Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 1080
  • Symbol: CFTR
  • Description: CF transmembrane conductance regulator

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1080 GO:0005254 IDA enables chloride channel activity 11524016,11707463,15010471,18570918,19019741,22178883..... Function
1080 GO:0005254 IMP enables chloride channel activity 19621064,24885604 Function
1080 GO:0005260 IMP enables intracellularly ATP-gated chloride channel activity 8910473 Function
1080 GO:0005515 IPI enables protein binding 9671706,9792704,11707463,12369822,12471024,15247260,16203867,1..... Function
1080 GO:0015106 IDA enables bicarbonate transmembrane transporter activity 15010471,19019741 Function
1080 GO:0016887 IDA enables ATP hydrolysis activity 8910473,11524016 Function
1080 GO:0019869 IDA enables chloride channel inhibitor activity 22178883 Function
1080 GO:0019899 IPI enables enzyme binding 19398555 Function
1080 GO:0030165 IDA enables PDZ domain binding 11707463 Function
1080 GO:0051087 IPI enables protein-folding chaperone binding 16207813 Function
1080 GO:0106138 IDA enables Sec61 translocon complex binding 9792704 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1080 GO:0005737 IDA located_in cytoplasm 18570918 Component
1080 GO:0005769 IDA located_in early endosome 19398555 Component
1080 GO:0005789 IDA located_in endoplasmic reticulum membrane 11707463 Component
1080 GO:0005829 IDA located_in cytosol 24885604 Component
1080 GO:0005886 IDA located_in plasma membrane 11524016,15010471,21884936,22178883,24885604,28067262,28130590..... Component
1080 GO:0005886 IMP located_in plasma membrane 11707463 Component
1080 GO:0009986 IDA located_in cell surface 20658517 Component
1080 GO:0016020 IDA located_in membrane 8910473 Component
1080 GO:0016324 IDA located_in apical plasma membrane 12801959,15247260,18570918,20658517,28130590,32487539..... Component
1080 GO:0016324 IMP located_in apical plasma membrane 19621064 Component
1080 GO:0032991 IDA part_of protein-containing complex 17462998 Component
1080 GO:0055037 IDA located_in recycling endosome 18570918 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1080 GO:0015701 IDA involved_in bicarbonate transport 15010471,19019741 Process
1080 GO:0034976 IDA involved_in response to endoplasmic reticulum stress 21884936,28067262 Process
1080 GO:0035377 IMP involved_in transepithelial water transport 19621064 Process
1080 GO:0035774 IGI involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus 24885604 Process
1080 GO:0035774 IMP involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus 24885604 Process
1080 GO:0045921 IMP involved_in positive regulation of exocytosis 24885604 Process
1080 GO:0050891 IMP involved_in multicellular organismal-level water homeostasis 19621064 Process
1080 GO:1902161 IMP involved_in positive regulation of cyclic nucleotide-gated ion channel activity 24885604 Process
1080 GO:1902476 IDA involved_in chloride transmembrane transport 11524016,11707463,19019741 Process
1080 GO:1902476 IMP involved_in chloride transmembrane transport 19621064,24885604 Process
1080 GO:1902943 IDA involved_in positive regulation of voltage-gated chloride channel activity 22006324 Process
1080 GO:1904322 IDA involved_in cellular response to forskolin 15010471,19621064 Process