Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 11816
  • Symbol: Apoe
  • Description: apolipoprotein E

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
11816 GO:0002021 IMP acts_upstream_of_or_within response to dietary excess 17720994 Process
11816 GO:0006629 IGI acts_upstream_of_or_within lipid metabolic process 11120757 Process
11816 GO:0006707 IMP acts_upstream_of_or_within cholesterol catabolic process 9826706 Process
11816 GO:0006874 IDA acts_upstream_of_or_within intracellular calcium ion homeostasis 8185566 Process
11816 GO:0006979 IMP acts_upstream_of_or_within response to oxidative stress 8773783 Process
11816 GO:0008104 IMP NOT acts_upstream_of_or_within protein localization 9325076 Process
11816 GO:0008203 IMP acts_upstream_of_or_within cholesterol metabolic process 1423598,8647961 Process
11816 GO:0010467 IGI acts_upstream_of_or_within_negative_effect gene expression 26397958 Process
11816 GO:0010468 IMP acts_upstream_of_or_within regulation of gene expression 17720994 Process
11816 GO:0010629 IMP involved_in negative regulation of gene expression 18377911 Process
11816 GO:0010875 IMP involved_in positive regulation of cholesterol efflux 31902528 Process
11816 GO:0010877 IMP involved_in lipid transport involved in lipid storage 23741427 Process
11816 GO:0010976 IMP involved_in positive regulation of neuron projection development 23845000 Process
11816 GO:0031103 IGI NOT acts_upstream_of_or_within axon regeneration 7798939 Process
11816 GO:0032438 IMP involved_in melanosome organization 26387950 Process
11816 GO:0033344 IDA acts_upstream_of_or_within cholesterol efflux 15269218 Process
11816 GO:0033344 IMP acts_upstream_of_or_within cholesterol efflux 11551841 Process
11816 GO:0034372 IMP involved_in very-low-density lipoprotein particle remodeling 15654758 Process
11816 GO:0034374 IMP involved_in low-density lipoprotein particle remodeling 15654758 Process
11816 GO:0042157 IGI acts_upstream_of_or_within lipoprotein metabolic process 11120757,13130124 Process
11816 GO:0042157 IMP acts_upstream_of_or_within lipoprotein metabolic process 9788969 Process
11816 GO:0042158 IGI acts_upstream_of_or_within lipoprotein biosynthetic process 14595002 Process
11816 GO:0042159 IMP acts_upstream_of_or_within lipoprotein catabolic process 17720994 Process
11816 GO:0042311 IMP acts_upstream_of_or_within vasodilation 9826706 Process
11816 GO:0042632 IGI acts_upstream_of_or_within cholesterol homeostasis 11120757,16230502 Process
11816 GO:0042632 IMP acts_upstream_of_or_within cholesterol homeostasis 1423598,7798939 Process
11816 GO:0042632 IMP involved_in cholesterol homeostasis 23741427 Process
11816 GO:0042981 IMP involved_in regulation of apoptotic process 29336888 Process
11816 GO:0045088 IMP involved_in regulation of innate immune response 29336888 Process
11816 GO:0048662 IGI acts_upstream_of negative regulation of smooth muscle cell proliferation 18382765 Process
11816 GO:0048844 IGI acts_upstream_of_or_within artery morphogenesis 16230502 Process
11816 GO:0050728 IGI involved_in negative regulation of inflammatory response 21784977 Process
11816 GO:0050807 IDA involved_in regulation of synapse organization 27683909 Process
11816 GO:0050807 IMP involved_in regulation of synapse organization 27683909 Process
11816 GO:0051651 IMP acts_upstream_of_or_within maintenance of location in cell 17720994 Process
11816 GO:0055088 IMP acts_upstream_of_or_within lipid homeostasis 17720994 Process
11816 GO:0070328 IMP involved_in triglyceride homeostasis 23676495,23741427 Process
11816 GO:0071830 IMP involved_in triglyceride-rich lipoprotein particle clearance 23676495 Process
11816 GO:0072359 IMP acts_upstream_of_or_within circulatory system development 19816508 Process
11816 GO:0090205 IMP involved_in positive regulation of cholesterol metabolic process 15654758 Process
11816 GO:0090209 IGI acts_upstream_of_or_within negative regulation of triglyceride metabolic process 9240444 Process
11816 GO:0097006 IMP involved_in regulation of plasma lipoprotein particle levels 23741427 Process
11816 GO:1900223 IMP involved_in positive regulation of amyloid-beta clearance 14741101 Process
11816 GO:1905907 IMP involved_in negative regulation of amyloid fibril formation 14741101 Process
11816 GO:1905920 IMP involved_in positive regulation of CoA-transferase activity 15654758 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
11816 GO:0005515 IPI enables protein binding 23055941,29507344 Function
11816 GO:0043395 IDA enables heparan sulfate proteoglycan binding 23676495 Function
11816 GO:0060228 IMP enables phosphatidylcholine-sterol O-acyltransferase activator activity 15654758 Function
11816 GO:0071813 IDA enables lipoprotein particle binding 11553788 Function
11816 GO:0120020 IDA enables cholesterol transfer activity 15269218 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
11816 GO:0005615 IDA located_in extracellular space 7798939,9186920,9300780,15269218,20005821,23640054 Component
11816 GO:0034362 IDA part_of low-density lipoprotein particle 15654758 Component
11816 GO:0098978 IDA is_active_in glutamatergic synapse 27683909 Component
11816 GO:0098978 IMP is_active_in glutamatergic synapse 27683909 Component