| GR00053-A |
91252 |
NM_152264 |
SLC39A13 |
np |
sp |
none |
|
no |
|
Genome stability |
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. |
Paulsen et al. |
2009 |
19647519 |
Cell line |
HeLa |
gamma-H2AX phosphorylation and DNA content |
Fluorescence |
siARRAY human genome siRNA library |
Genome-wide |
siRNA |
p-value |
Complex criteria |
Confidence groupings from 4 to 1 (highest level of confidence in group 4) |
GR00054-A |
91252 |
NM_152264 |
SLC39A13 |
np |
0.895 |
none |
|
no |
|
Combinatorial effect with paclitaxel |
Synthetic lethal screen identification of chemosensitizer loci in cancer cells. |
Whitehurst et al. |
2007 |
17429401 |
Cell line |
NCI-H1155 |
Viability (synthetic lethal) |
ATP level |
# G-005000-01 |
Genome-wide |
siRNA |
Paclitaxel/control ratio |
Complex criteria |
Additional information about 87 high-confidence hits |
GR00056-A |
91252 |
NM_152264 |
SLC39A13 |
np |
1.119 |
none |
|
no |
|
Melanogenesis |
Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. |
Ganesan et al. |
2008 |
19057677 |
Cell line |
MNT-1 |
Melanin protein expression and viability |
Absorbance and luminescence |
rp |
Genome-wide |
siRNA |
Normalized absorbance ratio |
> 2 standard deviations below mean |
Additional information about a secondary screen (retest to determine false-positive rate) |
GR00057-A-1 |
91252 |
NM_152264 |
SLC39A13 |
M-007568-00 |
0.4 |
none |
|
no |
|
Wnt/beta-catenin pathway regulation (1) |
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. |
Tang et al. |
2008 |
18621708 |
Cell line |
HeLa |
Wnt pathway reporter |
Luminescence |
Human siArray siRNA library |
Genome-wide |
siRNA |
Z-score |
> 4 |
Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries). |
GR00057-A-2 |
91252 |
NM_152264 |
SLC39A13 |
M-007568-00 |
sp |
none |
|
no |
|
Wnt/beta-catenin pathway regulation (2) |
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. |
Tang et al. |
2008 |
18621708 |
Cell line |
HeLa |
Wnt pathway reporter |
Luminescence |
Human siArray siRNA library |
Genome-wide |
siRNA |
Complex, SP |
Complex criteria |
Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries). |
GR00098-A-1 |
91252 |
ENSG00000165915 |
SLC39A13 |
ENSG00000165915 |
sp |
Decreased cell number |
|
yes |
did not validate with resynthesized esiRNA |
Cell division (1) |
Genome-scale RNAi profiling of cell division in human tissue culture cells. |
Kittler et al. |
2007 |
17994010 |
Cell line |
HeLa |
Cell number and DNA content |
Laser scanning cytometry |
rp |
Genome-wide |
esiRNA |
Complex, sp |
Complex criteria |
|
GR00098-A-3 |
91252 |
ENSG00000165915 |
SLC39A13 |
ENSG00000165915 |
0.1 |
none |
|
yes |
|
Cell division (3) |
Genome-scale RNAi profiling of cell division in human tissue culture cells. |
Kittler et al. |
2007 |
17994010 |
Cell line |
HeLa |
Histone H3 phosphorylation; alpha-tubulin and pericentrin protein expression |
Fluorescence |
rp |
Selected genes |
esiRNA |
Mitotic index |
> |
|
GR00098-A-4 |
91252 |
ENSG00000165915 |
SLC39A13 |
ENSG00000165915 |
2.6 |
Increased cell size |
|
no |
|
Cell division (4) |
Genome-scale RNAi profiling of cell division in human tissue culture cells. |
Kittler et al. |
2007 |
17994010 |
Cell line |
HeLa |
Cell size (forward scatter) |
Flow cytometry |
rp |
Selected genes |
esiRNA |
Cell size |
> |
|
GR00151-A-1 |
91252 |
ENSG00000165915 |
SLC39A13 |
np |
-0.294 |
none |
|
no |
|
Homologous recombination DNA double-strand break repair (HR-DSBR) (1) |
A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. |
Słabicki et al. |
2010 |
20613862 |
Cell line |
HeLa |
(HR-DSBR) DR-GFP reporter |
Flow cytometry |
Custom-made |
Genome-wide |
esiRNA |
Z-score |
< -2 OR > 2 |
|
GR00180-A-1 |
91252 |
91252 |
SLC39A13 |
PL-50070 |
0.915 |
none |
|
no |
|
Hepatitis C virus replication (1) |
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. |
Tai et al. |
2009 |
19286138 |
Cell line |
Huh7/Rep-Feo |
HCV replicon RNA copy number |
Luminescence |
siARRAY Human Genome siRNA Library |
Genome-wide |
siRNA |
q-value |
Complex criteria |
|
GR00184-A-1 |
91252 |
NM_152264 |
SLC39A13 |
M-007568-00 |
0.535963214599172 |
none |
|
no |
|
Self-renewal and pluripotency in human embryonic stem cells (1) |
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. |
Chia et al. |
2010 |
20953172 |
Cell line |
hESC H1 |
POU5F1 protein expression |
Fluorescence |
SMARTpool siRNA library |
Genome-wide |
siRNA |
Z-score |
< -2 |
|
GR00196-A-1 |
91252 |
ENSG00000165915 |
|
np |
sp |
none |
|
no |
|
TP53 interactions (1) |
A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. |
Krastev et al. |
2011 |
21642980 |
Cell line |
HCT116 ( wildtype and TP53 knockout) |
TP53 protein expression and viability |
Fluorescence |
rp |
Genome-wide |
esiRNA |
Complex, sp |
Complex criteria |
|
GR00197-A-1 |
91252 |
91252 |
SLC39A13 |
M-007568-00 |
1.308401494 |
none |
|
no |
|
Human papillomavirus oncogene expression regulation (1) |
Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. |
Smith et al. |
2010 |
20133580 |
Cell line |
C33A/BE2/18LCR c4 |
HPV18 LCR reporter activity |
Luminescence |
Human siGENOME SMARTpool library |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5 |
GR00236-A-1 |
91252 |
91252 |
SLC39A13 |
M-007568-00 |
0.910407289135617 |
none |
|
no |
|
Homologous recombination DNA double-strand break repair (HR-DSBR) (1) |
A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. |
Adamson et al. |
2012 |
22344029 |
Cell line |
DR-U2OS |
(HR-DSBR) DR-GFP reporter and DNA content |
Fluorescence |
Human siGENOME siRNA (G-005000-05) |
Genome-wide |
siRNA |
Relative HR ratio |
< ~0.4 OR > 1.88 |
Cutoff values correspond 2 standard deviations from the screen-wide mean |
GR00240-S-1 |
91252 |
NM_152264 |
SLC39A13 |
M-007568-00 |
0.28 |
none |
|
yes |
|
TRAIL-induced apoptosis (1) |
A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. |
Kranz and Boutros |
2014 |
24442637 |
Cell line |
U251MG |
Viability |
Luminescence |
SMART-pool siRNA |
Genome-wide |
siRNA |
Z-score |
> 4 |
Author-submitted data |
GR00240-S-2 |
91252 |
NM_152264 |
SLC39A13 |
M-007568-00 |
-0.43 |
none |
|
no |
Z-score -0.169 |
TRAIL-induced apoptosis (2) |
A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. |
Kranz and Boutros |
2014 |
24442637 |
Cell line |
U251MG |
Viability (synthetic lethal) |
Luminescence |
SMART-pool siRNA |
Genome-wide |
siRNA |
Differential score |
> 3.6 AND viability Z-score < 4 |
Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen. |
GR00242-A-1 |
91252 |
NM_152264 |
SLC39A13 |
np |
sp |
none |
|
no |
|
Selective autophagy regulation (1) |
Image-based genome-wide siRNA screen identifies selective autophagy factors. |
Orvedahl et al. |
2011 |
22020285 |
Cell line |
HeLa/GFP-LC3 |
Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression |
Fluorescence |
siGenome |
Genome-wide |
siRNA |
Z-score |
Complex criteria |
|
GR00247-A-1 |
91252 |
|
SLC39A13 |
np |
sp |
none |
|
|
rank: 9289 |
Regulation of FOXO1 nuclear localization (1) |
Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. |
Senapedis et al. |
2011 |
21460183 |
Cell line |
U2OS |
EGFP-FOXO1a protein expression and DNA content |
Fluorescence |
Human Genome library |
Genome-wide |
siRNA |
Complex, sp |
Complex criteria |
|
GR00249-S |
91252 |
91252 |
SLC39A13 |
J-007568-17 |
0.1133 |
none |
|
no |
number of cells compared to control (%): 81.44 |
Vaccinia virus (VACV) infection |
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. |
Sivan et al. |
2013 |
23401514 |
Cell line |
HeLa |
Vaccinia virus VACV IHD-J/GFP protein expression and DNA content |
Fluorescence |
Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. |
GR00249-S |
91252 |
91252 |
SLC39A13 |
J-007568-17 |
-0.81534 |
none |
|
no |
number of cells compared to control (%): 89.46 |
Vaccinia virus (VACV) infection |
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. |
Sivan et al. |
2013 |
23401514 |
Cell line |
HeLa |
Vaccinia virus VACV IHD-J/GFP protein expression and DNA content |
Fluorescence |
Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. |
GR00249-S |
91252 |
91252 |
SLC39A13 |
M-007568-00 |
-0.31465 |
none |
|
no |
number of cells compared to control (%): 52.96 |
Vaccinia virus (VACV) infection |
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. |
Sivan et al. |
2013 |
23401514 |
Cell line |
HeLa |
Vaccinia virus VACV IHD-J/GFP protein expression and DNA content |
Fluorescence |
Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. |
GR00249-S |
91252 |
91252 |
SLC39A13 |
s40600 |
2.0767 |
Increased vaccinia virus (VACV) infection |
|
no |
number of cells compared to control (%): 82.00 |
Vaccinia virus (VACV) infection |
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. |
Sivan et al. |
2013 |
23401514 |
Cell line |
HeLa |
Vaccinia virus VACV IHD-J/GFP protein expression and DNA content |
Fluorescence |
Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. |
GR00249-S |
91252 |
91252 |
SLC39A13 |
s40601 |
-2.35472 |
Decreased vaccinia virus (VACV) infection |
|
no |
number of cells compared to control (%): 78.37 |
Vaccinia virus (VACV) infection |
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. |
Sivan et al. |
2013 |
23401514 |
Cell line |
HeLa |
Vaccinia virus VACV IHD-J/GFP protein expression and DNA content |
Fluorescence |
Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. |
GR00249-S |
91252 |
91252 |
SLC39A13 |
s40602 |
0.42162 |
none |
|
no |
number of cells compared to control (%): 90.52 |
Vaccinia virus (VACV) infection |
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. |
Sivan et al. |
2013 |
23401514 |
Cell line |
HeLa |
Vaccinia virus VACV IHD-J/GFP protein expression and DNA content |
Fluorescence |
Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. |
GR00253-A |
91252 |
NM_152264 |
SLC39A13 |
np |
-0.408 |
none |
|
|
|
hepcidin regulation |
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. |
Mleczko-Sanecka et al. |
2014 |
24385536 |
Cell line |
Huh7 |
hepcidin::fluc mRNA expression |
Luminescence |
siGenome siARRAY SMARTpool |
Genome-wide |
siRNA |
Z-score |
> |
Cutoff < |
GR00293-A |
91252 |
|
SLC39A13 |
np |
-1.032 |
none |
|
|
|
Combinatorial effect with paclitaxel |
Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death |
Sinnott et al. |
2014 |
24860162 |
Cell line |
HCC366 |
Viability |
Luminescence |
Thermo-Fisher |
Genome-wide |
siRNA |
Z-score |
< -2.5 |
Final hits according to the author are indicated in the comment. |
GR00297-A |
91252 |
|
SLC39A13 |
TRCN0000042845 |
-0.57 |
none |
|
|
|
Glucose limitation response |
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides |
Birsoy et al. |
2014 |
24670634 |
Cell line |
Jurkat |
shRNA abundance in high and low glucose |
Deep sequencing |
TRC |
Selected genes |
shRNA |
Log2 ratio |
< -0.75 |
|
GR00297-A |
91252 |
|
SLC39A13 |
TRCN0000042846 |
0.26 |
none |
|
|
|
Glucose limitation response |
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides |
Birsoy et al. |
2014 |
24670634 |
Cell line |
Jurkat |
shRNA abundance in high and low glucose |
Deep sequencing |
TRC |
Selected genes |
shRNA |
Log2 ratio |
< -0.75 |
|
GR00300-A |
91252 |
|
SLC39A13 |
TRCN0000042844, TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0 |
none |
|
|
|
Combinatorial effect with RAF inhibitor PLX4720 |
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. |
Whittaker et al. |
2013 |
23288408 |
Cell line |
A375 |
shRNA abundance |
Sequencing |
TRC |
Genome-wide |
shRNA |
Number of shRNAs ranked Top1000 |
> 2 |
The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors. |
GR00303-A |
91252 |
NM_152264 |
SLC39A13 |
np |
-0.04 |
none |
|
|
|
Clear cell renal cell carcinoma (ccRCC) survival regulation |
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target |
Gerlinger et al. |
2012 |
22362593 |
Cell line |
VHL-deficient RCC4 |
Proliferation and Viability |
Fluorescence |
np |
Genome-wide |
siRNA |
Z-score |
< |
In the phenotype data duplicates were in the original document, which have been removed. |
|
91252 |
91252 |
SLC39A13 |
M-007568-00 |
-2.971796416091646 |
Decreased interferon-beta reporter expression |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
GR00310-A-1 |
91252 |
91252 |
SLC39A13 |
np |
0.73 |
none |
|
|
|
Sindbis virus (SINV) infection (1) |
Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry |
Ooi et al. |
2013 |
24367265 |
Cell line |
U2OS |
Sindbis virus (SINV) reporter |
Luminescence |
Ambion Silencer V3 |
Genome-wide |
siRNA |
Z-score |
< -3 OR > 2 |
|
|
91252 |
91252 |
SLC39A13 |
np |
21.4 |
none |
|
|
96,7% viability |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
GR00313-A |
91252 |
NM_152264 |
SLC39A13 |
np |
0.22 |
none |
|
|
|
TNF-alpha pathway regulation |
A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. |
Nickles et al. |
2012 |
22733992 |
Cell line |
HEK293T |
NFkappaB pathway reporter |
Luminescence |
Qiagen |
Genome-wide |
siRNA |
Z-score |
< |
Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%. |
GR00343-S |
91252 |
91252 |
SLC39A13 |
TRCN0000042847 |
0.06500000000000128 |
none |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
91252 |
91252 |
SLC39A13 |
TRCN0000042845 |
-0.8800000000000008 |
none |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
91252 |
91252 |
SLC39A13 |
TRCN0000042846 |
0.7599999999999998 |
none |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
91252 |
91252 |
SLC39A13 |
TRCN0000042844 |
0.08000000000000007 |
none |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00363-A |
91252 |
91252 |
SLC39A13 |
SI00724486, SI00724493, SI00724500, 131812, 45726, esi11368, SI00724479 |
sp |
Increased transferrin (TF) endocytosis |
|
|
strong |
Endocytosis regulation |
Systems survey of endocytosis by multiparametric image analysis. |
Collinet et al. |
2010 |
20190736 |
Cell line |
HeLa |
Transferrin (TF) and epidermal growth factor (EGF) subcellular localisation, DNA content |
Fluorescence |
Ambion, Qiagen and esiRNA library (Kittler et al.) |
Genome-wide |
siRNA |
Complex, sp |
Complex criteria |
Two hit categories: "strong" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn > 0.95) and "weak but specific" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn < 0.95 but Phenoscore > 0.95). Additional information about secondary screens with kinase and phospatase libraries. |
GR00366-A-1 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.191238781726184 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (1) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
22RV1_PROSTATE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-10 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.404000732115265 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (10) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
ACHN_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-100 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.192457421700956 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (100) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-101 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.133870515360487 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (101) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LK2_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-102 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.07703554111182 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (102) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN215_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-103 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.07420376837998 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (103) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN229_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-104 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.682434723404723 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (104) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN235_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-105 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.59628086278448 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (105) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN319_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-106 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.688410877463572 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (106) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN340_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-107 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.892602722637848 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (107) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN382_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-108 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.724997501657925 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (108) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN428_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-109 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0966943921697957 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (109) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN443_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-11 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.28780519313004 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (11) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
AGS_STOMACH |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-110 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0598411295254327 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (110) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN464_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-111 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.09309883017199 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (111) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LNZ308_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-112 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.23576973853174 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (112) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LOVO_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-113 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.47509478567978 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (113) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LS411N_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-114 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.3204669951629 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (114) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LS513_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-115 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.72293346685266 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (115) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MCF7_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-116 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.115282176419982 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (116) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MDAMB453_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-117 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.61323053809521 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (117) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MIAPACA2_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-118 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.704867112872194 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (118) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MKN7_STOMACH |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-119 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.223347617312877 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (119) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-12 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0132679639377738 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (12) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
AM38_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-120 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.0297844171222403 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (120) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-121 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.867384669131914 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (121) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-122 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.799883967719967 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (122) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-123 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.563032249959286 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (123) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-124 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.762370383951998 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (124) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-125 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.335091659834697 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (125) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-126 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.20099127082199 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (126) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH1299_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-127 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.09190878290401 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (127) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH1437_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-128 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.73401160658717 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (128) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH1650_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-129 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.99213503339984 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (129) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH1792_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-13 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.371218510891911 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (13) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-130 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.0534049065665852 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (130) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH196_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-131 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.269319351376892 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (131) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH1975_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-132 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.880456394750438 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (132) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH2052_PLEURA |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-133 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.056973644599861 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (133) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH2122_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-134 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.297563385701816 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (134) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH2171_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-135 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.162597169369892 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (135) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH23_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-136 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.24295244449295 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (136) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH2452_PLEURA |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-137 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.819161149596232 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (137) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH441_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-138 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.919801730140272 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (138) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH508_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-139 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.204308761302866 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (139) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH660_PROSTATE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-14 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.41262712027341 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (14) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
ASPC1_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-140 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.892358470107166 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (140) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH661_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-141 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.771394630196952 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (141) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH716_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-142 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0840284435385935 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (142) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH838_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-143 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.18291659999574 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (143) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIN87_STOMACH |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-144 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.777679311580487 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (144) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NIHOVCAR3_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-145 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.09040015722022 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (145) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-146 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
3.61882349994361 |
Increased shRNA abundance (Z-score > 2) |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (146) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OAW42_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-147 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.157790860632477 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (147) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-148 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.48065233762782 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (148) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-149 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.09658364903051 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (149) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-15 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.594222936476631 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (15) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
BT20_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-150 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
2.31640912782255 |
Increased shRNA abundance (Z-score > 2) |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (150) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OE33_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-151 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.564762970314481 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (151) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OELE_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-152 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.440163584891365 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (152) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-153 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.71898459412348 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (153) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OV7_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-154 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.907400828806715 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (154) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OV90_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-155 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.617707377927882 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (155) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OVCAR4_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-156 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.150051254212165 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (156) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OVCAR8_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-157 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.59009808739952 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (157) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OVISE_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-158 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.670030518876325 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (158) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
PANC0327_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-159 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.394187206961592 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (159) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
PANC0813_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-16 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.749107106327491 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (16) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
BT474_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-160 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.376058122178515 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (160) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
PANC1005_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-161 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.786172358769332 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (161) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-162 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.193543290483425 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (162) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
PSN1_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-163 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.188991176381834 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (163) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
QGP1_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-164 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0902668561994204 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (164) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-165 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.0779232568332252 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (165) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
RKN_SOFT_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-166 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.10581638796051 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (166) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
RKO_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-167 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.69090810057245 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (167) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
RMGI_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-168 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.675459958973256 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (168) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
RMUGS_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-169 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.381522193994368 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (169) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-17 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.829216812382463 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (17) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
BXPC3_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-170 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.346658265260559 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (170) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
RT112_URINARY_TRACT |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-171 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.486557264896525 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (171) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-172 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.527134473642324 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (172) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SF126_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-173 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.58882355869401 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (173) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SF172_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-174 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.05727258202316 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (174) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SF295_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-175 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.222582120293174 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (175) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SF767_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-176 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.904370927091656 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (176) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SJSA1_BONE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-177 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.234128906869765 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (177) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SKCO1_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-178 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.187725055152754 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (178) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SKMEL5_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-179 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.687378284574648 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (179) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-18 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.133076024158729 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (18) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
C2BBE1_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-180 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.19078731021066 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (180) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-181 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.90270075292501 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (181) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SKOV3_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-182 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.836538997265114 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (182) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SKRC20_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-183 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.200359341109175 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (183) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SLR20_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-184 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.81280967422074 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (184) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SLR21_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-185 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.732656661031487 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (185) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SLR23_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-186 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.318673316753572 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (186) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SLR24_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-187 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.412409702656302 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (187) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SLR25_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-188 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.22352652401265 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (188) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SLR26_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-189 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0268413161547903 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (189) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SNU1105_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-19 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
2.20249221743121 |
Increased shRNA abundance (Z-score > 2) |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (19) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
C32_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-190 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.219689427075098 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (190) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SNU840_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-191 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.352203939979127 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (191) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SNUC1_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-192 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.588014287042874 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (192) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SNUC2A_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-193 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.273950965918725 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (193) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SU8686_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-194 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.39422384680516 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (194) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SW1417_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-195 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.302905246561264 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (195) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SW1783_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-196 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.799944466678953 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (196) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SW480_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-197 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.445486779316928 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (197) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SW48_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-198 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.842265178717667 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (198) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
T98G_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-199 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.468501588581348 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (199) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TC71_BONE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-2 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.996495069332767 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (2) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-20 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.852716389184376 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (20) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CADOES1_BONE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-200 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.67093198633641 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (200) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TCCSUP_URINARY_TRACT |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-201 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.25268199041569 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (201) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TE10_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-202 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.35937428925804 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (202) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TE15_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-203 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.643314097626811 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (203) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TE9_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-204 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.813714035273073 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (204) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-205 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.778878130897627 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (205) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TOV112D_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-206 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.11043321989188 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (206) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TOV21G_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-207 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.128403071598242 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (207) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TT_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-208 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.335749167182966 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (208) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TYKNU_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-209 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.992727409409733 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (209) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
U178_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-21 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.53433074134645 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (21) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CAL120_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-210 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.19468014216978 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (210) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
U251MG_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-211 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.126147136197853 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (211) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
U343_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-212 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.0217494102185305 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (212) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
U87MG_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-213 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
2.72334183540764 |
Increased shRNA abundance (Z-score > 2) |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (213) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
UOK101_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-214 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-2.16683872571359 |
Decreased shRNA abundance (Z-score < -2) |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (214) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
VCAP_PROSTATE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-215 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.513393213805389 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (215) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
YKG1_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-216 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.00443795435117229 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (216) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
ZR7530_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-22 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.213466822223217 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (22) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CAL51_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-23 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.11252469796145 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (23) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CALU1_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-24 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.382724483932631 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (24) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CAOV3_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-25 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.55114317845811 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (25) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CAOV4_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-26 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.24404035105172 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (26) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CAS1_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-27 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.669777096299831 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (27) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CFPAC1_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-28 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.8317331738059 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (28) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CH157MN_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-29 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0575055969248247 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (29) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COLO205_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-3 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.343043081575688 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (3) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
786O_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-30 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.271923881033234 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (30) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COLO704_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-31 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.120215668861418 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (31) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COLO741_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-32 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.1825992657459 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (32) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COLO783_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-33 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.954255847952946 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (33) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CORL23_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-34 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.814670599459522 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (34) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COV362_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-35 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.29572372788556 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (35) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COV434_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-36 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.650945275492235 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (36) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COV504_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-37 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0596208457450515 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (37) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COV644_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-38 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.0380208163088 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (38) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
DBTRG05MG_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-39 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0953977859610017 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (39) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
DKMG_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-4 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.0256938771417956 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (4) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
A1207_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-40 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.40054002408494 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (40) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
DLD1_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-41 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.52636574269212 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (41) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
EFE184_ENDOMETRIUM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-42 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.60462036472317 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (42) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
EFM19_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-43 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
4.3158565476885 |
Increased shRNA abundance (Z-score > 2) |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (43) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
EFO21_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-44 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.257591951445141 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (44) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
EFO27_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-45 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.811872542541813 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (45) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
EW8_BONE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-46 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.435977984054602 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (46) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
EWS502_BONE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-47 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.55413219486923 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (47) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-48 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.652759785630964 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (48) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
GB1_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-49 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.175083922762359 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (49) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
GP2D_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-5 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.222788439243819 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (5) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
A172_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-50 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
2.46850590203884 |
Increased shRNA abundance (Z-score > 2) |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (50) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC1187_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-51 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.429622064263329 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (51) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC1395_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-52 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.726310726633284 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (52) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC1954_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-53 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.67715943479528 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (53) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC2218_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-54 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.3236995114529 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (54) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC2814_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-55 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.594820980651059 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (55) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC364_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-56 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.73446318226158 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (56) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC44_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-57 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.184708755531626 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (57) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC70_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-58 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0670466411855997 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (58) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC827GR5_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-59 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0513598750536372 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (59) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC827_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-6 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.163554618911808 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (6) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
A204_SOFT_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-60 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.154458193281559 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (60) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCT116_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-61 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.0586718197292065 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (61) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HEC1A_ENDOMETRIUM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-62 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.235776717281566 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (62) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HEYA8_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-63 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.0918520450969748 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (63) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-64 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.546669646845742 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (64) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HLF_LIVER |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-65 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.765744135398083 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (65) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-66 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.509507787192756 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (66) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HPAC_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-67 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.193112751406884 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (67) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HPAFII_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-68 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0963887070037781 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (68) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HS683_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-69 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.672733857515555 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (69) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HS766T_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-7 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.49445359128346 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (7) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
A2058_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-70 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.235219570178235 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (70) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HS944T_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-71 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.27857699122694 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (71) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HT1197_URINARY_TRACT |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-72 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0500186744658134 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (72) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HT29_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-73 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.64632578470438 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (73) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HT55_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-74 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.437115207231053 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (74) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HUG1N_STOMACH |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-75 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.17749157775252 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (75) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HUTU80_SMALL_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-76 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.152088769722831 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (76) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
IGR39_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-77 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
2.04066365708413 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (77) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
IGROV1_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-78 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.256182829106083 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (78) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
IOMMLEE_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-79 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.0490109337678206 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (79) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
JHESOAD1_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-8 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.862328001784793 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (8) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
A549_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-80 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.30334436250278 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (80) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
JHOC5_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-81 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
2.1686136762067 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (81) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
JHOM1_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-82 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.383128548613669 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (82) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-83 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.21687560809284 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (83) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-84 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.0608137366746754 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (84) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KALS1_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-85 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.37835536306482 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (85) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-86 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.82895892069866 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (86) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KM12_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-87 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.31198697040095 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (87) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-88 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
1.45750912948135 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (88) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KNS60_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-89 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.09157867526033 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (89) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KNS81_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-9 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.346809281254156 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (9) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
A673_BONE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-90 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.471523459243298 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (90) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KP1NL_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-91 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.0814330702905524 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (91) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KP2_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-92 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.516450046361339 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (92) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KP4_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-93 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.515394054388093 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (93) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KURAMOCHI_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-94 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.307496235906276 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (94) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KYSE150_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-95 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.421844066111286 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (95) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KYSE30_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-96 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-1.18777486708079 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (96) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KYSE450_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-97 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.872042057954148 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (97) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KYSE510_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-98 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
-0.206527030282243 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (98) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
L33_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-99 |
91252 |
|
SLC39A13 |
TRCN0000042845, TRCN0000042846, TRCN0000042847 |
0.61642785146593 |
none |
|
|
SLC39A13_1_111 |
Context-specific genetic dependencies (99) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00368-A |
91252 |
91252 |
SLC39A13 |
|
0.82 |
Decreased viability ratio |
|
|
wt viability: 0,76 |
Combinatorial effect with E-Cadherin |
Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin–Deficient Cells |
Telford et al. |
2015 |
25777964 |
Cell line |
MCF10A |
Viability (synthetic lethal) |
Luminescence |
Dharmacon |
Genome-wide |
siRNA |
CDH1(-/-)/wt viability ratio |
< |
MCF10A wild type viability higher-or-equal to 50% was considered as additional cutoff (values noted in "comment" section). |
|
91252 |
91252 |
SLC39A13 |
|
0.010000000000000002 |
none |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
GR00376-A-1 |
91252 |
91252 |
SLC39A13 |
|
0.747558355 |
none |
|
|
|
Mitigators of SS1P-induced immunotoxicity |
Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity |
Pasetto et al. |
2015 |
25713356 |
Cell line |
KB cells |
Viability |
Luminescence |
Ambion Silencer Select Version 4 |
Genome-wide |
siRNA |
RSA P-value |
<0.001 |
SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID |
GR00376-A-2 |
91252 |
91252 |
SLC39A13 |
|
0.048047956 |
none |
|
|
|
Sensitizers of SS1P-induced immunotoxicity |
Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity |
Pasetto et al. |
2015 |
25713356 |
Cell line |
KB cells |
Viability |
Luminescence |
Ambion Silencer Select Version 4 |
Genome-wide |
siRNA |
RSA P-value |
<0.001 |
SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID |
GR00378-A |
91252 |
|
SLC39A13 |
|
-0.397446582 |
none |
|
|
|
Poliovirus vaccine production |
Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game |
van der Sanden et al. |
2015 |
26581994 |
Cell line |
HEp-2C |
Infection with Attenuated Poliovirus |
ELISA |
Dharmacon |
Genome-wide |
siRNA |
Z-score |
> |
For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol |
|
91252 |
NM_152264 |
SLC39A13 |
|
24.325 |
Decreased viability |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
GR00386-A-1 |
91252 |
91252 |
SLC39A13 |
|
97.5544279225142 |
none |
|
|
|
NOD2 stimulation by MDP |
A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. |
Warner et al. |
2014 |
25170077 |
Cell line |
HEK293 stably expressing NOD2 |
Viability |
Luminescence |
Dharmacon |
Genome-wide |
siRNA |
Percentage growth |
Decreased: <70, increased: >120 |
Reagent IDs not provided |
GR00386-A-2 |
91252 |
91252 |
SLC39A13 |
|
-5.4 |
none |
|
|
|
MDP-induced IL-8 secretion |
A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. |
Warner et al. |
2014 |
25170077 |
Cell line |
HEK293 stably expressing NOD2 |
IL-8 secretion |
ELISA |
Dharmacon |
Genome-wide |
siRNA |
Percent inhibition of IL-8 secretion |
Increased: <-300, Decreased: >60 |
Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided |