RNAi

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 23139
  • Symbol: MAST2
  • Description: microtubule associated serine/threonine kinase 2
DataSource: http://genomernai.dkfz.de/v16/genedetails/23139

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Stable_ID Entrez_ID Gene_ID Gene_Symbol Reagent_ID Score Phenotype Conditions Follow_Up Comment Screen_Title Publication_Title Authors Publication_Year Pubmed_ID Biosource Biomodel Assay Method Library Scope Reagent_Type Score_Type Cutoff Notes
GR00016-A 23139 23139 MAST2 np 1.78 none no Wnt/beta-catenin pathway regulation Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. James et al. 2009 19471023 Cell line RKO Wnt/beta-catenin pathway reporter Luminescence rp Selected genes siRNA Z-score > 2
GR00053-A 23139 NM_015112 MAST2 np sp none no Genome stability A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Paulsen et al. 2009 19647519 Cell line HeLa gamma-H2AX phosphorylation and DNA content Fluorescence siARRAY human genome siRNA library Genome-wide siRNA p-value Complex criteria Confidence groupings from 4 to 1 (highest level of confidence in group 4)
GR00054-A 23139 NM_015112 MAST2 np 1.161 none no Combinatorial effect with paclitaxel Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Whitehurst et al. 2007 17429401 Cell line NCI-H1155 Viability (synthetic lethal) ATP level # G-005000-01 Genome-wide siRNA Paclitaxel/control ratio Complex criteria Additional information about 87 high-confidence hits
23139 23139 MAST2 np np none no
GR00056-A 23139 NM_015112 MAST2 np 1.265 none no Melanogenesis Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. Ganesan et al. 2008 19057677 Cell line MNT-1 Melanin protein expression and viability Absorbance and luminescence rp Genome-wide siRNA Normalized absorbance ratio > 2 standard deviations below mean Additional information about a secondary screen (retest to determine false-positive rate)
GR00057-A-1 23139 NM_015112 MAST2 M-004633-00 -0.37 none no Wnt/beta-catenin pathway regulation (1) A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Tang et al. 2008 18621708 Cell line HeLa Wnt pathway reporter Luminescence Human siArray siRNA library Genome-wide siRNA Z-score > 4 Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00057-A-2 23139 NM_015112 MAST2 M-004633-00 sp none no Wnt/beta-catenin pathway regulation (2) A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Tang et al. 2008 18621708 Cell line HeLa Wnt pathway reporter Luminescence Human siArray siRNA library Genome-wide siRNA Complex, SP Complex criteria Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00095-A 23139 NM_015112 MAST205 np np none p53 pathway components A large-scale RNAi screen in human cells identifies new components of the p53 pathway Berns et al. 2004 15042092 Cell line BJ-TERT-tsLT fibroblasts Proliferation Colony-forming cell assay Nki library Genome-wide shRNA np np
GR00098-A-1 23139 ENSG00000086015 MAST2 ENSG00000086015 sp Increased G2M DNA content no Cell division (1) Genome-scale RNAi profiling of cell division in human tissue culture cells. Kittler et al. 2007 17994010 Cell line HeLa Cell number and DNA content Laser scanning cytometry rp Genome-wide esiRNA Complex, sp Complex criteria
GR00114-A 23139 MAST2 np 0.1 none 98% Combinatorial effect with Poly (ADP‐ribose)‐polymerase‐1 (PARP) A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. Turner et al. 2008 18388863 Cell line CAL51 Viability Luminescence siARRAY SMARTpool Kinases siRNA Z-score < Growth rates (%) for vehicle-alone experiments are given in the comment field.
GR00123-A 23139 NM_015112 MAST205 101961, 101962, 101963 np none Combinatorial effect with nutlin-3 An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors Brummelkamp et al. 2006 16474381 Cell line MCF-7 Viability Fluoresence Nki library Genome-wide shRNA log2 ratio np
GR00133-A-1 23139 23139 MAST2 np -0.115323 none no Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Misselwitz et al. 2011 21407211 Cell line HeLa Gentamycin protection invasion assay Fluorescence Druggable genome library V2.0 Druggable genes siRNA log2 median Complex criteria
GR00141-A 23139 NM_015112 MAST2 np np none no T cell chemotaxis Synaptotagmin-mediated vesicle fusion regulates cell migration. Colvin et al. 2010 20473299 Cell line SupT1 Cell migration Fluorescence shRNA Library Kinases, phosphatases and selected genes shRNA Chemotactic index > 1 standard deviation from plate mean by at least 2 shRNAs
GR00143-A 23139 MAST2 MAST2 s1 sp none no tau phosphorylation High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. Azorsa et al. 2010 20067632 Cell line H4 overexpressing 4RON tau Total tau and 12E8 tau protein expression Fluorescence Validated human kinase siRNA Set 2.0 Kinases siRNA p-value Complex criteria
GR00143-A 23139 MAST2 MAST2 s2 sp none no tau phosphorylation High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. Azorsa et al. 2010 20067632 Cell line H4 overexpressing 4RON tau Total tau and 12E8 tau protein expression Fluorescence Validated human kinase siRNA Set 2.0 Kinases siRNA p-value Complex criteria
GR00149-A-1 23139 23139 MAST2 975 4.56 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 23139 23139 MAST2 975 -7.04 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 23139 23139 MAST2 977 -61.08 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 23139 23139 MAST2 977 -52.44 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 23139 23139 MAST2 103437 -15.86 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 23139 23139 MAST2 103437 19.11 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00151-A-1 23139 ENSG00000086015 MAST2 np -0.225 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (1) A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. SÅ‚abicki et al. 2010 20613862 Cell line HeLa (HR-DSBR) DR-GFP reporter Flow cytometry Custom-made Genome-wide esiRNA Z-score < -2 OR > 2
GR00155-A 23139 23139 MAST2 MAST2_1, MAST2_2, MAST2_3 np none no Aryl hydrocarbon receptor (AhR) transduction pathway regulation RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity. Gilot et al. 2011 21479225 Cell line MCF-7 TCDD-induced CYP1A1-related EROD activity and cell viability Fluorescence and methylene blue MISSION siRNA Human Kinase Panel library Kinases siRNA Z-score Top 150 for >
GR00180-A-1 23139 23139 MAST2 PL-50002 0.915 none no Hepatitis C virus replication (1) A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Tai et al. 2009 19286138 Cell line Huh7/Rep-Feo HCV replicon RNA copy number Luminescence siARRAY Human Genome siRNA Library Genome-wide siRNA q-value Complex criteria
GR00184-A-1 23139 NM_015112 MAST2 M-004633-00 -1.3128458706272 none no Self-renewal and pluripotency in human embryonic stem cells (1) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 POU5F1 protein expression Fluorescence SMARTpool siRNA library Genome-wide siRNA Z-score < -2
GR00193-A-1 23139 23139 MAST205 MAST205 0.0169167374243481 Decreased substrate adherent cell growth yes Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (1) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line EBC1 Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00193-A-2 23139 23139 MAST205 MAST205 1.12228469961527 none yes Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (2) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line KELLY Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00193-A-3 23139 23139 MAST205 MAST205 0.909427292536148 none yes Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (3) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line SKNAS Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00193-A-4 23139 23139 MAST205 MAST205 1.15323303457106 none no Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (4) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line NLF Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00196-A-1 23139 ENSG00000086015 np sp none no TP53 interactions (1) A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. Krastev et al. 2011 21642980 Cell line HCT116 ( wildtype and TP53 knockout) TP53 protein expression and viability Fluorescence rp Genome-wide esiRNA Complex, sp Complex criteria
GR00197-A-1 23139 23139 MAST2 M-004633-00 -0.64843427 none no Human papillomavirus oncogene expression regulation (1) Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Smith et al. 2010 20133580 Cell line C33A/BE2/18LCR c4 HPV18 LCR reporter activity Luminescence Human siGENOME SMARTpool library Genome-wide siRNA Z-score > Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5
GR00210-A 23139 23139 MAST2 np sp none no Focal adhesion formation Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown. Winograd-Katz et al. 2009 19667130 Cell line HeLa paxillin protein expression Fluorescence SMARTpool siARRAY siRNA Libraries Kinases, phosphatases and selected genes siRNA Z-score > 3.5 OR < -3.5
GR00221-A-1 23139 MAST2 TRCN0000001733 -0.54 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 23139 MAST2 TRCN0000001735 0.09 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 23139 MAST2 TRCN0000001734 0.3 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 23139 MAST2 TRCN0000001736 1.27 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 23139 MAST2 TRCN0000001734 -0.72 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 23139 MAST2 TRCN0000001733 0.04 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 23139 MAST2 TRCN0000001735 0.08 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 23139 MAST2 TRCN0000001736 0.73 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 23139 MAST2 TRCN0000001734 -1.32 Decreased viability yes essential gene Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 23139 MAST2 TRCN0000001733 -1.04 Decreased viability yes essential gene Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 23139 MAST2 TRCN0000001736 -0.41 none yes essential gene Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 23139 MAST2 TRCN0000001735 -0.17 none yes essential gene Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 23139 MAST2 TRCN0000001733 -3.18 Decreased viability no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 23139 MAST2 TRCN0000001734 -2.11 Decreased viability no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 23139 MAST2 TRCN0000001735 -0.85 none no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 23139 MAST2 TRCN0000001736 0.28 none no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00225-A 23139 MAST2 MAST2_A -0.549711 none 10nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
GR00225-A 23139 MAST2 MAST2_B -1.038618 none 10nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
GR00225-A 23139 MAST2 MAST2_A -0.054323 none 5nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
GR00225-A 23139 MAST2 MAST2_B -0.056319 none 5nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
23139 NM_015112 MAST2 np 1.629869 none no
GR00231-A 23139 NM_015112 MAST2 M-004633-00 -0.792 none yes Cell proliferation Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation. Zhang et al. 2011 21765947 Cell line HeLa Viability Electrical impedance Human siARRAY - Protein Kinase and Cell Cycle libraries Kinases and selected genes siRNA Z-score < -1.96 OR > 1.96 Additional information about cell titer blue cell viability screen
GR00234-A-1 23139 NM_015112 MAST2 np sp none no Hepatitis C virus (HCV) infection (1) EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Lupberger et al. 2011 21516087 Cell line Huh7 Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) protein expression Luminescence Human Kinase RNAi Set V2.0 Kinases siRNA Complex, sp Complex criteria
GR00236-A-1 23139 23139 MAST2 M-004633-00 0.936259519432787 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (1) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Adamson et al. 2012 22344029 Cell line DR-U2OS (HR-DSBR) DR-GFP reporter and DNA content Fluorescence Human siGENOME siRNA (G-005000-05) Genome-wide siRNA Relative HR ratio < ~0.4 OR > 1.88 Cutoff values correspond 2 standard deviations from the screen-wide mean
GR00240-S-1 23139 NM_015112 MAST2 M-004633-00 0.78 none yes TRAIL-induced apoptosis (1) A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. Kranz and Boutros 2014 24442637 Cell line U251MG Viability Luminescence SMART-pool siRNA Genome-wide siRNA Z-score > 4 Author-submitted data
GR00240-S-2 23139 NM_015112 MAST2 M-004633-00 -0.61 none no Z-score 0.1985 TRAIL-induced apoptosis (2) A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. Kranz and Boutros 2014 24442637 Cell line U251MG Viability (synthetic lethal) Luminescence SMART-pool siRNA Genome-wide siRNA Differential score > 3.6 AND viability Z-score < 4 Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen.
GR00242-A-1 23139 NM_015112 MAST2 np sp none no Selective autophagy regulation (1) Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl et al. 2011 22020285 Cell line HeLa/GFP-LC3 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression Fluorescence siGenome Genome-wide siRNA Z-score Complex criteria
GR00247-A-1 23139 MAST2 np sp none rank: 17057 Regulation of FOXO1 nuclear localization (1) Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Senapedis et al. 2011 21460183 Cell line U2OS EGFP-FOXO1a protein expression and DNA content Fluorescence Human Genome library Genome-wide siRNA Complex, sp Complex criteria
GR00248-A 23139 NM_015112 MAST2 MAST2_siRNA1 -0.224 none Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00248-A 23139 NM_015112 MAST2 MAST2_siRNA2 -0.056 none Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00248-A 23139 NM_015112 MAST2 MAST2_siRNA3 -0.143 none Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00249-S 23139 23139 MAST2 J-004633-05 -1.2958 none no number of cells compared to control (%): 85.32 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 23139 23139 MAST2 M-004633-01 1.50177 Decreased viability no number of cells compared to control (%): 45.78 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 23139 23139 MAST2 s42 -0.33057 none no number of cells compared to control (%): 91.37 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 23139 23139 MAST2 s43 1.19086 Increased vaccinia virus (VACV) infection no number of cells compared to control (%): 89.05 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 23139 23139 MAST2 s44 -0.4918 none no number of cells compared to control (%): 79.61 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00253-A 23139 NM_015112 MAST2 np 0.051 none hepcidin regulation Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Mleczko-Sanecka et al. 2014 24385536 Cell line Huh7 hepcidin::fluc mRNA expression Luminescence siGenome siARRAY SMARTpool Genome-wide siRNA Z-score > Cutoff <
GR00255-A-1 23139 23139 MAST2 TRCN0000001733, TRCN0000001734, TRCN0000001735, TRCN0000001736, TRCN0000010650 -0.097715052 none Negative genetic interactions (1) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-2 23139 23139 MAST2 TRCN0000001733, TRCN0000001734, TRCN0000001735, TRCN0000001736, TRCN0000010650 -0.923272829 none Negative genetic interactions (2) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-3 23139 23139 MAST2 TRCN0000001733, TRCN0000001734, TRCN0000001735, TRCN0000001736, TRCN0000010650 -0.731917426 none Negative genetic interactions (3) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-4 23139 23139 MAST2 TRCN0000001733, TRCN0000001734, TRCN0000001735, TRCN0000001736, TRCN0000010650 0.034291039 none Negative genetic interactions (4) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-5 23139 23139 MAST2 TRCN0000001733, TRCN0000001734, TRCN0000001735, TRCN0000001736, TRCN0000010650 0.89679949 none Negative genetic interactions (5) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -0.8 HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00256-A 23139 NM_015112 MAST2 np sp none p-value < 1,0*10^-13 in >1 kind of siRNA Kinase-mediated spindle orientation ABL1 regulates spindle orientation in adherent cells and mammalian skin. Matsumara et al. 2012 22252550 Cell line HeLa beta-tubulin protein expression and DNA content Fluorescence Silencer Kinase siRNA library (AM80010V3) Kinases siRNA Complex, sp Complex criteria HeLa cells stably expressing GFP-H2B (HeLa-GH2B) used. Additional information about secondary screens.
GR00257-A-1 23139 mast2 977 sp Decreased viability (cell death) Cell division, migration and survival (1) Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Neumann et al. 2010 20360735 Cell line HeLa H2B-GFP protein expression Fluorescence Mapped using ENSEMBL genome database version 27 Selected genes siRNA Complex, sp Complex criteria HeLa-H2B-GFP cells used.
GR00293-A 23139 MAST2 np -0.101 none Combinatorial effect with paclitaxel Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death Sinnott et al. 2014 24860162 Cell line HCC366 Viability Luminescence Thermo-Fisher Genome-wide siRNA Z-score < -2.5 Final hits according to the author are indicated in the comment.
GR00300-A 23139 PRKY TRCN0000006343, TRCN0000006344, TRCN0000006345, TRCN0000199818, TRCN0000199518, TRCN0000199828, TRCN0000199331, TRCN0000199051, TRCN0000006346 0 none Combinatorial effect with RAF inhibitor PLX4720 A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Whittaker et al. 2013 23288408 Cell line A375 shRNA abundance Sequencing TRC Genome-wide shRNA Number of shRNAs ranked Top1000 > 2 The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors.
GR00300-A 23139 MAST2 TRCN0000001735, TRCN0000001734, TRCN0000001736, TRCN0000010650, TRCN0000001733 0 none Combinatorial effect with RAF inhibitor PLX4720 A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Whittaker et al. 2013 23288408 Cell line A375 shRNA abundance Sequencing TRC Genome-wide shRNA Number of shRNAs ranked Top1000 > 2 The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors.
GR00303-A 23139 NM_015112 MAST2 np -2.43 none Clear cell renal cell carcinoma (ccRCC) survival regulation Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target Gerlinger et al. 2012 22362593 Cell line VHL-deficient RCC4 Proliferation and Viability Fluorescence np Genome-wide siRNA Z-score < In the phenotype data duplicates were in the original document, which have been removed.
GR00310-A-1 23139 23139 MAST2 np -2.26 none Sindbis virus (SINV) infection (1) Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry Ooi et al. 2013 24367265 Cell line U2OS Sindbis virus (SINV) reporter Luminescence Ambion Silencer V3 Genome-wide siRNA Z-score < -3 OR > 2
23139 23139 MAST2 np 45.3 none 83,9% viability
GR00313-A 23139 NM_015112 MAST2 np 1.47 none TNF-alpha pathway regulation A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. Nickles et al. 2012 22733992 Cell line HEK293T NFkappaB pathway reporter Luminescence Qiagen Genome-wide siRNA Z-score < Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%.
GR00318-A 23139 23139 MAST2 np 1.359 none siRNA set: kinase Huntingtin toxicity A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease Miller et al. 2012 23209424 Cell line HEK293T Caspase 3/7 activity Fluorescence Dharmacon Selected genes siRNA Sum of normalized caspase 3/7 activity mean and standard error < 0.683 HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP).
GR00342-S-1 23139 MAST2 M-004633-00 -0.359482023547539 none Viability of Mesenchymal Stem Cells (MSC) (1) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 1, MSC preparation 1 (MSC1a)
GR00342-S-2 23139 MAST2 M-004633-00 0.5639258612002391 none Viability of Mesenchymal Stem Cells (MSC) (2) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 1, MSC preparation 2 (MSC1b)
GR00342-S-3 23139 MAST2 M-004633-00 0.20077822017519797 none Viability of Mesenchymal Stem Cells (MSC) (3) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 2, MSC preparation 1 (MSC2)
GR00343-S 23139 23139 MAST2 TRCN0000001736 0.7050000000000001 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 23139 23139 MAST2 TRCN0000001734 -1.5575 shRNA abundance <= 50% Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 23139 23139 MAST2 TRCN0000001735 0.7475000000000005 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 23139 23139 MAST2 TRCN0000001733 -0.15750000000000064 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00355-A 23139 23139 MAST2 np np none PIP3-mediated epidermal growth factor (EGFR) endocytosis PIP3 induces the recycling of receptor tyrosine kinases Laketa et al. 2014 24425787 Cell line HeLa Kyoto Epidermal growth factor (EGFR) surface abundance Fluorescence Qiagen Selected genes siRNA Deviation score < -1 OR > 1 HeLa Kyoto cells were stably transfected with EGFR-EYFP. Reagent Sequences (but no reagent ID) available in Table S4.
GR00356-A-1 23139 NM_015112 MAST205 np 0.3 Decreased vesicular stomatitis virus (VSV) infection Clathrin-mediated endocytosis Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Pelkmans et al. 2005 15889048 Cell line HeLa Vesicular stomatitis virus (VSV) infection (rVSV–GFP expression) Fluorescence Ambion Kinases siRNA Relative infection index (RII) < The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Caveolin- and lipid raft-mediated endocytosis" using simian virus 40 (SV40).
GR00356-A-2 23139 NM_015112 MAST205 np 0.6965430893536084 none Caveolin- and lipid raft-mediated endocytosis Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Pelkmans et al. 2005 15889048 Cell line HeLa Simian virus 40 (SV40) infection (SV40 large T-antigen expression) Fluorescence Ambion Kinases siRNA Relative infection index (RII) < The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Clathrin-mediated endocytosis" using vesicular stomatitis virus (VSV).
GR00356-A-3 23139 NM_015112 MAST205 np np toxic Endocytosis regulation Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Pelkmans et al. 2005 15889048 Cell line HeLa Transferrin (Tfn) uptake and trafficking Fluorescence Ambion Kinases siRNA np np
GR00360-A-1 23139 ENSG00000086015 MAST2 975 1.9698 Strongly decreased CFP-tsO45G cell surface transport Secretory transport (1) Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway Simpson et al. 2012 22660414 Cell line HeLa Kyoto CFP-tsO45G cell surface transport Fluorescence Ambion Genome-wide siRNA Deviation score < - 1 OR > 0.75 (mild: 0.75 - 1.0; strong: > 1.0) For validation screen see Secretory transport (2).
GR00360-A-1 23139 ENSG00000086015 MAST2 977 np No cells Secretory transport (1) Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway Simpson et al. 2012 22660414 Cell line HeLa Kyoto CFP-tsO45G cell surface transport Fluorescence Ambion Genome-wide siRNA Deviation score < - 1 OR > 0.75 (mild: 0.75 - 1.0; strong: > 1.0) For validation screen see Secretory transport (2).
GR00362-A 23139 23139 MAST2 np np Synthetic lethal with vaccinia virus (VACV) infection Vaccinia virus (VACV) replication A loss of function analysis of host factors influencing Vaccina virus replication by RNA interference Beard et al. 2014 2401222 Cell line HeLa VACV-A5eGFP expression Fluorescence SMARTpools, Dharmacon Genome-wide siRNA Z-score < Genes were prescreened for viability, those declared as lethal were not screened for fluorescence.
GR00366-A-1 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.875521606749729 none MAST2_1_111 Context-specific genetic dependencies (1) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 22RV1_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-10 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.0621725538712365 none MAST2_1_111 Context-specific genetic dependencies (10) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ACHN_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-100 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.0433531485810236 none MAST2_1_111 Context-specific genetic dependencies (100) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-101 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.20293689467279 none MAST2_1_111 Context-specific genetic dependencies (101) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LK2_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-102 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.0397432429955189 none MAST2_1_111 Context-specific genetic dependencies (102) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN215_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-103 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.370645700515954 none MAST2_1_111 Context-specific genetic dependencies (103) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN229_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-104 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.706909909864744 none MAST2_1_111 Context-specific genetic dependencies (104) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN235_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-105 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -2.35618546444563 Decreased shRNA abundance (Z-score < -2) MAST2_1_111 Context-specific genetic dependencies (105) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN319_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-106 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.0206145365351 none MAST2_1_111 Context-specific genetic dependencies (106) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN340_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-107 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.53416856478465 none MAST2_1_111 Context-specific genetic dependencies (107) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN382_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-108 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.02143408952698 none MAST2_1_111 Context-specific genetic dependencies (108) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN428_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-109 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.662055730939319 none MAST2_1_111 Context-specific genetic dependencies (109) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN443_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-11 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.471923013258557 none MAST2_1_111 Context-specific genetic dependencies (11) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AGS_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-110 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.441094953603743 none MAST2_1_111 Context-specific genetic dependencies (110) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN464_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-111 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.187628729719398 none MAST2_1_111 Context-specific genetic dependencies (111) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LNZ308_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-112 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.444158171068626 none MAST2_1_111 Context-specific genetic dependencies (112) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LOVO_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-113 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.179529979727118 none MAST2_1_111 Context-specific genetic dependencies (113) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LS411N_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-114 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.429358722167375 none MAST2_1_111 Context-specific genetic dependencies (114) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LS513_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-115 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.881215024117308 none MAST2_1_111 Context-specific genetic dependencies (115) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MCF7_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-116 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.980802886986735 none MAST2_1_111 Context-specific genetic dependencies (116) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MDAMB453_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-117 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.243968915512821 none MAST2_1_111 Context-specific genetic dependencies (117) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MIAPACA2_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-118 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.104270684718315 none MAST2_1_111 Context-specific genetic dependencies (118) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MKN7_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-119 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.566723452899431 none MAST2_1_111 Context-specific genetic dependencies (119) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-12 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.126790682116061 none MAST2_1_111 Context-specific genetic dependencies (12) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AM38_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-120 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.82894172411175 none MAST2_1_111 Context-specific genetic dependencies (120) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-121 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.66219518025358 Decreased shRNA abundance (Z-score < -2) MAST2_1_111 Context-specific genetic dependencies (121) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-122 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.50414558336047 none MAST2_1_111 Context-specific genetic dependencies (122) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-123 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.636683403961808 none MAST2_1_111 Context-specific genetic dependencies (123) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-124 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.479424880634028 none MAST2_1_111 Context-specific genetic dependencies (124) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-125 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.307064446691904 none MAST2_1_111 Context-specific genetic dependencies (125) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-126 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.155687887240899 none MAST2_1_111 Context-specific genetic dependencies (126) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1299_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-127 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.678556861131196 none MAST2_1_111 Context-specific genetic dependencies (127) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1437_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-128 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.07299372574059 none MAST2_1_111 Context-specific genetic dependencies (128) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1650_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-129 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.11673117970092 none MAST2_1_111 Context-specific genetic dependencies (129) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1792_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-13 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.997539951260792 none MAST2_1_111 Context-specific genetic dependencies (13) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-130 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.0172619428353972 none MAST2_1_111 Context-specific genetic dependencies (130) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH196_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-131 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.43005943073359 none MAST2_1_111 Context-specific genetic dependencies (131) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1975_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-132 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.25330160894594 none MAST2_1_111 Context-specific genetic dependencies (132) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2052_PLEURA shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-133 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.498296946223841 none MAST2_1_111 Context-specific genetic dependencies (133) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2122_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-134 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.313064909413602 none MAST2_1_111 Context-specific genetic dependencies (134) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2171_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-135 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.706221703212342 none MAST2_1_111 Context-specific genetic dependencies (135) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH23_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-136 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.240351710536361 none MAST2_1_111 Context-specific genetic dependencies (136) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2452_PLEURA shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-137 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.48660965639419 none MAST2_1_111 Context-specific genetic dependencies (137) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH441_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-138 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.20163302678528 none MAST2_1_111 Context-specific genetic dependencies (138) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH508_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-139 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.296644663811535 none MAST2_1_111 Context-specific genetic dependencies (139) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH660_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-14 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.42486603207294 none MAST2_1_111 Context-specific genetic dependencies (14) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ASPC1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-140 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.230620114226171 none MAST2_1_111 Context-specific genetic dependencies (140) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH661_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-141 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.155453192685712 none MAST2_1_111 Context-specific genetic dependencies (141) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH716_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-142 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.190296833988559 none MAST2_1_111 Context-specific genetic dependencies (142) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH838_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-143 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.397484281423061 none MAST2_1_111 Context-specific genetic dependencies (143) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIN87_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-144 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.560477238445862 none MAST2_1_111 Context-specific genetic dependencies (144) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NIHOVCAR3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-145 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.451357659323743 none MAST2_1_111 Context-specific genetic dependencies (145) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-146 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.222253212220033 none MAST2_1_111 Context-specific genetic dependencies (146) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OAW42_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-147 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.170066730652032 none MAST2_1_111 Context-specific genetic dependencies (147) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-148 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.584989098470018 none MAST2_1_111 Context-specific genetic dependencies (148) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-149 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.294082806567701 none MAST2_1_111 Context-specific genetic dependencies (149) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-15 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.310859458907733 none MAST2_1_111 Context-specific genetic dependencies (15) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BT20_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-150 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.364830406323569 none MAST2_1_111 Context-specific genetic dependencies (150) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OE33_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-151 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.651849708283685 none MAST2_1_111 Context-specific genetic dependencies (151) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OELE_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-152 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.505576146874801 none MAST2_1_111 Context-specific genetic dependencies (152) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-153 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.591450973848128 none MAST2_1_111 Context-specific genetic dependencies (153) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OV7_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-154 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.476800601239808 none MAST2_1_111 Context-specific genetic dependencies (154) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OV90_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-155 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.767089927853303 none MAST2_1_111 Context-specific genetic dependencies (155) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVCAR4_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-156 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.00735170995438713 none MAST2_1_111 Context-specific genetic dependencies (156) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVCAR8_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-157 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.346695604181572 none MAST2_1_111 Context-specific genetic dependencies (157) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVISE_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-158 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.491595035246518 none MAST2_1_111 Context-specific genetic dependencies (158) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC0327_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-159 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.770122716246669 none MAST2_1_111 Context-specific genetic dependencies (159) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC0813_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-16 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.14439952090343 none MAST2_1_111 Context-specific genetic dependencies (16) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BT474_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-160 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.466544158791389 none MAST2_1_111 Context-specific genetic dependencies (160) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC1005_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-161 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.338657401879646 none MAST2_1_111 Context-specific genetic dependencies (161) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-162 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.163947344619267 none MAST2_1_111 Context-specific genetic dependencies (162) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PSN1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-163 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.41223709221327 none MAST2_1_111 Context-specific genetic dependencies (163) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line QGP1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-164 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.519704694803008 none MAST2_1_111 Context-specific genetic dependencies (164) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-165 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.0432240472521667 none MAST2_1_111 Context-specific genetic dependencies (165) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RKN_SOFT_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-166 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.0164263762889224 none MAST2_1_111 Context-specific genetic dependencies (166) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RKO_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-167 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.200398038000949 none MAST2_1_111 Context-specific genetic dependencies (167) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RMGI_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-168 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.0449557123006888 none MAST2_1_111 Context-specific genetic dependencies (168) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RMUGS_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-169 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.409946854255 none MAST2_1_111 Context-specific genetic dependencies (169) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-17 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.922348596832514 none MAST2_1_111 Context-specific genetic dependencies (17) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BXPC3_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-170 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.269711626209514 none MAST2_1_111 Context-specific genetic dependencies (170) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RT112_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-171 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.13146606303125 none MAST2_1_111 Context-specific genetic dependencies (171) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-172 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.902263555447074 none MAST2_1_111 Context-specific genetic dependencies (172) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF126_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-173 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.04831851590015 none MAST2_1_111 Context-specific genetic dependencies (173) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF172_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-174 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.800710696039412 none MAST2_1_111 Context-specific genetic dependencies (174) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF295_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-175 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.23177085987211 none MAST2_1_111 Context-specific genetic dependencies (175) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF767_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-176 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.958255436228691 none MAST2_1_111 Context-specific genetic dependencies (176) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SJSA1_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-177 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.0678382735182135 none MAST2_1_111 Context-specific genetic dependencies (177) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKCO1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-178 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.646299343287624 none MAST2_1_111 Context-specific genetic dependencies (178) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKMEL5_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-179 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.165370963116574 none MAST2_1_111 Context-specific genetic dependencies (179) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-18 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.0940677912755374 none MAST2_1_111 Context-specific genetic dependencies (18) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line C2BBE1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-180 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.44437644064928 none MAST2_1_111 Context-specific genetic dependencies (180) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-181 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.173109256920122 none MAST2_1_111 Context-specific genetic dependencies (181) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKOV3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-182 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.232094474293764 none MAST2_1_111 Context-specific genetic dependencies (182) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKRC20_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-183 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.671661602650709 none MAST2_1_111 Context-specific genetic dependencies (183) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR20_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-184 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.851330398042992 none MAST2_1_111 Context-specific genetic dependencies (184) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR21_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-185 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.427081655877143 none MAST2_1_111 Context-specific genetic dependencies (185) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR23_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-186 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.249556488392632 none MAST2_1_111 Context-specific genetic dependencies (186) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR24_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-187 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.197098597034661 none MAST2_1_111 Context-specific genetic dependencies (187) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR25_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-188 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.0530192635348577 none MAST2_1_111 Context-specific genetic dependencies (188) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR26_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-189 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.790904457256562 none MAST2_1_111 Context-specific genetic dependencies (189) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNU1105_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-19 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.54907984059902 none MAST2_1_111 Context-specific genetic dependencies (19) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line C32_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-190 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.792969391343666 none MAST2_1_111 Context-specific genetic dependencies (190) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNU840_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-191 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.70944476723718 Decreased shRNA abundance (Z-score < -2) MAST2_1_111 Context-specific genetic dependencies (191) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNUC1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-192 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.420923495598874 none MAST2_1_111 Context-specific genetic dependencies (192) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNUC2A_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-193 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.447305413962403 none MAST2_1_111 Context-specific genetic dependencies (193) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SU8686_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-194 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.66686145369324 none MAST2_1_111 Context-specific genetic dependencies (194) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW1417_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-195 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.52069403540869 none MAST2_1_111 Context-specific genetic dependencies (195) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW1783_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-196 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.72998046483521 Increased shRNA abundance (Z-score > 2) MAST2_1_111 Context-specific genetic dependencies (196) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW480_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-197 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.593777933734491 none MAST2_1_111 Context-specific genetic dependencies (197) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW48_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-198 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.997091061581995 none MAST2_1_111 Context-specific genetic dependencies (198) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line T98G_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-199 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.501526815217135 none MAST2_1_111 Context-specific genetic dependencies (199) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TC71_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-2 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.261855350349786 none MAST2_1_111 Context-specific genetic dependencies (2) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-20 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.136891198607997 none MAST2_1_111 Context-specific genetic dependencies (20) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CADOES1_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-200 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.016835101619563 none MAST2_1_111 Context-specific genetic dependencies (200) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TCCSUP_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-201 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.403466501258912 none MAST2_1_111 Context-specific genetic dependencies (201) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE10_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-202 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.604643081821349 none MAST2_1_111 Context-specific genetic dependencies (202) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE15_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-203 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.855919100446009 none MAST2_1_111 Context-specific genetic dependencies (203) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE9_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-204 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.842554712959262 none MAST2_1_111 Context-specific genetic dependencies (204) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-205 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.063566402296109 none MAST2_1_111 Context-specific genetic dependencies (205) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TOV112D_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-206 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.11168650943312 none MAST2_1_111 Context-specific genetic dependencies (206) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TOV21G_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-207 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.087779978060794 none MAST2_1_111 Context-specific genetic dependencies (207) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TT_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-208 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.696089227012038 none MAST2_1_111 Context-specific genetic dependencies (208) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TYKNU_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-209 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.0805558085586 none MAST2_1_111 Context-specific genetic dependencies (209) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U178_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-21 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.38542636833794 none MAST2_1_111 Context-specific genetic dependencies (21) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAL120_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-210 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.983341327515727 none MAST2_1_111 Context-specific genetic dependencies (210) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U251MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-211 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.88756928108875 Increased shRNA abundance (Z-score > 2) MAST2_1_111 Context-specific genetic dependencies (211) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U343_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-212 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.470939284810738 none MAST2_1_111 Context-specific genetic dependencies (212) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U87MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-213 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.917707647235959 none MAST2_1_111 Context-specific genetic dependencies (213) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line UOK101_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-214 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.48151130171448 none MAST2_1_111 Context-specific genetic dependencies (214) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line VCAP_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-215 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.432648179836189 none MAST2_1_111 Context-specific genetic dependencies (215) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line YKG1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-216 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.73559565157215 Decreased shRNA abundance (Z-score < -2) MAST2_1_111 Context-specific genetic dependencies (216) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ZR7530_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-22 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.597584649691626 none MAST2_1_111 Context-specific genetic dependencies (22) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAL51_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-23 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.642897877646464 none MAST2_1_111 Context-specific genetic dependencies (23) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CALU1_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-24 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.453054303651396 none MAST2_1_111 Context-specific genetic dependencies (24) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAOV3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-25 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.298047462018067 none MAST2_1_111 Context-specific genetic dependencies (25) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAOV4_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-26 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.538699542768785 none MAST2_1_111 Context-specific genetic dependencies (26) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAS1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-27 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.00159484808393 none MAST2_1_111 Context-specific genetic dependencies (27) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CFPAC1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-28 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.0701105241943411 none MAST2_1_111 Context-specific genetic dependencies (28) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CH157MN_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-29 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.962169171479775 none MAST2_1_111 Context-specific genetic dependencies (29) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO205_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-3 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.271636899112027 none MAST2_1_111 Context-specific genetic dependencies (3) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 786O_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-30 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.336808137356885 none MAST2_1_111 Context-specific genetic dependencies (30) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO704_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-31 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.33563811401478 none MAST2_1_111 Context-specific genetic dependencies (31) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO741_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-32 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.976537834049145 none MAST2_1_111 Context-specific genetic dependencies (32) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO783_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-33 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.0219848744825579 none MAST2_1_111 Context-specific genetic dependencies (33) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CORL23_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-34 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.17335549297467 none MAST2_1_111 Context-specific genetic dependencies (34) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV362_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-35 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.29208217173652 none MAST2_1_111 Context-specific genetic dependencies (35) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV434_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-36 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 2.37869923917737 Increased shRNA abundance (Z-score > 2) MAST2_1_111 Context-specific genetic dependencies (36) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV504_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-37 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.14162568157402 none MAST2_1_111 Context-specific genetic dependencies (37) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV644_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-38 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.806872840845249 none MAST2_1_111 Context-specific genetic dependencies (38) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DBTRG05MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-39 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.86371099403965 Increased shRNA abundance (Z-score > 2) MAST2_1_111 Context-specific genetic dependencies (39) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DKMG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-4 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.51124696492831 none MAST2_1_111 Context-specific genetic dependencies (4) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A1207_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-40 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.0904047557612175 none MAST2_1_111 Context-specific genetic dependencies (40) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DLD1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-41 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.8713820366919 none MAST2_1_111 Context-specific genetic dependencies (41) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFE184_ENDOMETRIUM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-42 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.191534873071936 none MAST2_1_111 Context-specific genetic dependencies (42) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFM19_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-43 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.0968819815552512 none MAST2_1_111 Context-specific genetic dependencies (43) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFO21_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-44 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.223993733115404 none MAST2_1_111 Context-specific genetic dependencies (44) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFO27_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-45 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.150146768096895 none MAST2_1_111 Context-specific genetic dependencies (45) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EW8_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-46 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.190089026423281 none MAST2_1_111 Context-specific genetic dependencies (46) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EWS502_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-47 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.621687086629453 none MAST2_1_111 Context-specific genetic dependencies (47) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-48 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.727949823701218 none MAST2_1_111 Context-specific genetic dependencies (48) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line GB1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-49 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.0782149545137823 none MAST2_1_111 Context-specific genetic dependencies (49) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line GP2D_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-5 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.45751082692988 none MAST2_1_111 Context-specific genetic dependencies (5) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A172_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-50 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.04979471047053 none MAST2_1_111 Context-specific genetic dependencies (50) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1187_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-51 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.03412594596749 none MAST2_1_111 Context-specific genetic dependencies (51) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1395_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-52 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.367954150163929 none MAST2_1_111 Context-specific genetic dependencies (52) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1954_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-53 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.75318280976061 Decreased shRNA abundance (Z-score < -2) MAST2_1_111 Context-specific genetic dependencies (53) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC2218_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-54 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.0654755007620383 none MAST2_1_111 Context-specific genetic dependencies (54) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC2814_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-55 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.523918701860177 none MAST2_1_111 Context-specific genetic dependencies (55) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC364_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-56 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.19908122712327 none MAST2_1_111 Context-specific genetic dependencies (56) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC44_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-57 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.144911185719204 none MAST2_1_111 Context-specific genetic dependencies (57) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC70_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-58 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.21828308673225 none MAST2_1_111 Context-specific genetic dependencies (58) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC827GR5_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-59 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.3631511160052 none MAST2_1_111 Context-specific genetic dependencies (59) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC827_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-6 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.406630843909097 none MAST2_1_111 Context-specific genetic dependencies (6) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A204_SOFT_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-60 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.777646917956756 none MAST2_1_111 Context-specific genetic dependencies (60) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCT116_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-61 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.670785596237531 none MAST2_1_111 Context-specific genetic dependencies (61) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HEC1A_ENDOMETRIUM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-62 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.716821788883006 none MAST2_1_111 Context-specific genetic dependencies (62) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HEYA8_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-63 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.131385342219211 none MAST2_1_111 Context-specific genetic dependencies (63) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-64 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.0526996570795047 none MAST2_1_111 Context-specific genetic dependencies (64) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HLF_LIVER shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-65 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.718663874549582 none MAST2_1_111 Context-specific genetic dependencies (65) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-66 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.303944288013665 none MAST2_1_111 Context-specific genetic dependencies (66) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HPAC_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-67 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.755677416592173 none MAST2_1_111 Context-specific genetic dependencies (67) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HPAFII_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-68 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.505717997332905 none MAST2_1_111 Context-specific genetic dependencies (68) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS683_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-69 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.466468927853629 none MAST2_1_111 Context-specific genetic dependencies (69) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS766T_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-7 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.192240660469433 none MAST2_1_111 Context-specific genetic dependencies (7) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A2058_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-70 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.197124654811723 none MAST2_1_111 Context-specific genetic dependencies (70) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS944T_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-71 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.714144977757191 none MAST2_1_111 Context-specific genetic dependencies (71) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT1197_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-72 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.06381283719881 none MAST2_1_111 Context-specific genetic dependencies (72) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT29_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-73 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.439948770227503 none MAST2_1_111 Context-specific genetic dependencies (73) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT55_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-74 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.617900276393117 none MAST2_1_111 Context-specific genetic dependencies (74) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HUG1N_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-75 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.60097306849587 Increased shRNA abundance (Z-score > 2) MAST2_1_111 Context-specific genetic dependencies (75) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HUTU80_SMALL_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-76 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.625770967362717 none MAST2_1_111 Context-specific genetic dependencies (76) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IGR39_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-77 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.462034007101344 none MAST2_1_111 Context-specific genetic dependencies (77) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IGROV1_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-78 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.609507683241569 none MAST2_1_111 Context-specific genetic dependencies (78) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IOMMLEE_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-79 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.80550281663284 none MAST2_1_111 Context-specific genetic dependencies (79) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHESOAD1_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-8 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.806203376113146 none MAST2_1_111 Context-specific genetic dependencies (8) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A549_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-80 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.154058918562913 none MAST2_1_111 Context-specific genetic dependencies (80) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHOC5_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-81 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.670728401572581 none MAST2_1_111 Context-specific genetic dependencies (81) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHOM1_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-82 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.631923374898357 none MAST2_1_111 Context-specific genetic dependencies (82) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-83 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.1131251280939 none MAST2_1_111 Context-specific genetic dependencies (83) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-84 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.182282483015098 none MAST2_1_111 Context-specific genetic dependencies (84) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KALS1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-85 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.21312665409446 none MAST2_1_111 Context-specific genetic dependencies (85) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-86 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.432368086200248 none MAST2_1_111 Context-specific genetic dependencies (86) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KM12_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-87 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -1.20008560611566 none MAST2_1_111 Context-specific genetic dependencies (87) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-88 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.0463685218428485 none MAST2_1_111 Context-specific genetic dependencies (88) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KNS60_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-89 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.568879075970829 none MAST2_1_111 Context-specific genetic dependencies (89) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KNS81_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-9 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.0540258804223 none MAST2_1_111 Context-specific genetic dependencies (9) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A673_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-90 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.221391044988472 none MAST2_1_111 Context-specific genetic dependencies (90) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP1NL_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-91 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.740354792626017 none MAST2_1_111 Context-specific genetic dependencies (91) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP2_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-92 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.210842913745747 none MAST2_1_111 Context-specific genetic dependencies (92) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP4_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-93 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.335667566900589 none MAST2_1_111 Context-specific genetic dependencies (93) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KURAMOCHI_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-94 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 0.193351144760601 none MAST2_1_111 Context-specific genetic dependencies (94) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE150_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-95 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.0608120127112925 none MAST2_1_111 Context-specific genetic dependencies (95) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE30_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-96 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.0662161444804312 none MAST2_1_111 Context-specific genetic dependencies (96) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE450_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-97 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.412293449794964 none MAST2_1_111 Context-specific genetic dependencies (97) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE510_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-98 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 1.97584771744195 Increased shRNA abundance (Z-score > 2) MAST2_1_111 Context-specific genetic dependencies (98) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line L33_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-99 23139 MAST2 TRCN0000001735, TRCN0000344617, TRCN0000344618 -0.138977559534326 none MAST2_1_111 Context-specific genetic dependencies (99) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00368-A 23139 23139 MAST2 0.58 Decreased viability ratio wt viability: 0,66 Combinatorial effect with E-Cadherin Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin–Deficient Cells Telford et al. 2015 25777964 Cell line MCF10A Viability (synthetic lethal) Luminescence Dharmacon Genome-wide siRNA CDH1(-/-)/wt viability ratio < MCF10A wild type viability higher-or-equal to 50% was considered as additional cutoff (values noted in "comment" section).
23139 23139 MAST2 -0.05000000000000002 none
GR00371-A-1 23139 23139 MAST2 0.391883128689 none Dharmacon Nanog expression in absence of bFGF and TGFbeta Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-2 23139 MAST2 23139 0.159903512907 none Dharmacon Nanog expression in presence of TGFbeta inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-3 23139 23139 MAST2 0.00496633273077 none Dharmacon Nanog expression in presence of MEK inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-4 23139 23139 MAST2 0.209017267745 none Dharmacon Nanog expression in presence of PI3K inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-5 23139 23139 MAST2 -0.742027265426 none Dharmacon Nanog expression in presence of retinoic acid Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00376-A-1 23139 23139 MAST2 0.128377251 none Mitigators of SS1P-induced immunotoxicity Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity Pasetto et al. 2015 25713356 Cell line KB cells Viability Luminescence Ambion Silencer Select Version 4 Genome-wide siRNA RSA P-value <0.001 SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID
GR00376-A-2 23139 23139 MAST2 0.282986011 none Sensitizers of SS1P-induced immunotoxicity Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity Pasetto et al. 2015 25713356 Cell line KB cells Viability Luminescence Ambion Silencer Select Version 4 Genome-wide siRNA RSA P-value <0.001 SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID
GR00378-A 23139 MAST2 -0.230032227 none Poliovirus vaccine production Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game van der Sanden et al. 2015 26581994 Cell line HEp-2C Infection with Attenuated Poliovirus ELISA Dharmacon Genome-wide siRNA Z-score > For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol
23139 NM_015112 MAST2 59.826 none
GR00386-A-1 23139 23139 MAST2 83.9718387546539 none NOD2 stimulation by MDP A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. Warner et al. 2014 25170077 Cell line HEK293 stably expressing NOD2 Viability Luminescence Dharmacon Genome-wide siRNA Percentage growth Decreased: <70, increased: >120 Reagent IDs not provided
GR00386-A-2 23139 23139 MAST2 -106.9 none MDP-induced IL-8 secretion A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. Warner et al. 2014 25170077 Cell line HEK293 stably expressing NOD2 IL-8 secretion ELISA Dharmacon Genome-wide siRNA Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided