RNAi

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 6197
  • Symbol: RPS6KA3
  • Description: ribosomal protein S6 kinase A3
DataSource: http://genomernai.dkfz.de/v16/genedetails/6197

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Stable_ID Entrez_ID Gene_ID Gene_Symbol Reagent_ID Score Phenotype Conditions Follow_Up Comment Screen_Title Publication_Title Authors Publication_Year Pubmed_ID Biosource Biomodel Assay Method Library Scope Reagent_Type Score_Type Cutoff Notes
GR00016-A 6197 6197 RPS6KA3 np 1.67 none no Wnt/beta-catenin pathway regulation Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. James et al. 2009 19471023 Cell line RKO Wnt/beta-catenin pathway reporter Luminescence rp Selected genes siRNA Z-score > 2
GR00053-A 6197 NM_004586 RPS6KA3 np sp none no Genome stability A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Paulsen et al. 2009 19647519 Cell line HeLa gamma-H2AX phosphorylation and DNA content Fluorescence siARRAY human genome siRNA library Genome-wide siRNA p-value Complex criteria Confidence groupings from 4 to 1 (highest level of confidence in group 4)
GR00054-A 6197 NM_004586 RPS6KA3 np 0.887 none no Combinatorial effect with paclitaxel Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Whitehurst et al. 2007 17429401 Cell line NCI-H1155 Viability (synthetic lethal) ATP level # G-005000-01 Genome-wide siRNA Paclitaxel/control ratio Complex criteria Additional information about 87 high-confidence hits
6197 6197 RPS6KA3 np np none no
GR00056-A 6197 NM_004586 RPS6KA3 np 0.72 Decreased melanin production yes Melanogenesis Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. Ganesan et al. 2008 19057677 Cell line MNT-1 Melanin protein expression and viability Absorbance and luminescence rp Genome-wide siRNA Normalized absorbance ratio > 2 standard deviations below mean Additional information about a secondary screen (retest to determine false-positive rate)
GR00057-A-1 6197 NM_004586 RPS6KA3 M-003026-01 -0.73 none no Wnt/beta-catenin pathway regulation (1) A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Tang et al. 2008 18621708 Cell line HeLa Wnt pathway reporter Luminescence Human siArray siRNA library Genome-wide siRNA Z-score > 4 Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00057-A-2 6197 NM_004586 RPS6KA3 M-003026-01 sp none no Wnt/beta-catenin pathway regulation (2) A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Tang et al. 2008 18621708 Cell line HeLa Wnt pathway reporter Luminescence Human siArray siRNA library Genome-wide siRNA Complex, SP Complex criteria Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00095-A 6197 NM_004586 RPS6KA3 np np none p53 pathway components A large-scale RNAi screen in human cells identifies new components of the p53 pathway Berns et al. 2004 15042092 Cell line BJ-TERT-tsLT fibroblasts Proliferation Colony-forming cell assay Nki library Genome-wide shRNA np np
GR00098-A-1 6197 ENSG00000177189 RPS6KA3 ENSG00000177189 sp none no Cell division (1) Genome-scale RNAi profiling of cell division in human tissue culture cells. Kittler et al. 2007 17994010 Cell line HeLa Cell number and DNA content Laser scanning cytometry rp Genome-wide esiRNA Complex, sp Complex criteria
GR00110-A-0 6197 RPS6KA3 shRPS6KA3-982 23.9 Increased mitotic index no Cell cycle A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Moffat et al. 2006 16564017 Cell line HT29 Mitotic index High content (microscopy) TRC shRNA library shRNA Mitotic index >
GR00114-A 6197 RPS6KA3 np -0.62 none 107% Combinatorial effect with Poly (ADP‐ribose)‐polymerase‐1 (PARP) A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. Turner et al. 2008 18388863 Cell line CAL51 Viability Luminescence siARRAY SMARTpool Kinases siRNA Z-score < Growth rates (%) for vehicle-alone experiments are given in the comment field.
GR00121-A 6197 RSK2 TRCN0000001394 14.63 none Combinatorial effect with Von Hippel-Lindau (VHL) Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen. Bommi-Reddy et al. 2008 18948595 Cell line 786-O Viability Colorimetric lentiviral library Kinases shRNA Differential loss of viability (%) > Additional screen in RCC4 cells available
GR00123-A 6197 NM_004586 RPS6KA3 102813, 102812, 102811 np none Combinatorial effect with nutlin-3 An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors Brummelkamp et al. 2006 16474381 Cell line MCF-7 Viability Fluoresence Nki library Genome-wide shRNA log2 ratio np
GR00133-A-1 6197 6197 RPS6KA3 np -0.047267 none no Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Misselwitz et al. 2011 21407211 Cell line HeLa Gentamycin protection invasion assay Fluorescence Druggable genome library V2.0 Druggable genes siRNA log2 median Complex criteria
GR00143-A 6197 RPS6KA3 RPS6KA3 s1 sp none no tau phosphorylation High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. Azorsa et al. 2010 20067632 Cell line H4 overexpressing 4RON tau Total tau and 12E8 tau protein expression Fluorescence Validated human kinase siRNA Set 2.0 Kinases siRNA p-value Complex criteria
GR00143-A 6197 RPS6KA3 RPS6KA3 s2 sp none no tau phosphorylation High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. Azorsa et al. 2010 20067632 Cell line H4 overexpressing 4RON tau Total tau and 12E8 tau protein expression Fluorescence Validated human kinase siRNA Set 2.0 Kinases siRNA p-value Complex criteria
GR00151-A-1 6197 ENSG00000177189 RPS6KA3 np 0.403 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (1) A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. SÅ‚abicki et al. 2010 20613862 Cell line HeLa (HR-DSBR) DR-GFP reporter Flow cytometry Custom-made Genome-wide esiRNA Z-score < -2 OR > 2
GR00155-A 6197 6197 RPS6KA3 RPS6KA3_1, RPS6KA3_2, RPS6KA3_3 np none no Aryl hydrocarbon receptor (AhR) transduction pathway regulation RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity. Gilot et al. 2011 21479225 Cell line MCF-7 TCDD-induced CYP1A1-related EROD activity and cell viability Fluorescence and methylene blue MISSION siRNA Human Kinase Panel library Kinases siRNA Z-score Top 150 for >
GR00180-A-1 6197 6197 RPS6KA3 PL-50003 0.911 none no Hepatitis C virus replication (1) A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Tai et al. 2009 19286138 Cell line Huh7/Rep-Feo HCV replicon RNA copy number Luminescence siARRAY Human Genome siRNA Library Genome-wide siRNA q-value Complex criteria
GR00184-A-1 6197 NM_004586 RPS6KA3 M-003026-01 -1.53554611379379 none no Self-renewal and pluripotency in human embryonic stem cells (1) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 POU5F1 protein expression Fluorescence SMARTpool siRNA library Genome-wide siRNA Z-score < -2
GR00193-A-1 6197 6197 RPS6KA3 RPS6KA3 0.962812590564905 none yes Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (1) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line EBC1 Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00193-A-2 6197 6197 RPS6KA3 RPS6KA3 1.01937251585624 none yes Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (2) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line KELLY Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00193-A-3 6197 6197 RPS6KA3 RPS6KA3 0.974250603690741 none yes Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (3) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line SKNAS Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00193-A-4 6197 6197 RPS6KA3 RPS6KA3 1.3723540589509 none no Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (4) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line NLF Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00196-A-1 6197 ENSG00000177189 np sp none no TP53 interactions (1) A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. Krastev et al. 2011 21642980 Cell line HCT116 ( wildtype and TP53 knockout) TP53 protein expression and viability Fluorescence rp Genome-wide esiRNA Complex, sp Complex criteria
GR00197-A-1 6197 6197 RPS6KA3 M-003026-01 -0.288890712 none no Human papillomavirus oncogene expression regulation (1) Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Smith et al. 2010 20133580 Cell line C33A/BE2/18LCR c4 HPV18 LCR reporter activity Luminescence Human siGENOME SMARTpool library Genome-wide siRNA Z-score > Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5
GR00210-A 6197 6197 RPS6KA3 np sp none no Focal adhesion formation Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown. Winograd-Katz et al. 2009 19667130 Cell line HeLa paxillin protein expression Fluorescence SMARTpool siARRAY siRNA Libraries Kinases, phosphatases and selected genes siRNA Z-score > 3.5 OR < -3.5
GR00221-A-1 6197 RPS6KA3 TRCN0000001396 -0.61 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 6197 RPS6KA3 TRCN0000001397 -0.28 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 6197 RPS6KA3 TRCN0000001398 0.71 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 6197 RPS6KA3 TRCN0000001395 0.92 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 6197 RPS6KA3 TRCN0000001396 -1.43 Decreased viability yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 6197 RPS6KA3 TRCN0000001395 -0.38 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 6197 RPS6KA3 TRCN0000001398 0.08 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 6197 RPS6KA3 TRCN0000001397 0.09 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 6197 RPS6KA3 TRCN0000001396 -0.31 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 6197 RPS6KA3 TRCN0000001397 0 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 6197 RPS6KA3 TRCN0000001398 0.73 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 6197 RPS6KA3 TRCN0000001395 0.74 none yes Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6197 RPS6KA3 TRCN0000001397 -0.44 none no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6197 RPS6KA3 TRCN0000001398 -0.18 none no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6197 RPS6KA3 TRCN0000001395 -0.03 none no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6197 RPS6KA3 TRCN0000001396 0.78 none no Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00224-A-1 6197 6197 RPS6KA3 np sp Decreased HIV-LTR-beta-galactosidase protein expression yes library: Proligo HIV-1 infection (1) Genome-scale RNAi screen for host factors required for HIV replication. Zhou et al. 2008 18976975 Cell line HeLa HIV-LTR-beta-galactosidase protein expression Luminescence np Selected genes siRNA Complex, sp Complex criteria Additional information about the primary genome-wide screen
GR00224-A-2 6197 6197 RPS6KA3 np sp none no library: Proligo HIV-1 infection (2) Genome-scale RNAi screen for host factors required for HIV replication. Zhou et al. 2008 18976975 Cell line HeLa HIV-Tat and HIV-LTR-beta-galactosidase protein expression Luminescence np Selected genes siRNA Percentage < 60 % Additional information about the primary genome-wide screen
GR00225-A 6197 RPS6KA3 RPS6KA3_A -0.938031 none 10nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
GR00225-A 6197 RPS6KA3 RPS6KA3_B 0.038203 none 5nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
GR00225-A 6197 RPS6KA3 RPS6KA3_B -1.064498 none 10nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
GR00225-A 6197 RPS6KA3 RPS6KA3_A -0.074674 none 5nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
6197 NM_004586 RPS6KA3 np 1.025073 none no
GR00230-A-1 6197 NM_004586 RPS6KA3 TRCN0000001395 4.72 Increased cell viability after pRB stimulation yes pRB-induced cell cycle regulation (1) A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Tschöp et al. 2011 21498571 Cell line SaOS2-TR-pRB Cell number and viability Colorimetrics Lentiviral shRNA library Kinases shRNA SD from the trendline > 3.0 OR < -3.0 for >
GR00230-A-1 6197 NM_004586 RPS6KA3 TRCN0000001396 4.15 Increased cell viability after pRB stimulation yes pRB-induced cell cycle regulation (1) A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Tschöp et al. 2011 21498571 Cell line SaOS2-TR-pRB Cell number and viability Colorimetrics Lentiviral shRNA library Kinases shRNA SD from the trendline > 3.0 OR < -3.0 for >
GR00230-A-1 6197 NM_004586 RPS6KA3 TRCN0000001397 3.13 Increased cell viability after pRB stimulation yes pRB-induced cell cycle regulation (1) A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Tschöp et al. 2011 21498571 Cell line SaOS2-TR-pRB Cell number and viability Colorimetrics Lentiviral shRNA library Kinases shRNA SD from the trendline > 3.0 OR < -3.0 for >
GR00230-A-1 6197 NM_004586 RPS6KA3 TRCN0000010428 np none yes Z-score >|3| for >= 2 shRNAs pRB-induced cell cycle regulation (1) A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Tschöp et al. 2011 21498571 Cell line SaOS2-TR-pRB Cell number and viability Colorimetrics Lentiviral shRNA library Kinases shRNA SD from the trendline > 3.0 OR < -3.0 for >
GR00230-A-1 6197 NM_004586 RPS6KA3 TRCN0000001394 np none yes Z-score >|3| for >= 2 shRNAs pRB-induced cell cycle regulation (1) A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Tschöp et al. 2011 21498571 Cell line SaOS2-TR-pRB Cell number and viability Colorimetrics Lentiviral shRNA library Kinases shRNA SD from the trendline > 3.0 OR < -3.0 for >
GR00231-A 6197 NM_004586 RPS6KA3 M-003026-01 0.001 none yes Cell proliferation Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation. Zhang et al. 2011 21765947 Cell line HeLa Viability Electrical impedance Human siARRAY - Protein Kinase and Cell Cycle libraries Kinases and selected genes siRNA Z-score < -1.96 OR > 1.96 Additional information about cell titer blue cell viability screen
GR00234-A-1 6197 NM_004586 RPS6KA3 np sp none no decreased vesicular stomatitis virus pseudoparticles (VSVpp) infection Hepatitis C virus (HCV) infection (1) EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Lupberger et al. 2011 21516087 Cell line Huh7 Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) protein expression Luminescence Human Kinase RNAi Set V2.0 Kinases siRNA Complex, sp Complex criteria
GR00236-A-1 6197 6197 RPS6KA3 M-003026-01 0.639520271043258 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (1) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Adamson et al. 2012 22344029 Cell line DR-U2OS (HR-DSBR) DR-GFP reporter and DNA content Fluorescence Human siGENOME siRNA (G-005000-05) Genome-wide siRNA Relative HR ratio < ~0.4 OR > 1.88 Cutoff values correspond 2 standard deviations from the screen-wide mean
GR00240-S-1 6197 NM_004586 RPS6KA3 M-003026-01 0.81 none yes TRAIL-induced apoptosis (1) A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. Kranz and Boutros 2014 24442637 Cell line U251MG Viability Luminescence SMART-pool siRNA Genome-wide siRNA Z-score > 4 Author-submitted data
GR00240-S-2 6197 NM_004586 RPS6KA3 M-003026-01 0.58 none no Z-score 1.6685 TRAIL-induced apoptosis (2) A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. Kranz and Boutros 2014 24442637 Cell line U251MG Viability (synthetic lethal) Luminescence SMART-pool siRNA Genome-wide siRNA Differential score > 3.6 AND viability Z-score < 4 Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen.
GR00242-A-1 6197 NM_004586 RPS6KA3 np sp none no Selective autophagy regulation (1) Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl et al. 2011 22020285 Cell line HeLa/GFP-LC3 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression Fluorescence siGenome Genome-wide siRNA Z-score Complex criteria
GR00247-A-1 6197 RPS6KA3 np sp none rank: 6908 Regulation of FOXO1 nuclear localization (1) Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Senapedis et al. 2011 21460183 Cell line U2OS EGFP-FOXO1a protein expression and DNA content Fluorescence Human Genome library Genome-wide siRNA Complex, sp Complex criteria
GR00248-A 6197 NM_004586 RPS6KA3 RPS6KA3_siRNA1 -2.207 Decreased human cytomegalovirus (HCMV) strain AD169 replication gene: decreased replication Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00248-A 6197 NM_004586 RPS6KA3 RPS6KA3_siRNA2 -0.346 none gene: decreased replication Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00248-A 6197 NM_004586 RPS6KA3 RPS6KA3_siRNA3 -3.78 Decreased human cytomegalovirus (HCMV) strain AD169 replication gene: decreased replication Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00249-S 6197 6197 RPS6KA3 M-003026-02 1.0652 Increased vaccinia virus (VACV) infection no number of cells compared to control (%): 86.65 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 6197 6197 RPS6KA3 s12279 0.03782 none no number of cells compared to control (%): 92.12 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 6197 6197 RPS6KA3 s12280 0.24759 none no number of cells compared to control (%): 95.62 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 6197 6197 RPS6KA3 s12281 -0.2849 none no number of cells compared to control (%): 88.94 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 6197 6197 RPS6KA3 J-003026-09 1.32463 Increased vaccinia virus (VACV) infection no number of cells compared to control (%): 73.58 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00253-A 6197 NM_004586 RPS6KA3 np 0.019 none hepcidin regulation Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Mleczko-Sanecka et al. 2014 24385536 Cell line Huh7 hepcidin::fluc mRNA expression Luminescence siGenome siARRAY SMARTpool Genome-wide siRNA Z-score > Cutoff <
GR00255-A-1 6197 6197 RPS6KA3 TRCN0000001394, TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000010429, TRCN0000040143, TRCN0000040144, TRCN0000040145, TRCN0000040146, TRCN0000040147 -0.104055511 none Negative genetic interactions (1) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-2 6197 6197 RPS6KA3 TRCN0000001394, TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000010429, TRCN0000040143, TRCN0000040144, TRCN0000040145, TRCN0000040146, TRCN0000040147 -0.253201137 none Negative genetic interactions (2) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-3 6197 6197 RPS6KA3 TRCN0000001394, TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000010429, TRCN0000040143, TRCN0000040144, TRCN0000040145, TRCN0000040146, TRCN0000040147 0.031530099 none Negative genetic interactions (3) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-4 6197 6197 RPS6KA3 TRCN0000001394, TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000010429, TRCN0000040143, TRCN0000040144, TRCN0000040145, TRCN0000040146, TRCN0000040147 -0.293083184 none Negative genetic interactions (4) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-5 6197 6197 RPS6KA3 TRCN0000001394, TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000010429, TRCN0000040143, TRCN0000040144, TRCN0000040145, TRCN0000040146, TRCN0000040147 -0.296388445 none Negative genetic interactions (5) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -0.8 HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00256-A 6197 NM_004586 RPS6KA3 np sp none Kinase-mediated spindle orientation ABL1 regulates spindle orientation in adherent cells and mammalian skin. Matsumara et al. 2012 22252550 Cell line HeLa beta-tubulin protein expression and DNA content Fluorescence Silencer Kinase siRNA library (AM80010V3) Kinases siRNA Complex, sp Complex criteria HeLa cells stably expressing GFP-H2B (HeLa-GH2B) used. Additional information about secondary screens.
GR00257-A-1 6197 rps6ka3 554 sp Increased viability (proliferation) Cell division, migration and survival (1) Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Neumann et al. 2010 20360735 Cell line HeLa H2B-GFP protein expression Fluorescence Mapped using ENSEMBL genome database version 27 Selected genes siRNA Complex, sp Complex criteria HeLa-H2B-GFP cells used.
GR00257-A-1 6197 rps6ka3 555 sp Dynamic nuclei (hole, folded or small irregular) Cell division, migration and survival (1) Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Neumann et al. 2010 20360735 Cell line HeLa H2B-GFP protein expression Fluorescence Mapped using ENSEMBL genome database version 27 Selected genes siRNA Complex, sp Complex criteria HeLa-H2B-GFP cells used.
GR00293-A 6197 RPS6KA3 np -2.565 Decreased viability with paclitaxel Combinatorial effect with paclitaxel Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death Sinnott et al. 2014 24860162 Cell line HCC366 Viability Luminescence Thermo-Fisher Genome-wide siRNA Z-score < -2.5 Final hits according to the author are indicated in the comment.
GR00300-A 6197 RPS6KA3 TRCN0000010429, TRCN0000010428, TRCN0000040147, TRCN0000040146, TRCN0000197173, TRCN0000194921, TRCN0000194851, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000040144, TRCN0000040145, TRCN0000196642, TRCN0000040143, TRCN0000194806, TRCN0000001394, TRCN0000001395 0 none Combinatorial effect with RAF inhibitor PLX4720 A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Whittaker et al. 2013 23288408 Cell line A375 shRNA abundance Sequencing TRC Genome-wide shRNA Number of shRNAs ranked Top1000 > 2 The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors.
GR00310-A-1 6197 6197 RPS6KA3 np -0.78 none Sindbis virus (SINV) infection (1) Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry Ooi et al. 2013 24367265 Cell line U2OS Sindbis virus (SINV) reporter Luminescence Ambion Silencer V3 Genome-wide siRNA Z-score < -3 OR > 2
6197 6197 RPS6KA3 np 14.1 none 93,2% viability
GR00313-A 6197 NM_004586 RPS6KA3 np 0.95 none TNF-alpha pathway regulation A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. Nickles et al. 2012 22733992 Cell line HEK293T NFkappaB pathway reporter Luminescence Qiagen Genome-wide siRNA Z-score < Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%.
GR00318-A 6197 6197 RPS6KA3 np 0.996 none siRNA set: kinase Huntingtin toxicity A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease Miller et al. 2012 23209424 Cell line HEK293T Caspase 3/7 activity Fluorescence Dharmacon Selected genes siRNA Sum of normalized caspase 3/7 activity mean and standard error < 0.683 HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP).
GR00327-A 6197 1210 RAD52 CLL-H-022044 -0.7693739169691053 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 6197 4383 PSAP CLL-H-021316 0.5974554404682375 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 6197 4383 PSAP CLL-H-021314 np none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 6197 4383 PSAP CLL-H-021315 0.7198414905837652 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 6197 1210 RAD52 CLL-H-022046 -0.2574225555743704 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 6197 4383 PSAP CLL-H-021313 -1.1193089740645188 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 6197 1210 RAD52 CLL-H-022045 1.3473413948849062 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 6197 1210 RAD52 CLL-H-022042 -1.3016401364570775 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 6197 1210 RAD52 CLL-H-022047 -0.4829850276680273 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 6197 1210 RAD52 CLL-H-022043 np none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00327-A 6197 4383 PSAP CLL-H-021312 0.6647210772507987 none Tumor formation An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation Wolf et al. 2013 24292671 Cell line SUM-149 shRNA abundance Next-generation sequencing Decipher library module 1 Selected genes shRNA Z-score > 2.24 Genes were scored as hit if at least 2 shRNAs scored as hit, see comment.
GR00342-S-1 6197 RPS6KA3 M-003026-01 -1.6635520012360452 Decreased viability Viability of Mesenchymal Stem Cells (MSC) (1) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 1, MSC preparation 1 (MSC1a)
GR00342-S-2 6197 RPS6KA3 M-003026-01 -0.5790558459648976 none Viability of Mesenchymal Stem Cells (MSC) (2) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 1, MSC preparation 2 (MSC1b)
GR00342-S-3 6197 RPS6KA3 M-003026-01 0.5964822597409465 none Viability of Mesenchymal Stem Cells (MSC) (3) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 2, MSC preparation 1 (MSC2)
GR00343-S 6197 6197 RPS6KA3 TRCN0000040146 1.3200000000000003 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6197 6197 RPS6KA3 TRCN0000001396 0.4225000000000012 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6197 6197 RPS6KA3 TRCN0000001395 1.0274999999999999 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6197 6197 RPS6KA3 TRCN0000010428 0.22750000000000092 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6197 6197 RPS6KA3 TRCN0000001394 1.4974999999999996 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6197 6197 RPS6KA3 TRCN0000001398 -1.2200000000000006 shRNA abundance <= 50% Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6197 6197 RPS6KA3 TRCN0000001397 -0.27999999999999936 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6197 6197 RPS6KA3 TRCN0000040144 -0.9850000000000012 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6197 6197 RPS6KA3 TRCN0000040145 0.0649999999999995 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6197 6197 RPS6KA3 TRCN0000040143 0.7475000000000023 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6197 6197 RPS6KA3 TRCN0000010429 -0.027499999999999858 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6197 6197 RPS6KA3 TRCN0000040147 0.40000000000000036 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00356-A-1 6197 NM_004586 RPS6KA3 np 0.5 none Clathrin-mediated endocytosis Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Pelkmans et al. 2005 15889048 Cell line HeLa Vesicular stomatitis virus (VSV) infection (rVSV–GFP expression) Fluorescence Ambion Kinases siRNA Relative infection index (RII) < The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Caveolin- and lipid raft-mediated endocytosis" using simian virus 40 (SV40).
GR00356-A-2 6197 NM_004586 RPS6KA3 np 0.5923765810193959 none Caveolin- and lipid raft-mediated endocytosis Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Pelkmans et al. 2005 15889048 Cell line HeLa Simian virus 40 (SV40) infection (SV40 large T-antigen expression) Fluorescence Ambion Kinases siRNA Relative infection index (RII) < The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Clathrin-mediated endocytosis" using vesicular stomatitis virus (VSV).
GR00356-A-3 6197 NM_004586 RPS6KA3 np np none Endocytosis regulation Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Pelkmans et al. 2005 15889048 Cell line HeLa Transferrin (Tfn) uptake and trafficking Fluorescence Ambion Kinases siRNA np np
GR00363-A 6197 6197 RPS6KA3 SI00288190, SI00065674, esi13693, 554, 555, SI00288197, 553, SI00065667 sp Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis strong Endocytosis regulation Systems survey of endocytosis by multiparametric image analysis. Collinet et al. 2010 20190736 Cell line HeLa Transferrin (TF) and epidermal growth factor (EGF) subcellular localisation, DNA content Fluorescence Ambion, Qiagen and esiRNA library (Kittler et al.) Genome-wide siRNA Complex, sp Complex criteria Two hit categories: "strong" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn > 0.95) and "weak but specific" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn < 0.95 but Phenoscore > 0.95). Additional information about secondary screens with kinase and phospatase libraries.
GR00366-A-1 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.487048250293358 none RPS6KA3_1_111111111 Context-specific genetic dependencies (1) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 22RV1_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-10 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.321898440807793 none RPS6KA3_1_111111111 Context-specific genetic dependencies (10) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ACHN_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-100 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.467692860416261 none RPS6KA3_1_111111111 Context-specific genetic dependencies (100) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-101 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.332708989669718 none RPS6KA3_1_111111111 Context-specific genetic dependencies (101) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LK2_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-102 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.344560306424951 none RPS6KA3_1_111111111 Context-specific genetic dependencies (102) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN215_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-103 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.349320540470094 none RPS6KA3_1_111111111 Context-specific genetic dependencies (103) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN229_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-104 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -1.16709723633095 Decreased shRNA abundance (Z-score < -2) RPS6KA3_1_111111111 Context-specific genetic dependencies (104) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN235_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-105 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.00115723269236492 none RPS6KA3_1_111111111 Context-specific genetic dependencies (105) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN319_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-106 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.195253210278315 none RPS6KA3_1_111111111 Context-specific genetic dependencies (106) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN340_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-107 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.328909763801717 none RPS6KA3_1_111111111 Context-specific genetic dependencies (107) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN382_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-108 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.109367379533177 none RPS6KA3_1_111111111 Context-specific genetic dependencies (108) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN428_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-109 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.671435633862527 none RPS6KA3_1_111111111 Context-specific genetic dependencies (109) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN443_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-11 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.761414333576895 none RPS6KA3_1_111111111 Context-specific genetic dependencies (11) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AGS_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-110 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.124344249888462 none RPS6KA3_1_111111111 Context-specific genetic dependencies (110) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN464_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-111 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.390107099291651 none RPS6KA3_1_111111111 Context-specific genetic dependencies (111) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LNZ308_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-112 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.579854485332704 none RPS6KA3_1_111111111 Context-specific genetic dependencies (112) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LOVO_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-113 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -1.2330209540816 Decreased shRNA abundance (Z-score < -2) RPS6KA3_1_111111111 Context-specific genetic dependencies (113) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LS411N_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-114 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.518761063992674 none RPS6KA3_1_111111111 Context-specific genetic dependencies (114) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LS513_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-115 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.328374345456356 none RPS6KA3_1_111111111 Context-specific genetic dependencies (115) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MCF7_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-116 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.358075724962717 none RPS6KA3_1_111111111 Context-specific genetic dependencies (116) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MDAMB453_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-117 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.24709793779705 none RPS6KA3_1_111111111 Context-specific genetic dependencies (117) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MIAPACA2_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-118 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.291314050012391 none RPS6KA3_1_111111111 Context-specific genetic dependencies (118) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MKN7_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-119 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.870765146211747 none RPS6KA3_1_111111111 Context-specific genetic dependencies (119) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-12 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.397480996525855 none RPS6KA3_1_111111111 Context-specific genetic dependencies (12) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AM38_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-120 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.794779996013216 none RPS6KA3_1_111111111 Context-specific genetic dependencies (120) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-121 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.739203963815185 none RPS6KA3_1_111111111 Context-specific genetic dependencies (121) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-122 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.330909023662037 none RPS6KA3_1_111111111 Context-specific genetic dependencies (122) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-123 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.104620399879623 none RPS6KA3_1_111111111 Context-specific genetic dependencies (123) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-124 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.538962378446814 none RPS6KA3_1_111111111 Context-specific genetic dependencies (124) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-125 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.150884288631087 none RPS6KA3_1_111111111 Context-specific genetic dependencies (125) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-126 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.809039180200343 none RPS6KA3_1_111111111 Context-specific genetic dependencies (126) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1299_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-127 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.0412987682866978 none RPS6KA3_1_111111111 Context-specific genetic dependencies (127) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1437_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-128 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.0421356091604858 none RPS6KA3_1_111111111 Context-specific genetic dependencies (128) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1650_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-129 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0816005684764112 none RPS6KA3_1_111111111 Context-specific genetic dependencies (129) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1792_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-13 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0340437731622602 none RPS6KA3_1_111111111 Context-specific genetic dependencies (13) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-130 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.970406564254063 none RPS6KA3_1_111111111 Context-specific genetic dependencies (130) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH196_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-131 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.890861231541787 none RPS6KA3_1_111111111 Context-specific genetic dependencies (131) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1975_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-132 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0329715214157233 none RPS6KA3_1_111111111 Context-specific genetic dependencies (132) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2052_PLEURA shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-133 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.10456350161715 none RPS6KA3_1_111111111 Context-specific genetic dependencies (133) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2122_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-134 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.274350866292312 none RPS6KA3_1_111111111 Context-specific genetic dependencies (134) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2171_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-135 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.422973812617199 none RPS6KA3_1_111111111 Context-specific genetic dependencies (135) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH23_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-136 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.638189398639321 none RPS6KA3_1_111111111 Context-specific genetic dependencies (136) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2452_PLEURA shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-137 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.733373349991512 none RPS6KA3_1_111111111 Context-specific genetic dependencies (137) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH441_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-138 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.720329542795327 none RPS6KA3_1_111111111 Context-specific genetic dependencies (138) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH508_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-139 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.355367671126878 none RPS6KA3_1_111111111 Context-specific genetic dependencies (139) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH660_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-14 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.385858262164337 none RPS6KA3_1_111111111 Context-specific genetic dependencies (14) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ASPC1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-140 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.569605906991467 none RPS6KA3_1_111111111 Context-specific genetic dependencies (140) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH661_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-141 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.130100832744539 none RPS6KA3_1_111111111 Context-specific genetic dependencies (141) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH716_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-142 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.81295119172066 none RPS6KA3_1_111111111 Context-specific genetic dependencies (142) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH838_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-143 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.102485618031928 none RPS6KA3_1_111111111 Context-specific genetic dependencies (143) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIN87_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-144 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.505143787178957 none RPS6KA3_1_111111111 Context-specific genetic dependencies (144) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NIHOVCAR3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-145 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 1.45789550012433 Increased shRNA abundance (Z-score > 2) RPS6KA3_1_111111111 Context-specific genetic dependencies (145) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-146 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.194197331903073 none RPS6KA3_1_111111111 Context-specific genetic dependencies (146) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OAW42_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-147 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 1.22592235639916 Increased shRNA abundance (Z-score > 2) RPS6KA3_1_111111111 Context-specific genetic dependencies (147) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-148 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.311580832511754 none RPS6KA3_1_111111111 Context-specific genetic dependencies (148) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-149 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.929220475436916 none RPS6KA3_1_111111111 Context-specific genetic dependencies (149) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-15 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.792302847894477 none RPS6KA3_1_111111111 Context-specific genetic dependencies (15) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BT20_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-150 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.146058909117273 none RPS6KA3_1_111111111 Context-specific genetic dependencies (150) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OE33_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-151 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.531728344523113 none RPS6KA3_1_111111111 Context-specific genetic dependencies (151) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OELE_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-152 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.119335671592405 none RPS6KA3_1_111111111 Context-specific genetic dependencies (152) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-153 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.393306900796668 none RPS6KA3_1_111111111 Context-specific genetic dependencies (153) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OV7_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-154 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.126517539774828 none RPS6KA3_1_111111111 Context-specific genetic dependencies (154) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OV90_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-155 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.17360962606054 none RPS6KA3_1_111111111 Context-specific genetic dependencies (155) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVCAR4_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-156 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.650024447669257 none RPS6KA3_1_111111111 Context-specific genetic dependencies (156) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVCAR8_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-157 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.773442515791542 none RPS6KA3_1_111111111 Context-specific genetic dependencies (157) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVISE_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-158 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.0547378284613133 none RPS6KA3_1_111111111 Context-specific genetic dependencies (158) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC0327_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-159 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.339505537264337 none RPS6KA3_1_111111111 Context-specific genetic dependencies (159) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC0813_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-16 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.0266269706343586 none RPS6KA3_1_111111111 Context-specific genetic dependencies (16) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BT474_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-160 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.326092540681215 none RPS6KA3_1_111111111 Context-specific genetic dependencies (160) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC1005_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-161 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.307431834557703 none RPS6KA3_1_111111111 Context-specific genetic dependencies (161) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-162 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.37914124054049 none RPS6KA3_1_111111111 Context-specific genetic dependencies (162) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PSN1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-163 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0414177371577345 none RPS6KA3_1_111111111 Context-specific genetic dependencies (163) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line QGP1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-164 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.510754565664286 none RPS6KA3_1_111111111 Context-specific genetic dependencies (164) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-165 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.278262768776112 none RPS6KA3_1_111111111 Context-specific genetic dependencies (165) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RKN_SOFT_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-166 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.288747230971985 none RPS6KA3_1_111111111 Context-specific genetic dependencies (166) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RKO_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-167 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.328933429686115 none RPS6KA3_1_111111111 Context-specific genetic dependencies (167) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RMGI_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-168 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.226267852131011 none RPS6KA3_1_111111111 Context-specific genetic dependencies (168) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RMUGS_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-169 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.258028703072498 none RPS6KA3_1_111111111 Context-specific genetic dependencies (169) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-17 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.734639480124588 none RPS6KA3_1_111111111 Context-specific genetic dependencies (17) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BXPC3_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-170 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.4101296202378 none RPS6KA3_1_111111111 Context-specific genetic dependencies (170) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RT112_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-171 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.360340086019379 none RPS6KA3_1_111111111 Context-specific genetic dependencies (171) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-172 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.116669973399674 none RPS6KA3_1_111111111 Context-specific genetic dependencies (172) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF126_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-173 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.463080762328389 none RPS6KA3_1_111111111 Context-specific genetic dependencies (173) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF172_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-174 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.088067645522049 none RPS6KA3_1_111111111 Context-specific genetic dependencies (174) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF295_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-175 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.517184796832863 none RPS6KA3_1_111111111 Context-specific genetic dependencies (175) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF767_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-176 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.673466890848702 none RPS6KA3_1_111111111 Context-specific genetic dependencies (176) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SJSA1_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-177 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -1.48654960638023 Decreased shRNA abundance (Z-score < -2) RPS6KA3_1_111111111 Context-specific genetic dependencies (177) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKCO1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-178 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.00269183975182102 none RPS6KA3_1_111111111 Context-specific genetic dependencies (178) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKMEL5_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-179 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0103595437803481 none RPS6KA3_1_111111111 Context-specific genetic dependencies (179) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-18 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.0829268714081911 none RPS6KA3_1_111111111 Context-specific genetic dependencies (18) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line C2BBE1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-180 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.346689056877347 none RPS6KA3_1_111111111 Context-specific genetic dependencies (180) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-181 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.31828971156435 none RPS6KA3_1_111111111 Context-specific genetic dependencies (181) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKOV3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-182 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.58219421159282 none RPS6KA3_1_111111111 Context-specific genetic dependencies (182) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKRC20_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-183 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.260694452669758 none RPS6KA3_1_111111111 Context-specific genetic dependencies (183) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR20_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-184 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -1.06196729115685 none RPS6KA3_1_111111111 Context-specific genetic dependencies (184) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR21_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-185 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.295400014862736 none RPS6KA3_1_111111111 Context-specific genetic dependencies (185) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR23_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-186 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.168867218936215 none RPS6KA3_1_111111111 Context-specific genetic dependencies (186) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR24_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-187 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.0544719798304878 none RPS6KA3_1_111111111 Context-specific genetic dependencies (187) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR25_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-188 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.240361497451319 none RPS6KA3_1_111111111 Context-specific genetic dependencies (188) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR26_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-189 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.00257350480536301 none RPS6KA3_1_111111111 Context-specific genetic dependencies (189) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNU1105_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-19 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.489558888416051 none RPS6KA3_1_111111111 Context-specific genetic dependencies (19) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line C32_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-190 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.519733383925336 none RPS6KA3_1_111111111 Context-specific genetic dependencies (190) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNU840_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-191 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.401268865926411 none RPS6KA3_1_111111111 Context-specific genetic dependencies (191) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNUC1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-192 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.111593239229484 none RPS6KA3_1_111111111 Context-specific genetic dependencies (192) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNUC2A_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-193 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.140072477148849 none RPS6KA3_1_111111111 Context-specific genetic dependencies (193) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SU8686_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-194 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.529301559404624 none RPS6KA3_1_111111111 Context-specific genetic dependencies (194) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW1417_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-195 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.147863896189595 none RPS6KA3_1_111111111 Context-specific genetic dependencies (195) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW1783_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-196 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.48241984288937 none RPS6KA3_1_111111111 Context-specific genetic dependencies (196) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW480_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-197 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.944342792881627 none RPS6KA3_1_111111111 Context-specific genetic dependencies (197) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW48_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-198 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.423876195550557 none RPS6KA3_1_111111111 Context-specific genetic dependencies (198) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line T98G_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-199 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.153947441688501 none RPS6KA3_1_111111111 Context-specific genetic dependencies (199) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TC71_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-2 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.125935185352278 none RPS6KA3_1_111111111 Context-specific genetic dependencies (2) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-20 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.104188384496463 none RPS6KA3_1_111111111 Context-specific genetic dependencies (20) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CADOES1_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-200 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.53658487411207 none RPS6KA3_1_111111111 Context-specific genetic dependencies (200) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TCCSUP_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-201 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.400250423031492 none RPS6KA3_1_111111111 Context-specific genetic dependencies (201) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE10_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-202 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.729199757789525 none RPS6KA3_1_111111111 Context-specific genetic dependencies (202) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE15_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-203 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.358577809070972 none RPS6KA3_1_111111111 Context-specific genetic dependencies (203) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE9_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-204 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.839131291519812 none RPS6KA3_1_111111111 Context-specific genetic dependencies (204) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-205 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.14705995331299 none RPS6KA3_1_111111111 Context-specific genetic dependencies (205) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TOV112D_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-206 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0934772272172657 none RPS6KA3_1_111111111 Context-specific genetic dependencies (206) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TOV21G_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-207 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.018171599414816 none RPS6KA3_1_111111111 Context-specific genetic dependencies (207) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TT_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-208 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.779804689400022 none RPS6KA3_1_111111111 Context-specific genetic dependencies (208) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TYKNU_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-209 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.818941302644834 none RPS6KA3_1_111111111 Context-specific genetic dependencies (209) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U178_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-21 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.0549611464984753 none RPS6KA3_1_111111111 Context-specific genetic dependencies (21) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAL120_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-210 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.693048107588877 none RPS6KA3_1_111111111 Context-specific genetic dependencies (210) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U251MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-211 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.00602599518849621 none RPS6KA3_1_111111111 Context-specific genetic dependencies (211) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U343_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-212 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.445770235841507 none RPS6KA3_1_111111111 Context-specific genetic dependencies (212) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U87MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-213 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.37011113953981 none RPS6KA3_1_111111111 Context-specific genetic dependencies (213) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line UOK101_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-214 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.481496462595754 none RPS6KA3_1_111111111 Context-specific genetic dependencies (214) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line VCAP_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-215 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.468164091085726 none RPS6KA3_1_111111111 Context-specific genetic dependencies (215) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line YKG1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-216 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.362767099162602 none RPS6KA3_1_111111111 Context-specific genetic dependencies (216) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ZR7530_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-22 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.306941577550992 none RPS6KA3_1_111111111 Context-specific genetic dependencies (22) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAL51_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-23 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.46085081390964 none RPS6KA3_1_111111111 Context-specific genetic dependencies (23) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CALU1_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-24 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.0559750580359525 none RPS6KA3_1_111111111 Context-specific genetic dependencies (24) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAOV3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-25 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.35315655595965 none RPS6KA3_1_111111111 Context-specific genetic dependencies (25) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAOV4_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-26 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0788992705145022 none RPS6KA3_1_111111111 Context-specific genetic dependencies (26) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAS1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-27 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -1.03972072082822 none RPS6KA3_1_111111111 Context-specific genetic dependencies (27) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CFPAC1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-28 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -1.14983066225656 Decreased shRNA abundance (Z-score < -2) RPS6KA3_1_111111111 Context-specific genetic dependencies (28) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CH157MN_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-29 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.689165200011281 none RPS6KA3_1_111111111 Context-specific genetic dependencies (29) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO205_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-3 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -1.1169439499255 none RPS6KA3_1_111111111 Context-specific genetic dependencies (3) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 786O_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-30 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.105468181934596 none RPS6KA3_1_111111111 Context-specific genetic dependencies (30) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO704_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-31 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.114580285049566 none RPS6KA3_1_111111111 Context-specific genetic dependencies (31) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO741_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-32 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 1.11679627099721 Increased shRNA abundance (Z-score > 2) RPS6KA3_1_111111111 Context-specific genetic dependencies (32) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO783_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-33 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0879047124955249 none RPS6KA3_1_111111111 Context-specific genetic dependencies (33) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CORL23_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-34 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -1.04693589624033 none RPS6KA3_1_111111111 Context-specific genetic dependencies (34) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV362_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-35 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.714795855841465 none RPS6KA3_1_111111111 Context-specific genetic dependencies (35) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV434_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-36 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.148779062725444 none RPS6KA3_1_111111111 Context-specific genetic dependencies (36) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV504_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-37 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.398286554856214 none RPS6KA3_1_111111111 Context-specific genetic dependencies (37) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV644_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-38 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.197287195033722 none RPS6KA3_1_111111111 Context-specific genetic dependencies (38) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DBTRG05MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-39 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.440541850278439 none RPS6KA3_1_111111111 Context-specific genetic dependencies (39) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DKMG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-4 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.537242909569161 none RPS6KA3_1_111111111 Context-specific genetic dependencies (4) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A1207_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-40 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.882278566286525 none RPS6KA3_1_111111111 Context-specific genetic dependencies (40) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DLD1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-41 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0820729161209551 none RPS6KA3_1_111111111 Context-specific genetic dependencies (41) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFE184_ENDOMETRIUM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-42 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.151009887371799 none RPS6KA3_1_111111111 Context-specific genetic dependencies (42) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFM19_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-43 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.777021791802269 none RPS6KA3_1_111111111 Context-specific genetic dependencies (43) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFO21_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-44 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.0468291114070501 none RPS6KA3_1_111111111 Context-specific genetic dependencies (44) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFO27_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-45 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.307552358875214 none RPS6KA3_1_111111111 Context-specific genetic dependencies (45) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EW8_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-46 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.110503176912825 none RPS6KA3_1_111111111 Context-specific genetic dependencies (46) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EWS502_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-47 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.473907910754582 none RPS6KA3_1_111111111 Context-specific genetic dependencies (47) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-48 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.249230634424154 none RPS6KA3_1_111111111 Context-specific genetic dependencies (48) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line GB1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-49 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.268616260902704 none RPS6KA3_1_111111111 Context-specific genetic dependencies (49) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line GP2D_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-5 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.273918009461188 none RPS6KA3_1_111111111 Context-specific genetic dependencies (5) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A172_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-50 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.239869209596892 none RPS6KA3_1_111111111 Context-specific genetic dependencies (50) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1187_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-51 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.423109740665197 none RPS6KA3_1_111111111 Context-specific genetic dependencies (51) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1395_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-52 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.887658132296643 none RPS6KA3_1_111111111 Context-specific genetic dependencies (52) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1954_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-53 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.059817916730566 none RPS6KA3_1_111111111 Context-specific genetic dependencies (53) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC2218_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-54 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.374920658379246 none RPS6KA3_1_111111111 Context-specific genetic dependencies (54) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC2814_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-55 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.883220594468445 none RPS6KA3_1_111111111 Context-specific genetic dependencies (55) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC364_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-56 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.132990090781395 none RPS6KA3_1_111111111 Context-specific genetic dependencies (56) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC44_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-57 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.205138559084784 none RPS6KA3_1_111111111 Context-specific genetic dependencies (57) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC70_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-58 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.24254538930097 none RPS6KA3_1_111111111 Context-specific genetic dependencies (58) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC827GR5_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-59 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0977810123243418 none RPS6KA3_1_111111111 Context-specific genetic dependencies (59) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC827_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-6 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0576486777928243 none RPS6KA3_1_111111111 Context-specific genetic dependencies (6) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A204_SOFT_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-60 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 1.15320079578129 Increased shRNA abundance (Z-score > 2) RPS6KA3_1_111111111 Context-specific genetic dependencies (60) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCT116_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-61 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.476934880365267 none RPS6KA3_1_111111111 Context-specific genetic dependencies (61) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HEC1A_ENDOMETRIUM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-62 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.130738784789826 none RPS6KA3_1_111111111 Context-specific genetic dependencies (62) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HEYA8_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-63 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.537322421448435 none RPS6KA3_1_111111111 Context-specific genetic dependencies (63) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-64 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.135258597380922 none RPS6KA3_1_111111111 Context-specific genetic dependencies (64) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HLF_LIVER shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-65 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.46633610526291 none RPS6KA3_1_111111111 Context-specific genetic dependencies (65) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-66 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.703144877346573 none RPS6KA3_1_111111111 Context-specific genetic dependencies (66) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HPAC_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-67 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.344160505894199 none RPS6KA3_1_111111111 Context-specific genetic dependencies (67) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HPAFII_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-68 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0914267917207103 none RPS6KA3_1_111111111 Context-specific genetic dependencies (68) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS683_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-69 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.0111147436558447 none RPS6KA3_1_111111111 Context-specific genetic dependencies (69) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS766T_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-7 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.055093526140786 none RPS6KA3_1_111111111 Context-specific genetic dependencies (7) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A2058_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-70 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.710978243397359 none RPS6KA3_1_111111111 Context-specific genetic dependencies (70) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS944T_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-71 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.470606885150276 none RPS6KA3_1_111111111 Context-specific genetic dependencies (71) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT1197_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-72 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.800999561776293 none RPS6KA3_1_111111111 Context-specific genetic dependencies (72) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT29_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-73 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.814067795446523 none RPS6KA3_1_111111111 Context-specific genetic dependencies (73) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT55_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-74 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.227833937469788 none RPS6KA3_1_111111111 Context-specific genetic dependencies (74) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HUG1N_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-75 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.0246610104475082 none RPS6KA3_1_111111111 Context-specific genetic dependencies (75) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HUTU80_SMALL_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-76 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.123413461556254 none RPS6KA3_1_111111111 Context-specific genetic dependencies (76) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IGR39_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-77 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.13468441638422 none RPS6KA3_1_111111111 Context-specific genetic dependencies (77) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IGROV1_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-78 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.578449748624658 none RPS6KA3_1_111111111 Context-specific genetic dependencies (78) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IOMMLEE_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-79 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.0532099789077968 none RPS6KA3_1_111111111 Context-specific genetic dependencies (79) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHESOAD1_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-8 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.129342818788632 none RPS6KA3_1_111111111 Context-specific genetic dependencies (8) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A549_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-80 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.479456536121876 none RPS6KA3_1_111111111 Context-specific genetic dependencies (80) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHOC5_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-81 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -1.84838483721219 Decreased shRNA abundance (Z-score < -2) RPS6KA3_1_111111111 Context-specific genetic dependencies (81) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHOM1_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-82 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.673723336954127 none RPS6KA3_1_111111111 Context-specific genetic dependencies (82) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-83 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.164814574313845 none RPS6KA3_1_111111111 Context-specific genetic dependencies (83) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-84 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.190069699213215 none RPS6KA3_1_111111111 Context-specific genetic dependencies (84) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KALS1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-85 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 2.55846831630178 Increased shRNA abundance (Z-score > 2) RPS6KA3_1_111111111 Context-specific genetic dependencies (85) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-86 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.207091960591241 none RPS6KA3_1_111111111 Context-specific genetic dependencies (86) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KM12_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-87 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.584787595989308 none RPS6KA3_1_111111111 Context-specific genetic dependencies (87) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-88 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.0236868876594149 none RPS6KA3_1_111111111 Context-specific genetic dependencies (88) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KNS60_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-89 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.394128429382917 none RPS6KA3_1_111111111 Context-specific genetic dependencies (89) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KNS81_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-9 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.411835016997314 none RPS6KA3_1_111111111 Context-specific genetic dependencies (9) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A673_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-90 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.194929757254295 none RPS6KA3_1_111111111 Context-specific genetic dependencies (90) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP1NL_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-91 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.376964088400517 none RPS6KA3_1_111111111 Context-specific genetic dependencies (91) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP2_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-92 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.16035475515103 none RPS6KA3_1_111111111 Context-specific genetic dependencies (92) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP4_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-93 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.612815759620871 none RPS6KA3_1_111111111 Context-specific genetic dependencies (93) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KURAMOCHI_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-94 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.385571389132727 none RPS6KA3_1_111111111 Context-specific genetic dependencies (94) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE150_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-95 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.633742105111325 none RPS6KA3_1_111111111 Context-specific genetic dependencies (95) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE30_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-96 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.000837946937395915 none RPS6KA3_1_111111111 Context-specific genetic dependencies (96) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE450_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-97 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.21965218992771 none RPS6KA3_1_111111111 Context-specific genetic dependencies (97) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE510_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-98 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 -0.235298328684473 none RPS6KA3_1_111111111 Context-specific genetic dependencies (98) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line L33_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-99 6197 RPS6KA3 TRCN0000001395, TRCN0000001396, TRCN0000001397, TRCN0000001398, TRCN0000010428, TRCN0000040143, TRCN0000040144, TRCN0000040146, TRCN0000288683 0.439299500190601 none RPS6KA3_1_111111111 Context-specific genetic dependencies (99) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
6197 6197 RPS6KA3 -0.06 none
GR00371-A-1 6197 6197 RPS6KA3 -0.380343721735 none Dharmacon Nanog expression in absence of bFGF and TGFbeta Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-2 6197 RPS6KA3 6197 0.488791745343 none Dharmacon Nanog expression in presence of TGFbeta inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-3 6197 6197 RPS6KA3 -0.0654129119326 none Dharmacon Nanog expression in presence of MEK inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-4 6197 6197 RPS6KA3 0.868418879377 none Dharmacon Nanog expression in presence of PI3K inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-5 6197 6197 RPS6KA3 1.00527023346 none Dharmacon Nanog expression in presence of retinoic acid Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00376-A-1 6197 6197 RPS6KA3 0.091999818 none Mitigators of SS1P-induced immunotoxicity Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity Pasetto et al. 2015 25713356 Cell line KB cells Viability Luminescence Ambion Silencer Select Version 4 Genome-wide siRNA RSA P-value <0.001 SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID
GR00376-A-2 6197 6197 RPS6KA3 0.73642181 none Sensitizers of SS1P-induced immunotoxicity Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity Pasetto et al. 2015 25713356 Cell line KB cells Viability Luminescence Ambion Silencer Select Version 4 Genome-wide siRNA RSA P-value <0.001 SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID
GR00378-A 6197 RPS6KA3 -1.683953044 none Poliovirus vaccine production Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game van der Sanden et al. 2015 26581994 Cell line HEp-2C Infection with Attenuated Poliovirus ELISA Dharmacon Genome-wide siRNA Z-score > For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol
6197 NM_004586 RPS6KA3 26.516 none
GR00386-A-1 6197 6197 RPS6KA3 99.200523993085 none NOD2 stimulation by MDP A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. Warner et al. 2014 25170077 Cell line HEK293 stably expressing NOD2 Viability Luminescence Dharmacon Genome-wide siRNA Percentage growth Decreased: <70, increased: >120 Reagent IDs not provided
GR00386-A-2 6197 6197 RPS6KA3 23.5 none MDP-induced IL-8 secretion A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. Warner et al. 2014 25170077 Cell line HEK293 stably expressing NOD2 IL-8 secretion ELISA Dharmacon Genome-wide siRNA Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided