Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 11315
  • Symbol: PARK7
  • Description: Parkinsonism associated deglycase

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
11315 GO:0000785 IDA part_of chromatin 16731528 Component
11315 GO:0005634 HDA located_in nucleus 21630459 Component
11315 GO:0005634 IDA located_in nucleus 11477070,12446870,14662519,15790595,15983381,18711745,19822128..... Component
11315 GO:0005654 IDA located_in nucleoplasm Component
11315 GO:0005737 IDA located_in cytoplasm 12446870,15983381,17510388,18711745,19822128 Component
11315 GO:0005739 IDA located_in mitochondrion 15790595,15944198,18711745,19229105,19822128,23743200,31536960..... Component
11315 GO:0005739 IMP located_in mitochondrion 21785459 Component
11315 GO:0005783 IDA located_in endoplasmic reticulum 31536960 Component
11315 GO:0005829 IDA located_in cytosol 14662519,15944198,19229105,22683601 Component
11315 GO:0005829 IMP located_in cytosol 21785459 Component
11315 GO:0005912 HDA located_in adherens junction 25468996 Component
11315 GO:0016605 IDA located_in PML body 22683601 Component
11315 GO:0048471 IDA located_in perinuclear region of cytoplasm 25468996 Component
11315 GO:0070062 HDA located_in extracellular exosome 19056867,19199708,20458337,23533145 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
11315 GO:0001933 IGI involved_in negative regulation of protein phosphorylation 15983381 Process
11315 GO:0006281 IDA involved_in DNA repair 28596309 Process
11315 GO:0006469 IGI involved_in negative regulation of protein kinase activity 15983381 Process
11315 GO:0006517 IDA NOT involved_in protein deglycosylation 27903648 Process
11315 GO:0006517 IDA involved_in protein deglycosylation 25416785 Process
11315 GO:0006517 IMP involved_in protein deglycosylation 26995087,30894531 Process
11315 GO:0009438 IDA NOT involved_in methylglyoxal metabolic process 27903648 Process
11315 GO:0009438 IDA involved_in methylglyoxal metabolic process 22523093 Process
11315 GO:0010273 IMP involved_in detoxification of copper ion 23792957 Process
11315 GO:0010629 IDA involved_in negative regulation of gene expression 22683601 Process
11315 GO:0019249 IDA involved_in lactate biosynthetic process 22523093 Process
11315 GO:0031334 IDA involved_in positive regulation of protein-containing complex assembly 24947010 Process
11315 GO:0031397 IDA involved_in negative regulation of protein ubiquitination 17015834,24899725 Process
11315 GO:0032091 IDA involved_in negative regulation of protein binding 11477070,16731528,17015834,24899725 Process
11315 GO:0032091 IGI involved_in negative regulation of protein binding 15983381 Process
11315 GO:0032091 IMP involved_in negative regulation of protein binding 21785459 Process
11315 GO:0032435 IDA involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process 17015834 Process
11315 GO:0032679 IMP NOT involved_in regulation of TRAIL production 21785459 Process
11315 GO:0032757 IDA involved_in positive regulation of interleukin-8 production 21097510 Process
11315 GO:0033138 IMP involved_in positive regulation of peptidyl-serine phosphorylation 22492997 Process
11315 GO:0033234 IDA involved_in negative regulation of protein sumoylation 16731528 Process
11315 GO:0034599 IDA involved_in cellular response to oxidative stress 15983381,19703902,20969476,22683601 Process
11315 GO:0034599 IMP involved_in cellular response to oxidative stress 24899725 Process
11315 GO:0036471 IDA involved_in cellular response to glyoxal 22523093 Process
11315 GO:0036526 IDA involved_in peptidyl-cysteine deglycation 25416785 Process
11315 GO:0036527 IDA involved_in peptidyl-arginine deglycation 25416785 Process
11315 GO:0036527 IMP involved_in peptidyl-arginine deglycation 30150385 Process
11315 GO:0036528 IDA involved_in peptidyl-lysine deglycation 25416785 Process
11315 GO:0036529 IDA involved_in protein deglycation, glyoxal removal 25416785 Process
11315 GO:0036530 IDA NOT involved_in protein deglycation, methylglyoxal removal 27903648 Process
11315 GO:0036530 IDA involved_in protein deglycation, methylglyoxal removal 25416785 Process
11315 GO:0036530 IMP involved_in protein deglycation, methylglyoxal removal 30150385 Process
11315 GO:0036531 IDA involved_in glutathione deglycation 25416785 Process
11315 GO:0042743 IDA involved_in hydrogen peroxide metabolic process 24567322 Process
11315 GO:0043523 IDA involved_in regulation of neuron apoptotic process 18711745,20304780 Process
11315 GO:0043524 IDA involved_in negative regulation of neuron apoptotic process 22511790 Process
11315 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 21097510 Process
11315 GO:0045944 IGI involved_in positive regulation of transcription by RNA polymerase II 15790595,17015834 Process
11315 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 16731528,19703902,22492997 Process
11315 GO:0046295 IDA involved_in glycolate biosynthetic process 22523093 Process
11315 GO:0046826 IGI involved_in negative regulation of protein export from nucleus 15983381 Process
11315 GO:0050787 IMP involved_in detoxification of mercury ion 23792957 Process
11315 GO:0050821 IDA involved_in protein stabilization 24947010 Process
11315 GO:0050821 IMP involved_in protein stabilization 17015834,19229105 Process
11315 GO:0051091 IMP involved_in positive regulation of DNA-binding transcription factor activity 17015834 Process
11315 GO:0051444 IDA involved_in negative regulation of ubiquitin-protein transferase activity 24899725 Process
11315 GO:0051881 IMP involved_in regulation of mitochondrial membrane potential 23743200 Process
11315 GO:0060765 IDA involved_in regulation of androgen receptor signaling pathway 11477070 Process
11315 GO:0061691 IDA involved_in detoxification of hydrogen peroxide 14749723 Process
11315 GO:0061727 IDA involved_in methylglyoxal catabolic process to lactate 28993701 Process
11315 GO:0070301 IMP involved_in cellular response to hydrogen peroxide 22492997 Process
11315 GO:0106044 IDA involved_in guanine deglycation 28596309 Process
11315 GO:0106045 IDA involved_in guanine deglycation, methylglyoxal removal 28596309 Process
11315 GO:0106046 IDA involved_in guanine deglycation, glyoxal removal 28596309 Process
11315 GO:0110095 IDA involved_in cellular detoxification of aldehyde 28993701 Process
11315 GO:0140041 IDA involved_in cellular detoxification of methylglyoxal 28993701 Process
11315 GO:1900182 IDA involved_in positive regulation of protein localization to nucleus 21097510 Process
11315 GO:1900182 IMP involved_in positive regulation of protein localization to nucleus 22492997 Process
11315 GO:1901215 IDA involved_in negative regulation of neuron death 22683601 Process
11315 GO:1901671 IDA involved_in positive regulation of superoxide dismutase activity 24567322 Process
11315 GO:1901984 IDA involved_in negative regulation of protein acetylation 22683601 Process
11315 GO:1902176 IDA acts_upstream_of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 22523093 Process
11315 GO:1902236 IGI involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 14652021 Process
11315 GO:1902958 IMP involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone 19822128 Process
11315 GO:1903094 IDA involved_in negative regulation of protein K48-linked deubiquitination 21097510 Process
11315 GO:1903122 IMP involved_in negative regulation of TRAIL-activated apoptotic signaling pathway 21785459 Process
11315 GO:1903168 IDA involved_in positive regulation of pyrroline-5-carboxylate reductase activity 23743200 Process
11315 GO:1903178 IDA involved_in positive regulation of tyrosine 3-monooxygenase activity 19703902 Process
11315 GO:1903181 IDA involved_in positive regulation of dopamine biosynthetic process 19703902 Process
11315 GO:1903189 IDA involved_in glyoxal metabolic process 22523093 Process
11315 GO:1903197 IMP involved_in positive regulation of L-dopa biosynthetic process 16731528 Process
11315 GO:1903200 IDA involved_in positive regulation of L-dopa decarboxylase activity 19703902 Process
11315 GO:1903376 IDA involved_in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 15983381 Process
11315 GO:1903377 IDA involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 15790595,16632486 Process
11315 GO:1903377 IMP involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 23743200 Process
11315 GO:1903384 IGI involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway 14652021 Process
11315 GO:1903751 IDA involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide 24947010 Process
11315 GO:1905259 IDA involved_in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway 14752510 Process
11315 GO:2000157 IDA involved_in negative regulation of ubiquitin-specific protease activity 21097510 Process
11315 GO:2000379 IDA involved_in positive regulation of reactive oxygen species metabolic process 20969476 Process
11315 GO:2000679 IMP involved_in positive regulation of transcription regulatory region DNA binding 22492997 Process
11315 GO:2000825 IMP involved_in positive regulation of androgen receptor activity 17510388 Process
11315 GO:2001237 IMP involved_in negative regulation of extrinsic apoptotic signaling pathway 21785459 Process
11315 GO:2001268 IMP involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 21785459 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
11315 GO:0003690 IDA NOT enables double-stranded DNA binding 22683601 Function
11315 GO:0003697 IDA NOT enables single-stranded DNA binding 22683601 Function
11315 GO:0003713 IGI enables transcription coactivator activity 15790595 Function
11315 GO:0003729 IDA enables mRNA binding 18626009 Function
11315 GO:0005102 IPI enables signaling receptor binding 21785459 Function
11315 GO:0005507 IDA enables copper ion binding 23792957 Function
11315 GO:0005515 IPI enables protein binding 11477070,15790595,15983381,16632486,17510388,18000879,19229105..... Function
11315 GO:0008233 IDA enables peptidase activity 20304780 Function
11315 GO:0016532 IDA enables superoxide dismutase copper chaperone activity 24567322 Function
11315 GO:0016684 IDA enables oxidoreductase activity, acting on peroxide as acceptor 24567322 Function
11315 GO:0019899 IPI enables enzyme binding 19703902,19822128,23743200 Function
11315 GO:0019900 IPI enables kinase binding 19229105 Function
11315 GO:0019955 IPI enables cytokine binding 21097510 Function
11315 GO:0036470 IDA enables tyrosine 3-monooxygenase activator activity 19703902 Function
11315 GO:0036478 IDA enables L-dopa decarboxylase activator activity 19703902 Function
11315 GO:0036524 IDA NOT enables protein deglycase activity 31653696 Function
11315 GO:0036524 IDA enables protein deglycase activity 25416785 Function
11315 GO:0042802 IPI enables identical protein binding 15502874,15983381,24947010 Function
11315 GO:0042803 IDA enables protein homodimerization activity 18711745 Function
11315 GO:0042803 IPI enables protein homodimerization activity 24144264,24567322 Function
11315 GO:0044388 IPI enables small protein activating enzyme binding 15983381 Function
11315 GO:0044390 IPI enables ubiquitin-like protein conjugating enzyme binding 15983381 Function
11315 GO:0044877 IDA enables protein-containing complex binding 19822128 Function
11315 GO:0045296 HDA enables cadherin binding 25468996 Function
11315 GO:0045340 IDA enables mercury ion binding 23792957 Function
11315 GO:0050681 IPI enables nuclear androgen receptor binding 17510388 Function
11315 GO:0097110 IPI enables scaffold protein binding 21785459 Function
11315 GO:0140297 IPI enables DNA-binding transcription factor binding 15790595,16731528 Function
11315 GO:1903135 IDA enables cupric ion binding 24567322 Function
11315 GO:1903136 IDA enables cuprous ion binding 24144264,24567322 Function
11315 GO:1990381 IPI enables ubiquitin-specific protease binding 21097510 Function
11315 GO:1990422 IDA enables glyoxalase (glycolic acid-forming) activity 31653696 Function