Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 14265
  • Symbol: Fmr1
  • Description: fragile X messenger ribonucleoprotein 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
14265 GO:0000381 IDA involved_in regulation of alternative mRNA splicing, via spliceosome 18653529 Process
14265 GO:0006281 IDA involved_in DNA repair 24813610 Process
14265 GO:0006406 IDA involved_in mRNA export from nucleus 31340148 Process
14265 GO:0007215 IDA involved_in glutamate receptor signaling pathway 18539120 Process
14265 GO:0007215 IMP involved_in glutamate receptor signaling pathway 11438589,17417632 Process
14265 GO:0007417 IMP acts_upstream_of_or_within central nervous system development 12700164 Process
14265 GO:0008089 IMP involved_in anterograde axonal transport 26586091 Process
14265 GO:0010629 IMP involved_in negative regulation of gene expression 23235829 Process
14265 GO:0017148 IDA involved_in negative regulation of translation 14613971 Process
14265 GO:0017148 IMP involved_in negative regulation of translation 27666021 Process
14265 GO:0019226 IMP involved_in transmission of nerve impulse 29901787 Process
14265 GO:0035176 IMP involved_in social behavior 31853066 Process
14265 GO:0043488 IMP involved_in regulation of mRNA stability 17417632 Process
14265 GO:0045727 IMP involved_in positive regulation of translation 19166269 Process
14265 GO:0045947 IDA involved_in negative regulation of translational initiation 18805096 Process
14265 GO:0051028 IDA involved_in mRNA transport 18539120 Process
14265 GO:0051489 IMP involved_in regulation of filopodium assembly 16631377 Process
14265 GO:0051491 IDA involved_in positive regulation of filopodium assembly 18539120 Process
14265 GO:0060996 IGI acts_upstream_of_or_within dendritic spine development 23509247 Process
14265 GO:0060998 IMP involved_in regulation of dendritic spine development 16631377 Process
14265 GO:0060999 IDA involved_in positive regulation of dendritic spine development 18539120 Process
14265 GO:0097396 IMP involved_in response to interleukin-17 31853066 Process
14265 GO:0098976 IMP involved_in excitatory chemical synaptic transmission 30679017 Process
14265 GO:0098977 IMP involved_in inhibitory chemical synaptic transmission 30679017 Process
14265 GO:0099578 IDA involved_in regulation of translation at postsynapse, modulating synaptic transmission 12032354 Process
14265 GO:0099578 IMP involved_in regulation of translation at postsynapse, modulating synaptic transmission 12032354,18614030 Process
14265 GO:1900453 IMP involved_in negative regulation of long-term synaptic depression 11438589 Process
14265 GO:1901800 IDA involved_in positive regulation of proteasomal protein catabolic process 24709664 Process
14265 GO:1905244 IMP involved_in regulation of modification of synaptic structure 16055059 Process
14265 GO:2000637 IDA involved_in positive regulation of miRNA-mediated gene silencing 20159450 Process
14265 GO:2000766 IDA involved_in negative regulation of cytoplasmic translation 11376146 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
14265 GO:0003682 IDA enables chromatin binding 24813610 Function
14265 GO:0003723 IDA enables RNA binding 24349419 Function
14265 GO:0003729 IDA enables mRNA binding 14613971 Function
14265 GO:0003730 IDA enables mRNA 3'-UTR binding 11376146,14613971 Function
14265 GO:0005515 IPI enables protein binding 10567518,11162447,11438699,15381419,16790844,17881655,18539120..... Function
14265 GO:0008017 IDA enables microtubule binding 17881655,18539120 Function
14265 GO:0030371 IDA enables translation repressor activity 11376146 Function
14265 GO:0035198 IDA enables miRNA binding 20159450 Function
14265 GO:0070840 IDA enables dynein complex binding 18539120 Function
14265 GO:1990247 IDA enables N6-methyladenosine-containing RNA binding 31340148 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
14265 GO:0005634 IDA is_active_in nucleus 12700164 Component
14265 GO:0005634 IDA located_in nucleus 12700164 Component
14265 GO:0005694 IDA located_in chromosome 24813610 Component
14265 GO:0005737 IDA located_in cytoplasm 16790844,24709664 Component
14265 GO:0005844 IDA part_of polysome 14613971,15805463 Component
14265 GO:0005845 IDA part_of mRNA cap binding complex 18805096 Component
14265 GO:0010369 IDA located_in chromocenter 24813610 Component
14265 GO:0010494 IDA located_in cytoplasmic stress granule 21933836 Component
14265 GO:0030424 IDA located_in axon 16631377,19193898 Component
14265 GO:0030425 IDA located_in dendrite 16631377,18539120,19193898,22022532 Component
14265 GO:0032433 IDA located_in filopodium tip 16631377 Component
14265 GO:0032797 IDA part_of SMN complex 18093976 Component
14265 GO:0036464 IDA located_in cytoplasmic ribonucleoprotein granule 18539120 Component
14265 GO:0043197 IDA located_in dendritic spine 16631377,18539120 Component
14265 GO:0043204 IDA located_in perikaryon 14613971,19193898 Component
14265 GO:0045202 IDA located_in synapse 12032354,16631377 Component
14265 GO:0048471 IDA located_in perinuclear region of cytoplasm 16790844 Component
14265 GO:0071598 IDA located_in neuronal ribonucleoprotein granule 18539120,21933836 Component
14265 GO:0098685 IDA is_active_in Schaffer collateral - CA1 synapse 12032354 Component
14265 GO:0098685 IMP is_active_in Schaffer collateral - CA1 synapse 12032354 Component
14265 GO:0098686 IDA is_active_in hippocampal mossy fiber to CA3 synapse 19193898 Component
14265 GO:0098793 IDA located_in presynapse 19193898 Component
14265 GO:0098794 IDA located_in postsynapse 12032354,17254795,19193898 Component
14265 GO:0098978 IDA is_active_in glutamatergic synapse 19193898 Component
14265 GO:0099523 IDA is_active_in presynaptic cytosol 19193898 Component
14265 GO:1902737 IDA located_in dendritic filopodium 16631377,18539120 Component
14265 GO:1990812 IDA located_in growth cone filopodium 16631377 Component