Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 12286
  • Symbol: Cacna1a
  • Description: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12286 GO:0001505 IMP acts_upstream_of_or_within regulation of neurotransmitter levels 1686215,6167317,8100981 Process
12286 GO:0006816 IMP acts_upstream_of_or_within calcium ion transport 9614225,9857013,12827191 Process
12286 GO:0007204 IDA acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration 8632762 Process
12286 GO:0007214 IMP acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway 8565963 Process
12286 GO:0007268 IMP acts_upstream_of_or_within chemical synaptic transmission 10611370,12040045,15548652 Process
12286 GO:0007270 IMP acts_upstream_of_or_within neuron-neuron synaptic transmission 16540584 Process
12286 GO:0007274 IMP acts_upstream_of_or_within neuromuscular synaptic transmission 10686170 Process
12286 GO:0007416 IMP acts_upstream_of_or_within synapse assembly 10336181,14973254 Process
12286 GO:0007628 IGI acts_upstream_of_or_within adult walking behavior 8719807,9882694 Process
12286 GO:0007628 IMP acts_upstream_of_or_within adult walking behavior 4799944,4941467,8719807,10611370,11160387,11344116,12401561,13..... Process
12286 GO:0010817 IMP acts_upstream_of_or_within regulation of hormone levels 8229069,8957685 Process
12286 GO:0014051 IMP acts_upstream_of_or_within gamma-aminobutyric acid secretion 10670432 Process
12286 GO:0014056 IMP acts_upstream_of_or_within regulation of acetylcholine secretion, neurotransmission 10686170,12624181 Process
12286 GO:0017156 IMP acts_upstream_of_or_within calcium-ion regulated exocytosis 12065603 Process
12286 GO:0017158 IDA acts_upstream_of_or_within regulation of calcium ion-dependent exocytosis 8632762 Process
12286 GO:0019226 IMP acts_upstream_of_or_within transmission of nerve impulse 1355109,1469420,1572065 Process
12286 GO:0021522 IMP acts_upstream_of_or_within spinal cord motor neuron differentiation 17156092 Process
12286 GO:0021590 IMP acts_upstream_of_or_within cerebellum maturation 11344116 Process
12286 GO:0021679 IMP acts_upstream_of_or_within cerebellar molecular layer development 7697385 Process
12286 GO:0021680 IMP acts_upstream_of_or_within cerebellar Purkinje cell layer development 1306163 Process
12286 GO:0021702 IMP acts_upstream_of_or_within cerebellar Purkinje cell differentiation 1306163,7834360,10630211 Process
12286 GO:0021750 IMP acts_upstream_of_or_within vestibular nucleus development 8719615 Process
12286 GO:0021953 IMP acts_upstream_of_or_within central nervous system neuron differentiation 6945603 Process
12286 GO:0030644 IMP acts_upstream_of_or_within intracellular chloride ion homeostasis 8565963,10899223 Process
12286 GO:0031335 IMP acts_upstream_of_or_within regulation of sulfur amino acid metabolic process 1485534 Process
12286 GO:0032353 IMP acts_upstream_of_or_within negative regulation of hormone biosynthetic process 11182254 Process
12286 GO:0035249 IMP acts_upstream_of_or_within synaptic transmission, glutamatergic 10322048,14973254 Process
12286 GO:0042391 IMP acts_upstream_of_or_within regulation of membrane potential 1355109,1572065,9614225,9857013,10670432,12151514,12401561..... Process
12286 GO:0042446 IMP acts_upstream_of hormone biosynthetic process 11182254 Process
12286 GO:0042593 IMP acts_upstream_of_or_within glucose homeostasis 8957685 Process
12286 GO:0043113 IMP acts_upstream_of_or_within receptor clustering 12624181 Process
12286 GO:0043524 IMP acts_upstream_of_or_within negative regulation of neuron apoptotic process 4941467,8929530 Process
12286 GO:0048265 IMP acts_upstream_of_or_within response to pain 11718712 Process
12286 GO:0048266 IMP acts_upstream_of_or_within behavioral response to pain 16890369 Process
12286 GO:0048791 IMP acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter 10670432 Process
12286 GO:0048813 IMP acts_upstream_of_or_within dendrite morphogenesis 10336181,11160387,14973254 Process
12286 GO:0050770 IMP acts_upstream_of_or_within regulation of axonogenesis 572084 Process
12286 GO:0050877 IMP acts_upstream_of_or_within nervous system process 1486501,6462226 Process
12286 GO:0050883 IMP acts_upstream_of_or_within musculoskeletal movement, spinal reflex action 11718712 Process
12286 GO:0050885 IMP acts_upstream_of_or_within neuromuscular process controlling balance 4799944 Process
12286 GO:0050905 IGI acts_upstream_of_or_within neuromuscular process 10630211 Process
12286 GO:0050905 IMP acts_upstream_of_or_within neuromuscular process 11344116 Process
12286 GO:0051402 IMP acts_upstream_of neuron apoptotic process 4941467,8929530 Process
12286 GO:0051649 IMP acts_upstream_of_or_within establishment of localization in cell 9614225,9857013,10670432,12065603 Process
12286 GO:0051899 IMP acts_upstream_of_or_within membrane depolarization 8158221,10908603,11718712 Process
12286 GO:0051932 IMP NOT acts_upstream_of_or_within synaptic transmission, GABAergic 10322048 Process
12286 GO:0060024 IMP acts_upstream_of_or_within rhythmic synaptic transmission 16474392 Process
12286 GO:0070050 IMP acts_upstream_of_or_within neuron cellular homeostasis 10899223 Process
12286 GO:0070588 IDA acts_upstream_of_or_within calcium ion transmembrane transport 25741235 Process
12286 GO:0099509 IDA acts_upstream_of_or_within regulation of presynaptic cytosolic calcium ion concentration 25741235 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12286 GO:0005245 IDA enables voltage-gated calcium channel activity 8632762 Function
12286 GO:0005245 IMP enables voltage-gated calcium channel activity 9614225,9857013,10611370,12151514,12827191 Function
12286 GO:0005515 IPI enables protein binding 1370480,10328888 Function
12286 GO:0008331 IGI enables high voltage-gated calcium channel activity 11756409 Function
12286 GO:0008331 IMP enables high voltage-gated calcium channel activity 9742139,10908603,11344116,11718712,12040045,12065603,12401561,..... Function
12286 GO:0099626 IDA enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels 25741235 Function
12286 GO:0099626 IMP enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels 25741235 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12286 GO:0005891 IDA part_of voltage-gated calcium channel complex 10328888 Component
12286 GO:0030425 IDA located_in dendrite 15451373 Component
12286 GO:0043025 IDA located_in neuronal cell body 15451373 Component
12286 GO:0098978 IDA is_active_in glutamatergic synapse 25741235 Component
12286 GO:0098978 IMP is_active_in glutamatergic synapse 25741235 Component