Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 120892
  • Symbol: LRRK2
  • Description: leucine rich repeat kinase 2

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
120892 GO:0000149 IPI enables SNARE binding 21307259 Function
120892 GO:0000287 IMP enables magnesium ion binding 28720718 Function
120892 GO:0003779 IPI enables actin binding 21307259 Function
120892 GO:0003924 IDA enables GTPase activity 21048939 Function
120892 GO:0004672 IDA enables protein kinase activity 16269541,16321986,17442267,21850687,25500533 Function
120892 GO:0004674 EXP enables protein serine/threonine kinase activity 26751287 Function
120892 GO:0004674 IDA enables protein serine/threonine kinase activity 17200152,19576176,21048939,21850687,22423108,23949442,27830463..... Function
120892 GO:0004674 IMP enables protein serine/threonine kinase activity 28720718 Function
120892 GO:0004706 IDA enables JUN kinase kinase kinase activity 19302196 Function
120892 GO:0004709 IDA enables MAP kinase kinase kinase activity 19302196 Function
120892 GO:0005096 IDA enables GTPase activator activity 17442267 Function
120892 GO:0005515 IPI enables protein binding 16321986,16352719,17400507,18445495,19176810,19196961,19559761..... Function
120892 GO:0005525 IDA enables GTP binding 16980962,17260967,17442267 Function
120892 GO:0015631 IDA enables tubulin binding 21159966 Function
120892 GO:0016301 IDA enables kinase activity 17114044 Function
120892 GO:0016301 IMP enables kinase activity 23916833 Function
120892 GO:0017075 IPI enables syntaxin-1 binding 21307259 Function
120892 GO:0030159 IDA enables signaling receptor complex adaptor activity 22899650 Function
120892 GO:0030276 IPI enables clathrin binding 21307259 Function
120892 GO:0031267 IPI enables small GTPase binding 21048939 Function
120892 GO:0034211 IDA enables GTP-dependent protein kinase activity 17260967 Function
120892 GO:0034211 IMP enables GTP-dependent protein kinase activity 17200152 Function
120892 GO:0036479 IDA enables peroxidase inhibitor activity 21850687 Function
120892 GO:0042802 IPI enables identical protein binding 16321986,18230735,18397888,19712061,19733152,20515039,21073465..... Function
120892 GO:0042803 IPI enables protein homodimerization activity 16321986 Function
120892 GO:0044325 IPI enables transmembrane transporter binding 21370995,22012985 Function
120892 GO:0051018 IPI enables protein kinase A binding 24464040 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
120892 GO:0000165 IDA involved_in MAPK cascade 17200152 Process
120892 GO:0001934 IDA involved_in positive regulation of protein phosphorylation 22012985 Process
120892 GO:0001934 IMP involved_in positive regulation of protein phosphorylation 20659558 Process
120892 GO:0006468 IDA involved_in protein phosphorylation 25500533 Process
120892 GO:0006468 IMP involved_in protein phosphorylation 23628791,28720718 Process
120892 GO:0006897 IGI involved_in endocytosis 24576675 Process
120892 GO:0006897 IMP involved_in endocytosis 24576675 Process
120892 GO:0006979 IMP involved_in response to oxidative stress 19692353 Process
120892 GO:0007005 IMP involved_in mitochondrion organization 22764206 Process
120892 GO:0007029 IMP involved_in endoplasmic reticulum organization 25201882 Process
120892 GO:0007030 IMP involved_in Golgi organization 24510904 Process
120892 GO:0007040 IMP involved_in lysosome organization 25416817 Process
120892 GO:0007254 IDA involved_in JNK cascade 19302196 Process
120892 GO:0007528 IMP involved_in neuromuscular junction development 21159966 Process
120892 GO:0008340 IMP involved_in determination of adult lifespan 19692353 Process
120892 GO:0009267 IMP involved_in cellular response to starvation 24211199 Process
120892 GO:0010506 IMP involved_in regulation of autophagy 24211199 Process
120892 GO:0010508 IMP involved_in positive regulation of autophagy 22012985 Process
120892 GO:0010955 IDA involved_in negative regulation of protein processing 21370995 Process
120892 GO:0014041 IMP involved_in regulation of neuron maturation 21168496 Process
120892 GO:0016242 IMP involved_in negative regulation of macroautophagy 19640926 Process
120892 GO:0016310 IMP involved_in phosphorylation 23916833 Process
120892 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 19576176 Process
120892 GO:0018107 IDA involved_in peptidyl-threonine phosphorylation 21048939 Process
120892 GO:0018107 IMP involved_in peptidyl-threonine phosphorylation 23949442 Process
120892 GO:0019722 IMP involved_in calcium-mediated signaling 25416817 Process
120892 GO:0021772 IMP involved_in olfactory bulb development 21168496 Process
120892 GO:0022028 IMP involved_in tangential migration from the subventricular zone to the olfactory bulb 21168496 Process
120892 GO:0031398 IDA involved_in positive regulation of protein ubiquitination 16352719,20173330 Process
120892 GO:0031647 IMP involved_in regulation of protein stability 26014385 Process
120892 GO:0032091 IMP involved_in negative regulation of protein binding 23949442 Process
120892 GO:0032092 IDA involved_in positive regulation of protein binding 21370995 Process
120892 GO:0034260 IDA acts_upstream_of_or_within negative regulation of GTPase activity 22423108 Process
120892 GO:0034599 IMP involved_in cellular response to oxidative stress 21362567,21857923,22764206 Process
120892 GO:0034614 IMP involved_in cellular response to reactive oxygen species 24576675 Process
120892 GO:0035640 IMP involved_in exploration behavior 20659558 Process
120892 GO:0035751 IMP involved_in regulation of lysosomal lumen pH 22012985 Process
120892 GO:0040012 IMP involved_in regulation of locomotion 19692353 Process
120892 GO:0042391 IMP involved_in regulation of membrane potential 21159966 Process
120892 GO:0043068 IDA involved_in positive regulation of programmed cell death 17200152 Process
120892 GO:0043406 IMP involved_in positive regulation of MAP kinase activity 21857923 Process
120892 GO:0045860 IDA involved_in positive regulation of protein kinase activity 19302196 Process
120892 GO:0046039 IDA involved_in GTP metabolic process 21048939 Process
120892 GO:0046777 IDA involved_in protein autophosphorylation 16269541,16321986,17200152,17442267 Process
120892 GO:0046777 IMP involved_in protein autophosphorylation 16980962 Process
120892 GO:0048312 IMP involved_in intracellular distribution of mitochondria 21159966 Process
120892 GO:0048812 IMP involved_in neuron projection morphogenesis 17114044 Process
120892 GO:0051646 IMP involved_in mitochondrion localization 22764206 Process
120892 GO:0051900 IMP involved_in regulation of mitochondrial depolarization 22736029 Process
120892 GO:0060161 IMP involved_in positive regulation of dopamine receptor signaling pathway 20659558 Process
120892 GO:0061001 IMP involved_in regulation of dendritic spine morphogenesis 21168496 Process
120892 GO:0070973 IMP involved_in protein localization to endoplasmic reticulum exit site 25201882 Process
120892 GO:0071287 IMP involved_in cellular response to manganese ion 23628791 Process
120892 GO:0090263 IGI involved_in positive regulation of canonical Wnt signaling pathway 22899650 Process
120892 GO:1901214 IMP involved_in regulation of neuron death 24403142 Process
120892 GO:1902236 IMP involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 21857923 Process
120892 GO:1902499 IDA involved_in positive regulation of protein autoubiquitination 16352719 Process
120892 GO:1902692 IMP involved_in regulation of neuroblast proliferation 21168496 Process
120892 GO:1902902 IMP involved_in negative regulation of autophagosome assembly 23916833 Process
120892 GO:1903125 IDA involved_in negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation 21850687 Process
120892 GO:1903215 IDA involved_in negative regulation of protein targeting to mitochondrion 21370995 Process
120892 GO:1903351 IMP involved_in cellular response to dopamine 23628791 Process
120892 GO:1904887 IPI involved_in Wnt signalosome assembly 22899650 Process
120892 GO:1905279 IGI involved_in regulation of retrograde transport, endosome to Golgi 23395371 Process
120892 GO:1905289 IMP involved_in regulation of CAMKK-AMPK signaling cascade 22012985 Process
120892 GO:2000172 IMP involved_in regulation of branching morphogenesis of a nerve 21168496 Process
120892 GO:2000300 IMP involved_in regulation of synaptic vesicle exocytosis 23949442 Process
120892 GO:2000377 IMP involved_in regulation of reactive oxygen species metabolic process 24576675 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
120892 GO:0005615 HDA located_in extracellular space 22664934 Component
120892 GO:0005737 IDA located_in cytoplasm 16321986,16352719,19625296 Component
120892 GO:0005737 IMP located_in cytoplasm 26014385 Component
120892 GO:0005739 IDA located_in mitochondrion 21850687 Component
120892 GO:0005783 IDA located_in endoplasmic reticulum 19640926 Component
120892 GO:0005794 IDA located_in Golgi apparatus 23395371 Component
120892 GO:0005798 IDA located_in Golgi-associated vesicle 24510904 Component
120892 GO:0005829 IDA located_in cytosol 21850687,22736029,22899650,24403142 Component
120892 GO:0005886 IDA located_in plasma membrane 22899650 Component
120892 GO:0005902 IDA located_in microvillus 19640926 Component
120892 GO:0016234 IMP located_in inclusion body 24403142 Component
120892 GO:0030424 IDA located_in axon 17120249 Component
120892 GO:0030425 IDA located_in dendrite 17120249 Component
120892 GO:0030426 IDA located_in growth cone 19625296 Component
120892 GO:0031966 IDA located_in mitochondrial membrane 22736029 Component
120892 GO:0032473 IDA located_in cytoplasmic side of mitochondrial outer membrane 16269541 Component
120892 GO:0032839 IDA located_in dendrite cytoplasm 21696411 Component
120892 GO:0043005 IDA located_in neuron projection 19625296,21048939 Component
120892 GO:0043025 IDA located_in neuronal cell body 21048939,21696411 Component
120892 GO:0043204 IDA located_in perikaryon 17120249 Component
120892 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component
120892 GO:0044753 IDA located_in amphisome 19640926 Component
120892 GO:0044754 IDA located_in autolysosome 19640926 Component
120892 GO:0070062 HDA located_in extracellular exosome 19056867 Component
120892 GO:0070971 IDA located_in endoplasmic reticulum exit site 25201882 Component
120892 GO:0097487 IDA located_in multivesicular body, internal vesicle 19640926 Component
120892 GO:0099400 IDA located_in caveola neck 19640926 Component
120892 GO:1990909 IDA part_of Wnt signalosome 22899650 Component