Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 1514
  • Symbol: CTSL
  • Description: cathepsin L

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1514 GO:0001968 IPI enables fibronectin binding 22952693 Function
1514 GO:0004197 IDA enables cysteine-type endopeptidase activity 12809493,14511383,22952693 Function
1514 GO:0004197 IMP enables cysteine-type endopeptidase activity 28743268 Function
1514 GO:0005515 IPI enables protein binding 12504904,12809493,17889653,25416956,32512386,33774649..... Function
1514 GO:0005518 IDA enables collagen binding 22952693 Function
1514 GO:0008234 IDA enables cysteine-type peptidase activity 8811434 Function
1514 GO:0042393 IDA enables histone binding 21326229 Function
1514 GO:0043394 IPI enables proteoglycan binding 22952693 Function
1514 GO:0097655 IPI enables serpin family protein binding 21383048 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1514 GO:0002250 IEP involved_in adaptive immune response 15196205 Process
1514 GO:0006508 IDA involved_in proteolysis 8811434,21326229 Process
1514 GO:0016540 IDA involved_in protein autoprocessing 9468501 Process
1514 GO:0019064 IDA involved_in fusion of virus membrane with host plasma membrane 32855215 Process
1514 GO:0019065 IDA involved_in receptor-mediated endocytosis of virus by host cell 16081529,32221306,32855215 Process
1514 GO:0030574 IDA involved_in collagen catabolic process 10716919,22952693 Process
1514 GO:0031638 IDA involved_in zymogen activation 9468501 Process
1514 GO:0039654 IDA involved_in fusion of virus membrane with host endosome membrane 16081529,18562523 Process
1514 GO:0046718 IDA involved_in viral entry into host cell 16339146,18562523,26953343,32855215 Process
1514 GO:0051603 IDA involved_in proteolysis involved in protein catabolic process 22952693 Process
1514 GO:0097067 IEP involved_in cellular response to thyroid hormone stimulus 21217776 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1514 GO:0005615 IDA located_in extracellular space 22952693 Component
1514 GO:0005764 IDA located_in lysosome 1837142,15196205,22365146,28743268 Component
1514 GO:0005771 IDA located_in multivesicular body 22365146 Component
1514 GO:0005794 IDA located_in Golgi apparatus Component
1514 GO:0005886 IDA located_in plasma membrane 22365146 Component
1514 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component
1514 GO:0062023 HDA located_in collagen-containing extracellular matrix 25037231 Component
1514 GO:0070062 HDA located_in extracellular exosome 23533145 Component