RNAi

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 3516
• Symbol: RBPJ
• Description: recombination signal binding protein for immunoglobulin kappa J region

DataSource: http://genomernai.dkfz.de/v16/genedetails/3516

Export (tab separated) Export to Excel

Stable_ID	Entrez_ID	Gene_ID	Gene_Symbol	Reagent_ID	Score	Phenotype	Conditions	Follow_Up	Comment	Screen_Title	Publication_Title	Authors	Publication_Year	Pubmed_ID	Biosource	Biomodel	Assay	Method	Library	Scope	Reagent_Type	Score_Type	Cutoff	Notes
GR00053-A	3516	NM_005349	RBPSUH	np	sp	none		no		Genome stability	A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.	Paulsen et al.	2009	19647519	Cell line	HeLa	gamma-H2AX phosphorylation and DNA content	Fluorescence	siARRAY human genome siRNA library	Genome-wide	siRNA	p-value	Complex criteria	Confidence groupings from 4 to 1 (highest level of confidence in group 4)
GR00054-A	3516	NM_005349	RBPSUH	np	0.968	none		no		Combinatorial effect with paclitaxel	Synthetic lethal screen identification of chemosensitizer loci in cancer cells.	Whitehurst et al.	2007	17429401	Cell line	NCI-H1155	Viability (synthetic lethal)	ATP level	# G-005000-01	Genome-wide	siRNA	Paclitaxel/control ratio	Complex criteria	Additional information about 87 high-confidence hits
GR00056-A	3516	NM_005349	RBPSUH	np	0.889	none		no		Melanogenesis	Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.	Ganesan et al.	2008	19057677	Cell line	MNT-1	Melanin protein expression and viability	Absorbance and luminescence	rp	Genome-wide	siRNA	Normalized absorbance ratio	> 2 standard deviations below mean	Additional information about a secondary screen (retest to determine false-positive rate)
GR00057-A-1	3516	NM_005349	RBPSUH	M-007772-00	0.11	none		no		Wnt/beta-catenin pathway regulation (1)	A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer.	Tang et al.	2008	18621708	Cell line	HeLa	Wnt pathway reporter	Luminescence	Human siArray siRNA library	Genome-wide	siRNA	Z-score	> 4	Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00057-A-2	3516	NM_005349	RBPSUH	M-007772-00	sp	none		no		Wnt/beta-catenin pathway regulation (2)	A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer.	Tang et al.	2008	18621708	Cell line	HeLa	Wnt pathway reporter	Luminescence	Human siArray siRNA library	Genome-wide	siRNA	Complex, SP	Complex criteria	Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00095-A	3516	L07872	RBPSUH	np	np	none				p53 pathway components	A large-scale RNAi screen in human cells identifies new components of the p53 pathway	Berns et al.	2004	15042092	Cell line	BJ-TERT-tsLT fibroblasts	Proliferation	Colony-forming cell assay	Nki library	Genome-wide	shRNA	np	np
GR00095-A	3516	L07875	RBPSUH	np	np	none				p53 pathway components	A large-scale RNAi screen in human cells identifies new components of the p53 pathway	Berns et al.	2004	15042092	Cell line	BJ-TERT-tsLT fibroblasts	Proliferation	Colony-forming cell assay	Nki library	Genome-wide	shRNA	np	np
GR00098-A-1	3516	ENSG00000168214	RBPSUH	ENSG00000168214	sp	none		no		Cell division (1)	Genome-scale RNAi profiling of cell division in human tissue culture cells.	Kittler et al.	2007	17994010	Cell line	HeLa	Cell number and DNA content	Laser scanning cytometry	rp	Genome-wide	esiRNA	Complex, sp	Complex criteria
GR00123-A	3516	L07875	RBPSUH	109853, 109851, 109852	np	none				Combinatorial effect with nutlin-3	An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors	Brummelkamp et al.	2006	16474381	Cell line	MCF-7	Viability	Fluoresence	Nki library	Genome-wide	shRNA	log2 ratio	np
GR00123-A	3516	L07872	RBPSUH	109841, 109843, 109842	np	none				Combinatorial effect with nutlin-3	An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors	Brummelkamp et al.	2006	16474381	Cell line	MCF-7	Viability	Fluoresence	Nki library	Genome-wide	shRNA	log2 ratio	np
GR00149-A-1	3516	3516	RBPSUH	145252	-46.24	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	3516	3516	RBPSUH	145252	17.34	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	3516	3516	RBPSUH	145253	1.1	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	3516	3516	RBPSUH	145253	22.3	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	3516	3516	RBPSUH	145254	-12	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	3516	3516	RBPSUH	145254	4.4	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	3516	3516	RBPSUH	290347	-35.16	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	3516	3516	RBPSUH	290347	-40.04	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00151-A-1	3516	ENSG00000168214	RBPSUH	np	0.322	none		no		Homologous recombination DNA double-strand break repair (HR-DSBR) (1)	A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.	SÅ‚abicki et al.	2010	20613862	Cell line	HeLa	(HR-DSBR) DR-GFP reporter	Flow cytometry	Custom-made	Genome-wide	esiRNA	Z-score	< -2 OR > 2
GR00180-A-1	3516	3516	RBPJ	PL-50014	0.918	none		no		Hepatitis C virus replication (1)	A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.	Tai et al.	2009	19286138	Cell line	Huh7/Rep-Feo	HCV replicon RNA copy number	Luminescence	siARRAY Human Genome siRNA Library	Genome-wide	siRNA	q-value	Complex criteria
GR00184-A-1	3516	NM_005349	RBPJ	M-007772-00	-1.69845609792504	none		no		Self-renewal and pluripotency in human embryonic stem cells (1)	A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.	Chia et al.	2010	20953172	Cell line	hESC H1	POU5F1 protein expression	Fluorescence	SMARTpool siRNA library	Genome-wide	siRNA	Z-score	< -2
GR00196-A-1	3516	ENSG00000168214		np	sp	none		no		TP53 interactions (1)	A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly.	Krastev et al.	2011	21642980	Cell line	HCT116 ( wildtype and TP53 knockout)	TP53 protein expression and viability	Fluorescence	rp	Genome-wide	esiRNA	Complex, sp	Complex criteria
GR00197-A-1	3516	3516	RBPJ	M-007772-00	0.188257269	none		no		Human papillomavirus oncogene expression regulation (1)	Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression.	Smith et al.	2010	20133580	Cell line	C33A/BE2/18LCR c4	HPV18 LCR reporter activity	Luminescence	Human siGENOME SMARTpool library	Genome-wide	siRNA	Z-score	>	Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5
GR00236-A-1	3516	3516	RBPJ	M-007772-00	1.301668599614	none		no		Homologous recombination DNA double-strand break repair (HR-DSBR) (1)	A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.	Adamson et al.	2012	22344029	Cell line	DR-U2OS	(HR-DSBR) DR-GFP reporter and DNA content	Fluorescence	Human siGENOME siRNA (G-005000-05)	Genome-wide	siRNA	Relative HR ratio	< ~0.4 OR > 1.88	Cutoff values correspond 2 standard deviations from the screen-wide mean
GR00240-S-1	3516	NM_005349	RBPSUH	M-007772-00	0.22	none		yes		TRAIL-induced apoptosis (1)	A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis.	Kranz and Boutros	2014	24442637	Cell line	U251MG	Viability	Luminescence	SMART-pool siRNA	Genome-wide	siRNA	Z-score	> 4	Author-submitted data
GR00240-S-2	3516	NM_005349	RBPSUH	M-007772-00	-0.15	none		no	Z-score 0.0825	TRAIL-induced apoptosis (2)	A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis.	Kranz and Boutros	2014	24442637	Cell line	U251MG	Viability (synthetic lethal)	Luminescence	SMART-pool siRNA	Genome-wide	siRNA	Differential score	> 3.6 AND viability Z-score < 4	Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen.
GR00242-A-1	3516	NM_005349	RBPSUH	np	np	none		no		Selective autophagy regulation (1)	Image-based genome-wide siRNA screen identifies selective autophagy factors.	Orvedahl et al.	2011	22020285	Cell line	HeLa/GFP-LC3	Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression	Fluorescence	siGenome	Genome-wide	siRNA	Z-score	Complex criteria
GR00247-A-1	3516		RBPJ	np	sp	none			rank: 8321	Regulation of FOXO1 nuclear localization (1)	Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain.	Senapedis et al.	2011	21460183	Cell line	U2OS	EGFP-FOXO1a protein expression and DNA content	Fluorescence	Human Genome library	Genome-wide	siRNA	Complex, sp	Complex criteria
GR00249-S	3516	3516	RBPSUH	J-007772-05	-0.38205	none		no	number of cells compared to control (%): 88.78	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	3516	3516	RBPSUH	M-007772-00	-0.34199	none		no	number of cells compared to control (%): 68.13	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	3516	3516	RBPJ	s223924	0.06133	none		no	number of cells compared to control (%): 75.18	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	3516	3516	RBPJ	s7251	-0.5047	none		no	number of cells compared to control (%): 77.58	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	3516	3516	RBPJ	s7253	0.50611	none		no	number of cells compared to control (%): 99.76	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00253-A	3516	NM_005349	RBPSUH	np	0.334	none				hepcidin regulation	Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.	Mleczko-Sanecka et al.	2014	24385536	Cell line	Huh7	hepcidin::fluc mRNA expression	Luminescence	siGenome siARRAY SMARTpool	Genome-wide	siRNA	Z-score	>	Cutoff <
GR00255-A-1	3516	3516	RBPJ	TRCN0000016203, TRCN0000016204, TRCN0000016205, TRCN0000016206, TRCN0000016207	0.491386237	none				Negative genetic interactions (1)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -1.0	HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-2	3516	3516	RBPJ	TRCN0000016203, TRCN0000016204, TRCN0000016205, TRCN0000016206, TRCN0000016207	-0.126725733	none				Negative genetic interactions (2)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -1.0	HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-3	3516	3516	RBPJ	TRCN0000016203, TRCN0000016204, TRCN0000016205, TRCN0000016206, TRCN0000016207	-0.00642589	none				Negative genetic interactions (3)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -1.2	HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-4	3516	3516	RBPJ	TRCN0000016203, TRCN0000016204, TRCN0000016205, TRCN0000016206, TRCN0000016207	0.257182678	none				Negative genetic interactions (4)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -1.2	HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-5	3516	3516	RBPJ	TRCN0000016203, TRCN0000016204, TRCN0000016205, TRCN0000016206, TRCN0000016207	0.207875131	none				Negative genetic interactions (5)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -0.8	HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00293-A	3516		RBPSUH	np	0.843	none				Combinatorial effect with paclitaxel	Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death	Sinnott et al.	2014	24860162	Cell line	HCC366	Viability	Luminescence	Thermo-Fisher	Genome-wide	siRNA	Z-score	< -2.5	Final hits according to the author are indicated in the comment.
GR00300-A	3516		RBPSUH	TRCN0000016206, TRCN0000016207, TRCN0000016204, TRCN0000016205, TRCN0000016203	0	none				Combinatorial effect with RAF inhibitor PLX4720	A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.	Whittaker et al.	2013	23288408	Cell line	A375	shRNA abundance	Sequencing	TRC	Genome-wide	shRNA	Number of shRNAs ranked Top1000	> 2	The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors.
GR00303-A	3516	NM_005349	RBPSUH	np	-0.15	none				Clear cell renal cell carcinoma (ccRCC) survival regulation	Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target	Gerlinger et al.	2012	22362593	Cell line	VHL-deficient RCC4	Proliferation and Viability	Fluorescence	np	Genome-wide	siRNA	Z-score	<	In the phenotype data duplicates were in the original document, which have been removed.
GR00310-A-1	3516	3516	RBPSUH	np	0.15	none				Sindbis virus (SINV) infection (1)	Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry	Ooi et al.	2013	24367265	Cell line	U2OS	Sindbis virus (SINV) reporter	Luminescence	Ambion Silencer V3	Genome-wide	siRNA	Z-score	< -3 OR > 2
	3516	3516	RBPJ	np	3.2	none			98,1% viability
GR00313-A	3516	NM_005349	RBPSUH	np	0.47	none				TNF-alpha pathway regulation	A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling.	Nickles et al.	2012	22733992	Cell line	HEK293T	NFkappaB pathway reporter	Luminescence	Qiagen	Genome-wide	siRNA	Z-score	<	Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%.
GR00318-A	3516	3516	RBPSUH	np	0.92	none			siRNA set: druggable genome	Huntingtin toxicity	A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease	Miller et al.	2012	23209424	Cell line	HEK293T	Caspase 3/7 activity	Fluorescence	Dharmacon	Selected genes	siRNA	Sum of normalized caspase 3/7 activity mean and standard error	< 0.683	HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP).
GR00327-A	3516	3516	LPHN3	CLL-H-015837	-1.073834333250757	none				Tumor formation	An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation	Wolf et al.	2013	24292671	Cell line	SUM-149	shRNA abundance	Next-generation sequencing	Decipher library module 1	Selected genes	shRNA	Z-score	> 2.24	Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A	3516	3516	LPHN3	CLL-H-015839	-0.784377634338207	none				Tumor formation	An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation	Wolf et al.	2013	24292671	Cell line	SUM-149	shRNA abundance	Next-generation sequencing	Decipher library module 1	Selected genes	shRNA	Z-score	> 2.24	Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A	3516	3516	LPHN3	CLL-H-015838	-0.7120304090948344	none				Tumor formation	An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation	Wolf et al.	2013	24292671	Cell line	SUM-149	shRNA abundance	Next-generation sequencing	Decipher library module 1	Selected genes	shRNA	Z-score	> 2.24	Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A	3516	3516	LPHN3	CLL-H-015836	0.15993005279367228	none				Tumor formation	An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation	Wolf et al.	2013	24292671	Cell line	SUM-149	shRNA abundance	Next-generation sequencing	Decipher library module 1	Selected genes	shRNA	Z-score	> 2.24	Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A	3516	3516	LPHN3	CLL-H-015835	-1.6105799410263046	none				Tumor formation	An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation	Wolf et al.	2013	24292671	Cell line	SUM-149	shRNA abundance	Next-generation sequencing	Decipher library module 1	Selected genes	shRNA	Z-score	> 2.24	Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00343-S	3516	3516	RBPSUH	TRCN0000016204	0.8375000000000004	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	3516	3516	RBPSUH	TRCN0000016203	-1.7249999999999996	shRNA abundance <= 50%				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	3516	3516	RBPSUH	TRCN0000016206	0.7050000000000018	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	3516	3516	RBPSUH	TRCN0000016205	2.5950000000000006	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	3516	3516	RBPSUH	TRCN0000016207	-0.037499999999999645	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00363-A	3516	3516	RBPJ	SI00700497, SI00700504, 243260, esi11923	sp	Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis			strong	Endocytosis regulation	Systems survey of endocytosis by multiparametric image analysis.	Collinet et al.	2010	20190736	Cell line	HeLa	Transferrin (TF) and epidermal growth factor (EGF) subcellular localisation, DNA content	Fluorescence	Ambion, Qiagen and esiRNA library (Kittler et al.)	Genome-wide	siRNA	Complex, sp	Complex criteria	Two hit categories: "strong" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn > 0.95) and "weak but specific" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn < 0.95 but Phenoscore > 0.95). Additional information about secondary screens with kinase and phospatase libraries.
GR00366-A-1	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.300317724423395	none			RBPJ_1_1011	Context-specific genetic dependencies (1)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	22RV1_PROSTATE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-10	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-1.08775244017333	none			RBPJ_1_1011	Context-specific genetic dependencies (10)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	ACHN_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-100	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.69693915642371	none			RBPJ_1_1011	Context-specific genetic dependencies (100)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-101	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.476515358694495	none			RBPJ_1_1011	Context-specific genetic dependencies (101)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LK2_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-102	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.10781949327901	none			RBPJ_1_1011	Context-specific genetic dependencies (102)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN215_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-103	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.145125892825522	none			RBPJ_1_1011	Context-specific genetic dependencies (103)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN229_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-104	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.18835237025972	none			RBPJ_1_1011	Context-specific genetic dependencies (104)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN235_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-105	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.493932515605684	none			RBPJ_1_1011	Context-specific genetic dependencies (105)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN319_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-106	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.867077662772013	none			RBPJ_1_1011	Context-specific genetic dependencies (106)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN340_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-107	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.42242771927786	none			RBPJ_1_1011	Context-specific genetic dependencies (107)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN382_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-108	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.436591422695668	none			RBPJ_1_1011	Context-specific genetic dependencies (108)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN428_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-109	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.254116388381108	none			RBPJ_1_1011	Context-specific genetic dependencies (109)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN443_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-11	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.786875948144589	none			RBPJ_1_1011	Context-specific genetic dependencies (11)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	AGS_STOMACH	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-110	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.840895663642301	none			RBPJ_1_1011	Context-specific genetic dependencies (110)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN464_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-111	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.524961782679833	none			RBPJ_1_1011	Context-specific genetic dependencies (111)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LNZ308_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-112	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.767902856889822	none			RBPJ_1_1011	Context-specific genetic dependencies (112)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LOVO_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-113	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.978142754705827	none			RBPJ_1_1011	Context-specific genetic dependencies (113)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LS411N_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-114	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.377016260230358	none			RBPJ_1_1011	Context-specific genetic dependencies (114)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LS513_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-115	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.361931475915014	none			RBPJ_1_1011	Context-specific genetic dependencies (115)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MCF7_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-116	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.34689009147908	none			RBPJ_1_1011	Context-specific genetic dependencies (116)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MDAMB453_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-117	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.400569667352648	none			RBPJ_1_1011	Context-specific genetic dependencies (117)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MIAPACA2_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-118	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.520538253351071	none			RBPJ_1_1011	Context-specific genetic dependencies (118)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MKN7_STOMACH	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-119	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.879040424948577	none			RBPJ_1_1011	Context-specific genetic dependencies (119)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-12	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.391672298098584	none			RBPJ_1_1011	Context-specific genetic dependencies (12)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	AM38_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-120	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.787300742120261	none			RBPJ_1_1011	Context-specific genetic dependencies (120)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-121	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.0814370046469578	none			RBPJ_1_1011	Context-specific genetic dependencies (121)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-122	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.590133758758827	none			RBPJ_1_1011	Context-specific genetic dependencies (122)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-123	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.43783025197543	Increased shRNA abundance (Z-score > 2)			RBPJ_1_1011	Context-specific genetic dependencies (123)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-124	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.64785759367324	none			RBPJ_1_1011	Context-specific genetic dependencies (124)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-125	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.0605883304443374	none			RBPJ_1_1011	Context-specific genetic dependencies (125)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-126	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.736543021445487	none			RBPJ_1_1011	Context-specific genetic dependencies (126)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1299_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-127	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.618060177430252	none			RBPJ_1_1011	Context-specific genetic dependencies (127)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1437_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-128	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.284126733765107	none			RBPJ_1_1011	Context-specific genetic dependencies (128)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1650_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-129	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-1.02990490789428	none			RBPJ_1_1011	Context-specific genetic dependencies (129)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1792_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-13	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.739545349144186	none			RBPJ_1_1011	Context-specific genetic dependencies (13)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-130	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.475184790571383	none			RBPJ_1_1011	Context-specific genetic dependencies (130)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH196_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-131	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.0159081264992849	none			RBPJ_1_1011	Context-specific genetic dependencies (131)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1975_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-132	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.88432854802465	none			RBPJ_1_1011	Context-specific genetic dependencies (132)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH2052_PLEURA	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-133	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.776888187684872	none			RBPJ_1_1011	Context-specific genetic dependencies (133)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH2122_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-134	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.208520670169983	none			RBPJ_1_1011	Context-specific genetic dependencies (134)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH2171_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-135	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.0402687248279313	none			RBPJ_1_1011	Context-specific genetic dependencies (135)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH23_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-136	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.0144643333955548	none			RBPJ_1_1011	Context-specific genetic dependencies (136)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH2452_PLEURA	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-137	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.860254489201394	none			RBPJ_1_1011	Context-specific genetic dependencies (137)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH441_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-138	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.831514776618251	none			RBPJ_1_1011	Context-specific genetic dependencies (138)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH508_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-139	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.71182797939372	Increased shRNA abundance (Z-score > 2)			RBPJ_1_1011	Context-specific genetic dependencies (139)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH660_PROSTATE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-14	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.0693651925187946	none			RBPJ_1_1011	Context-specific genetic dependencies (14)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	ASPC1_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-140	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.18924506085001	none			RBPJ_1_1011	Context-specific genetic dependencies (140)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH661_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-141	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.66493315662802	none			RBPJ_1_1011	Context-specific genetic dependencies (141)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH716_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-142	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.351297394018871	none			RBPJ_1_1011	Context-specific genetic dependencies (142)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH838_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-143	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.879147698492261	none			RBPJ_1_1011	Context-specific genetic dependencies (143)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIN87_STOMACH	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-144	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.144171720527499	none			RBPJ_1_1011	Context-specific genetic dependencies (144)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NIHOVCAR3_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-145	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.0626316549786576	none			RBPJ_1_1011	Context-specific genetic dependencies (145)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-146	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.428716260474286	none			RBPJ_1_1011	Context-specific genetic dependencies (146)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OAW42_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-147	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.193596369684283	none			RBPJ_1_1011	Context-specific genetic dependencies (147)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-148	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.0679866342077163	none			RBPJ_1_1011	Context-specific genetic dependencies (148)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-149	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.705546364732047	none			RBPJ_1_1011	Context-specific genetic dependencies (149)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-15	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.183631642288374	none			RBPJ_1_1011	Context-specific genetic dependencies (15)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	BT20_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-150	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.407969913951828	none			RBPJ_1_1011	Context-specific genetic dependencies (150)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OE33_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-151	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.738310944204654	none			RBPJ_1_1011	Context-specific genetic dependencies (151)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OELE_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-152	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.168476543116894	none			RBPJ_1_1011	Context-specific genetic dependencies (152)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-153	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.727547019313844	none			RBPJ_1_1011	Context-specific genetic dependencies (153)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OV7_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-154	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.00498240853898238	none			RBPJ_1_1011	Context-specific genetic dependencies (154)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OV90_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-155	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.0379445576114214	none			RBPJ_1_1011	Context-specific genetic dependencies (155)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OVCAR4_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-156	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.639783656182059	none			RBPJ_1_1011	Context-specific genetic dependencies (156)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OVCAR8_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-157	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.242737835648387	none			RBPJ_1_1011	Context-specific genetic dependencies (157)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OVISE_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-158	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.886090797078333	none			RBPJ_1_1011	Context-specific genetic dependencies (158)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PANC0327_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-159	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.311351704441341	none			RBPJ_1_1011	Context-specific genetic dependencies (159)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PANC0813_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-16	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.10890470957582	none			RBPJ_1_1011	Context-specific genetic dependencies (16)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	BT474_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-160	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.174690313312409	none			RBPJ_1_1011	Context-specific genetic dependencies (160)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PANC1005_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-161	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.824167484301584	none			RBPJ_1_1011	Context-specific genetic dependencies (161)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-162	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.413136013569988	none			RBPJ_1_1011	Context-specific genetic dependencies (162)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PSN1_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-163	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.82403252475838	none			RBPJ_1_1011	Context-specific genetic dependencies (163)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	QGP1_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-164	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.145131783294274	none			RBPJ_1_1011	Context-specific genetic dependencies (164)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-165	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.734731508475829	none			RBPJ_1_1011	Context-specific genetic dependencies (165)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RKN_SOFT_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-166	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.0195908506770558	none			RBPJ_1_1011	Context-specific genetic dependencies (166)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RKO_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-167	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.0857558807419211	none			RBPJ_1_1011	Context-specific genetic dependencies (167)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RMGI_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-168	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.254751710137529	none			RBPJ_1_1011	Context-specific genetic dependencies (168)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RMUGS_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-169	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.384547598212649	none			RBPJ_1_1011	Context-specific genetic dependencies (169)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-17	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.300119649240952	none			RBPJ_1_1011	Context-specific genetic dependencies (17)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	BXPC3_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-170	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.461261487102128	none			RBPJ_1_1011	Context-specific genetic dependencies (170)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RT112_URINARY_TRACT	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-171	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.820673729593386	none			RBPJ_1_1011	Context-specific genetic dependencies (171)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-172	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.429990999563435	none			RBPJ_1_1011	Context-specific genetic dependencies (172)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SF126_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-173	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.16901109188392	none			RBPJ_1_1011	Context-specific genetic dependencies (173)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SF172_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-174	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.463335112870839	none			RBPJ_1_1011	Context-specific genetic dependencies (174)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SF295_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-175	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.328617817765219	none			RBPJ_1_1011	Context-specific genetic dependencies (175)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SF767_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-176	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-1.05472748997578	none			RBPJ_1_1011	Context-specific genetic dependencies (176)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SJSA1_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-177	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.44036804306345	Increased shRNA abundance (Z-score > 2)			RBPJ_1_1011	Context-specific genetic dependencies (177)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKCO1_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-178	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.348608642532181	none			RBPJ_1_1011	Context-specific genetic dependencies (178)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKMEL5_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-179	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.171649742598607	none			RBPJ_1_1011	Context-specific genetic dependencies (179)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-18	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.178259600286887	none			RBPJ_1_1011	Context-specific genetic dependencies (18)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	C2BBE1_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-180	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.36668380192602	Increased shRNA abundance (Z-score > 2)			RBPJ_1_1011	Context-specific genetic dependencies (180)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-181	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.0867382289783942	none			RBPJ_1_1011	Context-specific genetic dependencies (181)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKOV3_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-182	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.245295665991061	none			RBPJ_1_1011	Context-specific genetic dependencies (182)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKRC20_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-183	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.55778038759955	none			RBPJ_1_1011	Context-specific genetic dependencies (183)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR20_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-184	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.215553431230295	none			RBPJ_1_1011	Context-specific genetic dependencies (184)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR21_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-185	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.365767908894464	none			RBPJ_1_1011	Context-specific genetic dependencies (185)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR23_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-186	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.195067018028558	none			RBPJ_1_1011	Context-specific genetic dependencies (186)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR24_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-187	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.0985329241904244	none			RBPJ_1_1011	Context-specific genetic dependencies (187)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR25_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-188	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.633582354290638	none			RBPJ_1_1011	Context-specific genetic dependencies (188)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR26_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-189	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.36772936182472	Increased shRNA abundance (Z-score > 2)			RBPJ_1_1011	Context-specific genetic dependencies (189)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SNU1105_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-19	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.73330235781282	none			RBPJ_1_1011	Context-specific genetic dependencies (19)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	C32_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-190	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.39850003018517	none			RBPJ_1_1011	Context-specific genetic dependencies (190)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SNU840_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-191	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.14542534095745	none			RBPJ_1_1011	Context-specific genetic dependencies (191)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SNUC1_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-192	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.619214316457571	none			RBPJ_1_1011	Context-specific genetic dependencies (192)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SNUC2A_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-193	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.65277972877981	none			RBPJ_1_1011	Context-specific genetic dependencies (193)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SU8686_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-194	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.40093999732738	none			RBPJ_1_1011	Context-specific genetic dependencies (194)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SW1417_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-195	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.576687371103743	none			RBPJ_1_1011	Context-specific genetic dependencies (195)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SW1783_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-196	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.374199420492944	none			RBPJ_1_1011	Context-specific genetic dependencies (196)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SW480_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-197	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.295164946923899	none			RBPJ_1_1011	Context-specific genetic dependencies (197)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SW48_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-198	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.487327921284562	none			RBPJ_1_1011	Context-specific genetic dependencies (198)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	T98G_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-199	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.205244773618323	none			RBPJ_1_1011	Context-specific genetic dependencies (199)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TC71_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-2	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.0370008742933794	none			RBPJ_1_1011	Context-specific genetic dependencies (2)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-20	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.305539703415569	none			RBPJ_1_1011	Context-specific genetic dependencies (20)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CADOES1_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-200	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.320121880801385	none			RBPJ_1_1011	Context-specific genetic dependencies (200)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TCCSUP_URINARY_TRACT	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-201	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.485161233440001	none			RBPJ_1_1011	Context-specific genetic dependencies (201)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TE10_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-202	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.863772712071308	none			RBPJ_1_1011	Context-specific genetic dependencies (202)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TE15_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-203	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.231815957694482	none			RBPJ_1_1011	Context-specific genetic dependencies (203)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TE9_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-204	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.260511486585479	none			RBPJ_1_1011	Context-specific genetic dependencies (204)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-205	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.430062353272938	none			RBPJ_1_1011	Context-specific genetic dependencies (205)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TOV112D_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-206	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.116817901699149	none			RBPJ_1_1011	Context-specific genetic dependencies (206)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TOV21G_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-207	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.842510131992577	none			RBPJ_1_1011	Context-specific genetic dependencies (207)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TT_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-208	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.594066773522066	none			RBPJ_1_1011	Context-specific genetic dependencies (208)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TYKNU_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-209	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.0701718628026472	none			RBPJ_1_1011	Context-specific genetic dependencies (209)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	U178_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-21	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.301355914709242	none			RBPJ_1_1011	Context-specific genetic dependencies (21)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAL120_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-210	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.0219406906177967	none			RBPJ_1_1011	Context-specific genetic dependencies (210)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	U251MG_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-211	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.850772986117665	none			RBPJ_1_1011	Context-specific genetic dependencies (211)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	U343_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-212	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-1.08406095392489	none			RBPJ_1_1011	Context-specific genetic dependencies (212)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	U87MG_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-213	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.929541042505846	none			RBPJ_1_1011	Context-specific genetic dependencies (213)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	UOK101_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-214	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.320032968566783	none			RBPJ_1_1011	Context-specific genetic dependencies (214)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	VCAP_PROSTATE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-215	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.446864231758946	none			RBPJ_1_1011	Context-specific genetic dependencies (215)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	YKG1_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-216	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.312114843711056	none			RBPJ_1_1011	Context-specific genetic dependencies (216)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	ZR7530_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-22	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.138158073227813	none			RBPJ_1_1011	Context-specific genetic dependencies (22)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAL51_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-23	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-1.10083040350661	none			RBPJ_1_1011	Context-specific genetic dependencies (23)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CALU1_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-24	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.120335451276022	none			RBPJ_1_1011	Context-specific genetic dependencies (24)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAOV3_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-25	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.66956193058636	none			RBPJ_1_1011	Context-specific genetic dependencies (25)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAOV4_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-26	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.140330370534353	none			RBPJ_1_1011	Context-specific genetic dependencies (26)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAS1_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-27	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.600948123884054	none			RBPJ_1_1011	Context-specific genetic dependencies (27)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CFPAC1_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-28	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.124030713342079	none			RBPJ_1_1011	Context-specific genetic dependencies (28)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CH157MN_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-29	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.0596808466576233	none			RBPJ_1_1011	Context-specific genetic dependencies (29)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COLO205_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-3	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.533309513078461	none			RBPJ_1_1011	Context-specific genetic dependencies (3)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	786O_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-30	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.347113840504394	none			RBPJ_1_1011	Context-specific genetic dependencies (30)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COLO704_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-31	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.263350646815835	none			RBPJ_1_1011	Context-specific genetic dependencies (31)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COLO741_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-32	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.190606054429344	none			RBPJ_1_1011	Context-specific genetic dependencies (32)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COLO783_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-33	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-1.03024888912474	none			RBPJ_1_1011	Context-specific genetic dependencies (33)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CORL23_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-34	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.153633038575822	none			RBPJ_1_1011	Context-specific genetic dependencies (34)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COV362_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-35	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.284244362704891	none			RBPJ_1_1011	Context-specific genetic dependencies (35)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COV434_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-36	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.181431396991086	none			RBPJ_1_1011	Context-specific genetic dependencies (36)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COV504_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-37	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.213810490158503	none			RBPJ_1_1011	Context-specific genetic dependencies (37)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COV644_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-38	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.239935264714883	none			RBPJ_1_1011	Context-specific genetic dependencies (38)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	DBTRG05MG_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-39	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.0452024287038898	none			RBPJ_1_1011	Context-specific genetic dependencies (39)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	DKMG_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-4	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.932913289226401	none			RBPJ_1_1011	Context-specific genetic dependencies (4)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A1207_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-40	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.160136759196358	none			RBPJ_1_1011	Context-specific genetic dependencies (40)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	DLD1_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-41	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	2.52522794612062	Increased shRNA abundance (Z-score > 2)			RBPJ_1_1011	Context-specific genetic dependencies (41)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EFE184_ENDOMETRIUM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-42	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.238706353402233	none			RBPJ_1_1011	Context-specific genetic dependencies (42)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EFM19_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-43	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.166134549594074	none			RBPJ_1_1011	Context-specific genetic dependencies (43)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EFO21_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-44	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.298100777410504	none			RBPJ_1_1011	Context-specific genetic dependencies (44)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EFO27_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-45	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.266814246418307	none			RBPJ_1_1011	Context-specific genetic dependencies (45)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EW8_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-46	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.7796988059196	Increased shRNA abundance (Z-score > 2)			RBPJ_1_1011	Context-specific genetic dependencies (46)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EWS502_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-47	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.70963596876749	Increased shRNA abundance (Z-score > 2)			RBPJ_1_1011	Context-specific genetic dependencies (47)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-48	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.199768649422738	none			RBPJ_1_1011	Context-specific genetic dependencies (48)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	GB1_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-49	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.22657016240072	none			RBPJ_1_1011	Context-specific genetic dependencies (49)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	GP2D_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-5	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-1.18320437364832	none			RBPJ_1_1011	Context-specific genetic dependencies (5)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A172_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-50	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.577167556214966	none			RBPJ_1_1011	Context-specific genetic dependencies (50)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC1187_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-51	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.338175656170851	none			RBPJ_1_1011	Context-specific genetic dependencies (51)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC1395_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-52	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.189836901886552	none			RBPJ_1_1011	Context-specific genetic dependencies (52)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC1954_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-53	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.436525736337267	none			RBPJ_1_1011	Context-specific genetic dependencies (53)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC2218_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-54	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.387048638067851	none			RBPJ_1_1011	Context-specific genetic dependencies (54)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC2814_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-55	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.127883055923564	none			RBPJ_1_1011	Context-specific genetic dependencies (55)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC364_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-56	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.308208911727825	none			RBPJ_1_1011	Context-specific genetic dependencies (56)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC44_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-57	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.708305830833392	none			RBPJ_1_1011	Context-specific genetic dependencies (57)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC70_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-58	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.387036303133291	none			RBPJ_1_1011	Context-specific genetic dependencies (58)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC827GR5_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-59	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.406601061468622	none			RBPJ_1_1011	Context-specific genetic dependencies (59)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC827_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-6	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.0568636549909096	none			RBPJ_1_1011	Context-specific genetic dependencies (6)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A204_SOFT_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-60	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.172080020245882	none			RBPJ_1_1011	Context-specific genetic dependencies (60)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCT116_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-61	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.293366013360232	none			RBPJ_1_1011	Context-specific genetic dependencies (61)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HEC1A_ENDOMETRIUM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-62	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.93856381736636	none			RBPJ_1_1011	Context-specific genetic dependencies (62)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HEYA8_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-63	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.643175259327108	none			RBPJ_1_1011	Context-specific genetic dependencies (63)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-64	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.203157616077646	none			RBPJ_1_1011	Context-specific genetic dependencies (64)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HLF_LIVER	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-65	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.823991061648946	none			RBPJ_1_1011	Context-specific genetic dependencies (65)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-66	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.104196656379047	none			RBPJ_1_1011	Context-specific genetic dependencies (66)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HPAC_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-67	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.378255206974179	none			RBPJ_1_1011	Context-specific genetic dependencies (67)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HPAFII_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-68	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.597080362167351	none			RBPJ_1_1011	Context-specific genetic dependencies (68)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HS683_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-69	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.528389839638003	none			RBPJ_1_1011	Context-specific genetic dependencies (69)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HS766T_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-7	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.352862224306815	none			RBPJ_1_1011	Context-specific genetic dependencies (7)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A2058_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-70	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.4883389021946	none			RBPJ_1_1011	Context-specific genetic dependencies (70)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HS944T_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-71	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-1.15990892902917	none			RBPJ_1_1011	Context-specific genetic dependencies (71)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HT1197_URINARY_TRACT	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-72	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.156845030817202	none			RBPJ_1_1011	Context-specific genetic dependencies (72)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HT29_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-73	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.641004217696311	none			RBPJ_1_1011	Context-specific genetic dependencies (73)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HT55_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-74	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.861147458541389	none			RBPJ_1_1011	Context-specific genetic dependencies (74)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HUG1N_STOMACH	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-75	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.762856533479198	none			RBPJ_1_1011	Context-specific genetic dependencies (75)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HUTU80_SMALL_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-76	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.575188401102915	none			RBPJ_1_1011	Context-specific genetic dependencies (76)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	IGR39_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-77	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.180659839624271	none			RBPJ_1_1011	Context-specific genetic dependencies (77)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	IGROV1_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-78	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.478475142259527	none			RBPJ_1_1011	Context-specific genetic dependencies (78)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	IOMMLEE_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-79	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.49646836079808	Increased shRNA abundance (Z-score > 2)			RBPJ_1_1011	Context-specific genetic dependencies (79)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	JHESOAD1_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-8	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.654051989337965	none			RBPJ_1_1011	Context-specific genetic dependencies (8)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A549_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-80	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.164029604631822	none			RBPJ_1_1011	Context-specific genetic dependencies (80)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	JHOC5_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-81	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.650431057498462	none			RBPJ_1_1011	Context-specific genetic dependencies (81)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	JHOM1_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-82	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.894909416733543	none			RBPJ_1_1011	Context-specific genetic dependencies (82)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-83	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.584059529983404	none			RBPJ_1_1011	Context-specific genetic dependencies (83)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-84	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.760189793803845	none			RBPJ_1_1011	Context-specific genetic dependencies (84)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KALS1_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-85	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.641649935719283	none			RBPJ_1_1011	Context-specific genetic dependencies (85)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-86	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.10935924502488	none			RBPJ_1_1011	Context-specific genetic dependencies (86)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KM12_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-87	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.121832897677626	none			RBPJ_1_1011	Context-specific genetic dependencies (87)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-88	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.545112923378882	none			RBPJ_1_1011	Context-specific genetic dependencies (88)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KNS60_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-89	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.0276752369883688	none			RBPJ_1_1011	Context-specific genetic dependencies (89)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KNS81_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-9	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.301695803460557	none			RBPJ_1_1011	Context-specific genetic dependencies (9)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A673_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-90	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.337156628673645	none			RBPJ_1_1011	Context-specific genetic dependencies (90)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KP1NL_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-91	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.541964004847332	none			RBPJ_1_1011	Context-specific genetic dependencies (91)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KP2_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-92	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.622739825198209	none			RBPJ_1_1011	Context-specific genetic dependencies (92)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KP4_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-93	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.124087061339804	none			RBPJ_1_1011	Context-specific genetic dependencies (93)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KURAMOCHI_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-94	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.337703181337825	none			RBPJ_1_1011	Context-specific genetic dependencies (94)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KYSE150_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-95	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	1.25231435846655	none			RBPJ_1_1011	Context-specific genetic dependencies (95)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KYSE30_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-96	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.0967018070226148	none			RBPJ_1_1011	Context-specific genetic dependencies (96)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KYSE450_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-97	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.508957844015854	none			RBPJ_1_1011	Context-specific genetic dependencies (97)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KYSE510_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-98	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	-0.960101668049717	none			RBPJ_1_1011	Context-specific genetic dependencies (98)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	L33_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-99	3516		RBPJ	TRCN0000016203, TRCN0000016206, TRCN0000016207	0.251570063428962	none			RBPJ_1_1011	Context-specific genetic dependencies (99)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
	3516	3516	RBPJ		-0.13	none
GR00371-A-1	3516	3516	RBPJ		1.14566935064	none			Ambion	Nanog expression in absence of bFGF and TGFbeta	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-2	3516	RBPJ	3516		0.865542341069	none			Ambion	Nanog expression in presence of TGFbeta inhibitor	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-3	3516	3516	RBPJ		-0.570052821357	none			Ambion	Nanog expression in presence of MEK inhibitor	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-4	3516	3516	RBPJ		1.02036173744	none			Ambion	Nanog expression in presence of PI3K inhibitor	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-5	3516	3516	RBPJ		-0.957870467942	none			Ambion	Nanog expression in presence of retinoic acid	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00376-A-1	3516	3516	RBPJ		0.17120416	none				Mitigators of SS1P-induced immunotoxicity	Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity	Pasetto et al.	2015	25713356	Cell line	KB cells	Viability	Luminescence	Ambion Silencer Select Version 4	Genome-wide	siRNA	RSA P-value	<0.001	SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID
GR00376-A-2	3516	3516	RBPJ		0.514667249	none				Sensitizers of SS1P-induced immunotoxicity	Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity	Pasetto et al.	2015	25713356	Cell line	KB cells	Viability	Luminescence	Ambion Silencer Select Version 4	Genome-wide	siRNA	RSA P-value	<0.001	SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID
GR00378-A	3516		RBPSUH		0.62419381	none				Poliovirus vaccine production	Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game	van der Sanden et al.	2015	26581994	Cell line	HEp-2C	Infection with Attenuated Poliovirus	ELISA	Dharmacon	Genome-wide	siRNA	Z-score	>	For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol
	3516	NM_005349	RBPJ		42.215	none
GR00386-A-1	3516	3516	RBPJ		94.6094961638543	none				NOD2 stimulation by MDP	A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion.	Warner et al.	2014	25170077	Cell line	HEK293 stably expressing NOD2	Viability	Luminescence	Dharmacon	Genome-wide	siRNA	Percentage growth	Decreased: <70, increased: >120	Reagent IDs not provided
GR00386-A-2	3516	3516	RBPJ		16.1	none				MDP-induced IL-8 secretion	A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion.	Warner et al.	2014	25170077	Cell line	HEK293 stably expressing NOD2	IL-8 secretion	ELISA	Dharmacon	Genome-wide	siRNA	Percent inhibition of IL-8 secretion	Increased: <-300, Decreased: >60	Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided