Gene Ontology

Gene Info

• Species: Mouse (Mus musculus)
• GeneID: 14466
• Symbol: Gba
• Description: glucosidase, beta, acid

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
14466	GO:0000423	IMP	acts_upstream_of_or_within	mitophagy	23707074	Process
14466	GO:0006678	IMP	acts_upstream_of_or_within	glucosylceramide metabolic process	17954912,18346921	Process
14466	GO:0006680	IDA	involved_in	glucosylceramide catabolic process	24211208	Process
14466	GO:0006680	IMP	involved_in	glucosylceramide catabolic process	21700325,23707074	Process
14466	GO:0006914	IMP	acts_upstream_of_or_within	autophagy	23707074	Process
14466	GO:0006914	IMP	involved_in	autophagy	27378698	Process
14466	GO:0007005	IMP	acts_upstream_of_or_within	mitochondrion organization	23707074	Process
14466	GO:0007040	IMP	involved_in	lysosome organization	27378698	Process
14466	GO:0007417	IMP	acts_upstream_of_or_within	central nervous system development	18346921	Process
14466	GO:0008203	IDA	involved_in	cholesterol metabolic process	24211208	Process
14466	GO:0008340	IMP	acts_upstream_of_or_within	determination of adult lifespan	18346921	Process
14466	GO:0009267	IMP	involved_in	cellular response to starvation	23707074	Process
14466	GO:0014004	IMP	acts_upstream_of_or_within	microglia differentiation	17954912	Process
14466	GO:0019882	IMP	acts_upstream_of_or_within	antigen processing and presentation	22665763	Process
14466	GO:0019915	IMP	acts_upstream_of_or_within	lipid storage	17954912	Process
14466	GO:0021694	IMP	acts_upstream_of_or_within	cerebellar Purkinje cell layer formation	17954912	Process
14466	GO:0021859	IMP	acts_upstream_of_or_within	pyramidal neuron differentiation	17954912	Process
14466	GO:0022904	IMP	acts_upstream_of_or_within	respiratory electron transport chain	23707074	Process
14466	GO:0030259	IDA	involved_in	lipid glycosylation	24211208	Process
14466	GO:0031333	IMP	involved_in	negative regulation of protein-containing complex assembly	23707074	Process
14466	GO:0032006	IMP	involved_in	regulation of TOR signaling	27378698	Process
14466	GO:0032436	IMP	involved_in	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	23707074	Process
14466	GO:0033077	IMP	acts_upstream_of_or_within	T cell differentiation in thymus	22665763	Process
14466	GO:0035745	IMP	acts_upstream_of_or_within	T-helper 2 cell cytokine production	22665763	Process
14466	GO:0042391	IMP	acts_upstream_of_or_within	regulation of membrane potential	23707074	Process
14466	GO:0043161	IMP	acts_upstream_of_or_within	proteasome-mediated ubiquitin-dependent protein catabolic process	23707074	Process
14466	GO:0043524	IMP	acts_upstream_of_or_within	negative regulation of neuron apoptotic process	17954912	Process
14466	GO:0048469	IMP	acts_upstream_of_or_within	cell maturation	22665763	Process
14466	GO:0048854	IMP	acts_upstream_of_or_within	brain morphogenesis	17954912	Process
14466	GO:0048872	IMP	acts_upstream_of_or_within	homeostasis of number of cells	17954912	Process
14466	GO:0050877	IMP	acts_upstream_of_or_within	nervous system process	17954912,18346921	Process
14466	GO:0050905	IMP	acts_upstream_of_or_within	neuromuscular process	18346921	Process
14466	GO:0051246	IMP	involved_in	regulation of protein metabolic process	23707074	Process
14466	GO:0051248	IMP	involved_in	negative regulation of protein metabolic process	24388731	Process
14466	GO:0051402	IMP	acts_upstream_of_or_within	neuron apoptotic process	17954912,18346921	Process
14466	GO:0061518	IMP	acts_upstream_of_or_within	microglial cell proliferation	17954912	Process
14466	GO:0061744	IMP	acts_upstream_of_or_within	motor behavior	17954912	Process
14466	GO:0071425	IMP	acts_upstream_of_or_within_positive_effect	hematopoietic stem cell proliferation	22665763	Process
14466	GO:0072676	IMP	acts_upstream_of_or_within	lymphocyte migration	22665763	Process
14466	GO:1903052	IMP	involved_in	positive regulation of proteolysis involved in protein catabolic process	21700325	Process
14466	GO:1904925	IMP	involved_in	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	23707074	Process
14466	GO:1905037	IMP	involved_in	autophagosome organization	23707074	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
14466	GO:0004348	IDA	enables	glucosylceramidase activity	22659419,24211208	Function
14466	GO:0004348	IMP	enables	glucosylceramidase activity	21700325,22659419,23707074	Function
14466	GO:0005102	IPI	enables	signaling receptor binding	18022370	Function
14466	GO:0005515	IPI	enables	protein binding	27789271	Function
14466	GO:0008422	IDA	enables	beta-glucosidase activity	22659419	Function
14466	GO:0008422	IMP	enables	beta-glucosidase activity	22659419	Function
14466	GO:0016787	IDA	enables	hydrolase activity	19710420	Function
14466	GO:0046527	IDA	enables	glucosyltransferase activity	24211208	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
14466	GO:0005615	IDA	located_in	extracellular space	19710420	Component
14466	GO:0005764	IDA	located_in	lysosome	27789271	Component
14466	GO:0005765	IDA	located_in	lysosomal membrane	18022370	Component
14466	GO:0005783	IDA	located_in	endoplasmic reticulum	27789271	Component
14466	GO:0005794	IDA	located_in	Golgi apparatus	27789271	Component
14466	GO:0005802	IDA	located_in	trans-Golgi network	27789271	Component
14466	GO:0043202	IDA	located_in	lysosomal lumen	18022370	Component