Gene Ontology

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 10577
• Symbol: NPC2
• Description: NPC intracellular cholesterol transporter 2

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
10577	GO:0005515	IPI	enables	protein binding	19664597,20674861,22095670,27238017,27940359	Function
10577	GO:0015485	IDA	enables	cholesterol binding	17018531,18772377,27238017	Function
10577	GO:0019899	IPI	enables	enzyme binding	15110773	Function
10577	GO:0120020	IDA	enables	cholesterol transfer activity	18772377,25339683,27238017	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
10577	GO:0005615	IMP	located_in	extracellular space	15937921	Component
10577	GO:0005764	IDA	is_active_in	lysosome	25339683	Component
10577	GO:0005764	IDA	located_in	lysosome	11125141,15937921	Component
10577	GO:0070062	HDA	located_in	extracellular exosome	23533145	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
10577	GO:0009615	IEP	involved_in	response to virus	16548883	Process
10577	GO:0030301	IDA	involved_in	cholesterol transport	17018531,18772377	Process
10577	GO:0032366	IDA	involved_in	intracellular sterol transport	17018531	Process
10577	GO:0032367	IDA	involved_in	intracellular cholesterol transport	17018531,18823126	Process
10577	GO:0032367	IGI	acts_upstream_of_or_within	intracellular cholesterol transport	19723497	Process
10577	GO:0032367	IMP	involved_in	intracellular cholesterol transport	15937921,27238017	Process
10577	GO:0033344	IDA	involved_in	cholesterol efflux	16141411,25339683	Process
10577	GO:0042632	IDA	involved_in	cholesterol homeostasis	12719428	Process
10577	GO:0042632	IMP	involved_in	cholesterol homeostasis	15937921	Process