Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 12575
  • Symbol: Cdkn1a
  • Description: cyclin dependent kinase inhibitor 1A

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12575 GO:0000079 IMP acts_upstream_of_or_within regulation of cyclin-dependent protein serine/threonine kinase activity 11981756 Process
12575 GO:0006606 IMP acts_upstream_of_or_within protein import into nucleus 11981756 Process
12575 GO:0006974 IMP acts_upstream_of_or_within DNA damage response 12952892 Process
12575 GO:0006978 IDA acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 10710310 Process
12575 GO:0007346 IDA acts_upstream_of_or_within regulation of mitotic cell cycle 15831459,17515607 Process
12575 GO:0007346 IMP acts_upstream_of_or_within regulation of mitotic cell cycle 11981756 Process
12575 GO:0007507 IMP involved_in heart development 24380855 Process
12575 GO:0008285 IMP acts_upstream_of_or_within negative regulation of cell population proliferation 12759355,14712235 Process
12575 GO:0008544 IGI acts_upstream_of_or_within epidermis development 11551927 Process
12575 GO:0009411 IMP acts_upstream_of_or_within response to UV 12952892 Process
12575 GO:0010629 IMP acts_upstream_of_or_within negative regulation of gene expression 11981756 Process
12575 GO:0030216 IGI acts_upstream_of_or_within keratinocyte differentiation 11551927 Process
12575 GO:0030890 IGI acts_upstream_of_or_within positive regulation of B cell proliferation 12970760 Process
12575 GO:0034198 IMP involved_in cellular response to amino acid starvation 26102367 Process
12575 GO:0042060 IMP involved_in wound healing 20231440 Process
12575 GO:0042246 IMP involved_in tissue regeneration 20231440 Process
12575 GO:0042771 IMP acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 12952892 Process
12575 GO:0043068 IMP acts_upstream_of_or_within positive regulation of programmed cell death 12759355 Process
12575 GO:0043616 IGI acts_upstream_of_or_within keratinocyte proliferation 11551927 Process
12575 GO:0045736 IDA acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity 12130539 Process
12575 GO:0051726 IDA acts_upstream_of_or_within regulation of cell cycle 12588994 Process
12575 GO:0051726 IMP involved_in regulation of cell cycle 24380855,26102367 Process
12575 GO:0071480 IDA acts_upstream_of_or_within cellular response to gamma radiation 10710310 Process
12575 GO:0071493 IDA involved_in cellular response to UV-B 25329316 Process
12575 GO:0090398 IGI acts_upstream_of_or_within cellular senescence 11551927 Process
12575 GO:0090402 IGI acts_upstream_of_or_within oncogene-induced cell senescence 11551927 Process
12575 GO:0090402 IMP acts_upstream_of_or_within oncogene-induced cell senescence 11551927 Process
12575 GO:1905179 IMP involved_in negative regulation of cardiac muscle tissue regeneration 24380855 Process
12575 GO:2000278 IMP acts_upstream_of_or_within regulation of DNA biosynthetic process 11981756 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12575 GO:0000307 IPI part_of cyclin-dependent protein kinase holoenzyme complex 12970760 Component
12575 GO:0005634 IDA located_in nucleus 11254359,12970760 Component
12575 GO:0005737 IDA located_in cytoplasm 11254359 Component
12575 GO:0005829 IDA located_in cytosol 15964824 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12575 GO:0004861 IDA enables cyclin-dependent protein serine/threonine kinase inhibitor activity 12130539 Function
12575 GO:0005515 IPI enables protein binding 11022036,12124778,12588994,12970760,19416922,24380855,25329316..... Function
12575 GO:0030332 IDA enables cyclin binding 12124778,24380855 Function