Gene Ontology

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 10221
• Symbol: TRIB1
• Description: tribbles pseudokinase 1

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
10221	GO:0004860	IMP	enables	protein kinase inhibitor activity	15299019	Function
10221	GO:0005515	IPI	enables	protein binding	25852190,28514442,32707033	Function
10221	GO:0031434	IDA	enables	mitogen-activated protein kinase kinase binding	15299019,17452330	Function
10221	GO:0061629	IPI	enables	RNA polymerase II-specific DNA-binding transcription factor binding	17724128	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
10221	GO:0005634	IDA	located_in	nucleus	17452330	Component
10221	GO:0005737	IDA	located_in	cytoplasm	17452330	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
10221	GO:0006469	IMP	involved_in	negative regulation of protein kinase activity	15299019	Process
10221	GO:0007254	IMP	involved_in	JNK cascade	17452330	Process
10221	GO:0014912	IMP	involved_in	negative regulation of smooth muscle cell migration	17452330	Process
10221	GO:0031665	IMP	involved_in	negative regulation of lipopolysaccharide-mediated signaling pathway	17452330	Process
10221	GO:0032496	IMP	involved_in	response to lipopolysaccharide	17452330	Process
10221	GO:0043405	IDA	involved_in	regulation of MAP kinase activity	15299019	Process
10221	GO:0043433	IMP	involved_in	negative regulation of DNA-binding transcription factor activity	15299019	Process
10221	GO:0048662	IMP	involved_in	negative regulation of smooth muscle cell proliferation	17452330	Process