RNAi

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 3643
  • Symbol: INSR
  • Description: insulin receptor
DataSource: http://genomernai.dkfz.de/v16/genedetails/3643

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Stable_ID Entrez_ID Gene_ID Gene_Symbol Reagent_ID Score Phenotype Conditions Follow_Up Comment Screen_Title Publication_Title Authors Publication_Year Pubmed_ID Biosource Biomodel Assay Method Library Scope Reagent_Type Score_Type Cutoff Notes
GR00016-A 3643 3643 INSR np 1.61 none no Wnt/beta-catenin pathway regulation Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. James et al. 2009 19471023 Cell line RKO Wnt/beta-catenin pathway reporter Luminescence rp Selected genes siRNA Z-score > 2
GR00053-A 3643 NM_000208 INSR np sp none no Genome stability A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Paulsen et al. 2009 19647519 Cell line HeLa gamma-H2AX phosphorylation and DNA content Fluorescence siARRAY human genome siRNA library Genome-wide siRNA p-value Complex criteria Confidence groupings from 4 to 1 (highest level of confidence in group 4)
GR00054-A 3643 NM_000208 INSR np 0.86 none no Combinatorial effect with paclitaxel Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Whitehurst et al. 2007 17429401 Cell line NCI-H1155 Viability (synthetic lethal) ATP level # G-005000-01 Genome-wide siRNA Paclitaxel/control ratio Complex criteria Additional information about 87 high-confidence hits
3643 3643 INSR np np none no
GR00056-A 3643 NM_000208 INSR np 1.109 none no Melanogenesis Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. Ganesan et al. 2008 19057677 Cell line MNT-1 Melanin protein expression and viability Absorbance and luminescence rp Genome-wide siRNA Normalized absorbance ratio > 2 standard deviations below mean Additional information about a secondary screen (retest to determine false-positive rate)
GR00057-A-1 3643 NM_000208 INSR M-003014-01 0.94 none no Wnt/beta-catenin pathway regulation (1) A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Tang et al. 2008 18621708 Cell line HeLa Wnt pathway reporter Luminescence Human siArray siRNA library Genome-wide siRNA Z-score > 4 Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00057-A-2 3643 NM_000208 INSR M-003014-01 sp none no Wnt/beta-catenin pathway regulation (2) A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Tang et al. 2008 18621708 Cell line HeLa Wnt pathway reporter Luminescence Human siArray siRNA library Genome-wide siRNA Complex, SP Complex criteria Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00095-A 3643 NM_000208 INSR np np none p53 pathway components A large-scale RNAi screen in human cells identifies new components of the p53 pathway Berns et al. 2004 15042092 Cell line BJ-TERT-tsLT fibroblasts Proliferation Colony-forming cell assay Nki library Genome-wide shRNA np np
GR00098-A-1 3643 ENSG00000171105 INSR ENSG00000171105 sp Increased G1 DNA content yes did not validate with resynthesized esiRNA Cell division (1) Genome-scale RNAi profiling of cell division in human tissue culture cells. Kittler et al. 2007 17994010 Cell line HeLa Cell number and DNA content Laser scanning cytometry rp Genome-wide esiRNA Complex, sp Complex criteria
GR00098-A-3 3643 ENSG00000171105 INSR ENSG00000171105 -0.5 none yes Cell division (3) Genome-scale RNAi profiling of cell division in human tissue culture cells. Kittler et al. 2007 17994010 Cell line HeLa Histone H3 phosphorylation; alpha-tubulin and pericentrin protein expression Fluorescence rp Selected genes esiRNA Mitotic index >
GR00098-A-4 3643 ENSG00000171105 INSR ENSG00000171105 1.5 none no Cell division (4) Genome-scale RNAi profiling of cell division in human tissue culture cells. Kittler et al. 2007 17994010 Cell line HeLa Cell size (forward scatter) Flow cytometry rp Selected genes esiRNA Cell size >
GR00103-A-0 3643 INSR v2HS_77244 -1.15 Increased cell death in HCC-1954 cells no Cell viability Cancer proliferation gene discovery through functional genomics. Schlabach et al. 2008 18239126 Cell line DLD-1, HCT116; HCC1954; HMECs (mammary epithelia cells) Cell viability Micoarray hybridization shRNA-mir (G. Hannon) shRNA log ratio <
GR00103-A-0 3643 INSR v2HS_77244 -1.44 Increased cell death HMECs cells no Cell viability Cancer proliferation gene discovery through functional genomics. Schlabach et al. 2008 18239126 Cell line DLD-1, HCT116; HCC1954; HMECs (mammary epithelia cells) Cell viability Micoarray hybridization shRNA-mir (G. Hannon) shRNA log ratio <
GR00105-A-0 3643 INSR np 74% Decreased viability in HMC1.1 cells no Cell viability RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia. Tyner et al. 2008 18025156 Cell line CMK, HMC1.1 (white blood cells) Cell viability Cell viability (CellTiter 96) Dharmacon (tyrosine kinases) siRNA % viability np
GR00113-A-0 3643 INSR np np Paclitaxel antagonistic effect no Anticancer drug enhancers Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Swanton et al. 2007 17560332 Cell line A549, HCT116, MDA-MB-231 Cell viability ATP levels Dharmacon (kinases) siRNA np Significant effect in at least 2 of 3 cell lines
GR00114-A 3643 INSR np -0.27 none 102% Combinatorial effect with Poly (ADP‐ribose)‐polymerase‐1 (PARP) A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. Turner et al. 2008 18388863 Cell line CAL51 Viability Luminescence siARRAY SMARTpool Kinases siRNA Z-score < Growth rates (%) for vehicle-alone experiments are given in the comment field.
GR00123-A 3643 NM_000208 INSR 100642, 100641, 100643 np none Combinatorial effect with nutlin-3 An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors Brummelkamp et al. 2006 16474381 Cell line MCF-7 Viability Fluoresence Nki library Genome-wide shRNA log2 ratio np
GR00133-A-1 3643 3643 INSR np 0.004456 none no Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Misselwitz et al. 2011 21407211 Cell line HeLa Gentamycin protection invasion assay Fluorescence Druggable genome library V2.0 Druggable genes siRNA log2 median Complex criteria
GR00141-A 3643 NM_000208 INSR np np none no T cell chemotaxis Synaptotagmin-mediated vesicle fusion regulates cell migration. Colvin et al. 2010 20473299 Cell line SupT1 Cell migration Fluorescence shRNA Library Kinases, phosphatases and selected genes shRNA Chemotactic index > 1 standard deviation from plate mean by at least 2 shRNAs
GR00149-A-1 3643 3643 INSR 29 -1.74 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 3643 3643 INSR 29 -15.72 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 3643 3643 INSR 103297 -38.36 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 3643 3643 INSR 103297 -78.76 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 3643 3643 INSR 103384 -38.71 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1 3643 3643 INSR 103384 40.12 none no Ciliogenesis and cilium length (1) Functional genomic screen for modulators of ciliogenesis and cilium length. Kim et al. 2010 20393563 Cell line htRPE Smoothed protein expression Fluorescence Human druggable genome siRNA library V3.1 Druggable genes siRNA Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean
GR00151-A-1 3643 ENSG00000171105 INSR np -0.926 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (1) A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. SÅ‚abicki et al. 2010 20613862 Cell line HeLa (HR-DSBR) DR-GFP reporter Flow cytometry Custom-made Genome-wide esiRNA Z-score < -2 OR > 2
GR00155-A 3643 3643 INSR INSR_1, INSR_2, INSR_3 np none no Aryl hydrocarbon receptor (AhR) transduction pathway regulation RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity. Gilot et al. 2011 21479225 Cell line MCF-7 TCDD-induced CYP1A1-related EROD activity and cell viability Fluorescence and methylene blue MISSION siRNA Human Kinase Panel library Kinases siRNA Z-score Top 150 for >
GR00180-A-1 3643 3643 INSR PL-50002 0.856 none no Hepatitis C virus replication (1) A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Tai et al. 2009 19286138 Cell line Huh7/Rep-Feo HCV replicon RNA copy number Luminescence siARRAY Human Genome siRNA Library Genome-wide siRNA q-value Complex criteria
GR00184-A-1 3643 NM_000208 INSR M-003014-01 -0.898025621775462 none no Self-renewal and pluripotency in human embryonic stem cells (1) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 POU5F1 protein expression Fluorescence SMARTpool siRNA library Genome-wide siRNA Z-score < -2
GR00193-A-1 3643 3643 INSR INSR 0.557670695940575 none yes Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (1) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line EBC1 Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00193-A-2 3643 3643 INSR INSR 0.738943752683555 none yes Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (2) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line KELLY Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00193-A-3 3643 3643 INSR INSR 0.650351140874571 Decreased substrate adherent cell growth yes Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (3) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line SKNAS Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00193-A-4 3643 3643 INSR INSR 0.499302036880158 Decreased substrate adherent cell growth no Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (4) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line NLF Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00197-A-1 3643 3643 INSR M-003014-01 0.581891414 none no Human papillomavirus oncogene expression regulation (1) Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Smith et al. 2010 20133580 Cell line C33A/BE2/18LCR c4 HPV18 LCR reporter activity Luminescence Human siGENOME SMARTpool library Genome-wide siRNA Z-score > Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5
GR00210-A 3643 3643 INSR np sp none no Focal adhesion formation Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown. Winograd-Katz et al. 2009 19667130 Cell line HeLa paxillin protein expression Fluorescence SMARTpool siARRAY siRNA Libraries Kinases, phosphatases and selected genes siRNA Z-score > 3.5 OR < -3.5
GR00221-A-1 3643 INSR TRCN0000039701 -1.1 Decreased viability yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 3643 INSR TRCN0000000379 -0.93 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 3643 INSR TRCN0000000381 0.1 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 3643 INSR TRCN0000039698 0.26 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 3643 INSR TRCN0000000382 0.51 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 3643 INSR TRCN0000039702 0.52 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 3643 INSR TRCN0000039699 0.59 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 3643 INSR TRCN0000039700 1.12 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 3643 INSR TRCN0000000379 -1.41 Decreased viability yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 3643 INSR TRCN0000039698 -0.29 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 3643 INSR TRCN0000039702 -0.05 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 3643 INSR TRCN0000000380 0 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 3643 INSR TRCN0000039701 0.07 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 3643 INSR TRCN0000039699 0.41 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 3643 INSR TRCN0000039700 0.51 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 3643 INSR TRCN0000000382 0.58 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 3643 INSR TRCN0000000381 0.6 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 3643 INSR TRCN0000000381 -1.15 Decreased viability yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 3643 INSR TRCN0000039699 -0.56 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 3643 INSR TRCN0000039698 -0.35 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 3643 INSR TRCN0000000382 0.02 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 3643 INSR TRCN0000039700 0.2 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 3643 INSR TRCN0000039702 0.65 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 3643 INSR TRCN0000000380 0.73 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 3643 INSR TRCN0000039701 0.93 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 3643 INSR TRCN0000000379 1.43 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 3643 INSR TRCN0000000382 -1.21 Decreased viability no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 3643 INSR TRCN0000039698 -0.6 none no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 3643 INSR TRCN0000039701 -0.55 none no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 3643 INSR TRCN0000039702 -0.27 none no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 3643 INSR TRCN0000039699 -0.2 none no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 3643 INSR TRCN0000000381 -0.14 none no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 3643 INSR TRCN0000039700 0.19 none no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 3643 INSR TRCN0000000380 0.6 none no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 3643 INSR TRCN0000000379 0.75 none no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
3643 NM_000208 INSR np 1.095211 none no
GR00230-A-1 3643 NM_000208 INSR TRCN0000000380 -3.63 Decreased cell viability after pRB stimulation yes pRB-induced cell cycle regulation (1) A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Tschöp et al. 2011 21498571 Cell line SaOS2-TR-pRB Cell number and viability Colorimetrics Lentiviral shRNA library Kinases shRNA SD from the trendline > 3.0 OR < -3.0 for >
GR00230-A-1 3643 NM_000208 INSR TRCN0000000381 -3.19 Decreased cell viability after pRB stimulation yes pRB-induced cell cycle regulation (1) A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Tschöp et al. 2011 21498571 Cell line SaOS2-TR-pRB Cell number and viability Colorimetrics Lentiviral shRNA library Kinases shRNA SD from the trendline > 3.0 OR < -3.0 for >
GR00231-A 3643 NM_000208 INSR M-003014-01 0.85 none yes Cell proliferation Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation. Zhang et al. 2011 21765947 Cell line HeLa Viability Electrical impedance Human siARRAY - Protein Kinase and Cell Cycle libraries Kinases and selected genes siRNA Z-score < -1.96 OR > 1.96 Additional information about cell titer blue cell viability screen
3643 INSR np np Decreased viability in esophageal squamous lineage no esophageal squamous: no filter, 2nd best
GR00236-A-1 3643 3643 INSR M-003014-01 0.738820162734308 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (1) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Adamson et al. 2012 22344029 Cell line DR-U2OS (HR-DSBR) DR-GFP reporter and DNA content Fluorescence Human siGENOME siRNA (G-005000-05) Genome-wide siRNA Relative HR ratio < ~0.4 OR > 1.88 Cutoff values correspond 2 standard deviations from the screen-wide mean
GR00240-S-1 3643 NM_000208 INSR M-003014-01 -0.12 none yes TRAIL-induced apoptosis (1) A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. Kranz and Boutros 2014 24442637 Cell line U251MG Viability Luminescence SMART-pool siRNA Genome-wide siRNA Z-score > 4 Author-submitted data
GR00240-S-2 3643 NM_000208 INSR M-003014-01 -0.07 none no Z-score -0.211 TRAIL-induced apoptosis (2) A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. Kranz and Boutros 2014 24442637 Cell line U251MG Viability (synthetic lethal) Luminescence SMART-pool siRNA Genome-wide siRNA Differential score > 3.6 AND viability Z-score < 4 Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen.
GR00242-A-1 3643 NM_000208 INSR np sp none no Selective autophagy regulation (1) Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl et al. 2011 22020285 Cell line HeLa/GFP-LC3 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression Fluorescence siGenome Genome-wide siRNA Z-score Complex criteria
GR00247-A-1 3643 INSR np sp none rank: 14904 Regulation of FOXO1 nuclear localization (1) Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Senapedis et al. 2011 21460183 Cell line U2OS EGFP-FOXO1a protein expression and DNA content Fluorescence Human Genome library Genome-wide siRNA Complex, sp Complex criteria
GR00248-A 3643 NM_000208 INSR INSR_siRNA1 2.665 Increased human cytomegalovirus (HCMV) strain AD169 replication gene: increased replication Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00248-A 3643 NM_000208 INSR INSR_siRNA2 0.693 none gene: increased replication Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00248-A 3643 NM_000208 INSR INSR_siRNA3 3.508 Increased human cytomegalovirus (HCMV) strain AD169 replication gene: increased replication Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00249-S 3643 3643 INSR J-003014-13 4.23416 Increased vaccinia virus (VACV) infection no number of cells compared to control (%): 56.47 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 3643 3643 INSR M-003014-02 -1.28557 none no number of cells compared to control (%): 55.64 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 3643 3643 INSR s7477 -1.43369 none no number of cells compared to control (%): 76.93 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 3643 3643 INSR s7478 0.56081 none no number of cells compared to control (%): 77.62 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 3643 3643 INSR s7479 -1.43499 none no number of cells compared to control (%): 83.74 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00253-A 3643 NM_000208 INSR np -0.466 none hepcidin regulation Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Mleczko-Sanecka et al. 2014 24385536 Cell line Huh7 hepcidin::fluc mRNA expression Luminescence siGenome siARRAY SMARTpool Genome-wide siRNA Z-score > Cutoff <
GR00255-A-1 3643 3667 IRS1 TRCN0000009843, TRCN0000009844, TRCN0000039908, TRCN0000039909, TRCN0000039910, TRCN0000039911, TRCN0000039912 -0.130408012 none Negative genetic interactions (1) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-1 3643 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000010523, TRCN0000018332, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701, TRCN0000039702, TRCN0000121123, TRCN0000121124, TRCN0000121125, TRCN0000121126, TRCN0000121217, TRCN0000121218, TRCN0000121219, TRCN0000121220, TRCN0000121221, TRCN0000121282, TRCN0000121283, TRCN0000121284, TRCN0000121286 -0.902505855 none Negative genetic interactions (1) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-2 3643 3667 IRS1 TRCN0000009843, TRCN0000009844, TRCN0000039908, TRCN0000039909, TRCN0000039910, TRCN0000039911, TRCN0000039912 -0.438451751 none Negative genetic interactions (2) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-2 3643 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000010523, TRCN0000018332, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701, TRCN0000039702, TRCN0000121123, TRCN0000121124, TRCN0000121125, TRCN0000121126, TRCN0000121217, TRCN0000121218, TRCN0000121219, TRCN0000121220, TRCN0000121221, TRCN0000121282, TRCN0000121283, TRCN0000121284, TRCN0000121286 -1.383331199 Negative genetic interaction between MUS81-/- and MUS81+/+ Negative genetic interactions (2) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-3 3643 3667 IRS1 TRCN0000009843, TRCN0000009844, TRCN0000039908, TRCN0000039909, TRCN0000039910, TRCN0000039911, TRCN0000039912 -3.298119116 Negative genetic interaction between PTEN-/- and PTEN+/+ Negative genetic interactions (3) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-3 3643 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000010523, TRCN0000018332, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701, TRCN0000039702, TRCN0000121123, TRCN0000121124, TRCN0000121125, TRCN0000121126, TRCN0000121217, TRCN0000121218, TRCN0000121219, TRCN0000121220, TRCN0000121221, TRCN0000121282, TRCN0000121283, TRCN0000121284, TRCN0000121286 -1.160213633 none Negative genetic interactions (3) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-4 3643 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000010523, TRCN0000018332, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701, TRCN0000039702, TRCN0000121123, TRCN0000121124, TRCN0000121125, TRCN0000121126, TRCN0000121217, TRCN0000121218, TRCN0000121219, TRCN0000121220, TRCN0000121221, TRCN0000121282, TRCN0000121283, TRCN0000121284, TRCN0000121286 -1.191287162 none Negative genetic interactions (4) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-4 3643 3667 IRS1 TRCN0000009843, TRCN0000009844, TRCN0000039908, TRCN0000039909, TRCN0000039910, TRCN0000039911, TRCN0000039912 -1.713632272 Negative genetic interaction between PTTG1-/- and PTTG1+/+ Negative genetic interactions (4) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-5 3643 3667 IRS1 TRCN0000009843, TRCN0000009844, TRCN0000039908, TRCN0000039909, TRCN0000039910, TRCN0000039911, TRCN0000039912 -0.133303138 none Negative genetic interactions (5) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -0.8 HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-5 3643 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000010523, TRCN0000018332, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701, TRCN0000039702, TRCN0000121123, TRCN0000121124, TRCN0000121125, TRCN0000121126, TRCN0000121217, TRCN0000121218, TRCN0000121219, TRCN0000121220, TRCN0000121221, TRCN0000121282, TRCN0000121283, TRCN0000121284, TRCN0000121286 0.759267996 none Negative genetic interactions (5) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -0.8 HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00256-A 3643 NM_000208 IKBKG np sp none Kinase-mediated spindle orientation ABL1 regulates spindle orientation in adherent cells and mammalian skin. Matsumara et al. 2012 22252550 Cell line HeLa beta-tubulin protein expression and DNA content Fluorescence Silencer Kinase siRNA library (AM80010V3) Kinases siRNA Complex, sp Complex criteria HeLa cells stably expressing GFP-H2B (HeLa-GH2B) used. Additional information about secondary screens.
GR00293-A 3643 INSR np 1.022 none Combinatorial effect with paclitaxel Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death Sinnott et al. 2014 24860162 Cell line HCC366 Viability Luminescence Thermo-Fisher Genome-wide siRNA Z-score < -2.5 Final hits according to the author are indicated in the comment.
GR00300-A 3643 IRS1 TRCN0000039912, TRCN0000039911, TRCN0000039910, TRCN0000009843, TRCN0000009844, TRCN0000039908, TRCN0000039909 0 none Combinatorial effect with RAF inhibitor PLX4720 A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Whittaker et al. 2013 23288408 Cell line A375 shRNA abundance Sequencing TRC Genome-wide shRNA Number of shRNAs ranked Top1000 > 2 The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors.
GR00300-A 3643 INSR TRCN0000194847, TRCN0000195635, TRCN0000000379, TRCN0000195618, TRCN0000121221, TRCN0000121220, TRCN0000121217, TRCN0000121219, TRCN0000121218, TRCN0000000382, TRCN0000121282, TRCN0000121283, TRCN0000018332, TRCN0000000380, TRCN0000121284, TRCN0000000381, TRCN0000121286, TRCN0000010523, TRCN0000121123, TRCN0000121125, TRCN0000121124, TRCN0000121126, TRCN0000199622, TRCN0000196786, TRCN0000039700, TRCN0000039701, TRCN0000039702, TRCN0000039698, TRCN0000039699 0 none Combinatorial effect with RAF inhibitor PLX4720 A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Whittaker et al. 2013 23288408 Cell line A375 shRNA abundance Sequencing TRC Genome-wide shRNA Number of shRNAs ranked Top1000 > 2 The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors.
GR00303-A 3643 NM_000208 INSR np -1.16 none Clear cell renal cell carcinoma (ccRCC) survival regulation Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target Gerlinger et al. 2012 22362593 Cell line VHL-deficient RCC4 Proliferation and Viability Fluorescence np Genome-wide siRNA Z-score < In the phenotype data duplicates were in the original document, which have been removed.
GR00310-A-1 3643 3643 INSR np 0.85 none Sindbis virus (SINV) infection (1) Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry Ooi et al. 2013 24367265 Cell line U2OS Sindbis virus (SINV) reporter Luminescence Ambion Silencer V3 Genome-wide siRNA Z-score < -3 OR > 2
3643 3643 INSR np 20.2 none 104,1% viability
GR00313-A 3643 NM_000208 INSR np -0.36 none TNF-alpha pathway regulation A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. Nickles et al. 2012 22733992 Cell line HEK293T NFkappaB pathway reporter Luminescence Qiagen Genome-wide siRNA Z-score < Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%.
GR00318-A 3643 3643 INSR np 1.124 none siRNA set: kinase Huntingtin toxicity A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease Miller et al. 2012 23209424 Cell line HEK293T Caspase 3/7 activity Fluorescence Dharmacon Selected genes siRNA Sum of normalized caspase 3/7 activity mean and standard error < 0.683 HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP).
GR00327-A 3643 3643 PAPSS2 CLL-H-019084 0.43706419240354233 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 3643 3643 PAPSS2 CLL-H-019082 -1.7691302310370565 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 3643 3643 PAPSS2 CLL-H-019085 1.2685016754507594 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 3643 3643 PAPSS2 CLL-H-019081 -0.9022901531884102 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 3643 3643 PAPSS2 CLL-H-019083 -0.3662479688499034 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00342-S-1 3643 INSR M-003014-01 -0.8185113252944167 none Viability of Mesenchymal Stem Cells (MSC) (1) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 1, MSC preparation 1 (MSC1a)
GR00342-S-2 3643 INSR M-003014-01 -0.7742146554629983 none Viability of Mesenchymal Stem Cells (MSC) (2) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 1, MSC preparation 2 (MSC1b)
GR00342-S-3 3643 INSR M-003014-01 -0.7254580957846284 none Viability of Mesenchymal Stem Cells (MSC) (3) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 2, MSC preparation 1 (MSC2)
GR00343-S 3643 3643 INSR TRCN0000018332 0.03750000000000053 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 3643 3643 INSR TRCN0000000379 -0.46749999999999936 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 3643 3643 INSR TRCN0000000382 1.58 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 3643 3643 INSR TRCN0000000380 0.5975000000000019 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 3643 3643 INSR TRCN0000039698 0.042500000000000426 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 3643 3643 INSR TRCN0000039701 0.9150000000000009 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 3643 3643 INSR TRCN0000039700 0.5949999999999989 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 3643 3643 INSR TRCN0000039702 0.13000000000000078 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 3643 3643 INSR TRCN0000000381 -0.07249999999999979 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 3643 3643 INSR TRCN0000039699 -0.2875000000000014 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00356-A-1 3643 NM_000208 INSR np 0.9 none Clathrin-mediated endocytosis Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Pelkmans et al. 2005 15889048 Cell line HeLa Vesicular stomatitis virus (VSV) infection (rVSV–GFP expression) Fluorescence Ambion Kinases siRNA Relative infection index (RII) < The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Caveolin- and lipid raft-mediated endocytosis" using simian virus 40 (SV40).
GR00356-A-2 3643 NM_000208 INSR np 1.0001000173629155 none Caveolin- and lipid raft-mediated endocytosis Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Pelkmans et al. 2005 15889048 Cell line HeLa Simian virus 40 (SV40) infection (SV40 large T-antigen expression) Fluorescence Ambion Kinases siRNA Relative infection index (RII) < The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Clathrin-mediated endocytosis" using vesicular stomatitis virus (VSV).
GR00356-A-3 3643 NM_000208 INSR np np none Endocytosis regulation Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Pelkmans et al. 2005 15889048 Cell line HeLa Transferrin (Tfn) uptake and trafficking Fluorescence Ambion Kinases siRNA np np
GR00363-A 3643 3643 INSR 103467, SI00004508, SI03115434, SI03024581, 103384, esi12566, SI00004522, 103297 sp Increased epidermal growth factor (EGF) endocytosis, increased transferrin (TF) endocytosis strong Endocytosis regulation Systems survey of endocytosis by multiparametric image analysis. Collinet et al. 2010 20190736 Cell line HeLa Transferrin (TF) and epidermal growth factor (EGF) subcellular localisation, DNA content Fluorescence Ambion, Qiagen and esiRNA library (Kittler et al.) Genome-wide siRNA Complex, sp Complex criteria Two hit categories: "strong" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn > 0.95) and "weak but specific" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn < 0.95 but Phenoscore > 0.95). Additional information about secondary screens with kinase and phospatase libraries.
GR00366-A-1 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.109231018763261 none INSR_1_111101111 Context-specific genetic dependencies (1) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 22RV1_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-10 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.450956682221875 none INSR_1_111101111 Context-specific genetic dependencies (10) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ACHN_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-100 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 1.03645785731882 none INSR_1_111101111 Context-specific genetic dependencies (100) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-101 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.260621581778077 none INSR_1_111101111 Context-specific genetic dependencies (101) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LK2_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-102 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0938951973881168 none INSR_1_111101111 Context-specific genetic dependencies (102) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN215_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-103 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0720342268895567 none INSR_1_111101111 Context-specific genetic dependencies (103) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN229_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-104 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.141440904199093 none INSR_1_111101111 Context-specific genetic dependencies (104) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN235_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-105 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0689484814184195 none INSR_1_111101111 Context-specific genetic dependencies (105) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN319_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-106 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.327208960331371 none INSR_1_111101111 Context-specific genetic dependencies (106) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN340_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-107 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.343073781699345 none INSR_1_111101111 Context-specific genetic dependencies (107) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN382_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-108 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.515049368707563 none INSR_1_111101111 Context-specific genetic dependencies (108) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN428_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-109 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.20044805032398 none INSR_1_111101111 Context-specific genetic dependencies (109) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN443_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-11 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.576201539499502 none INSR_1_111101111 Context-specific genetic dependencies (11) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AGS_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-110 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.660869380860399 none INSR_1_111101111 Context-specific genetic dependencies (110) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN464_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-111 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0740222582491952 none INSR_1_111101111 Context-specific genetic dependencies (111) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LNZ308_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-112 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.636903715152392 none INSR_1_111101111 Context-specific genetic dependencies (112) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LOVO_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-113 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.913658579035892 none INSR_1_111101111 Context-specific genetic dependencies (113) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LS411N_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-114 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.220915149650152 none INSR_1_111101111 Context-specific genetic dependencies (114) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LS513_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-115 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.00758737211047478 none INSR_1_111101111 Context-specific genetic dependencies (115) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MCF7_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-116 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.358720625302763 none INSR_1_111101111 Context-specific genetic dependencies (116) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MDAMB453_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-117 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.307076135896539 none INSR_1_111101111 Context-specific genetic dependencies (117) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MIAPACA2_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-118 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.11249981117087 none INSR_1_111101111 Context-specific genetic dependencies (118) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MKN7_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-119 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -1.01761872021118 none INSR_1_111101111 Context-specific genetic dependencies (119) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-12 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0106388647680725 none INSR_1_111101111 Context-specific genetic dependencies (12) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AM38_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-120 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.571112730096508 none INSR_1_111101111 Context-specific genetic dependencies (120) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-121 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.787089375619792 none INSR_1_111101111 Context-specific genetic dependencies (121) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-122 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.525451503376477 none INSR_1_111101111 Context-specific genetic dependencies (122) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-123 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.323249915599851 none INSR_1_111101111 Context-specific genetic dependencies (123) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-124 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.227150317319836 none INSR_1_111101111 Context-specific genetic dependencies (124) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-125 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.216488964487936 none INSR_1_111101111 Context-specific genetic dependencies (125) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-126 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.133360124635527 none INSR_1_111101111 Context-specific genetic dependencies (126) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1299_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-127 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.157593635969498 none INSR_1_111101111 Context-specific genetic dependencies (127) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1437_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-128 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.29705804368927 none INSR_1_111101111 Context-specific genetic dependencies (128) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1650_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-129 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.194675992414427 none INSR_1_111101111 Context-specific genetic dependencies (129) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1792_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-13 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.458090833609297 none INSR_1_111101111 Context-specific genetic dependencies (13) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-130 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.160219274790967 none INSR_1_111101111 Context-specific genetic dependencies (130) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH196_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-131 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.285392099453265 none INSR_1_111101111 Context-specific genetic dependencies (131) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1975_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-132 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.49507686497768 none INSR_1_111101111 Context-specific genetic dependencies (132) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2052_PLEURA shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-133 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.087627201011769 none INSR_1_111101111 Context-specific genetic dependencies (133) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2122_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-134 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0577972032471814 none INSR_1_111101111 Context-specific genetic dependencies (134) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2171_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-135 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.678717509058268 none INSR_1_111101111 Context-specific genetic dependencies (135) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH23_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-136 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.747632302466618 none INSR_1_111101111 Context-specific genetic dependencies (136) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2452_PLEURA shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-137 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.173865764314205 none INSR_1_111101111 Context-specific genetic dependencies (137) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH441_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-138 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.831154408009859 none INSR_1_111101111 Context-specific genetic dependencies (138) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH508_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-139 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.659955585536152 none INSR_1_111101111 Context-specific genetic dependencies (139) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH660_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-14 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.343848986761245 none INSR_1_111101111 Context-specific genetic dependencies (14) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ASPC1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-140 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.619010422317745 none INSR_1_111101111 Context-specific genetic dependencies (140) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH661_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-141 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.11379680718006 none INSR_1_111101111 Context-specific genetic dependencies (141) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH716_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-142 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 1.63335531255816 Increased shRNA abundance (Z-score > 2) INSR_1_111101111 Context-specific genetic dependencies (142) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH838_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-143 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.83208331043512 none INSR_1_111101111 Context-specific genetic dependencies (143) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIN87_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-144 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.408878413248355 none INSR_1_111101111 Context-specific genetic dependencies (144) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NIHOVCAR3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-145 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.870054381916067 none INSR_1_111101111 Context-specific genetic dependencies (145) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-146 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.627178343802483 none INSR_1_111101111 Context-specific genetic dependencies (146) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OAW42_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-147 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.143612527158151 none INSR_1_111101111 Context-specific genetic dependencies (147) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-148 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0403029170759432 none INSR_1_111101111 Context-specific genetic dependencies (148) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-149 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.738197896768111 none INSR_1_111101111 Context-specific genetic dependencies (149) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-15 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.55227580587761 none INSR_1_111101111 Context-specific genetic dependencies (15) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BT20_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-150 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.639226835077633 none INSR_1_111101111 Context-specific genetic dependencies (150) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OE33_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-151 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.578676902494707 none INSR_1_111101111 Context-specific genetic dependencies (151) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OELE_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-152 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.198592897751136 none INSR_1_111101111 Context-specific genetic dependencies (152) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-153 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.298686289931543 none INSR_1_111101111 Context-specific genetic dependencies (153) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OV7_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-154 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.380046452596347 none INSR_1_111101111 Context-specific genetic dependencies (154) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OV90_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-155 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.434839784867332 none INSR_1_111101111 Context-specific genetic dependencies (155) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVCAR4_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-156 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0530504459682459 none INSR_1_111101111 Context-specific genetic dependencies (156) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVCAR8_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-157 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.540768763829963 none INSR_1_111101111 Context-specific genetic dependencies (157) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVISE_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-158 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.182041475574712 none INSR_1_111101111 Context-specific genetic dependencies (158) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC0327_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-159 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.386803998279065 none INSR_1_111101111 Context-specific genetic dependencies (159) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC0813_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-16 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.338406611490979 none INSR_1_111101111 Context-specific genetic dependencies (16) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BT474_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-160 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.878491742794821 none INSR_1_111101111 Context-specific genetic dependencies (160) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC1005_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-161 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.307630358189221 none INSR_1_111101111 Context-specific genetic dependencies (161) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-162 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.175420260896544 none INSR_1_111101111 Context-specific genetic dependencies (162) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PSN1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-163 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.569331684278914 none INSR_1_111101111 Context-specific genetic dependencies (163) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line QGP1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-164 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.107130565083252 none INSR_1_111101111 Context-specific genetic dependencies (164) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-165 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.271779012364626 none INSR_1_111101111 Context-specific genetic dependencies (165) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RKN_SOFT_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-166 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.604336744360796 none INSR_1_111101111 Context-specific genetic dependencies (166) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RKO_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-167 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.562681789968623 none INSR_1_111101111 Context-specific genetic dependencies (167) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RMGI_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-168 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0523172080965957 none INSR_1_111101111 Context-specific genetic dependencies (168) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RMUGS_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-169 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.205646469916068 none INSR_1_111101111 Context-specific genetic dependencies (169) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-17 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.381077585472406 none INSR_1_111101111 Context-specific genetic dependencies (17) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BXPC3_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-170 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.539280485857107 none INSR_1_111101111 Context-specific genetic dependencies (170) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RT112_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-171 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.712763868901104 none INSR_1_111101111 Context-specific genetic dependencies (171) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-172 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.129775069555058 none INSR_1_111101111 Context-specific genetic dependencies (172) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF126_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-173 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 1.04203022317769 none INSR_1_111101111 Context-specific genetic dependencies (173) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF172_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-174 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.310749076478254 none INSR_1_111101111 Context-specific genetic dependencies (174) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF295_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-175 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.7797105002768 none INSR_1_111101111 Context-specific genetic dependencies (175) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF767_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-176 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.786630115860713 none INSR_1_111101111 Context-specific genetic dependencies (176) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SJSA1_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-177 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.53131210042001 none INSR_1_111101111 Context-specific genetic dependencies (177) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKCO1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-178 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.420395717018496 none INSR_1_111101111 Context-specific genetic dependencies (178) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKMEL5_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-179 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.626250282382072 none INSR_1_111101111 Context-specific genetic dependencies (179) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-18 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 1.52368432440718 Increased shRNA abundance (Z-score > 2) INSR_1_111101111 Context-specific genetic dependencies (18) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line C2BBE1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-180 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.134610050354283 none INSR_1_111101111 Context-specific genetic dependencies (180) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-181 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0962304597152655 none INSR_1_111101111 Context-specific genetic dependencies (181) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKOV3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-182 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.101094245214506 none INSR_1_111101111 Context-specific genetic dependencies (182) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKRC20_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-183 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.566187761255865 none INSR_1_111101111 Context-specific genetic dependencies (183) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR20_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-184 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0942332458288913 none INSR_1_111101111 Context-specific genetic dependencies (184) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR21_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-185 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.578081554759008 none INSR_1_111101111 Context-specific genetic dependencies (185) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR23_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-186 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.307726519926209 none INSR_1_111101111 Context-specific genetic dependencies (186) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR24_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-187 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0956531659715922 none INSR_1_111101111 Context-specific genetic dependencies (187) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR25_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-188 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.207247900131798 none INSR_1_111101111 Context-specific genetic dependencies (188) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR26_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-189 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -1.01018894723298 none INSR_1_111101111 Context-specific genetic dependencies (189) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNU1105_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-19 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.954109720040367 none INSR_1_111101111 Context-specific genetic dependencies (19) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line C32_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-190 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.189212862700283 none INSR_1_111101111 Context-specific genetic dependencies (190) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNU840_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-191 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.344155850367343 none INSR_1_111101111 Context-specific genetic dependencies (191) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNUC1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-192 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.153805654469022 none INSR_1_111101111 Context-specific genetic dependencies (192) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNUC2A_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-193 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.518302163386279 none INSR_1_111101111 Context-specific genetic dependencies (193) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SU8686_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-194 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.33529774283821 none INSR_1_111101111 Context-specific genetic dependencies (194) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW1417_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-195 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.126730709363751 none INSR_1_111101111 Context-specific genetic dependencies (195) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW1783_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-196 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 1.19152351356524 Increased shRNA abundance (Z-score > 2) INSR_1_111101111 Context-specific genetic dependencies (196) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW480_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-197 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.258550938797155 none INSR_1_111101111 Context-specific genetic dependencies (197) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW48_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-198 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0749876838994925 none INSR_1_111101111 Context-specific genetic dependencies (198) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line T98G_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-199 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.848473893498693 none INSR_1_111101111 Context-specific genetic dependencies (199) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TC71_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-2 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.570026480762241 none INSR_1_111101111 Context-specific genetic dependencies (2) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-20 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.575016220991996 none INSR_1_111101111 Context-specific genetic dependencies (20) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CADOES1_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-200 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.638608985000847 none INSR_1_111101111 Context-specific genetic dependencies (200) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TCCSUP_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-201 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.1536970967837 none INSR_1_111101111 Context-specific genetic dependencies (201) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE10_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-202 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.345943846370118 none INSR_1_111101111 Context-specific genetic dependencies (202) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE15_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-203 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0966576020508524 none INSR_1_111101111 Context-specific genetic dependencies (203) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE9_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-204 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.46842019424221 none INSR_1_111101111 Context-specific genetic dependencies (204) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-205 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 1.0432872530356 none INSR_1_111101111 Context-specific genetic dependencies (205) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TOV112D_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-206 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0501488224979405 none INSR_1_111101111 Context-specific genetic dependencies (206) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TOV21G_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-207 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0619194242970721 none INSR_1_111101111 Context-specific genetic dependencies (207) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TT_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-208 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.135833195515593 none INSR_1_111101111 Context-specific genetic dependencies (208) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TYKNU_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-209 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.346043735742658 none INSR_1_111101111 Context-specific genetic dependencies (209) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U178_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-21 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.255570745068563 none INSR_1_111101111 Context-specific genetic dependencies (21) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAL120_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-210 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.216252289669139 none INSR_1_111101111 Context-specific genetic dependencies (210) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U251MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-211 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.369325100232704 none INSR_1_111101111 Context-specific genetic dependencies (211) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U343_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-212 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.618730171159384 none INSR_1_111101111 Context-specific genetic dependencies (212) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U87MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-213 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -1.37964620973847 Decreased shRNA abundance (Z-score < -2) INSR_1_111101111 Context-specific genetic dependencies (213) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line UOK101_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-214 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0178019912108419 none INSR_1_111101111 Context-specific genetic dependencies (214) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line VCAP_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-215 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.335427358483132 none INSR_1_111101111 Context-specific genetic dependencies (215) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line YKG1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-216 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.239526343799625 none INSR_1_111101111 Context-specific genetic dependencies (216) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ZR7530_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-22 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.817832599592061 none INSR_1_111101111 Context-specific genetic dependencies (22) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAL51_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-23 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.55040780286367 none INSR_1_111101111 Context-specific genetic dependencies (23) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CALU1_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-24 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.222680387769937 none INSR_1_111101111 Context-specific genetic dependencies (24) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAOV3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-25 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.298384318096543 none INSR_1_111101111 Context-specific genetic dependencies (25) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAOV4_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-26 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.405977799740451 none INSR_1_111101111 Context-specific genetic dependencies (26) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAS1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-27 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.460528316564518 none INSR_1_111101111 Context-specific genetic dependencies (27) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CFPAC1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-28 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0915913625928859 none INSR_1_111101111 Context-specific genetic dependencies (28) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CH157MN_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-29 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.106685410024863 none INSR_1_111101111 Context-specific genetic dependencies (29) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO205_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-3 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.269973656581037 none INSR_1_111101111 Context-specific genetic dependencies (3) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 786O_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-30 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.836802182513298 none INSR_1_111101111 Context-specific genetic dependencies (30) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO704_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-31 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.133204552964917 none INSR_1_111101111 Context-specific genetic dependencies (31) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO741_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-32 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.322175364678369 none INSR_1_111101111 Context-specific genetic dependencies (32) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO783_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-33 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.146864687606214 none INSR_1_111101111 Context-specific genetic dependencies (33) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CORL23_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-34 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0356189136728135 none INSR_1_111101111 Context-specific genetic dependencies (34) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV362_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-35 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.852429826793894 none INSR_1_111101111 Context-specific genetic dependencies (35) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV434_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-36 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.109226582277245 none INSR_1_111101111 Context-specific genetic dependencies (36) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV504_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-37 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.142120484030338 none INSR_1_111101111 Context-specific genetic dependencies (37) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV644_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-38 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.443254405432772 none INSR_1_111101111 Context-specific genetic dependencies (38) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DBTRG05MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-39 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.298477440400417 none INSR_1_111101111 Context-specific genetic dependencies (39) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DKMG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-4 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.114260927070653 none INSR_1_111101111 Context-specific genetic dependencies (4) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A1207_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-40 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 1.37283878820529 Increased shRNA abundance (Z-score > 2) INSR_1_111101111 Context-specific genetic dependencies (40) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DLD1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-41 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.604634052385732 none INSR_1_111101111 Context-specific genetic dependencies (41) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFE184_ENDOMETRIUM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-42 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 1.34417427690927 Increased shRNA abundance (Z-score > 2) INSR_1_111101111 Context-specific genetic dependencies (42) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFM19_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-43 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 1.05241077493072 none INSR_1_111101111 Context-specific genetic dependencies (43) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFO21_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-44 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.120826467791568 none INSR_1_111101111 Context-specific genetic dependencies (44) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFO27_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-45 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.127679752550095 none INSR_1_111101111 Context-specific genetic dependencies (45) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EW8_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-46 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.733638653023332 none INSR_1_111101111 Context-specific genetic dependencies (46) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EWS502_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-47 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.461526025816023 none INSR_1_111101111 Context-specific genetic dependencies (47) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-48 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0589641123011072 none INSR_1_111101111 Context-specific genetic dependencies (48) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line GB1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-49 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.305908024115872 none INSR_1_111101111 Context-specific genetic dependencies (49) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line GP2D_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-5 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.523484188050855 none INSR_1_111101111 Context-specific genetic dependencies (5) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A172_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-50 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0414277970699783 none INSR_1_111101111 Context-specific genetic dependencies (50) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1187_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-51 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0548107051792744 none INSR_1_111101111 Context-specific genetic dependencies (51) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1395_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-52 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0168803891019944 none INSR_1_111101111 Context-specific genetic dependencies (52) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1954_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-53 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.231409537279375 none INSR_1_111101111 Context-specific genetic dependencies (53) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC2218_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-54 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.298149732553774 none INSR_1_111101111 Context-specific genetic dependencies (54) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC2814_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-55 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.172898639033422 none INSR_1_111101111 Context-specific genetic dependencies (55) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC364_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-56 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.455215562940789 none INSR_1_111101111 Context-specific genetic dependencies (56) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC44_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-57 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.189187736997577 none INSR_1_111101111 Context-specific genetic dependencies (57) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC70_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-58 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.60340537091446 none INSR_1_111101111 Context-specific genetic dependencies (58) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC827GR5_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-59 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.275354526889901 none INSR_1_111101111 Context-specific genetic dependencies (59) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC827_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-6 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.328323879206485 none INSR_1_111101111 Context-specific genetic dependencies (6) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A204_SOFT_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-60 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 1.51198346441537 Increased shRNA abundance (Z-score > 2) INSR_1_111101111 Context-specific genetic dependencies (60) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCT116_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-61 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.475588531255426 none INSR_1_111101111 Context-specific genetic dependencies (61) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HEC1A_ENDOMETRIUM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-62 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0469844869033189 none INSR_1_111101111 Context-specific genetic dependencies (62) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HEYA8_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-63 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.562160738234712 none INSR_1_111101111 Context-specific genetic dependencies (63) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-64 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0660110330086834 none INSR_1_111101111 Context-specific genetic dependencies (64) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HLF_LIVER shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-65 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0315503400327277 none INSR_1_111101111 Context-specific genetic dependencies (65) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-66 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.107288026520944 none INSR_1_111101111 Context-specific genetic dependencies (66) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HPAC_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-67 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.225586518327917 none INSR_1_111101111 Context-specific genetic dependencies (67) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HPAFII_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-68 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -1.02500137595859 Decreased shRNA abundance (Z-score < -2) INSR_1_111101111 Context-specific genetic dependencies (68) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS683_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-69 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0249797740683682 none INSR_1_111101111 Context-specific genetic dependencies (69) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS766T_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-7 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.242821766424722 none INSR_1_111101111 Context-specific genetic dependencies (7) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A2058_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-70 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.651399419389258 none INSR_1_111101111 Context-specific genetic dependencies (70) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS944T_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-71 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.63839279395972 none INSR_1_111101111 Context-specific genetic dependencies (71) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT1197_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-72 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.606119327692862 none INSR_1_111101111 Context-specific genetic dependencies (72) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT29_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-73 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.732440454733934 none INSR_1_111101111 Context-specific genetic dependencies (73) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT55_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-74 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.270073824778631 none INSR_1_111101111 Context-specific genetic dependencies (74) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HUG1N_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-75 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.83802946802322 none INSR_1_111101111 Context-specific genetic dependencies (75) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HUTU80_SMALL_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-76 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.167870013830123 none INSR_1_111101111 Context-specific genetic dependencies (76) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IGR39_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-77 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.205377107052478 none INSR_1_111101111 Context-specific genetic dependencies (77) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IGROV1_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-78 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.574457150763316 none INSR_1_111101111 Context-specific genetic dependencies (78) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IOMMLEE_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-79 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.590904537581076 none INSR_1_111101111 Context-specific genetic dependencies (79) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHESOAD1_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-8 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.238135575593255 none INSR_1_111101111 Context-specific genetic dependencies (8) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A549_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-80 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.12785357766367 none INSR_1_111101111 Context-specific genetic dependencies (80) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHOC5_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-81 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.559053065663124 none INSR_1_111101111 Context-specific genetic dependencies (81) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHOM1_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-82 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.126808067384726 none INSR_1_111101111 Context-specific genetic dependencies (82) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-83 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.285881101325879 none INSR_1_111101111 Context-specific genetic dependencies (83) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-84 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.348265967848108 none INSR_1_111101111 Context-specific genetic dependencies (84) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KALS1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-85 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 2.00973386692556 Increased shRNA abundance (Z-score > 2) INSR_1_111101111 Context-specific genetic dependencies (85) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-86 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.822606931535354 none INSR_1_111101111 Context-specific genetic dependencies (86) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KM12_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-87 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.385875124593512 none INSR_1_111101111 Context-specific genetic dependencies (87) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-88 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.494712475568619 none INSR_1_111101111 Context-specific genetic dependencies (88) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KNS60_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-89 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.125023270830417 none INSR_1_111101111 Context-specific genetic dependencies (89) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KNS81_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-9 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.28266680356048 none INSR_1_111101111 Context-specific genetic dependencies (9) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A673_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-90 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0973041236164727 none INSR_1_111101111 Context-specific genetic dependencies (90) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP1NL_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-91 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.817816034593533 none INSR_1_111101111 Context-specific genetic dependencies (91) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP2_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-92 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.128570499596969 none INSR_1_111101111 Context-specific genetic dependencies (92) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP4_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-93 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.043429331465938 none INSR_1_111101111 Context-specific genetic dependencies (93) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KURAMOCHI_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-94 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.304852089054549 none INSR_1_111101111 Context-specific genetic dependencies (94) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE150_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-95 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0375238395736296 none INSR_1_111101111 Context-specific genetic dependencies (95) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE30_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-96 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.0479644888513214 none INSR_1_111101111 Context-specific genetic dependencies (96) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE450_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-97 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 0.132804242892818 none INSR_1_111101111 Context-specific genetic dependencies (97) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE510_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-98 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.0616715421668204 none INSR_1_111101111 Context-specific genetic dependencies (98) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line L33_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-99 3643 INSR TRCN0000000379, TRCN0000000380, TRCN0000000381, TRCN0000000382, TRCN0000039698, TRCN0000039699, TRCN0000039700, TRCN0000039701 -0.23406808198206 none INSR_1_111101111 Context-specific genetic dependencies (99) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
3643 3643 INSR -0.11000000000000001 none
GR00371-A-1 3643 3643 INSR 0.755516345005 none Dharmacon Nanog expression in absence of bFGF and TGFbeta Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-2 3643 INSR 3643 0.80439482972 none Dharmacon Nanog expression in presence of TGFbeta inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-3 3643 3643 INSR 1.05140408681 none Dharmacon Nanog expression in presence of MEK inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-4 3643 3643 INSR 1.02284587629 none Dharmacon Nanog expression in presence of PI3K inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-5 3643 3643 INSR -0.185406024495 none Dharmacon Nanog expression in presence of retinoic acid Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00376-A-1 3643 3643 INSR 0.046449518 none Mitigators of SS1P-induced immunotoxicity Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity Pasetto et al. 2015 25713356 Cell line KB cells Viability Luminescence Ambion Silencer Select Version 4 Genome-wide siRNA RSA P-value <0.001 SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID
GR00376-A-2 3643 3643 INSR 0.423947641 none Sensitizers of SS1P-induced immunotoxicity Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity Pasetto et al. 2015 25713356 Cell line KB cells Viability Luminescence Ambion Silencer Select Version 4 Genome-wide siRNA RSA P-value <0.001 SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID
GR00378-A 3643 INSR -0.661625149 none Poliovirus vaccine production Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game van der Sanden et al. 2015 26581994 Cell line HEp-2C Infection with Attenuated Poliovirus ELISA Dharmacon Genome-wide siRNA Z-score > For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol
3643 NM_000208 INSR 31.613 none
GR00386-A-1 3643 3643 INSR 103.766994762269 none NOD2 stimulation by MDP A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. Warner et al. 2014 25170077 Cell line HEK293 stably expressing NOD2 Viability Luminescence Dharmacon Genome-wide siRNA Percentage growth Decreased: <70, increased: >120 Reagent IDs not provided
GR00386-A-2 3643 3643 INSR -21.9 none MDP-induced IL-8 secretion A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. Warner et al. 2014 25170077 Cell line HEK293 stably expressing NOD2 IL-8 secretion ELISA Dharmacon Genome-wide siRNA Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided