RNAi

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 2710
• Symbol: GK
• Description: glycerol kinase

DataSource: http://genomernai.dkfz.de/v16/genedetails/2710

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Stable_ID	Entrez_ID	Gene_ID	Gene_Symbol	Reagent_ID	Score	Phenotype	Conditions	Follow_Up	Comment	Screen_Title	Publication_Title	Authors	Publication_Year	Pubmed_ID	Biosource	Biomodel	Assay	Method	Library	Scope	Reagent_Type	Score_Type	Cutoff	Notes
GR00053-A	2710	NM_000167	GK	np	sp	none		no		Genome stability	A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.	Paulsen et al.	2009	19647519	Cell line	HeLa	gamma-H2AX phosphorylation and DNA content	Fluorescence	siARRAY human genome siRNA library	Genome-wide	siRNA	p-value	Complex criteria	Confidence groupings from 4 to 1 (highest level of confidence in group 4)
GR00054-A	2710	NM_000167	GK	np	0.97	none		no		Combinatorial effect with paclitaxel	Synthetic lethal screen identification of chemosensitizer loci in cancer cells.	Whitehurst et al.	2007	17429401	Cell line	NCI-H1155	Viability (synthetic lethal)	ATP level	# G-005000-01	Genome-wide	siRNA	Paclitaxel/control ratio	Complex criteria	Additional information about 87 high-confidence hits
GR00056-A	2710	NM_000167	GK	np	1.647	none		no		Melanogenesis	Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.	Ganesan et al.	2008	19057677	Cell line	MNT-1	Melanin protein expression and viability	Absorbance and luminescence	rp	Genome-wide	siRNA	Normalized absorbance ratio	> 2 standard deviations below mean	Additional information about a secondary screen (retest to determine false-positive rate)
GR00057-A-1	2710	NM_000167	GK	M-006727-00	-1.33	none		no		Wnt/beta-catenin pathway regulation (1)	A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer.	Tang et al.	2008	18621708	Cell line	HeLa	Wnt pathway reporter	Luminescence	Human siArray siRNA library	Genome-wide	siRNA	Z-score	> 4	Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00057-A-2	2710	NM_000167	GK	M-006727-00	sp	none		no		Wnt/beta-catenin pathway regulation (2)	A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer.	Tang et al.	2008	18621708	Cell line	HeLa	Wnt pathway reporter	Luminescence	Human siArray siRNA library	Genome-wide	siRNA	Complex, SP	Complex criteria	Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00095-A	2710	NM_000167	GK	np	np	none				p53 pathway components	A large-scale RNAi screen in human cells identifies new components of the p53 pathway	Berns et al.	2004	15042092	Cell line	BJ-TERT-tsLT fibroblasts	Proliferation	Colony-forming cell assay	Nki library	Genome-wide	shRNA	np	np
GR00098-A-1	2710	ENSG00000170095	GK	ENSG00000170095	sp	none		no		Cell division (1)	Genome-scale RNAi profiling of cell division in human tissue culture cells.	Kittler et al.	2007	17994010	Cell line	HeLa	Cell number and DNA content	Laser scanning cytometry	rp	Genome-wide	esiRNA	Complex, sp	Complex criteria
GR00114-A	2710		GK	np	1.16	none			115%	Combinatorial effect with Poly (ADP‐ribose)‐polymerase‐1 (PARP)	A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.	Turner et al.	2008	18388863	Cell line	CAL51	Viability	Luminescence	siARRAY SMARTpool	Kinases	siRNA	Z-score	<	Growth rates (%) for vehicle-alone experiments are given in the comment field.
GR00123-A	2710	NM_000167	GK	143751, 143752, 143753	np	none				Combinatorial effect with nutlin-3	An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors	Brummelkamp et al.	2006	16474381	Cell line	MCF-7	Viability	Fluoresence	Nki library	Genome-wide	shRNA	log2 ratio	np
GR00133-A-1	2710	2710	GK	np	0.29409	none		no		Salmonella enterica subspecies 1 serovar Typhimurium invasion (1)	RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42.	Misselwitz et al.	2011	21407211	Cell line	HeLa	Gentamycin protection invasion assay	Fluorescence	Druggable genome library V2.0	Druggable genes	siRNA	log2 median	Complex criteria
GR00143-A	2710		GK	GK s1	sp	none		no		tau phosphorylation	High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.	Azorsa et al.	2010	20067632	Cell line	H4 overexpressing 4RON tau	Total tau and 12E8 tau protein expression	Fluorescence	Validated human kinase siRNA Set 2.0	Kinases	siRNA	p-value	Complex criteria
GR00143-A	2710		GK	GK s2	sp	none		no		tau phosphorylation	High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.	Azorsa et al.	2010	20067632	Cell line	H4 overexpressing 4RON tau	Total tau and 12E8 tau protein expression	Fluorescence	Validated human kinase siRNA Set 2.0	Kinases	siRNA	p-value	Complex criteria
GR00149-A-1	2710	2710	GK	24	82.06	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	2710	2710	GK	24	62.8	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	2710	2710	GK	25	-45.89	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	2710	2710	GK	25	-39.79	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	2710	2710	GK	103616	11.73	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	2710	2710	GK	103616	19.5	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00155-A	2710	2710	GK	GK_1, GK_2, GK_3	np	none		no		Aryl hydrocarbon receptor (AhR) transduction pathway regulation	RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity.	Gilot et al.	2011	21479225	Cell line	MCF-7	TCDD-induced CYP1A1-related EROD activity and cell viability	Fluorescence and methylene blue	MISSION siRNA Human Kinase Panel library	Kinases	siRNA	Z-score	Top 150 for >
GR00180-A-1	2710	2710	GK	PL-50001	0.476	none		no		Hepatitis C virus replication (1)	A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.	Tai et al.	2009	19286138	Cell line	Huh7/Rep-Feo	HCV replicon RNA copy number	Luminescence	siARRAY Human Genome siRNA Library	Genome-wide	siRNA	q-value	Complex criteria
GR00184-A-1	2710	NM_000167	GK	M-006727-00	-0.157238214769919	none		no		Self-renewal and pluripotency in human embryonic stem cells (1)	A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.	Chia et al.	2010	20953172	Cell line	hESC H1	POU5F1 protein expression	Fluorescence	SMARTpool siRNA library	Genome-wide	siRNA	Z-score	< -2
GR00197-A-1	2710	2710	GK	M-006727-00	0.051727891	none		no		Human papillomavirus oncogene expression regulation (1)	Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression.	Smith et al.	2010	20133580	Cell line	C33A/BE2/18LCR c4	HPV18 LCR reporter activity	Luminescence	Human siGENOME SMARTpool library	Genome-wide	siRNA	Z-score	>	Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5
GR00221-A-1	2710		GK	TRCN0000037635	-0.99	none		yes		Proliferation of cells with active beta-catenin (1)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MCF-7	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-1	2710		GK	TRCN0000037634	-0.25	none		yes		Proliferation of cells with active beta-catenin (1)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MCF-7	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-1	2710		GK	TRCN0000037637	1.07	none		yes		Proliferation of cells with active beta-catenin (1)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MCF-7	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-1	2710		GK	TRCN0000037638	1.13	none		yes		Proliferation of cells with active beta-catenin (1)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MCF-7	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-2	2710		GK	TRCN0000037635	-0.06	none		yes		Proliferation of cells with active beta-catenin (2)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-231	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-2	2710		GK	TRCN0000037637	0.35	none		yes		Proliferation of cells with active beta-catenin (2)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-231	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-2	2710		GK	TRCN0000037638	0.48	none		yes		Proliferation of cells with active beta-catenin (2)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-231	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-2	2710		GK	TRCN0000037634	1.41	none		yes		Proliferation of cells with active beta-catenin (2)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-231	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-3	2710		GK	TRCN0000037637	-0.48	none		yes		Proliferation of cells with active beta-catenin (3)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-453	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-3	2710		GK	TRCN0000037635	-0.34	none		yes		Proliferation of cells with active beta-catenin (3)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-453	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-3	2710		GK	TRCN0000037638	0.44	none		yes		Proliferation of cells with active beta-catenin (3)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-453	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-3	2710		GK	TRCN0000037634	0.6	none		yes		Proliferation of cells with active beta-catenin (3)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-453	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-4	2710		GK	TRCN0000037637	-0.32	none		no		Proliferation of cells with active beta-catenin (4)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	T47D	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-4	2710		GK	TRCN0000037638	-0.03	none		no		Proliferation of cells with active beta-catenin (4)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	T47D	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-4	2710		GK	TRCN0000037635	0.17	none		no		Proliferation of cells with active beta-catenin (4)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	T47D	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-4	2710		GK	TRCN0000037634	0.65	none		no		Proliferation of cells with active beta-catenin (4)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	T47D	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00225-A	2710		GK	GK_A	-0.480334	none	10nM gemcitabine	no		Combinatorial effect with gemcitabine	Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.	Azorsa et al.	2009	19519883	Cell line	MIAPaCa-2	Viability (synthetic lethal)	Luminescence	Validated kinase siRNA library version 1.0	Kinases	siRNA	log2 ratio	1.65 SD below mean ratio level
GR00225-A	2710		GK	GK_B	-0.408726	none	10nM gemcitabine	no		Combinatorial effect with gemcitabine	Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.	Azorsa et al.	2009	19519883	Cell line	MIAPaCa-2	Viability (synthetic lethal)	Luminescence	Validated kinase siRNA library version 1.0	Kinases	siRNA	log2 ratio	1.65 SD below mean ratio level
GR00225-A	2710		GK	GK_A	0.057579	none	5nM gemcitabine	no		Combinatorial effect with gemcitabine	Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.	Azorsa et al.	2009	19519883	Cell line	MIAPaCa-2	Viability (synthetic lethal)	Luminescence	Validated kinase siRNA library version 1.0	Kinases	siRNA	log2 ratio	1.65 SD below mean ratio level
GR00225-A	2710		GK	GK_B	-0.166851	none	5nM gemcitabine	no		Combinatorial effect with gemcitabine	Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.	Azorsa et al.	2009	19519883	Cell line	MIAPaCa-2	Viability (synthetic lethal)	Luminescence	Validated kinase siRNA library version 1.0	Kinases	siRNA	log2 ratio	1.65 SD below mean ratio level
	2710	NM_000167	GK	np	0.860605	none		no
GR00231-A	2710	NM_000167	GK	M-006727-00	0.438	none		yes		Cell proliferation	Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation.	Zhang et al.	2011	21765947	Cell line	HeLa	Viability	Electrical impedance	Human siARRAY - Protein Kinase and Cell Cycle libraries	Kinases and selected genes	siRNA	Z-score	< -1.96 OR > 1.96	Additional information about cell titer blue cell viability screen
GR00234-A-1	2710	NM_000167	GK	np	sp	none		no		Hepatitis C virus (HCV) infection (1)	EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.	Lupberger et al.	2011	21516087	Cell line	Huh7	Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) protein expression	Luminescence	Human Kinase RNAi Set V2.0	Kinases	siRNA	Complex, sp	Complex criteria
GR00236-A-1	2710	2710	GK	M-006727-00	1.33683583267079	none		no		Homologous recombination DNA double-strand break repair (HR-DSBR) (1)	A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.	Adamson et al.	2012	22344029	Cell line	DR-U2OS	(HR-DSBR) DR-GFP reporter and DNA content	Fluorescence	Human siGENOME siRNA (G-005000-05)	Genome-wide	siRNA	Relative HR ratio	< ~0.4 OR > 1.88	Cutoff values correspond 2 standard deviations from the screen-wide mean
GR00240-S-1	2710	NM_000167	GK	M-006727-00	-0.23	none		yes		TRAIL-induced apoptosis (1)	A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis.	Kranz and Boutros	2014	24442637	Cell line	U251MG	Viability	Luminescence	SMART-pool siRNA	Genome-wide	siRNA	Z-score	> 4	Author-submitted data
GR00240-S-2	2710	NM_000167	GK	M-006727-00	-0.07	none		no	Z-score -0.324	TRAIL-induced apoptosis (2)	A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis.	Kranz and Boutros	2014	24442637	Cell line	U251MG	Viability (synthetic lethal)	Luminescence	SMART-pool siRNA	Genome-wide	siRNA	Differential score	> 3.6 AND viability Z-score < 4	Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen.
GR00242-A-1	2710	NM_000167	GK	np	sp	none		no		Selective autophagy regulation (1)	Image-based genome-wide siRNA screen identifies selective autophagy factors.	Orvedahl et al.	2011	22020285	Cell line	HeLa/GFP-LC3	Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression	Fluorescence	siGenome	Genome-wide	siRNA	Z-score	Complex criteria
GR00247-A-1	2710		GK	np	sp	none			rank: 16912	Regulation of FOXO1 nuclear localization (1)	Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain.	Senapedis et al.	2011	21460183	Cell line	U2OS	EGFP-FOXO1a protein expression and DNA content	Fluorescence	Human Genome library	Genome-wide	siRNA	Complex, sp	Complex criteria
GR00248-A	2710	NM_000167	GK	GK_siRNA1	1	none				Human cytomegalovirus (HCMV) strain AD169 replication	Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.	Terry et al.	2012	22315427	Cell line	MRC5	Human cytomegalovirus (HCMV) IE1 protein expression	Fluorescence	Mission siRNA Human Kinase Panel	Kinases	siRNA	Z-score	>
GR00248-A	2710	NM_000167	GK	GK_siRNA2	2.081	Increased human cytomegalovirus (HCMV) strain AD169 replication				Human cytomegalovirus (HCMV) strain AD169 replication	Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.	Terry et al.	2012	22315427	Cell line	MRC5	Human cytomegalovirus (HCMV) IE1 protein expression	Fluorescence	Mission siRNA Human Kinase Panel	Kinases	siRNA	Z-score	>
GR00248-A	2710	NM_000167	GK	GK_siRNA3	0.149	none				Human cytomegalovirus (HCMV) strain AD169 replication	Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.	Terry et al.	2012	22315427	Cell line	MRC5	Human cytomegalovirus (HCMV) IE1 protein expression	Fluorescence	Mission siRNA Human Kinase Panel	Kinases	siRNA	Z-score	>
GR00249-S	2710	2710	GK	J-006727-07	-0.11257	none		no	number of cells compared to control (%): 97.96	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	2710	2710	GK	M-006727-00	-0.75883	none		no	number of cells compared to control (%): 54.59	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	2710	2710	GK	s223728	0.00015	none		no	number of cells compared to control (%): 91.24	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	2710	2710	GK	s5784	-0.8236	none		no	number of cells compared to control (%): 90.93	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	2710	2710	GK	s5785	0.02471	none		no	number of cells compared to control (%): 86.47	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00250-A-1	2710	2710	GK	M-006727-00	sp	Increased viability with MLN4924 (a NAE inhibitor)			duplicate screen, sextuplicate screen	Combinatorial effect with MLN4924, a NAE inhibitor (1)	Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.	Blank et al.	2013	23100467	Cell line	A375	Viability (synthetic lethal)	Luminescence	np	Genome-wide	siRNA	Complex, sp	Complex criteria	Phenotypes for 650 nmol/L MLN4924. Additional information about screens with 250 nmol/L MLN4924.
GR00250-A-2	2710	2710	GK	D-006727-01	sp	Increased viability with MLN4924 (a NAE inhibitor)			duplicate screen	Combinatorial effect with MLN4924, a NAE inhibitor (2)	Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.	Blank et al.	2013	23100467	Cell line	A375	Viability (synthetic lethal)	Luminescence	np	Selected genes	siRNA	Complex, sp	Complex criteria	Phenotypes for 650 nmol/L MLN4924. Additional information about screens with 250 nmol/L MLN4924.
GR00250-A-2	2710	2710	GK	D-006727-02	sp	Increased viability with MLN4924 (a NAE inhibitor)			duplicate screen	Combinatorial effect with MLN4924, a NAE inhibitor (2)	Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.	Blank et al.	2013	23100467	Cell line	A375	Viability (synthetic lethal)	Luminescence	np	Selected genes	siRNA	Complex, sp	Complex criteria	Phenotypes for 650 nmol/L MLN4924. Additional information about screens with 250 nmol/L MLN4924.
GR00250-A-2	2710	2710	GK	D-006727-03	sp	Increased viability with MLN4924 (a NAE inhibitor)			duplicate screen	Combinatorial effect with MLN4924, a NAE inhibitor (2)	Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.	Blank et al.	2013	23100467	Cell line	A375	Viability (synthetic lethal)	Luminescence	np	Selected genes	siRNA	Complex, sp	Complex criteria	Phenotypes for 650 nmol/L MLN4924. Additional information about screens with 250 nmol/L MLN4924.
GR00250-A-2	2710	2710	GK	D-006727-04	sp	none			duplicate screen	Combinatorial effect with MLN4924, a NAE inhibitor (2)	Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.	Blank et al.	2013	23100467	Cell line	A375	Viability (synthetic lethal)	Luminescence	np	Selected genes	siRNA	Complex, sp	Complex criteria	Phenotypes for 650 nmol/L MLN4924. Additional information about screens with 250 nmol/L MLN4924.
GR00253-A	2710	NM_000167	GK	np	-0.552	none				hepcidin regulation	Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.	Mleczko-Sanecka et al.	2014	24385536	Cell line	Huh7	hepcidin::fluc mRNA expression	Luminescence	siGenome siARRAY SMARTpool	Genome-wide	siRNA	Z-score	>	Cutoff <
GR00255-A-1	2710	2710	GK	TRCN0000037634, TRCN0000037635, TRCN0000037636, TRCN0000037637, TRCN0000037638	0.885737181	none				Negative genetic interactions (1)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -1.0	HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-2	2710	2710	GK	TRCN0000037634, TRCN0000037635, TRCN0000037636, TRCN0000037637, TRCN0000037638	1.499170582	none				Negative genetic interactions (2)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -1.0	HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-3	2710	2710	GK	TRCN0000037634, TRCN0000037635, TRCN0000037636, TRCN0000037637, TRCN0000037638	0.640909444	none				Negative genetic interactions (3)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -1.2	HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-4	2710	2710	GK	TRCN0000037634, TRCN0000037635, TRCN0000037636, TRCN0000037637, TRCN0000037638	0.414496098	none				Negative genetic interactions (4)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -1.2	HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-5	2710	2710	GK	TRCN0000037634, TRCN0000037635, TRCN0000037636, TRCN0000037637, TRCN0000037638	-0.328511047	none				Negative genetic interactions (5)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -0.8	HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00256-A	2710	NM_000167, NM_203391	GCKR	np	sp	none				Kinase-mediated spindle orientation	ABL1 regulates spindle orientation in adherent cells and mammalian skin.	Matsumara et al.	2012	22252550	Cell line	HeLa	beta-tubulin protein expression and DNA content	Fluorescence	Silencer Kinase siRNA library (AM80010V3)	Kinases	siRNA	Complex, sp	Complex criteria	HeLa cells stably expressing GFP-H2B (HeLa-GH2B) used. Additional information about secondary screens.
GR00293-A	2710		GK	np	-0.309	none				Combinatorial effect with paclitaxel	Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death	Sinnott et al.	2014	24860162	Cell line	HCC366	Viability	Luminescence	Thermo-Fisher	Genome-wide	siRNA	Z-score	< -2.5	Final hits according to the author are indicated in the comment.
GR00297-A	2710		GK	TRCN0000196599	0.35	none				Glucose limitation response	Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides	Birsoy et al.	2014	24670634	Cell line	Jurkat	shRNA abundance in high and low glucose	Deep sequencing	TRC	Selected genes	shRNA	Log2 ratio	< -0.75
GR00297-A	2710		GK	TRCN0000196319	3.27	none				Glucose limitation response	Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides	Birsoy et al.	2014	24670634	Cell line	Jurkat	shRNA abundance in high and low glucose	Deep sequencing	TRC	Selected genes	shRNA	Log2 ratio	< -0.75
GR00297-A	2710		GK	TRCN0000196700	0.74	none				Glucose limitation response	Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides	Birsoy et al.	2014	24670634	Cell line	Jurkat	shRNA abundance in high and low glucose	Deep sequencing	TRC	Selected genes	shRNA	Log2 ratio	< -0.75
GR00297-A	2710		GK	TRCN0000037638	-0.4	none				Glucose limitation response	Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides	Birsoy et al.	2014	24670634	Cell line	Jurkat	shRNA abundance in high and low glucose	Deep sequencing	TRC	Selected genes	shRNA	Log2 ratio	< -0.75
GR00297-A	2710		GK	TRCN0000195024	0	none				Glucose limitation response	Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides	Birsoy et al.	2014	24670634	Cell line	Jurkat	shRNA abundance in high and low glucose	Deep sequencing	TRC	Selected genes	shRNA	Log2 ratio	< -0.75
GR00297-A	2710		GK	TRCN0000195040	-0.13	none				Glucose limitation response	Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides	Birsoy et al.	2014	24670634	Cell line	Jurkat	shRNA abundance in high and low glucose	Deep sequencing	TRC	Selected genes	shRNA	Log2 ratio	< -0.75
GR00297-A	2710		GK	TRCN0000037636	0.21	none				Glucose limitation response	Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides	Birsoy et al.	2014	24670634	Cell line	Jurkat	shRNA abundance in high and low glucose	Deep sequencing	TRC	Selected genes	shRNA	Log2 ratio	< -0.75
GR00297-A	2710		GK	TRCN0000037635	-1.38	Decreased shRNA abundance				Glucose limitation response	Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides	Birsoy et al.	2014	24670634	Cell line	Jurkat	shRNA abundance in high and low glucose	Deep sequencing	TRC	Selected genes	shRNA	Log2 ratio	< -0.75
GR00297-A	2710		GK	TRCN0000037637	-0.21	none				Glucose limitation response	Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides	Birsoy et al.	2014	24670634	Cell line	Jurkat	shRNA abundance in high and low glucose	Deep sequencing	TRC	Selected genes	shRNA	Log2 ratio	< -0.75
GR00297-A	2710		GK	TRCN0000037634	-0.64	none				Glucose limitation response	Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides	Birsoy et al.	2014	24670634	Cell line	Jurkat	shRNA abundance in high and low glucose	Deep sequencing	TRC	Selected genes	shRNA	Log2 ratio	< -0.75
GR00300-A	2710		GK	TRCN0000195040, TRCN0000037636, TRCN0000037637, TRCN0000037634, TRCN0000037635, TRCN0000196700, TRCN0000195024, TRCN0000196599, TRCN0000196319, TRCN0000037638	0	none				Combinatorial effect with RAF inhibitor PLX4720	A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.	Whittaker et al.	2013	23288408	Cell line	A375	shRNA abundance	Sequencing	TRC	Genome-wide	shRNA	Number of shRNAs ranked Top1000	> 2	The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors.
GR00303-A	2710	NM_000167	GK	np	1.15	none				Clear cell renal cell carcinoma (ccRCC) survival regulation	Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target	Gerlinger et al.	2012	22362593	Cell line	VHL-deficient RCC4	Proliferation and Viability	Fluorescence	np	Genome-wide	siRNA	Z-score	<	In the phenotype data duplicates were in the original document, which have been removed.
GR00310-A-1	2710	2710	GK	np	0.13	none				Sindbis virus (SINV) infection (1)	Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry	Ooi et al.	2013	24367265	Cell line	U2OS	Sindbis virus (SINV) reporter	Luminescence	Ambion Silencer V3	Genome-wide	siRNA	Z-score	< -3 OR > 2
	2710	2710	GK	np	58	none			78,6% viability
GR00313-A	2710	NM_000167, NM_203391	GK	np	-0.28	none				TNF-alpha pathway regulation	A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling.	Nickles et al.	2012	22733992	Cell line	HEK293T	NFkappaB pathway reporter	Luminescence	Qiagen	Genome-wide	siRNA	Z-score	<	Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%.
GR00318-A	2710	2710	GK	np	1.573	none			siRNA set: kinase	Huntingtin toxicity	A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease	Miller et al.	2012	23209424	Cell line	HEK293T	Caspase 3/7 activity	Fluorescence	Dharmacon	Selected genes	siRNA	Sum of normalized caspase 3/7 activity mean and standard error	< 0.683	HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP).
GR00327-A	2710	2710	DCXR	CLL-H-007815	-0.5552256681767171	none				Tumor formation	An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation	Wolf et al.	2013	24292671	Cell line	SUM-149	shRNA abundance	Next-generation sequencing	Decipher library module 1	Selected genes	shRNA	Z-score	> 2.24	Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A	2710	2710	DCXR	CLL-H-007818	0.1254034923678322	none				Tumor formation	An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation	Wolf et al.	2013	24292671	Cell line	SUM-149	shRNA abundance	Next-generation sequencing	Decipher library module 1	Selected genes	shRNA	Z-score	> 2.24	Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A	2710	2710	DCXR	CLL-H-007819	-1.6201355262255503	none				Tumor formation	An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation	Wolf et al.	2013	24292671	Cell line	SUM-149	shRNA abundance	Next-generation sequencing	Decipher library module 1	Selected genes	shRNA	Z-score	> 2.24	Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A	2710	2710	DCXR	CLL-H-007816	-0.8802626672367007	none				Tumor formation	An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation	Wolf et al.	2013	24292671	Cell line	SUM-149	shRNA abundance	Next-generation sequencing	Decipher library module 1	Selected genes	shRNA	Z-score	> 2.24	Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A	2710	2710	DCXR	CLL-H-007817	np	none				Tumor formation	An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation	Wolf et al.	2013	24292671	Cell line	SUM-149	shRNA abundance	Next-generation sequencing	Decipher library module 1	Selected genes	shRNA	Z-score	> 2.24	Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00342-S-1	2710		GK	M-006727-00	0.40420048545244514	none				Viability of Mesenchymal Stem Cells (MSC) (1)	Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening	Erdmann et al.	2015	26120366	Primary cells	Bone marrow derived MSC	Viability	Luminescence	Kinase siGENOME SMARTpool library	Kinases and phosphatases	siRNA	Z-score	>	Donor 1, MSC preparation 1 (MSC1a)
GR00342-S-2	2710		GK	M-006727-00	-0.36286734778823654	none				Viability of Mesenchymal Stem Cells (MSC) (2)	Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening	Erdmann et al.	2015	26120366	Primary cells	Bone marrow derived MSC	Viability	Luminescence	Kinase siGENOME SMARTpool library	Kinases and phosphatases	siRNA	Z-score	>	Donor 1, MSC preparation 2 (MSC1b)
GR00342-S-3	2710		GK	M-006727-00	-0.6467836104404954	none				Viability of Mesenchymal Stem Cells (MSC) (3)	Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening	Erdmann et al.	2015	26120366	Primary cells	Bone marrow derived MSC	Viability	Luminescence	Kinase siGENOME SMARTpool library	Kinases and phosphatases	siRNA	Z-score	>	Donor 2, MSC preparation 1 (MSC2)
GR00343-S	2710	2710	GK	TRCN0000037634	0.9650000000000016	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	2710	2710	GK	TRCN0000037635	1.067499999999999	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	2710	2710	GK	TRCN0000037637	1.4849999999999994	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	2710	2710	GK	TRCN0000037638	-0.02999999999999936	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	2710	2710	GK	TRCN0000037636	0.40249999999999986	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00356-A-1	2710	NM_000167	GK	np	0.34	none				Clathrin-mediated endocytosis	Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis.	Pelkmans et al.	2005	15889048	Cell line	HeLa	Vesicular stomatitis virus (VSV) infection (rVSV–GFP expression)	Fluorescence	Ambion	Kinases	siRNA	Relative infection index (RII)	<	The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Caveolin- and lipid raft-mediated endocytosis" using simian virus 40 (SV40).
GR00356-A-2	2710	NM_000167	GK	np	1.907602614333851	none				Caveolin- and lipid raft-mediated endocytosis	Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis.	Pelkmans et al.	2005	15889048	Cell line	HeLa	Simian virus 40 (SV40) infection (SV40 large T-antigen expression)	Fluorescence	Ambion	Kinases	siRNA	Relative infection index (RII)	<	The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Clathrin-mediated endocytosis" using vesicular stomatitis virus (VSV).
GR00356-A-3	2710	NM_000167	GK	np	np	none				Endocytosis regulation	Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis.	Pelkmans et al.	2005	15889048	Cell line	HeLa	Transferrin (Tfn) uptake and trafficking	Fluorescence	Ambion	Kinases	siRNA	np	np
GR00363-A	2710	2710	GK	SI03109106, SI00604793, SI00604786, SI00003563, 24, 25, 103562	sp	Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)			strong	Endocytosis regulation	Systems survey of endocytosis by multiparametric image analysis.	Collinet et al.	2010	20190736	Cell line	HeLa	Transferrin (TF) and epidermal growth factor (EGF) subcellular localisation, DNA content	Fluorescence	Ambion, Qiagen and esiRNA library (Kittler et al.)	Genome-wide	siRNA	Complex, sp	Complex criteria	Two hit categories: "strong" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn > 0.95) and "weak but specific" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn < 0.95 but Phenoscore > 0.95). Additional information about secondary screens with kinase and phospatase libraries.
GR00366-A-1	2710		GK	TRCN0000037634, TRCN0000037635	-0.50020054903151	none			GK_1_111101	Context-specific genetic dependencies (1)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	22RV1_PROSTATE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-10	2710		GK	TRCN0000037634, TRCN0000037635	-0.796472331178234	none			GK_1_111101	Context-specific genetic dependencies (10)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	ACHN_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-100	2710		GK	TRCN0000037634, TRCN0000037635	-0.029566099872531	none			GK_1_111101	Context-specific genetic dependencies (100)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-101	2710		GK	TRCN0000037634, TRCN0000037635	0.278629671624082	none			GK_1_111101	Context-specific genetic dependencies (101)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LK2_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-102	2710		GK	TRCN0000037634, TRCN0000037635	1.27593428538901	Increased shRNA abundance (Z-score > 2)			GK_1_111101	Context-specific genetic dependencies (102)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN215_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-103	2710		GK	TRCN0000037634, TRCN0000037635	0.58700085104081	none			GK_1_111101	Context-specific genetic dependencies (103)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN229_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-104	2710		GK	TRCN0000037634, TRCN0000037635	-0.167642036637756	none			GK_1_111101	Context-specific genetic dependencies (104)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN235_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-105	2710		GK	TRCN0000037634, TRCN0000037635	1.8017843941758	Increased shRNA abundance (Z-score > 2)			GK_1_111101	Context-specific genetic dependencies (105)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN319_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-106	2710		GK	TRCN0000037634, TRCN0000037635	-0.23919107903227	none			GK_1_111101	Context-specific genetic dependencies (106)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN340_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-107	2710		GK	TRCN0000037634, TRCN0000037635	0.693579587303231	none			GK_1_111101	Context-specific genetic dependencies (107)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN382_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-108	2710		GK	TRCN0000037634, TRCN0000037635	-0.486544090050096	none			GK_1_111101	Context-specific genetic dependencies (108)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN428_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-109	2710		GK	TRCN0000037634, TRCN0000037635	-0.0660480216656044	none			GK_1_111101	Context-specific genetic dependencies (109)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN443_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-11	2710		GK	TRCN0000037634, TRCN0000037635	1.23779777835284	Increased shRNA abundance (Z-score > 2)			GK_1_111101	Context-specific genetic dependencies (11)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	AGS_STOMACH	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-110	2710		GK	TRCN0000037634, TRCN0000037635	0.137249024831188	none			GK_1_111101	Context-specific genetic dependencies (110)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN464_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-111	2710		GK	TRCN0000037634, TRCN0000037635	0.498146678619284	none			GK_1_111101	Context-specific genetic dependencies (111)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LNZ308_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-112	2710		GK	TRCN0000037634, TRCN0000037635	0.0534850735839783	none			GK_1_111101	Context-specific genetic dependencies (112)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LOVO_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-113	2710		GK	TRCN0000037634, TRCN0000037635	0.648360170943318	none			GK_1_111101	Context-specific genetic dependencies (113)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LS411N_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-114	2710		GK	TRCN0000037634, TRCN0000037635	0.480464902355104	none			GK_1_111101	Context-specific genetic dependencies (114)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LS513_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-115	2710		GK	TRCN0000037634, TRCN0000037635	-0.480490352102471	none			GK_1_111101	Context-specific genetic dependencies (115)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MCF7_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-116	2710		GK	TRCN0000037634, TRCN0000037635	-0.527939794565639	none			GK_1_111101	Context-specific genetic dependencies (116)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MDAMB453_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-117	2710		GK	TRCN0000037634, TRCN0000037635	-0.369839975331058	none			GK_1_111101	Context-specific genetic dependencies (117)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MIAPACA2_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-118	2710		GK	TRCN0000037634, TRCN0000037635	0.496687111135808	none			GK_1_111101	Context-specific genetic dependencies (118)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MKN7_STOMACH	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-119	2710		GK	TRCN0000037634, TRCN0000037635	0.182109538044468	none			GK_1_111101	Context-specific genetic dependencies (119)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-12	2710		GK	TRCN0000037634, TRCN0000037635	0.407121872779205	none			GK_1_111101	Context-specific genetic dependencies (12)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	AM38_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-120	2710		GK	TRCN0000037634, TRCN0000037635	-0.00193778741159099	none			GK_1_111101	Context-specific genetic dependencies (120)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-121	2710		GK	TRCN0000037634, TRCN0000037635	0.18852024929134	none			GK_1_111101	Context-specific genetic dependencies (121)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-122	2710		GK	TRCN0000037634, TRCN0000037635	0.109089427627636	none			GK_1_111101	Context-specific genetic dependencies (122)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-123	2710		GK	TRCN0000037634, TRCN0000037635	-0.275843915597217	none			GK_1_111101	Context-specific genetic dependencies (123)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-124	2710		GK	TRCN0000037634, TRCN0000037635	0.827183526565812	none			GK_1_111101	Context-specific genetic dependencies (124)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-125	2710		GK	TRCN0000037634, TRCN0000037635	0.767007641871968	none			GK_1_111101	Context-specific genetic dependencies (125)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-126	2710		GK	TRCN0000037634, TRCN0000037635	-0.599509045718575	none			GK_1_111101	Context-specific genetic dependencies (126)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1299_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-127	2710		GK	TRCN0000037634, TRCN0000037635	-0.794714144337092	none			GK_1_111101	Context-specific genetic dependencies (127)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1437_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-128	2710		GK	TRCN0000037634, TRCN0000037635	-0.50191184431033	none			GK_1_111101	Context-specific genetic dependencies (128)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1650_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-129	2710		GK	TRCN0000037634, TRCN0000037635	0.37577990404289	none			GK_1_111101	Context-specific genetic dependencies (129)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1792_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-13	2710		GK	TRCN0000037634, TRCN0000037635	0.985346842686951	none			GK_1_111101	Context-specific genetic dependencies (13)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-130	2710		GK	TRCN0000037634, TRCN0000037635	-0.0639622409814519	none			GK_1_111101	Context-specific genetic dependencies (130)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH196_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-131	2710		GK	TRCN0000037634, TRCN0000037635	0.117065678066001	none			GK_1_111101	Context-specific genetic dependencies (131)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1975_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-132	2710		GK	TRCN0000037634, TRCN0000037635	-0.825357983288648	none			GK_1_111101	Context-specific genetic dependencies (132)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH2052_PLEURA	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-133	2710		GK	TRCN0000037634, TRCN0000037635	0.51224386351627	none			GK_1_111101	Context-specific genetic dependencies (133)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH2122_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-134	2710		GK	TRCN0000037634, TRCN0000037635	-0.846649848717432	none			GK_1_111101	Context-specific genetic dependencies (134)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH2171_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-135	2710		GK	TRCN0000037634, TRCN0000037635	0.862489597475604	none			GK_1_111101	Context-specific genetic dependencies (135)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH23_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-136	2710		GK	TRCN0000037634, TRCN0000037635	-0.431383779201913	none			GK_1_111101	Context-specific genetic dependencies (136)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH2452_PLEURA	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-137	2710		GK	TRCN0000037634, TRCN0000037635	-0.229271626072447	none			GK_1_111101	Context-specific genetic dependencies (137)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH441_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-138	2710		GK	TRCN0000037634, TRCN0000037635	1.00579557092464	none			GK_1_111101	Context-specific genetic dependencies (138)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH508_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-139	2710		GK	TRCN0000037634, TRCN0000037635	0.279661081416243	none			GK_1_111101	Context-specific genetic dependencies (139)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH660_PROSTATE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-14	2710		GK	TRCN0000037634, TRCN0000037635	-0.328114424694367	none			GK_1_111101	Context-specific genetic dependencies (14)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	ASPC1_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-140	2710		GK	TRCN0000037634, TRCN0000037635	-0.398522639134998	none			GK_1_111101	Context-specific genetic dependencies (140)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH661_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-141	2710		GK	TRCN0000037634, TRCN0000037635	-0.691128125276006	none			GK_1_111101	Context-specific genetic dependencies (141)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH716_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-142	2710		GK	TRCN0000037634, TRCN0000037635	-1.35706112470612	Decreased shRNA abundance (Z-score < -2)			GK_1_111101	Context-specific genetic dependencies (142)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH838_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-143	2710		GK	TRCN0000037634, TRCN0000037635	0.573806724657819	none			GK_1_111101	Context-specific genetic dependencies (143)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIN87_STOMACH	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-144	2710		GK	TRCN0000037634, TRCN0000037635	-0.832494974746675	none			GK_1_111101	Context-specific genetic dependencies (144)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NIHOVCAR3_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-145	2710		GK	TRCN0000037634, TRCN0000037635	0.665966570988937	none			GK_1_111101	Context-specific genetic dependencies (145)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-146	2710		GK	TRCN0000037634, TRCN0000037635	-0.387433043722214	none			GK_1_111101	Context-specific genetic dependencies (146)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OAW42_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-147	2710		GK	TRCN0000037634, TRCN0000037635	0.654581200932808	none			GK_1_111101	Context-specific genetic dependencies (147)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-148	2710		GK	TRCN0000037634, TRCN0000037635	1.16165150732304	none			GK_1_111101	Context-specific genetic dependencies (148)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-149	2710		GK	TRCN0000037634, TRCN0000037635	0.845873939377107	none			GK_1_111101	Context-specific genetic dependencies (149)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-15	2710		GK	TRCN0000037634, TRCN0000037635	-0.182387229811668	none			GK_1_111101	Context-specific genetic dependencies (15)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	BT20_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-150	2710		GK	TRCN0000037634, TRCN0000037635	0.313515662359633	none			GK_1_111101	Context-specific genetic dependencies (150)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OE33_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-151	2710		GK	TRCN0000037634, TRCN0000037635	-0.991846814939774	none			GK_1_111101	Context-specific genetic dependencies (151)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OELE_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-152	2710		GK	TRCN0000037634, TRCN0000037635	0.597180448400788	none			GK_1_111101	Context-specific genetic dependencies (152)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-153	2710		GK	TRCN0000037634, TRCN0000037635	-0.532210999704225	none			GK_1_111101	Context-specific genetic dependencies (153)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OV7_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-154	2710		GK	TRCN0000037634, TRCN0000037635	0.2223249542994	none			GK_1_111101	Context-specific genetic dependencies (154)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OV90_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-155	2710		GK	TRCN0000037634, TRCN0000037635	-0.20468357988391	none			GK_1_111101	Context-specific genetic dependencies (155)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OVCAR4_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-156	2710		GK	TRCN0000037634, TRCN0000037635	0.0460192637131106	none			GK_1_111101	Context-specific genetic dependencies (156)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OVCAR8_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-157	2710		GK	TRCN0000037634, TRCN0000037635	-0.390711493925266	none			GK_1_111101	Context-specific genetic dependencies (157)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OVISE_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-158	2710		GK	TRCN0000037634, TRCN0000037635	0.132968081103194	none			GK_1_111101	Context-specific genetic dependencies (158)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PANC0327_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-159	2710		GK	TRCN0000037634, TRCN0000037635	-0.411464262163283	none			GK_1_111101	Context-specific genetic dependencies (159)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PANC0813_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-16	2710		GK	TRCN0000037634, TRCN0000037635	-0.223746500660205	none			GK_1_111101	Context-specific genetic dependencies (16)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	BT474_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-160	2710		GK	TRCN0000037634, TRCN0000037635	0.910585146918649	none			GK_1_111101	Context-specific genetic dependencies (160)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PANC1005_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-161	2710		GK	TRCN0000037634, TRCN0000037635	0.608446857969302	none			GK_1_111101	Context-specific genetic dependencies (161)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-162	2710		GK	TRCN0000037634, TRCN0000037635	-1.20973028224654	Decreased shRNA abundance (Z-score < -2)			GK_1_111101	Context-specific genetic dependencies (162)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PSN1_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-163	2710		GK	TRCN0000037634, TRCN0000037635	-0.68928560256164	none			GK_1_111101	Context-specific genetic dependencies (163)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	QGP1_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-164	2710		GK	TRCN0000037634, TRCN0000037635	1.04459607449431	none			GK_1_111101	Context-specific genetic dependencies (164)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-165	2710		GK	TRCN0000037634, TRCN0000037635	0.673081289460193	none			GK_1_111101	Context-specific genetic dependencies (165)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RKN_SOFT_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-166	2710		GK	TRCN0000037634, TRCN0000037635	0.589508508203103	none			GK_1_111101	Context-specific genetic dependencies (166)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RKO_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-167	2710		GK	TRCN0000037634, TRCN0000037635	-0.638734876411908	none			GK_1_111101	Context-specific genetic dependencies (167)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RMGI_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-168	2710		GK	TRCN0000037634, TRCN0000037635	-0.240440412458422	none			GK_1_111101	Context-specific genetic dependencies (168)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RMUGS_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-169	2710		GK	TRCN0000037634, TRCN0000037635	0.348879583766336	none			GK_1_111101	Context-specific genetic dependencies (169)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-17	2710		GK	TRCN0000037634, TRCN0000037635	-0.184730219914896	none			GK_1_111101	Context-specific genetic dependencies (17)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	BXPC3_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-170	2710		GK	TRCN0000037634, TRCN0000037635	-0.011913329446259	none			GK_1_111101	Context-specific genetic dependencies (170)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RT112_URINARY_TRACT	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-171	2710		GK	TRCN0000037634, TRCN0000037635	0.39819024537018	none			GK_1_111101	Context-specific genetic dependencies (171)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-172	2710		GK	TRCN0000037634, TRCN0000037635	-0.547161866250977	none			GK_1_111101	Context-specific genetic dependencies (172)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SF126_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-173	2710		GK	TRCN0000037634, TRCN0000037635	-0.824589725716686	none			GK_1_111101	Context-specific genetic dependencies (173)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SF172_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-174	2710		GK	TRCN0000037634, TRCN0000037635	-0.865070316342501	none			GK_1_111101	Context-specific genetic dependencies (174)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SF295_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-175	2710		GK	TRCN0000037634, TRCN0000037635	-0.239446902103929	none			GK_1_111101	Context-specific genetic dependencies (175)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SF767_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-176	2710		GK	TRCN0000037634, TRCN0000037635	-0.626519529815806	none			GK_1_111101	Context-specific genetic dependencies (176)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SJSA1_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-177	2710		GK	TRCN0000037634, TRCN0000037635	0.352231123601432	none			GK_1_111101	Context-specific genetic dependencies (177)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKCO1_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-178	2710		GK	TRCN0000037634, TRCN0000037635	0.205868269537108	none			GK_1_111101	Context-specific genetic dependencies (178)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKMEL5_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-179	2710		GK	TRCN0000037634, TRCN0000037635	0.443464391790414	none			GK_1_111101	Context-specific genetic dependencies (179)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-18	2710		GK	TRCN0000037634, TRCN0000037635	0.344794693513749	none			GK_1_111101	Context-specific genetic dependencies (18)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	C2BBE1_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-180	2710		GK	TRCN0000037634, TRCN0000037635	1.24847059054362	Increased shRNA abundance (Z-score > 2)			GK_1_111101	Context-specific genetic dependencies (180)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-181	2710		GK	TRCN0000037634, TRCN0000037635	-0.810039791299636	none			GK_1_111101	Context-specific genetic dependencies (181)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKOV3_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-182	2710		GK	TRCN0000037634, TRCN0000037635	-0.196754839334346	none			GK_1_111101	Context-specific genetic dependencies (182)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKRC20_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-183	2710		GK	TRCN0000037634, TRCN0000037635	0.00751004134380254	none			GK_1_111101	Context-specific genetic dependencies (183)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR20_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-184	2710		GK	TRCN0000037634, TRCN0000037635	-0.620500179672182	none			GK_1_111101	Context-specific genetic dependencies (184)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR21_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-185	2710		GK	TRCN0000037634, TRCN0000037635	-0.55128687461425	none			GK_1_111101	Context-specific genetic dependencies (185)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR23_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-186	2710		GK	TRCN0000037634, TRCN0000037635	-0.229306717370926	none			GK_1_111101	Context-specific genetic dependencies (186)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR24_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-187	2710		GK	TRCN0000037634, TRCN0000037635	-0.291760776191544	none			GK_1_111101	Context-specific genetic dependencies (187)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR25_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-188	2710		GK	TRCN0000037634, TRCN0000037635	-0.0262737404217889	none			GK_1_111101	Context-specific genetic dependencies (188)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR26_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-189	2710		GK	TRCN0000037634, TRCN0000037635	0.22754181869895	none			GK_1_111101	Context-specific genetic dependencies (189)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SNU1105_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-19	2710		GK	TRCN0000037634, TRCN0000037635	0.643231949689496	none			GK_1_111101	Context-specific genetic dependencies (19)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	C32_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-190	2710		GK	TRCN0000037634, TRCN0000037635	-0.765528385114708	none			GK_1_111101	Context-specific genetic dependencies (190)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SNU840_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-191	2710		GK	TRCN0000037634, TRCN0000037635	0.222375302430956	none			GK_1_111101	Context-specific genetic dependencies (191)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SNUC1_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-192	2710		GK	TRCN0000037634, TRCN0000037635	-0.057916617006402	none			GK_1_111101	Context-specific genetic dependencies (192)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SNUC2A_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-193	2710		GK	TRCN0000037634, TRCN0000037635	-0.752056864649399	none			GK_1_111101	Context-specific genetic dependencies (193)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SU8686_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-194	2710		GK	TRCN0000037634, TRCN0000037635	-0.0228293283567802	none			GK_1_111101	Context-specific genetic dependencies (194)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SW1417_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-195	2710		GK	TRCN0000037634, TRCN0000037635	0.413079214900728	none			GK_1_111101	Context-specific genetic dependencies (195)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SW1783_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-196	2710		GK	TRCN0000037634, TRCN0000037635	-0.594686209658427	none			GK_1_111101	Context-specific genetic dependencies (196)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SW480_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-197	2710		GK	TRCN0000037634, TRCN0000037635	-0.0993421450491419	none			GK_1_111101	Context-specific genetic dependencies (197)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SW48_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-198	2710		GK	TRCN0000037634, TRCN0000037635	0.922523205880559	none			GK_1_111101	Context-specific genetic dependencies (198)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	T98G_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-199	2710		GK	TRCN0000037634, TRCN0000037635	0.380921523613943	none			GK_1_111101	Context-specific genetic dependencies (199)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TC71_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-2	2710		GK	TRCN0000037634, TRCN0000037635	0.251941300780426	none			GK_1_111101	Context-specific genetic dependencies (2)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-20	2710		GK	TRCN0000037634, TRCN0000037635	1.11965171477509	none			GK_1_111101	Context-specific genetic dependencies (20)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CADOES1_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-200	2710		GK	TRCN0000037634, TRCN0000037635	-0.102143945378084	none			GK_1_111101	Context-specific genetic dependencies (200)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TCCSUP_URINARY_TRACT	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-201	2710		GK	TRCN0000037634, TRCN0000037635	0.107970545313816	none			GK_1_111101	Context-specific genetic dependencies (201)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TE10_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-202	2710		GK	TRCN0000037634, TRCN0000037635	-0.507553205542837	none			GK_1_111101	Context-specific genetic dependencies (202)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TE15_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-203	2710		GK	TRCN0000037634, TRCN0000037635	-0.315544535713778	none			GK_1_111101	Context-specific genetic dependencies (203)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TE9_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-204	2710		GK	TRCN0000037634, TRCN0000037635	0.901787481204563	none			GK_1_111101	Context-specific genetic dependencies (204)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-205	2710		GK	TRCN0000037634, TRCN0000037635	0.417042853769476	none			GK_1_111101	Context-specific genetic dependencies (205)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TOV112D_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-206	2710		GK	TRCN0000037634, TRCN0000037635	-0.459149936536388	none			GK_1_111101	Context-specific genetic dependencies (206)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TOV21G_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-207	2710		GK	TRCN0000037634, TRCN0000037635	-0.383512395222169	none			GK_1_111101	Context-specific genetic dependencies (207)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TT_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-208	2710		GK	TRCN0000037634, TRCN0000037635	-0.310380457176543	none			GK_1_111101	Context-specific genetic dependencies (208)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TYKNU_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-209	2710		GK	TRCN0000037634, TRCN0000037635	-0.241622264993579	none			GK_1_111101	Context-specific genetic dependencies (209)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	U178_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-21	2710		GK	TRCN0000037634, TRCN0000037635	-0.214136380299566	none			GK_1_111101	Context-specific genetic dependencies (21)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAL120_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-210	2710		GK	TRCN0000037634, TRCN0000037635	-0.342232865561351	none			GK_1_111101	Context-specific genetic dependencies (210)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	U251MG_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-211	2710		GK	TRCN0000037634, TRCN0000037635	-0.298404399709848	none			GK_1_111101	Context-specific genetic dependencies (211)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	U343_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-212	2710		GK	TRCN0000037634, TRCN0000037635	0.0615020749904533	none			GK_1_111101	Context-specific genetic dependencies (212)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	U87MG_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-213	2710		GK	TRCN0000037634, TRCN0000037635	0.451845152121545	none			GK_1_111101	Context-specific genetic dependencies (213)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	UOK101_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-214	2710		GK	TRCN0000037634, TRCN0000037635	-0.374053617490472	none			GK_1_111101	Context-specific genetic dependencies (214)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	VCAP_PROSTATE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-215	2710		GK	TRCN0000037634, TRCN0000037635	0.212881637780555	none			GK_1_111101	Context-specific genetic dependencies (215)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	YKG1_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-216	2710		GK	TRCN0000037634, TRCN0000037635	0.505435938971894	none			GK_1_111101	Context-specific genetic dependencies (216)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	ZR7530_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-22	2710		GK	TRCN0000037634, TRCN0000037635	-0.0700690371830398	none			GK_1_111101	Context-specific genetic dependencies (22)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAL51_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-23	2710		GK	TRCN0000037634, TRCN0000037635	-0.303118947655222	none			GK_1_111101	Context-specific genetic dependencies (23)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CALU1_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-24	2710		GK	TRCN0000037634, TRCN0000037635	0.183647995387727	none			GK_1_111101	Context-specific genetic dependencies (24)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAOV3_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-25	2710		GK	TRCN0000037634, TRCN0000037635	0.672513464172197	none			GK_1_111101	Context-specific genetic dependencies (25)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAOV4_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-26	2710		GK	TRCN0000037634, TRCN0000037635	-0.622507332596205	none			GK_1_111101	Context-specific genetic dependencies (26)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAS1_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-27	2710		GK	TRCN0000037634, TRCN0000037635	0.767578431797253	none			GK_1_111101	Context-specific genetic dependencies (27)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CFPAC1_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-28	2710		GK	TRCN0000037634, TRCN0000037635	0.51320423286809	none			GK_1_111101	Context-specific genetic dependencies (28)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CH157MN_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-29	2710		GK	TRCN0000037634, TRCN0000037635	-0.857575096322946	none			GK_1_111101	Context-specific genetic dependencies (29)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COLO205_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-3	2710		GK	TRCN0000037634, TRCN0000037635	0.944163024199458	none			GK_1_111101	Context-specific genetic dependencies (3)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	786O_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-30	2710		GK	TRCN0000037634, TRCN0000037635	1.48735955300964	Increased shRNA abundance (Z-score > 2)			GK_1_111101	Context-specific genetic dependencies (30)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COLO704_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-31	2710		GK	TRCN0000037634, TRCN0000037635	-0.301661954455013	none			GK_1_111101	Context-specific genetic dependencies (31)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COLO741_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-32	2710		GK	TRCN0000037634, TRCN0000037635	0.837650425216852	none			GK_1_111101	Context-specific genetic dependencies (32)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COLO783_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-33	2710		GK	TRCN0000037634, TRCN0000037635	0.252262272589141	none			GK_1_111101	Context-specific genetic dependencies (33)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CORL23_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-34	2710		GK	TRCN0000037634, TRCN0000037635	0.139219081723639	none			GK_1_111101	Context-specific genetic dependencies (34)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COV362_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-35	2710		GK	TRCN0000037634, TRCN0000037635	0.650326104897447	none			GK_1_111101	Context-specific genetic dependencies (35)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COV434_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-36	2710		GK	TRCN0000037634, TRCN0000037635	-0.0239565389807607	none			GK_1_111101	Context-specific genetic dependencies (36)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COV504_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-37	2710		GK	TRCN0000037634, TRCN0000037635	-0.21771083558772	none			GK_1_111101	Context-specific genetic dependencies (37)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COV644_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-38	2710		GK	TRCN0000037634, TRCN0000037635	-0.437129530879223	none			GK_1_111101	Context-specific genetic dependencies (38)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	DBTRG05MG_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-39	2710		GK	TRCN0000037634, TRCN0000037635	0.0766181185862849	none			GK_1_111101	Context-specific genetic dependencies (39)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	DKMG_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-4	2710		GK	TRCN0000037634, TRCN0000037635	0.4917803408785	none			GK_1_111101	Context-specific genetic dependencies (4)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A1207_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-40	2710		GK	TRCN0000037634, TRCN0000037635	1.11016642428666	none			GK_1_111101	Context-specific genetic dependencies (40)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	DLD1_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-41	2710		GK	TRCN0000037634, TRCN0000037635	-0.094027534938575	none			GK_1_111101	Context-specific genetic dependencies (41)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EFE184_ENDOMETRIUM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-42	2710		GK	TRCN0000037634, TRCN0000037635	1.20287838649079	none			GK_1_111101	Context-specific genetic dependencies (42)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EFM19_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-43	2710		GK	TRCN0000037634, TRCN0000037635	0.0381865380579374	none			GK_1_111101	Context-specific genetic dependencies (43)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EFO21_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-44	2710		GK	TRCN0000037634, TRCN0000037635	0.771836172782849	none			GK_1_111101	Context-specific genetic dependencies (44)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EFO27_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-45	2710		GK	TRCN0000037634, TRCN0000037635	-0.0442552972697676	none			GK_1_111101	Context-specific genetic dependencies (45)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EW8_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-46	2710		GK	TRCN0000037634, TRCN0000037635	-0.070045725751637	none			GK_1_111101	Context-specific genetic dependencies (46)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EWS502_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-47	2710		GK	TRCN0000037634, TRCN0000037635	0.00836284260727763	none			GK_1_111101	Context-specific genetic dependencies (47)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-48	2710		GK	TRCN0000037634, TRCN0000037635	-0.810450115004175	none			GK_1_111101	Context-specific genetic dependencies (48)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	GB1_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-49	2710		GK	TRCN0000037634, TRCN0000037635	0.157484786383697	none			GK_1_111101	Context-specific genetic dependencies (49)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	GP2D_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-5	2710		GK	TRCN0000037634, TRCN0000037635	0.973445735670381	none			GK_1_111101	Context-specific genetic dependencies (5)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A172_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-50	2710		GK	TRCN0000037634, TRCN0000037635	-0.722595410088554	none			GK_1_111101	Context-specific genetic dependencies (50)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC1187_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-51	2710		GK	TRCN0000037634, TRCN0000037635	-0.197337652805935	none			GK_1_111101	Context-specific genetic dependencies (51)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC1395_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-52	2710		GK	TRCN0000037634, TRCN0000037635	0.443221498362258	none			GK_1_111101	Context-specific genetic dependencies (52)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC1954_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-53	2710		GK	TRCN0000037634, TRCN0000037635	0.628246875504877	none			GK_1_111101	Context-specific genetic dependencies (53)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC2218_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-54	2710		GK	TRCN0000037634, TRCN0000037635	0.0547107516424587	none			GK_1_111101	Context-specific genetic dependencies (54)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC2814_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-55	2710		GK	TRCN0000037634, TRCN0000037635	0.761911660191676	none			GK_1_111101	Context-specific genetic dependencies (55)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC364_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-56	2710		GK	TRCN0000037634, TRCN0000037635	-0.577518528576988	none			GK_1_111101	Context-specific genetic dependencies (56)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC44_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-57	2710		GK	TRCN0000037634, TRCN0000037635	0.21659618158269	none			GK_1_111101	Context-specific genetic dependencies (57)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC70_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-58	2710		GK	TRCN0000037634, TRCN0000037635	0.374286165126456	none			GK_1_111101	Context-specific genetic dependencies (58)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC827GR5_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-59	2710		GK	TRCN0000037634, TRCN0000037635	-0.0478722333901836	none			GK_1_111101	Context-specific genetic dependencies (59)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC827_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-6	2710		GK	TRCN0000037634, TRCN0000037635	0.743144402262285	none			GK_1_111101	Context-specific genetic dependencies (6)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A204_SOFT_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-60	2710		GK	TRCN0000037634, TRCN0000037635	-0.439064507499164	none			GK_1_111101	Context-specific genetic dependencies (60)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCT116_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-61	2710		GK	TRCN0000037634, TRCN0000037635	-0.0403997806064416	none			GK_1_111101	Context-specific genetic dependencies (61)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HEC1A_ENDOMETRIUM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-62	2710		GK	TRCN0000037634, TRCN0000037635	-0.623289180679394	none			GK_1_111101	Context-specific genetic dependencies (62)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HEYA8_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-63	2710		GK	TRCN0000037634, TRCN0000037635	1.1273822483158	none			GK_1_111101	Context-specific genetic dependencies (63)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-64	2710		GK	TRCN0000037634, TRCN0000037635	-0.250574603624062	none			GK_1_111101	Context-specific genetic dependencies (64)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HLF_LIVER	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-65	2710		GK	TRCN0000037634, TRCN0000037635	0.53297032286472	none			GK_1_111101	Context-specific genetic dependencies (65)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-66	2710		GK	TRCN0000037634, TRCN0000037635	0.40921646160216	none			GK_1_111101	Context-specific genetic dependencies (66)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HPAC_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-67	2710		GK	TRCN0000037634, TRCN0000037635	-0.912540945174355	none			GK_1_111101	Context-specific genetic dependencies (67)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HPAFII_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-68	2710		GK	TRCN0000037634, TRCN0000037635	0.461421614559734	none			GK_1_111101	Context-specific genetic dependencies (68)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HS683_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-69	2710		GK	TRCN0000037634, TRCN0000037635	0.531152891280697	none			GK_1_111101	Context-specific genetic dependencies (69)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HS766T_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-7	2710		GK	TRCN0000037634, TRCN0000037635	-0.567060765682212	none			GK_1_111101	Context-specific genetic dependencies (7)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A2058_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-70	2710		GK	TRCN0000037634, TRCN0000037635	-0.371062403754634	none			GK_1_111101	Context-specific genetic dependencies (70)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HS944T_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-71	2710		GK	TRCN0000037634, TRCN0000037635	-0.00102659308139742	none			GK_1_111101	Context-specific genetic dependencies (71)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HT1197_URINARY_TRACT	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-72	2710		GK	TRCN0000037634, TRCN0000037635	-0.0255048189950449	none			GK_1_111101	Context-specific genetic dependencies (72)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HT29_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-73	2710		GK	TRCN0000037634, TRCN0000037635	0.0751464773217916	none			GK_1_111101	Context-specific genetic dependencies (73)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HT55_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-74	2710		GK	TRCN0000037634, TRCN0000037635	-0.397964794008732	none			GK_1_111101	Context-specific genetic dependencies (74)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HUG1N_STOMACH	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-75	2710		GK	TRCN0000037634, TRCN0000037635	-0.654324825920328	none			GK_1_111101	Context-specific genetic dependencies (75)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HUTU80_SMALL_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-76	2710		GK	TRCN0000037634, TRCN0000037635	0.339057313041981	none			GK_1_111101	Context-specific genetic dependencies (76)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	IGR39_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-77	2710		GK	TRCN0000037634, TRCN0000037635	-0.220907937957688	none			GK_1_111101	Context-specific genetic dependencies (77)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	IGROV1_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-78	2710		GK	TRCN0000037634, TRCN0000037635	-0.148239513699573	none			GK_1_111101	Context-specific genetic dependencies (78)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	IOMMLEE_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-79	2710		GK	TRCN0000037634, TRCN0000037635	-0.233252151742528	none			GK_1_111101	Context-specific genetic dependencies (79)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	JHESOAD1_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-8	2710		GK	TRCN0000037634, TRCN0000037635	-0.719892900113306	none			GK_1_111101	Context-specific genetic dependencies (8)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A549_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-80	2710		GK	TRCN0000037634, TRCN0000037635	0.583549091544629	none			GK_1_111101	Context-specific genetic dependencies (80)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	JHOC5_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-81	2710		GK	TRCN0000037634, TRCN0000037635	-0.152859241283401	none			GK_1_111101	Context-specific genetic dependencies (81)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	JHOM1_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-82	2710		GK	TRCN0000037634, TRCN0000037635	-0.0848615280631706	none			GK_1_111101	Context-specific genetic dependencies (82)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-83	2710		GK	TRCN0000037634, TRCN0000037635	1.54688431963965	Increased shRNA abundance (Z-score > 2)			GK_1_111101	Context-specific genetic dependencies (83)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-84	2710		GK	TRCN0000037634, TRCN0000037635	-1.11936550307678	Decreased shRNA abundance (Z-score < -2)			GK_1_111101	Context-specific genetic dependencies (84)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KALS1_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-85	2710		GK	TRCN0000037634, TRCN0000037635	1.25191830159374	Increased shRNA abundance (Z-score > 2)			GK_1_111101	Context-specific genetic dependencies (85)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-86	2710		GK	TRCN0000037634, TRCN0000037635	-0.0320994211080847	none			GK_1_111101	Context-specific genetic dependencies (86)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KM12_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-87	2710		GK	TRCN0000037634, TRCN0000037635	0.946036875568621	none			GK_1_111101	Context-specific genetic dependencies (87)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-88	2710		GK	TRCN0000037634, TRCN0000037635	-0.168125120069858	none			GK_1_111101	Context-specific genetic dependencies (88)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KNS60_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-89	2710		GK	TRCN0000037634, TRCN0000037635	-0.898869850847548	none			GK_1_111101	Context-specific genetic dependencies (89)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KNS81_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-9	2710		GK	TRCN0000037634, TRCN0000037635	-0.139443177408807	none			GK_1_111101	Context-specific genetic dependencies (9)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A673_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-90	2710		GK	TRCN0000037634, TRCN0000037635	-0.288208762058984	none			GK_1_111101	Context-specific genetic dependencies (90)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KP1NL_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-91	2710		GK	TRCN0000037634, TRCN0000037635	-0.562761049907474	none			GK_1_111101	Context-specific genetic dependencies (91)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KP2_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-92	2710		GK	TRCN0000037634, TRCN0000037635	-0.122542432824186	none			GK_1_111101	Context-specific genetic dependencies (92)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KP4_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-93	2710		GK	TRCN0000037634, TRCN0000037635	0.0977159010676889	none			GK_1_111101	Context-specific genetic dependencies (93)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KURAMOCHI_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-94	2710		GK	TRCN0000037634, TRCN0000037635	-0.232125968733529	none			GK_1_111101	Context-specific genetic dependencies (94)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KYSE150_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-95	2710		GK	TRCN0000037634, TRCN0000037635	-0.306301208990222	none			GK_1_111101	Context-specific genetic dependencies (95)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KYSE30_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-96	2710		GK	TRCN0000037634, TRCN0000037635	0.388348273594299	none			GK_1_111101	Context-specific genetic dependencies (96)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KYSE450_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-97	2710		GK	TRCN0000037634, TRCN0000037635	-0.0476693509890021	none			GK_1_111101	Context-specific genetic dependencies (97)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KYSE510_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-98	2710		GK	TRCN0000037634, TRCN0000037635	0.0466128629445139	none			GK_1_111101	Context-specific genetic dependencies (98)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	L33_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-99	2710		GK	TRCN0000037634, TRCN0000037635	0.719782841710009	none			GK_1_111101	Context-specific genetic dependencies (99)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
	2710	2710	GK		0.060000000000000005	none
GR00371-A-1	2710	2710	GK		0.0569942889606	none			Dharmacon	Nanog expression in absence of bFGF and TGFbeta	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-2	2710	GK	2710		-0.119604410312	none			Dharmacon	Nanog expression in presence of TGFbeta inhibitor	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-3	2710	2710	GK		0.124866524849	none			Dharmacon	Nanog expression in presence of MEK inhibitor	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-4	2710	2710	GK		-0.12216472897	none			Dharmacon	Nanog expression in presence of PI3K inhibitor	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-5	2710	2710	GK		-0.806858438313	none			Dharmacon	Nanog expression in presence of retinoic acid	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00376-A-1	2710	2710	GK		0.192577688	none				Mitigators of SS1P-induced immunotoxicity	Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity	Pasetto et al.	2015	25713356	Cell line	KB cells	Viability	Luminescence	Ambion Silencer Select Version 4	Genome-wide	siRNA	RSA P-value	<0.001	SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID
GR00376-A-2	2710	2710	GK		0.032942185	none				Sensitizers of SS1P-induced immunotoxicity	Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity	Pasetto et al.	2015	25713356	Cell line	KB cells	Viability	Luminescence	Ambion Silencer Select Version 4	Genome-wide	siRNA	RSA P-value	<0.001	SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID
GR00378-A	2710		GK		-1.780745373	none				Poliovirus vaccine production	Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game	van der Sanden et al.	2015	26581994	Cell line	HEp-2C	Infection with Attenuated Poliovirus	ELISA	Dharmacon	Genome-wide	siRNA	Z-score	>	For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol
	2710	NM_000167	GK		74.918	none
GR00386-A-1	2710	2710	GK		83.3341504895276	none				NOD2 stimulation by MDP	A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion.	Warner et al.	2014	25170077	Cell line	HEK293 stably expressing NOD2	Viability	Luminescence	Dharmacon	Genome-wide	siRNA	Percentage growth	Decreased: <70, increased: >120	Reagent IDs not provided
GR00386-A-2	2710	2710	GK		61.2	Decreased IL-8 secretion				MDP-induced IL-8 secretion	A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion.	Warner et al.	2014	25170077	Cell line	HEK293 stably expressing NOD2	IL-8 secretion	ELISA	Dharmacon	Genome-wide	siRNA	Percent inhibition of IL-8 secretion	Increased: <-300, Decreased: >60	Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided