Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 10979
  • Symbol: FERMT2
  • Description: FERM domain containing kindlin 2

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
10979 GO:0003779 IMP enables actin binding 29496737 Function
10979 GO:0005515 IPI enables protein binding 22699938 Function
10979 GO:0005547 IDA enables phosphatidylinositol-3,4,5-trisphosphate binding 21325030,22030399 Function
10979 GO:0019901 IPI enables protein kinase binding 30254023 Function
10979 GO:0034713 IPI enables type I transforming growth factor beta receptor binding 23723426 Function
10979 GO:0046332 IPI enables SMAD binding 23723426 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
10979 GO:0005634 IDA located_in nucleus 22699938 Component
10979 GO:0005654 IDA located_in nucleoplasm Component
10979 GO:0005737 IDA located_in cytoplasm 18528435,22699938,28799653 Component
10979 GO:0005829 IDA located_in cytosol 23723426 Component
10979 GO:0005886 IDA located_in plasma membrane 23723426,30382829 Component
10979 GO:0005912 IDA located_in adherens junction 28799653 Component
10979 GO:0005925 HDA located_in focal adhesion 21423176 Component
10979 GO:0005925 IDA located_in focal adhesion 18528435,21325030,29162887,29496737 Component
10979 GO:0009898 IDA located_in cytoplasmic side of plasma membrane 21325030 Component
10979 GO:0030054 IDA located_in cell junction 30382829 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
10979 GO:0007155 IGI acts_upstream_of_or_within cell adhesion 21356350 Process
10979 GO:0007155 IMP acts_upstream_of_or_within cell adhesion 30382829 Process
10979 GO:0007160 IMP involved_in cell-matrix adhesion 21325030 Process
10979 GO:0007179 IMP involved_in transforming growth factor beta receptor signaling pathway 21325030 Process
10979 GO:0007229 IMP involved_in integrin-mediated signaling pathway 21325030 Process
10979 GO:0010718 IDA involved_in positive regulation of epithelial to mesenchymal transition 24226523 Process
10979 GO:0016055 IMP involved_in Wnt signaling pathway 22699938 Process
10979 GO:0022604 IMP involved_in regulation of cell morphogenesis 30254023 Process
10979 GO:0030335 IMP involved_in positive regulation of cell migration 30382829 Process
10979 GO:0033622 IMP involved_in integrin activation 22030399 Process
10979 GO:0033625 IGI involved_in positive regulation of integrin activation 21356350 Process
10979 GO:0034334 IMP involved_in adherens junction maintenance 28799653 Process
10979 GO:0035505 IMP involved_in positive regulation of myosin light chain kinase activity 29496737 Process
10979 GO:0043116 IMP involved_in negative regulation of vascular permeability 28799653 Process
10979 GO:0043547 IMP involved_in positive regulation of GTPase activity 29496737 Process
10979 GO:0045599 IMP involved_in negative regulation of fat cell differentiation 29496737 Process
10979 GO:0045669 IMP involved_in positive regulation of osteoblast differentiation 29496737 Process
10979 GO:0048041 IMP involved_in focal adhesion assembly 21356350 Process
10979 GO:0051496 IMP involved_in positive regulation of stress fiber assembly 29496737 Process
10979 GO:0051894 IMP involved_in positive regulation of focal adhesion assembly 29496737 Process
10979 GO:0051897 IDA involved_in positive regulation of protein kinase B signaling 24226523 Process
10979 GO:0070374 IDA involved_in positive regulation of ERK1 and ERK2 cascade 24226523 Process
10979 GO:1900026 IGI involved_in positive regulation of substrate adhesion-dependent cell spreading 30254023 Process
10979 GO:1900182 IDA involved_in positive regulation of protein localization to nucleus 23723426 Process
10979 GO:1902414 IMP acts_upstream_of_or_within protein localization to cell junction 30254023 Process
10979 GO:1902462 IMP involved_in positive regulation of mesenchymal stem cell proliferation 29496737 Process
10979 GO:1903691 IMP involved_in positive regulation of wound healing, spreading of epidermal cells 21356350 Process