00007-A-0 36001 FBgn0010316 DRSC07601 np Lamellar structures no Neural outgrowth Identification of neural outgrowth genes using genome-wide RNAi. Sepp et al. 2008 18604272 Cell line Primary neural cells Morphology High content (microscopy) DRSC dsRNA Visual inspection np
GR00031-A-1 36001 HFA07601 -0.1 none yes Cell growth and viability (1) Genome-wide RNAi analysis of growth and viability in Drosophila cells. Boutros et al. 2004 14764878 Cell line Kc167 Cell number and viability Luminescence Custom-made (HFA) Genome-wide dsRNA Z-score >
GR00031-A-2 36001 HFA07601 -0.4 none no Cell growth and viability (2) Genome-wide RNAi analysis of growth and viability in Drosophila cells. Boutros et al. 2004 14764878 Cell line S2R+ Cell number and viability Luminescence Custom-made (HFA) Genome-wide dsRNA Z-score >
36001 FBgn0010316 dap LP07247 sp none no library: DGC1
GR00148-A 36001 FBgn0010316 dap np 2.87 Increased P-JNK protein expression with PGN 15 min PGN induction no PGN-induced dJNK phosphorylation A quantitative RNAi screen for JNK modifiers identifies Pvr as a novel regulator of Drosophila immune signaling. Bond and Foley 2009 19893628 Cell line S2 P-JNK protein expression Fluorescence Custom-made Genome-wide dsRNA Z-score Complex criteria Only hits stored in GenomeRNAi
GR00202-A 36001 FBgn0010316 dap np sp none no Vaccinia virus infection A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. Moser et al. 2010 20585561 Cell line DL1 Virally encoded beta-galactosidase protein expression Fluorescence Custom-made Kinases, phosphatases and selected genes dsRNA Z-score < -2 in both duplicates Author-reviewed data
GR00218-S 36001 CG1772 dap AMB29074 -1.24 none no Hippo pathway regulation Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila Wehr et al. 2013 23263283 Cell line S2R+ Hippo pathway reporter Luminescence np Genome-wide dsRNA Z-score > 3 OR < -3 Author-submitted data. Primary screen
GR00311-A 36001 FBgn0010316 dap DRSC07601 np none Actin and microtubule morphology Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype Rohn et al. 2011 21893601 Cell line S2R+ Alpha-tubulin and F-actin protein expression Fluorescence DRSC Genome-wide dsRNA Visual inspection np Exact phenotypes are shown in the comment section. Several genes were indicated as hits but no phenotype was provided. The screen data plus images is available at http://jcb-dataviewer.rupress.org/jcb/browse/4609/S2.
36001 np np HFA07601 -0.61 none fold change: 1.77
36001 FBgn0010316 np np sp none
GR00370-A 36001 FBgn0010316 dap -1.68 Decreased CncC (Nrf2) reporter expression Regulation of Nrf2 homolog CncC Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes Li et al. 2016 26911346 Cell line S2 CncC reporter Luminescence HD2 Kinases dsRNA Z-Score <-1.65 OR >1.65
GR00370-A 36001 FBgn0010316 dap 0.18 none Regulation of Nrf2 homolog CncC Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes Li et al. 2016 26911346 Cell line S2 CncC reporter Luminescence HD2 Kinases dsRNA Z-Score <-1.65 OR >1.65
GR00370-A 36001 FBgn0010316 dap -1.14 none Regulation of Nrf2 homolog CncC Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes Li et al. 2016 26911346 Cell line S2 CncC reporter Luminescence HD2 Kinases dsRNA Z-Score <-1.65 OR >1.65