RNAi

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 5590
• Symbol: PRKCZ
• Description: protein kinase C zeta

DataSource: http://genomernai.dkfz.de/v16/genedetails/5590

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Stable_ID	Entrez_ID	Gene_ID	Gene_Symbol	Reagent_ID	Score	Phenotype	Conditions	Follow_Up	Comment	Screen_Title	Publication_Title	Authors	Publication_Year	Pubmed_ID	Biosource	Biomodel	Assay	Method	Library	Scope	Reagent_Type	Score_Type	Cutoff	Notes
GR00016-A	5590	5590	PRKCZ	np	1.35	none		no		Wnt/beta-catenin pathway regulation	Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.	James et al.	2009	19471023	Cell line	RKO	Wnt/beta-catenin pathway reporter	Luminescence	rp	Selected genes	siRNA	Z-score	> 2
GR00053-A	5590	NM_002744	PRKCZ	np	sp	none		no		Genome stability	A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.	Paulsen et al.	2009	19647519	Cell line	HeLa	gamma-H2AX phosphorylation and DNA content	Fluorescence	siARRAY human genome siRNA library	Genome-wide	siRNA	p-value	Complex criteria	Confidence groupings from 4 to 1 (highest level of confidence in group 4)
GR00054-A	5590	NM_002744	PRKCZ	np	0.89	none		no		Combinatorial effect with paclitaxel	Synthetic lethal screen identification of chemosensitizer loci in cancer cells.	Whitehurst et al.	2007	17429401	Cell line	NCI-H1155	Viability (synthetic lethal)	ATP level	# G-005000-01	Genome-wide	siRNA	Paclitaxel/control ratio	Complex criteria	Additional information about 87 high-confidence hits
	5590	5590	PRKCZ	np	np	Decreased cell migration		yes	deconvoluted validated siRNAs: 2/4
GR00055-A-3	5590	5590	PRKCZ	np	np	none		no		Epithelial cell migration (3)	Identification of genes that regulate epithelial cell migration using an siRNA screening approach.	Simpson et al.	2008	19160483	Cell line	MCF-10A overexpressing ERBB2	Cell migration and viability	Microscopy and fluorescence	SMARTpool siRNA library and MAR library	Selected genes	siRNA	Area score and Alamar score	Complex criteria
GR00056-A	5590	NM_002744	PRKCZ	np	0.92	none		no		Melanogenesis	Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.	Ganesan et al.	2008	19057677	Cell line	MNT-1	Melanin protein expression and viability	Absorbance and luminescence	rp	Genome-wide	siRNA	Normalized absorbance ratio	> 2 standard deviations below mean	Additional information about a secondary screen (retest to determine false-positive rate)
GR00057-A-1	5590	NM_002744	PRKCZ	M-003526-02	-0.55	none		no		Wnt/beta-catenin pathway regulation (1)	A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer.	Tang et al.	2008	18621708	Cell line	HeLa	Wnt pathway reporter	Luminescence	Human siArray siRNA library	Genome-wide	siRNA	Z-score	> 4	Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00057-A-2	5590	NM_002744	PRKCZ	M-003526-02	sp	none		no		Wnt/beta-catenin pathway regulation (2)	A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer.	Tang et al.	2008	18621708	Cell line	HeLa	Wnt pathway reporter	Luminescence	Human siArray siRNA library	Genome-wide	siRNA	Complex, SP	Complex criteria	Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00095-A	5590	NM_002744	PRKCZ	np	np	none				p53 pathway components	A large-scale RNAi screen in human cells identifies new components of the p53 pathway	Berns et al.	2004	15042092	Cell line	BJ-TERT-tsLT fibroblasts	Proliferation	Colony-forming cell assay	Nki library	Genome-wide	shRNA	np	np
GR00098-A-1	5590	ENSG00000067606	PRKCZ	ENSG00000067606	sp	none		no		Cell division (1)	Genome-scale RNAi profiling of cell division in human tissue culture cells.	Kittler et al.	2007	17994010	Cell line	HeLa	Cell number and DNA content	Laser scanning cytometry	rp	Genome-wide	esiRNA	Complex, sp	Complex criteria
GR00103-A-0	5590		PRKCZ	v2HS_170475	-1.02	Increased cell death HMECs cells		no		Cell viability	Cancer proliferation gene discovery through functional genomics.	Schlabach et al.	2008	18239126	Cell line	DLD-1, HCT116; HCC1954; HMECs (mammary epithelia cells)	Cell viability	Micoarray hybridization	shRNA-mir (G. Hannon)		shRNA	log ratio	<
GR00114-A	5590		PRKCZ	np	-0.72	none			88%	Combinatorial effect with Poly (ADP‐ribose)‐polymerase‐1 (PARP)	A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.	Turner et al.	2008	18388863	Cell line	CAL51	Viability	Luminescence	siARRAY SMARTpool	Kinases	siRNA	Z-score	<	Growth rates (%) for vehicle-alone experiments are given in the comment field.
GR00120-A	5590		PRKCZ	np	-7.18	Increased viability with tamoxifen				Tamoxifen sensitization	Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization	Iorns et al.	2009	18976239	Cell line	MCF-7	Viability	Luminescence	SMARTpool kinase library, Dharmacon	Kinases	siRNA	Z-score	<
GR00123-A	5590	NM_002744	PRKCZ	100593, 100591, 100592	np	none				Combinatorial effect with nutlin-3	An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors	Brummelkamp et al.	2006	16474381	Cell line	MCF-7	Viability	Fluoresence	Nki library	Genome-wide	shRNA	log2 ratio	np
GR00133-A-1	5590	5590	PRKCZ	np	0.284003	none		no		Salmonella enterica subspecies 1 serovar Typhimurium invasion (1)	RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42.	Misselwitz et al.	2011	21407211	Cell line	HeLa	Gentamycin protection invasion assay	Fluorescence	Druggable genome library V2.0	Druggable genes	siRNA	log2 median	Complex criteria
GR00143-A	5590		PRKCZ	PRKCZ s1	sp	none		no		tau phosphorylation	High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.	Azorsa et al.	2010	20067632	Cell line	H4 overexpressing 4RON tau	Total tau and 12E8 tau protein expression	Fluorescence	Validated human kinase siRNA Set 2.0	Kinases	siRNA	p-value	Complex criteria
GR00143-A	5590		PRKCZ	PRKCZ s2	sp	none		no		tau phosphorylation	High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.	Azorsa et al.	2010	20067632	Cell line	H4 overexpressing 4RON tau	Total tau and 12E8 tau protein expression	Fluorescence	Validated human kinase siRNA Set 2.0	Kinases	siRNA	p-value	Complex criteria
GR00149-A-1	5590	5590	PRKCZ	103629	-31.49	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	5590	5590	PRKCZ	103679	65.65	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	5590	5590	PRKCZ	103679	85.55	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	5590	5590	PRKCZ	142298	-33.77	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	5590	5590	PRKCZ	142298	-4.21	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	5590	5590	PRKCZ	103575	70.78	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	5590	5590	PRKCZ	103575	59.23	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00149-A-1	5590	5590	PRKCZ	103629	-49.45	none		no		Ciliogenesis and cilium length (1)	Functional genomic screen for modulators of ciliogenesis and cilium length.	Kim et al.	2010	20393563	Cell line	htRPE	Smoothed protein expression	Fluorescence	Human druggable genome siRNA library V3.1	Druggable genes	siRNA	Normalized percent inhibition	> 1.5 OR < -1.5 standard deviations from mean
GR00151-A-1	5590	ENSG00000067606	PRKCZ	np	0.094	none		no		Homologous recombination DNA double-strand break repair (HR-DSBR) (1)	A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.	SÅ‚abicki et al.	2010	20613862	Cell line	HeLa	(HR-DSBR) DR-GFP reporter	Flow cytometry	Custom-made	Genome-wide	esiRNA	Z-score	< -2 OR > 2
GR00155-A	5590	5590	PRKCZ	PRKCZ_1, PRKCZ_2, PRKCZ_3	np	none		no		Aryl hydrocarbon receptor (AhR) transduction pathway regulation	RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity.	Gilot et al.	2011	21479225	Cell line	MCF-7	TCDD-induced CYP1A1-related EROD activity and cell viability	Fluorescence and methylene blue	MISSION siRNA Human Kinase Panel library	Kinases	siRNA	Z-score	Top 150 for >
GR00180-A-1	5590	5590	PRKCZ	PL-50002	0.926	none		no		Hepatitis C virus replication (1)	A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.	Tai et al.	2009	19286138	Cell line	Huh7/Rep-Feo	HCV replicon RNA copy number	Luminescence	siARRAY Human Genome siRNA Library	Genome-wide	siRNA	q-value	Complex criteria
GR00184-A-1	5590	NM_002744	PRKCZ	M-003526-04	0.150600904632207	none		no		Self-renewal and pluripotency in human embryonic stem cells (1)	A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.	Chia et al.	2010	20953172	Cell line	hESC H1	POU5F1 protein expression	Fluorescence	SMARTpool siRNA library	Genome-wide	siRNA	Z-score	< -2
GR00193-A-1	5590	5590	PRKCZ	PRKCZ	0.567305026744773	none		yes		Therapeutic kinase targets in neuroblastoma (1)	RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma.	Cole et al.	2011	21289283	Cell line	EBC1	Substrate adherent cell growth	rp	Kinase siGenome library	Kinases	siRNA	Relative growth	0.5 standard deviations below mean
GR00193-A-2	5590	5590	PRKCZ	PRKCZ	0.746	none		yes		Therapeutic kinase targets in neuroblastoma (2)	RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma.	Cole et al.	2011	21289283	Cell line	KELLY	Substrate adherent cell growth	rp	Kinase siGenome library	Kinases	siRNA	Relative growth	0.5 standard deviations below mean
GR00193-A-3	5590	5590	PRKCZ	PRKCZ	0.913217717346558	none		yes		Therapeutic kinase targets in neuroblastoma (3)	RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma.	Cole et al.	2011	21289283	Cell line	SKNAS	Substrate adherent cell growth	rp	Kinase siGenome library	Kinases	siRNA	Relative growth	0.5 standard deviations below mean
GR00193-A-4	5590	5590	PRKCZ	PRKCZ	0.774	none		no		Therapeutic kinase targets in neuroblastoma (4)	RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma.	Cole et al.	2011	21289283	Cell line	NLF	Substrate adherent cell growth	rp	Kinase siGenome library	Kinases	siRNA	Relative growth	0.5 standard deviations below mean
GR00196-A-1	5590	ENSG00000067606		np	sp	none		no		TP53 interactions (1)	A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly.	Krastev et al.	2011	21642980	Cell line	HCT116 ( wildtype and TP53 knockout)	TP53 protein expression and viability	Fluorescence	rp	Genome-wide	esiRNA	Complex, sp	Complex criteria
GR00197-A-1	5590	5590	PRKCZ	M-003526-02	-0.533851358	none		no		Human papillomavirus oncogene expression regulation (1)	Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression.	Smith et al.	2010	20133580	Cell line	C33A/BE2/18LCR c4	HPV18 LCR reporter activity	Luminescence	Human siGENOME SMARTpool library	Genome-wide	siRNA	Z-score	>	Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5
GR00206-A	5590	5590	PRKCZ	np	np	none		no		Apoptosis regulation after Chlamydia trachomatis serovar L2 infection	HIF-1α is involved in mediating apoptosis resistance to Chlamydia trachomatis-infected cells.	Sharma et al.	2011	21824245	Cell line	HeLa	Cleaved cytokeratin-18 protein expression	Fluorescence	Custom-made	Apoptosis, cellular trafficking and cell signalling genes	siRNA	p-value	<	Author-reviewed data
GR00210-A	5590	5590	PRKCZ	np	sp	none		no		Focal adhesion formation	Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown.	Winograd-Katz et al.	2009	19667130	Cell line	HeLa	paxillin protein expression	Fluorescence	SMARTpool siARRAY siRNA Libraries	Kinases, phosphatases and selected genes	siRNA	Z-score	> 3.5 OR < -3.5
GR00221-A-1	5590		PRKCZ	TRCN0000010121	-3.16	Decreased viability		yes		Proliferation of cells with active beta-catenin (1)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MCF-7	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-1	5590		PRKCZ	TRCN0000010114	-0.53	none		yes		Proliferation of cells with active beta-catenin (1)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MCF-7	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-1	5590		PRKCZ	TRCN0000010112	0.34	none		yes		Proliferation of cells with active beta-catenin (1)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MCF-7	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-1	5590		PRKCZ	TRCN0000010113	0.79	none		yes		Proliferation of cells with active beta-catenin (1)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MCF-7	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-1	5590		PRKCZ	TRCN0000010120	0.85	none		yes		Proliferation of cells with active beta-catenin (1)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MCF-7	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-2	5590		PRKCZ	TRCN0000010121	-2.23	Decreased viability		yes		Proliferation of cells with active beta-catenin (2)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-231	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-2	5590		PRKCZ	TRCN0000010114	-0.03	none		yes		Proliferation of cells with active beta-catenin (2)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-231	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-2	5590		PRKCZ	TRCN0000010113	0.1	none		yes		Proliferation of cells with active beta-catenin (2)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-231	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-2	5590		PRKCZ	TRCN0000010112	0.43	none		yes		Proliferation of cells with active beta-catenin (2)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-231	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-3	5590		PRKCZ	TRCN0000010114	0.18	none		yes		Proliferation of cells with active beta-catenin (3)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-453	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-3	5590		PRKCZ	TRCN0000010112	0.66	none		yes		Proliferation of cells with active beta-catenin (3)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-453	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-3	5590		PRKCZ	TRCN0000010113	1.12	none		yes		Proliferation of cells with active beta-catenin (3)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-453	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-3	5590		PRKCZ	TRCN0000010121	4.16	none		yes		Proliferation of cells with active beta-catenin (3)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	MDA-MB-453	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-4	5590		PRKCZ	TRCN0000010112	-0.93	none		no		Proliferation of cells with active beta-catenin (4)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	T47D	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-4	5590		PRKCZ	TRCN0000010120	-0.21	none		no		Proliferation of cells with active beta-catenin (4)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	T47D	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-4	5590		PRKCZ	TRCN0000010121	0.91	none		no		Proliferation of cells with active beta-catenin (4)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	T47D	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-4	5590		PRKCZ	TRCN0000010113	0.99	none		no		Proliferation of cells with active beta-catenin (4)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	T47D	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00221-A-4	5590		PRKCZ	TRCN0000010114	1.44	none		no		Proliferation of cells with active beta-catenin (4)	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	Kim et al.	2010	20126544	Cell line	T47D	Viability	Luminescence	TRC shRNA Library	Kinases	shRNA	B-score	< -1	Essential gene: gene with B-score < -1 for >
GR00225-A	5590		PRKCZ	PRKCZ_A	-0.108535	none	5nM gemcitabine	no		Combinatorial effect with gemcitabine	Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.	Azorsa et al.	2009	19519883	Cell line	MIAPaCa-2	Viability (synthetic lethal)	Luminescence	Validated kinase siRNA library version 1.0	Kinases	siRNA	log2 ratio	1.65 SD below mean ratio level
GR00225-A	5590		PRKCZ	PRKCZ_B	-0.088157	none	5nM gemcitabine	no		Combinatorial effect with gemcitabine	Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.	Azorsa et al.	2009	19519883	Cell line	MIAPaCa-2	Viability (synthetic lethal)	Luminescence	Validated kinase siRNA library version 1.0	Kinases	siRNA	log2 ratio	1.65 SD below mean ratio level
GR00225-A	5590		PRKCZ	PRKCZ_A	-0.821629	none	10nM gemcitabine	no		Combinatorial effect with gemcitabine	Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.	Azorsa et al.	2009	19519883	Cell line	MIAPaCa-2	Viability (synthetic lethal)	Luminescence	Validated kinase siRNA library version 1.0	Kinases	siRNA	log2 ratio	1.65 SD below mean ratio level
GR00225-A	5590		PRKCZ	PRKCZ_B	-1.029971	none	10nM gemcitabine	no		Combinatorial effect with gemcitabine	Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.	Azorsa et al.	2009	19519883	Cell line	MIAPaCa-2	Viability (synthetic lethal)	Luminescence	Validated kinase siRNA library version 1.0	Kinases	siRNA	log2 ratio	1.65 SD below mean ratio level
	5590	NM00103358	PRKCZ	np	0.982172	none		no
GR00231-A	5590	NM_002744	PRKCZ	M-003526-02	0.789	none		yes		Cell proliferation	Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation.	Zhang et al.	2011	21765947	Cell line	HeLa	Viability	Electrical impedance	Human siARRAY - Protein Kinase and Cell Cycle libraries	Kinases and selected genes	siRNA	Z-score	< -1.96 OR > 1.96	Additional information about cell titer blue cell viability screen
GR00234-A-1	5590	NM_002744	PRKCZ	np	sp	Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection		yes		Hepatitis C virus (HCV) infection (1)	EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.	Lupberger et al.	2011	21516087	Cell line	Huh7	Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) protein expression	Luminescence	Human Kinase RNAi Set V2.0	Kinases	siRNA	Complex, sp	Complex criteria
GR00234-A-2	5590	NM_002744	PRKCZ	np	sp	Decreased cell–culture–derived Hepatitis C virus (HCVcc; Luc–Jc1) infection		yes	2 of 4 siRNAs validated	Hepatitis C virus (HCV) infection (2)	EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.	Lupberger et al.	2011	21516087	Cell line	Huh7.5.1	Cell–culture–derived Hepatitis C virus (HCVcc; Luc–Jc1) and vesicular stomatitis virus pseudoparticles (VSVpp) protein expression	Luminescence	np	Kinases	siRNA	Complex, sp	Complex criteria
GR00236-A-1	5590	5590	PRKCZ	M-003526-02	0.841240844413227	none		no		Homologous recombination DNA double-strand break repair (HR-DSBR) (1)	A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.	Adamson et al.	2012	22344029	Cell line	DR-U2OS	(HR-DSBR) DR-GFP reporter and DNA content	Fluorescence	Human siGENOME siRNA (G-005000-05)	Genome-wide	siRNA	Relative HR ratio	< ~0.4 OR > 1.88	Cutoff values correspond 2 standard deviations from the screen-wide mean
GR00240-S-1	5590	NM_002744	PRKCZ	M-003526-02	-0.95	none		yes		TRAIL-induced apoptosis (1)	A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis.	Kranz and Boutros	2014	24442637	Cell line	U251MG	Viability	Luminescence	SMART-pool siRNA	Genome-wide	siRNA	Z-score	> 4	Author-submitted data
GR00240-S-2	5590	NM_002744	PRKCZ	M-003526-02	0.36	none		no	Z-score -0.5795	TRAIL-induced apoptosis (2)	A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis.	Kranz and Boutros	2014	24442637	Cell line	U251MG	Viability (synthetic lethal)	Luminescence	SMART-pool siRNA	Genome-wide	siRNA	Differential score	> 3.6 AND viability Z-score < 4	Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen.
GR00242-A-1	5590	NM_002744	PRKCZ	np	sp	none		no		Selective autophagy regulation (1)	Image-based genome-wide siRNA screen identifies selective autophagy factors.	Orvedahl et al.	2011	22020285	Cell line	HeLa/GFP-LC3	Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression	Fluorescence	siGenome	Genome-wide	siRNA	Z-score	Complex criteria
GR00243-A	5590	5590	PRKCZ	103629, 103679, 242362	np	none		no		Cdk9 T-loop phosphorylation	Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway.	Ramakrishnan and Rice	2012	21448926	Cell line	HeLa	Cdk9 T-loop phosphorylation and beta-Actin protein expression	Fluorescence	np	Kinases	siRNA	np	>
GR00247-A-1	5590		PRKCZ	np	sp	none			rank: 17044	Regulation of FOXO1 nuclear localization (1)	Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain.	Senapedis et al.	2011	21460183	Cell line	U2OS	EGFP-FOXO1a protein expression and DNA content	Fluorescence	Human Genome library	Genome-wide	siRNA	Complex, sp	Complex criteria
GR00248-A	5590	NM_002744	PRKCZ	PRKCZ_siRNA1	2.495	Increased human cytomegalovirus (HCMV) strain AD169 replication				Human cytomegalovirus (HCMV) strain AD169 replication	Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.	Terry et al.	2012	22315427	Cell line	MRC5	Human cytomegalovirus (HCMV) IE1 protein expression	Fluorescence	Mission siRNA Human Kinase Panel	Kinases	siRNA	Z-score	>
GR00248-A	5590	NM_002744	PRKCZ	PRKCZ_siRNA2	-1.182	none				Human cytomegalovirus (HCMV) strain AD169 replication	Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.	Terry et al.	2012	22315427	Cell line	MRC5	Human cytomegalovirus (HCMV) IE1 protein expression	Fluorescence	Mission siRNA Human Kinase Panel	Kinases	siRNA	Z-score	>
GR00248-A	5590	NM_002744	PRKCZ	PRKCZ_siRNA3	0.071	none				Human cytomegalovirus (HCMV) strain AD169 replication	Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.	Terry et al.	2012	22315427	Cell line	MRC5	Human cytomegalovirus (HCMV) IE1 protein expression	Fluorescence	Mission siRNA Human Kinase Panel	Kinases	siRNA	Z-score	>
GR00249-S	5590	5590	PRKCZ	J-003526-14	1.12318	Increased vaccinia virus (VACV) infection		no	number of cells compared to control (%): 70.29	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	5590	5590	PRKCZ	M-003526-04	-0.5937	none		no	number of cells compared to control (%): 77.87	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	5590	5590	PRKCZ	s11128	0.70282	none		no	number of cells compared to control (%): 83.03	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	5590	5590	PRKCZ	s11129	0.19016	none		no	number of cells compared to control (%): 99.54	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S	5590	5590	PRKCZ	s11130	0.01341	none		no	number of cells compared to control (%): 86.76	Vaccinia virus (VACV) infection	Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.	Sivan et al.	2013	23401514	Cell line	HeLa	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	Fluorescence	Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus	Genome-wide	siRNA	Z-score	>	Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00250-A-1	5590	5590	PRKCZ	M-003526-02	sp	Synthetic lethal with MLN4924 (a NAE inhibitor)			duplicate screen	Combinatorial effect with MLN4924, a NAE inhibitor (1)	Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.	Blank et al.	2013	23100467	Cell line	A375	Viability (synthetic lethal)	Luminescence	np	Genome-wide	siRNA	Complex, sp	Complex criteria	Phenotypes for 650 nmol/L MLN4924. Additional information about screens with 250 nmol/L MLN4924.
GR00250-A-2	5590	5590	PRKCZ	D-003526-10	sp	Increased viability with MLN4924 (a NAE inhibitor)			sextuplicate screen	Combinatorial effect with MLN4924, a NAE inhibitor (2)	Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.	Blank et al.	2013	23100467	Cell line	A375	Viability (synthetic lethal)	Luminescence	np	Selected genes	siRNA	Complex, sp	Complex criteria	Phenotypes for 650 nmol/L MLN4924. Additional information about screens with 250 nmol/L MLN4924.
GR00250-A-2	5590	5590	PRKCZ	D-003526-11	sp	Synthetic lethal with MLN4924 (a NAE inhibitor)			sextuplicate screen	Combinatorial effect with MLN4924, a NAE inhibitor (2)	Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.	Blank et al.	2013	23100467	Cell line	A375	Viability (synthetic lethal)	Luminescence	np	Selected genes	siRNA	Complex, sp	Complex criteria	Phenotypes for 650 nmol/L MLN4924. Additional information about screens with 250 nmol/L MLN4924.
GR00250-A-2	5590	5590	PRKCZ	D-003526-12	sp	Increased viability with MLN4924 (a NAE inhibitor)			sextuplicate screen	Combinatorial effect with MLN4924, a NAE inhibitor (2)	Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.	Blank et al.	2013	23100467	Cell line	A375	Viability (synthetic lethal)	Luminescence	np	Selected genes	siRNA	Complex, sp	Complex criteria	Phenotypes for 650 nmol/L MLN4924. Additional information about screens with 250 nmol/L MLN4924.
GR00250-A-2	5590	5590	PRKCZ	D-003526-13	sp	Synthetic lethal with MLN4924 (a NAE inhibitor)			sextuplicate screen	Combinatorial effect with MLN4924, a NAE inhibitor (2)	Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.	Blank et al.	2013	23100467	Cell line	A375	Viability (synthetic lethal)	Luminescence	np	Selected genes	siRNA	Complex, sp	Complex criteria	Phenotypes for 650 nmol/L MLN4924. Additional information about screens with 250 nmol/L MLN4924.
GR00253-A	5590	NM_002744	PRKCZ	np	-0.147	none				hepcidin regulation	Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.	Mleczko-Sanecka et al.	2014	24385536	Cell line	Huh7	hepcidin::fluc mRNA expression	Luminescence	siGenome siARRAY SMARTpool	Genome-wide	siRNA	Z-score	>	Cutoff <
GR00255-A-1	5590	5590	PRKCZ	TRCN0000001218, TRCN0000001219, TRCN0000001220, TRCN0000001221, TRCN0000001222, TRCN0000010112, TRCN0000010113, TRCN0000010114, TRCN0000010120, TRCN0000010121	0.0471454	none				Negative genetic interactions (1)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -1.0	HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-2	5590	5590	PRKCZ	TRCN0000001218, TRCN0000001219, TRCN0000001220, TRCN0000001221, TRCN0000001222, TRCN0000010112, TRCN0000010113, TRCN0000010114, TRCN0000010120, TRCN0000010121	-0.448672122	none				Negative genetic interactions (2)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -1.0	HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-3	5590	5590	PRKCZ	TRCN0000001218, TRCN0000001219, TRCN0000001220, TRCN0000001221, TRCN0000001222, TRCN0000010112, TRCN0000010113, TRCN0000010114, TRCN0000010120, TRCN0000010121	-0.75837904	none				Negative genetic interactions (3)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -1.2	HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-4	5590	5590	PRKCZ	TRCN0000001218, TRCN0000001219, TRCN0000001220, TRCN0000001221, TRCN0000001222, TRCN0000010112, TRCN0000010113, TRCN0000010114, TRCN0000010120, TRCN0000010121	-1.29219902	Negative genetic interaction between PTTG1-/- and PTTG1+/+				Negative genetic interactions (4)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -1.2	HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-5	5590	5590	PRKCZ	TRCN0000001218, TRCN0000001219, TRCN0000001220, TRCN0000001221, TRCN0000001222, TRCN0000010112, TRCN0000010113, TRCN0000010114, TRCN0000010120, TRCN0000010121	0.787814055	none				Negative genetic interactions (5)	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	Vizeacoumar et al.	2013	24104479	Cell line	HCT116	shRNA abundance	Microarray	np	Genome-wide	shRNA	differential Gene Activity Ranking Profile (dGARP)	< -0.8	HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00256-A	5590	NM_002744, NM_001033581, NM_001033582	PRKCSH	np	sp	none				Kinase-mediated spindle orientation	ABL1 regulates spindle orientation in adherent cells and mammalian skin.	Matsumara et al.	2012	22252550	Cell line	HeLa	beta-tubulin protein expression and DNA content	Fluorescence	Silencer Kinase siRNA library (AM80010V3)	Kinases	siRNA	Complex, sp	Complex criteria	HeLa cells stably expressing GFP-H2B (HeLa-GH2B) used. Additional information about secondary screens.
GR00293-A	5590		PRKCZ	np	-1.06	none				Combinatorial effect with paclitaxel	Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death	Sinnott et al.	2014	24860162	Cell line	HCC366	Viability	Luminescence	Thermo-Fisher	Genome-wide	siRNA	Z-score	< -2.5	Final hits according to the author are indicated in the comment.
GR00300-A	5590		PRKCZ	TRCN0000010114, TRCN0000001222, TRCN0000010113, TRCN0000001221, TRCN0000010112, TRCN0000001220, TRCN0000010120, TRCN0000010121, TRCN0000199050, TRCN0000195238, TRCN0000199469, TRCN0000204881, TRCN0000001218, TRCN0000199679, TRCN0000001219	1	none				Combinatorial effect with RAF inhibitor PLX4720	A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.	Whittaker et al.	2013	23288408	Cell line	A375	shRNA abundance	Sequencing	TRC	Genome-wide	shRNA	Number of shRNAs ranked Top1000	> 2	The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors.
GR00303-A	5590	NM_002744	PRKCZ	np	-0.38	none				Clear cell renal cell carcinoma (ccRCC) survival regulation	Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target	Gerlinger et al.	2012	22362593	Cell line	VHL-deficient RCC4	Proliferation and Viability	Fluorescence	np	Genome-wide	siRNA	Z-score	<	In the phenotype data duplicates were in the original document, which have been removed.
GR00310-A-1	5590	5590	PRKCZ	np	-0.42	none				Sindbis virus (SINV) infection (1)	Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry	Ooi et al.	2013	24367265	Cell line	U2OS	Sindbis virus (SINV) reporter	Luminescence	Ambion Silencer V3	Genome-wide	siRNA	Z-score	< -3 OR > 2
	5590	5590	PRKCZ	np	42.1	none			108,6% viability
GR00313-A	5590	NM_001033581, NM_001033582, NM_002744	PRKCZ	np	0.91	none				TNF-alpha pathway regulation	A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling.	Nickles et al.	2012	22733992	Cell line	HEK293T	NFkappaB pathway reporter	Luminescence	Qiagen	Genome-wide	siRNA	Z-score	<	Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%.
GR00318-A	5590	5590	PRKCZ	np	0.877	none			siRNA set: kinase	Huntingtin toxicity	A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease	Miller et al.	2012	23209424	Cell line	HEK293T	Caspase 3/7 activity	Fluorescence	Dharmacon	Selected genes	siRNA	Sum of normalized caspase 3/7 activity mean and standard error	< 0.683	HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP).
GR00342-S-1	5590		PRKCZ	M-003526-04	-1.3152056887202526	none				Viability of Mesenchymal Stem Cells (MSC) (1)	Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening	Erdmann et al.	2015	26120366	Primary cells	Bone marrow derived MSC	Viability	Luminescence	Kinase siGENOME SMARTpool library	Kinases and phosphatases	siRNA	Z-score	>	Donor 1, MSC preparation 1 (MSC1a)
GR00342-S-2	5590		PRKCZ	M-003526-04	-2.4105410563318883	Decreased viability				Viability of Mesenchymal Stem Cells (MSC) (2)	Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening	Erdmann et al.	2015	26120366	Primary cells	Bone marrow derived MSC	Viability	Luminescence	Kinase siGENOME SMARTpool library	Kinases and phosphatases	siRNA	Z-score	>	Donor 1, MSC preparation 2 (MSC1b)
GR00342-S-3	5590		PRKCZ	M-003526-04	-2.135935915326002	Decreased viability				Viability of Mesenchymal Stem Cells (MSC) (3)	Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening	Erdmann et al.	2015	26120366	Primary cells	Bone marrow derived MSC	Viability	Luminescence	Kinase siGENOME SMARTpool library	Kinases and phosphatases	siRNA	Z-score	>	Donor 2, MSC preparation 1 (MSC2)
GR00343-S	5590	5590	PRKCZ	TRCN0000010113	1.1199999999999992	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	5590	5590	PRKCZ	TRCN0000010120	-1.4124999999999996	shRNA abundance <= 50%				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	5590	5590	PRKCZ	TRCN0000010114	0.9375	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	5590	5590	PRKCZ	TRCN0000010121	0.33999999999999986	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	5590	5590	PRKCZ	TRCN0000010112	1.084999999999999	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	5590	5590	PRKCZ	TRCN0000001220	0.5949999999999989	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	5590	5590	PRKCZ	TRCN0000001221	-0.8650000000000002	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	5590	5590	PRKCZ	TRCN0000001219	-0.21749999999999936	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	5590	5590	PRKCZ	TRCN0000001218	0.5449999999999999	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00343-S	5590	5590	PRKCZ	TRCN0000001222	1.0725000000000016	none				Lentiviral shRNA "Achilles Heel" screen	Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia	Cole et al.	2015	26058080	Cell line	K562	shRNA abundance	Fluorescence	Lentiviral shRNA library	Genome-wide	shRNA	Log2 ratio	<	Comparison of day 21 vs. day 0 abundance data
GR00355-A	5590	5590	PRKCZ	np	1.784180803	Increased epidermal growth factor receptor (EGFR) surface abundance				PIP3-mediated epidermal growth factor (EGFR) endocytosis	PIP3 induces the recycling of receptor tyrosine kinases	Laketa et al.	2014	24425787	Cell line	HeLa Kyoto	Epidermal growth factor (EGFR) surface abundance	Fluorescence	Qiagen	Selected genes	siRNA	Deviation score	< -1 OR > 1	HeLa Kyoto cells were stably transfected with EGFR-EYFP. Reagent Sequences (but no reagent ID) available in Table S4.
GR00356-A-1	5590	NM_002744	PRKCZ	np	0.48	none				Clathrin-mediated endocytosis	Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis.	Pelkmans et al.	2005	15889048	Cell line	HeLa	Vesicular stomatitis virus (VSV) infection (rVSV–GFP expression)	Fluorescence	Ambion	Kinases	siRNA	Relative infection index (RII)	<	The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Caveolin- and lipid raft-mediated endocytosis" using simian virus 40 (SV40).
GR00356-A-2	5590	NM_002744	PRKCZ	np	3.248079162997862	Increased simian virus 40 (SV40) infection				Caveolin- and lipid raft-mediated endocytosis	Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis.	Pelkmans et al.	2005	15889048	Cell line	HeLa	Simian virus 40 (SV40) infection (SV40 large T-antigen expression)	Fluorescence	Ambion	Kinases	siRNA	Relative infection index (RII)	<	The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Clathrin-mediated endocytosis" using vesicular stomatitis virus (VSV).
GR00356-A-3	5590	NM_002744	PRKCZ	np	np	none				Endocytosis regulation	Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis.	Pelkmans et al.	2005	15889048	Cell line	HeLa	Transferrin (Tfn) uptake and trafficking	Fluorescence	Ambion	Kinases	siRNA	np	np
GR00366-A-1	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.547925781289511	none			PRKCZ_1_00111001	Context-specific genetic dependencies (1)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	22RV1_PROSTATE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-10	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.00928818651752203	none			PRKCZ_1_00111001	Context-specific genetic dependencies (10)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	ACHN_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-100	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.786490347237332	none			PRKCZ_1_00111001	Context-specific genetic dependencies (100)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-101	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.859438997233663	none			PRKCZ_1_00111001	Context-specific genetic dependencies (101)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LK2_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-102	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.326961022792708	none			PRKCZ_1_00111001	Context-specific genetic dependencies (102)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN215_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-103	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.378133632670503	none			PRKCZ_1_00111001	Context-specific genetic dependencies (103)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN229_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-104	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.688014058086877	none			PRKCZ_1_00111001	Context-specific genetic dependencies (104)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN235_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-105	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.0246315953609534	none			PRKCZ_1_00111001	Context-specific genetic dependencies (105)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN319_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-106	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.0314161178385034	none			PRKCZ_1_00111001	Context-specific genetic dependencies (106)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN340_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-107	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.295070824922628	none			PRKCZ_1_00111001	Context-specific genetic dependencies (107)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN382_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-108	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.1808166549734	none			PRKCZ_1_00111001	Context-specific genetic dependencies (108)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN428_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-109	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.630436836302745	none			PRKCZ_1_00111001	Context-specific genetic dependencies (109)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN443_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-11	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-1.76139896542211	Decreased shRNA abundance (Z-score < -2)			PRKCZ_1_00111001	Context-specific genetic dependencies (11)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	AGS_STOMACH	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-110	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.0942709086242289	none			PRKCZ_1_00111001	Context-specific genetic dependencies (110)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LN464_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-111	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.234766246457639	none			PRKCZ_1_00111001	Context-specific genetic dependencies (111)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LNZ308_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-112	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.483037575075182	none			PRKCZ_1_00111001	Context-specific genetic dependencies (112)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LOVO_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-113	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.36377986576685	none			PRKCZ_1_00111001	Context-specific genetic dependencies (113)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LS411N_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-114	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.739522981233208	none			PRKCZ_1_00111001	Context-specific genetic dependencies (114)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	LS513_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-115	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-1.27951088623589	none			PRKCZ_1_00111001	Context-specific genetic dependencies (115)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MCF7_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-116	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-1.32835629105794	none			PRKCZ_1_00111001	Context-specific genetic dependencies (116)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MDAMB453_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-117	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.61642607573029	none			PRKCZ_1_00111001	Context-specific genetic dependencies (117)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MIAPACA2_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-118	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.878400296780392	none			PRKCZ_1_00111001	Context-specific genetic dependencies (118)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MKN7_STOMACH	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-119	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.700646253532228	none			PRKCZ_1_00111001	Context-specific genetic dependencies (119)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-12	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.22353614630099	none			PRKCZ_1_00111001	Context-specific genetic dependencies (12)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	AM38_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-120	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.878495339644245	none			PRKCZ_1_00111001	Context-specific genetic dependencies (120)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-121	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.921493762519611	none			PRKCZ_1_00111001	Context-specific genetic dependencies (121)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-122	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.213445979678085	none			PRKCZ_1_00111001	Context-specific genetic dependencies (122)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-123	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.188260397472567	none			PRKCZ_1_00111001	Context-specific genetic dependencies (123)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-124	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.45885178863637	none			PRKCZ_1_00111001	Context-specific genetic dependencies (124)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-125	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.496937927440206	none			PRKCZ_1_00111001	Context-specific genetic dependencies (125)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-126	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.874373102772077	none			PRKCZ_1_00111001	Context-specific genetic dependencies (126)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1299_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-127	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.0486123905655869	none			PRKCZ_1_00111001	Context-specific genetic dependencies (127)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1437_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-128	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.505706241257425	none			PRKCZ_1_00111001	Context-specific genetic dependencies (128)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1650_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-129	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.74389079940285	none			PRKCZ_1_00111001	Context-specific genetic dependencies (129)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1792_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-13	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.867981869944785	none			PRKCZ_1_00111001	Context-specific genetic dependencies (13)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-130	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.0817900138777487	none			PRKCZ_1_00111001	Context-specific genetic dependencies (130)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH196_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-131	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.831752510393406	none			PRKCZ_1_00111001	Context-specific genetic dependencies (131)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH1975_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-132	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.188612383969567	none			PRKCZ_1_00111001	Context-specific genetic dependencies (132)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH2052_PLEURA	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-133	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.161791390100909	none			PRKCZ_1_00111001	Context-specific genetic dependencies (133)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH2122_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-134	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.034904704291256	none			PRKCZ_1_00111001	Context-specific genetic dependencies (134)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH2171_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-135	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.606242991603019	none			PRKCZ_1_00111001	Context-specific genetic dependencies (135)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH23_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-136	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.373978689195782	none			PRKCZ_1_00111001	Context-specific genetic dependencies (136)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH2452_PLEURA	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-137	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.527026252680591	none			PRKCZ_1_00111001	Context-specific genetic dependencies (137)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH441_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-138	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-1.2798001719291	none			PRKCZ_1_00111001	Context-specific genetic dependencies (138)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH508_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-139	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.959020446328483	none			PRKCZ_1_00111001	Context-specific genetic dependencies (139)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH660_PROSTATE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-14	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.379060582198842	none			PRKCZ_1_00111001	Context-specific genetic dependencies (14)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	ASPC1_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-140	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.374670335993358	none			PRKCZ_1_00111001	Context-specific genetic dependencies (140)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH661_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-141	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.0879247384678636	none			PRKCZ_1_00111001	Context-specific genetic dependencies (141)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH716_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-142	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.148852777949438	none			PRKCZ_1_00111001	Context-specific genetic dependencies (142)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIH838_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-143	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.475549822967927	none			PRKCZ_1_00111001	Context-specific genetic dependencies (143)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NCIN87_STOMACH	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-144	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.00169553193902401	none			PRKCZ_1_00111001	Context-specific genetic dependencies (144)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NIHOVCAR3_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-145	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.865680275397526	none			PRKCZ_1_00111001	Context-specific genetic dependencies (145)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-146	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.641241348675714	none			PRKCZ_1_00111001	Context-specific genetic dependencies (146)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OAW42_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-147	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.842240715808941	none			PRKCZ_1_00111001	Context-specific genetic dependencies (147)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-148	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.48403472813959	none			PRKCZ_1_00111001	Context-specific genetic dependencies (148)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-149	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.47921120156277	none			PRKCZ_1_00111001	Context-specific genetic dependencies (149)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-15	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.119344836080974	none			PRKCZ_1_00111001	Context-specific genetic dependencies (15)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	BT20_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-150	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.708833484222172	none			PRKCZ_1_00111001	Context-specific genetic dependencies (150)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OE33_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-151	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.384000014049604	none			PRKCZ_1_00111001	Context-specific genetic dependencies (151)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OELE_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-152	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.266420695465446	none			PRKCZ_1_00111001	Context-specific genetic dependencies (152)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-153	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.29808525990809	none			PRKCZ_1_00111001	Context-specific genetic dependencies (153)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OV7_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-154	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.364427968854391	none			PRKCZ_1_00111001	Context-specific genetic dependencies (154)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OV90_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-155	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.457942869694514	none			PRKCZ_1_00111001	Context-specific genetic dependencies (155)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OVCAR4_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-156	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.995546910179426	none			PRKCZ_1_00111001	Context-specific genetic dependencies (156)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OVCAR8_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-157	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.67503571317334	none			PRKCZ_1_00111001	Context-specific genetic dependencies (157)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	OVISE_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-158	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.246386436051764	none			PRKCZ_1_00111001	Context-specific genetic dependencies (158)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PANC0327_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-159	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.679902967333416	none			PRKCZ_1_00111001	Context-specific genetic dependencies (159)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PANC0813_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-16	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.957221247302832	none			PRKCZ_1_00111001	Context-specific genetic dependencies (16)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	BT474_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-160	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.25328484161163	none			PRKCZ_1_00111001	Context-specific genetic dependencies (160)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PANC1005_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-161	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.338275873278284	none			PRKCZ_1_00111001	Context-specific genetic dependencies (161)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-162	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.60567965208577	none			PRKCZ_1_00111001	Context-specific genetic dependencies (162)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	PSN1_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-163	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.144351423610662	none			PRKCZ_1_00111001	Context-specific genetic dependencies (163)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	QGP1_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-164	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.163475357805922	none			PRKCZ_1_00111001	Context-specific genetic dependencies (164)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-165	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.46486903015477	none			PRKCZ_1_00111001	Context-specific genetic dependencies (165)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RKN_SOFT_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-166	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.00332890311999	none			PRKCZ_1_00111001	Context-specific genetic dependencies (166)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RKO_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-167	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.427607445663313	none			PRKCZ_1_00111001	Context-specific genetic dependencies (167)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RMGI_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-168	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.618470761057609	none			PRKCZ_1_00111001	Context-specific genetic dependencies (168)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RMUGS_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-169	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.0291401252253056	none			PRKCZ_1_00111001	Context-specific genetic dependencies (169)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-17	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.0900333054868905	none			PRKCZ_1_00111001	Context-specific genetic dependencies (17)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	BXPC3_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-170	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.0853950955201952	none			PRKCZ_1_00111001	Context-specific genetic dependencies (170)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	RT112_URINARY_TRACT	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-171	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.06671524505597	none			PRKCZ_1_00111001	Context-specific genetic dependencies (171)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-172	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.536688737891	none			PRKCZ_1_00111001	Context-specific genetic dependencies (172)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SF126_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-173	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.989487256121662	none			PRKCZ_1_00111001	Context-specific genetic dependencies (173)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SF172_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-174	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.539765153934578	none			PRKCZ_1_00111001	Context-specific genetic dependencies (174)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SF295_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-175	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.926739480923579	none			PRKCZ_1_00111001	Context-specific genetic dependencies (175)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SF767_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-176	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.39217807450599	none			PRKCZ_1_00111001	Context-specific genetic dependencies (176)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SJSA1_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-177	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.481116217824226	none			PRKCZ_1_00111001	Context-specific genetic dependencies (177)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKCO1_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-178	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.748607770446834	none			PRKCZ_1_00111001	Context-specific genetic dependencies (178)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKMEL5_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-179	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.17450805172453	none			PRKCZ_1_00111001	Context-specific genetic dependencies (179)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-18	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.924831101696051	none			PRKCZ_1_00111001	Context-specific genetic dependencies (18)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	C2BBE1_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-180	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.264655854759086	none			PRKCZ_1_00111001	Context-specific genetic dependencies (180)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-181	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.33035170426868	none			PRKCZ_1_00111001	Context-specific genetic dependencies (181)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKOV3_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-182	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.0812918237987999	none			PRKCZ_1_00111001	Context-specific genetic dependencies (182)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SKRC20_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-183	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.47080287832018	none			PRKCZ_1_00111001	Context-specific genetic dependencies (183)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR20_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-184	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.957397171972274	none			PRKCZ_1_00111001	Context-specific genetic dependencies (184)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR21_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-185	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.13812761124137	none			PRKCZ_1_00111001	Context-specific genetic dependencies (185)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR23_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-186	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.333520274790304	none			PRKCZ_1_00111001	Context-specific genetic dependencies (186)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR24_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-187	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.174134136864028	none			PRKCZ_1_00111001	Context-specific genetic dependencies (187)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR25_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-188	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.149635042701142	none			PRKCZ_1_00111001	Context-specific genetic dependencies (188)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SLR26_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-189	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.130101453380397	none			PRKCZ_1_00111001	Context-specific genetic dependencies (189)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SNU1105_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-19	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.48811567878049	none			PRKCZ_1_00111001	Context-specific genetic dependencies (19)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	C32_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-190	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.41145390829114	none			PRKCZ_1_00111001	Context-specific genetic dependencies (190)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SNU840_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-191	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.185710240202093	none			PRKCZ_1_00111001	Context-specific genetic dependencies (191)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SNUC1_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-192	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.477895688005383	none			PRKCZ_1_00111001	Context-specific genetic dependencies (192)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SNUC2A_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-193	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-1.11568863489399	none			PRKCZ_1_00111001	Context-specific genetic dependencies (193)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SU8686_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-194	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.392409277101502	none			PRKCZ_1_00111001	Context-specific genetic dependencies (194)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SW1417_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-195	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.468434836491962	none			PRKCZ_1_00111001	Context-specific genetic dependencies (195)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SW1783_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-196	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-1.00432553640808	none			PRKCZ_1_00111001	Context-specific genetic dependencies (196)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SW480_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-197	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.282954331834337	none			PRKCZ_1_00111001	Context-specific genetic dependencies (197)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	SW48_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-198	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-1.35069103060039	none			PRKCZ_1_00111001	Context-specific genetic dependencies (198)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	T98G_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-199	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.264419467135137	none			PRKCZ_1_00111001	Context-specific genetic dependencies (199)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TC71_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-2	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.269476456102333	none			PRKCZ_1_00111001	Context-specific genetic dependencies (2)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-20	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.241100959999305	none			PRKCZ_1_00111001	Context-specific genetic dependencies (20)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CADOES1_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-200	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.666646599246243	none			PRKCZ_1_00111001	Context-specific genetic dependencies (200)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TCCSUP_URINARY_TRACT	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-201	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.0129702817068676	none			PRKCZ_1_00111001	Context-specific genetic dependencies (201)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TE10_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-202	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.536670928811025	none			PRKCZ_1_00111001	Context-specific genetic dependencies (202)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TE15_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-203	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.440535676692905	none			PRKCZ_1_00111001	Context-specific genetic dependencies (203)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TE9_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-204	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.85798160808802	Increased shRNA abundance (Z-score > 2)			PRKCZ_1_00111001	Context-specific genetic dependencies (204)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-205	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.679030247327834	none			PRKCZ_1_00111001	Context-specific genetic dependencies (205)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TOV112D_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-206	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.0567856375272648	none			PRKCZ_1_00111001	Context-specific genetic dependencies (206)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TOV21G_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-207	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.432364619441332	none			PRKCZ_1_00111001	Context-specific genetic dependencies (207)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TT_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-208	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.785520983111559	none			PRKCZ_1_00111001	Context-specific genetic dependencies (208)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	TYKNU_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-209	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.24888398063402	none			PRKCZ_1_00111001	Context-specific genetic dependencies (209)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	U178_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-21	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.942412339786478	none			PRKCZ_1_00111001	Context-specific genetic dependencies (21)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAL120_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-210	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.731374625998921	none			PRKCZ_1_00111001	Context-specific genetic dependencies (210)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	U251MG_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-211	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.336053455130602	none			PRKCZ_1_00111001	Context-specific genetic dependencies (211)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	U343_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-212	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.664296168180005	none			PRKCZ_1_00111001	Context-specific genetic dependencies (212)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	U87MG_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-213	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.502125290803153	none			PRKCZ_1_00111001	Context-specific genetic dependencies (213)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	UOK101_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-214	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.255870437779559	none			PRKCZ_1_00111001	Context-specific genetic dependencies (214)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	VCAP_PROSTATE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-215	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.32892917329126	none			PRKCZ_1_00111001	Context-specific genetic dependencies (215)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	YKG1_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-216	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-1.05862674430622	none			PRKCZ_1_00111001	Context-specific genetic dependencies (216)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	ZR7530_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-22	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.416123099233184	none			PRKCZ_1_00111001	Context-specific genetic dependencies (22)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAL51_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-23	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.3483113326315	none			PRKCZ_1_00111001	Context-specific genetic dependencies (23)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CALU1_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-24	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.0752475174609068	none			PRKCZ_1_00111001	Context-specific genetic dependencies (24)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAOV3_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-25	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.395176695624536	none			PRKCZ_1_00111001	Context-specific genetic dependencies (25)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAOV4_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-26	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.699653026026415	none			PRKCZ_1_00111001	Context-specific genetic dependencies (26)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CAS1_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-27	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.445194840868898	none			PRKCZ_1_00111001	Context-specific genetic dependencies (27)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CFPAC1_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-28	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.955057132212673	none			PRKCZ_1_00111001	Context-specific genetic dependencies (28)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CH157MN_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-29	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.247853949918336	none			PRKCZ_1_00111001	Context-specific genetic dependencies (29)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COLO205_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-3	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.242692885519907	none			PRKCZ_1_00111001	Context-specific genetic dependencies (3)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	786O_KIDNEY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-30	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.728541914387897	none			PRKCZ_1_00111001	Context-specific genetic dependencies (30)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COLO704_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-31	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.657915435946582	none			PRKCZ_1_00111001	Context-specific genetic dependencies (31)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COLO741_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-32	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.116655833317135	none			PRKCZ_1_00111001	Context-specific genetic dependencies (32)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COLO783_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-33	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.800199962055663	none			PRKCZ_1_00111001	Context-specific genetic dependencies (33)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	CORL23_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-34	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.55287984541561	none			PRKCZ_1_00111001	Context-specific genetic dependencies (34)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COV362_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-35	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.323006937492585	none			PRKCZ_1_00111001	Context-specific genetic dependencies (35)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COV434_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-36	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.711809858781386	none			PRKCZ_1_00111001	Context-specific genetic dependencies (36)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COV504_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-37	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.0580311348127745	none			PRKCZ_1_00111001	Context-specific genetic dependencies (37)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	COV644_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-38	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.0937333416708101	none			PRKCZ_1_00111001	Context-specific genetic dependencies (38)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	DBTRG05MG_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-39	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.184901018612036	none			PRKCZ_1_00111001	Context-specific genetic dependencies (39)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	DKMG_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-4	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.30211624445983	none			PRKCZ_1_00111001	Context-specific genetic dependencies (4)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A1207_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-40	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.416359312920043	none			PRKCZ_1_00111001	Context-specific genetic dependencies (40)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	DLD1_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-41	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.0776161139921108	none			PRKCZ_1_00111001	Context-specific genetic dependencies (41)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EFE184_ENDOMETRIUM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-42	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-1.33803159937266	none			PRKCZ_1_00111001	Context-specific genetic dependencies (42)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EFM19_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-43	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.31423192119496	none			PRKCZ_1_00111001	Context-specific genetic dependencies (43)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EFO21_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-44	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.282590595590663	none			PRKCZ_1_00111001	Context-specific genetic dependencies (44)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EFO27_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-45	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.244177545088042	none			PRKCZ_1_00111001	Context-specific genetic dependencies (45)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EW8_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-46	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.965392721184277	none			PRKCZ_1_00111001	Context-specific genetic dependencies (46)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	EWS502_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-47	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.735665006483119	none			PRKCZ_1_00111001	Context-specific genetic dependencies (47)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-48	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.333129809938009	none			PRKCZ_1_00111001	Context-specific genetic dependencies (48)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	GB1_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-49	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.338951756794353	none			PRKCZ_1_00111001	Context-specific genetic dependencies (49)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	GP2D_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-5	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.230065421333006	none			PRKCZ_1_00111001	Context-specific genetic dependencies (5)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A172_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-50	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.514292298448574	none			PRKCZ_1_00111001	Context-specific genetic dependencies (50)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC1187_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-51	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.668448003014948	none			PRKCZ_1_00111001	Context-specific genetic dependencies (51)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC1395_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-52	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.00407397686706	none			PRKCZ_1_00111001	Context-specific genetic dependencies (52)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC1954_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-53	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.877870922039698	none			PRKCZ_1_00111001	Context-specific genetic dependencies (53)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC2218_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-54	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.166332041196801	none			PRKCZ_1_00111001	Context-specific genetic dependencies (54)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC2814_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-55	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.239778021848177	none			PRKCZ_1_00111001	Context-specific genetic dependencies (55)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC364_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-56	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.141661723734363	none			PRKCZ_1_00111001	Context-specific genetic dependencies (56)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC44_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-57	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-1.13485968562418	none			PRKCZ_1_00111001	Context-specific genetic dependencies (57)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC70_BREAST	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-58	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.138124241703444	none			PRKCZ_1_00111001	Context-specific genetic dependencies (58)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC827GR5_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-59	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.04408395459013	none			PRKCZ_1_00111001	Context-specific genetic dependencies (59)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCC827_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-6	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.319735204629399	none			PRKCZ_1_00111001	Context-specific genetic dependencies (6)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A204_SOFT_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-60	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.80262735266161	Increased shRNA abundance (Z-score > 2)			PRKCZ_1_00111001	Context-specific genetic dependencies (60)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HCT116_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-61	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.527138722672059	none			PRKCZ_1_00111001	Context-specific genetic dependencies (61)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HEC1A_ENDOMETRIUM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-62	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.756787998021299	none			PRKCZ_1_00111001	Context-specific genetic dependencies (62)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HEYA8_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-63	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.105572982555818	none			PRKCZ_1_00111001	Context-specific genetic dependencies (63)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-64	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.484495589771007	none			PRKCZ_1_00111001	Context-specific genetic dependencies (64)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HLF_LIVER	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-65	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.613890929530566	none			PRKCZ_1_00111001	Context-specific genetic dependencies (65)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-66	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.481205061956659	none			PRKCZ_1_00111001	Context-specific genetic dependencies (66)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HPAC_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-67	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.326959961689307	none			PRKCZ_1_00111001	Context-specific genetic dependencies (67)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HPAFII_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-68	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.22546289534861	none			PRKCZ_1_00111001	Context-specific genetic dependencies (68)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HS683_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-69	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.000941858141860953	none			PRKCZ_1_00111001	Context-specific genetic dependencies (69)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HS766T_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-7	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.352631152351787	none			PRKCZ_1_00111001	Context-specific genetic dependencies (7)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A2058_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-70	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.550742293926676	none			PRKCZ_1_00111001	Context-specific genetic dependencies (70)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HS944T_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-71	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.230860272513746	none			PRKCZ_1_00111001	Context-specific genetic dependencies (71)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HT1197_URINARY_TRACT	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-72	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-1.475592008601	Decreased shRNA abundance (Z-score < -2)			PRKCZ_1_00111001	Context-specific genetic dependencies (72)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HT29_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-73	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.795723092009435	none			PRKCZ_1_00111001	Context-specific genetic dependencies (73)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HT55_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-74	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.605808596991128	none			PRKCZ_1_00111001	Context-specific genetic dependencies (74)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HUG1N_STOMACH	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-75	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.00716618934526	none			PRKCZ_1_00111001	Context-specific genetic dependencies (75)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	HUTU80_SMALL_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-76	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.0832922719547353	none			PRKCZ_1_00111001	Context-specific genetic dependencies (76)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	IGR39_SKIN	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-77	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.43535626089539	none			PRKCZ_1_00111001	Context-specific genetic dependencies (77)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	IGROV1_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-78	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.187807999202099	none			PRKCZ_1_00111001	Context-specific genetic dependencies (78)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	IOMMLEE_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-79	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-1.15549722415726	none			PRKCZ_1_00111001	Context-specific genetic dependencies (79)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	JHESOAD1_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-8	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.662560211533786	none			PRKCZ_1_00111001	Context-specific genetic dependencies (8)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A549_LUNG	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-80	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.188836435493938	none			PRKCZ_1_00111001	Context-specific genetic dependencies (80)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	JHOC5_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-81	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	2.21141918196452	Increased shRNA abundance (Z-score > 2)			PRKCZ_1_00111001	Context-specific genetic dependencies (81)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	JHOM1_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-82	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.130863838349707	none			PRKCZ_1_00111001	Context-specific genetic dependencies (82)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-83	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.0964196769589467	none			PRKCZ_1_00111001	Context-specific genetic dependencies (83)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-84	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	2.03293520490622	Increased shRNA abundance (Z-score > 2)			PRKCZ_1_00111001	Context-specific genetic dependencies (84)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KALS1_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-85	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.57002283186682	Increased shRNA abundance (Z-score > 2)			PRKCZ_1_00111001	Context-specific genetic dependencies (85)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-86	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.406900089203436	none			PRKCZ_1_00111001	Context-specific genetic dependencies (86)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KM12_LARGE_INTESTINE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-87	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.323907626606879	none			PRKCZ_1_00111001	Context-specific genetic dependencies (87)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-88	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.311377914199941	none			PRKCZ_1_00111001	Context-specific genetic dependencies (88)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KNS60_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-89	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.120998015463621	none			PRKCZ_1_00111001	Context-specific genetic dependencies (89)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KNS81_CENTRAL_NERVOUS_SYSTEM	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-9	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.325864648336048	none			PRKCZ_1_00111001	Context-specific genetic dependencies (9)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	A673_BONE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-90	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.224575344025254	none			PRKCZ_1_00111001	Context-specific genetic dependencies (90)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KP1NL_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-91	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	1.19585677900827	none			PRKCZ_1_00111001	Context-specific genetic dependencies (91)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KP2_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-92	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.0403268592474722	none			PRKCZ_1_00111001	Context-specific genetic dependencies (92)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KP4_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-93	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.448212655889592	none			PRKCZ_1_00111001	Context-specific genetic dependencies (93)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KURAMOCHI_OVARY	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-94	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.805031689627114	none			PRKCZ_1_00111001	Context-specific genetic dependencies (94)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KYSE150_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-95	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.439415483851876	none			PRKCZ_1_00111001	Context-specific genetic dependencies (95)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KYSE30_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-96	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	0.038174985441278	none			PRKCZ_1_00111001	Context-specific genetic dependencies (96)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KYSE450_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-97	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.737500502349159	none			PRKCZ_1_00111001	Context-specific genetic dependencies (97)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	KYSE510_OESOPHAGUS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-98	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.241692703371129	none			PRKCZ_1_00111001	Context-specific genetic dependencies (98)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	L33_PANCREAS	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-99	5590		PRKCZ	TRCN0000001218, TRCN0000001222, TRCN0000010114, TRCN0000010121	-0.0314012681999347	none			PRKCZ_1_00111001	Context-specific genetic dependencies (99)	Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies	Cowley et al.	2014	25984343	Cell line	L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	shRNA abundance	Next-generation sequencing	TRC	shRNA	Genome-wide	Fold change	np (default cutoff applied: Z-score > 2 OR < -2)	Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
	5590	5590	PRKCZ		0.009999999999999995	none
GR00371-A-1	5590	5590	PRKCZ		-0.528045190243	none			Dharmacon	Nanog expression in absence of bFGF and TGFbeta	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-2	5590	PRKCZ	5590		-1.04279716205	none			Dharmacon	Nanog expression in presence of TGFbeta inhibitor	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-3	5590	5590	PRKCZ		-1.53353942096	none			Dharmacon	Nanog expression in presence of MEK inhibitor	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-4	5590	5590	PRKCZ		-1.04693873192	none			Dharmacon	Nanog expression in presence of PI3K inhibitor	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-5	5590	5590	PRKCZ		-1.06125310714	none			Dharmacon	Nanog expression in presence of retinoic acid	Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways	Gonzales et al.	2015	26232226	Cell line	NANOG-GFP H1 hESC	NANOG expression	Fluorescence	Dharmacon and Ambion	Selected genes	siRNA	Z-score	>1,25 OR >1,5 [in at least two replicates]	Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00376-A-1	5590	5590	PRKCZ		0.206204849	none				Mitigators of SS1P-induced immunotoxicity	Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity	Pasetto et al.	2015	25713356	Cell line	KB cells	Viability	Luminescence	Ambion Silencer Select Version 4	Genome-wide	siRNA	RSA P-value	<0.001	SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID
GR00376-A-2	5590	5590	PRKCZ		0.091076253	none				Sensitizers of SS1P-induced immunotoxicity	Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity	Pasetto et al.	2015	25713356	Cell line	KB cells	Viability	Luminescence	Ambion Silencer Select Version 4	Genome-wide	siRNA	RSA P-value	<0.001	SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID
GR00378-A	5590		PRKCZ		-0.247194015	none				Poliovirus vaccine production	Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game	van der Sanden et al.	2015	26581994	Cell line	HEp-2C	Infection with Attenuated Poliovirus	ELISA	Dharmacon	Genome-wide	siRNA	Z-score	>	For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol
	5590	NM_002744	PRKCZ		86.297	none
GR00386-A-1	5590	5590	PRKCZ		106.526575451606	none				NOD2 stimulation by MDP	A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion.	Warner et al.	2014	25170077	Cell line	HEK293 stably expressing NOD2	Viability	Luminescence	Dharmacon	Genome-wide	siRNA	Percentage growth	Decreased: <70, increased: >120	Reagent IDs not provided
GR00386-A-2	5590	5590	PRKCZ		9.2	none				MDP-induced IL-8 secretion	A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion.	Warner et al.	2014	25170077	Cell line	HEK293 stably expressing NOD2	IL-8 secretion	ELISA	Dharmacon	Genome-wide	siRNA	Percent inhibition of IL-8 secretion	Increased: <-300, Decreased: >60	Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided