Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 11820
  • Symbol: App
  • Description: amyloid beta precursor protein

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
11820 GO:0000086 IMP acts_upstream_of G2/M transition of mitotic cell cycle 15561424 Process
11820 GO:0000278 IMP acts_upstream_of mitotic cell cycle 15561424 Process
11820 GO:0001967 IGI acts_upstream_of_or_within suckling behavior 9461064 Process
11820 GO:0006417 IDA acts_upstream_of_or_within regulation of translation 16314516 Process
11820 GO:0006468 IMP acts_upstream_of_or_within protein phosphorylation 16025111 Process
11820 GO:0006878 IGI acts_upstream_of_or_within intracellular copper ion homeostasis 15447675 Process
11820 GO:0006878 IMP acts_upstream_of_or_within intracellular copper ion homeostasis 10526140 Process
11820 GO:0006897 IMP acts_upstream_of_or_within endocytosis 16025111 Process
11820 GO:0006979 IGI acts_upstream_of_or_within response to oxidative stress 16478525 Process
11820 GO:0007176 IGI acts_upstream_of_or_within regulation of epidermal growth factor-activated receptor activity 17556541 Process
11820 GO:0007409 IMP acts_upstream_of_or_within axonogenesis 9390996 Process
11820 GO:0007617 IGI acts_upstream_of_or_within mating behavior 9461064 Process
11820 GO:0007626 IGI acts_upstream_of_or_within locomotory behavior 9461064 Process
11820 GO:0008088 IGI acts_upstream_of_or_within axo-dendritic transport 20829454 Process
11820 GO:0008088 IMP NOT acts_upstream_of_or_within axo-dendritic transport 15745965 Process
11820 GO:0008088 IMP acts_upstream_of_or_within axo-dendritic transport 11740561 Process
11820 GO:0008203 IGI acts_upstream_of_or_within cholesterol metabolic process 17920016 Process
11820 GO:0008203 IMP acts_upstream_of_or_within cholesterol metabolic process 17920016 Process
11820 GO:0008344 IMP acts_upstream_of_or_within adult locomotory behavior 7758106,8001115,9754878,10188929 Process
11820 GO:0008542 IMP acts_upstream_of_or_within visual learning 10338291 Process
11820 GO:0010468 IDA acts_upstream_of_or_within regulation of gene expression 12074840 Process
11820 GO:0010971 IMP acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle 15561424 Process
11820 GO:0016199 IMP acts_upstream_of_or_within axon midline choice point recognition 8001115 Process
11820 GO:0016322 IMP acts_upstream_of_or_within neuron remodeling 10219973 Process
11820 GO:0016358 IGI acts_upstream_of_or_within dendrite development 15689559 Process
11820 GO:0016358 IMP acts_upstream_of_or_within dendrite development 9390996,10188929 Process
11820 GO:0030182 IDA acts_upstream_of neuron differentiation 18278038 Process
11820 GO:0030182 IGI acts_upstream_of neuron differentiation 18278038 Process
11820 GO:0030198 IGI acts_upstream_of_or_within extracellular matrix organization 15385965 Process
11820 GO:0030900 IGI acts_upstream_of_or_within forebrain development 15385965 Process
11820 GO:0030900 IMP acts_upstream_of_or_within forebrain development 8001115,10200318 Process
11820 GO:0031175 IDA acts_upstream_of_or_within neuron projection development 8083748 Process
11820 GO:0032760 IGI involved_in positive regulation of tumor necrosis factor production 12808450 Process
11820 GO:0035235 IMP acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway 16025111 Process
11820 GO:0040014 IMP acts_upstream_of_or_within regulation of multicellular organism growth 9754878 Process
11820 GO:0043393 IGI acts_upstream_of_or_within regulation of protein binding 17920016 Process
11820 GO:0043393 IMP acts_upstream_of_or_within regulation of protein binding 17920016 Process
11820 GO:0043408 IDA involved_in regulation of MAPK cascade 15190117 Process
11820 GO:0045665 IDA acts_upstream_of_or_within negative regulation of neuron differentiation 18278038 Process
11820 GO:0045665 IGI acts_upstream_of_or_within negative regulation of neuron differentiation 18278038 Process
11820 GO:0045666 IDA involved_in positive regulation of neuron differentiation 15190117 Process
11820 GO:0045931 IMP acts_upstream_of_or_within positive regulation of mitotic cell cycle 15561424 Process
11820 GO:0045944 IDA acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 15944124 Process
11820 GO:0045944 IGI acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 15944124 Process
11820 GO:0048669 IGI acts_upstream_of_or_within collateral sprouting in absence of injury 15689559 Process
11820 GO:0050803 IMP acts_upstream_of_or_within regulation of synapse structure or activity 10219973 Process
11820 GO:0050885 IGI acts_upstream_of_or_within neuromuscular process controlling balance 9461064 Process
11820 GO:0050890 IDA acts_upstream_of_or_within cognition 25592972 Process
11820 GO:0051124 IGI acts_upstream_of_or_within synaptic assembly at neuromuscular junction 15689559 Process
11820 GO:0051402 IGI acts_upstream_of_or_within neuron apoptotic process 16478525 Process
11820 GO:0051563 IGI acts_upstream_of_or_within smooth endoplasmic reticulum calcium ion homeostasis 12431992 Process
11820 GO:0070050 IGI acts_upstream_of_or_within neuron cellular homeostasis 12431992,15447675 Process
11820 GO:0180011 IDA acts_upstream_of_or_within cytoplasmic polyadenylation 16314516 Process
11820 GO:1900272 IDA involved_in negative regulation of long-term synaptic potentiation 18568035 Process
11820 GO:1903523 IGI involved_in negative regulation of blood circulation 12808450 Process
11820 GO:1904472 IGI involved_in positive regulation of endothelin production 12808450 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
11820 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 15944124 Function
11820 GO:0005515 IPI enables protein binding 10460257,11517249,11877420,12826668,16193067,16227578,16227582..... Function
11820 GO:0030546 IDA enables signaling receptor activator activity 11316806 Function
11820 GO:0050750 IPI enables low-density lipoprotein particle receptor binding 22383525 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
11820 GO:0005737 IDA located_in cytoplasm 10845772 Component
11820 GO:0005769 IDA located_in early endosome 25592972 Component
11820 GO:0005794 IDA located_in Golgi apparatus 16018997 Component
11820 GO:0005798 IDA located_in Golgi-associated vesicle 23931995 Component
11820 GO:0005886 IDA located_in plasma membrane 15009636 Component
11820 GO:0005911 IDA located_in cell-cell junction 23793062 Component
11820 GO:0008021 IDA located_in synaptic vesicle 25438880 Component
11820 GO:0009986 IDA located_in cell surface 16227578 Component
11820 GO:0016020 IDA located_in membrane 9535056,10845772,12927782,15886206 Component
11820 GO:0030134 IDA located_in COPII-coated ER to Golgi transport vesicle 19966784 Component
11820 GO:0030424 IDA located_in axon 11740561,15745965,25631124 Component
11820 GO:0031410 IDA located_in cytoplasmic vesicle 11740561,15745965 Component
11820 GO:0031594 IDA located_in neuromuscular junction 10845772 Component
11820 GO:0035253 IDA located_in ciliary rootlet 16018997 Component
11820 GO:0043005 IDA located_in neuron projection 16301330 Component
11820 GO:0045177 IDA located_in apical part of cell 15561424 Component
11820 GO:0048471 IDA located_in perinuclear region of cytoplasm 8207383 Component
11820 GO:0048786 IDA is_active_in presynaptic active zone 23815291 Component
11820 GO:0048786 IEP is_active_in presynaptic active zone 23815291 Component
11820 GO:0051233 IDA located_in spindle midzone 15561424 Component
11820 GO:0055037 IDA located_in recycling endosome 23931995 Component