RNAi

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 23141
• Symbol: ANKLE2
• Description: ankyrin repeat and LEM domain containing 2

DataSource: http://genomernai.dkfz.de/v16/genedetails/23141

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Stable_ID	Entrez_ID	Gene_ID	Gene_Symbol	Reagent_ID	Score	Phenotype	Conditions	Follow_Up	Comment	Screen_Title	Publication_Title	Authors	Publication_Year	Pubmed_ID	Biosource	Biomodel	Assay	Method	Library	Scope	Reagent_Type	Score_Type	Cutoff	Notes
GR00098-A-1	23141	ENSG00000176915	KIAA0692	ENSG00000176915	sp	none		no		Cell division (1)	Genome-scale RNAi profiling of cell division in human tissue culture cells.	Kittler et al.	2007	17994010	Cell line	HeLa	Cell number and DNA content	Laser scanning cytometry	rp	Genome-wide	esiRNA	Complex, sp	Complex criteria
GR00151-A-1	23141	ENSG00000176915	ANKLE2	np	-0.136	none		no		Homologous recombination DNA double-strand break repair (HR-DSBR) (1)	A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.	SÅ‚abicki et al.	2010	20613862	Cell line	HeLa	(HR-DSBR) DR-GFP reporter	Flow cytometry	Custom-made	Genome-wide	esiRNA	Z-score	< -2 OR > 2
GR00196-A-1	23141	ENSG00000176915		np	sp	none		no		TP53 interactions (1)	A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly.	Krastev et al.	2011	21642980	Cell line	HCT116 ( wildtype and TP53 knockout)	TP53 protein expression and viability	Fluorescence	rp	Genome-wide	esiRNA	Complex, sp	Complex criteria
GR00249-S	23141	23141	KIAA0692	s23124	1.44809	Increased vaccinia virus (VACV) infection		no	number of cells compared to control (%): 91.26	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	23141	23141	KIAA0692	s23125	-1.253	none		no	number of cells compared to control (%): 79.80	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	23141	23141	KIAA0692	s23126	0.38618	none		no	number of cells compared to control (%): 103.97	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00376-A-1	23141	23141	KIAA0692		0.16776318	none				Mitigators of SS1P-induced immunotoxicity	Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity	Pasetto et al.	2015	25713356	Cell line	KB cells	Viability	Luminescence	Ambion Silencer Select Version 4	Genome-wide	siRNA	RSA P-value	<0.001	SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID
GR00376-A-2	23141	23141	KIAA0692		0.353416413	none				Sensitizers of SS1P-induced immunotoxicity	Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity	Pasetto et al.	2015	25713356	Cell line	KB cells	Viability	Luminescence	Ambion Silencer Select Version 4	Genome-wide	siRNA	RSA P-value	<0.001	SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID