RNAi

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 10413
  • Symbol: YAP1
  • Description: Yes1 associated transcriptional regulator
DataSource: http://genomernai.dkfz.de/v16/genedetails/10413

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Stable_ID Entrez_ID Gene_ID Gene_Symbol Reagent_ID Score Phenotype Conditions Follow_Up Comment Screen_Title Publication_Title Authors Publication_Year Pubmed_ID Biosource Biomodel Assay Method Library Scope Reagent_Type Score_Type Cutoff Notes
GR00016-A 10413 YAP np 6.31 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation no Wnt/beta-catenin pathway regulation Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. James et al. 2009 19471023 Cell line RKO Wnt/beta-catenin pathway reporter Luminescence rp Selected genes siRNA Z-score > 2
GR00053-A 10413 NM_006106 YAP1 np sp none no Genome stability A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Paulsen et al. 2009 19647519 Cell line HeLa gamma-H2AX phosphorylation and DNA content Fluorescence siARRAY human genome siRNA library Genome-wide siRNA p-value Complex criteria Confidence groupings from 4 to 1 (highest level of confidence in group 4)
GR00054-A 10413 NM_006106 YAP1 np 1.337 none no Combinatorial effect with paclitaxel Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Whitehurst et al. 2007 17429401 Cell line NCI-H1155 Viability (synthetic lethal) ATP level # G-005000-01 Genome-wide siRNA Paclitaxel/control ratio Complex criteria Additional information about 87 high-confidence hits
GR00056-A 10413 NM_006106 YAP1 np 0.924 none no Melanogenesis Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. Ganesan et al. 2008 19057677 Cell line MNT-1 Melanin protein expression and viability Absorbance and luminescence rp Genome-wide siRNA Normalized absorbance ratio > 2 standard deviations below mean Additional information about a secondary screen (retest to determine false-positive rate)
GR00057-A-1 10413 NM_006106 YAP1 M-012200-00 -0.21 none no Wnt/beta-catenin pathway regulation (1) A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Tang et al. 2008 18621708 Cell line HeLa Wnt pathway reporter Luminescence Human siArray siRNA library Genome-wide siRNA Z-score > 4 Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00057-A-2 10413 NM_006106 YAP1 M-012200-00 sp none no Wnt/beta-catenin pathway regulation (2) A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Tang et al. 2008 18621708 Cell line HeLa Wnt pathway reporter Luminescence Human siArray siRNA library Genome-wide siRNA Complex, SP Complex criteria Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00095-A 10413 NM_006106 YAP1 np np none p53 pathway components A large-scale RNAi screen in human cells identifies new components of the p53 pathway Berns et al. 2004 15042092 Cell line BJ-TERT-tsLT fibroblasts Proliferation Colony-forming cell assay Nki library Genome-wide shRNA np np
GR00098-A-1 10413 ENSG00000137693 YAP1 ENSG00000137693 sp none no Cell division (1) Genome-scale RNAi profiling of cell division in human tissue culture cells. Kittler et al. 2007 17994010 Cell line HeLa Cell number and DNA content Laser scanning cytometry rp Genome-wide esiRNA Complex, sp Complex criteria
GR00123-A 10413 NM_006106 YAP1 134461, 134462, 134463 np none Combinatorial effect with nutlin-3 An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors Brummelkamp et al. 2006 16474381 Cell line MCF-7 Viability Fluoresence Nki library Genome-wide shRNA log2 ratio np
GR00133-A-1 10413 10413 YAP1 np -0.087627 none no Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Misselwitz et al. 2011 21407211 Cell line HeLa Gentamycin protection invasion assay Fluorescence Druggable genome library V2.0 Druggable genes siRNA log2 median Complex criteria
GR00151-A-1 10413 ENSG00000137693 YAP1 np -0.581 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (1) A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. SÅ‚abicki et al. 2010 20613862 Cell line HeLa (HR-DSBR) DR-GFP reporter Flow cytometry Custom-made Genome-wide esiRNA Z-score < -2 OR > 2
GR00180-A-1 10413 10413 YAP1 PL-50008 0.881 none no Hepatitis C virus replication (1) A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Tai et al. 2009 19286138 Cell line Huh7/Rep-Feo HCV replicon RNA copy number Luminescence siARRAY Human Genome siRNA Library Genome-wide siRNA q-value Complex criteria
GR00184-A-1 10413 NM_006106 YAP1 M-012200-00 -4.25641494250733 Decreased POU5F1-GFP protein expression yes Self-renewal and pluripotency in human embryonic stem cells (1) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 POU5F1 protein expression Fluorescence SMARTpool siRNA library Genome-wide siRNA Z-score < -2
GR00184-A-2 10413 NM_006106 YAP1 D-012200-01 0.661156379112278 Decreased OCT4 protein expression yes Self-renewal and pluripotency in human embryonic stem cells (2) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 OCT4 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-2 10413 NM_006106 YAP1 D-012200-04 0.786172212199779 none yes Self-renewal and pluripotency in human embryonic stem cells (2) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 OCT4 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-2 10413 NM_006106 YAP1 D-012200-02 0.61568253455102 Decreased OCT4 protein expression yes Self-renewal and pluripotency in human embryonic stem cells (2) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 OCT4 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-2 10413 NM_006106 YAP1 D-012200-03 0.41332557635685 Decreased OCT4 protein expression yes Self-renewal and pluripotency in human embryonic stem cells (2) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 OCT4 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-3 10413 NM_006106 YAP1 D-012200-04 0.946260891651504 none yes Self-renewal and pluripotency in human embryonic stem cells (3) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 NANOG protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-3 10413 NM_006106 YAP1 D-012200-01 1.18668571162573 none yes Self-renewal and pluripotency in human embryonic stem cells (3) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 NANOG protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-3 10413 NM_006106 YAP1 D-012200-03 0.849770703963653 none yes Self-renewal and pluripotency in human embryonic stem cells (3) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 NANOG protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-3 10413 NM_006106 YAP1 D-012200-02 1.25363418331441 none yes Self-renewal and pluripotency in human embryonic stem cells (3) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 NANOG protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-4 10413 NM_006106 YAP1 D-012200-03 0.367696380194743 Decreased POU5F1-GFP protein expression yes Self-renewal and pluripotency in human embryonic stem cells (4) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 POU5F1 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-4 10413 NM_006106 YAP1 D-012200-01 0.646621971098162 Decreased POU5F1-GFP protein expression yes Self-renewal and pluripotency in human embryonic stem cells (4) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 POU5F1 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-4 10413 NM_006106 YAP1 D-012200-04 0.662819270580034 Decreased POU5F1-GFP protein expression yes Self-renewal and pluripotency in human embryonic stem cells (4) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 POU5F1 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-4 10413 NM_006106 YAP1 D-012200-02 0.692047674568463 Decreased POU5F1-GFP protein expression yes Self-renewal and pluripotency in human embryonic stem cells (4) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 POU5F1 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-5 10413 NM_006106 YAP1 D-012200-03 0.572411123820626 Decreased OCT4 protein expression yes Self-renewal and pluripotency in human embryonic stem cells (5) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES2 OCT4 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-5 10413 NM_006106 YAP1 D-012200-02 0.764982879344222 none yes Self-renewal and pluripotency in human embryonic stem cells (5) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES2 OCT4 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-5 10413 NM_006106 YAP1 D-012200-04 0.782494632609568 none yes Self-renewal and pluripotency in human embryonic stem cells (5) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES2 OCT4 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-5 10413 NM_006106 YAP1 D-012200-01 1.15054131652508 none yes Self-renewal and pluripotency in human embryonic stem cells (5) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES2 OCT4 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-6 10413 NM_006106 YAP1 D-012200-01 0.853264804087373 none yes Self-renewal and pluripotency in human embryonic stem cells (6) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES2 NANOG protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-6 10413 NM_006106 YAP1 D-012200-04 0.763807452954319 none yes Self-renewal and pluripotency in human embryonic stem cells (6) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES2 NANOG protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-6 10413 NM_006106 YAP1 D-012200-03 0.506518388403634 Decreased NANOG protein expression yes Self-renewal and pluripotency in human embryonic stem cells (6) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES2 NANOG protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-6 10413 NM_006106 YAP1 D-012200-02 0.578649259551847 Decreased NANOG protein expression yes Self-renewal and pluripotency in human embryonic stem cells (6) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES2 NANOG protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-7 10413 NM_006106 YAP1 D-012200-04 2.35533622427604 none yes Self-renewal and pluripotency in human embryonic stem cells (7) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES3 OCT4 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-7 10413 NM_006106 YAP1 D-012200-02 1.58038668912365 none yes Self-renewal and pluripotency in human embryonic stem cells (7) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES3 OCT4 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-7 10413 NM_006106 YAP1 D-012200-01 1.98466029162159 none yes Self-renewal and pluripotency in human embryonic stem cells (7) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES3 OCT4 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-7 10413 NM_006106 YAP1 D-012200-03 1.99978494708555 none yes Self-renewal and pluripotency in human embryonic stem cells (7) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES3 OCT4 protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-8 10413 NM_006106 YAP1 D-012200-01 1.50899128669347 none yes Self-renewal and pluripotency in human embryonic stem cells (8) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES3 NANOG protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-8 10413 NM_006106 YAP1 D-012200-03 1.5570398893269 none yes Self-renewal and pluripotency in human embryonic stem cells (8) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES3 NANOG protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-8 10413 NM_006106 YAP1 D-012200-04 1.94625963696242 none yes Self-renewal and pluripotency in human embryonic stem cells (8) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES3 NANOG protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00184-A-8 10413 NM_006106 YAP1 D-012200-02 1.26606160295119 none yes Self-renewal and pluripotency in human embryonic stem cells (8) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line HES3 NANOG protein expression Fluorescence siGENOME siRNA library Selected genes siRNA Relative expression < 0.75
GR00196-A-1 10413 ENSG00000137693 np sp Decreased viability of wild-type and TP53 knockout cells no viability Z-score < -1.5 TP53 interactions (1) A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. Krastev et al. 2011 21642980 Cell line HCT116 ( wildtype and TP53 knockout) TP53 protein expression and viability Fluorescence rp Genome-wide esiRNA Complex, sp Complex criteria
GR00197-A-1 10413 10413 YAP1 M-012200-00 -0.6842269 none no Human papillomavirus oncogene expression regulation (1) Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Smith et al. 2010 20133580 Cell line C33A/BE2/18LCR c4 HPV18 LCR reporter activity Luminescence Human siGENOME SMARTpool library Genome-wide siRNA Z-score > Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5
GR00232-A-1 10413 NM_006106 YAP1 v2HS_247011 1.60807268866667 Decreased ionizing radiation sensitivity no DNA damage regulation after ionizing radiation (1) A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Hurov et al. 2010 20810650 Cell line U2OS Ionizing radiation sensitivity Fluorescence pSMP Genome-wide shRNA log2 mean ratio < -1 OR > 1 The shRNA library is in a MSCV-PURO-based vector (MSCV-PM; Open Biosystems nomenclature is pSMP). The shRNAs with the “V3LHS” identifier were subcloned into the MSCV-PM vector from the pGIPZ vector. Additional information about a secondary screen in H460 cells.
GR00232-A-1 10413 NM_006106 YAP1 v2HS_65509 1.43632247433333 Decreased ionizing radiation sensitivity no DNA damage regulation after ionizing radiation (1) A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Hurov et al. 2010 20810650 Cell line U2OS Ionizing radiation sensitivity Fluorescence pSMP Genome-wide shRNA log2 mean ratio < -1 OR > 1 The shRNA library is in a MSCV-PURO-based vector (MSCV-PM; Open Biosystems nomenclature is pSMP). The shRNAs with the “V3LHS” identifier were subcloned into the MSCV-PM vector from the pGIPZ vector. Additional information about a secondary screen in H460 cells.
10413 YAP1 np np Decreased viability in colon lineage no colon: no filter, two analyses
GR00236-A-1 10413 10413 YAP1 M-012200-00 1.46332623035075 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (1) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Adamson et al. 2012 22344029 Cell line DR-U2OS (HR-DSBR) DR-GFP reporter and DNA content Fluorescence Human siGENOME siRNA (G-005000-05) Genome-wide siRNA Relative HR ratio < ~0.4 OR > 1.88 Cutoff values correspond 2 standard deviations from the screen-wide mean
GR00240-S-1 10413 NM_006106 YAP1 M-012200-00 -1 none yes TRAIL-induced apoptosis (1) A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. Kranz and Boutros 2014 24442637 Cell line U251MG Viability Luminescence SMART-pool siRNA Genome-wide siRNA Z-score > 4 Author-submitted data
GR00240-S-2 10413 NM_006106 YAP1 M-012200-00 0.01 none no Z-score -0.852 TRAIL-induced apoptosis (2) A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. Kranz and Boutros 2014 24442637 Cell line U251MG Viability (synthetic lethal) Luminescence SMART-pool siRNA Genome-wide siRNA Differential score > 3.6 AND viability Z-score < 4 Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen.
GR00242-A-1 10413 NM_006106 YAP1 np sp none no Selective autophagy regulation (1) Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl et al. 2011 22020285 Cell line HeLa/GFP-LC3 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression Fluorescence siGenome Genome-wide siRNA Z-score Complex criteria
GR00247-A-1 10413 YAP1 np sp none rank: 12815 Regulation of FOXO1 nuclear localization (1) Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Senapedis et al. 2011 21460183 Cell line U2OS EGFP-FOXO1a protein expression and DNA content Fluorescence Human Genome library Genome-wide siRNA Complex, sp Complex criteria
GR00249-S 10413 10413 YAP1 J-012200-05 0.70349 none no number of cells compared to control (%): 91.37 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 10413 10413 YAP1 M-012200-00 -0.36612 Decreased viability no number of cells compared to control (%): 45.98 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 10413 10413 YAP1 s20366 -0.93219 none no number of cells compared to control (%): 80.05 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 10413 10413 YAP1 s20367 -1.21636 none no number of cells compared to control (%): 80.61 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 10413 10413 YAP1 s20368 -0.52546 none no number of cells compared to control (%): 92.05 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00253-A 10413 NM_006106 YAP1 np 0.328 none hepcidin regulation Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Mleczko-Sanecka et al. 2014 24385536 Cell line Huh7 hepcidin::fluc mRNA expression Luminescence siGenome siARRAY SMARTpool Genome-wide siRNA Z-score > Cutoff <
GR00255-A-1 10413 10413 YAP1 TRCN0000107265, TRCN0000107266, TRCN0000107267, TRCN0000107268, TRCN0000107269 0.364408775 none Negative genetic interactions (1) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-2 10413 10413 YAP1 TRCN0000107265, TRCN0000107266, TRCN0000107267, TRCN0000107268, TRCN0000107269 -0.771743339 none Negative genetic interactions (2) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-3 10413 10413 YAP1 TRCN0000107265, TRCN0000107266, TRCN0000107267, TRCN0000107268, TRCN0000107269 0.715235074 none Negative genetic interactions (3) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-4 10413 10413 YAP1 TRCN0000107265, TRCN0000107266, TRCN0000107267, TRCN0000107268, TRCN0000107269 -1.024844531 none Negative genetic interactions (4) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-5 10413 10413 YAP1 TRCN0000107265, TRCN0000107266, TRCN0000107267, TRCN0000107268, TRCN0000107269 1.045726314 none Negative genetic interactions (5) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -0.8 HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00293-A 10413 YAP np -0.043 none Combinatorial effect with paclitaxel Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death Sinnott et al. 2014 24860162 Cell line HCC366 Viability Luminescence Thermo-Fisher Genome-wide siRNA Z-score < -2.5 Final hits according to the author are indicated in the comment.
GR00293-A 10413 YAP1 np -0.222 none Combinatorial effect with paclitaxel Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death Sinnott et al. 2014 24860162 Cell line HCC366 Viability Luminescence Thermo-Fisher Genome-wide siRNA Z-score < -2.5 Final hits according to the author are indicated in the comment.
GR00300-A 10413 YAP1 TRCN0000107269, TRCN0000107267, TRCN0000107268, TRCN0000107265, TRCN0000107266 0 none Combinatorial effect with RAF inhibitor PLX4720 A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Whittaker et al. 2013 23288408 Cell line A375 shRNA abundance Sequencing TRC Genome-wide shRNA Number of shRNAs ranked Top1000 > 2 The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors.
GR00303-A 10413 NM_006106 YAP1 np -0.82 none Clear cell renal cell carcinoma (ccRCC) survival regulation Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target Gerlinger et al. 2012 22362593 Cell line VHL-deficient RCC4 Proliferation and Viability Fluorescence np Genome-wide siRNA Z-score < In the phenotype data duplicates were in the original document, which have been removed.
GR00310-A-1 10413 10413 YAP1 np 0.08 none Sindbis virus (SINV) infection (1) Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry Ooi et al. 2013 24367265 Cell line U2OS Sindbis virus (SINV) reporter Luminescence Ambion Silencer V3 Genome-wide siRNA Z-score < -3 OR > 2
10413 10413 YAP1 np 7.8 none 84,4% viability
GR00313-A 10413 NM_006106 YAP1 np 0.71 none TNF-alpha pathway regulation A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. Nickles et al. 2012 22733992 Cell line HEK293T NFkappaB pathway reporter Luminescence Qiagen Genome-wide siRNA Z-score < Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%.
GR00318-A 10413 10413 YAP1 np 1.407 none siRNA set: druggable genome Huntingtin toxicity A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease Miller et al. 2012 23209424 Cell line HEK293T Caspase 3/7 activity Fluorescence Dharmacon Selected genes siRNA Sum of normalized caspase 3/7 activity mean and standard error < 0.683 HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP).
10413 NM_006106 YAP1 M-012200-00 np none
10413 NM_006106 YAP1 M-012200-00 2.7 Decreased infection with West Nile virus (WNV) 3.69
10413 YAP1 NM_006106 D-012200-04 2.1 Decreased West Nile virus (WNV) infection 2.4
10413 YAP1 NM_006106 D-012200-03 2 Decreased West Nile virus (WNV) infection 2.7
GR00366-A-1 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.08060291204331 none YAP1_1_1111 Context-specific genetic dependencies (1) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 22RV1_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-10 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.473993646551653 none YAP1_1_1111 Context-specific genetic dependencies (10) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ACHN_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-100 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.00046515695281908 none YAP1_1_1111 Context-specific genetic dependencies (100) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-101 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.433966729731241 none YAP1_1_1111 Context-specific genetic dependencies (101) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LK2_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-102 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.137764826657464 none YAP1_1_1111 Context-specific genetic dependencies (102) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN215_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-103 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.555341988671111 none YAP1_1_1111 Context-specific genetic dependencies (103) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN229_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-104 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.0262013703773073 none YAP1_1_1111 Context-specific genetic dependencies (104) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN235_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-105 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.529503329750742 none YAP1_1_1111 Context-specific genetic dependencies (105) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN319_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-106 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.387216953348064 none YAP1_1_1111 Context-specific genetic dependencies (106) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN340_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-107 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.709238271941966 none YAP1_1_1111 Context-specific genetic dependencies (107) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN382_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-108 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.172941999794911 none YAP1_1_1111 Context-specific genetic dependencies (108) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN428_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-109 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.0729256189540342 none YAP1_1_1111 Context-specific genetic dependencies (109) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN443_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-11 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -2.09271809099449 Decreased shRNA abundance (Z-score < -2) YAP1_1_1111 Context-specific genetic dependencies (11) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AGS_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-110 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.255533877660848 none YAP1_1_1111 Context-specific genetic dependencies (110) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN464_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-111 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.485358171021167 none YAP1_1_1111 Context-specific genetic dependencies (111) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LNZ308_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-112 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.457222277089364 none YAP1_1_1111 Context-specific genetic dependencies (112) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LOVO_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-113 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.178850602139173 none YAP1_1_1111 Context-specific genetic dependencies (113) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LS411N_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-114 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.732058856442616 none YAP1_1_1111 Context-specific genetic dependencies (114) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LS513_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-115 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.352129502293579 none YAP1_1_1111 Context-specific genetic dependencies (115) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MCF7_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-116 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.917993102395679 none YAP1_1_1111 Context-specific genetic dependencies (116) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MDAMB453_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-117 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.400886903926669 none YAP1_1_1111 Context-specific genetic dependencies (117) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MIAPACA2_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-118 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -1.19513897385647 none YAP1_1_1111 Context-specific genetic dependencies (118) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MKN7_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-119 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.791159852442532 none YAP1_1_1111 Context-specific genetic dependencies (119) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-12 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.454857096699117 none YAP1_1_1111 Context-specific genetic dependencies (12) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AM38_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-120 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.714092768678346 none YAP1_1_1111 Context-specific genetic dependencies (120) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-121 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.86138132579017 Increased shRNA abundance (Z-score > 2) YAP1_1_1111 Context-specific genetic dependencies (121) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-122 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.655501345715015 none YAP1_1_1111 Context-specific genetic dependencies (122) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-123 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.30458867593054 none YAP1_1_1111 Context-specific genetic dependencies (123) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-124 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.539435345847412 none YAP1_1_1111 Context-specific genetic dependencies (124) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-125 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.62654441646333 Increased shRNA abundance (Z-score > 2) YAP1_1_1111 Context-specific genetic dependencies (125) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-126 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.192535267043016 none YAP1_1_1111 Context-specific genetic dependencies (126) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1299_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-127 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.19571421824587 none YAP1_1_1111 Context-specific genetic dependencies (127) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1437_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-128 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.846682491605817 none YAP1_1_1111 Context-specific genetic dependencies (128) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1650_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-129 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.140698302888664 none YAP1_1_1111 Context-specific genetic dependencies (129) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1792_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-13 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.297383422948558 none YAP1_1_1111 Context-specific genetic dependencies (13) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-130 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.111853919460919 none YAP1_1_1111 Context-specific genetic dependencies (130) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH196_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-131 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.710284613897866 none YAP1_1_1111 Context-specific genetic dependencies (131) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1975_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-132 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -2.1760191362217 Decreased shRNA abundance (Z-score < -2) YAP1_1_1111 Context-specific genetic dependencies (132) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2052_PLEURA shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-133 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.225421133307899 none YAP1_1_1111 Context-specific genetic dependencies (133) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2122_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-134 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.669540045912371 none YAP1_1_1111 Context-specific genetic dependencies (134) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2171_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-135 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.167016724069184 none YAP1_1_1111 Context-specific genetic dependencies (135) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH23_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-136 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.118298543185291 none YAP1_1_1111 Context-specific genetic dependencies (136) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2452_PLEURA shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-137 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.20546641922518 none YAP1_1_1111 Context-specific genetic dependencies (137) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH441_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-138 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.974521896432719 none YAP1_1_1111 Context-specific genetic dependencies (138) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH508_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-139 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0707743766517565 none YAP1_1_1111 Context-specific genetic dependencies (139) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH660_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-14 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.635767663188836 none YAP1_1_1111 Context-specific genetic dependencies (14) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ASPC1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-140 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.418571546355014 none YAP1_1_1111 Context-specific genetic dependencies (140) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH661_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-141 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.964558763900937 none YAP1_1_1111 Context-specific genetic dependencies (141) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH716_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-142 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.265299134694193 none YAP1_1_1111 Context-specific genetic dependencies (142) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH838_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-143 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.60503254988295 none YAP1_1_1111 Context-specific genetic dependencies (143) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIN87_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-144 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.89361250842844 Increased shRNA abundance (Z-score > 2) YAP1_1_1111 Context-specific genetic dependencies (144) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NIHOVCAR3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-145 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.833574713593225 none YAP1_1_1111 Context-specific genetic dependencies (145) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-146 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.536661173773237 none YAP1_1_1111 Context-specific genetic dependencies (146) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OAW42_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-147 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.84041819683294 Increased shRNA abundance (Z-score > 2) YAP1_1_1111 Context-specific genetic dependencies (147) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-148 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.18742907427637 none YAP1_1_1111 Context-specific genetic dependencies (148) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-149 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.37934719814928 none YAP1_1_1111 Context-specific genetic dependencies (149) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-15 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -1.38924536219074 Decreased shRNA abundance (Z-score < -2) YAP1_1_1111 Context-specific genetic dependencies (15) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BT20_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-150 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.131348481519376 none YAP1_1_1111 Context-specific genetic dependencies (150) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OE33_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-151 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.753834515321523 none YAP1_1_1111 Context-specific genetic dependencies (151) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OELE_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-152 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.252153562194318 none YAP1_1_1111 Context-specific genetic dependencies (152) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-153 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.867744827044131 none YAP1_1_1111 Context-specific genetic dependencies (153) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OV7_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-154 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.547880722459329 none YAP1_1_1111 Context-specific genetic dependencies (154) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OV90_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-155 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -1.03462488830731 none YAP1_1_1111 Context-specific genetic dependencies (155) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVCAR4_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-156 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.98378269860825 none YAP1_1_1111 Context-specific genetic dependencies (156) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVCAR8_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-157 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.114578138739741 none YAP1_1_1111 Context-specific genetic dependencies (157) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVISE_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-158 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.724744994183518 none YAP1_1_1111 Context-specific genetic dependencies (158) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC0327_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-159 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.296220194961906 none YAP1_1_1111 Context-specific genetic dependencies (159) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC0813_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-16 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.563093883353868 none YAP1_1_1111 Context-specific genetic dependencies (16) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BT474_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-160 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.0398572042669223 none YAP1_1_1111 Context-specific genetic dependencies (160) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC1005_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-161 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.240547498458053 none YAP1_1_1111 Context-specific genetic dependencies (161) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-162 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.689062003764175 none YAP1_1_1111 Context-specific genetic dependencies (162) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PSN1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-163 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.586811597727152 none YAP1_1_1111 Context-specific genetic dependencies (163) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line QGP1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-164 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.784399784457195 none YAP1_1_1111 Context-specific genetic dependencies (164) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-165 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.76940514266422 none YAP1_1_1111 Context-specific genetic dependencies (165) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RKN_SOFT_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-166 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.541814358791973 none YAP1_1_1111 Context-specific genetic dependencies (166) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RKO_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-167 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.531418533891969 none YAP1_1_1111 Context-specific genetic dependencies (167) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RMGI_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-168 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -1.19285359237995 none YAP1_1_1111 Context-specific genetic dependencies (168) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RMUGS_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-169 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0531461868497559 none YAP1_1_1111 Context-specific genetic dependencies (169) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-17 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.939745159618858 none YAP1_1_1111 Context-specific genetic dependencies (17) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BXPC3_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-170 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.387402260065057 none YAP1_1_1111 Context-specific genetic dependencies (170) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RT112_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-171 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.643015266011045 none YAP1_1_1111 Context-specific genetic dependencies (171) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-172 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.152750376296806 none YAP1_1_1111 Context-specific genetic dependencies (172) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF126_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-173 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -1.55811208492966 Decreased shRNA abundance (Z-score < -2) YAP1_1_1111 Context-specific genetic dependencies (173) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF172_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-174 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.298530742377312 none YAP1_1_1111 Context-specific genetic dependencies (174) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF295_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-175 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.850364035360879 none YAP1_1_1111 Context-specific genetic dependencies (175) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF767_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-176 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.121907834508778 none YAP1_1_1111 Context-specific genetic dependencies (176) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SJSA1_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-177 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.618861564491149 none YAP1_1_1111 Context-specific genetic dependencies (177) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKCO1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-178 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.0537079186978315 none YAP1_1_1111 Context-specific genetic dependencies (178) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKMEL5_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-179 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.369496001830884 none YAP1_1_1111 Context-specific genetic dependencies (179) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-18 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.536872678045149 none YAP1_1_1111 Context-specific genetic dependencies (18) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line C2BBE1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-180 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.436242772906336 none YAP1_1_1111 Context-specific genetic dependencies (180) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-181 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.296700006419322 none YAP1_1_1111 Context-specific genetic dependencies (181) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKOV3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-182 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.137552030149878 none YAP1_1_1111 Context-specific genetic dependencies (182) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKRC20_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-183 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.243867241119336 none YAP1_1_1111 Context-specific genetic dependencies (183) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR20_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-184 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.68057245986877 none YAP1_1_1111 Context-specific genetic dependencies (184) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR21_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-185 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.432459103827206 none YAP1_1_1111 Context-specific genetic dependencies (185) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR23_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-186 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.354140088204436 none YAP1_1_1111 Context-specific genetic dependencies (186) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR24_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-187 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.554919318582401 none YAP1_1_1111 Context-specific genetic dependencies (187) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR25_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-188 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0080907631593327 none YAP1_1_1111 Context-specific genetic dependencies (188) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR26_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-189 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.215680369795167 none YAP1_1_1111 Context-specific genetic dependencies (189) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNU1105_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-19 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0354630897709342 none YAP1_1_1111 Context-specific genetic dependencies (19) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line C32_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-190 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -1.28315120263188 none YAP1_1_1111 Context-specific genetic dependencies (190) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNU840_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-191 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.321829209870811 none YAP1_1_1111 Context-specific genetic dependencies (191) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNUC1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-192 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.601703756283074 none YAP1_1_1111 Context-specific genetic dependencies (192) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNUC2A_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-193 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.240761363001684 none YAP1_1_1111 Context-specific genetic dependencies (193) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SU8686_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-194 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -1.4224148349339 Decreased shRNA abundance (Z-score < -2) YAP1_1_1111 Context-specific genetic dependencies (194) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW1417_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-195 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.502785461289817 none YAP1_1_1111 Context-specific genetic dependencies (195) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW1783_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-196 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0317969713311192 none YAP1_1_1111 Context-specific genetic dependencies (196) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW480_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-197 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.603619176220454 none YAP1_1_1111 Context-specific genetic dependencies (197) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW48_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-198 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.404836171196951 none YAP1_1_1111 Context-specific genetic dependencies (198) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line T98G_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-199 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.355320149609666 none YAP1_1_1111 Context-specific genetic dependencies (199) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TC71_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-2 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.697553819636142 none YAP1_1_1111 Context-specific genetic dependencies (2) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-20 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.86300157659046 none YAP1_1_1111 Context-specific genetic dependencies (20) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CADOES1_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-200 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.335167567043704 none YAP1_1_1111 Context-specific genetic dependencies (200) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TCCSUP_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-201 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.514417435314431 none YAP1_1_1111 Context-specific genetic dependencies (201) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE10_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-202 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.234785819470277 none YAP1_1_1111 Context-specific genetic dependencies (202) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE15_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-203 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.56237258597623 none YAP1_1_1111 Context-specific genetic dependencies (203) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE9_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-204 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.367254543507724 none YAP1_1_1111 Context-specific genetic dependencies (204) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-205 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.277784597993248 none YAP1_1_1111 Context-specific genetic dependencies (205) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TOV112D_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-206 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0510192332838016 none YAP1_1_1111 Context-specific genetic dependencies (206) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TOV21G_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-207 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.457694387102372 none YAP1_1_1111 Context-specific genetic dependencies (207) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TT_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-208 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.402408206323379 none YAP1_1_1111 Context-specific genetic dependencies (208) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TYKNU_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-209 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.752406096426634 none YAP1_1_1111 Context-specific genetic dependencies (209) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U178_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-21 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.320349420611101 none YAP1_1_1111 Context-specific genetic dependencies (21) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAL120_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-210 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.343434792164019 none YAP1_1_1111 Context-specific genetic dependencies (210) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U251MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-211 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.510417096409338 none YAP1_1_1111 Context-specific genetic dependencies (211) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U343_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-212 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0749004239791841 none YAP1_1_1111 Context-specific genetic dependencies (212) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U87MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-213 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -1.01560691984674 none YAP1_1_1111 Context-specific genetic dependencies (213) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line UOK101_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-214 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.0905848183420572 none YAP1_1_1111 Context-specific genetic dependencies (214) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line VCAP_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-215 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.488054162543674 none YAP1_1_1111 Context-specific genetic dependencies (215) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line YKG1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-216 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.808794070288228 none YAP1_1_1111 Context-specific genetic dependencies (216) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ZR7530_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-22 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.706453456029751 none YAP1_1_1111 Context-specific genetic dependencies (22) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAL51_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-23 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.0461650516318424 none YAP1_1_1111 Context-specific genetic dependencies (23) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CALU1_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-24 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.41745768809278 none YAP1_1_1111 Context-specific genetic dependencies (24) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAOV3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-25 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.434476036519814 none YAP1_1_1111 Context-specific genetic dependencies (25) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAOV4_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-26 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.196482363267068 none YAP1_1_1111 Context-specific genetic dependencies (26) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAS1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-27 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.385374834475164 none YAP1_1_1111 Context-specific genetic dependencies (27) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CFPAC1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-28 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.483510513888858 none YAP1_1_1111 Context-specific genetic dependencies (28) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CH157MN_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-29 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.909186944466465 none YAP1_1_1111 Context-specific genetic dependencies (29) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO205_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-3 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.81588939703726 none YAP1_1_1111 Context-specific genetic dependencies (3) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 786O_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-30 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.440234715988106 none YAP1_1_1111 Context-specific genetic dependencies (30) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO704_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-31 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.361763876372441 none YAP1_1_1111 Context-specific genetic dependencies (31) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO741_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-32 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.975399904046354 none YAP1_1_1111 Context-specific genetic dependencies (32) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO783_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-33 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.46124668250572 none YAP1_1_1111 Context-specific genetic dependencies (33) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CORL23_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-34 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.878807728568267 none YAP1_1_1111 Context-specific genetic dependencies (34) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV362_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-35 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.04195062810901 none YAP1_1_1111 Context-specific genetic dependencies (35) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV434_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-36 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.127624079580006 none YAP1_1_1111 Context-specific genetic dependencies (36) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV504_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-37 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -1.66153097734196 Decreased shRNA abundance (Z-score < -2) YAP1_1_1111 Context-specific genetic dependencies (37) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV644_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-38 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0950105119132886 none YAP1_1_1111 Context-specific genetic dependencies (38) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DBTRG05MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-39 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.39893746115464 none YAP1_1_1111 Context-specific genetic dependencies (39) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DKMG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-4 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.379454189141573 none YAP1_1_1111 Context-specific genetic dependencies (4) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A1207_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-40 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.688634655011873 none YAP1_1_1111 Context-specific genetic dependencies (40) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DLD1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-41 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.226261762181883 none YAP1_1_1111 Context-specific genetic dependencies (41) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFE184_ENDOMETRIUM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-42 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.667691152669499 none YAP1_1_1111 Context-specific genetic dependencies (42) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFM19_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-43 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.0888058662430919 none YAP1_1_1111 Context-specific genetic dependencies (43) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFO21_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-44 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.432931565924559 none YAP1_1_1111 Context-specific genetic dependencies (44) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFO27_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-45 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.769638792919998 none YAP1_1_1111 Context-specific genetic dependencies (45) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EW8_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-46 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.808127707453927 none YAP1_1_1111 Context-specific genetic dependencies (46) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EWS502_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-47 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.23343371811784 none YAP1_1_1111 Context-specific genetic dependencies (47) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-48 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.92641131776965 none YAP1_1_1111 Context-specific genetic dependencies (48) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line GB1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-49 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.156620370023379 none YAP1_1_1111 Context-specific genetic dependencies (49) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line GP2D_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-5 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.146610758907142 none YAP1_1_1111 Context-specific genetic dependencies (5) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A172_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-50 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.172290476637129 none YAP1_1_1111 Context-specific genetic dependencies (50) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1187_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-51 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.650647776301279 none YAP1_1_1111 Context-specific genetic dependencies (51) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1395_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-52 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.566937941491429 none YAP1_1_1111 Context-specific genetic dependencies (52) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1954_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-53 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.553597303751304 none YAP1_1_1111 Context-specific genetic dependencies (53) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC2218_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-54 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.613745805328905 none YAP1_1_1111 Context-specific genetic dependencies (54) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC2814_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-55 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.0196569037313218 none YAP1_1_1111 Context-specific genetic dependencies (55) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC364_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-56 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.439236015617449 none YAP1_1_1111 Context-specific genetic dependencies (56) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC44_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-57 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.195098985840748 none YAP1_1_1111 Context-specific genetic dependencies (57) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC70_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-58 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.187424276308179 none YAP1_1_1111 Context-specific genetic dependencies (58) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC827GR5_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-59 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0331721566340002 none YAP1_1_1111 Context-specific genetic dependencies (59) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC827_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-6 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.02057478185284 none YAP1_1_1111 Context-specific genetic dependencies (6) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A204_SOFT_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-60 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.0044708187054 none YAP1_1_1111 Context-specific genetic dependencies (60) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCT116_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-61 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.462905461166248 none YAP1_1_1111 Context-specific genetic dependencies (61) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HEC1A_ENDOMETRIUM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-62 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.453193370510777 none YAP1_1_1111 Context-specific genetic dependencies (62) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HEYA8_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-63 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.583602145870434 none YAP1_1_1111 Context-specific genetic dependencies (63) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-64 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.278272792556169 none YAP1_1_1111 Context-specific genetic dependencies (64) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HLF_LIVER shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-65 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.220167475595046 none YAP1_1_1111 Context-specific genetic dependencies (65) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-66 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.0340615175977842 none YAP1_1_1111 Context-specific genetic dependencies (66) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HPAC_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-67 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.39822584229376 none YAP1_1_1111 Context-specific genetic dependencies (67) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HPAFII_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-68 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.261291736909962 none YAP1_1_1111 Context-specific genetic dependencies (68) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS683_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-69 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.33892501211759 none YAP1_1_1111 Context-specific genetic dependencies (69) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS766T_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-7 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0362514081124629 none YAP1_1_1111 Context-specific genetic dependencies (7) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A2058_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-70 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.622016556240656 none YAP1_1_1111 Context-specific genetic dependencies (70) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS944T_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-71 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.185151238491627 none YAP1_1_1111 Context-specific genetic dependencies (71) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT1197_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-72 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -1.74696876572031 Decreased shRNA abundance (Z-score < -2) YAP1_1_1111 Context-specific genetic dependencies (72) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT29_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-73 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -1.56340239823622 Decreased shRNA abundance (Z-score < -2) YAP1_1_1111 Context-specific genetic dependencies (73) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT55_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-74 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.150581928393506 none YAP1_1_1111 Context-specific genetic dependencies (74) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HUG1N_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-75 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.974325839081388 none YAP1_1_1111 Context-specific genetic dependencies (75) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HUTU80_SMALL_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-76 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.00319196629639735 none YAP1_1_1111 Context-specific genetic dependencies (76) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IGR39_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-77 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0430221645136502 none YAP1_1_1111 Context-specific genetic dependencies (77) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IGROV1_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-78 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.494131038888656 none YAP1_1_1111 Context-specific genetic dependencies (78) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IOMMLEE_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-79 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.247634091376934 none YAP1_1_1111 Context-specific genetic dependencies (79) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHESOAD1_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-8 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.631906166981743 none YAP1_1_1111 Context-specific genetic dependencies (8) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A549_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-80 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.282363812101887 none YAP1_1_1111 Context-specific genetic dependencies (80) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHOC5_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-81 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.264754482820961 none YAP1_1_1111 Context-specific genetic dependencies (81) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHOM1_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-82 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.694807016577915 none YAP1_1_1111 Context-specific genetic dependencies (82) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-83 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.683880312519889 none YAP1_1_1111 Context-specific genetic dependencies (83) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-84 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.924644852673625 none YAP1_1_1111 Context-specific genetic dependencies (84) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KALS1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-85 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.477676756050981 none YAP1_1_1111 Context-specific genetic dependencies (85) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-86 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.498606960684028 none YAP1_1_1111 Context-specific genetic dependencies (86) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KM12_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-87 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0637314652397916 none YAP1_1_1111 Context-specific genetic dependencies (87) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-88 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.278156807363161 none YAP1_1_1111 Context-specific genetic dependencies (88) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KNS60_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-89 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.879627062470573 none YAP1_1_1111 Context-specific genetic dependencies (89) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KNS81_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-9 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.07227488071518 none YAP1_1_1111 Context-specific genetic dependencies (9) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A673_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-90 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.309344579693743 none YAP1_1_1111 Context-specific genetic dependencies (90) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP1NL_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-91 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0936560578082699 none YAP1_1_1111 Context-specific genetic dependencies (91) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP2_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-92 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.394599136211725 none YAP1_1_1111 Context-specific genetic dependencies (92) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP4_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-93 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.587937741979743 none YAP1_1_1111 Context-specific genetic dependencies (93) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KURAMOCHI_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-94 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.638840641674021 none YAP1_1_1111 Context-specific genetic dependencies (94) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE150_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-95 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0212033916462176 none YAP1_1_1111 Context-specific genetic dependencies (95) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE30_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-96 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.199625787735757 none YAP1_1_1111 Context-specific genetic dependencies (96) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE450_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-97 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 0.0251504138621589 none YAP1_1_1111 Context-specific genetic dependencies (97) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE510_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-98 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 -0.325340090553661 none YAP1_1_1111 Context-specific genetic dependencies (98) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line L33_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-99 10413 YAP1 TRCN0000107269, TRCN0000300282, TRCN0000300325, TRCN0000310615 1.18031546291905 none YAP1_1_1111 Context-specific genetic dependencies (99) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
10413 10413 YAP1 -0.03 none
GR00371-A-1 10413 10413 YAP1 -2.19640621284 none Ambion Nanog expression in absence of bFGF and TGFbeta Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-2 10413 YAP1 10413 -0.841813164187 none Ambion Nanog expression in presence of TGFbeta inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-3 10413 10413 YAP1 -0.571908350646 none Ambion Nanog expression in presence of MEK inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-4 10413 10413 YAP1 -1.86665289354 none Ambion Nanog expression in presence of PI3K inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-5 10413 10413 YAP1 -0.630334818999 none Ambion Nanog expression in presence of retinoic acid Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00376-A-1 10413 10413 YAP1 2.6231E-5 Increased viability with SS1P at EC90 Mitigators of SS1P-induced immunotoxicity Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity Pasetto et al. 2015 25713356 Cell line KB cells Viability Luminescence Ambion Silencer Select Version 4 Genome-wide siRNA RSA P-value <0.001 SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID
GR00376-A-2 10413 10413 YAP1 0.915340406 none Sensitizers of SS1P-induced immunotoxicity Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity Pasetto et al. 2015 25713356 Cell line KB cells Viability Luminescence Ambion Silencer Select Version 4 Genome-wide siRNA RSA P-value <0.001 SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID
GR00378-A 10413 YAP1 -1.385217983 none Poliovirus vaccine production Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game van der Sanden et al. 2015 26581994 Cell line HEp-2C Infection with Attenuated Poliovirus ELISA Dharmacon Genome-wide siRNA Z-score > For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol
GR00378-A 10413 YAP -1.319296528 none Poliovirus vaccine production Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game van der Sanden et al. 2015 26581994 Cell line HEp-2C Infection with Attenuated Poliovirus ELISA Dharmacon Genome-wide siRNA Z-score > For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol
10413 NM_006106 YAP1 32.882 none
GR00386-A-1 10413 10413 YAP1 77.3549460211564 none NOD2 stimulation by MDP A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. Warner et al. 2014 25170077 Cell line HEK293 stably expressing NOD2 Viability Luminescence Dharmacon Genome-wide siRNA Percentage growth Decreased: <70, increased: >120 Reagent IDs not provided
GR00386-A-2 10413 10413 YAP1 -103.9 none MDP-induced IL-8 secretion A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. Warner et al. 2014 25170077 Cell line HEK293 stably expressing NOD2 IL-8 secretion ELISA Dharmacon Genome-wide siRNA Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided