Gene Ontology

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 1026
• Symbol: CDKN1A
• Description: cyclin dependent kinase inhibitor 1A

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
1026	GO:0000307	IDA	part_of	cyclin-dependent protein kinase holoenzyme complex	17420273	Component
1026	GO:0005634	IDA	located_in	nucleus	11343236,23213251	Component
1026	GO:0005654	IDA	located_in	nucleoplasm	22869755	Component
1026	GO:0005730	IDA	located_in	nucleolus	22869755	Component
1026	GO:0016604	IDA	located_in	nuclear body		Component
1026	GO:0032991	IDA	part_of	protein-containing complex	22869755	Component
1026	GO:0070557	IDA	part_of	PCNA-p21 complex	18794347	Component
1026	GO:0070557	IMP	part_of	PCNA-p21 complex	11595739	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
1026	GO:0001933	IEP	involved_in	negative regulation of protein phosphorylation	7958916	Process
1026	GO:0001934	IEP	involved_in	positive regulation of protein phosphorylation	22869755	Process
1026	GO:0006974	IMP	involved_in	DNA damage response	20160708	Process
1026	GO:0006977	IDA	involved_in	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	15149599	Process
1026	GO:0007095	IMP	involved_in	mitotic G2 DNA damage checkpoint signaling	23213251	Process
1026	GO:0007265	IEP	involved_in	Ras protein signal transduction	9054499	Process
1026	GO:0008285	IDA	involved_in	negative regulation of cell population proliferation	10208428,15149599	Process
1026	GO:0008285	IMP	involved_in	negative regulation of cell population proliferation	17553787,18850004	Process
1026	GO:0010389	IMP	involved_in	regulation of G2/M transition of mitotic cell cycle	17553787	Process
1026	GO:0030308	IDA	involved_in	negative regulation of cell growth	10208428	Process
1026	GO:0031668	IMP	involved_in	cellular response to extracellular stimulus	17553787	Process
1026	GO:0032091	IMP	involved_in	negative regulation of protein binding	11595739	Process
1026	GO:0034198	IMP	involved_in	cellular response to amino acid starvation	26102367	Process
1026	GO:0042326	IDA	involved_in	negative regulation of phosphorylation	10208428	Process
1026	GO:0045860	IDA	acts_upstream_of_or_within	positive regulation of protein kinase activity	22869755	Process
1026	GO:0048146	IMP	involved_in	positive regulation of fibroblast proliferation	17420273	Process
1026	GO:0051726	IDA	involved_in	regulation of cell cycle	15149599	Process
1026	GO:0051726	IMP	involved_in	regulation of cell cycle	26102367	Process
1026	GO:0071479	IMP	involved_in	cellular response to ionizing radiation	20160708	Process
1026	GO:0090398	IMP	involved_in	cellular senescence	15149599,17553787	Process
1026	GO:1902806	IMP	involved_in	regulation of cell cycle G1/S phase transition	23213251	Process
1026	GO:1904030	IMP	involved_in	negative regulation of cyclin-dependent protein kinase activity	8876165	Process
1026	GO:1904706	IMP	involved_in	negative regulation of vascular associated smooth muscle cell proliferation	25681685	Process
1026	GO:2000045	IDA	involved_in	regulation of G1/S transition of mitotic cell cycle	10208428	Process
1026	GO:2000134	IGI	acts_upstream_of_or_within	negative regulation of G1/S transition of mitotic cell cycle	21628527	Process
1026	GO:2000279	IMP	involved_in	negative regulation of DNA biosynthetic process	11595739	Process
1026	GO:2000379	IMP	involved_in	positive regulation of reactive oxygen species metabolic process	20160708	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
1026	GO:0004860	IMP	enables	protein kinase inhibitor activity	8876165	Function
1026	GO:0005515	IPI	enables	protein binding	8756624,8861913,9106657,9840943,10873631,15232106,15576034,156.....	Function
1026	GO:0019901	IPI	enables	protein kinase binding	8876165	Function
1026	GO:0019912	IDA	enables	cyclin-dependent protein kinase activating kinase activity	9106657	Function
1026	GO:0031625	IPI	enables	ubiquitin protein ligase binding	23026136	Function
1026	GO:0044877	IPI	enables	protein-containing complex binding	8876165	Function
1026	GO:0140311	EXP	enables	protein sequestering activity	11595739	Function
1026	GO:0140311	IMP	enables	protein sequestering activity	11595739	Function
1026	GO:0140677	IMP	enables	molecular function activator activity	17553787	Function
1026	GO:0140678	IDA	enables	molecular function inhibitor activity	8876165	Function