Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 12638
  • Symbol: Cftr
  • Description: cystic fibrosis transmembrane conductance regulator

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12638 GO:0003254 IMP NOT involved_in regulation of membrane depolarization 24885604 Process
12638 GO:0006695 IMP acts_upstream_of_or_within cholesterol biosynthetic process 17085523 Process
12638 GO:0006821 IGI acts_upstream_of_or_within chloride transport 19033647 Process
12638 GO:0006904 IMP involved_in vesicle docking involved in exocytosis 24885604 Process
12638 GO:0030301 IMP acts_upstream_of_or_within cholesterol transport 17085523 Process
12638 GO:0035774 IMP involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus 24885604 Process
12638 GO:0045921 IMP involved_in positive regulation of exocytosis 24885604 Process
12638 GO:0048240 IMP involved_in sperm capacitation 21976599 Process
12638 GO:0051454 IMP involved_in intracellular pH elevation 21976599 Process
12638 GO:0051649 IGI acts_upstream_of_or_within establishment of localization in cell 19033647 Process
12638 GO:0060081 IMP involved_in membrane hyperpolarization 21976599 Process
12638 GO:0070175 IDA involved_in positive regulation of enamel mineralization 26403673 Process
12638 GO:0071320 IDA involved_in cellular response to cAMP 21976599 Process
12638 GO:0097186 IDA involved_in amelogenesis 26403673 Process
12638 GO:1902161 IMP involved_in positive regulation of cyclic nucleotide-gated ion channel activity 24885604 Process
12638 GO:1902476 IDA involved_in chloride transmembrane transport 20231442,26403673 Process
12638 GO:1902476 IMP involved_in chloride transmembrane transport 24885604 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12638 GO:0005254 IDA enables chloride channel activity 20231442 Function
12638 GO:0005254 IMP enables chloride channel activity 24885604 Function
12638 GO:0005515 IPI enables protein binding 19033647,19878303,21976599,23542070 Function
12638 GO:0015106 IMP enables bicarbonate transmembrane transporter activity 21976599 Function
12638 GO:0015108 IMP enables chloride transmembrane transporter activity 21976599 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
12638 GO:0005829 IDA located_in cytosol 24885604 Component
12638 GO:0005886 IDA located_in plasma membrane 24885604 Component
12638 GO:0016324 IDA located_in apical plasma membrane 16537650,21884936 Component